Anhydrolycorine
AlkaPlorer ID: AK063443
Synonym: ''
IUPAC Name: 5,7-dioxa-12-azoniapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-1(18),2,4(8),9,15(19),16-hexaene
Structure
SMILES: C1=CC2=C3C(=C1)C1=C(C=C4OCOC4=C1)C[NH+]3CC2
InChI: InChI=1S/C16H13NO2/c1-2-10-4-5-17-8-11-6-14-15(19-9-18-14)7-13(11)12(3-1)16(10)17/h1-3,6-7H,4-5,8-9H2/p+1
InChIKey: NWJBCDNATQJZOD-UHFFFAOYSA-O
Reference
HPTLC and GC/MS Study of Amaryllidaceae Alkaloids of Two <i>Narcissus</i> Species
PubChem CID: 163152526
CAS: 641-89-4
LOTUS: LTS0134629
COCONUT: CNP0118849
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Leucojum aestivum | Leucojum | Amaryllidaceae | Asparagales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 252.29299999999992
TPSA？: 22.9
MolLogP？: 1.6684000000000003
Number of H-Donors: 1
Number of H-Acceptors: 2
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | A549 | IC50 | 4500.0 | nM | 10.1021/jm901031h |
| Homo sapiens | NHDF | IC50 | 26600.0 | nM | 10.1021/jm901031h |
| Homo sapiens | SK-MEL-28 | IC50 | 10000.0 | nM | 10.1021/jm901031h |
| Mus musculus | B16-F10 | IC50 | 10000.0 | nM | 10.1021/jm901031h |
| Rhodococcus fascians | Rhodococcus fascians | IZ | 0.0 | mm | 10.1021/np50040a008 |
| Rhodococcus fascians | Rhodococcus fascians | IZ | 15.0 | mm | 10.1021/np50040a008 |
| Rhodococcus fascians | Rhodococcus fascians | IZ | 25.0 | mm | 10.1016/j.bmcl.2017.09.052 |
| Rhodococcus fascians | Rhodococcus fascians | IZ | 25.0 | mm | 10.1021/np50040a008 |
| None | ADMET | IC50 | 23700.0 | nM | 10.1021/jm901031h |
| None | ADMET | IC50 | 30100.0 | nM | 10.1021/jm901031h |
| None | NON-PROTEIN TARGET | IC50 | 5100.0 | nM | 10.1021/jm901031h |
| None | NON-PROTEIN TARGET | IC50 | 7100.0 | nM | 10.1021/jm901031h |
| None | NON-PROTEIN TARGET | IC50 | 8800.0 | nM | 10.1021/jm901031h |