Molecule

Oseltamivir

AlkaPlorer ID: AK063427

Synonym: None

IUPAC Name: ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate

Structure

SMILES: CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](N=C(C)O)[C@@H](N)C1

InChI: InChI=1S/C16H28N2O4/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19/h9,12-15H,5-8,17H2,1-4H3,(H,18,19)/t13-,14+,15+/m0/s1

InChIKey: VSZGPKBBMSAYNT-RRFJBIMHSA-N

Reference

Alkaloids from the Root of <i>Isatis indigotica</i>

PubChem CID: 65028

CAS: 196618-13-0

LOTUS: LTS0229483

NPASS: NPC469895

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Glycyrrhiza uralensis	Glycyrrhiza	Fabaceae	Fabales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota

Properties Information

Molecule Weight: 312.41

TPSA？: 94.14

MolLogP？: 2.1257

Number of H-Donors: 2

Number of H-Acceptors: 5

RingCount: 1

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Canis lupus familiaris	MDCK	Activity	7.0	%	10.1021/np1002753
Canis lupus familiaris	MDCK	Activity	98.5	%	10.1039/C6MD00292G
Canis lupus familiaris	MDCK	Activity	100.0	ug ml-1	10.1016/j.ejmech.2010.07.058
Canis lupus familiaris	MDCK	AUC	24.0	ng.hr.mL-1	10.1128/aac.00167-09
Canis lupus familiaris	MDCK	CC20	320.51	uM	10.1016/j.ejmech.2021.113738
Canis lupus familiaris	MDCK	CC50	100.0	ug.mL-1	10.1016/j.ejmech.2010.07.058
Canis lupus familiaris	MDCK	CC50	100.0	ug.mL-1	10.1016/j.ejmech.2010.09.065
Canis lupus familiaris	MDCK	CC50	300.0	ug.mL-1	10.1016/j.bmc.2016.09.064
Canis lupus familiaris	MDCK	CC50	1000.0	nM	10.1016/j.bmc.2017.03.052
Canis lupus familiaris	MDCK	CC50	35170.0	nM	10.1016/j.ejmech.2013.05.044
Canis lupus familiaris	MDCK	CC50	80000.0	nM	10.1021/ml500236n
Canis lupus familiaris	MDCK	CC50	100000.0	nM	10.1007/s00044-012-0184-x
Canis lupus familiaris	MDCK	CC50	100000.0	nM	10.1016/j.bmc.2008.08.041
Canis lupus familiaris	MDCK	CC50	100000.0	nM	10.1016/j.ejmech.2012.03.007
Canis lupus familiaris	MDCK	CC50	100000.0	nM	10.1016/j.ejmech.2013.01.015
Canis lupus familiaris	MDCK	CC50	100000.0	nM	10.1016/j.ejmech.2015.02.028
Canis lupus familiaris	MDCK	CC50	100000.0	nM	10.1016/j.ejmech.2015.09.037
Canis lupus familiaris	MDCK	CC50	100000.0	nM	10.1021/acs.jmedchem.8b00890
Canis lupus familiaris	MDCK	CC50	100000.0	nM	10.1021/acsmedchemlett.7b00458
Canis lupus familiaris	MDCK	CC50	100000.0	nM	10.1021/jm801470b
Canis lupus familiaris	MDCK	CC50	160300.0	nM	10.1039/C6MD00657D
Canis lupus familiaris	MDCK	CC50	200000.0	nM	10.1016/j.ejmech.2015.02.006
Canis lupus familiaris	MDCK	CC50	200000.0	nM	10.1016/j.ejmech.2018.12.006
Canis lupus familiaris	MDCK	CC50	200000.0	nM	10.1016/j.ejmech.2021.113591
Canis lupus familiaris	MDCK	CC50	250000.0	nM	10.1021/acs.jmedchem.5b01935
Canis lupus familiaris	MDCK	CC50	300000.0	nM	10.1016/j.bmc.2009.08.036
Canis lupus familiaris	MDCK	CC50	321000.0	nM	10.1016/j.bmc.2015.11.028
Canis lupus familiaris	MDCK	CC50	500000.0	nM	10.1016/j.bmcl.2017.11.003
Canis lupus familiaris	MDCK	CC50	500000.0	nM	10.1039/C6MD00292G
Canis lupus familiaris	MDCK	CC50	640000.0	nM	10.1021/acs.jmedchem.0c00232
Canis lupus familiaris	MDCK	CC50	800000.0	nM	10.1016/j.ejmech.2021.113762
Canis lupus familiaris	MDCK	CC50	3521000.0	nM	10.1128/aac.01051-06
Canis lupus familiaris	MDCK	CC50	7865400.0	nM	10.1016/j.ejmech.2021.113738
Canis lupus familiaris	MDCK	CC50	nan	None	10.1021/acs.jmedchem.6b01115
Canis lupus familiaris	MDCK	CC50	nan	None	10.1021/acs.jnatprod.7b00677
Canis lupus familiaris	MDCK	CC50	nan	None	10.1021/np400817j
Canis lupus familiaris	MDCK	EC50	2240.0	nM	10.1021/np1002753
Canis lupus familiaris	MDCK	MCC	100.0	ug.mL-1	10.1016/j.ejmech.2010.09.065
Canis lupus familiaris	MDCK	MCC	100000.0	nM	10.1007/s00044-012-0184-x
Canis lupus familiaris	MDCK	MCC	100000.0	nM	10.1016/j.bmc.2008.08.041
Canis lupus familiaris	MDCK	MCC	100000.0	nM	10.1016/j.bmc.2011.04.016
Canis lupus familiaris	MDCK	MCC	100000.0	nM	10.1016/j.bmc.2018.05.034
Canis lupus familiaris	MDCK	MCC	100000.0	nM	10.1016/j.ejmech.2012.03.007
Canis lupus familiaris	MDCK	MCC	100000.0	nM	10.1016/j.ejmech.2013.05.046
Canis lupus familiaris	MDCK	MCC	100000.0	nM	10.1016/j.ejmech.2013.06.036
Canis lupus familiaris	MDCK	MCC	100000.0	nM	10.1016/j.ejmech.2015.02.028
Canis lupus familiaris	MDCK	MCC	100000.0	nM	10.1021/jm801470b
Canis lupus familiaris	MDCK	MCC	100000.0	nM	10.1021/ml300279b
Canis lupus familiaris	MDCK	MNCC	243.7	uM	10.1016/j.ejmech.2021.113161
Canis lupus familiaris	MDCK	T1/2	8.0	hr	10.1128/aac.00167-09
Canis lupus familiaris	MDCK	TC50	243.7	uM	10.1016/j.ejmech.2021.113161
Canis lupus familiaris	MDCK	TC50	1260.0	ug ml-1	10.1016/j.bmcl.2016.06.011
Canis lupus familiaris	MDCK	TC50	1260.0	ug ml-1	10.1016/j.ejmech.2014.02.029
Canis lupus familiaris	MDCK	TC50	1260.0	uM	10.1021/acs.jnatprod.7b01074
Canis lupus familiaris	MDCK	TC50	1260.0	umol/L	10.1021/acs.jnatprod.6b00585
Canis lupus familiaris	MDCK	TC50	1408.3	uM	10.1016/j.bmcl.2019.08.009
Canis lupus familiaris	MDCK	TC50	3070.18	uM	10.1021/acs.jnatprod.5b00325
Canis lupus familiaris	MDCK	TC50	3070.2	uM	10.1016/j.ejmech.2012.07.008
Canis lupus familiaris	MDCK	TC50	3073.0	uM	10.1016/j.ejmech.2020.112577
Canis lupus familiaris	MDCK	TC50	3120.0	uM	10.1021/np500951s
Chlorocebus sabaeus	Vero	MCC	nan	None	10.1016/j.bmc.2011.04.016
Chlorocebus sabaeus	Vero	MNCC	1.6	ug ml-1	10.1007/s00044-010-9338-x
Chlorocebus sabaeus	Vero	MNTD	1.6	ug ml-1	10.1016/j.ejmech.2010.05.069
Chlorocebus sabaeus	Vero C1008	CC50	100000.0	nM	10.1016/j.ejmech.2020.112687
Clostridium perfringens	Sialidase	IC50	61100.0	nM	10.1016/j.bmcl.2017.11.003
Coxsackievirus B4	Coxsackievirus B4	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Coxsackievirus B4	Coxsackievirus B4	EC50	nan	None	10.1016/j.bmc.2011.04.016
Felid alphaherpesvirus 1	Felid alphaherpesvirus 1	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Feline coronavirus	Feline coronavirus	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Feline coronavirus	Feline coronavirus	EC50	nan	None	10.1016/j.bmc.2011.04.016
H2N2 subtype	H2N2 subtype	IC50	1450.0	nM	10.1016/j.bmc.2008.11.075
H3N2 subtype	H3N2 subtype	EC50	800.0	nM	10.1021/jm900950d
H3N2 subtype	H3N2 subtype	EC50	990.0	nM	10.1021/acs.jmedchem.8b00042
H3N2 subtype	H3N2 subtype	EC50	1100.0	nM	10.1021/jm900950d
H3N2 subtype	H3N2 subtype	EC50	29000.0	nM	10.1021/ml300279b
H5N1 subtype	H5N1 subtype	EC50	5970.0	nM	10.1016/j.ejmech.2021.113762
H5N1 subtype	H5N1 subtype	IC50	34000.0	nM	10.1016/j.bmc.2008.11.075
Homo sapiens	A549	CC50	200000.0	nM	10.1016/j.bmcl.2019.07.028
Homo sapiens	Acetylcholinesterase	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Acyl coenzyme A:cholesterol acyltransferase	Km	177000.0	nM	10.1016/j.bmc.2009.10.052
Homo sapiens	Acyl coenzyme A:cholesterol acyltransferase	pKm	3.75	None	10.1016/j.bmc.2009.10.052
Homo sapiens	Adenosine A3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-1a adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Alpha-2a adrenergic receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Androgen Receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Bile salt export pump	AC50	300000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	CCRF-CEM	CC50	nan	None	10.1016/j.bmc.2011.04.016
Homo sapiens	Cyclooxygenase-1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Cytochrome P450 2C9	FC	1.0	None	10.1016/j.bmcl.2016.06.088
Homo sapiens	Cytochrome P450 2D6	FC	1.0	None	10.1016/j.bmcl.2016.06.088
Homo sapiens	Cytochrome P450 3A4	FC	1.0	None	10.1016/j.bmcl.2016.06.088
Homo sapiens	Dopamine D1 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine D3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Dopamine transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Estrogen receptor alpha	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	HeLa	CC50	nan	None	10.1016/j.bmc.2011.04.016
Homo sapiens	HERG	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histamine H3 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Histone deacetylase 6	Inhibition	-14.7	%	10.6019/CHEMBL4808148
Homo sapiens	Histone deacetylase 6	Inhibition	-7.83	%	10.6019/CHEMBL4808148
Homo sapiens	Homo sapiens	AUC	238.0	ng.hr.mL-1	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	AUC	244.0	ng.hr.mL-1	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	AUC	280.0	ng.hr.mL-1	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	AUC	287.0	ng.hr.mL-1	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	CL	20.4	L/hr	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	CL	23.1	L/hr	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	CL/F	9.54	L/min	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	CL/F	13.0	L/min	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	Cmax	323.29	nM	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	Cmax	396.91	nM	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	DILI_Concern	nan	None	10.1016/j.drudis.2016.02.015
Homo sapiens	Homo sapiens	DILI_severity_class	3.0	None	10.1016/j.drudis.2016.02.015
Homo sapiens	Homo sapiens	F	75.0	%	10.1016/j.bmc.2007.08.060
Homo sapiens	Homo sapiens	F	80.0	%	10.1016/j.ejmech.2016.10.061
Homo sapiens	Homo sapiens	T1/2	1.61	hr	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	T1/2	2.15	hr	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	Tmax	0.806	hr	10.1124/dmd.112.044990
Homo sapiens	Homo sapiens	Tmax	2.06	hr	10.1124/dmd.112.044990
Homo sapiens	Monoamine oxidase A	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Mu opioid receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M1	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Muscarinic acetylcholine receptor M2	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Norepinephrine transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Oligopeptide transporter small intestine isoform	Inhibition	nan	%	10.1124/dmd.112.044990
Homo sapiens	P-glycoprotein 1	IC50	1300000.0	nM	10.1128/aac.01541-08
Homo sapiens	P-glycoprotein 1	Km	4200000.0	nM	10.1128/aac.01541-08
Homo sapiens	P-glycoprotein 1	permeability	38.9	nm/s	10.1128/aac.01541-08
Homo sapiens	P-glycoprotein 1	Vmax	8.9	pmol/s	10.1128/aac.01541-08
Homo sapiens	Phosphodiesterase 3A	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Phosphodiesterase 4A	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Progesterone receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 1a (5-HT1a) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin 2b (5-HT2b) receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Serotonin transporter	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Sialidase 1	IC50	500000.0	nM	10.1016/j.bmc.2018.05.035
Homo sapiens	Sialidase 1	IC50	500000.0	nM	10.1021/acs.jmedchem.1c01612
Homo sapiens	Sialidase 1	IC50	10000000.0	nM	10.1128/aac.00344-08
Homo sapiens	Sialidase 1	Ki	nan	None	10.1016/j.bmc.2018.05.035
Homo sapiens	Sialidase 2	Activity	nan	None	10.1021/jm100078r
Homo sapiens	Sialidase 2	IC50	500000.0	nM	10.1016/j.bmc.2018.05.035
Homo sapiens	Sialidase 2	IC50	500000.0	nM	10.1021/acs.jmedchem.1c01612
Homo sapiens	Sialidase 2	IC50	6000000.0	nM	10.1128/aac.00344-08
Homo sapiens	Sialidase 2	Ki	nan	None	10.1016/j.bmc.2018.05.035
Homo sapiens	Sialidase 2	Ki	nan	None	10.1021/jm100078r
Homo sapiens	Sialidase 3	IC50	500000.0	nM	10.1016/j.bmc.2018.05.035
Homo sapiens	Sialidase 3	IC50	500000.0	nM	10.1021/acs.jmedchem.1c01612
Homo sapiens	Sialidase 3	IC50	10000000.0	nM	10.1016/j.bmcl.2010.09.111
Homo sapiens	Sialidase 3	IC50	10000000.0	nM	10.1128/aac.00344-08
Homo sapiens	Sialidase 3	Inhibition	nan	%	10.1128/aac.00344-08
Homo sapiens	Sialidase 3	Ki	nan	None	10.1016/j.bmc.2018.05.035
Homo sapiens	Sialidase 4	IC50	500000.0	nM	10.1016/j.bmc.2018.05.035
Homo sapiens	Sialidase 4	IC50	500000.0	nM	10.1021/acs.jmedchem.1c01612
Homo sapiens	Sialidase 4	IC50	10000000.0	nM	10.1128/aac.00344-08
Homo sapiens	Sialidase 4	Ki	nan	None	10.1016/j.bmc.2018.05.035
Homo sapiens	Solute carrier family 15 member 2	Drug uptake	nan	None	10.1124/dmd.112.044990
Homo sapiens	Thrombin	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Thromboxane A2 receptor	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Homo sapiens	Vascular endothelial growth factor receptor 2	AC50	30000.0	nM	10.1038/s41467-023-40064-9
Human alphaherpesvirus 1	Human alphaherpesvirus 1	Activity	nan	None	10.1007/s00044-010-9338-x
Human alphaherpesvirus 1	Human alphaherpesvirus 1	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Human alphaherpesvirus 2	Human alphaherpesvirus 2	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Human alphaherpesvirus 3	Human alphaherpesvirus 3	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Human betaherpesvirus 5	Human betaherpesvirus 5	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Human immunodeficiency virus 1	Human immunodeficiency virus 1	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Human immunodeficiency virus 1	Human immunodeficiency virus 1	EC50	nan	None	10.1016/j.bmc.2011.04.016
Human immunodeficiency virus 2	Human immunodeficiency virus 2	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Human immunodeficiency virus 2	Human immunodeficiency virus 2	EC50	nan	None	10.1016/j.bmc.2011.04.016
Human respirovirus 3	Human respirovirus 3	Activity	0.012	ug ml-1	10.1007/s00044-010-9338-x
Human respirovirus 3	Human respirovirus 3	Activity	1.6	ug ml-1	10.1007/s00044-010-9338-x
Human respirovirus 3	Human respirovirus 3	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Human respirovirus 3	Human respirovirus 3	EC50	nan	None	10.1016/j.bmc.2011.04.016
Human respirovirus 3	Human respirovirus 3	TCID50	0.012	ug ml-1	10.1016/j.ejmech.2010.05.069
Influenza A virus	Influenza A virus	Activity	-24.4	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	-22.0	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	-20.3	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	-18.2	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	-17.6	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	-11.2	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	-10.7	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	-10.6	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	-7.6	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	-7.0	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	-2.1	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	-0.2	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	0.0	%	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	Activity	0.624	U	10.1128/aac.00167-09
Influenza A virus	Influenza A virus	Activity	1.2	%	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	Activity	1.2	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Activity	2.3	%	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	Activity	3.4	%	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	Activity	3.9	%	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	Activity	5.0	%	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	Activity	5.7	%	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	Activity	6.0	%	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	Activity	7.3	day	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	Activity	8.8	%	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	Activity	11.0	%	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	Activity	13.4	%	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	Activity	17.9	%	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	Activity	20.1	%	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	Activity	20.4	%	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	Activity	21.0	day	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	Activity	21.5	%	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	Activity	22.1	%	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	Activity	23.7	%	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	Activity	38.0	%	10.1021/acs.jmedchem.9b01091
Influenza A virus	Influenza A virus	Activity	75.0	%	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	Activity	100.0	%	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	Activity	nan	None	10.1016/j.bmc.2009.08.036
Influenza A virus	Influenza A virus	Activity	nan	None	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Influenza A virus	Influenza A virus	Activity	nan	None	10.1016/j.ejmech.2017.12.072
Influenza A virus	Influenza A virus	Activity	nan	None	10.1016/j.ejmech.2018.05.030
Influenza A virus	Influenza A virus	Activity	nan	None	10.1021/acs.jmedchem.0c00067
Influenza A virus	Influenza A virus	Activity	nan	None	10.1021/acs.jmedchem.0c00312
Influenza A virus	Influenza A virus	Activity	nan	None	10.1021/acs.jmedchem.2c01329
Influenza A virus	Influenza A virus	Activity	nan	None	10.1021/acs.jmedchem.6b00326
Influenza A virus	Influenza A virus	Activity	nan	None	10.1021/acs.jmedchem.8b00557
Influenza A virus	Influenza A virus	Activity	nan	None	10.1021/acsmedchemlett.6b00486
Influenza A virus	Influenza A virus	Activity	nan	None	10.1021/jm800455g
Influenza A virus	Influenza A virus	Activity	nan	None	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	Activity	nan	None	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	EC50	0.000726	ug.mL-1	10.1128/aac.00167-09
Influenza A virus	Influenza A virus	EC50	0.01023	ug.mL-1	10.1128/aac.00167-09
Influenza A virus	Influenza A virus	EC50	0.1	ug.mL-1	10.1016/j.ejmech.2010.07.058
Influenza A virus	Influenza A virus	EC50	0.2	ug.mL-1	10.1016/j.ejmech.2010.07.058
Influenza A virus	Influenza A virus	EC50	0.3	ug.mL-1	10.1016/j.bmc.2016.09.064
Influenza A virus	Influenza A virus	EC50	1.0	nM	10.1021/acsmedchemlett.7b00458
Influenza A virus	Influenza A virus	EC50	1.4	nM	10.1128/aac.01051-06
Influenza A virus	Influenza A virus	EC50	2.0	nM	10.1021/acsmedchemlett.7b00458
Influenza A virus	Influenza A virus	EC50	3.8	ug.mL-1	10.1016/j.ejmech.2010.07.058
Influenza A virus	Influenza A virus	EC50	4.0	ug.mL-1	10.1016/j.ejmech.2010.07.058
Influenza A virus	Influenza A virus	EC50	6.9	ug.mL-1	10.1016/j.ejmech.2010.09.065
Influenza A virus	Influenza A virus	EC50	8.26	nM	10.1016/j.bmc.2017.03.052
Influenza A virus	Influenza A virus	EC50	9.0	ug.mL-1	10.1016/j.ejmech.2010.09.065
Influenza A virus	Influenza A virus	EC50	10.0	nM	10.1016/j.ejmech.2013.01.015
Influenza A virus	Influenza A virus	EC50	10.0	nM	10.1021/acs.jmedchem.8b00890
Influenza A virus	Influenza A virus	EC50	12.0	ug.mL-1	10.1016/j.ejmech.2010.09.065
Influenza A virus	Influenza A virus	EC50	15.0	nM	10.1021/acs.jmedchem.5b01935
Influenza A virus	Influenza A virus	EC50	20.0	nM	10.1016/j.ejmech.2013.05.046
Influenza A virus	Influenza A virus	EC50	20.0	nM	10.1021/acsmedchemlett.7b00458
Influenza A virus	Influenza A virus	EC50	22.0	nM	10.1021/acs.jmedchem.2c01329
Influenza A virus	Influenza A virus	EC50	28.0	ug.mL-1	10.1016/j.ejmech.2010.09.065
Influenza A virus	Influenza A virus	EC50	30.0	nM	10.1016/j.bmc.2015.11.028
Influenza A virus	Influenza A virus	EC50	30.0	nM	10.1021/acsmedchemlett.7b00458
Influenza A virus	Influenza A virus	EC50	32.0	nM	10.1128/aac.01051-06
Influenza A virus	Influenza A virus	EC50	50.0	nM	10.1016/j.ejmech.2013.01.015
Influenza A virus	Influenza A virus	EC50	90.0	nM	10.1016/j.ejmech.2013.05.046
Influenza A virus	Influenza A virus	EC50	110.0	nM	10.1016/j.ejmech.2013.05.044
Influenza A virus	Influenza A virus	EC50	110.0	nM	10.1021/ml300279b
Influenza A virus	Influenza A virus	EC50	130.0	nM	10.1021/acs.jmedchem.8b00042
Influenza A virus	Influenza A virus	EC50	140.0	nM	10.1128/aac.01051-06
Influenza A virus	Influenza A virus	EC50	151.7	nM	10.1016/j.bmc.2017.03.052
Influenza A virus	Influenza A virus	EC50	200.0	nM	10.1016/j.bmc.2018.05.034
Influenza A virus	Influenza A virus	EC50	240.0	nM	10.1016/j.bmc.2013.10.020
Influenza A virus	Influenza A virus	EC50	280.0	nM	10.1128/aac.01051-06
Influenza A virus	Influenza A virus	EC50	400.0	nM	10.1021/acs.jmedchem.8b00042
Influenza A virus	Influenza A virus	EC50	500.0	nM	10.1016/j.bmcl.2013.04.033
Influenza A virus	Influenza A virus	EC50	600.0	nM	10.1021/acs.jnatprod.7b00677
Influenza A virus	Influenza A virus	EC50	820.0	nM	10.1016/j.ejmech.2015.09.037
Influenza A virus	Influenza A virus	EC50	1480.0	nM	10.1021/acs.jmedchem.8b00890
Influenza A virus	Influenza A virus	EC50	1500.0	nM	10.1016/j.bmc.2018.05.034
Influenza A virus	Influenza A virus	EC50	1500.0	nM	10.1021/ml300279b
Influenza A virus	Influenza A virus	EC50	1900.0	nM	10.1016/j.ejmech.2013.06.036
Influenza A virus	Influenza A virus	EC50	2000.0	nM	10.1016/j.ejmech.2015.02.028
Influenza A virus	Influenza A virus	EC50	2000.0	nM	10.1021/jm900950d
Influenza A virus	Influenza A virus	EC50	2140.0	nM	10.1021/acs.jmedchem.0c00232
Influenza A virus	Influenza A virus	EC50	2300.0	nM	10.1021/acs.jmedchem.8b00042
Influenza A virus	Influenza A virus	EC50	2670.0	nM	10.1021/acs.jmedchem.8b00042
Influenza A virus	Influenza A virus	EC50	2900.0	nM	10.1016/j.ejmech.2015.02.028
Influenza A virus	Influenza A virus	EC50	3000.0	nM	10.1021/ml300279b
Influenza A virus	Influenza A virus	EC50	3060.0	nM	10.1016/j.ejmech.2013.05.044
Influenza A virus	Influenza A virus	EC50	4000.0	nM	10.1016/j.ejmech.2012.03.007
Influenza A virus	Influenza A virus	EC50	5400.0	nM	10.1016/j.ejmech.2013.06.036
Influenza A virus	Influenza A virus	EC50	5600.0	nM	10.1016/j.ejmech.2012.03.007
Influenza A virus	Influenza A virus	EC50	6250.0	nM	10.1016/j.bmc.2009.08.036
Influenza A virus	Influenza A virus	EC50	8300.0	nM	10.1016/j.bmc.2009.08.036
Influenza A virus	Influenza A virus	EC50	8600.0	nM	10.1021/jm900950d
Influenza A virus	Influenza A virus	EC50	9000.0	nM	10.1016/j.ejmech.2012.03.007
Influenza A virus	Influenza A virus	EC50	9700.0	nM	10.1016/j.ejmech.2012.03.007
Influenza A virus	Influenza A virus	EC50	9750.0	nM	10.1016/j.ejmech.2015.09.037
Influenza A virus	Influenza A virus	EC50	10000.0	nM	10.1021/acs.jmedchem.2c01329
Influenza A virus	Influenza A virus	EC50	10000.0	nM	10.1021/acs.jmedchem.8b00042
Influenza A virus	Influenza A virus	EC50	10000.0	nM	10.1021/jm5007275
Influenza A virus	Influenza A virus	EC50	11000.0	nM	10.1016/j.bmcl.2010.03.080
Influenza A virus	Influenza A virus	EC50	12000.0	nM	10.1016/j.bmc.2011.04.016
Influenza A virus	Influenza A virus	EC50	12000.0	nM	10.1016/j.bmcl.2010.03.080
Influenza A virus	Influenza A virus	EC50	16000.0	nM	10.1021/ml300279b
Influenza A virus	Influenza A virus	EC50	18990.0	nM	10.1016/j.ejmech.2013.05.044
Influenza A virus	Influenza A virus	EC50	20000.0	nM	10.1021/ml500533x
Influenza A virus	Influenza A virus	EC50	21000.0	nM	10.1021/ml300279b
Influenza A virus	Influenza A virus	EC50	21700.0	nM	10.1021/acs.jmedchem.8b00890
Influenza A virus	Influenza A virus	EC50	32000.0	nM	10.1016/j.bmcl.2010.03.080
Influenza A virus	Influenza A virus	EC50	38000.0	nM	10.1016/j.bmcl.2010.03.080
Influenza A virus	Influenza A virus	EC50	39100.0	nM	10.1007/s00044-012-0184-x
Influenza A virus	Influenza A virus	EC50	80000.0	nM	10.1021/ml500236n
Influenza A virus	Influenza A virus	EC50	80100.0	nM	10.1016/j.ejmech.2021.113738
Influenza A virus	Influenza A virus	EC50	90000.0	nM	10.1016/j.bmc.2011.04.016
Influenza A virus	Influenza A virus	EC50	200000.0	nM	10.1016/j.ejmech.2015.09.037
Influenza A virus	Influenza A virus	EC50	243700.0	nM	10.1016/j.ejmech.2021.113161
Influenza A virus	Influenza A virus	EC50	800000.0	nM	10.1021/jm801470b
Influenza A virus	Influenza A virus	EC50	900000.0	nM	10.1021/jm801470b
Influenza A virus	Influenza A virus	EC50	nan	None	10.1021/acs.jmedchem.2c01329
Influenza A virus	Influenza A virus	EC90	0.007	uM	10.1128/aac.01051-06
Influenza A virus	Influenza A virus	EC90	0.07	uM	10.1128/aac.01051-06
Influenza A virus	Influenza A virus	EC90	0.67	uM	10.1128/aac.01051-06
Influenza A virus	Influenza A virus	EC90	0.92	uM	10.1128/aac.01051-06
Influenza A virus	Influenza A virus	FC	260.0	None	10.1021/acs.jmedchem.8b00557
Influenza A virus	Influenza A virus	IC50	0.16	nM	10.1128/aac.01608-09
Influenza A virus	Influenza A virus	IC50	0.2	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	0.25	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	0.3	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	0.34	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	0.4	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	0.44	nM	10.1128/aac.01608-09
Influenza A virus	Influenza A virus	IC50	0.49	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	0.51	nM	10.1021/acs.jmedchem.8b00890
Influenza A virus	Influenza A virus	IC50	0.54	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	0.7	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	0.8	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	0.85	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	1.0	nM	10.1016/j.bmcl.2013.11.077
Influenza A virus	Influenza A virus	IC50	1.0	ug.mL-1	10.1016/j.ejmech.2014.02.029
Influenza A virus	Influenza A virus	IC50	1.08	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	1.5	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	1.59	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	1.71	nM	10.1021/acs.jmedchem.8b00890
Influenza A virus	Influenza A virus	IC50	1.84	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	2.27	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	2.4	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	2.81	ug.mL-1	10.1016/j.ejmech.2014.02.029
Influenza A virus	Influenza A virus	IC50	3.1	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	3.19	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	IC50	3.41	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	3.64	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	3.79	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	3.9	ug.mL-1	10.1016/j.bmcl.2016.06.011
Influenza A virus	Influenza A virus	IC50	4.0	nM	10.1021/np400817j
Influenza A virus	Influenza A virus	IC50	4.12	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	IC50	4.5	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	5.3	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	5.49	nM	10.1128/aac.01608-09
Influenza A virus	Influenza A virus	IC50	6.05	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	IC50	6.13	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	IC50	6.4	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	7.03	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	7.39	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	IC50	8.06	nM	10.1128/aac.01608-09
Influenza A virus	Influenza A virus	IC50	9.18	nM	10.1128/aac.01608-09
Influenza A virus	Influenza A virus	IC50	11.9	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	12.14	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	IC50	12.75	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	IC50	15.0	nM	10.1016/j.bmcl.2015.08.034
Influenza A virus	Influenza A virus	IC50	16.9	nM	10.1016/j.ejmech.2020.112790
Influenza A virus	Influenza A virus	IC50	16.9	nM	10.1021/acs.jnatprod.5b00650
Influenza A virus	Influenza A virus	IC50	18.5	nM	10.1016/j.ejmech.2020.112790
Influenza A virus	Influenza A virus	IC50	25.0	nM	10.1016/j.bmcl.2015.08.034
Influenza A virus	Influenza A virus	IC50	25.3	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	27.8	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	30.0	nM	10.1021/np400817j
Influenza A virus	Influenza A virus	IC50	31.0	nM	10.1021/acs.jmedchem.9b01091
Influenza A virus	Influenza A virus	IC50	33.25	nM	10.1128/aac.01608-09
Influenza A virus	Influenza A virus	IC50	34.0	nM	10.1016/j.ejmech.2020.112790
Influenza A virus	Influenza A virus	IC50	64.0	nM	10.1021/acs.jnatprod.7b00774
Influenza A virus	Influenza A virus	IC50	69.82	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	IC50	71.53	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	IC50	75.29	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	78.12	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	84.26	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	IC50	93.92	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	94.4	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	95.43	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	99.57	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	100.0	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	IC50	145.2	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	154.0	nM	10.1128/aac.01608-09
Influenza A virus	Influenza A virus	IC50	194.1	nM	10.1021/jm901440f
Influenza A virus	Influenza A virus	IC50	200.0	nM	10.1039/C6MD00657D
Influenza A virus	Influenza A virus	IC50	245.5	nM	10.1128/aac.01608-09
Influenza A virus	Influenza A virus	IC50	300.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	430.59	nM	10.1128/aac.01608-09
Influenza A virus	Influenza A virus	IC50	498.9	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	500.0	ug.mL-1	10.1016/j.ejmech.2014.02.029
Influenza A virus	Influenza A virus	IC50	579.0	nM	10.1016/j.bmcl.2017.11.003
Influenza A virus	Influenza A virus	IC50	695.6	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	770.66	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	816.52	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	900.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	945.39	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	966.27	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	976.71	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	1048.21	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	1070.0	nM	10.1021/acs.jnatprod.5b00325
Influenza A virus	Influenza A virus	IC50	1097.43	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	1178.3	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	1204.9	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	1230.0	nM	10.1021/np3002833
Influenza A virus	Influenza A virus	IC50	1333.82	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	1462.51	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	1469.7	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	1502.8	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	1630.0	nM	10.1021/acs.jnatprod.7b01074
Influenza A virus	Influenza A virus	IC50	1700.0	nM	10.1021/acs.jnatprod.6b00585
Influenza A virus	Influenza A virus	IC50	2000.0	nM	10.1016/j.ejmech.2012.07.008
Influenza A virus	Influenza A virus	IC50	2050.03	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	2100.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	2207.72	nM	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	IC50	2300.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	2500.0	nM	10.1016/j.bmc.2008.11.075
Influenza A virus	Influenza A virus	IC50	3000.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	3009.1	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	3380.0	nM	10.1016/j.ejmech.2020.112577
Influenza A virus	Influenza A virus	IC50	3440.0	nM	10.1016/j.ejmech.2021.113591
Influenza A virus	Influenza A virus	IC50	4180.0	nM	10.1016/j.bmcl.2019.07.028
Influenza A virus	Influenza A virus	IC50	4250.0	nM	10.1016/j.bmcl.2019.07.028
Influenza A virus	Influenza A virus	IC50	4610.0	nM	10.1016/j.bmcl.2019.07.028
Influenza A virus	Influenza A virus	IC50	5700.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	6126.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	6200.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	10000.0	nM	10.1016/j.ejmech.2015.09.037
Influenza A virus	Influenza A virus	IC50	15600.0	nM	10.1016/j.bmcl.2019.08.009
Influenza A virus	Influenza A virus	IC50	16500.0	nM	10.1016/j.ejmech.2018.12.006
Influenza A virus	Influenza A virus	IC50	18200.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	20510.0	nM	10.1016/j.ejmech.2015.02.006
Influenza A virus	Influenza A virus	IC50	46100.0	nM	10.1021/acs.jmedchem.0c00312
Influenza A virus	Influenza A virus	IC50	46700.0	nM	10.1016/j.ejmech.2020.112790
Influenza A virus	Influenza A virus	IC50	89200.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	152800.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	177000.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	179560.0	nM	10.1016/j.ejmech.2021.113591
Influenza A virus	Influenza A virus	IC50	180300.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	191600.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	200000.0	nM	10.1016/j.ejmech.2015.02.006
Influenza A virus	Influenza A virus	IC50	1390000.0	nM	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	IC50	2436600.0	nM	10.1016/j.ejmech.2012.07.008
Influenza A virus	Influenza A virus	Inhibition	25.7	%	10.1016/j.bmc.2017.07.006
Influenza A virus	Influenza A virus	Inhibition	30.0	%	10.1021/jm5007275
Influenza A virus	Influenza A virus	Inhibition	nan	%	10.1021/acs.jmedchem.8b00890
Influenza A virus	Influenza A virus	Inhibition	nan	%	10.1128/aac.00167-09
Influenza A virus	Influenza A virus	Inhibition	nan	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Log10CCID50/g	6.1	None	10.1128/aac.01051-06
Influenza A virus	Influenza A virus	log10EID50/g	0.75	None	10.1128/aac.01312-06
Influenza A virus	Influenza A virus	PFU	5200.0	None	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	PFU	13000.0	None	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	PFU	39000.0	None	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	PFU	52000.0	None	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	PFU	190000.0	None	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	PFU	230000.0	None	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	PFU/ml	49.85	None	10.1128/aac.00167-09
Influenza A virus	Influenza A virus	Ratio IC50	1.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	3.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Ratio IC50	3.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	4.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Ratio IC50	7.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Ratio IC50	8.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Ratio IC50	32.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Ratio IC50	36.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Ratio IC50	221.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	230.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	239.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	276.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	277.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	281.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	321.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	353.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	378.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	391.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	398.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	403.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	614.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	659.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	690.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	761.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Ratio IC50	911.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Ratio IC50	920.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	971.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Ratio IC50	1925.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Ratio IC50	1943.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Ratio IC50	2412.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	2502.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Ratio IC50	2597.0	None	10.1128/aac.00581-10
Influenza A virus	Influenza A virus	Ratio IC50	8024.0	None	10.1128/aac.00334-09
Influenza A virus	Influenza A virus	Survival	0.0	%	10.1021/jm5007275
Influenza A virus	Influenza A virus	Survival	0.0	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Survival	20.0	%	10.1016/j.ejmech.2017.12.072
Influenza A virus	Influenza A virus	Survival	60.0	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Survival	70.0	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Survival	80.0	%	10.1021/acs.jmedchem.6b00326
Influenza A virus	Influenza A virus	Survival	80.0	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	Survival	100.0	%	10.1021/acs.jmedchem.0c00312
Influenza A virus	Influenza A virus	Survival	100.0	%	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	TIME	120.0	hr	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	TIME	122.4	hr	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	TIME	124.8	hr	10.1128/aac.01276-08
Influenza A virus	Influenza A virus	TIME	192.0	hr	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	TIME	232.8	hr	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	TIME	240.0	hr	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	TIME	324.0	hr	10.1128/aac.01667-08
Influenza A virus	Influenza A virus	TIME	504.0	hr	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	IC50	0.00494	ug.mL-1	10.1016/j.bmcl.2010.09.077
Influenza A virus	Neuraminidase	IC50	0.00494	ug.mL-1	10.1016/j.bmcl.2010.11.016
Influenza A virus	Neuraminidase	IC50	0.00494	ug.mL-1	10.1016/j.bmcl.2012.04.028
Influenza A virus	Neuraminidase	IC50	0.02109	ug.mL-1	10.1016/j.bmcl.2010.11.016
Influenza A virus	Neuraminidase	IC50	0.02109	ug.mL-1	10.1016/j.bmcl.2012.04.028
Influenza A virus	Neuraminidase	IC50	0.03974	ug.mL-1	10.1016/j.bmcl.2010.09.077
Influenza A virus	Neuraminidase	IC50	0.03974	ug.mL-1	10.1016/j.bmcl.2010.11.016
Influenza A virus	Neuraminidase	IC50	0.03974	ug.mL-1	10.1016/j.bmcl.2012.04.028
Influenza A virus	Neuraminidase	IC50	0.06	nM	10.1021/jm901440f
Influenza A virus	Neuraminidase	IC50	0.1	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	IC50	0.16	nM	10.1021/jm901440f
Influenza A virus	Neuraminidase	IC50	0.19	nM	10.1021/jm901440f
Influenza A virus	Neuraminidase	IC50	0.2	nM	10.1016/j.bmc.2012.01.026
Influenza A virus	Neuraminidase	IC50	0.2	nM	10.1021/jm901440f
Influenza A virus	Neuraminidase	IC50	0.2	nM	10.1021/np400817j
Influenza A virus	Neuraminidase	IC50	0.2	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	IC50	0.3	nM	10.1021/np400817j
Influenza A virus	Neuraminidase	IC50	0.3	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	IC50	0.5	nM	10.1021/np400817j
Influenza A virus	Neuraminidase	IC50	0.658	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	0.706	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	0.711	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	0.785	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	0.87	nM	10.1016/j.ejmech.2014.06.059
Influenza A virus	Neuraminidase	IC50	0.885	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	0.925	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	0.981	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.0	nM	10.1016/j.bmcl.2011.09.076
Influenza A virus	Neuraminidase	IC50	1.08	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.09	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.12	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.18	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.2	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	IC50	1.25	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.26	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.33	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.34	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.43	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.5	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	IC50	1.54	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.56	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.58	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.59	nM	10.1016/j.bmc.2009.08.036
Influenza A virus	Neuraminidase	IC50	1.6	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.7	nM	10.1016/j.bmcl.2013.04.033
Influenza A virus	Neuraminidase	IC50	1.7	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.71	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.78	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.86	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.9	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1.99	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	2.12	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	2.17	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	2.28	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	2.39	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	2.5	nM	10.1016/j.ejmech.2017.10.004
Influenza A virus	Neuraminidase	IC50	2.56	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	2.8	nM	10.1016/j.bmc.2013.10.020
Influenza A virus	Neuraminidase	IC50	2.81	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	2.94	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	3.44	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	3.65	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	3.7	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	IC50	4.9	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	IC50	4.95	nM	10.1128/aac.00344-08
Influenza A virus	Neuraminidase	IC50	5.13	ug.mL-1	10.1016/j.bmcl.2010.11.016
Influenza A virus	Neuraminidase	IC50	5.13	ug.mL-1	10.1016/j.bmcl.2012.04.028
Influenza A virus	Neuraminidase	IC50	8.0	nM	10.1016/j.bmcl.2013.11.077
Influenza A virus	Neuraminidase	IC50	10.0	nM	10.1016/j.bmcl.2013.04.033
Influenza A virus	Neuraminidase	IC50	10.0	nM	10.1016/j.bmcl.2013.11.077
Influenza A virus	Neuraminidase	IC50	10.8	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	IC50	14.8	nM	10.1016/j.ejmech.2017.10.004
Influenza A virus	Neuraminidase	IC50	16.0	nM	10.1016/j.bmc.2013.10.020
Influenza A virus	Neuraminidase	IC50	20.0	nM	10.1016/j.bmc.2011.02.019
Influenza A virus	Neuraminidase	IC50	24.9	nM	10.1016/j.bmc.2012.01.026
Influenza A virus	Neuraminidase	IC50	37.2	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	50.0	nM	10.1016/j.bmcl.2013.11.077
Influenza A virus	Neuraminidase	IC50	80.0	nM	10.1021/np400817j
Influenza A virus	Neuraminidase	IC50	136.9	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	IC50	140.0	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	150.0	nM	10.1016/j.bmc.2015.11.028
Influenza A virus	Neuraminidase	IC50	210.0	nM	10.1016/j.bmc.2015.11.028
Influenza A virus	Neuraminidase	IC50	210.0	nM	10.1016/j.ejmech.2017.10.004
Influenza A virus	Neuraminidase	IC50	755.0	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	1060.0	nM	10.1016/j.bmc.2007.01.020
Influenza A virus	Neuraminidase	IC50	3235.94	nM	10.1016/j.bmc.2007.01.020
Influenza A virus	Neuraminidase	IC50	4190.0	nM	10.1016/j.bmc.2015.11.028
Influenza A virus	Neuraminidase	IC50	6095.0	nM	10.1016/j.ejmech.2017.10.004
Influenza A virus	Neuraminidase	IC50	9600.0	nM	10.1016/j.bmc.2019.07.013
Influenza A virus	Neuraminidase	IC50	10340.0	nM	10.1021/np1002753
Influenza A virus	Neuraminidase	IC50	10400.0	nM	10.1128/aac.00333-08
Influenza A virus	Neuraminidase	IC50	12290.0	nM	10.1021/np1002753
Influenza A virus	Neuraminidase	IC50	51540.0	nM	10.1021/np1002753
Influenza A virus	Neuraminidase	IC50	79940.0	nM	10.1016/j.bmc.2015.11.028
Influenza A virus	Neuraminidase	IC50	95220.0	nM	10.1021/np1002753
Influenza A virus	Neuraminidase	IC50	800018.44	nM	10.1016/j.ejmech.2007.04.011
Influenza A virus	Neuraminidase	IC50	nan	None	10.1021/jm901440f
Influenza A virus	Neuraminidase	Inhibition	17.0	%	10.1016/j.ejmech.2014.06.059
Influenza A virus	Neuraminidase	Inhibition	51.0	%	10.1016/j.ejmech.2014.06.059
Influenza A virus	Neuraminidase	Inhibition	84.0	%	10.1016/j.ejmech.2014.06.059
Influenza A virus	Neuraminidase	Inhibition	91.0	%	10.1016/j.ejmech.2017.10.004
Influenza A virus	Neuraminidase	Inhibition	95.5	%	10.1016/j.ejmech.2017.10.004
Influenza A virus	Neuraminidase	Inhibition	97.0	%	10.1016/j.ejmech.2014.06.059
Influenza A virus	Neuraminidase	Inhibition	99.0	%	10.1016/j.ejmech.2014.06.059
Influenza A virus	Neuraminidase	Inhibition	100.0	%	10.1016/j.bmc.2015.11.028
Influenza A virus	Neuraminidase	Inhibition	nan	%	10.1021/np1002753
Influenza A virus	Neuraminidase	Ki	0.1	nM	10.1016/j.bmcl.2008.01.048
Influenza A virus	Neuraminidase	Ki	0.1	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	Ki	0.9	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	Ki	1.1	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	Ki	4.9	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	Ki	7.9	nM	10.1128/aac.01667-08
Influenza A virus	Neuraminidase	Ki	nan	None	10.1016/j.bmc.2009.08.036
Influenza A virus	Neuraminidase	Ki	nan	None	10.1016/j.bmcl.2010.09.077
Influenza A virus	Neuraminidase	Ratio IC50	1.0	None	10.1016/j.bmc.2019.07.013
Influenza A virus (A/Aichi/2/1968(H3N2))	Neuraminidase	IC50	1.55	nM	10.1128/aac.00344-08
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Influenza A virus (A/Puerto Rico/8/1934(H1N1))	EC50	10000.0	nM	10.1021/acs.jmedchem.8b00042
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Neuraminidase	Activity	22.65	%	10.1016/j.bmc.2017.07.006
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Neuraminidase	Activity	32.9	%	10.1016/j.bmc.2017.07.006
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Neuraminidase	Activity	41.9	%	10.1016/j.bmc.2017.07.006
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Neuraminidase	IC50	0.000681	ug.mL-1	10.1016/j.ejmech.2010.01.005
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Neuraminidase	IC50	1.0	nM	10.1021/jm010277p
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Neuraminidase	IC50	7.09	nM	10.1128/aac.00344-08
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Neuraminidase	IC50	50.0	nM	10.1016/j.bmc.2019.07.013
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Neuraminidase	IC50	77.6	nM	10.1021/acs.jnatprod.7b00677
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Neuraminidase	IC50	2600.0	nM	10.1016/j.bmc.2019.07.013
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Neuraminidase	IC50	4071.0	nM	10.1016/j.ejmech.2017.10.004
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	Neuraminidase	Ki	12100.0	nM	10.1016/j.bmc.2017.07.006
Influenza A virus (A/Puerto Rico/8/1934(H1N1))	PA/PB1	IC50	nan	None	10.1021/acs.jmedchem.5b01935
Influenza A virus (A/Udorn/307/1972(H3N2))	Influenza virus A matrix protein M2	EC50	nan	None	10.1016/j.ejmech.2018.09.065
Influenza A virus H3N2	Influenza A virus H3N2	EC50	5700.0	nM	10.1007/s00044-012-0184-x
Influenza A virus H3N2	Influenza A virus H3N2	EC50	11600.0	nM	10.1021/jm801470b
Influenza A virus H3N2	Influenza A virus H3N2	EC50	12000.0	nM	10.1021/jm801470b
Influenza A virus H3N2	Influenza A virus H3N2	EC50	80000.0	nM	10.1021/ml500236n
Influenza A virus H3N2	Influenza A virus H3N2	EC50	100000.0	nM	10.1016/j.bmc.2018.05.034
Influenza A virus H3N2	Influenza A virus H3N2	IC50	1.7	ug.mL-1	10.1016/j.bmcl.2016.06.011
Influenza A virus H3N2	Influenza A virus H3N2	IC50	3.0	nM	10.1021/acs.jnatprod.7b00774
Influenza A virus H3N2	Influenza A virus H3N2	IC50	18.5	nM	10.1021/acs.jnatprod.5b00650
Influenza A virus H3N2	Influenza A virus H3N2	IC50	260.0	nM	10.1016/j.bmc.2008.11.075
Influenza A virus H3N2	Influenza A virus H3N2	IC50	1300.0	nM	10.1021/np4005773
Influenza A virus H3N2	Influenza A virus H3N2	IC50	11300.0	nM	10.1016/j.bmcl.2019.08.009
Influenza A virus H3N2	Influenza A virus H3N2	Inhibition	nan	%	10.1021/ml500236n
Influenza A virus (strain A/USSR/90/1977 H1N1)	Neuraminidase	IC50	1.39	nM	10.1016/j.bmcl.2014.07.010
Influenza A virus (strain A/USSR/90/1977 H1N1)	Neuraminidase	IC50	2.57	nM	10.1016/j.bmcl.2014.07.010
Influenza A virus (strain A/USSR/90/1977 H1N1)	Neuraminidase	IC50	20500.0	nM	10.1016/j.bmc.2014.09.004
Influenza A virus (strain A/USSR/90/1977 H1N1)	Neuraminidase	IC50	88200.0	nM	10.1016/j.bmc.2014.09.004
Influenza B virus	Influenza B virus	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Influenza B virus	Influenza B virus	EC50	1.5	ug.mL-1	10.1016/j.ejmech.2010.07.058
Influenza B virus	Influenza B virus	EC50	2.0	ug.mL-1	10.1016/j.ejmech.2010.07.058
Influenza B virus	Influenza B virus	EC50	50.0	nM	10.1016/j.ejmech.2013.01.015
Influenza B virus	Influenza B virus	EC50	60.0	nM	10.1016/j.ejmech.2013.01.015
Influenza B virus	Influenza B virus	EC50	100.0	ug.mL-1	10.1016/j.ejmech.2010.09.065
Influenza B virus	Influenza B virus	EC50	583.0	nM	10.1039/C2MD20300F
Influenza B virus	Influenza B virus	EC50	820.0	nM	10.1016/j.ejmech.2013.01.015
Influenza B virus	Influenza B virus	EC50	1100.0	nM	10.1016/j.ejmech.2013.05.046
Influenza B virus	Influenza B virus	EC50	2600.0	nM	10.1016/j.bmc.2018.05.034
Influenza B virus	Influenza B virus	EC50	2600.0	nM	10.1021/jm801470b
Influenza B virus	Influenza B virus	EC50	2900.0	nM	10.1016/j.bmc.2018.05.034
Influenza B virus	Influenza B virus	EC50	3520.0	nM	10.1016/j.ejmech.2013.05.044
Influenza B virus	Influenza B virus	EC50	6400.0	nM	10.1021/jm900950d
Influenza B virus	Influenza B virus	EC50	6500.0	nM	10.1016/j.ejmech.2013.06.036
Influenza B virus	Influenza B virus	EC50	12000.0	nM	10.1021/jm900950d
Influenza B virus	Influenza B virus	EC50	13630.0	nM	10.1016/j.ejmech.2013.01.015
Influenza B virus	Influenza B virus	EC50	15000.0	nM	10.1016/j.ejmech.2015.02.028
Influenza B virus	Influenza B virus	EC50	20000.0	nM	10.1016/j.ejmech.2015.02.028
Influenza B virus	Influenza B virus	EC50	21800.0	nM	10.1007/s00044-012-0184-x
Influenza B virus	Influenza B virus	EC50	23000.0	nM	10.1016/j.bmcl.2010.03.080
Influenza B virus	Influenza B virus	EC50	23500.0	nM	10.1016/j.bmc.2011.04.016
Influenza B virus	Influenza B virus	EC50	27000.0	nM	10.1016/j.bmcl.2010.03.080
Influenza B virus	Influenza B virus	EC50	45000.0	nM	10.1016/j.ejmech.2012.03.007
Influenza B virus	Influenza B virus	EC50	77600.0	nM	10.1016/j.ejmech.2012.03.007
Influenza B virus	Influenza B virus	EC50	83240.0	nM	10.1016/j.ejmech.2015.09.037
Influenza B virus	Influenza B virus	EC50	400000.0	nM	10.1021/jm801470b
Influenza B virus	Influenza B virus	IC50	33.17	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza B virus	Influenza B virus	IC50	41.87	ug.mL-1	10.1016/j.bmc.2017.07.006
Influenza B virus	Influenza B virus	IC50	115.0	ug.mL-1	10.1016/j.bmcl.2016.06.011
Influenza B virus	Influenza B virus	IC50	2100.0	nM	10.1016/j.bmc.2008.11.075
Influenza B virus	Influenza B virus	IC50	488300.0	nM	10.1016/j.bmcl.2019.08.009
Influenza B virus	Influenza B virus	IC50	nan	None	10.1016/j.ejmech.2012.07.008
Influenza B virus (strain B/Lee/1940)	Neuraminidase	IC50	5.0	nM	10.1021/jm010277p
Influenza B virus (strain B/Lee/1940)	Neuraminidase	Ki	1.1	nM	10.1016/j.bmcl.2008.01.048
Mammalian orthoreovirus 1	Mammalian orthoreovirus 1	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Mammalian orthoreovirus 1	Mammalian orthoreovirus 1	EC50	nan	None	10.1016/j.bmc.2011.04.016
Mus musculus	Mus musculus	Activity	0.6	g	10.1128/aac.01051-06
Mus musculus	Mus musculus	Activity	76.9	%	10.1128/aac.01051-06
Mus musculus	Mus musculus	Activity	270.0	mg	10.1128/aac.01051-06
Mus musculus	Mus musculus	Activity	nan	None	10.1128/aac.01051-06
Mus musculus	Mus musculus	AUC	8881.82	ng.hr.mL-1	10.1016/j.bmcl.2015.04.059
Mus musculus	Mus musculus	Cmax	13500.0	nM	10.1016/j.bmcl.2015.04.059
Mus musculus	Mus musculus	Cp	8.41	uM	10.1016/j.bmcl.2015.04.059
Mus musculus	Mus musculus	Cp	13.32	uM	10.1016/j.bmcl.2015.04.059
Mus musculus	Mus musculus	F	64.5	%	10.1016/j.bmcl.2015.04.059
Mus musculus	Mus musculus	T1/2	1.233	hr	10.1016/j.bmcl.2015.04.059
Mus musculus	Mus musculus	Tmax	0.5	hr	10.1016/j.bmcl.2015.04.059
Punta Toro virus	Punta Toro virus	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Punta Toro virus	Punta Toro virus	EC50	nan	None	10.1016/j.bmc.2011.04.016
Rattus norvegicus	Brain	Cmax	491.0	ng/g	10.1128/aac.01541-08
Rattus norvegicus	Brain	Cmax	712.0	ng/g	10.1128/aac.01541-08
Rattus norvegicus	Brain	Cmax	2310.0	ng/g	10.1128/aac.01541-08
Rattus norvegicus	Brain	Ratio AUC	1160.0	None	10.1128/aac.01541-08
Rattus norvegicus	Brain	Ratio AUC	1310.0	None	10.1128/aac.01541-08
Rattus norvegicus	Brain	Ratio AUC	13600.0	None	10.1128/aac.01541-08
Rattus norvegicus	Brain	T1/2	1.51	hr	10.1128/aac.01541-08
Rattus norvegicus	Brain	T1/2	2.45	hr	10.1128/aac.01541-08
Rattus norvegicus	Cerebrospinal fluid	Cmax	2871.23	nM	10.1128/aac.01541-08
Rattus norvegicus	Cerebrospinal fluid	Cmax	2948.05	nM	10.1128/aac.01541-08
Rattus norvegicus	Cerebrospinal fluid	Cmax	3585.03	nM	10.1128/aac.01541-08
Rattus norvegicus	Cerebrospinal fluid	Ratio AUC	450.0	None	10.1128/aac.01541-08
Rattus norvegicus	Cerebrospinal fluid	Ratio AUC	472.0	None	10.1128/aac.01541-08
Rattus norvegicus	Cerebrospinal fluid	Ratio AUC	7470.0	None	10.1128/aac.01541-08
Rattus norvegicus	Cerebrospinal fluid	T1/2	0.812	hr	10.1128/aac.01541-08
Rattus norvegicus	Cerebrospinal fluid	T1/2	0.813	hr	10.1128/aac.01541-08
Rattus norvegicus	Plasma	Cmax	38411.06	nM	10.1128/aac.01541-08
Rattus norvegicus	Plasma	Cmax	40011.52	nM	10.1128/aac.01541-08
Rattus norvegicus	Plasma	Cmax	52175.03	nM	10.1128/aac.01541-08
Rattus norvegicus	Plasma	Ratio AUC	5330.0	None	10.1128/aac.01541-08
Rattus norvegicus	Plasma	Ratio AUC	107000.0	None	10.1128/aac.01541-08
Rattus norvegicus	Plasma	T1/2	0.7333	hr	10.1021/jm401492x
Rattus norvegicus	Plasma	T1/2	1.35	hr	10.1128/aac.01541-08
Rattus norvegicus	Plasma	T1/2	1.59	hr	10.1128/aac.01541-08
Rattus norvegicus	Rattus norvegicus	AUC	2200.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	2280.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	2510.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	2680.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	2710.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	2800.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	2810.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	2830.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	2840.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	3010.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	3060.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	3780.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	3810.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	20300.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	26900.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	27100.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	AUC	29500.0	ng.hr.mL-1	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	CL	93.9	mL.min-1.kg-1	10.1128/aac.01541-08
Rattus norvegicus	Rattus norvegicus	Cmax	2964.05	nM	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Cmax	4065.17	nM	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Cmax	4577.32	nM	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Cmax	5217.5	nM	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Cmax	5409.56	nM	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Cmax	6625.91	nM	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Cmax	19653.66	nM	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Cmax	25575.37	nM	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Cmax	33289.59	nM	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Cmax	33609.68	nM	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	F	36.0	%	10.1021/jm401492x
Rattus norvegicus	Rattus norvegicus	Tmax	0.25	hr	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Tmax	0.41	hr	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Tmax	0.5	hr	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Tmax	0.66	hr	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Tmax	0.83	hr	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Tmax	1.0	hr	10.1124/dmd.112.044990
Rattus norvegicus	Rattus norvegicus	Vdss	3.0	L.kg-1	10.1128/aac.01541-08
Respiratory syncytial virus	Respiratory syncytial virus	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Respiratory syncytial virus	Respiratory syncytial virus	EC50	nan	None	10.1016/j.bmc.2011.04.016
Saccharomyces cerevisiae	Saccharomyces cerevisiae	CC50	214500.0	nM	10.1016/j.ejmech.2018.09.065
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	11.4	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	Replicase polyprotein 1ab	Inhibition	12.43	%	10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	EC50	100000.0	nM	10.1016/j.ejmech.2020.112687
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Hit score	0.1622	None	10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50	19952.62	nM	10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	IC50	20000.0	nM	10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	-0.05	%	10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2	SARS-CoV-2	Inhibition	0.57	%	10.6019/CHEMBL4495565
Sindbis virus	Sindbis virus	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Sindbis virus	Sindbis virus	EC50	nan	None	10.1016/j.bmc.2011.04.016
Sus scrofa	LLC-PK1	Papp	10.1	nm/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	Papp	35.2	nm/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	Papp	41.7	nm/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.03	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.04	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.08	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.11	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.12	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.14	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.15	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.27	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.28	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.4	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.42	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.44	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.48	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.82	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.93	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	0.96	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	1.02	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	2.0	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	2.24	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	2.39	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	2.82	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	4.31	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	7.71	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	7.96	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	8.97	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	13.6	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	14.9	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	16.6	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	permeability	18.8	pmol/s	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	Ratio	0.77	None	10.1128/aac.01541-08
Sus scrofa	LLC-PK1	Ratio	9.23	None	10.1128/aac.01541-08
unidentified influenza virus	unidentified influenza virus	IC50	45000.0	nM	10.1016/j.bmc.2008.11.075
Vaccinia virus	Vaccinia virus	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Vesicular stomatitis virus	Vesicular stomatitis virus	Activity	nan	None	10.1016/j.ejmech.2011.11.021
Vesicular stomatitis virus	Vesicular stomatitis virus	EC50	nan	None	10.1016/j.bmc.2011.04.016
None	ADMET	Activity	0.06	%	10.1128/aac.01541-08
None	ADMET	Activity	0.1	%	10.1128/aac.01541-08
None	ADMET	Activity	0.12	%	10.1128/aac.01541-08
None	ADMET	Activity	0.16	%	10.1128/aac.01541-08
None	ADMET	Activity	0.18	%	10.1128/aac.01541-08
None	ADMET	Activity	0.2	pmol/s	10.1128/aac.01541-08
None	ADMET	Activity	0.32	pmol/s	10.1128/aac.01541-08
None	ADMET	Activity	0.33	pmol/s	10.1128/aac.01541-08
None	ADMET	Activity	0.34	pmol/s	10.1128/aac.01541-08
None	ADMET	Activity	0.39	pmol/s	10.1128/aac.01541-08
None	ADMET	Activity	0.41	%	10.1128/aac.01541-08
None	ADMET	Activity	0.52	pmol/s	10.1128/aac.01541-08
None	ADMET	Activity	0.6	pmol/s	10.1128/aac.01541-08
None	ADMET	Activity	0.63	%	10.1128/aac.01541-08
None	ADMET	Activity	1.37	pmol/s	10.1128/aac.01541-08
None	ADMET	Activity	2.11	pmol/s	10.1128/aac.01541-08
None	ADMET	Activity	3.57	%	10.1128/aac.01541-08
None	ADMET	Activity	3.79	%	10.1128/aac.01541-08
None	ADMET	Activity	49.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	70.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	80.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	92.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	112.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	119.0	pmol/s	10.1128/aac.01541-08
None	ADMET	Activity	126.0	pmol/s	10.1128/aac.01541-08
None	ADMET	Activity	467.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	482.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	538.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	574.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	1001.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	1446.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	128137.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	159169.0	nmol	10.1128/aac.01541-08
None	ADMET	Activity	nan	None	10.1128/aac.01541-08
None	ADMET	AUC	3610.0	ng.hr.mL-1	10.1021/jm049276y
None	ADMET	CC50	10000.0	nM	10.1016/j.bmcl.2013.04.033
None	ADMET	CC50	20000.0	nM	10.1016/j.bmc.2013.10.020
None	ADMET	CC50	250000.0	nM	10.1021/acs.jmedchem.5b01935
None	ADMET	Cmax	5281.52	nM	10.1021/jm049276y
None	ADMET	Drug excretion	3.09	%	10.1124/dmd.112.044990
None	ADMET	Drug excretion	4.32	%	10.1124/dmd.112.044990
None	ADMET	Drug uptake	nan	None	10.1124/dmd.112.044990
None	ADMET	F	38.3	%	10.1021/jm049276y
None	ADMET	MNCC	nan	None	10.1007/s00044-010-9338-x
None	ADMET	permeability	nan	None	10.1128/aac.01541-08
None	ADMET	Ratio AUC	0.07	None	10.1128/aac.01541-08
None	ADMET	Ratio AUC	0.09	None	10.1128/aac.01541-08
None	ADMET	Ratio AUC	0.12	None	10.1128/aac.01541-08
None	ADMET	Ratio AUC	0.21	None	10.1128/aac.01541-08
None	ADMET	Ratio AUC	0.24	None	10.1128/aac.01541-08
None	ADMET	Ratio AUC	0.55	None	10.1128/aac.01541-08
None	ADMET	Ratio CC50/EC50	10.0	None	10.1021/acs.jmedchem.2c01329
None	ADMET	Ratio CC50/EC50	600.0	None	10.1016/j.ejmech.2021.113762
None	ADMET	Ratio CC50/EC50	4500.0	None	10.1021/acs.jmedchem.2c01329
None	ADMET	Ratio CC50/IC50	4132.0	None	10.1021/acs.jmedchem.9b01091
None	ADMET	Selectivity Index	1.0	None	10.1016/j.ejmech.2021.113591
None	ADMET	Selectivity Index	58.0	None	10.1016/j.ejmech.2021.113591
None	ADMET	Selectivity Index	98.2	None	10.1016/j.ejmech.2021.113738
None	ADMET	T1/2	1.9	hr	10.1021/jm049276y
None	ADMET	TI	910.5	None	10.1016/j.ejmech.2020.112577
None	Hepatotoxicity	HepSE_bilirubinemia	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cholecystitis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cholelithiasis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_cirrhosis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_Combined Scores	3.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_elevated liver function tests	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatic failure	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatic necrosis	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatitis	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_hepatomegaly	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_jaundice	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver disease	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver fatty	0.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	HepSE_liver function tests abnormal	1.0	None	10.1371/journal.pcbi.1002310
None	Hepatotoxicity	LTKB_BD DILI severity score	3.0	None	10.1016/j.drudis.2011.05.007
None	NON-PROTEIN TARGET	Activity	nan	None	10.1016/j.ejmech.2014.04.082
None	NON-PROTEIN TARGET	EC50	98.0	nM	10.1039/C2MD20300F
None	NON-PROTEIN TARGET	EC50	160.0	nM	10.1021/jm5007275
None	NON-PROTEIN TARGET	EC50	2300.0	nM	10.1016/j.ejmech.2015.02.028
None	NON-PROTEIN TARGET	EC50	4000.0	nM	10.1016/j.ejmech.2015.02.028
None	NON-PROTEIN TARGET	EC50	10000.0	nM	10.1021/jm5007275
None	NON-PROTEIN TARGET	EC50	nan	None	10.1021/jm5007275
None	NON-PROTEIN TARGET	Hepatotoxicity (acute)	0.0	%	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (animal toxicity known)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (benign tumour)	0.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (granulomatous hepatitis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (mechanism)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (moderate)	0.0	%	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (moderate)	0.0	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	Hepatotoxicity (time to onset)	nan	None	10.1016/s0399-8320(04)95062-2
None	NON-PROTEIN TARGET	IC50	2700.0	nM	10.1021/np500951s
None	NON-PROTEIN TARGET	IC50	15000.0	nM	10.1016/j.ejmech.2015.02.006
None	NON-PROTEIN TARGET	IC50	46500.0	nM	10.1016/j.ejmech.2015.02.006
None	NON-PROTEIN TARGET	Inhibition	nan	%	10.1016/j.ejmech.2015.02.006
None	No relevant target	Activity	0.05	%	10.1021/np400817j
None	No relevant target	Activity	12.8	%	10.1021/np400817j
None	No relevant target	LogD	0.36	None	10.1016/j.bmc.2011.06.080
None	No relevant target	LogD	0.36	None	10.1021/jm3008486
None	Unchecked	Activity	0.005	None	10.1021/acs.jmedchem.7b01536
None	Unchecked	Activity	0.009	None	10.1021/acs.jmedchem.7b01536
None	Unchecked	Activity	0.035	None	10.1021/acs.jmedchem.7b01536
None	Unchecked	Activity	0.159	None	10.1021/acs.jmedchem.7b01536
None	Unchecked	Activity	0.164	None	10.1021/acs.jmedchem.7b01536
None	Unchecked	Activity	nan	None	10.1016/j.ejmech.2021.113762
None	Unchecked	Activity	nan	None	10.1021/ml500236n
None	Unchecked	EC50	0.06	nM	10.1021/acs.jmedchem.7b01536
None	Unchecked	EC50	0.11	nM	10.1021/acs.jmedchem.7b01536
None	Unchecked	EC50	0.42	nM	10.1021/acs.jmedchem.7b01536
None	Unchecked	EC50	1.91	nM	10.1021/acs.jmedchem.7b01536
None	Unchecked	EC50	1.97	nM	10.1021/acs.jmedchem.7b01536
None	Unchecked	EC50	12.0	nM	10.1021/acs.jmedchem.7b01536
None	Unchecked	EC50	14.77	nM	10.1016/j.bmc.2017.03.052
None	Unchecked	Hepatotoxicity (acute)	1.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (association with vascular disease)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (choleostasis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (chronic liver disease)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (cirrhosis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (comment)	nan	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (cytolytic)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (malignant tumour)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (severe hepatitis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (steatosis)	0.0	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	Hepatotoxicity (successful reintroduction)	nan	None	10.1016/s0399-8320(04)95062-2
None	Unchecked	IC50	0.76	nM	10.1016/j.bmc.2017.03.052
None	Unchecked	IC50	0.8	nM	10.1016/j.bmc.2017.03.052
None	Unchecked	IC50	2.5	nM	10.1021/acs.jmedchem.2c01258
None	Unchecked	IC50	3.09	nM	10.1128/aac.00333-08
None	Unchecked	IC50	7.25	nM	10.1128/aac.00333-08
None	Unchecked	IC50	8.26	nM	10.1128/aac.00333-08
None	Unchecked	IC50	8.34	nM	10.1128/aac.00333-08
None	Unchecked	IC50	8.35	nM	10.1128/aac.00333-08
None	Unchecked	IC50	8.72	nM	10.1128/aac.00333-08
None	Unchecked	IC50	8.84	nM	10.1128/aac.00333-08
None	Unchecked	IC50	9.16	nM	10.1128/aac.00333-08
None	Unchecked	IC50	9.21	nM	10.1128/aac.00333-08
None	Unchecked	IC50	9.26	nM	10.1128/aac.00333-08
None	Unchecked	IC50	9.44	nM	10.1128/aac.00333-08
None	Unchecked	IC50	9.55	nM	10.1128/aac.00333-08
None	Unchecked	IC50	9.62	nM	10.1128/aac.00333-08
None	Unchecked	IC50	10.1	nM	10.1128/aac.00333-08
None	Unchecked	IC50	10.6	nM	10.1128/aac.00333-08
None	Unchecked	IC50	12.0	nM	10.1128/aac.00333-08
None	Unchecked	IC50	12.4	nM	10.1128/aac.00333-08
None	Unchecked	IC50	13.6	nM	10.1128/aac.00333-08
None	Unchecked	IC50	13.7	nM	10.1128/aac.00333-08
None	Unchecked	IC50	15.1	nM	10.1128/aac.00333-08
None	Unchecked	IC50	15.6	nM	10.1128/aac.00333-08
None	Unchecked	IC50	19.1	nM	10.1021/acs.jnatprod.7b00677
None	Unchecked	IC50	20.0	nM	10.1021/acs.jmedchem.6b01115
None	Unchecked	IC50	40.5	nM	10.1128/aac.00333-08
None	Unchecked	IC50	45.0	nM	10.1021/jm100621s
None	Unchecked	IC50	45.39	nM	10.1016/j.bmcl.2014.07.010
None	Unchecked	IC50	60.0	nM	10.1016/j.ejmech.2021.113762
None	Unchecked	IC50	65.0	nM	10.1021/jm100621s
None	Unchecked	IC50	68.8	nM	10.1128/aac.00333-08
None	Unchecked	IC50	100.0	nM	10.1016/j.bmc.2019.07.013
None	Unchecked	IC50	100.0	nM	10.1016/j.bmcl.2021.127839
None	Unchecked	IC50	104.4	nM	10.1021/jm100621s
None	Unchecked	IC50	140.0	nM	10.1021/np200321s
None	Unchecked	IC50	144.2	nM	10.1021/jm100621s
None	Unchecked	IC50	169.3	nM	10.1016/j.bmc.2017.03.052
None	Unchecked	IC50	182.5	nM	10.1021/jm100621s
None	Unchecked	IC50	188.4	nM	10.1021/jm100621s
None	Unchecked	IC50	659.7	nM	10.1021/jm100621s
None	Unchecked	IC50	708.0	nM	10.1021/jm100621s
None	Unchecked	IC50	990.0	nM	10.1016/j.ejmech.2020.112957
None	Unchecked	IC50	1590.0	nM	10.1016/j.bmcl.2009.12.106
None	Unchecked	IC50	16000.0	nM	10.1016/j.bmc.2015.11.028
None	Unchecked	IC50	33600.0	nM	10.1016/j.ejmech.2017.02.028
None	Unchecked	IC50	46500.0	nM	10.1039/C6MD00292G
None	Unchecked	IC50	85000.0	nM	10.1016/j.bmc.2015.11.028
None	Unchecked	IC50	110000.0	nM	10.1021/np400817j
None	Unchecked	IC50	125000.0	nM	10.1021/np400817j
None	Unchecked	IC50	441300.0	nM	10.1016/j.bmc.2019.07.013
None	Unchecked	Inhibition	72.6	%	10.1039/C6MD00292G
None	Unchecked	Inhibition	nan	%	10.1021/ml500533x
None	Unchecked	Ki	6.0	nM	10.1021/jm100621s
None	Unchecked	Ki	6.7	nM	10.1021/jm100621s
None	Unchecked	Ki	9.9	nM	10.1021/jm100621s
None	Unchecked	Ki	16.6	nM	10.1021/jm100621s
None	Unchecked	Ki	53.4	nM	10.1021/jm100621s
None	Unchecked	Ki	60.7	nM	10.1021/jm100621s
None	Unchecked	Ki	82.0	nM	10.1021/jm100621s
None	Unchecked	Ki	84.0	nM	10.1021/jm100621s
None	Unchecked	Ki	2100.0	nM	10.1016/j.ejmech.2016.05.016
None	Unchecked	Ratio	32.0	None	10.1128/aac.00333-08
None	Unchecked	Ratio	79.0	None	10.1128/aac.00333-08
None	Unchecked	Ratio	330.0	None	10.1128/aac.00333-08
None	Unchecked	Ratio	8400.0	None	10.1128/aac.00333-08
None	Unchecked	Ratio CC50/EC50	1.9	None	10.1016/j.ejmech.2013.05.044
None	Unchecked	Ratio CC50/EC50	6.6	None	10.1016/j.bmc.2017.03.052
None	Unchecked	Ratio CC50/EC50	10.0	None	10.1016/j.ejmech.2013.05.044
None	Unchecked	Ratio CC50/EC50	11.0	None	10.1016/j.ejmech.2013.05.044
None	Unchecked	Ratio CC50/EC50	36.14	None	10.1016/j.bmc.2009.08.036
None	Unchecked	Ratio CC50/EC50	48.0	None	10.1016/j.bmc.2009.08.036
None	Unchecked	Ratio CC50/EC50	299.0	None	10.1021/acs.jmedchem.0c00232
None	Unchecked	Ratio CC50/EC50	326.0	None	10.1016/j.ejmech.2013.05.044
None	Unchecked	Ratio CC50/EC50	781.0	None	10.1039/C6MD00657D
None	Unchecked	Ratio CC50/EC50	1000.0	None	10.1016/j.bmc.2016.09.064
None	Unchecked	Ratio CC50/EC50	10700.0	None	10.1016/j.bmc.2015.11.028
None	Unchecked	Ratio CC50/EC50	16000.0	None	10.1021/acs.jmedchem.5b01935
None	Unchecked	Ratio CC50/IC50	10.8	None	10.1039/C6MD00292G
None	Unchecked	Ratio CC50/IC50	36.2	None	10.1021/acs.jmedchem.6b00326
None	Unchecked	Ratio EC50	200.0	None	10.1021/ml500236n
None	Unchecked	Ratio IC50	0.9	None	10.1021/jm100621s
None	Unchecked	Ratio IC50	1.0	None	10.1021/jm100621s
None	Unchecked	Ratio IC50	1.4	None	10.1021/jm100621s
None	Unchecked	Ratio IC50	2.8	None	10.1021/jm100621s
None	Unchecked	Ratio IC50	4.2	None	10.1021/jm100621s
None	Unchecked	Ratio IC50	4.6	None	10.1021/jm100621s
None	Unchecked	Ratio IC50	5.3	None	10.1016/j.bmc.2015.11.028
None	Unchecked	Ratio IC50	6.8	None	10.1021/jm100621s
None	Unchecked	Ratio IC50	27.0	None	10.1016/j.bmc.2015.11.028
None	Unchecked	Ratio IC50	380.0	None	10.1016/j.bmc.2015.11.028
None	Unchecked	Ratio Ki	4.9	None	10.1021/jm100621s
None	Unchecked	Ratio Ki	8.5	None	10.1021/jm100621s
None	Unchecked	Ratio Ki	8.9	None	10.1021/jm100621s
None	Unchecked	Ratio Ki	9.1	None	10.1021/jm100621s
None	Unchecked	Selectivity Index	10.9	None	10.1016/j.bmcl.2016.06.011
None	Unchecked	Selectivity Index	132.2	None	10.1016/j.bmcl.2019.08.009
None	Unchecked	Selectivity Index	288.4	None	10.1016/j.bmcl.2019.08.009
None	Unchecked	Selectivity Index	320.0	None	10.1016/j.bmcl.2016.06.011
None	Unchecked	Selectivity Index	448.4	None	10.1016/j.ejmech.2014.02.029
None	Unchecked	Selectivity Index	700.0	None	10.1016/j.bmcl.2016.06.011
None	Unchecked	Selectivity Index	741.0	None	10.1021/acs.jnatprod.6b00585
None	Unchecked	Selectivity Index	773.0	None	10.1021/acs.jnatprod.7b01074
None	Unchecked	Selectivity Index	1143.0	None	10.1021/np500951s
None	Unchecked	Selectivity Index	1235.0	None	10.1016/j.ejmech.2014.02.029
None	Unchecked	Selectivity Index	1535.1	None	10.1016/j.ejmech.2012.07.008
None	Unchecked	Selectivity Index	2869.3	None	10.1021/acs.jnatprod.5b00325
None	Unchecked	Selectivity Index	nan	None	10.1016/j.ejmech.2012.07.008
None	Unchecked	Selectivity Index	nan	None	10.1016/j.ejmech.2014.02.029
None	Unchecked	Selectivity Index	nan	None	10.1016/j.ejmech.2021.113161

Metabolism Information

AKRT ID	Reaction	Reaction Link ID
AKRT009702	CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1>>CCC(CC)O[C@@H]1C=C(C(=O)O)C[C@H](N)[C@H]1NC(C)=O	enzymemap_51196
AKRT009703	CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1>>CCC(CC)O[C@@H]1C=C(C(=O)O)C[C@H](N)[C@H]1NC(C)=O.CCO	None
AKRT009704	CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1>>CCO	enzymemap_51196