Molecule

(-)-Isocaryachine

AlkaPlorer ID: AK063027

Synonym: '', '(+)-Isocaryachine'

IUPAC Name: (1S,12S)-15-methoxy-20-methyl-5,7-dioxa-20-azapentacyclo[10.7.1.02,10.04,8.013,18]icosa-2,4(8),9,13,15,17-hexaen-16-ol

Structure

SMILES: COC1=C(O)C=C2C[C@H]3C4=C(C=C5OCOC5=C4)C[C@@H](C2=C1)N3C

InChI: InChI=1S/C19H19NO4/c1-20-14-3-10-5-16(21)17(22-2)7-12(10)15(20)4-11-6-18-19(8-13(11)14)24-9-23-18/h5-8,14-15,21H,3-4,9H2,1-2H3/t14-,15-/m0/s1

InChIKey: SMMBTQGVTOTRAA-GJZGRUSLSA-N

Reference

Alkaloids from the Leaves of Cryptocarya chinensis HEMSL.

PubChem CID: 11823545

LOTUS: LTS0195596

SuperNatural Ⅲ: SN0349566-02

NPASS: NPC185467

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Alpinia pricei	Alpinia	Zingiberaceae	Zingiberales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Chenopodiastrum murale	Chenopodiastrum	Chenopodiaceae	Caryophyllales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Veretillum cynomorium	Veretillum	Veretillidae	Scleralcyonacea	Anthozoa	Cnidaria	Metazoa	Eukaryota
Cyttaria johowii	Cyttaria	Cyttariaceae	Cyttariales	Leotiomycetes	Ascomycota	Fungi	Eukaryota
Ficus septica	Ficus	Moraceae	Rosales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Nalanthamala diospyri	Nalanthamala	Nectriaceae	Hypocreales	Sordariomycetes	Ascomycota	Fungi	Eukaryota
Coprosma foetidissima	Coprosma	Rubiaceae	Gentianales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Sphaerechinus granularis	Sphaerechinus	Toxopneustidae	Temnopleuroida	Echinoidea	Echinodermata	Metazoa	Eukaryota
Marrubium parviflorum	Marrubium	Lamiaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Beilschmiedia kunstleri	Beilschmiedia	Lauraceae	Laurales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Davidsonia pruriens	Davidsonia	Cunoniaceae	Oxalidales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Trifolium diffusum	Trifolium	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Hypocrella bambusae	Hypocrella	Clavicipitaceae	Hypocreales	Sordariomycetes	Ascomycota	Fungi	Eukaryota
Chenopodium quinoa	Chenopodium	Chenopodiaceae	Caryophyllales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Scleropyrum wallichianum	Scleropyrum	Cervantesiaceae	Santalales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Lippia graveolens	Lippia	Verbenaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Psathyrotes ramosissima	Psathyrotes	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Geranium collinum	Geranium	Geraniaceae	Geraniales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Girgensohnia oppositiflora	Girgensohnia	Chenopodiaceae	Caryophyllales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Citrus medica	Citrus	Rutaceae	Sapindales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Aralia hispida	Aralia	Araliaceae	Apiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Cryptocarya laevigata	Cryptocarya	Lauraceae	Laurales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Youngia japonica	Youngia	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Ferulago sylvatica	Ferulago	Apiaceae	Apiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Crinum stuhlmannii	Crinum	Amaryllidaceae	Asparagales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Parthenium confertum	Parthenium	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Metrodorea flavida	Metrodorea	Rutaceae	Sapindales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Gordonia terrae	Gordonia	Gordoniaceae	Mycobacteriales	Actinomycetes	Actinomycetota	None	Bacteria
Streptomyces graminofaciens	Streptomyces	Streptomycetaceae	Kitasatosporales	Actinomycetes	Actinomycetota	None	Bacteria
Cryptocarya chinensis	Cryptocarya	Lauraceae	Laurales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Veronica stricta	Veronica	Plantaginaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Baeckea frutescens	Baeckea	Myrtaceae	Myrtales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Seiridium cardinale	Seiridium	Sporocadaceae	Xylariales	Sordariomycetes	Ascomycota	Fungi	Eukaryota
Isodon eriocalyx	Isodon	Lamiaceae	Lamiales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Lychnophora pinaster	Lychnophora	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Metadina trichotoma	Metadina	Rubiaceae	Gentianales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Harpullia cupanioides	Harpullia	Sapindaceae	Sapindales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Palaquium leiocarpum	Palaquium	Sapotaceae	Ericales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Microglossa pyrifolia	Microglossa	Asteraceae	Asterales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Curcuma wenyujin	Curcuma	Zingiberaceae	Zingiberales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Paeonia officinalis	Paeonia	Paeoniaceae	Saxifragales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 325.36400000000003

TPSA？: 51.16

MolLogP？: 2.9559000000000006

Number of H-Donors: 1

Number of H-Acceptors: 5

RingCount: 5

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Homo sapiens	A549	IC50	3981.0	nM	10.1021/acs.jnatprod.6b01153
Homo sapiens	KB	IC50	5488.0	nM	10.1021/acs.jnatprod.6b01153
Homo sapiens	MCF7	IC50	7421.0	nM	10.1021/acs.jnatprod.6b01153
Homo sapiens	MDA-MB-231	IC50	5707.0	nM	10.1021/acs.jnatprod.6b01153
None	Unchecked	IC50	5907.0	nM	10.1021/acs.jnatprod.6b01153