(-)-Norargemonine
AlkaPlorer ID: AK062987
Synonym: 'O8-Demethylargemonine', 'O2-Demetylargemonie', 'Norargemonine'
IUPAC Name: (1S,9S)-5,12,13-trimethoxy-17-methyl-17-azatetracyclo[7.7.1.02,7.010,15]heptadeca-2,4,6,10,12,14-hexaen-4-ol
Structure
SMILES: COC1=CC2=C(C=C1O)[C@@H]1CC3=CC(OC)=C(OC)C=C3[C@H](C2)N1C
InChI: InChI=1S/C20H23NO4/c1-21-15-6-12-8-19(24-3)20(25-4)10-14(12)16(21)5-11-7-18(23-2)17(22)9-13(11)15/h7-10,15-16,22H,5-6H2,1-4H3/t15-,16-/m0/s1
InChIKey: ZQCGNPNWSMJDEF-HOTGVXAUSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Cryptocarya laevigata | Cryptocarya | Lauraceae | Laurales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 341.4070000000001
TPSA？: 51.16
MolLogP？: 3.2444000000000024
Number of H-Donors: 1
Number of H-Acceptors: 5
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | A549 | IC50 | 40000.0 | nM | 10.1021/acs.jnatprod.6b01153 |
| Homo sapiens | KB | IC50 | 40000.0 | nM | 10.1021/acs.jnatprod.6b01153 |
| Homo sapiens | MCF7 | IC50 | 40000.0 | nM | 10.1021/acs.jnatprod.6b01153 |
| Homo sapiens | MDA-MB-231 | IC50 | 40000.0 | nM | 10.1021/acs.jnatprod.6b01153 |
| None | Unchecked | IC50 | 40000.0 | nM | 10.1021/acs.jnatprod.6b01153 |