Streptoglutarimide I
AlkaPlorer ID: AK072646
Synonym: None
IUPAC Name: 4-[(2R)-2-hydroxy-2-[(1R,3S,5S)-3-hydroxy-3,5-dimethyl-2-oxocyclohexyl]ethyl]piperidine-2,6-dione
Structure
SMILES: C[C@H]1C[C@H]([C@H](O)CC2CC(=O)N=C(O)C2)C(=O)[C@@](C)(O)C1
InChI: InChI=1S/C15H23NO5/c1-8-3-10(14(20)15(2,21)7-8)11(17)4-9-5-12(18)16-13(19)6-9/h8-11,17,21H,3-7H2,1-2H3,(H,16,18,19)/t8-,10+,11+,15-/m0/s1
InChIKey: SUOBVRUNPIKYHC-DOKDZLDGSA-N
Reference
Bioactive Streptoglutarimides A–J from the Marine-Derived <i>Streptomyces</i> sp. ZZ741
PubChem CID: 145721259
LOTUS: LTS0057479
NPASS: NPC487836
{NPAtlas: NPA025505
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Streptomyces sp. | Streptomyces | Streptomycetaceae | Kitasatosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 297.351
TPSA？: 107.19
MolLogP？: 0.9966999999999996
Number of H-Donors: 3
Number of H-Acceptors: 4
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Candida albicans | Candida albicans | MIC | 12.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00481 |
| Escherichia coli | Escherichia coli | MIC | 9.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00481 |
| Homo sapiens | U-251 | IC50 | nan | None | 10.1021/acs.jnatprod.9b00481 |
| Homo sapiens | U-87 MG | IC50 | nan | None | 10.1021/acs.jnatprod.9b00481 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 11.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00481 |