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Nagelamide G

AlkaPlorer ID: AK063587

Synonym: None

IUPAC Name: N-[[(5S,6R,7S)-2-amino-7-(2-amino-1H-imidazol-5-yl)-6-[[(4,5-dibromo-1H-pyrrole-2-carbonyl)amino]methyl]-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl]methyl]-4,5-dibromo-1H-pyrrole-2-carboxamide

Structure

SMILES: N=C1NC=C([C@H]2C3=C(C[C@H](CNC(=O)C4=CC(Br)=C(Br)N4)[C@H]2CNC(=O)C2=CC(Br)=C(Br)N2)NC(=N)N3)N1

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InChI: InChI=1S/C22H22Br4N10O2/c23-9-2-12(32-17(9)25)19(37)29-4-7-1-11-16(36-22(28)34-11)15(14-6-31-21(27)35-14)8(7)5-30-20(38)13-3-10(24)18(26)33-13/h2-3,6-8,15,32-33H,1,4-5H2,(H,29,37)(H,30,38)(H3,27,31,35)(H3,28,34,36)/t7-,8-,15+/m1/s1

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InChIKey: VOGBZMFIZJPYAJ-PISXGGPESA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 778.102

TPSA？: 200.64

MolLogP？: 3.444539999999999

Number of H-Donors: 10

Number of H-Acceptors: 4

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis Bacillus subtilis MIC 16.7 ug.mL-1 10.1021/np034077n
Escherichia coli Escherichia coli MIC 33.3 ug.mL-1 10.1021/np034077n
Micrococcus luteus Micrococcus luteus MIC 2.08 ug.mL-1 10.1021/np034077n
None Unchecked IC50 13000.0 nM 10.1021/np034077n

Metabolism Information