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name Structure Reference Source Properties Activities Metabolism

Succinimide

AlkaPlorer ID: AK068962

Synonym: None

IUPAC Name: pyrrolidine-2,5-dione

Structure

SMILES: O=C1CCC(O)=N1

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InChI: InChI=1S/C4H5NO2/c6-3-1-2-4(7)5-3/h1-2H2,(H,5,6,7)

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InChIKey: KZNICNPSHKQLFF-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Uvaria calamistrata Uvaria Annonaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Passiflora incarnata Passiflora Passifloraceae Malpighiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Xanthium strumarium Xanthium Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Nicotiana undulata Nicotiana Solanaceae Solanales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Panax notoginseng Panax Araliaceae Apiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Dacrydium cupressinum Dacrydium Podocarpaceae Araucariales Pinopsida Streptophyta Viridiplantae Eukaryota
Alstonia muelleriana Alstonia Apocynaceae Gentianales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Senecio paludaffinis Senecio Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Glycine tomentella Glycine Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Panax ginseng Panax Araliaceae Apiales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Pterocladiella tenuis Pterocladiella Pterocladiaceae Gelidiales Florideophyceae Rhodophyta None Eukaryota
Haematococcus lacustris Haematococcus Haematococcaceae Chlamydomonadales Chlorophyceae Chlorophyta Viridiplantae Eukaryota
Hypoxylon rubiginosum Hypoxylon Hypoxylaceae Xylariales Sordariomycetes Ascomycota Fungi Eukaryota
Trigonella grandiflora Trigonella Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Tripolium pannonicum Tripolium Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Artemisia cina Artemisia Asteraceae Asterales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 99.089

TPSA？: 49.66

MolLogP？: 0.2633

Number of H-Donors: 1

Number of H-Acceptors: 1

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Glycogen synthase kinase-3 IC50 100000.0 nM 10.1021/jm040895g
Homo sapiens Protein cereblon IC50 22300.0 nM 10.1021/acsmedchemlett.0c00440
Homo sapiens Protein cereblon IC50 34500.0 nM 10.1021/acs.jmedchem.5b01735
Homo sapiens Protein cereblon Ki 8190.0 nM 10.1021/acsmedchemlett.0c00440
Homo sapiens Protein cereblon Ki 26200.0 nM 10.1021/acs.jmedchem.5b01735
Magnetospirillum gryphiswaldense Cereblon isoform 4 IC50 3530.0 nM 10.1021/acsmedchemlett.0c00440
Magnetospirillum gryphiswaldense Cereblon isoform 4 IC50 7600.0 nM 10.1021/acs.jmedchem.5b01735
Magnetospirillum gryphiswaldense Cereblon isoform 4 IC50 53000.0 nM 10.1021/acs.jmedchem.5b01735
Magnetospirillum gryphiswaldense Cereblon isoform 4 Ki 642.0 nM 10.1021/acsmedchemlett.0c00440
Magnetospirillum gryphiswaldense Cereblon isoform 4 Ki 4300.0 nM 10.1021/acs.jmedchem.5b01735
Magnetospirillum gryphiswaldense Cereblon isoform 4 Ki 4300.0 nM 10.1021/acs.jmedchem.9b00454
Magnetospirillum gryphiswaldense Cereblon isoform 4 Ki 47800.0 nM 10.1021/acs.jmedchem.5b01735
Mus musculus Mus musculus Inhibition 2.0 % 10.1021/jm00379a003
Mus musculus Mus musculus Inhibition 27.0 % 10.1021/jm00379a003
Mus musculus Mus musculus Inhibition 32.0 % 10.1021/jm00379a003
Rattus norvegicus Heart Activity nan None 10.1016/j.bmc.2007.02.012
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmc.2007.02.012
None No relevant target LogP -2.31 None 10.1021/jm00218a017
None No relevant target LogP -1.51 None 10.1021/jm00218a017
None Unchecked IC50 6700.0 nM 10.1021/acs.jmedchem.5b01735
None Unchecked Ki 5800.0 nM 10.1021/acs.jmedchem.5b01735

Metabolism Information

AKRT ID Reaction Reaction Link ID
AKRT016815 NC(=O)CCC(=O)O>>O=C1CCC(=O)N1 MNXR131947
AKRT023511 O=C1C=CC(=O)N1>>O=C1CCC(=O)N1 enzymemap_12369
AKRT023517 O=C1CCC(=O)N1>>NC(=O)CCC(=O)O enzymemap_78459