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Sp-600125

AlkaPlorer ID: AK068673

Synonym: None

IUPAC Name: 14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one

Structure

SMILES: OC1=C2C=CC=CC2=C2N=NC3=C2C1=CC=C3

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InChI: InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7,17H

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InChIKey: KRIUNPBAQZGFQA-UHFFFAOYSA-N

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Reference

NPASS: NPC470090

COCONUT: CNP0341961

Source

Species Genus Family Order Class Phylum Kingdom Domain
Mammea siamensis Mammea Calophyllaceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 220.231

TPSA？: 44.95

MolLogP？: 4.427400000000002

Number of H-Donors: 1

Number of H-Acceptors: 3

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus anthracis Anthrax lethal factor Potency 15848.9 nM None
Equus caballus Ferritin light chain Potency 17782.8 nM None
Escherichia coli K-12 Endonuclease 4 Potency 3981.1 nM None
Gallus gallus Tyrosine-protein kinase SRC Activity 89.0 % 10.1042/bj20070797
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Activity 56.0 % 10.1042/bj20070797
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Ki 630.96 nM None
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens 786-0 GI50 27101.92 nM None
Homo sapiens A498 GI50 7030.72 nM None
Homo sapiens A549 GI50 14927.94 nM None
Homo sapiens ACHN GI50 6637.43 nM None
Homo sapiens Activin receptor type-1B Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-1B Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Adaptor-associated kinase Kd 35.0 nM 10.1038/nbt1068
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 3162.3 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 12589.3 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 19952.6 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 25118.9 nM None
Homo sapiens ALK tyrosine kinase receptor Inhibition 50.0 % 10.1016/j.bmc.2011.04.008
Homo sapiens ALK tyrosine kinase receptor Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd nan None 10.1038/nbt1068
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Ki 1584.89 nM None
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Ataxin-2 Potency 15848.9 nM None
Homo sapiens Ataxin-2 Potency 25118.9 nM None
Homo sapiens BMP-2-inducible protein kinase Kd 25.0 nM 10.1038/nbt1068
Homo sapiens BR serine/threonine-protein kinase 1 Ki 794.33 nM None
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Activity 44.0 % 10.1042/bj20070797
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens BT-549 GI50 30760.97 nM None
Homo sapiens CAKI-1 GI50 3564.51 nM None
Homo sapiens CaM kinase I alpha Activity 73.0 % 10.1042/bj20070797
Homo sapiens CaM kinase I alpha Kd 4100.0 nM 10.1038/nbt1068
Homo sapiens CaM kinase I alpha Ki 1584.89 nM None
Homo sapiens CaM kinase I alpha Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Kd 1400.0 nM 10.1038/nbt1068
Homo sapiens CaM kinase I delta Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I gamma Kd 4200.0 nM 10.1038/nbt1068
Homo sapiens CaM kinase II alpha Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II beta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II beta Ki 6309.57 nM None
Homo sapiens CaM kinase II beta Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II delta Ki 1000.0 nM None
Homo sapiens CaM kinase II delta Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II gamma Ki 1584.89 nM None
Homo sapiens CaM kinase II gamma Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 37.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens CaM-kinase kinase alpha Activity 68.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase alpha Kd nan None 10.1038/nbt1068
Homo sapiens CaM-kinase kinase beta Activity 41.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Kd 7500.0 nM 10.1038/nbt1068
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Activity 80.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Ki 7943.28 nM None
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I alpha Ki 316.23 nM None
Homo sapiens Casein kinase I delta Activity 15.0 % 10.1042/bj20070797
Homo sapiens Casein kinase I delta Ki 31.62 nM None
Homo sapiens Casein kinase I delta Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I epsilon Kd 3100.0 nM 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 1 Kd 3700.0 nM 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 1 Ki 6309.57 nM None
Homo sapiens Casein kinase I gamma 1 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Kd nan None 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 2 Ki 1995.26 nM None
Homo sapiens Casein kinase I gamma 2 Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Activity 57.0 % 10.1042/bj20070797
Homo sapiens Casein kinase II Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha Ki 501.19 nM None
Homo sapiens Casein kinase II alpha (prime) Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Ki 1000.0 nM None
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 31.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Caspase-1 Potency 3981.1 nM None
Homo sapiens Caspase-7 Potency 3162.3 nM None
Homo sapiens CCRF-CEM GI50 16069.41 nM None
Homo sapiens CDK3/cyclin E Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 31.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Cell division cycle 7-related protein kinase Ki 1000.0 nM None
Homo sapiens Cerebroside-sulfatase Potency 601.2 nM None
Homo sapiens cGMP-dependent protein kinase 1 beta Ki 1995.26 nM None
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 2 Ki 1584.89 nM None
Homo sapiens c-Jun N-terminal kinase 1 Activity 23.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 1 IC50 40.0 nM 10.1021/jm501212r
Homo sapiens c-Jun N-terminal kinase 1 IC50 40.0 nM 10.1021/jm9003279
Homo sapiens c-Jun N-terminal kinase 1 IC50 40.0 nM 10.1073/pnas.0708800104
Homo sapiens c-Jun N-terminal kinase 1 IC50 110.0 nM 10.1016/j.bmc.2008.02.027
Homo sapiens c-Jun N-terminal kinase 1 IC50 14000.0 nM 10.1021/jm200479c
Homo sapiens c-Jun N-terminal kinase 1 IC50 50000.0 nM 10.1021/jm200479c
Homo sapiens c-Jun N-terminal kinase 1 Kd 100.0 nM 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 1 Ki 125.89 nM None
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Activity 24.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 2 IC50 40.0 nM 10.1021/jm501212r
Homo sapiens c-Jun N-terminal kinase 2 IC50 40.0 nM 10.1021/jm9003279
Homo sapiens c-Jun N-terminal kinase 2 IC50 40.0 nM 10.1073/pnas.0708800104
Homo sapiens c-Jun N-terminal kinase 2 Kd 84.0 nM 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 2 Ki 50.12 nM None
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity -6.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Activity 47.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 3 IC50 90.0 nM 10.1021/jm501212r
Homo sapiens c-Jun N-terminal kinase 3 IC50 90.0 nM 10.1021/jm9003279
Homo sapiens c-Jun N-terminal kinase 3 IC50 90.0 nM 10.1073/pnas.0708800104
Homo sapiens c-Jun N-terminal kinase 3 IC50 190.0 nM 10.1016/j.bmc.2007.03.062
Homo sapiens c-Jun N-terminal kinase 3 IC50 10000.0 nM 10.1016/j.bmc.2013.02.021
Homo sapiens c-Jun N-terminal kinase 3 Inhibition nan % 10.1016/j.bmc.2013.02.021
Homo sapiens c-Jun N-terminal kinase 3 Kd 22.0 nM 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity -6.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens COLO 205 GI50 19543.39 nM None
Homo sapiens Cyclin-dependent kinase 1 Ki 1000.0 nM None
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2 Kd 3200.0 nM 10.1038/nbt1068
Homo sapiens Cyclin-dependent kinase 2 Ki 79.43 nM None
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 50.0 % 10.1042/bj20070797
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 8.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Cyclin-dependent kinase 5 Ki 1000.0 nM None
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Cytochrome P450 1A2 AC50 15.85 nM None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 Potency 25118.9 nM None
Homo sapiens Cytochrome P450 2C9 Potency 31622.8 nM None
Homo sapiens Cytochrome P450 2D6 AC50 398.11 nM None
Homo sapiens Cytochrome P450 2D6 Potency 398.1 nM None
Homo sapiens Cytochrome P450 3A4 AC50 3981.07 nM None
Homo sapiens Cytochrome P450 3A4 Potency 3981.1 nM None
Homo sapiens Death-associated protein kinase 1 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Kd 610.0 nM 10.1038/nbt1068
Homo sapiens Death-associated protein kinase 2 Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Inhibition nan % 10.1021/jm4000215
Homo sapiens Death-associated protein kinase 3 Kd 410.0 nM 10.1038/nbt1068
Homo sapiens Death-associated protein kinase 3 Ki 398.11 nM None
Homo sapiens Death-associated protein kinase 3 Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 15848.9 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 17782.8 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 28183.8 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 31622.8 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 35481.3 nM None
Homo sapiens DNA polymerase beta Potency 31622.8 nM None
Homo sapiens DNA polymerase eta Potency 22387.2 nM None
Homo sapiens DNA polymerase iota Potency 28183.8 nM None
Homo sapiens DNA polymerase kappa Potency 10000.0 nM None
Homo sapiens DU-145 GI50 28183.83 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Activity 58.0 % 10.1042/bj20070797
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Inhibition nan % 10.1021/jm4000215
Homo sapiens Dual specificity protein kinase CLK2 Kd 300.0 nM 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK2 Ki 630.96 nM None
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Kd nan None 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK4 Kd 260.0 nM 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK4 Ki 63.1 nM None
Homo sapiens Dual specificity protein kinase TTK IC50 98.0 nM 10.1021/jm4000215
Homo sapiens Dual specificity protein kinase TTK IC50 2500.0 nM 10.1016/j.bmc.2014.06.027
Homo sapiens Dual specificity protein kinase TTK Kd 98.0 nM 10.1038/nbt1068
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 40.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Ki 125.89 nM None
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 19.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity -5.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Activity 30.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Ki 316.23 nM None
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 4 Ki 7943.28 nM None
Homo sapiens Dual specificty protein kinase CLK1 Kd nan None 10.1038/nbt1068
Homo sapiens EKVX GI50 20044.72 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 39810.7 nM None
Homo sapiens Ephrin type-A receptor 1 Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 2 Ki 3162.28 nM None
Homo sapiens Ephrin type-A receptor 2 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Kd 4000.0 nM 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 3 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 4 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 5 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 6 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 7 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 7 Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 8 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 1 Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 4 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Kd nan None 10.1038/nbt1068
Homo sapiens Epidermal growth factor receptor erbB1 Ki 1995.26 nM None
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 1 Ki 251.19 nM None
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 3 Ki 158.49 nM None
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Flap endonuclease 1 Potency 2993.5 nM None
Homo sapiens Flap endonuclease 1 Potency 19952.6 nM None
Homo sapiens Focal adhesion kinase 1 Kd nan None 10.1038/nbt1068
Homo sapiens Focal adhesion kinase 1 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Ki 1258.93 nM None
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 40.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Activity 81.0 % 10.1042/bj20070797
Homo sapiens Glycogen synthase kinase-3 beta Ki 316.23 nM None
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 Potency 35481.3 nM None
Homo sapiens Guanine nucleotide-binding protein G(i) subunit alpha-1/Regulator of G-protein signaling 12 Potency 25118.9 nM None
Homo sapiens Guanine nucleotide-binding protein G(s), subunit alpha Potency 50118.7 nM None
Homo sapiens HCC 2998 GI50 9616.12 nM None
Homo sapiens HCT-116 GI50 44565.62 nM None
Homo sapiens HCT-15 GI50 8035.26 nM None
Homo sapiens HEK293 Potency 5623.4 nM None
Homo sapiens Hepatocyte growth factor receptor Ki 501.19 nM None
Homo sapiens Hepatocyte growth factor receptor Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 562.3 nM None
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 12589.3 nM None
Homo sapiens Histone-lysine N-methyltransferase MLL Potency 31622.8 nM None
Homo sapiens HL-60 GI50 42072.66 nM None
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 35.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 2 Ki 199.53 nM None
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 56.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 4 Ki 1995.26 nM None
Homo sapiens HOP-62 GI50 69342.58 nM None
Homo sapiens HOP-92 GI50 37583.74 nM None
Homo sapiens Hs-578T GI50 55080.77 nM None
Homo sapiens HT-29 GI50 25882.13 nM None
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 15848.9 nM None
Homo sapiens IGROV-1 GI50 11350.11 nM None
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Activity 49.0 % 10.1042/bj20070797
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Ki 1995.26 nM None
Homo sapiens Insulin-like growth factor I receptor Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Kd nan None 10.1038/nbt1068
Homo sapiens Insulin receptor Ki 501.19 nM None
Homo sapiens Insulin receptor Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase IC50 8000.0 nM 10.1016/j.bmcl.2011.04.149
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Ki 158.49 nM None
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens K562 GI50 48640.72 nM None
Homo sapiens KM12 GI50 2618.18 nM None
Homo sapiens LIM domain kinase 1 Kd nan None 10.1038/nbt1068
Homo sapiens LIM domain kinase 1 Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens LOX IMVI GI50 12823.31 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 12589.3 nM None
Homo sapiens M14 GI50 100000.0 nM None
Homo sapiens Macrophage colony stimulating factor receptor Ki 125.89 nM None
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Malme-3M GI50 16405.9 nM None
Homo sapiens MAP kinase-activated protein kinase 2 Activity 102.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 2 Ki 7943.28 nM None
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Activity 103.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 3 Ki 10000.0 nM None
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Activity 58.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 5 Ki 1584.89 nM None
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Activity 89.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK1 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Activity 86.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 Ki 5011.87 nM None
Homo sapiens MAP kinase ERK2 Potency 10000.0 nM None
Homo sapiens MAP kinase ERK2 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Activity 67.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Activity 110.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase p38 alpha Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Activity 106.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 beta Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase p38 beta Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Activity 82.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 delta Ki 7943.28 nM None
Homo sapiens MAP kinase p38 delta Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Activity 86.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 gamma Kd 2400.0 nM 10.1038/nbt1068
Homo sapiens MAP kinase p38 gamma Ki 6309.57 nM None
Homo sapiens MAP kinase p38 gamma Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Activity 59.0 % 10.1042/bj20070797
Homo sapiens MAP kinase signal-integrating kinase 2 Kd 1000.0 nM 10.1038/nbt1068
Homo sapiens MAP kinase signal-integrating kinase 2 Ki 316.23 nM None
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 1800.0 nM 10.1038/nbt1068
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Activity 15.0 % 10.1042/bj20070797
Homo sapiens Maternal embryonic leucine zipper kinase Ki 398.11 nM None
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens MCF7 GI50 48977.88 nM None
Homo sapiens MDA-MB-231 GI50 65313.06 nM None
Homo sapiens MDA-MB-435 GI50 12823.31 nM None
Homo sapiens MDA-N GI50 15031.42 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 10000.0 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 28183.8 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 35481.3 nM None
Homo sapiens Microtubule-associated protein tau Potency 199.5 nM None
Homo sapiens Microtubule-associated protein tau Potency 3548.1 nM None
Homo sapiens Microtubule-associated protein tau Potency 11220.2 nM None
Homo sapiens Microtubule-associated protein tau Potency 19952.6 nM None
Homo sapiens Misshapen-like kinase 1 Ki 199.53 nM None
Homo sapiens Misshapen-like kinase 1 Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens Misshapen-like kinase 1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase 15 Activity 43.0 % 10.1042/bj20070797
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd nan None 10.1038/nbt1068
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Ki 50.12 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 16.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Ki 316.23 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Mixed lineage kinase 7 Ki 501.19 nM None
Homo sapiens MOLT-4 GI50 20370.42 nM None
Homo sapiens Muscleblind-like protein 1 Potency 10000.0 nM None
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens myosin light chain kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Myosin light chain kinase, smooth muscle Activity 34.0 % 10.1042/bj20070797
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens NCI/ADR-RES GI50 22594.36 nM None
Homo sapiens NCI-H226 GI50 22855.99 nM None
Homo sapiens NCI-H23 GI50 23768.4 nM None
Homo sapiens NCI-H322M GI50 24945.95 nM None
Homo sapiens NCI-H460 GI50 9862.79 nM None
Homo sapiens NCI-H522 GI50 12189.9 nM None
Homo sapiens Nerve growth factor receptor Trk-A Kd nan None 10.1038/nbt1068
Homo sapiens Nerve growth factor receptor Trk-A Ki 1258.93 nM None
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Ki 794.33 nM None
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Niemann-Pick C1 protein Potency 10322.5 nM None
Homo sapiens NT-3 growth factor receptor Ki 7.943 nM None
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 28.0 % 10.1042/bj20121418
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 16360.1 nM None
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 29092.9 nM None
Homo sapiens OVCAR-3 GI50 15310.87 nM None
Homo sapiens OVCAR-4 GI50 31915.38 nM None
Homo sapiens OVCAR-5 GI50 24378.11 nM None
Homo sapiens OVCAR-8 GI50 22029.26 nM None
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 125.0 % 10.1042/bj20121418
Homo sapiens PC-3 GI50 23280.91 nM None
Homo sapiens PDZ-binding kinase Ki 1000.0 nM None
Homo sapiens Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Potency 22387.2 nM None
Homo sapiens Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Potency 26854.5 nM None
Homo sapiens Peripheral myelin protein 22 Potency 84921.4 nM None
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd nan None 10.1038/nbt1068
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 480.0 nM 10.1038/nbt1068
Homo sapiens Phosphorylase kinase gamma subunit 2 Ki 630.96 nM None
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 15.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Kd nan None 10.1038/nbt1068
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Polyadenylate-binding protein 1 IC50 30850.0 nM None
Homo sapiens Polyadenylate-binding protein 1 IC50 66000.0 nM None
Homo sapiens Prelamin-A/C Potency 5.0 nM None
Homo sapiens Protein kinase C alpha Activity 68.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C alpha Kd nan None 10.1038/nbt1068
Homo sapiens Protein kinase C alpha Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Ki 7943.28 nM None
Homo sapiens Protein kinase C delta Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Ki 316.23 nM None
Homo sapiens Protein kinase C gamma Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Ki 5011.87 nM None
Homo sapiens Protein kinase C iota Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Activity 26.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C mu Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C nu Ki 100.0 nM None
Homo sapiens Protein kinase C theta Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Activity 106.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C zeta Ki 7943.28 nM None
Homo sapiens Protein kinase C zeta Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Activity 70.0 % 10.1042/bj20070797
Homo sapiens Protein kinase N2 Ki 7943.28 nM None
Homo sapiens Protein kinase N2 Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 22.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd nan None 10.1038/nbt1068
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Ki 3981.07 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Regulator of G-protein signaling 4 Potency 37685.8 nM None
Homo sapiens Rho-associated protein kinase 1 Ki 1995.26 nM None
Homo sapiens Rho-associated protein kinase 1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Rho-associated protein kinase 2 Ki 3162.28 nM None
Homo sapiens Rho-associated protein kinase 2 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Activity 85.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase 1 Ki 125.89 nM None
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 14.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Activity 55.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 2200.0 nM 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 22.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Activity 70.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd nan None 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 3 Ki 398.11 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Activity 72.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 1700.0 nM 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens RPMI-8226 GI50 18793.17 nM None
Homo sapiens RXF 393 GI50 20749.14 nM None
Homo sapiens Serine/threonine-protein kinase 10 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 16 Kd 510.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 17A Kd 2100.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 17A Ki 39.81 nM None
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17B Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 2 Kd 2300.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 2 Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 16.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 36 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 38-like Kd 2300.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase AKT Activity 97.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT2 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 980.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 19.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Activity 15.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-B Inhibition nan % 10.1021/jm4000215
Homo sapiens Serine/threonine-protein kinase Aurora-B Ki 10.0 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Activity 20.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd 5300.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 4.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Activity 63.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk1 Ki 1258.93 nM None
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Activity 44.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk2 Ki 501.19 nM None
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 29.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase c-TAK1 Activity 49.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase c-TAK1 Ki 3.981 nM None
Homo sapiens Serine/threonine-protein kinase D2 Ki 158.49 nM None
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK1 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Activity 118.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase GAK Kd 38.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Kd 2200.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Activity 31.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase MST2 Inhibition nan % 10.1021/jm4000215
Homo sapiens Serine/threonine-protein kinase MST2 Ki 316.23 nM None
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 10.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 16.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Potency 20749.1 nM None
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Activity 78.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase NEK2 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek4 Ki 1000.0 nM None
Homo sapiens Serine/threonine-protein kinase NEK6 Activity 102.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK6 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Activity 112.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK9 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 1 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Activity 60.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 4 Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Activity 72.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK6 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Activity 82.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK7 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 180.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 39.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PIM1 Ki 501.19 nM None
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Activity 58.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM2 Inhibition nan % 10.1021/jm4000215
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 460.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PIM2 Ki 316.23 nM None
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Activity 17.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM3 Ki 199.53 nM None
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Activity 80.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 770.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PLK4 Ki 199.53 nM None
Homo sapiens Serine/threonine-protein kinase PRKX Ki 1584.89 nM None
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Activity 28.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Ki 251.19 nM None
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 33.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Activity 84.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase SRPK1 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens SF-268 GI50 18450.15 nM None
Homo sapiens SF-295 GI50 22490.55 nM None
Homo sapiens SF-539 GI50 32210.69 nM None
Homo sapiens SH-SY5Y Potency 15848.9 nM None
Homo sapiens SK-MEL-2 GI50 28973.44 nM None
Homo sapiens SK-MEL-28 GI50 37583.74 nM None
Homo sapiens SK-MEL-5 GI50 14621.77 nM None
Homo sapiens SK-OV-3 GI50 20989.4 nM None
Homo sapiens SN12C GI50 14757.07 nM None
Homo sapiens SNB-19 GI50 50003.45 nM None
Homo sapiens SNB-75 GI50 16904.41 nM None
Homo sapiens Sphingomyelin phosphodiesterase Potency 25118.9 nM None
Homo sapiens SR GI50 13091.82 nM None
Homo sapiens Stem cell growth factor receptor Kd nan None 10.1038/nbt1068
Homo sapiens Stem cell growth factor receptor Ki 1258.93 nM None
Homo sapiens Stem cell growth factor receptor Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens SW-620 GI50 10914.4 nM None
Homo sapiens T47D GI50 100000.0 nM None
Homo sapiens TAR DNA-binding protein 43 Potency 6309.6 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Ki 1584.89 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Ki 1584.89 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Thrombopoietin Potency 5011.9 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 39810.7 nM None
Homo sapiens TK-10 GI50 5929.25 nM None
Homo sapiens TRAF2- and NCK-interacting kinase Kd 480.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 12.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL Ki 630.96 nM None
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Ki 199.53 nM None
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 18.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BTK Ki 1258.93 nM None
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Activity 65.0 % 10.1042/bj20070797
Homo sapiens Tyrosine-protein kinase CSK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CTK Ki 501.19 nM None
Homo sapiens Tyrosine-protein kinase FER Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FER Ki 50.12 nM None
Homo sapiens Tyrosine-protein kinase FER Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Ki 79.43 nM None
Homo sapiens Tyrosine-protein kinase FES Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 38.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FRK Ki 63.1 nM None
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FYN Ki 794.33 nM None
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK1 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase JAK2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 IC50 957.0 nM 10.1021/jm800662z
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase LCK Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase Lyn Ki 1000.0 nM None
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase receptor FLT3 Ki 50.12 nM None
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 6.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Ki 63.1 nM None
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Ki 1000.0 nM None
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase SRC Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 64.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Srms Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase SYK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase SYK Ki 63.1 nM None
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TYK2 Ki 1258.93 nM None
Homo sapiens Tyrosine-protein kinase YES Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase YES Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 5956.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 6683.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 8912.5 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 10000.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 20596.2 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 21136.0 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 26608.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29092.9 nM None
Homo sapiens U-251 GI50 23067.47 nM None
Homo sapiens UACC-257 GI50 29512.09 nM None
Homo sapiens UACC-62 GI50 14554.59 nM None
Homo sapiens UO-31 GI50 10543.87 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki 199.53 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Vascular endothelial growth factor receptor 2 Ki 630.96 nM None
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Vascular endothelial growth factor receptor 3 Ki 15.85 nM None
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens Vitamin D receptor Potency 50118.7 nM None
Leishmania major 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Potency 21331.3 nM None
Mus musculus Mitogen-activated protein kinase 8 Inhibition nan % 10.1021/jm200479c
Mus musculus Mus musculus Activity nan None 10.1074/jbc.m705540200
Mus musculus Plasminogen/Urokinase plasminogen activator surface receptor/Urokinase-type plasminogen activator Potency 32885.1 nM None
Mus musculus RAW264.7 IC50 17000.0 nM 10.1016/j.bmc.2012.06.031
Mus musculus RAW264.7 Inhibition 74.6 % 10.1016/j.bmc.2012.06.031
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.bmcl.2013.05.058
Mus musculus Serine/threonine-protein kinase MST2 Kd 220.0 nM 10.1038/nbt1068
Mus musculus Tumor necrosis factor ligand superfamily member 11 Inhibition nan % 10.1021/np500417d
Mus musculus Tyrosine-protein kinase LCK Activity 68.0 % 10.1042/bj20070797
Mus musculus ULK3 kinase Kd 680.0 nM 10.1038/nbt1068
Photinus pyralis Luciferin 4-monooxygenase Potency 28695.4 nM None
Plasmodium falciparum Plasmodium falciparum IC50 7943.28 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 10000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 12589.25 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum Potency 4653.5 nM None
Plasmodium falciparum Plasmodium falciparum Potency 5358.2 nM None
Plasmodium falciparum Plasmodium falciparum Potency 18526.0 nM None
Rattus norvegicus Nuclear factor erythroid 2-related factor 2 Activity nan None 10.1016/j.bmc.2011.01.059
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 2511.9 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 26679.5 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 35481.3 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 89125.1 nM None
Saccharomyces cerevisiae Saccharomyces cerevisiae Potency 12995.3 nM None
Saccharomyces cerevisiae S288c Mitochondrial import inner membrane translocase subunit TIM10 IC50 20200.0 nM None
Saccharomyces cerevisiae S288c Mitochondrial import inner membrane translocase subunit TIM10 IC50 100000.0 nM None
Saccharomyces cerevisiae S288c Mitochondrial import inner membrane translocase subunit TIM23 IC50 6310.0 nM None
Trypanosoma brucei 6-phospho-1-fructokinase Potency 42561.5 nM None
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmc.2013.02.021
None NON-PROTEIN TARGET Potency 2.7 nM None
None NON-PROTEIN TARGET Potency 6678.0 nM None
None NON-PROTEIN TARGET Potency 7943.3 nM None
None NON-PROTEIN TARGET Potency 8912.5 nM None
None NON-PROTEIN TARGET Potency 10000.0 nM None
None NON-PROTEIN TARGET Potency 11220.2 nM None
None NON-PROTEIN TARGET Potency 11875.4 nM None
None NON-PROTEIN TARGET Potency 12589.3 nM None
None Unchecked Activity 31.0 % 10.1042/bj20070797
None Unchecked Activity 44.0 % 10.1042/bj20070797
None Unchecked Inhibition 33.0 % 10.1016/j.bmc.2011.08.067
None Unchecked Inhibition nan % 10.1021/np500417d
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Potency 3981.1 nM None
None Unchecked Potency 5623.4 nM None
None Unchecked Potency 6853.1 nM None
None Unchecked Potency 8196.1 nM None
None Unchecked Potency 8947.4 nM None
None Unchecked Potency 10000.0 nM None
None Unchecked Potency 11220.2 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 18356.4 nM None
None Unchecked Potency 20596.2 nM None
None Unchecked Potency 23109.3 nM None
None Unchecked Potency 29092.9 nM None
None Unchecked Potency 35620.3 nM None
None Unchecked Potency 56234.1 nM None
None Unchecked Selectivity ratio 300.0 None 10.1073/pnas.0708800104

Metabolism Information