Molecule

5-(4-chlorophenyl)-6-ethyl-2-imino-2,3-dihydropyrimidin-4-amine

AlkaPlorer ID: AK061339

Synonym: None

IUPAC Name: 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine

Structure

SMILES: CCC1=NC(=N)NC(N)=C1C1=CC=C(Cl)C=C1

InChI: InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)

InChIKey: WKSAUQYGYAYLPV-UHFFFAOYSA-N

Reference

PubChem CID: 4993

CAS: 37338-39-9

SuperNatural Ⅲ: SN0429868

NPASS: NPC478547

COCONUT: CNP0409671

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Millettia usaramensis	Millettia	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Corymbia torelliana	Corymbia	Myrtaceae	Myrtales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Cleistochlamys kirkii	Cleistochlamys	Annonaceae	Magnoliales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Miliusa cuneata	Miliusa	Annonaceae	Magnoliales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Flindersia pimenteliana	Flindersia	Rutaceae	Sapindales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Acronychia pubescens	Acronychia	Rutaceae	Sapindales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 248.717

TPSA？: 78.55

MolLogP？: 2.35417

Number of H-Donors: 3

Number of H-Acceptors: 3

RingCount: 2

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Acinetobacter baumannii	Acinetobacter baumannii	MIC	10000.0	nM	10.6019/CHEMBL4513141
Babesia gibsoni	Babesia gibsoni	Activity	nan	None	10.1128/aac.00384-08
Babesia gibsoni	Babesia gibsoni	Inhibition	nan	%	10.1128/aac.00384-08
Bos taurus	Dihydrofolate reductase	IC50	0.035	ug.mL-1	10.1016/j.bmc.2017.10.041
Bos taurus	Dihydrofolate reductase	IC50	0.035	ug.mL-1	10.1016/j.bmc.2019.06.038
Bos taurus	Dihydrofolate reductase	IC50	0.035	ug.mL-1	10.1016/j.ejmech.2017.02.012
Bos taurus	Dihydrofolate reductase	IC50	100.7	nM	10.1016/j.bmc.2017.05.054
Bos taurus	Dihydrofolate reductase	IC50	100.7	nM	10.1016/j.bmc.2017.07.057
Candida albicans	Candida albicans	MIC	50.0	ug.mL-1	10.1021/jm00018a021
Candida albicans	Candida albicans	MIC	10000.0	nM	10.6019/CHEMBL4513141
Candida albicans	Dihydrofolate reductase	IC50	5000.0	nM	10.1021/jm00018a021
Canis lupus familiaris	MDCK	CC50	41000.0	nM	10.1016/j.ejmech.2017.04.070
Canis lupus familiaris	MDCK	MCC	4000.0	nM	10.1016/j.ejmech.2017.04.070
Chlorocebus sabaeus	Vero	Activity	100.0	uM	10.1021/acsmedchemlett.8b00389
Chlorocebus sabaeus	Vero	Activity	nan	None	10.1016/j.bmc.2020.115345
Chlorocebus sabaeus	Vero	Activity	nan	None	10.1016/j.ejmech.2017.02.024
Chlorocebus sabaeus	Vero	CC50	122000.0	nM	10.1016/j.ejmech.2015.04.028
Chlorocebus sabaeus	Vero	IC50	6.25	ug.mL-1	10.1016/j.bmcl.2017.05.050
Chlorocebus sabaeus	Vero	IC50	62.5	ug.mL-1	10.1016/j.bmcl.2012.12.069
Chlorocebus sabaeus	Vero	IC50	18200.0	nM	10.1021/ml3000808
Chlorocebus sabaeus	Vero	IC50	32000.0	nM	10.1016/j.bmc.2019.115158
Chlorocebus sabaeus	Vero	IC50	32000.0	nM	10.1021/jm010131q
Chlorocebus sabaeus	Vero	IC50	32000.0	nM	10.1021/jm030165t
Chlorocebus sabaeus	Vero	IC50	nan	None	10.1016/j.bmc.2017.10.041
Chlorocebus sabaeus	Vero	IC50	nan	None	10.1016/j.bmc.2019.06.038
Chlorocebus sabaeus	Vero	IC50	nan	None	10.1016/j.ejmech.2014.10.061
Chlorocebus sabaeus	Vero	IC50	nan	None	10.1016/j.ejmech.2017.03.007
Chlorocebus sabaeus	Vero	MCC	20000.0	nM	10.1016/j.ejmech.2017.04.070
Chlorocebus sabaeus	Vero	MNCC	6.25	ug ml-1	10.1016/j.bmc.2016.09.044
Chlorocebus sabaeus	Vero	Safety ratio	0.3	None	10.1021/jm030165t
Chlorocebus sabaeus	Vero	Safety ratio	0.4	None	10.1021/jm030165t
Chlorocebus sabaeus	Vero	Safety ratio	0.8	None	10.1021/jm030165t
Chlorocebus sabaeus	Vero	Safety ratio	400.0	None	10.1021/jm030165t
Coxsackievirus B4	Coxsackievirus B4	EC50	46000.0	nM	10.1016/j.ejmech.2017.04.070
Coxsackievirus B4	Coxsackievirus B4	EC50	100000.0	nM	10.1016/j.ejmech.2017.04.070
Cricetulus griseus	CHO	IC50	271000.0	nM	10.1016/j.ejmech.2014.01.040
Cryptococcus neoformans	Cryptococcus neoformans	MIC	10000.0	nM	10.6019/CHEMBL4513141
Cryptosporidium parvum	Bifunctional dihydrofolate reductase-thymidylate synthase	IC50	1000000.0	nM	10.1016/j.bmcl.2006.05.047
Enterococcus faecium	Enterococcus faecium	IC50	8.0	nM	10.1021/jm00212a010
Enterococcus faecium	Enterococcus faecium	IC50	10500.0	nM	10.1021/jm00212a010
Enterococcus faecium	Enterococcus faecium	Inhibition	nan	%	10.1021/jm00212a010
Enterococcus faecium	Enterococcus faecium	Ratio IC50	1300.0	None	10.1021/jm00212a010
Escherichia coli	Dihydrofolate reductase	IC50	2000.0	nM	10.1021/jm800244v
Escherichia coli	Dihydrofolate reductase	IC50	6600.0	nM	10.1016/j.bmc.2012.05.068
Escherichia coli	Dihydrofolate reductase	Kd	1.4	nM	10.1021/jm00093a026
Escherichia coli	Dihydrofolate reductase	Kd	1.5	nM	10.1021/jm00093a026
Escherichia coli	Dihydrofolate reductase	Kd	13.0	nM	10.1021/jm00093a026
Escherichia coli	Dihydrofolate reductase	Kd	16.0	nM	10.1021/jm00093a026
Escherichia coli	Dihydrofolate reductase	Ki	1.2	nM	10.1021/jm00093a026
Escherichia coli	Dihydrofolate reductase	Ki	5.2	nM	10.1021/jm00093a026
Escherichia coli	Dihydrofolate reductase	Ki	10.0	nM	10.1021/jm00093a026
Escherichia coli	Dihydrofolate reductase	Ki	20.0	nM	10.1021/jm00093a026
Escherichia coli	Dihydrofolate reductase	Ki	281.84	nM	10.1021/jm00402a025
Escherichia coli	Dihydrofolate reductase	Ratio	0.29	nM	10.1021/jm00093a026
Escherichia coli	Dihydrofolate reductase	Ratio	0.8	nM	10.1021/jm00093a026
Escherichia coli	Dihydrofolate reductase	Ratio	1.2	nM	10.1021/jm00093a026
Escherichia coli	Dihydrofolate reductase	Ratio	1.3	nM	10.1021/jm00093a026
Escherichia coli	Escherichia coli	IC50	76000.0	nM	10.1021/jm00212a010
Escherichia coli	Escherichia coli	Inhibition	nan	%	10.1021/jm00212a010
Escherichia coli	Escherichia coli	Log 1/C	3.56	None	10.1021/jm00150a026
Escherichia coli	Escherichia coli	Log 1/C	4.21	None	10.1021/jm00150a026
Escherichia coli	Escherichia coli	MIC	10000.0	nM	10.6019/CHEMBL4513141
Gallus gallus	Gallus gallus	Activity	nan	None	10.1021/jm00208a010
Homo sapiens	697	IC50	3603.62	nM	10.6019/CHEMBL1201861
Homo sapiens	786-0	GI50	4591.98	nM	None
Homo sapiens	8-MG-BA	IC50	25808.45	nM	10.6019/CHEMBL1201861
Homo sapiens	A101D	IC50	72580.91	nM	10.6019/CHEMBL1201861
Homo sapiens	A253 cell line	IC50	25998.24	nM	10.6019/CHEMBL1201861
Homo sapiens	A388	IC50	53033.72	nM	10.6019/CHEMBL1201861
Homo sapiens	A3-KAW	IC50	9441.55	nM	10.6019/CHEMBL1201861
Homo sapiens	A498	GI50	13335.21	nM	None
Homo sapiens	A498	IC50	1582392.15	nM	10.6019/CHEMBL1201861
Homo sapiens	A4-Fuk	IC50	15754.14	nM	10.6019/CHEMBL1201861
Homo sapiens	A549	GI50	1468.93	nM	None
Homo sapiens	A549	Inhibition	nan	%	10.1016/j.bmc.2020.115345
Homo sapiens	ACHN	GI50	5105.05	nM	None
Homo sapiens	ACN	IC50	2299.91	nM	10.6019/CHEMBL1201861
Homo sapiens	Adenosine A1 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A2a receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Adenosine A3 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Aldehyde dehydrogenase 1A1	Potency	39810.7	nM	None
Homo sapiens	ALL-PO	IC50	1185.44	nM	10.6019/CHEMBL1201861
Homo sapiens	Alpha-1a adrenergic receptor	AC50	4000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-1a adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2a adrenergic receptor	AC50	9800.1	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2a adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2a adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2b adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2c adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	AM-38	IC50	655756.15	nM	10.6019/CHEMBL1201861
Homo sapiens	ARH-77	IC50	19532.99	nM	10.6019/CHEMBL1201861
Homo sapiens	Ataxin-2	Potency	8912.5	nM	None
Homo sapiens	ATN-1	IC50	1784.1	nM	10.6019/CHEMBL1201861
Homo sapiens	BB30-HNC	IC50	25367.81	nM	10.6019/CHEMBL1201861
Homo sapiens	BB49-HNC	IC50	321389.25	nM	10.6019/CHEMBL1201861
Homo sapiens	BB65-RCC	IC50	26900.66	nM	10.6019/CHEMBL1201861
Homo sapiens	BC-3	IC50	19477.66	nM	10.6019/CHEMBL1201861
Homo sapiens	BE-13	IC50	7773.64	nM	10.6019/CHEMBL1201861
Homo sapiens	Becker	IC50	1732013.7	nM	10.6019/CHEMBL1201861
Homo sapiens	Beta-1 adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-2 adrenergic receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-2 adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Beta-hexosaminidase subunit alpha	Activity	1.5	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit alpha	Activity	3.2	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit alpha	Activity	3.7	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit alpha	Activity	3.9	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit alpha	Activity	5.2	%	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit alpha	Activity	5.5	%	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit alpha	Activity	9.5	%	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit alpha	Activity	10.4	%	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit alpha	Activity	15.5	%	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit alpha	Activity	30.0	uM	10.1021/jm5017895
Homo sapiens	Beta-hexosaminidase subunit alpha	Activity	nan	None	10.1021/jm5017895
Homo sapiens	Beta-hexosaminidase subunit alpha	Activity	nan	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit alpha	FC	2.1	None	10.1021/jm5017895
Homo sapiens	Beta-hexosaminidase subunit alpha	IC50	8500.0	nM	10.1021/jm5017895
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	1.6	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	1.9	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	2.2	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	2.7	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	4.0	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	4.7	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	5.8	%	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	6.1	%	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	6.7	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	7.0	%	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	10.8	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	23.1	%	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	41.9	%	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	122.0	mU.nmol/h	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	125.0	mU.nmol/h	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	205.0	mU.nmol/h	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	237.0	mU.nmol/h	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	Activity	nan	None	10.1074/jbc.m609304200
Homo sapiens	Beta-hexosaminidase subunit beta	IC50	4500.0	nM	10.1021/jm5017895
Homo sapiens	Beta-hexosaminidase subunit beta	IC50	9100.0	nM	10.1021/jm5017895
Homo sapiens	Beta-N-acetyl-D-hexosaminidase-A/B	Activity	nan	None	10.1021/jm5017895
Homo sapiens	Beta-N-acetyl-D-hexosaminidase-A/B	IC50	3100.0	nM	10.1021/jm5017895
Homo sapiens	Beta-N-acetyl-D-hexosaminidase-A/B	IC50	8900.0	nM	10.1021/jm5017895
Homo sapiens	Beta-N-acetyl-D-hexosaminidase-A/B	IC50	14000.0	nM	10.1021/jm5017895
Homo sapiens	Beta-N-acetyl-D-hexosaminidase-A/B	IC50	15000.0	nM	10.1021/jm5017895
Homo sapiens	Beta-N-acetyl-D-hexosaminidase-A/B	IC50	17000.0	nM	10.1021/jm5017895
Homo sapiens	Bile acid receptor FXR	Potency	39810.7	nM	None
Homo sapiens	Bile salt export pump	IC50	200100.0	nM	10.1124/dmd.112.047068
Homo sapiens	BJ	EC50	133300.0	nM	None
Homo sapiens	BL-41	IC50	20947.31	nM	10.6019/CHEMBL1201861
Homo sapiens	BL-70	IC50	14639.36	nM	10.6019/CHEMBL1201861
Homo sapiens	Bradykinin B2 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	BT-474	IC50	1045893.69	nM	10.6019/CHEMBL1201861
Homo sapiens	BT-549	GI50	25822.6	nM	None
Homo sapiens	BV-173	IC50	12693.3	nM	10.6019/CHEMBL1201861
Homo sapiens	C2BBe1	IC50	1158706.99	nM	10.6019/CHEMBL1201861
Homo sapiens	C8166	IC50	1028587.73	nM	10.6019/CHEMBL1201861
Homo sapiens	CA46	IC50	322503.83	nM	10.6019/CHEMBL1201861
Homo sapiens	CAKI-1	GI50	71944.9	nM	None
Homo sapiens	CAL-148	IC50	937804.96	nM	10.6019/CHEMBL1201861
Homo sapiens	Calu-3	MCC	100000.0	nM	10.1016/j.ejmech.2017.04.070
Homo sapiens	Calu-6	IC50	113855.49	nM	10.6019/CHEMBL1201861
Homo sapiens	Cannabinoid CB1 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cannabinoid CB1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	CAS-1	IC50	731297.24	nM	10.6019/CHEMBL1201861
Homo sapiens	CCRF-CEM	GI50	3326.6	nM	None
Homo sapiens	CCRF-CEM	IC50	9389.31	nM	10.6019/CHEMBL1201861
Homo sapiens	Cellular tumor antigen p53	Potency	7943.3	nM	None
Homo sapiens	Cellular tumor antigen p53	Potency	12589.3	nM	None
Homo sapiens	Cellular tumor antigen p53	Potency	31622.8	nM	None
Homo sapiens	Cellular tumor antigen p53	Potency	35481.3	nM	None
Homo sapiens	CESS	IC50	5705.01	nM	10.6019/CHEMBL1201861
Homo sapiens	CGTH-W-1	IC50	17455.98	nM	10.6019/CHEMBL1201861
Homo sapiens	Cholecystokinin A receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	CHP-126	IC50	69010.25	nM	10.6019/CHEMBL1201861
Homo sapiens	CMK	IC50	2460.32	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO 205	GI50	18879.91	nM	None
Homo sapiens	COLO-320-HSR	IC50	3999.21	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-668	IC50	32145.87	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-684	IC50	6755.97	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-800	IC50	128655.46	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-824	IC50	2014575.94	nM	10.6019/CHEMBL1201861
Homo sapiens	COLO-829	IC50	7279.98	nM	10.6019/CHEMBL1201861
Homo sapiens	COR-L279	IC50	6373.67	nM	10.6019/CHEMBL1201861
Homo sapiens	COR-L88	IC50	259999.84	nM	10.6019/CHEMBL1201861
Homo sapiens	CP66-MEL	IC50	1228757.78	nM	10.6019/CHEMBL1201861
Homo sapiens	CPC-N	IC50	47223.28	nM	10.6019/CHEMBL1201861
Homo sapiens	CRO-AP2	IC50	18708.91	nM	10.6019/CHEMBL1201861
Homo sapiens	CTB-1	IC50	27659.96	nM	10.6019/CHEMBL1201861
Homo sapiens	CTV-1	IC50	2476.32	nM	10.6019/CHEMBL1201861
Homo sapiens	CW-2	IC50	2674490.03	nM	10.6019/CHEMBL1201861
Homo sapiens	Cyclooxygenase-2	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cytochrome P450 1A2	AC50	10000.0	nM	None
Homo sapiens	Cytochrome P450 2C19	AC50	nan	None	None
Homo sapiens	Cytochrome P450 2C9	AC50	nan	None	None
Homo sapiens	Cytochrome P450 2C9	Ki	51500.0	nM	10.1021/jm030972s
Homo sapiens	Cytochrome P450 2D6	AC50	7943.28	nM	None
Homo sapiens	Cytochrome P450 2D6	Potency	7943.3	nM	None
Homo sapiens	Cytochrome P450 3A4	AC50	nan	None	None
Homo sapiens	Cytochrome P450 3A4	Potency	5011.9	nM	None
Homo sapiens	Cytochrome P450 3A4	Potency	10000.0	nM	None
Homo sapiens	D-247MG	IC50	1315068.45	nM	10.6019/CHEMBL1201861
Homo sapiens	D-263MG	IC50	531388.82	nM	10.6019/CHEMBL1201861
Homo sapiens	D283 Med	IC50	3285092.21	nM	10.6019/CHEMBL1201861
Homo sapiens	D-336MG	IC50	1729115.01	nM	10.6019/CHEMBL1201861
Homo sapiens	D-392MG	IC50	615657.01	nM	10.6019/CHEMBL1201861
Homo sapiens	D-502MG	IC50	480314.93	nM	10.6019/CHEMBL1201861
Homo sapiens	D-542MG	IC50	1497161.11	nM	10.6019/CHEMBL1201861
Homo sapiens	Daudi	IC50	32414.73	nM	10.6019/CHEMBL1201861
Homo sapiens	DB	IC50	34368.55	nM	10.6019/CHEMBL1201861
Homo sapiens	DEL	IC50	3934.56	nM	10.6019/CHEMBL1201861
Homo sapiens	Delta opioid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	DG-75	IC50	14550.06	nM	10.6019/CHEMBL1201861
Homo sapiens	Dihydrofolate reductase	IC50	400.0	nM	10.1021/jm400086g
Homo sapiens	Dihydrofolate reductase	IC50	760.0	nM	10.1021/acs.jmedchem.8b01754
Homo sapiens	Dihydrofolate reductase	IC50	1680.0	nM	10.1021/acs.jmedchem.8b01754
Homo sapiens	Dihydrofolate reductase	IC50	2600.0	nM	10.1021/jm00018a021
Homo sapiens	Dihydrofolate reductase	IC50	4300.0	nM	10.1021/acsmedchemlett.6b00328
Homo sapiens	Dihydrofolate reductase	IC50	6000.0	nM	10.1016/j.bmc.2012.05.068
Homo sapiens	Dihydrofolate reductase	IC50	6000.0	nM	10.1021/jm800244v
Homo sapiens	Dihydrofolate reductase	Inhibition	nan	%	10.1021/jm5017895
Homo sapiens	Dihydrofolate reductase	Ki	8.0	nM	10.1021/jm010131q
Homo sapiens	Dihydrofolate reductase	Ki	11.0	nM	10.1021/jm981130+
Homo sapiens	Dihydrofolate reductase	Ki	28.2	nM	10.1021/acsmedchemlett.8b00389
Homo sapiens	Dihydrofolate reductase	Ki	28.3	nM	10.1016/j.bmc.2019.115158
Homo sapiens	Dihydrofolate reductase	Ki	30.8	nM	10.1128/aac.01526-09
Homo sapiens	Dihydrofolate reductase	Ki	98.0	nM	10.1021/jm981130+
Homo sapiens	Dihydrofolate reductase	Ki	120.0	nM	10.1021/jm981130+
Homo sapiens	Dihydrofolate reductase	Ki	250.0	nM	10.1021/jm981130+
Homo sapiens	Dihydrofolate reductase	Ki	470.0	nM	10.1016/j.ejmech.2017.04.070
Homo sapiens	DJM-1	IC50	997136.83	nM	10.6019/CHEMBL1201861
Homo sapiens	DMS-114	IC50	58592.17	nM	10.6019/CHEMBL1201861
Homo sapiens	DMS-153	IC50	43412.18	nM	10.6019/CHEMBL1201861
Homo sapiens	DMS-79	IC50	176479.2	nM	10.6019/CHEMBL1201861
Homo sapiens	DOHH-2	IC50	816269.03	nM	10.6019/CHEMBL1201861
Homo sapiens	Dopamine D1 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine transporter	AC50	2200.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	DSH1	IC50	4980.34	nM	10.6019/CHEMBL1201861
Homo sapiens	DU-145	GI50	18706.82	nM	None
Homo sapiens	DU-4475	IC50	21590.32	nM	10.6019/CHEMBL1201861
Homo sapiens	EB2	IC50	1590066.31	nM	10.6019/CHEMBL1201861
Homo sapiens	EB-3	IC50	495503.79	nM	10.6019/CHEMBL1201861
Homo sapiens	ECC12	IC50	2561.76	nM	10.6019/CHEMBL1201861
Homo sapiens	ECC4	IC50	37071.67	nM	10.6019/CHEMBL1201861
Homo sapiens	EC-GI-10	IC50	424865.65	nM	10.6019/CHEMBL1201861
Homo sapiens	EKVX	GI50	7550.92	nM	None
Homo sapiens	EKVX	IC50	245218.34	nM	10.6019/CHEMBL1201861
Homo sapiens	EM-2	IC50	12405.41	nM	10.6019/CHEMBL1201861
Homo sapiens	EOL1	IC50	27610.28	nM	10.6019/CHEMBL1201861
Homo sapiens	Equilibrative nucleoside transporter 1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	ES1	IC50	122.9	nM	10.6019/CHEMBL1201861
Homo sapiens	ES3	IC50	175229.4	nM	10.6019/CHEMBL1201861
Homo sapiens	ES4	IC50	3117.18	nM	10.6019/CHEMBL1201861
Homo sapiens	ES5	IC50	2654416.14	nM	10.6019/CHEMBL1201861
Homo sapiens	ES6	IC50	17235.44	nM	10.6019/CHEMBL1201861
Homo sapiens	ES7	IC50	14793.74	nM	10.6019/CHEMBL1201861
Homo sapiens	ES8	IC50	896.67	nM	10.6019/CHEMBL1201861
Homo sapiens	Estrogen receptor alpha	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Estrogen receptor alpha	Potency	7079.5	nM	None
Homo sapiens	ETK-1	IC50	4103.77	nM	10.6019/CHEMBL1201861
Homo sapiens	EVSA-T	IC50	1542943.14	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-1	IC50	1373.08	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-11	IC50	2589295.22	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-12	IC50	1138926.01	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-13	IC50	401789.77	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-16	IC50	15803.4	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-18	IC50	332537.29	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-22	IC50	113374.44	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-24	IC50	54271.22	nM	10.6019/CHEMBL1201861
Homo sapiens	EW-3	IC50	245353.0	nM	10.6019/CHEMBL1201861
Homo sapiens	GAK	IC50	2118015.83	nM	10.6019/CHEMBL1201861
Homo sapiens	Galactocerebrosidase	Potency	707.9	nM	None
Homo sapiens	GB-1	IC50	1047862.86	nM	10.6019/CHEMBL1201861
Homo sapiens	GCIY	IC50	21624.54	nM	10.6019/CHEMBL1201861
Homo sapiens	GDM-1	IC50	42336.22	nM	10.6019/CHEMBL1201861
Homo sapiens	Geminin	Potency	163.6	nM	None
Homo sapiens	Geminin	Potency	2909.3	nM	None
Homo sapiens	Geminin	Potency	5173.5	nM	None
Homo sapiens	Geminin	Potency	6513.1	nM	None
Homo sapiens	Geminin	Potency	13335.9	nM	None
Homo sapiens	Ghrelin receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	GI-1	IC50	585670.88	nM	10.6019/CHEMBL1201861
Homo sapiens	GI-ME-N	IC50	1402.72	nM	10.6019/CHEMBL1201861
Homo sapiens	Glucagon-like peptide 1 receptor	Potency	28183.8	nM	None
Homo sapiens	Glucocorticoid receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Glucose transporter	Inhibition	2.26	%	10.6019/CHEMBL3433997
Homo sapiens	GOTO	IC50	33138.21	nM	10.6019/CHEMBL1201861
Homo sapiens	GR-ST	IC50	708.82	nM	10.6019/CHEMBL1201861
Homo sapiens	GT3TKB	IC50	1939033.63	nM	10.6019/CHEMBL1201861
Homo sapiens	HAL-01	IC50	4741.12	nM	10.6019/CHEMBL1201861
Homo sapiens	HC-1	IC50	5653.96	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC1187	IC50	143337.5	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC1599	IC50	38506.0	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC2157	IC50	97580.43	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC2218	IC50	134968.85	nM	10.6019/CHEMBL1201861
Homo sapiens	HCC 2998	GI50	6251.73	nM	None
Homo sapiens	HCC 2998	IC50	5784.43	nM	10.6019/CHEMBL1201861
Homo sapiens	HCE-T	IC50	1228434.66	nM	10.6019/CHEMBL1201861
Homo sapiens	HCT-116	GI50	6137.62	nM	None
Homo sapiens	HCT-15	GI50	3944.57	nM	None
Homo sapiens	HDLM-2	IC50	443413.17	nM	10.6019/CHEMBL1201861
Homo sapiens	HD-MY-Z	IC50	11915.11	nM	10.6019/CHEMBL1201861
Homo sapiens	HEK293	Activity	62.0	%	10.1021/acs.jnatprod.8b00154
Homo sapiens	HEK293	Activity	75.0	%	10.1021/acs.jnatprod.5b00581
Homo sapiens	HEK293	CC50	10000.0	nM	10.6019/CHEMBL4513141
Homo sapiens	HEK293	CC50	20000.0	nM	10.1021/acs.jmedchem.8b01310
Homo sapiens	HEK293	GI	34.4	%	10.1021/acs.jmedchem.8b01310
Homo sapiens	HEK293	GI	52.0	%	10.1021/acs.jnatprod.8b00956
Homo sapiens	HEK293	GI	53.7	%	10.1021/acs.jmedchem.8b01310
Homo sapiens	HEK293	GI	62.0	%	10.1016/j.bmcl.2017.03.065
Homo sapiens	HEK293	IC50	4.22	nM	10.1021/acs.jnatprod.5b00581
Homo sapiens	HEK293	IC50	8.07	nM	10.1016/j.bmcl.2016.05.039
Homo sapiens	HEK293	IC50	690.0	nM	10.1021/acs.jnatprod.7b00587
Homo sapiens	HEK293	IC50	4200.0	nM	10.1021/acs.jnatprod.6b00759
Homo sapiens	HEK293	IC50	4200.0	nM	10.1021/acs.jnatprod.9b00721
Homo sapiens	HEK293	IC50	10000.0	nM	10.1021/acs.jnatprod.2c01041
Homo sapiens	HEK293	IC50	13921.0	nM	10.6019/CHEMBL2113921
Homo sapiens	HEK293	Potency	3264.3	nM	None
Homo sapiens	HEL	IC50	2670.3	nM	10.6019/CHEMBL1201861
Homo sapiens	HeLa	MCC	100000.0	nM	10.1016/j.ejmech.2017.04.070
Homo sapiens	Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP	IC50	80000.0	nM	None
Homo sapiens	HepG2	CC50	7100.0	nM	10.1016/j.ejmech.2011.06.021
Homo sapiens	HepG2	CC50	7100.0	nM	10.1016/j.ejmech.2012.04.029
Homo sapiens	HepG2	IC50	10000.0	nM	10.1073/pnas.1118370109
Homo sapiens	HepG2	IC50	30000.0	nM	10.1016/j.bmc.2009.05.022
Homo sapiens	HepG2	IC50	nan	None	10.1021/ml3000808
Homo sapiens	HepG2	IC50	nan	None	10.1039/C7MD00052A
Homo sapiens	HepG2	IC50 relative	6000.0	nM	10.6019/EOS300108
Homo sapiens	HepG2	Inhibition	66.0	%	10.1038/nature09107
Homo sapiens	HepG2	Inhibition	71.0	%	10.1038/nature09107
Homo sapiens	HepG2	Potency	1584.9	nM	None
Homo sapiens	HepG2	Potency	2238.7	nM	None
Homo sapiens	HERG	AC50	649.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	HERG	Potency	39810.7	nM	None
Homo sapiens	HFF	CC50	50000.0	nM	10.1016/j.ejmech.2011.06.021
Homo sapiens	HFF	CC50	50000.0	nM	10.1016/j.ejmech.2015.10.004
Homo sapiens	HH	IC50	24454.18	nM	10.6019/CHEMBL1201861
Homo sapiens	Histamine H1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histamine H2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histone deacetylase 1	Inhibition	nan	%	10.1016/j.bmc.2020.115345
Homo sapiens	Histone deacetylase 6	Inhibition	-2.33	%	10.6019/CHEMBL4808148
Homo sapiens	Histone deacetylase 6	Inhibition	3.84	%	10.6019/CHEMBL4808148
Homo sapiens	Histone deacetylase 6	Inhibition	nan	%	10.1016/j.bmc.2020.115345
Homo sapiens	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	IC50	nan	None	10.1039/C7MD00052A
Homo sapiens	HL-60	GI50	2382.32	nM	None
Homo sapiens	HL-60	IC50	301878.62	nM	10.6019/CHEMBL1201861
Homo sapiens	Homo sapiens	DILI_Concern	nan	None	10.1016/j.drudis.2016.02.015
Homo sapiens	Homo sapiens	DILI_severity_class	3.0	None	10.1016/j.drudis.2016.02.015
Homo sapiens	HOP-62	GI50	13396.77	nM	None
Homo sapiens	HOP-62	IC50	5023.22	nM	10.6019/CHEMBL1201861
Homo sapiens	HOP-92	GI50	21281.39	nM	None
Homo sapiens	Hs-578T	GI50	58210.32	nM	None
Homo sapiens	HT	IC50	29381.58	nM	10.6019/CHEMBL1201861
Homo sapiens	HT-144	IC50	6803.16	nM	10.6019/CHEMBL1201861
Homo sapiens	HT-29	GI50	4246.2	nM	None
Homo sapiens	Huh-7	CC50	45620.0	nM	10.1073/pnas.0802982105
Homo sapiens	HuTu80	IC50	12086.23	nM	10.6019/CHEMBL1201861
Homo sapiens	IGROV-1	GI50	9862.79	nM	None
Homo sapiens	IM-9	IC50	2019733.8	nM	10.6019/CHEMBL1201861
Homo sapiens	IMR-5	IC50	967667.95	nM	10.6019/CHEMBL1201861
Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic	Potency	819.9	nM	None
Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic	Potency	3162.3	nM	None
Homo sapiens	IST-MEL1	IC50	4332.89	nM	10.6019/CHEMBL1201861
Homo sapiens	IST-MES1	IC50	611102.07	nM	10.6019/CHEMBL1201861
Homo sapiens	IST-SL1	IC50	16090.52	nM	10.6019/CHEMBL1201861
Homo sapiens	IST-SL2	IC50	11393.72	nM	10.6019/CHEMBL1201861
Homo sapiens	JAR	IC50	77027.92	nM	10.6019/CHEMBL1201861
Homo sapiens	JIYOYE	IC50	10946.02	nM	10.6019/CHEMBL1201861
Homo sapiens	J-RT3-T3-5	IC50	2219.25	nM	10.6019/CHEMBL1201861
Homo sapiens	JVM-2	IC50	980555.26	nM	10.6019/CHEMBL1201861
Homo sapiens	JVM-3	IC50	694117.32	nM	10.6019/CHEMBL1201861
Homo sapiens	K052	IC50	4369828.31	nM	10.6019/CHEMBL1201861
Homo sapiens	K5	IC50	228955.12	nM	10.6019/CHEMBL1201861
Homo sapiens	K562	GI50	542.0	nM	None
Homo sapiens	K562	IC50	5000.0	nM	10.1016/j.bmc.2009.05.022
Homo sapiens	K562	IC50	25674.31	nM	10.6019/CHEMBL1201861
Homo sapiens	KALS-1	IC50	12016.17	nM	10.6019/CHEMBL1201861
Homo sapiens	Kappa opioid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	KARPAS-299	IC50	33193.76	nM	10.6019/CHEMBL1201861
Homo sapiens	KARPAS-422	IC50	18196.82	nM	10.6019/CHEMBL1201861
Homo sapiens	KARPAS-45	IC50	130312.97	nM	10.6019/CHEMBL1201861
Homo sapiens	Kasumi 1	IC50	1573599.58	nM	10.6019/CHEMBL1201861
Homo sapiens	KB	IC50	109000.0	nM	10.1021/jm010131q
Homo sapiens	KB	IC50	109000.0	nM	10.1021/jm030165t
Homo sapiens	KB	Safety ratio	1.1	None	10.1021/jm030165t
Homo sapiens	KB	Safety ratio	2.6	None	10.1021/jm030165t
Homo sapiens	KB	Safety ratio	1362.0	None	10.1021/jm030165t
Homo sapiens	KE-37	IC50	10193.21	nM	10.6019/CHEMBL1201861
Homo sapiens	KG-1	IC50	808640.14	nM	10.6019/CHEMBL1201861
Homo sapiens	KGN	IC50	83867.23	nM	10.6019/CHEMBL1201861
Homo sapiens	KINGS-1	IC50	146388.64	nM	10.6019/CHEMBL1201861
Homo sapiens	KM12	GI50	11641.26	nM	None
Homo sapiens	KM12	IC50	2323.43	nM	10.6019/CHEMBL1201861
Homo sapiens	KM-H2	IC50	11960.88	nM	10.6019/CHEMBL1201861
Homo sapiens	KMOE-2	IC50	137487.22	nM	10.6019/CHEMBL1201861
Homo sapiens	KMS-12-PE	IC50	1299055.84	nM	10.6019/CHEMBL1201861
Homo sapiens	KNS-42	IC50	1210608.01	nM	10.6019/CHEMBL1201861
Homo sapiens	KNS-81-FD	IC50	1974816.97	nM	10.6019/CHEMBL1201861
Homo sapiens	KP-N-YN	IC50	2223293.65	nM	10.6019/CHEMBL1201861
Homo sapiens	KP-N-YS	IC50	221801.31	nM	10.6019/CHEMBL1201861
Homo sapiens	KS-1	IC50	62276.18	nM	10.6019/CHEMBL1201861
Homo sapiens	KU812 cell line	IC50	15644.81	nM	10.6019/CHEMBL1201861
Homo sapiens	KURAMOCHI	IC50	22649.66	nM	10.6019/CHEMBL1201861
Homo sapiens	KY821	IC50	725706.02	nM	10.6019/CHEMBL1201861
Homo sapiens	L-363	IC50	36242.19	nM	10.6019/CHEMBL1201861
Homo sapiens	L-428	IC50	339805.03	nM	10.6019/CHEMBL1201861
Homo sapiens	L-540	IC50	10489.94	nM	10.6019/CHEMBL1201861
Homo sapiens	LAMA-84	IC50	2663.4	nM	10.6019/CHEMBL1201861
Homo sapiens	LAN-6	IC50	349781.96	nM	10.6019/CHEMBL1201861
Homo sapiens	LB1047-RCC	IC50	710409.1	nM	10.6019/CHEMBL1201861
Homo sapiens	LB2241-RCC	IC50	670227.36	nM	10.6019/CHEMBL1201861
Homo sapiens	LB2518-MEL	IC50	175804.4	nM	10.6019/CHEMBL1201861
Homo sapiens	LB373-MEL-D	IC50	2489193.4	nM	10.6019/CHEMBL1201861
Homo sapiens	LB647-SCLC	IC50	66590.37	nM	10.6019/CHEMBL1201861
Homo sapiens	LB771-HNC	IC50	608754.46	nM	10.6019/CHEMBL1201861
Homo sapiens	LB831-BLC	IC50	540248.92	nM	10.6019/CHEMBL1201861
Homo sapiens	LB996-RCC	IC50	791189.89	nM	10.6019/CHEMBL1201861
Homo sapiens	LC-1F	IC50	41775.16	nM	10.6019/CHEMBL1201861
Homo sapiens	LC-2-ad	IC50	45260.79	nM	10.6019/CHEMBL1201861
Homo sapiens	LC4-1	IC50	27223.78	nM	10.6019/CHEMBL1201861
Homo sapiens	LNCaP-Clone-FGC	IC50	309503.07	nM	10.6019/CHEMBL1201861
Homo sapiens	LOUCY	IC50	10940.75	nM	10.6019/CHEMBL1201861
Homo sapiens	Low molecular weight phosphotyrosine protein phosphatase	IC50	16500.0	nM	None
Homo sapiens	Low molecular weight phosphotyrosine protein phosphatase	IC50	32900.0	nM	None
Homo sapiens	LOX IMVI	GI50	6194.41	nM	None
Homo sapiens	LOX IMVI	IC50	13014.21	nM	10.6019/CHEMBL1201861
Homo sapiens	LP-1	IC50	117149.16	nM	10.6019/CHEMBL1201861
Homo sapiens	LS-1034	IC50	18311.46	nM	10.6019/CHEMBL1201861
Homo sapiens	LS-123	IC50	1496950.02	nM	10.6019/CHEMBL1201861
Homo sapiens	LS-411N	IC50	836.81	nM	10.6019/CHEMBL1201861
Homo sapiens	LS-513	IC50	71981.99	nM	10.6019/CHEMBL1201861
Homo sapiens	LU-134-A	IC50	304776.28	nM	10.6019/CHEMBL1201861
Homo sapiens	LU-139	IC50	11125.68	nM	10.6019/CHEMBL1201861
Homo sapiens	LU-165	IC50	368295.65	nM	10.6019/CHEMBL1201861
Homo sapiens	Lu-65	IC50	11046.53	nM	10.6019/CHEMBL1201861
Homo sapiens	LXF-289 cell line	IC50	1224487.91	nM	10.6019/CHEMBL1201861
Homo sapiens	Lymphoblastoid cell	Potency	5011.9	nM	None
Homo sapiens	Lymphoblastoid cell	Potency	7943.3	nM	None
Homo sapiens	Lymphoblastoid cell	Potency	50118.7	nM	None
Homo sapiens	Lymphoblastoid cell	Potency	79432.8	nM	None
Homo sapiens	M14	GI50	5714.79	nM	None
Homo sapiens	Malme-3M	GI50	18197.01	nM	None
Homo sapiens	MC116	IC50	17894.46	nM	10.6019/CHEMBL1201861
Homo sapiens	MC-CAR	IC50	3356946.3	nM	10.6019/CHEMBL1201861
Homo sapiens	MCF7	EC50	11700.0	nM	10.1021/acs.jmedchem.8b01754
Homo sapiens	MCF7	GI50	11142.95	nM	None
Homo sapiens	MCF7	IC50	453000.0	nM	10.1016/j.bmc.2020.115345
Homo sapiens	MDA-MB-134-VI	IC50	1521360.08	nM	10.6019/CHEMBL1201861
Homo sapiens	MDA-MB-231	GI50	9246.98	nM	None
Homo sapiens	MDA-MB-231	IC50	238000.0	nM	10.1016/j.bmc.2020.115345
Homo sapiens	MDA-MB-435	GI50	8356.03	nM	None
Homo sapiens	MDA-N	GI50	4830.59	nM	None
Homo sapiens	MEG-01	IC50	11768.41	nM	10.6019/CHEMBL1201861
Homo sapiens	Melanocortin receptor 3	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Melanocortin receptor 4	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Menin/Histone-lysine N-methyltransferase MLL	Potency	14125.4	nM	None
Homo sapiens	MFH-ino	IC50	673479.12	nM	10.6019/CHEMBL1201861
Homo sapiens	MFM-223	IC50	2148265.39	nM	10.6019/CHEMBL1201861
Homo sapiens	MHH-CALL-2	IC50	93738.41	nM	10.6019/CHEMBL1201861
Homo sapiens	MHH-NB-11	IC50	13709.79	nM	10.6019/CHEMBL1201861
Homo sapiens	MHH-PREB-1	IC50	60394.8	nM	10.6019/CHEMBL1201861
Homo sapiens	ML-2	IC50	11464.16	nM	10.6019/CHEMBL1201861
Homo sapiens	MLMA	IC50	2227889.49	nM	10.6019/CHEMBL1201861
Homo sapiens	MMAC-SF	IC50	2900408.88	nM	10.6019/CHEMBL1201861
Homo sapiens	MN-60	IC50	1029460.34	nM	10.6019/CHEMBL1201861
Homo sapiens	Mo	IC50	4111240.14	nM	10.6019/CHEMBL1201861
Homo sapiens	MOLT-13	IC50	66334.43	nM	10.6019/CHEMBL1201861
Homo sapiens	MOLT-16	IC50	15143.18	nM	10.6019/CHEMBL1201861
Homo sapiens	MOLT-4	GI50	4841.72	nM	None
Homo sapiens	MOLT-4	IC50	5434.63	nM	10.6019/CHEMBL1201861
Homo sapiens	Monoamine oxidase A	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	MONO-MAC-6	IC50	16286.2	nM	10.6019/CHEMBL1201861
Homo sapiens	Mothers against decapentaplegic homolog 3	Potency	35481.3	nM	None
Homo sapiens	Motilin receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	MPP-89	IC50	1204655.6	nM	10.6019/CHEMBL1201861
Homo sapiens	MRC5	ED50	16.2	ug ml-1	10.1021/jm300563f
Homo sapiens	MRC5	ED50	16.23	ug ml-1	10.1021/jm1010572
Homo sapiens	MRK-nu-1	IC50	175567.22	nM	10.6019/CHEMBL1201861
Homo sapiens	MS-1	IC50	2183732.83	nM	10.6019/CHEMBL1201861
Homo sapiens	MSTO-211H	IC50	7643.04	nM	10.6019/CHEMBL1201861
Homo sapiens	Mu opioid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M2	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M3	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	MV4-11	IC50	11397.69	nM	10.6019/CHEMBL1201861
Homo sapiens	MZ1-PC	IC50	26735.84	nM	10.6019/CHEMBL1201861
Homo sapiens	MZ2-MEL	IC50	1077407.53	nM	10.6019/CHEMBL1201861
Homo sapiens	MZ7-mel	IC50	7561.48	nM	10.6019/CHEMBL1201861
Homo sapiens	NALM-6	IC50	19831.57	nM	10.6019/CHEMBL1201861
Homo sapiens	NB1	IC50	22546.37	nM	10.6019/CHEMBL1201861
Homo sapiens	NB10	IC50	1756118.05	nM	10.6019/CHEMBL1201861
Homo sapiens	NB12	IC50	1777985.04	nM	10.6019/CHEMBL1201861
Homo sapiens	NB13	IC50	888698.47	nM	10.6019/CHEMBL1201861
Homo sapiens	NB14	IC50	21167.31	nM	10.6019/CHEMBL1201861
Homo sapiens	NB17	IC50	1191567.56	nM	10.6019/CHEMBL1201861
Homo sapiens	NB5	IC50	1260951.66	nM	10.6019/CHEMBL1201861
Homo sapiens	NB6	IC50	1385610.34	nM	10.6019/CHEMBL1201861
Homo sapiens	NB69	IC50	619642.07	nM	10.6019/CHEMBL1201861
Homo sapiens	NB7	IC50	1641730.26	nM	10.6019/CHEMBL1201861
Homo sapiens	NCCIT	IC50	6934.6	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI/ADR-RES	GI50	30902.95	nM	None
Homo sapiens	NCI-H1092	IC50	699663.15	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1155	IC50	915895.25	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H128	IC50	1840469.53	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1299	IC50	72577.07	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1304	IC50	64946.57	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1355	IC50	322919.48	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1395	IC50	238810.42	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1417	IC50	122494.73	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1436	IC50	2478869.78	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1522	IC50	979876.95	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1581	IC50	168275.75	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1648	IC50	1012135.77	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1650	IC50	120523.89	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1694	IC50	975935.99	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1770	IC50	1715606.6	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1838	IC50	1691024.78	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H187	IC50	234158.91	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1882	IC50	261009.81	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H1963	IC50	21827.44	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2081	IC50	1055504.36	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H209	IC50	6063.38	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2107	IC50	3757841.49	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2126	IC50	47241.13	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2141	IC50	1584108.39	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2171	IC50	312850.36	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2196	IC50	69283.65	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H2227	IC50	646829.02	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H226	GI50	42559.84	nM	None
Homo sapiens	NCI-H226	IC50	2173695.51	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H23	GI50	5794.29	nM	None
Homo sapiens	NCI-H23	IC50	6544.81	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H322M	GI50	100000.0	nM	None
Homo sapiens	NCI-H322M	IC50	1260183.97	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H345	IC50	1083234.77	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H446	IC50	12587858.28	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H460	GI50	2792.54	nM	None
Homo sapiens	NCI-H510A	IC50	156249.02	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H522	GI50	22490.55	nM	None
Homo sapiens	NCI-H524	IC50	34075.68	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H526	IC50	7920.07	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H64	IC50	26284.62	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H69	IC50	215888.05	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H716	IC50	311015.89	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H719	IC50	3531404.69	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H720	IC50	23126.03	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H747	IC50	163211.68	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H748	IC50	242315.6	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H82	IC50	9114.7	nM	10.6019/CHEMBL1201861
Homo sapiens	NCI-H889	IC50	2926050.97	nM	10.6019/CHEMBL1201861
Homo sapiens	NEC8	IC50	1501.68	nM	10.6019/CHEMBL1201861
Homo sapiens	Neuronal acetylcholine receptor protein alpha-4 subunit	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Neuropeptide Y receptor type 1	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	NH-12	IC50	4780426.27	nM	10.6019/CHEMBL1201861
Homo sapiens	NKM-1	IC50	43789.72	nM	10.6019/CHEMBL1201861
Homo sapiens	NMC-G1	IC50	353064.58	nM	10.6019/CHEMBL1201861
Homo sapiens	no-10	IC50	394410.01	nM	10.6019/CHEMBL1201861
Homo sapiens	no-11	IC50	1515609.58	nM	10.6019/CHEMBL1201861
Homo sapiens	NOMO-1	IC50	21503.55	nM	10.6019/CHEMBL1201861
Homo sapiens	Norepinephrine transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	NOS-1	IC50	6659.3	nM	10.6019/CHEMBL1201861
Homo sapiens	NTERA-2-cl-D1	IC50	234565.77	nM	10.6019/CHEMBL1201861
Homo sapiens	Nuclear factor erythroid 2-related factor 2	Potency	11582.1	nM	None
Homo sapiens	Nuclear factor erythroid 2-related factor 2	Potency	37578.0	nM	None
Homo sapiens	Nuclear receptor ROR-gamma	Potency	29849.3	nM	None
Homo sapiens	OCI-AML2	IC50	8500.07	nM	10.6019/CHEMBL1201861
Homo sapiens	OCUB-M	IC50	1246803.06	nM	10.6019/CHEMBL1201861
Homo sapiens	OMC-1	IC50	453201.57	nM	10.6019/CHEMBL1201861
Homo sapiens	ONS-76	IC50	9858.88	nM	10.6019/CHEMBL1201861
Homo sapiens	OPM-2	IC50	22078.96	nM	10.6019/CHEMBL1201861
Homo sapiens	OS-RC-2	IC50	2613.0	nM	10.6019/CHEMBL1201861
Homo sapiens	OVCAR-3	GI50	31988.95	nM	None
Homo sapiens	OVCAR-4	GI50	41591.06	nM	None
Homo sapiens	OVCAR-4	IC50	4153.27	nM	10.6019/CHEMBL1201861
Homo sapiens	OVCAR-5	GI50	59979.11	nM	None
Homo sapiens	OVCAR-8	GI50	5794.29	nM	None
Homo sapiens	P30-OHK	IC50	348498.53	nM	10.6019/CHEMBL1201861
Homo sapiens	P31-FUJ	IC50	4796971.21	nM	10.6019/CHEMBL1201861
Homo sapiens	PC-3	GI50	6501.3	nM	None
Homo sapiens	Peroxisome proliferator-activated receptor delta	Potency	44668.4	nM	None
Homo sapiens	Peroxisome proliferator-activated receptor gamma	Potency	39810.7	nM	None
Homo sapiens	PF-382	IC50	14586.77	nM	10.6019/CHEMBL1201861
Homo sapiens	Phosphodiesterase 3A	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Phosphodiesterase 4D	AC50	12000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Plasma	PPB	87.0	%	10.1021/jm200265b
Homo sapiens	Pregnane X receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Prelamin-A/C	Potency	31622.8	nM	None
Homo sapiens	Progesterone receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	PSN1	IC50	2861.37	nM	10.6019/CHEMBL1201861
Homo sapiens	QIMR-WIL	IC50	6606.0	nM	10.6019/CHEMBL1201861
Homo sapiens	Raji	IC50	105622.24	nM	10.6019/CHEMBL1201861
Homo sapiens	Ramos-2G6-4C10	IC50	5638.54	nM	10.6019/CHEMBL1201861
Homo sapiens	RCC10RGB	IC50	348087.19	nM	10.6019/CHEMBL1201861
Homo sapiens	REH	IC50	9670274.74	nM	10.6019/CHEMBL1201861
Homo sapiens	RH-1	IC50	563516.15	nM	10.6019/CHEMBL1201861
Homo sapiens	RKO	IC50	52085.42	nM	10.6019/CHEMBL1201861
Homo sapiens	RL	IC50	1649025.85	nM	10.6019/CHEMBL1201861
Homo sapiens	RL95-2	IC50	15677.37	nM	10.6019/CHEMBL1201861
Homo sapiens	RPMI-6666	IC50	14555.78	nM	10.6019/CHEMBL1201861
Homo sapiens	RPMI-8226	GI50	34593.94	nM	None
Homo sapiens	RPMI-8226	IC50	97403.49	nM	10.6019/CHEMBL1201861
Homo sapiens	RPMI 8402	IC50	8116.01	nM	10.6019/CHEMBL1201861
Homo sapiens	RPMI-8866	IC50	9696.98	nM	10.6019/CHEMBL1201861
Homo sapiens	RS4-11	IC50	438276.94	nM	10.6019/CHEMBL1201861
Homo sapiens	RXF 393	GI50	76383.58	nM	None
Homo sapiens	RXF 393	IC50	199849.78	nM	10.6019/CHEMBL1201861
Homo sapiens	SBC-1	IC50	95540.57	nM	10.6019/CHEMBL1201861
Homo sapiens	SCC-3	IC50	1841.34	nM	10.6019/CHEMBL1201861
Homo sapiens	SCH	IC50	16869.87	nM	10.6019/CHEMBL1201861
Homo sapiens	SCLC-21H	IC50	185334.81	nM	10.6019/CHEMBL1201861
Homo sapiens	Serotonin 1a (5-HT1a) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 1a (5-HT1a) receptor	AC50	17999.9	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	AC50	4432.2	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2a (5-HT2a) receptor	AC50	11144.5	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2b (5-HT2b) receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2b (5-HT2b) receptor	AC50	11296.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2b (5-HT2b) receptor	AC50	36999.9	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2c (5-HT2c) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2c (5-HT2c) receptor	IC50	nan	None	10.1021/ml300008j
Homo sapiens	Serotonin 3a (5-HT3a) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	SF-126	IC50	158188.13	nM	10.6019/CHEMBL1201861
Homo sapiens	SF-268	GI50	9772.37	nM	None
Homo sapiens	SF-268	IC50	3601.19	nM	10.6019/CHEMBL1201861
Homo sapiens	SF-295	GI50	4436.09	nM	None
Homo sapiens	SF-539	GI50	20701.41	nM	None
Homo sapiens	SF-539	IC50	2546.06	nM	10.6019/CHEMBL1201861
Homo sapiens	SH-4	IC50	203592.82	nM	10.6019/CHEMBL1201861
Homo sapiens	SHP77	IC50	26811.77	nM	10.6019/CHEMBL1201861
Homo sapiens	SIG-M5	IC50	7984.28	nM	10.6019/CHEMBL1201861
Homo sapiens	Signal transducer and activator of transcription 3	Inhibition	nan	%	10.1016/j.bmc.2020.115345
Homo sapiens	Signal transducer and activator of transcription 3	Inhibition	nan	%	10.1021/jm5017895
Homo sapiens	SIMA	IC50	5018081.66	nM	10.6019/CHEMBL1201861
Homo sapiens	SJSA-1	IC50	3774.27	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-LMS-1	IC50	549761.2	nM	10.6019/CHEMBL1201861
Homo sapiens	SKM-1	IC50	179767.08	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-MEL-1	IC50	455403.12	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-MEL-2	GI50	38370.72	nM	None
Homo sapiens	SK-MEL-2	IC50	490005.2	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-MEL-28	GI50	66680.68	nM	None
Homo sapiens	SK-MEL-5	GI50	2477.42	nM	None
Homo sapiens	SK-MM-2	IC50	705713.96	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-N-DZ	IC50	106654.54	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-NEP-1	IC50	1239.89	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-N-FI	IC50	3143546.81	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-OV-3	GI50	74301.91	nM	None
Homo sapiens	SK-PN-DW	IC50	54350.56	nM	10.6019/CHEMBL1201861
Homo sapiens	SK-UT-1	IC50	2622021.86	nM	10.6019/CHEMBL1201861
Homo sapiens	SN12C	GI50	3334.26	nM	None
Homo sapiens	SNB-19	GI50	32809.53	nM	None
Homo sapiens	SNB-75	GI50	44874.54	nM	None
Homo sapiens	SNB-75	IC50	20208.49	nM	10.6019/CHEMBL1201861
Homo sapiens	SNU1	IC50	14738.66	nM	10.6019/CHEMBL1201861
Homo sapiens	SNU-16	IC50	370015.17	nM	10.6019/CHEMBL1201861
Homo sapiens	SNU-5	IC50	727687.72	nM	10.6019/CHEMBL1201861
Homo sapiens	SNU-C1	IC50	666877.25	nM	10.6019/CHEMBL1201861
Homo sapiens	Solute carrier family 22 member 1	IC50	13570.0	nM	10.1021/acs.jmedchem.6b01317
Homo sapiens	Solute carrier family 22 member 1	Ratio	1.26	None	10.1021/acs.jmedchem.6b01317
Homo sapiens	Solute carrier organic anion transporter family member 1B1	Inhibition	72.59	%	10.1124/mol.112.084152
Homo sapiens	Solute carrier organic anion transporter family member 1B3	Inhibition	107.42	%	10.1124/mol.112.084152
Homo sapiens	SR	GI50	4236.43	nM	None
Homo sapiens	SR	IC50	16501.36	nM	10.6019/CHEMBL1201861
Homo sapiens	ST486	IC50	9308.24	nM	10.6019/CHEMBL1201861
Homo sapiens	SU-DHL-1	IC50	10847.22	nM	10.6019/CHEMBL1201861
Homo sapiens	SUP-T1	IC50	2585207.36	nM	10.6019/CHEMBL1201861
Homo sapiens	Survival motor neuron protein	Potency	1778.3	nM	None
Homo sapiens	Survival motor neuron protein	Potency	28183.8	nM	None
Homo sapiens	Survival motor neuron protein	Potency	35481.3	nM	None
Homo sapiens	SW-620	GI50	5610.48	nM	None
Homo sapiens	SW684	IC50	1264708.58	nM	10.6019/CHEMBL1201861
Homo sapiens	SW872	IC50	775667.54	nM	10.6019/CHEMBL1201861
Homo sapiens	SW 954	IC50	283344.93	nM	10.6019/CHEMBL1201861
Homo sapiens	SW 962	IC50	286051.54	nM	10.6019/CHEMBL1201861
Homo sapiens	T47D	GI50	32734.07	nM	None
Homo sapiens	TALL-1	IC50	1895318.16	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-1	IC50	9917.64	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-10	IC50	129733.97	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-12	IC50	42967.93	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-15	IC50	656582.27	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-441-T	IC50	876694.86	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-5	IC50	44910.47	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-6	IC50	41544.04	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-8	IC50	454206.07	nM	10.6019/CHEMBL1201861
Homo sapiens	TE-9	IC50	1085292.7	nM	10.6019/CHEMBL1201861
Homo sapiens	TGBC1TKB	IC50	1703569.44	nM	10.6019/CHEMBL1201861
Homo sapiens	TGW	IC50	34212.87	nM	10.6019/CHEMBL1201861
Homo sapiens	THP-1	GI	94.0	%	10.1016/s0960-894x(00)00112-8
Homo sapiens	THP-1	IC50	1435909.89	nM	10.6019/CHEMBL1201861
Homo sapiens	Thromboxane A2 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	TK-10	GI50	21677.04	nM	None
Homo sapiens	TK-10	IC50	7415.98	nM	10.6019/CHEMBL1201861
Homo sapiens	Trace amine-associated receptor 1	Activity	nan	None	10.1016/j.ejmech.2016.10.058
Homo sapiens	Transthyretin	Activity	-7.1	%	10.1021/acs.jmedchem.1c00823
Homo sapiens	Transthyretin	Activity	-2.6	%	10.1021/acs.jmedchem.1c00823
Homo sapiens	Transthyretin	Activity	53.0	%	10.1021/acs.jmedchem.1c00823
Homo sapiens	Transthyretin	Activity	88.0	%	10.1021/acs.jmedchem.1c00823
Homo sapiens	TUR	IC50	1512269.83	nM	10.6019/CHEMBL1201861
Homo sapiens	Type-1 angiotensin II receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	281.8	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	461.1	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	530.9	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	651.3	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	794.3	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	819.9	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	944.1	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	1299.5	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	3162.3	nM	None
Homo sapiens	Tyrosyl-DNA phosphodiesterase 1	Potency	79432.8	nM	None
Homo sapiens	U-251	GI50	9749.9	nM	None
Homo sapiens	U-266	IC50	5125.68	nM	10.6019/CHEMBL1201861
Homo sapiens	U-698-M	IC50	42688.52	nM	10.6019/CHEMBL1201861
Homo sapiens	U-87 MG	IC50	1192232.64	nM	10.6019/CHEMBL1201861
Homo sapiens	UACC-257	GI50	12473.84	nM	None
Homo sapiens	UACC-257	IC50	3844.51	nM	10.6019/CHEMBL1201861
Homo sapiens	UACC-62	GI50	4720.63	nM	None
Homo sapiens	UACC-812	IC50	695636.32	nM	10.6019/CHEMBL1201861
Homo sapiens	UO-31	GI50	16368.17	nM	None
Homo sapiens	VA-ES-BJ	IC50	15167.27	nM	10.6019/CHEMBL1201861
Homo sapiens	Vasopressin V1a receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Vasopressin V2 receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	WSU-NHL	IC50	107687.98	nM	10.6019/CHEMBL1201861
Homo sapiens	YT	IC50	850300.66	nM	10.6019/CHEMBL1201861
Human respirovirus 3	Human respirovirus 3	EC50	20000.0	nM	10.1016/j.ejmech.2017.04.070
Influenza A virus	Influenza A virus	EC50	15000.0	nM	10.1016/j.ejmech.2017.04.070
Influenza A virus	Influenza A virus	EC50	35000.0	nM	10.1016/j.ejmech.2017.04.070
Influenza B virus	Influenza B virus	EC50	2000.0	nM	10.1016/j.ejmech.2017.04.070
Klebsiella pneumoniae	Klebsiella pneumoniae	MIC	10000.0	nM	10.6019/CHEMBL4513141
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	240.0	nM	10.1021/jm00212a010
Lacticaseibacillus casei	Lacticaseibacillus casei	IC50	5100.0	nM	10.1021/jm00212a010
Lacticaseibacillus casei	Lacticaseibacillus casei	Inhibition	nan	%	10.1021/jm00212a010
Lacticaseibacillus casei	Lacticaseibacillus casei	Ratio IC50	0.05	None	10.1021/jm00212a010
Leishmania donovani	Leishmania donovani	IC50	12060.0	nM	10.6019/CHEMBL3392926
Leishmania donovani	Leishmania donovani	IC50	277830.0	nM	10.6019/CHEMBL3392926
Leishmania major	Leishmania major	Activity	68.0	%	10.1021/jm300563f
Leishmania major	Leishmania major	Inhibition	68.0	%	10.1021/jm1010572
Leishmania major	Pteridine reductase 1	IC50	13600.0	nM	10.1021/acs.jmedchem.8b02021
Leishmania mexicana	Glucose transporter	Inhibition	3.36	%	10.6019/CHEMBL3433997
Leishmania mexicana	Leishmania mexicana	Activity	102.5	%	10.1021/jm300563f
Leishmania mexicana	Leishmania mexicana	IC50	100000.0	nM	10.1016/j.ejmech.2014.12.051
Leishmania mexicana	Leishmania mexicana	Inhibition	50.0	%	10.1016/j.ejmech.2014.12.051
Leishmania mexicana	Leishmania mexicana	Inhibition	102.5	%	10.1021/jm1010572
Macaca mulatta	LLC-MK2	LD50	nan	None	10.1039/C1MD00022E
Mammalian orthoreovirus 1	Mammalian orthoreovirus 1	EC50	5400.0	nM	10.1016/j.ejmech.2017.04.070
Mus musculus	Multidrug and toxin extrusion protein 1	Ki	145.0	nM	10.1016/j.bmc.2013.10.041
Mus musculus	Mus musculus	Activity	nan	None	10.1021/jm00208a010
Mus musculus	Mus musculus	Activity	nan	None	10.1021/jm00227a029
Mus musculus	Mus musculus	Complete survival dose	400.0	mg kg-1	10.1021/jm010089z
Mus musculus	Mus musculus	Delta MST	3.1	day	10.1021/jm00380a018
Mus musculus	Mus musculus	Delta MST	4.7	day	10.1021/jm00366a018
Mus musculus	Mus musculus	Delta MST	4.7	day	10.1021/jm00380a018
Mus musculus	Mus musculus	Delta MST	5.3	day	10.1021/jm00380a018
Mus musculus	Mus musculus	Delta MST	6.1	day	10.1021/jm00366a018
Mus musculus	Mus musculus	Delta MST	6.1	day	10.1021/jm00380a018
Mus musculus	Mus musculus	Delta MST	7.7	day	10.1021/jm00366a018
Mus musculus	Mus musculus	Delta MST	7.7	day	10.1021/jm00380a018
Mus musculus	Mus musculus	Delta MST	nan	None	10.1021/jm00366a018
Mus musculus	Mus musculus	Delta MST	nan	None	10.1021/jm00380a018
Mus musculus	Mus musculus	ED90	1.2	mg kg-1	10.1021/jm010089z
Mus musculus	Mus musculus	MST	nan	None	10.1021/jm00134a002
Mus musculus	Mus musculus	No. of survivals	1.0	None	10.1021/jm00134a002
Mus musculus	Mus musculus	No. of survivals	2.0	None	10.1021/jm00134a002
Mus musculus	Mus musculus	No. of survivals	3.0	None	10.1021/jm00134a002
Mus musculus	Mus musculus	No. of survivals	5.0	None	10.1021/jm00134a002
Mus musculus	Mus musculus	Survival	6.0	%	10.1021/jm010089z
Mus musculus	Plasma	Cp	3.7	uM	10.1016/j.bmc.2013.10.041
Mus musculus	Plasma	Cp(f)	0.3	uM	10.1016/j.bmc.2013.10.041
Mus musculus	Solute carrier family 22 member 1	Ki	3600.0	nM	10.1016/j.bmc.2013.10.041
Mus musculus	Trace amine-associated receptor 1	Activity	nan	None	10.1016/j.ejmech.2016.10.058
Mus musculus	Trace amine-associated receptor 5	EC50	10000.0	nM	10.1016/j.ejmech.2016.10.058
Mycobacterium tuberculosis	Mycobacterium tuberculosis	EC50	24270.0	nM	10.1016/j.bmcl.2012.12.069
Mycobacterium tuberculosis	Mycobacterium tuberculosis	EC50	25090.0	nM	10.1016/j.bmcl.2012.12.069
Mycobacterium tuberculosis	Mycobacterium tuberculosis	EC50	37350.0	nM	10.1016/j.bmcl.2014.01.007
Mycobacterium tuberculosis	Mycobacterium tuberculosis	EC90	28.0	uM	10.1016/j.bmcl.2012.12.069
Mycobacterium tuberculosis	Mycobacterium tuberculosis	EC90	46.37	uM	10.1016/j.bmcl.2012.12.069
Mycobacterium tuberculosis	Mycobacterium tuberculosis	EC90	74.96	uM	10.1016/j.bmcl.2014.01.007
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC50	37.35	ug.mL-1	10.1016/j.ejmech.2013.09.061
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC50	5000.0	nM	10.1016/j.ejmech.2013.12.013
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC50	23300.0	nM	10.1016/j.ejmech.2017.11.035
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC50	23600.0	nM	10.1016/j.bmcl.2016.03.066
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC50	37350.0	nM	10.1016/j.bmc.2016.09.044
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC50	37350.0	nM	10.1016/j.bmcl.2017.05.050
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC50	37350.0	nM	10.1016/j.ejmech.2014.08.009
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC90	74.96	ug.mL-1	10.1016/j.ejmech.2013.09.061
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC90	5000.0	nM	10.1016/j.ejmech.2013.12.013
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC90	35900.0	nM	10.1016/j.ejmech.2017.11.035
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC90	36000.0	nM	10.1016/j.bmcl.2016.03.066
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC90	74960.0	nM	10.1016/j.bmc.2016.09.044
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC90	74960.0	nM	10.1016/j.bmcl.2017.05.050
Mycobacterium tuberculosis	Mycobacterium tuberculosis	IC90	74960.0	nM	10.1016/j.ejmech.2014.08.009
Mycobacterium tuberculosis	Mycobacterium tuberculosis	Inhibition	26.7	%	10.1016/j.ejmech.2013.09.061
Mycobacterium tuberculosis	Mycobacterium tuberculosis	Inhibition	69.7	%	10.1016/j.ejmech.2013.09.061
Mycobacterium tuberculosis	Mycobacterium tuberculosis	Inhibition	95.6	%	10.1016/j.ejmech.2013.09.061
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	50000.0	nM	10.1016/j.bmcl.2016.03.066
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	50000.0	nM	10.1016/j.ejmech.2017.11.035
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	100000.0	nM	10.1016/j.bmc.2016.09.044
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	100000.0	nM	10.1016/j.bmcl.2012.12.069
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	100000.0	nM	10.1016/j.bmcl.2017.05.050
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC	100000.0	nM	10.1016/j.ejmech.2014.08.009
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC90	100000.0	nM	10.1016/j.bmcl.2014.01.007
Mycobacterium tuberculosis	Mycobacterium tuberculosis	MIC90	100000.0	nM	10.1016/j.ejmech.2013.09.061
Mycolicibacterium smegmatis	Mycolicibacterium smegmatis	MIC	101000.0	nM	10.1016/j.bmc.2019.04.032
Plasmodium berghei	Plasmodium berghei	Activity	4.6	%	10.1128/aac.00562-08
Plasmodium berghei	Plasmodium berghei	Activity	91.8	%	10.1128/aac.00562-08
Plasmodium berghei	Plasmodium berghei	Activity	100.0	%	10.1016/j.bmc.2007.05.038
Plasmodium berghei	Plasmodium berghei	Activity	100.0	%	10.1016/j.ejmech.2015.04.028
Plasmodium berghei	Plasmodium berghei	Activity	100.0	%	10.1016/j.ejmech.2018.11.067
Plasmodium berghei	Plasmodium berghei	Activity	nan	None	10.1016/j.bmc.2017.10.017
Plasmodium berghei	Plasmodium berghei	Activity	nan	None	10.1016/j.ejmech.2018.11.067
Plasmodium berghei	Plasmodium berghei	Activity	nan	None	10.1021/jm00208a010
Plasmodium berghei	Plasmodium berghei	Activity	nan	None	10.1128/aac.00562-08
Plasmodium berghei	Plasmodium berghei	Delta MST	1.0	day	10.1021/jm00378a038
Plasmodium berghei	Plasmodium berghei	Delta MST	2.0	day	10.1021/jm00378a038
Plasmodium berghei	Plasmodium berghei	Delta MST	3.0	day	10.1021/jm00378a038
Plasmodium berghei	Plasmodium berghei	Delta MST	3.1	day	10.1021/jm00366a018
Plasmodium berghei	Plasmodium berghei	Delta MST	5.0	day	10.1021/jm00378a038
Plasmodium berghei	Plasmodium berghei	Delta MST	5.3	day	10.1021/jm00366a018
Plasmodium berghei	Plasmodium berghei	Delta MST	7.7	day	10.1021/jm00378a038
Plasmodium berghei	Plasmodium berghei	Delta MST	nan	None	10.1021/jm00366a018
Plasmodium berghei	Plasmodium berghei	IC50	4.7	nM	10.1073/pnas.1118370109
Plasmodium berghei	Plasmodium berghei	Inhibition	50.0	%	10.1021/jm400325j
Plasmodium berghei	Plasmodium berghei	MCD	40.0	mg kg-1	10.1021/jm00212a010
Plasmodium berghei	Plasmodium berghei	MCD	40.0	mg kg-1	10.1021/jm00227a029
Plasmodium berghei	Plasmodium berghei	MED	10.0	mg kg-1	10.1021/jm00212a010
Plasmodium berghei	Plasmodium berghei	MST	3.1	day	10.1021/jm00196a019
Plasmodium berghei	Plasmodium berghei	MST	3.1	day	10.1021/jm00208a010
Plasmodium berghei	Plasmodium berghei	MST	4.7	day	10.1021/jm00196a019
Plasmodium berghei	Plasmodium berghei	MST	4.7	day	10.1021/jm00208a010
Plasmodium berghei	Plasmodium berghei	MST	5.3	day	10.1021/jm00196a019
Plasmodium berghei	Plasmodium berghei	MST	5.3	day	10.1021/jm00208a010
Plasmodium berghei	Plasmodium berghei	MST	6.1	day	10.1021/jm00196a019
Plasmodium berghei	Plasmodium berghei	MST	6.1	day	10.1021/jm00208a010
Plasmodium berghei	Plasmodium berghei	MST	7.7	day	10.1021/jm00134a002
Plasmodium berghei	Plasmodium berghei	MST	7.7	day	10.1021/jm00196a019
Plasmodium berghei	Plasmodium berghei	MST	7.7	day	10.1021/jm00208a010
Plasmodium berghei	Plasmodium berghei	MST	nan	None	10.1021/jm00134a002
Plasmodium berghei	Plasmodium berghei	Ratio	270.0	None	10.1021/jm00208a010
Plasmodium berghei	Plasmodium berghei	SD90	0.28	mg kg-1 day-1	10.1021/jm00134a002
Plasmodium berghei	Plasmodium berghei	SD90	0.28	mg/kg/day	10.1021/jm00208a010
Plasmodium berghei	Plasmodium berghei	Survival	23.0	day	10.1016/j.ejmech.2015.04.028
Plasmodium cynomolgi	Plasmodium cynomolgi	IC50	1030.0	nM	10.1021/jm201095h
Plasmodium falciparum	Cysteine protease falcipain-2	IC50	nan	None	10.1016/j.bmc.2017.10.017
Plasmodium falciparum	Cysteine protease falcipain-2	Inhibition	nan	%	10.1016/j.bmc.2017.10.017
Plasmodium falciparum	Hexose transporter 1	Inhibition	3.31	%	10.6019/CHEMBL3433997
Plasmodium falciparum	Plasmodium falciparum	Activity	0.6	mg kg-1	10.1021/jm00196a019
Plasmodium falciparum	Plasmodium falciparum	Activity	36.0	%	10.1021/acs.jmedchem.0c00451
Plasmodium falciparum	Plasmodium falciparum	Activity	45.0	%	10.1021/acs.jmedchem.0c00451
Plasmodium falciparum	Plasmodium falciparum	Activity	56.3	%	10.1016/j.ejmech.2009.02.008
Plasmodium falciparum	Plasmodium falciparum	Activity	62.0	%	10.1016/j.bmcl.2017.03.065
Plasmodium falciparum	Plasmodium falciparum	Activity	62.0	%	10.1021/acs.jnatprod.8b00154
Plasmodium falciparum	Plasmodium falciparum	Activity	64.0	%	10.1021/acs.jmedchem.0c00451
Plasmodium falciparum	Plasmodium falciparum	Activity	70.0	%	10.1021/acs.jmedchem.0c00451
Plasmodium falciparum	Plasmodium falciparum	Activity	92.2	%	10.1016/j.ejmech.2009.02.008
Plasmodium falciparum	Plasmodium falciparum	Activity	nan	None	10.1016/j.bmcl.2010.11.099
Plasmodium falciparum	Plasmodium falciparum	Activity	nan	None	10.1016/j.ejmech.2017.02.024
Plasmodium falciparum	Plasmodium falciparum	Activity	nan	None	10.1021/acs.jmedchem.0c00451
Plasmodium falciparum	Plasmodium falciparum	Activity	nan	None	10.1021/acsmedchemlett.8b00543
Plasmodium falciparum	Plasmodium falciparum	Activity	nan	None	10.1021/ml3000808
Plasmodium falciparum	Plasmodium falciparum	CD90	0.15	mg kg-1	10.1021/jm00196a019
Plasmodium falciparum	Plasmodium falciparum	EC50	14.56	nM	10.1073/pnas.0802982105
Plasmodium falciparum	Plasmodium falciparum	EC50	18.0	nM	10.1021/acs.jmedchem.0c00451
Plasmodium falciparum	Plasmodium falciparum	EC50	23.0	nM	10.1021/jm200265b
Plasmodium falciparum	Plasmodium falciparum	EC50	31.9	nM	10.1073/pnas.0802982105
Plasmodium falciparum	Plasmodium falciparum	EC50	35.0	nM	10.1021/acsmedchemlett.8b00543
Plasmodium falciparum	Plasmodium falciparum	EC50	100.0	nM	10.1021/acs.jmedchem.9b01099
Plasmodium falciparum	Plasmodium falciparum	EC50	10000.0	nM	10.1021/acs.jmedchem.9b01099
Plasmodium falciparum	Plasmodium falciparum	ED50	2.0	nM	10.1021/jm0491039
Plasmodium falciparum	Plasmodium falciparum	ED50	39.0	nM	10.1021/jm0491039
Plasmodium falciparum	Plasmodium falciparum	ED50	16000.0	nM	10.1021/jm0491039
Plasmodium falciparum	Plasmodium falciparum	ED50	25000.0	nM	10.1021/jm0491039
Plasmodium falciparum	Plasmodium falciparum	ED50	nan	None	10.1021/jm0491039
Plasmodium falciparum	Plasmodium falciparum	ED90	0.5	mg Kg-1	10.1128/aac.00519-09
Plasmodium falciparum	Plasmodium falciparum	ED90	0.9	mg kg-1	10.1021/acs.jmedchem.5b01605
Plasmodium falciparum	Plasmodium falciparum	ED90	0.9	mg Kg-1	10.1128/aac.00519-09
Plasmodium falciparum	Plasmodium falciparum	ED90	50.0	mg Kg-1	10.1128/aac.00519-09
Plasmodium falciparum	Plasmodium falciparum	GI	59.0	%	10.1021/acs.jnatprod.7b00587
Plasmodium falciparum	Plasmodium falciparum	GI	nan	None	10.1016/j.ejmech.2014.10.061
Plasmodium falciparum	Plasmodium falciparum	IC50	0.0001	ug.mL-1	10.1128/aac.01607-06
Plasmodium falciparum	Plasmodium falciparum	IC50	0.0004	ug.mL-1	10.1128/aac.01607-06
Plasmodium falciparum	Plasmodium falciparum	IC50	0.0005	ug.mL-1	10.1128/aac.01607-06
Plasmodium falciparum	Plasmodium falciparum	IC50	0.0012	ug.mL-1	10.1021/jm049683+
Plasmodium falciparum	Plasmodium falciparum	IC50	0.0083	ug.mL-1	10.1128/aac.01607-06
Plasmodium falciparum	Plasmodium falciparum	IC50	0.0119	ug.mL-1	10.1128/aac.01607-06
Plasmodium falciparum	Plasmodium falciparum	IC50	0.028	nM	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	IC50	0.0376	ug.mL-1	10.1128/aac.01607-06
Plasmodium falciparum	Plasmodium falciparum	IC50	0.055	nM	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	IC50	0.13	ug.mL-1	10.1021/jm049683+
Plasmodium falciparum	Plasmodium falciparum	IC50	0.25	ug.mL-1	10.1016/j.bmc.2017.10.041
Plasmodium falciparum	Plasmodium falciparum	IC50	0.25	ug.mL-1	10.1016/j.bmc.2019.06.038
Plasmodium falciparum	Plasmodium falciparum	IC50	0.25	ug.mL-1	10.1016/j.ejmech.2017.02.012
Plasmodium falciparum	Plasmodium falciparum	IC50	1.2	nM	10.1021/jm970845u
Plasmodium falciparum	Plasmodium falciparum	IC50	1.4	nM	10.1039/C1MD00022E
Plasmodium falciparum	Plasmodium falciparum	IC50	2.1	nM	10.1039/C1MD00022E
Plasmodium falciparum	Plasmodium falciparum	IC50	2.3	nM	10.1039/C1MD00022E
Plasmodium falciparum	Plasmodium falciparum	IC50	2.5	nM	10.1021/acs.jnatprod.5b00581
Plasmodium falciparum	Plasmodium falciparum	IC50	2.5	nM	10.1021/acs.jnatprod.6b00759
Plasmodium falciparum	Plasmodium falciparum	IC50	2.5	nM	10.1021/acs.jnatprod.9b00721
Plasmodium falciparum	Plasmodium falciparum	IC50	2.5	nM	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	IC50	2.81	nM	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	IC50	3.0	nM	10.1016/s0960-894x(01)00798-3
Plasmodium falciparum	Plasmodium falciparum	IC50	3.66	nM	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	IC50	3.9	nM	10.1128/aac.00308-09
Plasmodium falciparum	Plasmodium falciparum	IC50	4.0	nM	10.1016/j.bmc.2021.116348
Plasmodium falciparum	Plasmodium falciparum	IC50	4.0	nM	10.1039/d2md00218c
Plasmodium falciparum	Plasmodium falciparum	IC50	4.083	ug.mL-1	10.1128/aac.00234-07
Plasmodium falciparum	Plasmodium falciparum	IC50	4.35	nM	10.1016/j.ejmech.2019.111983
Plasmodium falciparum	Plasmodium falciparum	IC50	4.7	nM	10.1016/j.ejmech.2021.113518
Plasmodium falciparum	Plasmodium falciparum	IC50	5.1	nM	10.1021/acs.jmedchem.8b01310
Plasmodium falciparum	Plasmodium falciparum	IC50	6.0	nM	10.1021/acs.jmedchem.1c00441
Plasmodium falciparum	Plasmodium falciparum	IC50	6.0	nM	10.1021/acs.jnatprod.7b00587
Plasmodium falciparum	Plasmodium falciparum	IC50	6.26	nM	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	IC50	7.7	nM	10.1021/acs.jnatprod.8b00956
Plasmodium falciparum	Plasmodium falciparum	IC50	8.0	nM	10.1016/j.bmcl.2017.03.065
Plasmodium falciparum	Plasmodium falciparum	IC50	8.0	nM	10.1021/acs.jnatprod.8b00154
Plasmodium falciparum	Plasmodium falciparum	IC50	8.45	nM	10.1016/j.bmcl.2016.05.039
Plasmodium falciparum	Plasmodium falciparum	IC50	8.95	nM	10.6019/CHEMBL2113921
Plasmodium falciparum	Plasmodium falciparum	IC50	9.0	nM	10.1016/j.ejmech.2017.02.024
Plasmodium falciparum	Plasmodium falciparum	IC50	9.9	nM	10.1021/acs.jnatprod.2c01041
Plasmodium falciparum	Plasmodium falciparum	IC50	10.0	nM	10.1016/j.ejmech.2014.10.061
Plasmodium falciparum	Plasmodium falciparum	IC50	10.0	nM	10.1016/j.ejmech.2017.03.007
Plasmodium falciparum	Plasmodium falciparum	IC50	10.0	nM	10.1021/ml3000808
Plasmodium falciparum	Plasmodium falciparum	IC50	10.01	nM	10.1128/aac.01144-06
Plasmodium falciparum	Plasmodium falciparum	IC50	10.2	nM	10.1021/jm970845u
Plasmodium falciparum	Plasmodium falciparum	IC50	10.4	nM	10.1039/C1MD00022E
Plasmodium falciparum	Plasmodium falciparum	IC50	10.85	nM	10.1021/jm500535j
Plasmodium falciparum	Plasmodium falciparum	IC50	10.9	nM	10.1021/jm500715u
Plasmodium falciparum	Plasmodium falciparum	IC50	11.0	nM	10.1016/j.bmcl.2020.127037
Plasmodium falciparum	Plasmodium falciparum	IC50	12.0	nM	10.1021/jm200227r
Plasmodium falciparum	Plasmodium falciparum	IC50	12.46	nM	10.1016/j.ejmech.2018.11.067
Plasmodium falciparum	Plasmodium falciparum	IC50	13.3	nM	10.1039/C1MD00022E
Plasmodium falciparum	Plasmodium falciparum	IC50	14.0	nM	10.1021/jm4004279
Plasmodium falciparum	Plasmodium falciparum	IC50	14.6	nM	10.1039/C1MD00022E
Plasmodium falciparum	Plasmodium falciparum	IC50	19.0	nM	10.1021/jm200227r
Plasmodium falciparum	Plasmodium falciparum	IC50	20.0	nM	10.1021/ml300008j
Plasmodium falciparum	Plasmodium falciparum	IC50	28.0	nM	10.1016/j.bmcl.2014.12.037
Plasmodium falciparum	Plasmodium falciparum	IC50	28.0	nM	10.1016/j.bmcl.2015.01.003
Plasmodium falciparum	Plasmodium falciparum	IC50	28.26	nM	10.1021/jm500535j
Plasmodium falciparum	Plasmodium falciparum	IC50	28.3	nM	10.1021/jm500715u
Plasmodium falciparum	Plasmodium falciparum	IC50	29.0	nM	10.1021/jm2003359
Plasmodium falciparum	Plasmodium falciparum	IC50	30.0	nM	10.1016/s0960-894x(02)01003-x
Plasmodium falciparum	Plasmodium falciparum	IC50	30.0	nM	10.1021/acs.jnatprod.7b00876
Plasmodium falciparum	Plasmodium falciparum	IC50	33.0	nM	10.1039/C7MD00052A
Plasmodium falciparum	Plasmodium falciparum	IC50	33.2	nM	10.6019/CHEMBL2113921
Plasmodium falciparum	Plasmodium falciparum	IC50	38.0	nM	10.1021/acs.jmedchem.7b00621
Plasmodium falciparum	Plasmodium falciparum	IC50	44.0	nM	10.1016/j.ejmech.2021.113518
Plasmodium falciparum	Plasmodium falciparum	IC50	44.1	nM	10.1128/aac.01144-06
Plasmodium falciparum	Plasmodium falciparum	IC50	45.0	nM	10.1021/acs.jmedchem.7b00621
Plasmodium falciparum	Plasmodium falciparum	IC50	47.0	nM	10.1016/j.bmc.2016.10.029
Plasmodium falciparum	Plasmodium falciparum	IC50	49.88	nM	10.1128/aac.01144-06
Plasmodium falciparum	Plasmodium falciparum	IC50	58.0	nM	10.1016/j.bmcl.2013.03.067
Plasmodium falciparum	Plasmodium falciparum	IC50	60.0	nM	10.1021/jm200227r
Plasmodium falciparum	Plasmodium falciparum	IC50	68.0	nM	10.1021/acs.jmedchem.5b00114
Plasmodium falciparum	Plasmodium falciparum	IC50	70.0	nM	10.1016/j.bmc.2012.10.019
Plasmodium falciparum	Plasmodium falciparum	IC50	80.0	nM	10.1016/j.bmc.2019.115158
Plasmodium falciparum	Plasmodium falciparum	IC50	80.0	nM	10.1021/acs.jnatprod.5b01054
Plasmodium falciparum	Plasmodium falciparum	IC50	80.0	nM	10.1021/acsmedchemlett.8b00389
Plasmodium falciparum	Plasmodium falciparum	IC50	80.0	nM	10.1021/jm010131q
Plasmodium falciparum	Plasmodium falciparum	IC50	120.0	nM	10.1016/j.bmcl.2016.05.039
Plasmodium falciparum	Plasmodium falciparum	IC50	142.61	nM	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	IC50	250.03	nM	10.1016/j.bmc.2019.06.038
Plasmodium falciparum	Plasmodium falciparum	IC50	371.0	nM	10.1128/aac.00308-09
Plasmodium falciparum	Plasmodium falciparum	IC50	371.0	nM	10.1128/aac.01526-09
Plasmodium falciparum	Plasmodium falciparum	IC50	467.34	nM	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	IC50	733.26	nM	10.1128/aac.00308-09
Plasmodium falciparum	Plasmodium falciparum	IC50	778.28	nM	10.1128/aac.00308-09
Plasmodium falciparum	Plasmodium falciparum	IC50	778.28	nM	10.1128/aac.01526-09
Plasmodium falciparum	Plasmodium falciparum	IC50	1005.0	nM	10.1016/j.bmc.2017.05.054
Plasmodium falciparum	Plasmodium falciparum	IC50	1005.0	nM	10.1016/j.bmc.2017.07.057
Plasmodium falciparum	Plasmodium falciparum	IC50	1146.0	nM	10.1021/jm200227r
Plasmodium falciparum	Plasmodium falciparum	IC50	2500.0	nM	10.1016/s0960-894x(00)00684-3
Plasmodium falciparum	Plasmodium falciparum	IC50	2500.0	nM	10.1016/s0960-894x(01)00798-3
Plasmodium falciparum	Plasmodium falciparum	IC50	2500.0	nM	10.1016/s0960-894x(02)00555-3
Plasmodium falciparum	Plasmodium falciparum	IC50	2500.0	nM	10.1016/s0960-894x(03)00179-3
Plasmodium falciparum	Plasmodium falciparum	IC50	2500.0	nM	10.1016/s0960-894x(03)00353-6
Plasmodium falciparum	Plasmodium falciparum	IC50	2512.0	nM	10.1128/aac.00282-08
Plasmodium falciparum	Plasmodium falciparum	IC50	3381.0	nM	10.1021/acs.jmedchem.7b00621
Plasmodium falciparum	Plasmodium falciparum	IC50	3690.79	nM	10.1128/aac.00308-09
Plasmodium falciparum	Plasmodium falciparum	IC50	3690.79	nM	10.1128/aac.01526-09
Plasmodium falciparum	Plasmodium falciparum	IC50	3900.0	nM	10.1021/acs.jnatprod.7b00876
Plasmodium falciparum	Plasmodium falciparum	IC50	5000.0	nM	10.1128/aac.01689-08
Plasmodium falciparum	Plasmodium falciparum	IC50	6929.14	nM	10.1128/aac.00308-09
Plasmodium falciparum	Plasmodium falciparum	IC50	8558.4	nM	10.1021/jm500715u
Plasmodium falciparum	Plasmodium falciparum	IC50	8558.42	nM	10.1021/jm500535j
Plasmodium falciparum	Plasmodium falciparum	IC50	8600.0	nM	10.1016/j.bmcl.2014.12.037
Plasmodium falciparum	Plasmodium falciparum	IC50	8600.0	nM	10.1016/j.bmcl.2015.01.003
Plasmodium falciparum	Plasmodium falciparum	IC50	9850.0	nM	10.6019/CHEMBL3392926
Plasmodium falciparum	Plasmodium falciparum	IC50	9900.0	nM	10.1021/jm200227r
Plasmodium falciparum	Plasmodium falciparum	IC50	10000.0	nM	10.1016/j.bmc.2017.10.017
Plasmodium falciparum	Plasmodium falciparum	IC50	10000.0	nM	10.1016/j.ejmech.2019.111983
Plasmodium falciparum	Plasmodium falciparum	IC50	10000.0	nM	10.1021/jm2003359
Plasmodium falciparum	Plasmodium falciparum	IC50	10041.7	nM	10.1021/jm500715u
Plasmodium falciparum	Plasmodium falciparum	IC50	10041.72	nM	10.1021/jm500535j
Plasmodium falciparum	Plasmodium falciparum	IC50	13838.59	nM	10.1021/jm500535j
Plasmodium falciparum	Plasmodium falciparum	IC50	13838.6	nM	10.1021/jm500715u
Plasmodium falciparum	Plasmodium falciparum	IC50	15379.7	nM	10.1021/jm500535j
Plasmodium falciparum	Plasmodium falciparum	IC50	15379.7	nM	10.1021/jm500715u
Plasmodium falciparum	Plasmodium falciparum	IC50	20000.0	nM	10.1021/acs.jmedchem.5b00114
Plasmodium falciparum	Plasmodium falciparum	IC50	20000.0	nM	10.1021/acs.jmedchem.7b00621
Plasmodium falciparum	Plasmodium falciparum	IC50	20000.0	nM	10.1126/science.1193225
Plasmodium falciparum	Plasmodium falciparum	IC50	29500.0	nM	10.1021/jm200227r
Plasmodium falciparum	Plasmodium falciparum	IC50	30900.0	nM	10.1021/acsmedchemlett.8b00389
Plasmodium falciparum	Plasmodium falciparum	IC50	31000.0	nM	10.1021/acs.jnatprod.5b01054
Plasmodium falciparum	Plasmodium falciparum	IC50	33000.0	nM	10.1016/j.ejmech.2014.01.040
Plasmodium falciparum	Plasmodium falciparum	IC50	33950.0	nM	10.1016/j.bmc.2016.10.029
Plasmodium falciparum	Plasmodium falciparum	IC50	40000.0	nM	10.1016/j.ejmech.2021.113518
Plasmodium falciparum	Plasmodium falciparum	IC50	40000.0	nM	10.1021/ml300008j
Plasmodium falciparum	Plasmodium falciparum	IC50	42000.0	nM	10.1021/acsmedchemlett.8b00389
Plasmodium falciparum	Plasmodium falciparum	IC50	60700.0	nM	10.1016/j.ejmech.2014.01.040
Plasmodium falciparum	Plasmodium falciparum	IC50	73500.0	nM	10.1021/acsmedchemlett.8b00389
Plasmodium falciparum	Plasmodium falciparum	IC50	85000.0	nM	10.1016/j.bmcl.2020.127037
Plasmodium falciparum	Plasmodium falciparum	IC50	100000.0	nM	10.1016/j.bmc.2010.01.068
Plasmodium falciparum	Plasmodium falciparum	IC50	100000.0	nM	10.1016/j.bmc.2019.115158
Plasmodium falciparum	Plasmodium falciparum	IC50	100000.0	nM	10.1016/j.bmcl.2013.03.067
Plasmodium falciparum	Plasmodium falciparum	IC50	100000.0	nM	10.1021/acsmedchemlett.8b00389
Plasmodium falciparum	Plasmodium falciparum	IC50	nan	None	10.1021/acs.jmedchem.7b00621
Plasmodium falciparum	Plasmodium falciparum	IC50	nan	None	10.1021/acs.jmedchem.8b01310
Plasmodium falciparum	Plasmodium falciparum	IC50	nan	None	10.1021/acs.jnatprod.8b00956
Plasmodium falciparum	Plasmodium falciparum	IC50	nan	None	10.1128/aac.01607-06
Plasmodium falciparum	Plasmodium falciparum	IC90	1.745	ug.mL-1	10.1021/jm010089z
Plasmodium falciparum	Plasmodium falciparum	Inhibition	0.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	5.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	40.0	%	10.1021/jm4004279
Plasmodium falciparum	Plasmodium falciparum	Inhibition	50.0	%	10.1021/jm400325j
Plasmodium falciparum	Plasmodium falciparum	Inhibition	62.0	%	10.1021/acs.jnatprod.5b00581
Plasmodium falciparum	Plasmodium falciparum	Inhibition	93.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	94.0	%	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	Inhibition	100.0	%	10.1021/jm4004279
Plasmodium falciparum	Plasmodium falciparum	log(activity)	3.1	None	10.1016/j.ejmech.2016.12.024
Plasmodium falciparum	Plasmodium falciparum	log(activity)	3.57	None	10.1021/acs.jmedchem.1c00821
Plasmodium falciparum	Plasmodium falciparum	log(activity)	4.1	None	10.1016/j.ejmech.2016.12.024
Plasmodium falciparum	Plasmodium falciparum	log(ratio)	2.9	None	10.1021/acs.jmedchem.7b00621
Plasmodium falciparum	Plasmodium falciparum	LT99.9	44.1	hr	10.1021/acs.jmedchem.1c00821
Plasmodium falciparum	Plasmodium falciparum	MIC	10.0	ug.mL-1	10.1016/j.bmcl.2005.02.015
Plasmodium falciparum	Plasmodium falciparum	MIC	10.0	ug.mL-1	10.1016/j.bmcl.2005.04.011
Plasmodium falciparum	Plasmodium falciparum	MIC	10.0	ug.mL-1	10.1016/j.bmcl.2005.04.014
Plasmodium falciparum	Plasmodium falciparum	MIC	10.0	ug.mL-1	10.1016/j.bmcl.2007.11.038
Plasmodium falciparum	Plasmodium falciparum	Potency	33.8	nM	None
Plasmodium falciparum	Plasmodium falciparum	Potency	65.7	nM	None
Plasmodium falciparum	Plasmodium falciparum	Potency	82.8	nM	None
Plasmodium falciparum	Plasmodium falciparum	Potency	4256.2	nM	None
Plasmodium falciparum	Plasmodium falciparum	Ratio	386.3	None	10.1021/jm010131q
Plasmodium falciparum	Plasmodium falciparum	Ratio IC50	6.0	None	10.1021/acs.jmedchem.6b01641
Plasmodium falciparum	Plasmodium falciparum	Ratio IC50	46.0	None	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	Ratio IC50	51.0	None	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	Ratio IC50	67.0	None	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	Ratio IC50	114.0	None	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	Ratio IC50	2000.0	None	10.1021/ml300008j
Plasmodium falciparum	Plasmodium falciparum	Ratio IC50	2592.0	None	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	Ratio IC50	8497.0	None	10.1128/aac.00628-10
Plasmodium falciparum	Plasmodium falciparum	Relative activity	0.1	None	10.1021/jm010131q
Plasmodium falciparum	Plasmodium falciparum	Relative activity	1.0	None	10.1021/jm010131q
Plasmodium falciparum	Plasmodium falciparum	Safety ratio	400.0	None	10.1021/jm010131q
Plasmodium falciparum	Plasmodium falciparum	Survival	11.0	%	10.1021/acs.jmedchem.8b00143
Plasmodium falciparum	Plasmodium falciparum	Survival	55.0	%	10.1021/acs.jmedchem.8b00143
Plasmodium falciparum	Plasmodium falciparum	T99.9%	61.0	hr	10.1021/acs.jmedchem.7b00621
Plasmodium falciparum	Plasmodium falciparum	TIME	24.0	hr	10.1021/acs.jmedchem.1c00821
Plasmodium falciparum	Plasmodium falciparum	TIME	24.0	hr	10.1021/acs.jmedchem.7b00621
Plasmodium falciparum	Plasmodium falciparum	XC50	31.81	nM	10.1038/nature09107
Plasmodium falciparum	Plasmodium falciparum	XC50	59.48	nM	10.1038/nature09107
Plasmodium falciparum (isolate 3D7)	Bifunctional dihydrofolate reductase-thymidylate synthase	IC50	2480.0	nM	10.1128/aac.00577-07
Plasmodium falciparum (isolate 3D7)	Bifunctional dihydrofolate reductase-thymidylate synthase	Ki	0.85	nM	10.1128/aac.00577-07
Plasmodium falciparum K1	Dihydrofolate reductase	IC50	25.5	nM	10.1016/j.bmc.2017.10.017
Plasmodium falciparum K1	Dihydrofolate reductase	IC50	58.0	nM	10.1016/j.bmc.2017.10.017
Plasmodium falciparum K1	Dihydrofolate reductase	IC50	80.0	nM	10.1016/j.bmcl.2006.05.047
Plasmodium falciparum K1	Dihydrofolate reductase	IC50	80.0	nM	10.1021/jm030165t
Plasmodium falciparum K1	Dihydrofolate reductase	IC50	30900.0	nM	10.1021/jm010131q
Plasmodium falciparum K1	Dihydrofolate reductase	IC50	41700.0	nM	10.1021/jm030165t
Plasmodium falciparum K1	Dihydrofolate reductase	IC50	73500.0	nM	10.1021/jm030165t
Plasmodium falciparum K1	Dihydrofolate reductase	IC50	100000.0	nM	10.1021/jm030165t
Plasmodium falciparum K1	Dihydrofolate reductase	Inhibition	nan	%	10.1016/j.bmc.2017.10.017
Plasmodium falciparum K1	Dihydrofolate reductase	Kd	nan	None	10.1021/jm00093a026
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	0.19	nM	10.1021/jm00093a026
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	0.6	nM	10.1021/jm010131q
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	0.6	nM	10.1021/jm030165t
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	0.87	nM	10.1021/jm040769c
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	1.4	nM	10.1021/jm030781p
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	1.5	nM	10.1021/jm030781p
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	1.5	nM	10.1021/jm970845u
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	2.0	nM	10.1021/jm00093a026
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	3.6	nM	10.1021/jm030781p
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	6.0	nM	10.1021/jm030781p
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	28.6	nM	10.1021/jm010131q
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	53.9	nM	10.1021/jm010131q
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	67.1	nM	10.1021/jm030165t
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	71.7	nM	10.1021/jm970845u
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	112.0	nM	10.1021/jm030165t
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	380.0	nM	10.1021/jm030781p
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	385.0	nM	10.1021/jm030165t
Plasmodium falciparum K1	Dihydrofolate reductase	Ki	860.0	nM	10.1021/jm030781p
Plasmodium falciparum K1	Dihydrofolate reductase	Ratio	47.7	None	10.1021/jm010131q
Plasmodium falciparum K1	Dihydrofolate reductase	Ratio	89.8	None	10.1021/jm010131q
Plasmodium falciparum K1	Dihydrofolate reductase	Ratio	111.8	None	10.1021/jm030165t
Plasmodium falciparum K1	Dihydrofolate reductase	Ratio	186.7	None	10.1021/jm030165t
Plasmodium falciparum K1	Dihydrofolate reductase	Ratio	641.7	None	10.1021/jm030165t
Plasmodium falciparum K1	Dihydrofolate reductase	Ratio	nan	None	10.1021/jm00093a026
Plasmodium falciparum K1	Dihydrofolate reductase	Relative activity	1.0	None	10.1021/jm010131q
Plasmodium falciparum K1	Plasmodium falciparum K1	IC50	11900.0	nM	10.6019/CHEMBL2113921
Plasmodium gallinaceum	Plasmodium gallinaceum	Activity	nan	None	10.1021/jm00208a010
Plasmodium malariae	Plasmodium malariae	IC50	0.00224	ug.mL-1	10.1128/aac.00234-07
Plasmodium vivax	Plasmodium vivax	CD90	0.625	mg kg-1	10.1021/jm00196a019
Plasmodium vivax	Plasmodium vivax	IC50	0.008	ug.mL-1	10.1128/aac.00234-07
Plasmodium yoelii	Plasmodium yoelii	Activity	nan	None	10.1021/acs.jmedchem.6b01733
Plasmodium yoelii	Plasmodium yoelii	Activity	nan	None	10.1126/science.1211936
Plasmodium yoelii	Plasmodium yoelii	GI	98.4	%	10.1021/acs.jmedchem.6b01733
Plasmodium yoelii	Plasmodium yoelii	GI	100.0	%	10.1021/acs.jmedchem.6b01733
Plasmodium yoelii	Plasmodium yoelii	IC50	2.152	nM	10.1126/science.1211936
Plasmodium yoelii	Plasmodium yoelii	IC50	1000.0	nM	10.1021/jm400325j
Plasmodium yoelii	Plasmodium yoelii	Schizont size	37.58	um	10.1126/science.1211936
Plasmodium yoelii	Plasmodium yoelii	Survival	100.0	%	10.1021/acs.jmedchem.6b01733
Plasmodium yoelii	Plasmodium yoelii	TIME	96.0	hr	10.1021/acs.jmedchem.6b01733
Plasmodium yoelii	Plasmodium yoelii	TIME	408.0	hr	10.1021/acs.jmedchem.6b01733
Plasmodium yoelii	Plasmodium yoelii	TIME	720.0	hr	10.1021/acs.jmedchem.6b01733
Pneumocystis carinii	Dihydrofolate reductase	IC50	2400.0	nM	10.1021/jm400086g
Pneumocystis carinii	Dihydrofolate reductase	IC50	2400.0	nM	10.1021/jm970614n
Pneumocystis carinii	Dihydrofolate reductase	IC50	2800.0	nM	10.1021/jm00024a001
Pneumocystis carinii	Dihydrofolate reductase	IC50	3650.0	nM	10.1021/jm950760y
Pneumocystis carinii	Dihydrofolate reductase	IC50	3650.0	nM	10.1021/jm970050n
Pneumocystis carinii	Dihydrofolate reductase	IC50	3700.0	nM	10.1021/jm00005a002
Pneumocystis carinii	Dihydrofolate reductase	IC50	3700.0	nM	10.1021/jm00052a011
Pneumocystis carinii	Dihydrofolate reductase	IC50	3700.0	nM	10.1021/jm970399a
Pneumocystis carinii	Dihydrofolate reductase	IC50	nan	None	10.1016/j.bmcl.2006.05.047
Pneumocystis carinii	Dihydrofolate reductase	Ki	9.7	nM	10.1021/jm00024a001
Pneumocystis carinii	Dihydrofolate reductase; P. carinii vs rat	Ratio	0.62	None	10.1021/jm00052a011
Pneumocystis carinii	Dihydrofolate reductase; P. carinii vs rat	Selectivity	0.62	None	10.1021/jm00005a002
Pneumocystis carinii	Dihydrofolate reductase; P. carinii vs rat	Selectivity	0.63	None	10.1021/jm950760y
Pneumocystis carinii	Dihydrofolate reductase; P. carinii vs rat	Selectivity index	0.63	None	10.1021/jm970050n
Pneumocystis carinii	Dihydrofolate reductase; P. carinii vs rat	Selectivity ratio	0.63	None	10.1021/jm0108698
Pneumocystis carinii	Pneumocystis carinii	IC50	0.0	nM	10.1016/j.bmc.2010.01.068
Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC	10000.0	nM	10.6019/CHEMBL4513141
Punta Toro virus	Punta Toro virus	EC50	100000.0	nM	10.1016/j.ejmech.2017.04.070
Rattus norvegicus	Androgen Receptor	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Cyclooxygenase-1	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Dihydrofolate reductase	IC50	1400.0	nM	10.1021/jm00131a009
Rattus norvegicus	Dihydrofolate reductase	IC50	1500.0	nM	10.1021/jm400086g
Rattus norvegicus	Dihydrofolate reductase	IC50	1500.0	nM	10.1021/jm970614n
Rattus norvegicus	Dihydrofolate reductase	IC50	2300.0	nM	10.1021/jm00005a002
Rattus norvegicus	Dihydrofolate reductase	IC50	2300.0	nM	10.1021/jm00024a001
Rattus norvegicus	Dihydrofolate reductase	IC50	2300.0	nM	10.1021/jm00052a011
Rattus norvegicus	Dihydrofolate reductase	IC50	2300.0	nM	10.1021/jm0108698
Rattus norvegicus	Dihydrofolate reductase	IC50	2300.0	nM	10.1021/jm950760y
Rattus norvegicus	Dihydrofolate reductase	IC50	2300.0	nM	10.1021/jm970050n
Rattus norvegicus	Dihydrofolate reductase	IC50	2300.0	nM	10.1021/jm970399a
Rattus norvegicus	GABA receptor alpha-1 subunit	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Glutamate (NMDA) receptor subunit zeta 1	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Rattus norvegicus	Nuclear receptor subfamily 1 group I member 2	Potency	50118.7	nM	None
Rattus norvegicus	Peripheral myelin protein 22	Potency	9992.4	nM	None
Rattus norvegicus	Rattus norvegicus	Pc	0.00012	cm s-1	10.1021/jm00180a022
Rattus norvegicus	Voltage-gated L-type calcium channel alpha-1C subunit	AC50	10000.0	nM	10.1038/s41467-023-40064-9
Respiratory syncytial virus	Respiratory syncytial virus	EC50	750.0	nM	10.1016/j.ejmech.2017.04.070
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	15.45	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	15.51	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Hit score	0.2473	None	10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50	19952.62	nM	10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50	20000.0	nM	10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	0.1	%	10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	9.02	%	10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	57.63	%	10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition index	0.7421	None	10.1101/2020.04.03.023846
Sindbis virus	Sindbis virus	EC50	8900.0	nM	10.1016/j.ejmech.2017.04.070
Staphylococcus aureus	Staphylococcus aureus	MIC	5000.0	nM	10.6019/CHEMBL4513141
Streptococcus	Streptococcus	EC50	51168.0	nM	None
Streptococcus pyogenes serotype M1	Streptokinase A	EC50	3992.0	nM	None
Streptococcus pyogenes serotype M1	Streptokinase A	EC50	150000.0	nM	None
Streptococcus sp. 'group A'	Streptococcus sp. 'group A'	EC50	3094.0	nM	None
Toxoplasma gondii	Dihydrofolate reductase	IC50	80.0	nM	10.1021/jm800244v
Toxoplasma gondii	Dihydrofolate reductase	IC50	139.0	nM	10.1021/acs.jmedchem.8b01754
Toxoplasma gondii	Dihydrofolate reductase	IC50	200.0	nM	10.1016/j.bmc.2012.05.068
Toxoplasma gondii	Dihydrofolate reductase	IC50	230.0	nM	10.1021/acsmedchemlett.6b00328
Toxoplasma gondii	Dihydrofolate reductase	IC50	390.0	nM	10.1021/jm00005a002
Toxoplasma gondii	Dihydrofolate reductase	IC50	390.0	nM	10.1021/jm00052a011
Toxoplasma gondii	Dihydrofolate reductase	IC50	390.0	nM	10.1021/jm0108698
Toxoplasma gondii	Dihydrofolate reductase	IC50	390.0	nM	10.1021/jm950760y
Toxoplasma gondii	Dihydrofolate reductase	IC50	390.0	nM	10.1021/jm970050n
Toxoplasma gondii	Dihydrofolate reductase	IC50	390.0	nM	10.1021/jm970399a
Toxoplasma gondii	Dihydrofolate reductase	IC50	390.0	nM	10.1021/jm970614n
Toxoplasma gondii	Dihydrofolate reductase	IC50	390.0	nM	10.1021/jm980572i
Toxoplasma gondii	Dihydrofolate reductase; T. gondii vs rat	Ratio	5.9	None	10.1021/jm00052a011
Toxoplasma gondii	Dihydrofolate reductase; T. gondii vs rat	Selectivity	5.9	None	10.1021/jm950760y
Toxoplasma gondii	Dihydrofolate reductase; T. gondii vs rat	Selectivity	7.7	None	10.1021/jm00005a002
Toxoplasma gondii	Dihydrofolate reductase; T. gondii vs rat	Selectivity ratio	5.9	None	10.1021/jm0108698
Toxoplasma gondii	Toxoplasma gondii	Activity	14.0	None	10.1016/j.ejmech.2022.114812
Toxoplasma gondii	Toxoplasma gondii	Activity	23.0	%	10.1016/j.bmc.2010.04.003
Toxoplasma gondii	Toxoplasma gondii	Activity	25.0	%	10.1016/j.bmc.2010.04.003
Toxoplasma gondii	Toxoplasma gondii	Activity	35.0	%	10.1021/acs.jmedchem.8b01754
Toxoplasma gondii	Toxoplasma gondii	Activity	40.0	%	10.1128/aac.00680-07
Toxoplasma gondii	Toxoplasma gondii	Activity	55.0	%	10.1016/j.bmc.2010.04.003
Toxoplasma gondii	Toxoplasma gondii	Activity	99.0	%	10.1016/j.bmc.2010.04.003
Toxoplasma gondii	Toxoplasma gondii	Activity	100.0	%	10.1016/j.bmc.2010.04.003
Toxoplasma gondii	Toxoplasma gondii	Activity	100.0	%	10.1021/acs.jmedchem.8b01754
Toxoplasma gondii	Toxoplasma gondii	Activity	101.0	%	10.1016/j.bmc.2010.04.003
Toxoplasma gondii	Toxoplasma gondii	Activity	108.0	%	10.1016/j.bmc.2010.04.003
Toxoplasma gondii	Toxoplasma gondii	Activity	nan	None	10.1016/j.bmc.2021.116467
Toxoplasma gondii	Toxoplasma gondii	Activity	nan	None	10.1016/j.ejmech.2022.114812
Toxoplasma gondii	Toxoplasma gondii	Activity	nan	None	10.1021/acs.jmedchem.7b01192
Toxoplasma gondii	Toxoplasma gondii	Activity	nan	None	10.1021/acs.jmedchem.8b01754
Toxoplasma gondii	Toxoplasma gondii	Activity	nan	None	10.1021/jm4001314
Toxoplasma gondii	Toxoplasma gondii	EC50	210.0	nM	10.1128/aac.00582-07
Toxoplasma gondii	Toxoplasma gondii	EC50	240.0	nM	10.1128/aac.00582-07
Toxoplasma gondii	Toxoplasma gondii	EC50	270.0	nM	10.1128/aac.00582-07
Toxoplasma gondii	Toxoplasma gondii	EC50	290.0	nM	10.1128/aac.00582-07
Toxoplasma gondii	Toxoplasma gondii	EC50	340.0	nM	10.1016/j.ejmech.2015.10.004
Toxoplasma gondii	Toxoplasma gondii	EC50	680.0	nM	10.1021/acs.jmedchem.8b01754
Toxoplasma gondii	Toxoplasma gondii	GI	nan	None	10.1016/j.ejmech.2017.11.069
Toxoplasma gondii	Toxoplasma gondii	IC50	0.0	nM	10.1016/j.bmc.2010.01.068
Toxoplasma gondii	Toxoplasma gondii	IC50	0.07	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.09	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.1	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.11	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.12	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.14	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.15	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.17	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.18	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.19	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.25	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.34	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.35	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	0.39	ug.mL-1	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	IC50	120.0	nM	10.1039/C1MD00022E
Toxoplasma gondii	Toxoplasma gondii	IC50	240.0	nM	10.1039/C1MD00022E
Toxoplasma gondii	Toxoplasma gondii	IC50	400.0	nM	10.1021/jm950760y
Toxoplasma gondii	Toxoplasma gondii	IC50	453.0	nM	10.1021/acs.jmedchem.1c01569
Toxoplasma gondii	Toxoplasma gondii	IC50	570.0	nM	10.1021/ml400208v
Toxoplasma gondii	Toxoplasma gondii	IC50	700.0	nM	10.1016/j.bmc.2009.12.066
Toxoplasma gondii	Toxoplasma gondii	IC50	800.0	nM	10.1016/j.bmcl.2011.06.113
Toxoplasma gondii	Toxoplasma gondii	IC50	800.0	nM	10.1016/j.bmcl.2019.126778
Toxoplasma gondii	Toxoplasma gondii	IC50	800.0	nM	10.1016/j.ejmech.2012.04.029
Toxoplasma gondii	Toxoplasma gondii	IC50	1100.0	nM	10.1016/j.ejmech.2011.06.021
Toxoplasma gondii	Toxoplasma gondii	IC50	1500.0	nM	10.1016/j.ejmech.2009.11.005
Toxoplasma gondii	Toxoplasma gondii	IC50	2000.0	nM	10.1016/j.bmc.2009.05.022
Toxoplasma gondii	Toxoplasma gondii	IC50	2000.0	nM	10.1016/j.ejmech.2015.03.011
Toxoplasma gondii	Toxoplasma gondii	IC50	3620.0	nM	10.1021/acs.jmedchem.1c01569
Toxoplasma gondii	Toxoplasma gondii	IC50	5900.0	nM	10.1021/jm800201s
Toxoplasma gondii	Toxoplasma gondii	IC50	nan	None	10.1128/aac.01203-07
Toxoplasma gondii	Toxoplasma gondii	Ratio	22.0	None	10.1021/jm101593u
Toxoplasma gondii	Toxoplasma gondii	Ratio	23.0	None	10.1021/jm101593u
Toxoplasma gondii	Toxoplasma gondii	Ratio	27.0	None	10.1021/jm101593u
Toxoplasma gondii	Toxoplasma gondii	Ratio	29.0	None	10.1021/jm101593u
Toxoplasma gondii	Toxoplasma gondii	Survival	5.8	%	10.1021/jm800201s
Toxoplasma gondii	Toxoplasma gondii	Survival	6.9	%	10.1021/jm030537y
Toxoplasma gondii	Toxoplasma gondii	Survival	11.8	%	10.1021/jm030537y
Toxoplasma gondii	Toxoplasma gondii	Survival	13.8	%	10.1021/jm800201s
Toxoplasma gondii	Toxoplasma gondii	Survival	36.3	%	10.1021/jm030537y
Toxoplasma gondii	Toxoplasma gondii	Survival	36.5	%	10.1021/jm800201s
Toxoplasma gondii	Toxoplasma gondii	Survival	53.8	%	10.1021/jm030537y
Toxoplasma gondii	Toxoplasma gondii	Survival	55.6	%	10.1021/jm800201s
Toxoplasma gondii	Toxoplasma gondii	Survival	100.0	%	10.1021/jm030537y
Trypanosoma brucei	Trypanosoma brucei	IC50	7000.0	nM	10.1021/jm981130+
Trypanosoma brucei brucei	Trypanosoma brucei brucei	ED50	26.6	uM	10.1021/jm901059x
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense	IC50	6750.0	nM	10.6019/CHEMBL3392926
Trypanosoma cruzi	Trypanosoma cruzi	IC50	5710.0	nM	10.6019/CHEMBL3392926
Vesicular stomatitis virus	Vesicular stomatitis virus	EC50	100000.0	nM	10.1016/j.ejmech.2017.04.070
Yellow fever virus	Yellow fever virus	EC50	100000.0	nM	10.1016/j.ejmech.2017.04.070
None	ADMET	Activity	60.0	%	10.1021/jm5017895
None	ADMET	Activity	nan	None	10.1016/j.ejmech.2022.114812
None	ADMET	Activity	nan	None	10.1021/jm5017895
None	ADMET	Binding energy	9.7	kCal mol-1	10.1021/jm00378a021
None	ADMET	Biotransformation	nan	None	10.1038/s41586-019-1291-3
None	ADMET	CL	0.052	mL.min-1.kg-1	10.1124/dmd.108.020479
None	ADMET	CL	8.6	mL.min-1.kg-1	10.1021/acs.jmedchem.8b01754
None	ADMET	IC50	16100.0	nM	10.1016/j.bmc.2010.04.003
None	ADMET	IC50	nan	None	10.1021/ml3000808
None	ADMET	LD50	nan	None	10.1039/C1MD00022E
None	ADMET	MRT	140.0	hr	10.1124/dmd.108.020479
None	ADMET	MTD	2.5	mg kg-1	10.1021/jm00196a019
None	ADMET	Papp	36.0	10'-6 cm/s	10.1021/acs.jmedchem.8b01754
None	ADMET	PPB	92.64	%	10.6019/CHEMBL3301361
None	ADMET	PPB	93.1	%	10.6019/CHEMBL3301361
None	ADMET	Ratio	0.83	None	10.1021/acs.jmedchem.8b01754
None	ADMET	Ratio IC50	955.0	None	10.1016/j.bmcl.2016.05.039
None	ADMET	Ratio IC50	1013.0	None	10.1021/acs.jnatprod.2c01041
None	ADMET	Ratio IC50	7500.0	None	10.1039/d2md00218c
None	ADMET	Survival	100.0	%	10.1021/jm800201s
None	ADMET	Survival	101.0	%	10.1021/jm800201s
None	ADMET	Survival	108.0	%	10.1021/jm800201s
None	ADMET	T1/2	140.0	hr	10.1124/dmd.108.020479
None	ADMET	Vdss	0.43	L.kg-1	10.1124/dmd.108.020479
None	BC	IC50	40000.0	nM	10.1021/jm030165t
None	BC	IC50	250000.0	nM	10.1021/jm010131q
None	BC	Safety ratio	1.0	None	10.1021/jm030165t
None	BC	Safety ratio	500.0	None	10.1021/jm030165t
None	BC1 cell line	IC50	5098.05	nM	10.6019/CHEMBL1201861
None	Hepatotoxicity	Hepatotoxicity	nan	None	10.1021/tx1000865
None	Hepatotoxicity	Hepatotoxicity	nan	None	10.1021/tx900326k
None	Hepatotoxicity	Hepatotoxicity	nan	None	10.1124/dmd.110.035113
None	Hepatotoxicity	HepSE_bilirubinemia	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cholecystitis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cholelithiasis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cirrhosis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_Combined Scores	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_elevated liver function tests	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatic failure	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatic necrosis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatitis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatomegaly	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_jaundice	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver disease	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver fatty	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver function tests abnormal	0.0	None	10.1371/journal.pcbi.1002310
None	Molecular identity unknown	Potency	11220.2	nM	None
None	Molecular identity unknown	Potency	50118.7	nM	None
None	NON-PROTEIN TARGET	AbsAC35_uM	6.43	uM	None
None	NON-PROTEIN TARGET	AbsAC35_uM	15.9	uM	None
None	NON-PROTEIN TARGET	Fu	0.095	None	10.1124/dmd.108.020479
None	NON-PROTEIN TARGET	Hepatotoxicity (acute)	0.0	%	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (animal toxicity known)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (benign tumour)	0.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (granulomatous hepatitis)	1.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (mechanism)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (moderate)	8.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (moderate)	28.6	%	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (time to onset)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	IC50	2510.0	nM	10.6019/CHEMBL3392926
None	NON-PROTEIN TARGET	IC50	4000.0	nM	10.1021/jm00212a010
None	NON-PROTEIN TARGET	IC50	12000.0	nM	10.1021/jm00212a010
None	NON-PROTEIN TARGET	IC50	12060.0	nM	10.6019/CHEMBL3392926
None	NON-PROTEIN TARGET	IC50	nan	None	10.1016/j.bmc.2016.10.029
None	NON-PROTEIN TARGET	Inhibition	nan	%	10.1021/jm00212a010
None	NON-PROTEIN TARGET	Potency	1.5	nM	None
None	NON-PROTEIN TARGET	Potency	3.3	nM	None
None	NON-PROTEIN TARGET	Potency	133.2	nM	None
None	NON-PROTEIN TARGET	Potency	10583.9	nM	None
None	NON-PROTEIN TARGET	Potency	13324.4	nM	None
None	NON-PROTEIN TARGET	Ratio	270.0	None	10.1021/jm00134a002
None	NON-PROTEIN TARGET	Safety ratio	1.03	None	10.1021/jm010131q
None	NON-PROTEIN TARGET	Safety ratio	3.5	None	10.1021/jm010131q
None	NON-PROTEIN TARGET	Safety ratio	8.1	None	10.1021/jm010131q
None	NON-PROTEIN TARGET	Safety ratio	1362.5	None	10.1021/jm010131q
None	NON-PROTEIN TARGET	Safety ratio	3125.0	None	10.1021/jm010131q
None	No relevant target	LogD	0.76	None	10.1016/j.bmc.2012.10.019
None	No relevant target	LogD	1.93	None	10.1016/j.bmc.2012.10.019
None	No relevant target	LogD7.4	2.31	None	10.6019/CHEMBL3301361
None	No relevant target	LogP	2.69	None	10.1021/jm00180a022
None	No relevant target	Log Pmic	2.51	None	10.1021/jm960068i
None	No relevant target	pKa	7.36	None	10.1016/j.bmc.2012.10.019
None	No relevant target	solubility	nan	None	10.1016/j.ejmech.2014.12.051
None	No relevant target	Solubility	19.4	ug.mL-1	10.1016/j.bmc.2010.08.003
None	No relevant target	Solubility	150.0	nM	10.1016/j.bmc.2012.10.019
None	No relevant target	Solubility	1160.0	nM	10.1016/j.bmc.2012.10.019
None	No relevant target	Solubility	6670.0	nM	10.1016/j.bmc.2012.10.019
None	No relevant target	Solubility	12830.0	nM	10.1016/j.bmc.2012.10.019
None	No relevant target	Solubility	184000.0	nM	10.1021/acs.jmedchem.8b01754
None	Unchecked	AbsAC35	5.12	uM	None
None	Unchecked	AbsAC35_uM	8.71	uM	None
None	Unchecked	Ac50	1.259	uM	None
None	Unchecked	Ac50	1.778	uM	None
None	Unchecked	Ac50	22.39	uM	None
None	Unchecked	Ac50	31.62	uM	None
None	Unchecked	Ac50	39.81	uM	None
None	Unchecked	AC50	1258.9	nM	None
None	Unchecked	AC50	1780.0	nM	None
None	Unchecked	AC50	22387.2	nM	None
None	Unchecked	AC50	23010.0	nM	None
None	Unchecked	AC50	31622.8	nM	None
None	Unchecked	AC50	39810.7	nM	None
None	Unchecked	EC50	200.0	nM	None
None	Unchecked	EC50	1100.0	nM	10.1016/j.ejmech.2017.04.070
None	Unchecked	EC50	3815.0	nM	None
None	Unchecked	EC50	10480.0	nM	None
None	Unchecked	EC50	10550.0	nM	None
None	Unchecked	EC50	83000.0	nM	10.1016/j.ejmech.2017.04.070
None	Unchecked	Hepatotoxicity (acute)	1.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (association with vascular disease)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (choleostasis)	1.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (chronic liver disease)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (cirrhosis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (comment)	nan	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (cytolytic)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (malignant tumour)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (severe hepatitis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (steatosis)	1.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (successful reintroduction)	nan	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	IC50	1.6	nM	10.1016/j.bmcl.2004.12.049
None	Unchecked	IC50	5.0	nM	10.1016/j.bmcl.2004.12.049
None	Unchecked	IC50	10.0	nM	10.1128/aac.00577-07
None	Unchecked	IC50	20.0	nM	10.1016/j.bmcl.2011.12.011
None	Unchecked	IC50	50.0	nM	10.1128/aac.00384-08
None	Unchecked	IC50	67.7	nM	None
None	Unchecked	IC50	90.0	nM	10.1021/acs.jmedchem.8b02021
None	Unchecked	IC50	90.0	nM	10.1128/aac.00577-07
None	Unchecked	IC50	130.0	nM	10.1021/jm400086g
None	Unchecked	IC50	150.0	nM	10.1021/jm400086g
None	Unchecked	IC50	170.0	nM	10.1128/aac.00577-07
None	Unchecked	IC50	420.0	nM	10.1128/aac.00577-07
None	Unchecked	IC50	670.0	nM	10.1021/jm980572i
None	Unchecked	IC50	860.0	nM	None
None	Unchecked	IC50	870.0	nM	10.1128/aac.00577-07
None	Unchecked	IC50	1820.0	nM	10.1128/aac.00577-07
None	Unchecked	IC50	2000.0	nM	10.1074/jbc.m609304200
None	Unchecked	IC50	2800.0	nM	10.1016/j.ejmech.2015.03.011
None	Unchecked	IC50	3470.0	nM	10.1128/aac.00577-07
None	Unchecked	IC50	3650.0	nM	10.1021/jm0108698
None	Unchecked	IC50	3900.0	nM	10.1021/ml400208v
None	Unchecked	IC50	5000.0	nM	10.1074/jbc.m609304200
None	Unchecked	IC50	7200.0	nM	10.1128/aac.00577-07
None	Unchecked	IC50	10000.0	nM	None
None	Unchecked	IC50	20100.0	nM	10.1016/j.ejmech.2021.113378
None	Unchecked	IC50	80000.0	nM	None
None	Unchecked	IC50	150000.0	nM	None
None	Unchecked	IC90	6.0	nM	10.1016/j.bmcl.2004.12.049
None	Unchecked	IC90	28.0	nM	10.1016/j.bmcl.2004.12.049
None	Unchecked	IFI	1.59	%	10.1038/nature09107
None	Unchecked	IFI	3.57	%	10.1038/nature09107
None	Unchecked	IFI	4.118	%	10.1073/pnas.0802982105
None	Unchecked	Inhibition	25.0	%	10.1016/j.bmc.2016.10.029
None	Unchecked	Inhibition	98.9	%	10.1016/j.bmcl.2011.12.011
None	Unchecked	Inhibition	nan	%	10.1128/aac.00384-08
None	Unchecked	Ki	0.59	nM	10.1128/aac.01526-09
None	Unchecked	Ki	0.6	nM	10.1016/j.bmc.2019.115158
None	Unchecked	Ki	0.6	nM	10.1021/acsmedchemlett.8b00389
None	Unchecked	Ki	1.07	nM	10.1128/aac.00577-07
None	Unchecked	Ki	1.24	nM	10.1128/aac.00577-07
None	Unchecked	Ki	1.9	nM	10.1128/aac.00577-07
None	Unchecked	Ki	2.1	nM	10.1128/aac.00577-07
None	Unchecked	Ki	3.57	nM	10.1128/aac.00577-07
None	Unchecked	Ki	7.26	nM	10.1128/aac.00577-07
None	Unchecked	Ki	15.5	nM	10.1128/aac.00577-07
None	Unchecked	Ki	53.9	nM	10.1021/acsmedchemlett.8b00389
None	Unchecked	Ki	67.1	nM	10.1021/acsmedchemlett.8b00389
None	Unchecked	Ki	75.0	nM	10.1016/j.bmc.2019.04.032
None	Unchecked	Ki	112.0	nM	10.1021/acsmedchemlett.8b00389
None	Unchecked	Ki	385.0	nM	10.1016/j.bmc.2019.115158
None	Unchecked	Ki	385.0	nM	10.1128/aac.01526-09
None	Unchecked	Ki	390.0	nM	10.1021/acsmedchemlett.8b00389
None	Unchecked	Ki	13000.0	nM	10.1074/jbc.m609304200
None	Unchecked	Ki	nan	None	10.1128/aac.00577-07
None	Unchecked	Max_Activity	26.0	uM	None
None	Unchecked	Potency	707.9	nM	None
None	Unchecked	Potency	1000.0	nM	None
None	Unchecked	Potency	1158.2	nM	None
None	Unchecked	Potency	5173.5	nM	None
None	Unchecked	Potency	7079.5	nM	None
None	Unchecked	Potency	8912.5	nM	None
None	Unchecked	Potency	10000.0	nM	None
None	Unchecked	Potency	14125.4	nM	None
None	Unchecked	Potency	15848.9	nM	None
None	Unchecked	Potency	17782.8	nM	None
None	Unchecked	Potency	22387.2	nM	None
None	Unchecked	Potency	28183.8	nM	None
None	Unchecked	Potency	31622.8	nM	None
None	Unchecked	Potency	50118.7	nM	None
None	Unchecked	Ratio	0.15	None	10.1021/jm010131q
None	Unchecked	Ratio	0.8	None	10.1016/j.bmc.2019.04.032
None	Unchecked	Ratio	1.7	None	10.1021/jm980572i
None	Unchecked	Ratio	13.0	None	10.1021/jm010131q
None	Unchecked	Ratio	47.8	None	10.1021/jm970845u
None	Unchecked	Ratio	100.0	None	10.1021/jm901059x
None	Unchecked	Ratio CC50/IC50	1960.0	None	10.1021/acs.jmedchem.8b01310
None	Unchecked	Ratio EC50	17.0	None	10.1021/acs.jmedchem.8b01754
None	Unchecked	Ratio IC50	0.02	None	10.1128/aac.00577-07
None	Unchecked	Ratio IC50	0.2	None	10.1128/aac.00577-07
None	Unchecked	Ratio IC50	0.32	None	10.1016/j.bmc.2019.115158
None	Unchecked	Ratio IC50	0.6	None	10.1021/jm400086g
None	Unchecked	Ratio IC50	1.8	None	10.1016/j.ejmech.2014.01.040
None	Unchecked	Ratio IC50	2.1	None	10.1128/aac.00577-07
None	Unchecked	Ratio IC50	3.0	None	10.1021/jm00212a010
None	Unchecked	Ratio IC50	3.0	None	10.1021/jm800244v
None	Unchecked	Ratio IC50	3.1	None	10.1021/jm400086g
None	Unchecked	Ratio IC50	4.3	None	10.1128/aac.00577-07
None	Unchecked	Ratio IC50	5.9	None	10.1021/ml400208v
None	Unchecked	Ratio IC50	5.9	None	10.1128/aac.00577-07
None	Unchecked	Ratio IC50	7.6	None	10.1021/acs.jmedchem.8b01754
None	Unchecked	Ratio IC50	8.0	None	10.1016/j.ejmech.2014.01.040
None	Unchecked	Ratio IC50	8.3	None	10.1128/aac.00577-07
None	Unchecked	Ratio IC50	10.0	None	10.1021/jm400086g
None	Unchecked	Ratio IC50	12.0	None	10.1021/acs.jmedchem.8b01754
None	Unchecked	Ratio IC50	15.0	None	10.1021/jm500715u
None	Unchecked	Ratio IC50	20.0	None	10.1021/acsmedchemlett.6b00328
None	Unchecked	Ratio IC50	42.0	None	10.1128/aac.00577-07
None	Unchecked	Ratio IC50	75.0	None	10.1021/jm800244v
None	Unchecked	Ratio IC50	120.0	None	10.1021/acs.jnatprod.7b00587
None	Unchecked	Ratio IC50	400.0	None	10.1016/j.bmc.2019.115158
None	Unchecked	Ratio IC50	1010.0	None	10.1021/acs.jnatprod.2c01041
None	Unchecked	Ratio IC50	1111.1	None	10.1016/j.ejmech.2017.02.024
None	Unchecked	Ratio IC50	1688.0	None	10.1021/acs.jnatprod.6b00759
None	Unchecked	Ratio IC50	1688.0	None	10.1021/acs.jnatprod.9b00721
None	Unchecked	Ratio IC50	1820.0	None	10.1021/ml3000808
None	Unchecked	Ratio IC50	8000.0	None	10.1016/j.ejmech.2021.113518
None	Unchecked	Ratio IC50	nan	None	10.1021/acs.jnatprod.8b00956
None	Unchecked	Ratio IC50	nan	None	10.1021/ml300008j
None	Unchecked	Ratio IC50	nan	None	10.1039/C7MD00052A
None	Unchecked	Ratio Ki	0.07	None	10.1016/j.bmc.2019.115158
None	Unchecked	Ratio Ki	0.07	None	10.1021/acsmedchemlett.8b00389
None	Unchecked	Ratio Ki	47.17	None	10.1016/j.bmc.2019.115158
None	Unchecked	Ratio Ki	52.0	None	10.1128/aac.01526-09
None	Unchecked	Ratio Ki	641.67	None	10.1016/j.bmc.2019.115158
None	Unchecked	Ratio Ki	652.0	None	10.1128/aac.01526-09
None	Unchecked	Selectivity	0.6	None	10.1021/jm00024a001
None	Unchecked	Selectivity index	5.9	None	10.1021/jm970050n
None	Unchecked	Selectivity ratio	0.62	None	10.1021/jm970399a
None	Unchecked	Selectivity ratio	0.62	None	10.1021/jm970614n
None	Unchecked	Selectivity ratio	5.9	None	10.1021/jm970399a
None	Unchecked	Selectivity ratio	5.9	None	10.1021/jm970614n
None	Unchecked	Survival	98.8	%	10.1021/jm030537y
None	Unchecked	Survival	100.0	%	10.1021/jm030537y