Molecule

Salinosporamide J

AlkaPlorer ID: AK063484

Synonym: None

IUPAC Name: (1R,4R,5S)-4-(2-chloroethyl)-1-(cyclohex-2-en-1-ylmethyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

Structure

SMILES: C[C@@]12OC(=O)[C@]1(CC1C=CCCC1)N=C(O)[C@@H]2CCCl

InChI: InChI=1S/C15H20ClNO3/c1-14-11(7-8-16)12(18)17-15(14,13(19)20-14)9-10-5-3-2-4-6-10/h3,5,10-11H,2,4,6-9H2,1H3,(H,17,18)/t10?,11-,14-,15-/m0/s1

InChIKey: URJGVVMJOFUXRZ-ZJINVJJNSA-N

Reference

Salinosporamides D−J from the Marine Actinomycete <i>Salinispora tropica</i>, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

PubChem CID: 16109824

LOTUS: LTS0054123

NPASS: NPC489631

{

NPAtlas: NPA009262

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
None	Salinispora	Micromonosporaceae	Micromonosporales	Actinomycetes	Actinomycetota	None	Bacteria
Salinispora tropica	Salinispora	Micromonosporaceae	Micromonosporales	Actinomycetes	Actinomycetota	None	Bacteria

Properties Information

Molecule Weight: 297.7819999999999

TPSA？: 58.89

MolLogP？: 3.002300000000001

Number of H-Donors: 1

Number of H-Acceptors: 3

RingCount: 3

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Homo sapiens	RPMI-8226	IC50	250.0	nM	10.1021/np0603471
None	Unchecked	IC50	52.0	nM	10.1021/np0603471