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Imatinib mesylate

AlkaPlorer ID: AK072680

Synonym: None

IUPAC Name: 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide

Structure

SMILES: CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(C)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1

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InChI: InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)

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InChIKey: KTUFNOKKBVMGRW-UHFFFAOYSA-N

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Reference

PubChem CID: 5291

CAS: 152459-95-5

NPASS: NPC486486

COCONUT: CNP0349372

Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 493.6150000000002

TPSA？: 86.28000000000002

MolLogP？: 4.590320000000004

Number of H-Donors: 2

Number of H-Acceptors: 7

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii MIC 20000.0 nM 10.6019/CHEMBL4513161
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Candida albicans Candida albicans MIC 20000.0 nM 10.6019/CHEMBL4513161
Canis lupus familiaris MDCK Ratio 3.1 None 10.1124/dmd.110.034629
Canis lupus familiaris MDCK-II IC50 65820.0 nM 10.1021/acs.jmedchem.1c00246
Canis lupus familiaris MDCK-II IC50 100000.0 nM 10.1021/acs.jmedchem.1c00246
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Chlorocebus sabaeus Vero C1008 CC50 11900.0 nM 10.6019/CHEMBL4651402
Chlorocebus sabaeus Vero C1008 pCC50 4.93 None 10.6019/CHEMBL4651402
Cricetulus griseus CHO GI50 10000.0 nM 10.1016/j.ejmech.2018.10.007
Cricetulus griseus CHO GI50 10000.0 nM 10.1021/acs.jmedchem.6b00200
Cricetulus griseus CHO GI50 10000.0 nM 10.1021/acs.jmedchem.7b00468
Cryptococcus neoformans Cryptococcus neoformans MIC 20000.0 nM 10.6019/CHEMBL4513161
Danio rerio Danio rerio mortality 0.0 % 10.1021/acs.jmedchem.6b01745
Danio rerio Danio rerio mortality 100.0 % 10.1021/acs.jmedchem.6b01745
Dengue virus Dengue virus Activity nan None 10.1073/pnas.0611681104
Escherichia coli Escherichia coli MIC 20000.0 nM 10.6019/CHEMBL4513161
Gallus gallus Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt1358
Gallus gallus Tyrosine-protein kinase SRC IC50 2784.0 nM 10.1021/jm4004076
Homo sapiens 14-3-3 protein sigma Inhibition nan % 10.1016/j.bmcl.2011.09.011
Homo sapiens 143B Activity 0.951 None 10.1073/pnas.0707498104
Homo sapiens 26S protease regulatory subunit 6B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Activity 34.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Inhibition 34.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Ki 3981.07 nM None
Homo sapiens 5637 Activity 1.122 None 10.1073/pnas.0707498104
Homo sapiens 639-V Activity 1.045 None 10.1073/pnas.0707498104
Homo sapiens 647-V Activity 1.098 None 10.1073/pnas.0707498104
Homo sapiens 697 IC50 245461.96 nM 10.6019/CHEMBL1201861
Homo sapiens 769-P Activity 1.045 None 10.1073/pnas.0707498104
Homo sapiens 786-0 GI 5.0 % 10.1016/j.ejmech.2018.10.062
Homo sapiens 786-0 GI50 16000.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens 8305C Activity 1.085 None 10.1073/pnas.0707498104
Homo sapiens 8505C Activity 0.94 None 10.1073/pnas.0707498104
Homo sapiens 8-MG-BA IC50 199065.91 nM 10.6019/CHEMBL1201861
Homo sapiens A101D IC50 123775.2 nM 10.6019/CHEMBL1201861
Homo sapiens A2058 Activity 0.953 None 10.1073/pnas.0707498104
Homo sapiens A253 cell line IC50 213026.8 nM 10.6019/CHEMBL1201861
Homo sapiens A2780 Activity 1.009 None 10.1073/pnas.0707498104
Homo sapiens A2780 IC50 8900.0 nM 10.1016/j.ejmech.2018.04.029
Homo sapiens A2780 IC50 48000.0 nM 10.1021/jm800988r
Homo sapiens A2780 IC50 50118.72 nM 10.1021/jm800988r
Homo sapiens A-375 Activity 0.932 None 10.1073/pnas.0707498104
Homo sapiens A388 IC50 106545.7 nM 10.6019/CHEMBL1201861
Homo sapiens A3-KAW IC50 406611.43 nM 10.6019/CHEMBL1201861
Homo sapiens A-427 Activity 1.043 None 10.1073/pnas.0707498104
Homo sapiens A-431 Activity 0.973 None 10.1073/pnas.0707498104
Homo sapiens A-431 IC50 31000.0 nM 10.1021/jm800988r
Homo sapiens A-431 IC50 31622.78 nM 10.1021/jm800988r
Homo sapiens A498 GI50 21980.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens A498 IC50 2572.23 nM 10.6019/CHEMBL1201861
Homo sapiens A4-Fuk IC50 474655.37 nM 10.6019/CHEMBL1201861
Homo sapiens A549 Activity 1.236 None 10.1073/pnas.0707498104
Homo sapiens A549 Activity 98.6 % 10.1016/j.ejmech.2011.07.045
Homo sapiens A549 Activity 108.3 % 10.1016/j.ejmech.2011.07.045
Homo sapiens A549 GI 3.8 % 10.1016/j.ejmech.2018.10.062
Homo sapiens A549 GI50 24490.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens A549 IC50 4560.0 nM 10.1016/j.ejmech.2017.05.006
Homo sapiens A549 IC50 15500.0 nM 10.1021/jm800988r
Homo sapiens A549 IC50 19952.62 nM 10.1021/jm800988r
Homo sapiens A549 IC50 25000.0 nM 10.1016/j.ejmech.2018.12.012
Homo sapiens A704 IC50 123555.2 nM 10.6019/CHEMBL1201861
Homo sapiens ABC-1 Activity 0.938 None 10.1073/pnas.0707498104
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens ACHN Activity 0.908 None 10.1073/pnas.0707498104
Homo sapiens ACHN GI -1.0 % 10.1016/j.ejmech.2018.10.062
Homo sapiens ACHN GI50 25230.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens ACN IC50 275653.6 nM 10.6019/CHEMBL1201861
Homo sapiens Actin-related protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Actin-related protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Activin receptor type-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1 Ki 3981.07 nM None
Homo sapiens Activin receptor type-1B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-1B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Activin receptor type-1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-2A Inhibition -2.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Activin receptor type-2A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-2A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Activin receptor type-2B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-2B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Activin receptor type-2B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acyl-CoA dehydrogenase family member 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acyl-CoA dehydrogenase family member 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adaptor-associated kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Adaptor-associated kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Adaptor-associated kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adaptor-associated kinase Kd nan None 10.1038/nbt1068
Homo sapiens Adenine phosphoribosyltransferase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Adenosine kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adenylate kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ADP/ATP translocase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ADP/ATP translocase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AGS Activity 1.117 None 10.1073/pnas.0707498104
Homo sapiens ALK tyrosine kinase receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens ALK tyrosine kinase receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens ALK tyrosine kinase receptor Ki 5011.87 nM None
Homo sapiens ALL-PO IC50 20814.92 nM 10.6019/CHEMBL1201861
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens AM-38 IC50 88395.32 nM 10.6019/CHEMBL1201861
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd nan None 10.1038/nbt1068
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Ki 3981.07 nM None
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Activity 18.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Inhibition 18.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens AMP-activated protein kinase, gamma-1 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, gamma-2 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Ankyrin repeat and protein kinase domain-containing protein 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ankyrin repeat and protein kinase domain-containing protein 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 11220.2 nM None
Homo sapiens ARH-77 IC50 338651.31 nM 10.6019/CHEMBL1201861
Homo sapiens ASPC1 Activity 1.174 None 10.1073/pnas.0707498104
Homo sapiens ASPC1 IC50 39810.72 nM 10.1021/jm800988r
Homo sapiens ASPC1 IC50 44000.0 nM 10.1021/jm800988r
Homo sapiens ATN-1 IC50 212894.34 nM 10.6019/CHEMBL1201861
Homo sapiens ATP-binding cassette sub-family G member 2 Activity nan None 10.1038/nrd3028
Homo sapiens ATP-binding cassette sub-family G member 2 Activity nan None 10.1182/blood-2004-04-1398
Homo sapiens ATP-binding cassette sub-family G member 2 Fluorescence intensity 334.0 a.u. 10.1021/jm050705h
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 500.0 nM 10.1124/mol.65.6.1485
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 900.0 nM 10.1124/mol.65.6.1485
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 3380.0 nM 10.1016/j.bmcl.2009.11.004
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 3710.0 nM 10.1016/j.ejmech.2022.114346
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 4070.0 nM 10.1016/j.bmcl.2009.11.004
Homo sapiens ATP-binding cassette sub-family G member 2 IC50 4897.79 nM 10.1016/j.bmc.2008.07.034
Homo sapiens ATP-dependent RNA helicase DDX1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DDX3X Kd 435.0 nM 10.1126/science.aan4368
Homo sapiens AU565 Activity 0.995 None 10.1073/pnas.0707498104
Homo sapiens BB30-HNC IC50 195983.02 nM 10.6019/CHEMBL1201861
Homo sapiens BB49-HNC IC50 14333.45 nM 10.6019/CHEMBL1201861
Homo sapiens BB65-RCC IC50 131895.51 nM 10.6019/CHEMBL1201861
Homo sapiens BC-3 IC50 180029.55 nM 10.6019/CHEMBL1201861
Homo sapiens BCPAP Activity 0.854 None 10.1073/pnas.0707498104
Homo sapiens Bcr/Abl fusion protein EC50 34.0 nM 10.1021/acs.jmedchem.6b00087
Homo sapiens Bcr/Abl fusion protein EC50 1000.0 nM 10.1021/acs.jmedchem.6b00087
Homo sapiens Bcr/Abl fusion protein FC 0.2253 None 10.1016/j.bmc.2021.116398
Homo sapiens Bcr/Abl fusion protein FC 0.3874 None 10.1016/j.bmc.2021.116398
Homo sapiens Bcr/Abl fusion protein FC 0.7453 None 10.1016/j.bmc.2021.116398
Homo sapiens Bcr/Abl fusion protein GI50 77.1 nM 10.1021/acs.jmedchem.8b01040
Homo sapiens Bcr/Abl fusion protein GI50 90.5 nM 10.1021/acs.jmedchem.8b01040
Homo sapiens Bcr/Abl fusion protein GI50 149.0 nM 10.1021/acs.jmedchem.8b01040
Homo sapiens Bcr/Abl fusion protein GI50 201.0 nM 10.1021/acs.jmedchem.8b01040
Homo sapiens Bcr/Abl fusion protein GI50 249.0 nM 10.1021/acs.jmedchem.8b01040
Homo sapiens Bcr/Abl fusion protein GI50 290.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Bcr/Abl fusion protein GI50 380.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens Bcr/Abl fusion protein GI50 455.0 nM 10.1021/acs.jmedchem.8b01040
Homo sapiens Bcr/Abl fusion protein GI50 625.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens Bcr/Abl fusion protein GI50 650.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Bcr/Abl fusion protein GI50 659.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens Bcr/Abl fusion protein GI50 836.0 nM 10.1021/acs.jmedchem.8b01040
Homo sapiens Bcr/Abl fusion protein GI50 838.0 nM 10.1021/acs.jmedchem.8b01040
Homo sapiens Bcr/Abl fusion protein GI50 850.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Bcr/Abl fusion protein GI50 874.0 nM 10.1021/acs.jmedchem.8b01040
Homo sapiens Bcr/Abl fusion protein GI50 950.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Bcr/Abl fusion protein GI50 1170.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Bcr/Abl fusion protein GI50 1690.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens Bcr/Abl fusion protein GI50 2169.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens Bcr/Abl fusion protein GI50 2240.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Bcr/Abl fusion protein GI50 3750.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Bcr/Abl fusion protein GI50 9645.0 nM 10.1021/acs.jmedchem.8b01040
Homo sapiens Bcr/Abl fusion protein GI50 10000.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Bcr/Abl fusion protein GI50 10000.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens Bcr/Abl fusion protein IC50 1.1 nM 10.1021/jm901132v
Homo sapiens Bcr/Abl fusion protein IC50 2.79 nM 10.1016/j.ejmech.2022.114425
Homo sapiens Bcr/Abl fusion protein IC50 13.0 nM 10.1016/j.ejmech.2015.09.034
Homo sapiens Bcr/Abl fusion protein IC50 14.0 nM 10.1016/j.bmc.2014.10.030
Homo sapiens Bcr/Abl fusion protein IC50 14.0 nM 10.1016/j.ejmech.2015.07.015
Homo sapiens Bcr/Abl fusion protein IC50 25.0 nM 10.1016/j.ejmech.2022.114442
Homo sapiens Bcr/Abl fusion protein IC50 38.0 nM 10.1016/j.bmcl.2018.06.043
Homo sapiens Bcr/Abl fusion protein IC50 38.02 nM 10.1016/j.bmcl.2013.01.113
Homo sapiens Bcr/Abl fusion protein IC50 54.0 nM 10.1016/j.bmc.2021.116398
Homo sapiens Bcr/Abl fusion protein IC50 54.0 nM 10.1016/j.ejmech.2019.05.091
Homo sapiens Bcr/Abl fusion protein IC50 74.0 nM 10.1016/j.bmcl.2015.08.013
Homo sapiens Bcr/Abl fusion protein IC50 100.0 nM 10.1016/j.ejmech.2019.112029
Homo sapiens Bcr/Abl fusion protein IC50 115.64 nM 10.1016/j.ejmech.2022.114425
Homo sapiens Bcr/Abl fusion protein IC50 116.0 nM 10.1016/j.bmc.2013.10.040
Homo sapiens Bcr/Abl fusion protein IC50 143.8 nM 10.1016/j.bmcl.2019.126758
Homo sapiens Bcr/Abl fusion protein IC50 176.0 nM 10.1016/j.ejmech.2020.112710
Homo sapiens Bcr/Abl fusion protein IC50 194.0 nM 10.1016/j.bmc.2013.03.038
Homo sapiens Bcr/Abl fusion protein IC50 204.0 nM 10.1038/nchembio760
Homo sapiens Bcr/Abl fusion protein IC50 221.0 nM 10.1016/j.bmc.2010.08.026
Homo sapiens Bcr/Abl fusion protein IC50 221.0 nM 10.1016/j.bmc.2013.03.038
Homo sapiens Bcr/Abl fusion protein IC50 260.0 nM 10.1016/j.ejmech.2021.113867
Homo sapiens Bcr/Abl fusion protein IC50 280.0 nM 10.1016/j.bmc.2021.116398
Homo sapiens Bcr/Abl fusion protein IC50 280.0 nM 10.1016/j.ejmech.2019.05.091
Homo sapiens Bcr/Abl fusion protein IC50 309.0 nM 10.1016/j.bmcl.2011.02.029
Homo sapiens Bcr/Abl fusion protein IC50 330.0 nM None
Homo sapiens Bcr/Abl fusion protein IC50 340.0 nM 10.1016/j.ejmech.2015.09.034
Homo sapiens Bcr/Abl fusion protein IC50 364.0 nM 10.1016/j.bmcl.2019.126758
Homo sapiens Bcr/Abl fusion protein IC50 399.0 nM 10.1016/j.bmcl.2015.07.006
Homo sapiens Bcr/Abl fusion protein IC50 405.3 nM 10.1016/j.bmcl.2019.126758
Homo sapiens Bcr/Abl fusion protein IC50 473.0 nM 10.1016/j.bmc.2010.08.026
Homo sapiens Bcr/Abl fusion protein IC50 486.5 nM 10.1016/j.bmcl.2019.126758
Homo sapiens Bcr/Abl fusion protein IC50 678.0 nM 10.1016/j.bmc.2013.03.038
Homo sapiens Bcr/Abl fusion protein IC50 716.3 nM 10.1016/j.bmcl.2019.126758
Homo sapiens Bcr/Abl fusion protein IC50 750.0 nM 10.1016/j.bmc.2010.01.051
Homo sapiens Bcr/Abl fusion protein IC50 799.3 nM 10.1016/j.bmcl.2019.126758
Homo sapiens Bcr/Abl fusion protein IC50 1000.0 nM 10.1016/j.bmcl.2015.07.006
Homo sapiens Bcr/Abl fusion protein IC50 1000.0 nM 10.1021/acs.jmedchem.0c00507
Homo sapiens Bcr/Abl fusion protein IC50 6400.0 nM 10.1016/j.ejmech.2021.113867
Homo sapiens Bcr/Abl fusion protein IC50 8778.0 nM 10.1016/j.bmcl.2019.126758
Homo sapiens Bcr/Abl fusion protein IC50 100000.0 nM 10.1016/j.ejmech.2020.112710
Homo sapiens Bcr/Abl fusion protein Inhibition 82.8 % 10.1016/j.bmcl.2016.01.068
Homo sapiens Bcr/Abl fusion protein Inhibition nan % 10.1016/j.bmcl.2016.09.041
Homo sapiens Bcr/Abl fusion protein Inhibition nan % 10.1016/j.ejmech.2014.03.054
Homo sapiens Bcr/Abl fusion protein Inhibition nan % 10.1016/j.ejmech.2018.09.048
Homo sapiens Bcr/Abl fusion protein Inhibition nan % 10.1021/acs.jmedchem.5b01618
Homo sapiens Bcr/Abl fusion protein Inhibition nan % 10.1021/jm200720n
Homo sapiens Bcr/Abl fusion protein Ki 14.0 nM 10.1016/j.chembiol.2005.04.011
Homo sapiens BCR/ABL p210 fusion protein GI50 270.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens BE-13 IC50 2621.06 nM 10.6019/CHEMBL1201861
Homo sapiens Becker IC50 82348.07 nM 10.6019/CHEMBL1201861
Homo sapiens BEN Activity 0.956 None 10.1073/pnas.0707498104
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens BFTC-905 Activity 1.057 None 10.1073/pnas.0707498104
Homo sapiens BFTC-909 Activity 1.156 None 10.1073/pnas.0707498104
Homo sapiens BHT-101 Activity 0.798 None 10.1073/pnas.0707498104
Homo sapiens Bile acid receptor FXR Activity 14.5 % 10.1016/j.bmc.2014.02.049
Homo sapiens Bile salt export pump IC50 10000.0 nM 10.1124/dmd.112.047068
Homo sapiens Bile salt export pump IC50 25100.0 nM 10.1002/hep.27206
Homo sapiens Bile salt export pump IC50 25100.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bile salt export pump IC50 25100.0 nM 10.1093/toxsci/kft176
Homo sapiens BJ GI50 40000.0 nM 10.1016/j.ejmech.2019.111663
Homo sapiens BL-41 IC50 372929.35 nM 10.6019/CHEMBL1201861
Homo sapiens BL-70 IC50 353803.62 nM 10.6019/CHEMBL1201861
Homo sapiens BMP-2-inducible protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BMP-2-inducible protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens BMP-2-inducible protein kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens BMP-2-inducible protein kinase Kd nan None 10.1038/nbt1068
Homo sapiens BOKU IC50 111071.48 nM 10.6019/CHEMBL1201861
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-1B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Bone morphogenetic protein receptor type-1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Brain glycogen phosphorylase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Breakpoint cluster region protein Kd 7.0 nM 10.1126/science.aan4368
Homo sapiens BR serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BR serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens BR serine/threonine-protein kinase 1 Ki 10000.0 nM None
Homo sapiens BR serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BR serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens BT-474 Activity 1.062 None 10.1073/pnas.0707498104
Homo sapiens BT-474 IC50 468410.01 nM 10.6019/CHEMBL1201861
Homo sapiens BT-549 Activity 1.023 None 10.1073/pnas.0707498104
Homo sapiens BT-549 GI -5.0 % 10.1016/j.ejmech.2018.10.062
Homo sapiens BT-549 GI50 16110.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens BV-173 IC50 187.4 nM 10.6019/CHEMBL1201861
Homo sapiens BXPC-3 Activity 1.186 None 10.1073/pnas.0707498104
Homo sapiens C2BBe1 IC50 211377.15 nM 10.6019/CHEMBL1201861
Homo sapiens C32 Activity 1.071 None 10.1073/pnas.0707498104
Homo sapiens C-33-A Activity 1.102 None 10.1073/pnas.0707498104
Homo sapiens C8166 IC50 89612.52 nM 10.6019/CHEMBL1201861
Homo sapiens CA46 IC50 347544.95 nM 10.6019/CHEMBL1201861
Homo sapiens Caco-2 Activity 0.973 None 10.1073/pnas.0707498104
Homo sapiens Caco-2 logPapp 4.89 None 10.1016/j.bmc.2009.08.022
Homo sapiens CAKI-1 Activity 0.882 None 10.1073/pnas.0707498104
Homo sapiens CAKI-1 GI -0.2 % 10.1016/j.ejmech.2018.10.062
Homo sapiens CAKI-1 GI50 33960.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens CAL-120 Activity 1.066 None 10.1073/pnas.0707498104
Homo sapiens CAL-12T Activity 1.062 None 10.1073/pnas.0707498104
Homo sapiens CAL-148 Activity 0.884 None 10.1073/pnas.0707498104
Homo sapiens CAL-148 IC50 327769.63 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-27 IC50 19952.62 nM 10.1021/jm800988r
Homo sapiens CAL-27 IC50 22000.0 nM 10.1021/jm800988r
Homo sapiens CAL-51 Activity 0.916 None 10.1073/pnas.0707498104
Homo sapiens CAL-54 Activity 1.114 None 10.1073/pnas.0707498104
Homo sapiens CAL-62 Activity 1.011 None 10.1073/pnas.0707498104
Homo sapiens CAL-85-1 Activity 1.057 None 10.1073/pnas.0707498104
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Calu-1 Activity 1.136 None 10.1073/pnas.0707498104
Homo sapiens Calu-3 Activity 1.339 None 10.1073/pnas.0707498104
Homo sapiens Calu-6 IC50 33185.47 nM 10.6019/CHEMBL1201861
Homo sapiens CaM kinase I alpha Inhibition 10.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens CaM kinase I alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase I alpha Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase I alpha Ki 6309.57 nM None
Homo sapiens CaM kinase I delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I delta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase I delta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase I delta Ki 2511.89 nM None
Homo sapiens CaM kinase I gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase I gamma Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II alpha Inhibition 1.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens CaM kinase II alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase II alpha Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II alpha Ki 6309.57 nM None
Homo sapiens CaM kinase II beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase II beta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II beta Ki 7943.28 nM None
Homo sapiens CaM kinase II delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II delta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase II delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase II delta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II delta Ki 6309.57 nM None
Homo sapiens CaM kinase II gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase II gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase II gamma Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II gamma Ki 6309.57 nM None
Homo sapiens CaM kinase IV Inhibition 3.0 % 10.1038/nchembio760
Homo sapiens CaM kinase IV Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase IV Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase IV Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM-kinase kinase alpha Activity 1.4 % 10.1021/jm101396q
Homo sapiens CaM-kinase kinase alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM-kinase kinase alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM-kinase kinase alpha Kd nan None 10.1038/nbt1068
Homo sapiens CaM-kinase kinase beta Activity 2.1 % 10.1021/jm101396q
Homo sapiens CaM-kinase kinase beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM-kinase kinase beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM-kinase kinase beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM-kinase kinase beta Kd nan None 10.1038/nbt1068
Homo sapiens CaM-kinase kinase beta Ki 2511.89 nM None
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Ki 3162.28 nM None
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Inhibition 1.0 % 10.1038/nchembio760
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase, gamma catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase (PKA) IC50 500000.0 nM 10.1016/S0960-894X(96)00601-4
Homo sapiens cAMP-dependent protein kinase type II-alpha regulatory subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens CAPAN-1 Activity 1.037 None 10.1073/pnas.0707498104
Homo sapiens Capan-2 Activity 1.009 None 10.1073/pnas.0707498104
Homo sapiens CaR-1 Activity 1.032 None 10.1073/pnas.0707498104
Homo sapiens Carbonic anhydrase I Ki 31.9 nM 10.1016/j.bmcl.2009.06.002
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki 30.2 nM 10.1016/j.bmcl.2009.06.002
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Carbonic anhydrase III Ki 528.0 nM 10.1016/j.bmcl.2009.06.002
Homo sapiens Carbonic anhydrase IV Ki 4553.0 nM 10.1016/j.bmcl.2009.06.002
Homo sapiens Carbonic anhydrase IX Ki 75.7 nM 10.1016/j.bmcl.2009.06.002
Homo sapiens Carbonic anhydrase VA Ki 20200.0 nM 10.1016/j.bmcl.2009.06.002
Homo sapiens Carbonic anhydrase VB Ki 17005.0 nM 10.1016/j.bmcl.2009.06.002
Homo sapiens Carbonic anhydrase VI Ki 392.0 nM 10.1016/j.bmcl.2009.06.002
Homo sapiens Carbonic anhydrase VII Ki 109.0 nM 10.1016/j.bmcl.2009.06.002
Homo sapiens Carbonic anhydrase XII Ki 980.0 nM 10.1016/j.bmcl.2009.06.002
Homo sapiens Carbonic anhydrase XIV Ki 468.0 nM 10.1016/j.bmcl.2009.06.002
Homo sapiens CAS-1 IC50 73885.75 nM 10.6019/CHEMBL1201861
Homo sapiens Casein kinase I alpha Activity 0.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Casein kinase I alpha Inhibition 0.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Casein kinase I alpha Inhibition 11.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Casein kinase I alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I alpha Ki 5011.87 nM None
Homo sapiens Casein kinase I delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I delta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I delta Ki 7943.28 nM None
Homo sapiens Casein kinase I epsilon Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I epsilon Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I epsilon Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I epsilon Kd nan None 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I gamma 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I gamma 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 1 Kd nan None 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 1 Ki 6309.57 nM None
Homo sapiens Casein kinase I gamma 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I gamma 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I gamma 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 2 Kd nan None 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 2 Ki 7943.28 nM None
Homo sapiens Casein kinase II alpha Inhibition 17.0 % 10.1038/nchembio760
Homo sapiens Casein kinase II alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase II alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase II alpha Ki 3981.07 nM None
Homo sapiens Casein kinase II alpha (prime) Kd 3843.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase II alpha (prime) Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase II alpha (prime) Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I isoform alpha-like Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I isoform alpha-like Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I isoform gamma-3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I isoform gamma-3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I isoform gamma-3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I isoform gamma-3 Ki 6309.57 nM None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CCF-STTG1 Activity 1.104 None 10.1073/pnas.0707498104
Homo sapiens CCRF-CEM GI 6.6 % 10.1016/j.ejmech.2018.10.062
Homo sapiens CCRF-CEM GI 6.6 % 10.1016/j.ejmech.2020.112710
Homo sapiens CCRF-CEM GI50 16980.0 nM 10.1016/j.ejmech.2020.112710
Homo sapiens CCRF-CEM GI50 16980.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens CCRF-CEM GI50 35809.0 nM 10.1016/j.ejmech.2019.111663
Homo sapiens CCRF-CEM IC50 36000.0 nM 10.1021/jm800988r
Homo sapiens CCRF-CEM IC50 39810.72 nM 10.1021/jm800988r
Homo sapiens CCRF-CEM IC50 45000.0 nM 10.1016/j.ejmech.2014.03.054
Homo sapiens CCRF-CEM IC50 314489.6 nM 10.6019/CHEMBL1201861
Homo sapiens CCRF-CEM/VCR-1000 IC50 37000.0 nM 10.1021/jm800988r
Homo sapiens CCRF-CEM/VCR-1000 IC50 39810.72 nM 10.1021/jm800988r
Homo sapiens CDK2/Cyclin A1 Activity -2.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens CDK2/Cyclin A2 Inhibition -2.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Cell division cycle 2-like protein kinase 6 Kd 5500.0 nM 10.1038/nbt1358
Homo sapiens Cell division cycle 2-like protein kinase 6 Kd 5500.0 nM 10.1038/nbt.1990
Homo sapiens Cell division cycle 7-related protein kinase Ki 1258.93 nM None
Homo sapiens Cell division protein kinase 8 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cell division protein kinase 8 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cell division protein kinase 8 Ki 3981.07 nM None
Homo sapiens CESS IC50 367188.01 nM 10.6019/CHEMBL1201861
Homo sapiens CFPAC-1 Activity 0.569 None 10.1073/pnas.0707498104
Homo sapiens cGMP-dependent protein kinase 1 beta Inhibition 4.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cGMP-dependent protein kinase 1 beta Ki 1995.26 nM None
Homo sapiens cGMP-dependent protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cGMP-dependent protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens cGMP-dependent protein kinase 2 Ki 1584.89 nM None
Homo sapiens CGTH-W-1 IC50 383.74 nM 10.6019/CHEMBL1201861
Homo sapiens ChaGo-K-1 Activity 1.422 None 10.1073/pnas.0707498104
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Choline-phosphate cytidylyltransferase A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CHP-126 IC50 50890.54 nM 10.6019/CHEMBL1201861
Homo sapiens Chromodomain-helicase-DNA-binding protein 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Citron Rho-interacting kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Citron Rho-interacting kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Citron Rho-interacting kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 1 Activity 14.0 % 10.1021/jm101396q
Homo sapiens c-Jun N-terminal kinase 1 Inhibition -11.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens c-Jun N-terminal kinase 1 Kd 3200.0 nM 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 1 Kd 5000.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 1 Kd 5000.0 nM 10.1038/nbt.1990
Homo sapiens c-Jun N-terminal kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 1 Ki 2511.89 nM None
Homo sapiens c-Jun N-terminal kinase 2 Activity 75.0 % 10.1021/jm101396q
Homo sapiens c-Jun N-terminal kinase 2 Inhibition 10.0 % 10.1038/nchembio760
Homo sapiens c-Jun N-terminal kinase 2 Inhibition 23.0 % 10.1038/nchembio760
Homo sapiens c-Jun N-terminal kinase 2 Kd 5200.0 nM 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens c-Jun N-terminal kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 2 Ki 3981.07 nM None
Homo sapiens c-Jun N-terminal kinase 3 Activity 5.6 % 10.1021/jm101396q
Homo sapiens c-Jun N-terminal kinase 3 Kd 3100.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 3 Kd 3100.0 nM 10.1038/nbt.1990
Homo sapiens c-Jun N-terminal kinase 3 Kd 3300.0 nM 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 3 Ki 1000.0 nM None
Homo sapiens CMK IC50 205054.75 nM 10.6019/CHEMBL1201861
Homo sapiens COLO 205 Activity 1.254 None 10.1073/pnas.0707498104
Homo sapiens COLO 205 GI -1.1 % 10.1016/j.ejmech.2018.10.062
Homo sapiens COLO 205 GI50 17620.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens COLO 320 Activity 1.123 None 10.1073/pnas.0707498104
Homo sapiens COLO 320DM Activity 1.085 None 10.1073/pnas.0707498104
Homo sapiens COLO-320-HSR IC50 353917.56 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-668 IC50 181629.7 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-684 IC50 96238.55 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-800 IC50 137555.85 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-824 IC50 116287.55 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-829 IC50 72698.66 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L23 Activity 0.96 None 10.1073/pnas.0707498104
Homo sapiens COR-L279 IC50 391934.21 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L88 IC50 158231.95 nM 10.6019/CHEMBL1201861
Homo sapiens CP66-MEL IC50 107750.78 nM 10.6019/CHEMBL1201861
Homo sapiens CP67-MEL IC50 163494.28 nM 10.6019/CHEMBL1201861
Homo sapiens CPC-N IC50 315269.55 nM 10.6019/CHEMBL1201861
Homo sapiens CRO-AP2 IC50 424832.09 nM 10.6019/CHEMBL1201861
Homo sapiens CTB-1 IC50 90635.68 nM 10.6019/CHEMBL1201861
Homo sapiens CTV-1 IC50 33978.87 nM 10.6019/CHEMBL1201861
Homo sapiens CW-2 IC50 356640.4 nM 10.6019/CHEMBL1201861
Homo sapiens Cyclin-dependent kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 1 Ki 7943.28 nM None
Homo sapiens Cyclin-dependent kinase 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 12 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 13 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 13 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 1/Cyclin A1 Inhibition -31.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 10000.0 nM 10.1016/j.bmcl.2016.05.004
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Cyclin-dependent kinase 2 IC50 100000.0 nM 10.1016/j.ejmech.2019.111780
Homo sapiens Cyclin-dependent kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Cyclin-dependent kinase 2 Ki 7943.28 nM None
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 10000.0 nM 10.1016/j.bmcl.2016.05.004
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 100000.0 nM 10.1016/j.bmc.2015.02.026
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 100000.0 nM 10.1016/j.ejmech.2014.03.054
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 100000.0 nM 10.1016/j.ejmech.2015.12.023
Homo sapiens Cyclin-dependent kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Cyclin-dependent kinase 5 Ki 6309.57 nM None
Homo sapiens Cyclin-dependent kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 7 Ki 3981.07 nM None
Homo sapiens Cyclin-dependent kinase 9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 9 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 9 Ki 1584.89 nM None
Homo sapiens Cyclin-dependent kinase-like 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase-like 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase-like 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase-like 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteine--tRNA ligase, cytoplasmic Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome c1, heme protein, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Inhibition 10.0 % 10.1016/j.ejmech.2019.112029
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Inhibition 10.0 % 10.1016/j.ejmech.2019.112029
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Inhibition 10.0 % 10.1016/j.ejmech.2019.112029
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Inhibition 10.0 % 10.1016/j.ejmech.2019.112029
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition 40.0 % 10.1016/j.ejmech.2019.112029
Homo sapiens Cytochrome P450 3A4 Ki 14300.0 nM 10.1021/jm300065h
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Kinact 0.07 /min 10.1021/jm300065h
Homo sapiens D-247MG IC50 82024.83 nM 10.6019/CHEMBL1201861
Homo sapiens D-263MG IC50 176468.96 nM 10.6019/CHEMBL1201861
Homo sapiens D283 Med IC50 180490.29 nM 10.6019/CHEMBL1201861
Homo sapiens D-336MG IC50 45959.93 nM 10.6019/CHEMBL1201861
Homo sapiens D-502MG IC50 135926.19 nM 10.6019/CHEMBL1201861
Homo sapiens DAN-G Activity 1.393 None 10.1073/pnas.0707498104
Homo sapiens Daoy Activity 1.202 None 10.1073/pnas.0707498104
Homo sapiens Daoy FC 0.98 None 10.1021/ml400014t
Homo sapiens Daudi IC50 330364.64 nM 10.6019/CHEMBL1201861
Homo sapiens DB IC50 364118.37 nM 10.6019/CHEMBL1201861
Homo sapiens dCTP pyrophosphatase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Death-associated protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Death-associated protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Death-associated protein kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Death-associated protein kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Death-associated protein kinase 3 Kd nan None 10.1038/nbt1068
Homo sapiens Death-associated protein kinase 3 Ki 3981.07 nM None
Homo sapiens DEL IC50 208338.88 nM 10.6019/CHEMBL1201861
Homo sapiens Delta(24)-sterol reductase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Deoxycytidine kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DG-75 IC50 473402.98 nM 10.6019/CHEMBL1201861
Homo sapiens Discoidin domain-containing receptor 2 Activity 7.4 % 10.1021/jm101396q
Homo sapiens Discoidin domain-containing receptor 2 GI50 7700.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens Discoidin domain-containing receptor 2 GI50 10000.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Discoidin domain-containing receptor 2 IC50 141.0 nM 10.1016/j.bmc.2010.08.026
Homo sapiens Discoidin domain-containing receptor 2 IC50 675.0 nM 10.1021/jm5012319
Homo sapiens Discoidin domain-containing receptor 2 Kd 15.0 nM 10.1038/nbt1358
Homo sapiens Discoidin domain-containing receptor 2 Kd 15.0 nM 10.1038/nbt.1990
Homo sapiens Discoidin domain-containing receptor 2 Kd 181.0 nM 10.1126/science.aan4368
Homo sapiens DJM-1 IC50 168102.51 nM 10.6019/CHEMBL1201861
Homo sapiens DLD-1 Activity 0.968 None 10.1073/pnas.0707498104
Homo sapiens DLD-1 Activity 89.9 % 10.1016/j.ejmech.2011.07.045
Homo sapiens DLD-1 Activity 91.5 % 10.1016/j.ejmech.2011.07.045
Homo sapiens DMS-114 IC50 511826.14 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-153 IC50 167636.68 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-79 IC50 24493.43 nM 10.6019/CHEMBL1201861
Homo sapiens DnaJ homolog subfamily A member 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA polymerase kappa Potency 39810.7 nM None
Homo sapiens DNA replication licensing factor MCM4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA topoisomerase II alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA topoisomerase II beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DOHH-2 IC50 140767.56 nM 10.6019/CHEMBL1201861
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens dsDNA Delta Tm 0.1 degrees C 10.1016/j.bmc.2018.04.050
Homo sapiens DSH1 IC50 146690.07 nM 10.6019/CHEMBL1201861
Homo sapiens DU-145 Activity 1.113 None 10.1073/pnas.0707498104
Homo sapiens DU-145 GI 14.4 % 10.1016/j.ejmech.2018.10.062
Homo sapiens DU-145 GI50 18790.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens DU-4475 IC50 408806.12 nM 10.6019/CHEMBL1201861
Homo sapiens Dual serine/threonine and tyrosine protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Ki 3162.28 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Ki 3981.07 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Activity nan None 10.1021/acs.jmedchem.2c00671
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Activity nan None 10.1021/acs.jmedchem.2c00671
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Activity nan None 10.1021/acs.jmedchem.2c00671
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase CLK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase CLK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity protein kinase CLK2 Kd nan None 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK2 Ki 5011.87 nM None
Homo sapiens Dual specificity protein kinase CLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase CLK3 Kd nan None 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK4 Kd 2100.0 nM 10.1016/j.ejmech.2016.11.003
Homo sapiens Dual specificity protein kinase CLK4 Kd 2100.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK4 Kd 2100.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase CLK4 Kd 4200.0 nM 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK4 Ki 1258.93 nM None
Homo sapiens Dual specificity protein kinase TTK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase TTK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase TTK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity protein kinase TTK Kd nan None 10.1038/nbt1068
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Ki 3162.28 nM None
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Ki 2511.89 nM None
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Activity -10.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Inhibition -10.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Ki 6309.57 nM None
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 4 Ki 7943.28 nM None
Homo sapiens Dual specificty protein kinase CLK1 Kd 4500.0 nM 10.1038/nbt1068
Homo sapiens Dual specificty protein kinase CLK1 Kd 4500.0 nM 10.1038/nbt1358
Homo sapiens Dual specificty protein kinase CLK1 Kd 4500.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificty protein kinase CLK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dynamin-like 120 kDa protein, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens EB2 IC50 46698.96 nM 10.6019/CHEMBL1201861
Homo sapiens EB-3 IC50 322279.76 nM 10.6019/CHEMBL1201861
Homo sapiens ECC4 IC50 94255.48 nM 10.6019/CHEMBL1201861
Homo sapiens EC-GI-10 IC50 244739.41 nM 10.6019/CHEMBL1201861
Homo sapiens EFM-19 Activity 1.026 None 10.1073/pnas.0707498104
Homo sapiens EFO-21 Activity 0.991 None 10.1073/pnas.0707498104
Homo sapiens EGI-1 Activity 1.015 None 10.1073/pnas.0707498104
Homo sapiens EHEB IC50 348951.87 nM 10.6019/CHEMBL1201861
Homo sapiens EKVX GI50 26180.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens EKVX IC50 195094.1 nM 10.6019/CHEMBL1201861
Homo sapiens Electron transfer flavoprotein subunit beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Elongation factor Tu, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens EM-2 IC50 88.8 nM 10.6019/CHEMBL1201861
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens EOL1 GI50 0.5 nM 10.1016/j.ejmech.2019.111663
Homo sapiens EOL1 GI50 1.0 nM 10.1016/j.ejmech.2018.03.003
Homo sapiens EOL1 IC50 0.1995 nM 10.1021/jm800988r
Homo sapiens EOL1 IC50 0.2 nM 10.1021/jm800988r
Homo sapiens EOL1 IC50 81696.32 nM 10.6019/CHEMBL1201861
Homo sapiens EOL1 TGI 99.9 % 10.1016/j.ejmech.2018.03.003
Homo sapiens EOL1 TGI 100.0 % 10.1016/j.ejmech.2018.03.003
Homo sapiens Ephrin type-A receptor 1 Activity 22.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Ephrin type-A receptor 1 Inhibition 22.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Ephrin type-A receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 2 Ki 3162.28 nM None
Homo sapiens Ephrin type-A receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 4 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 5 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 6 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 7 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 8 Activity 7.2 % 10.1021/jm101396q
Homo sapiens Ephrin type-A receptor 8 Kd 1400.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 8 Kd 1400.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 8 Kd 2100.0 nM 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 1 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 4 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Epidermal growth factor receptor erbB1 Activity 13.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Epidermal growth factor receptor erbB1 IC50 0.11 nM 10.1016/j.ejmech.2022.114502
Homo sapiens Epidermal growth factor receptor erbB1 IC50 100000.0 nM 10.1016/S0960-894X(96)00601-4
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Epidermal growth factor receptor erbB1 Inhibition 9.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Epidermal growth factor receptor erbB1 Inhibition 13.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Epidermal growth factor receptor erbB1 Inhibition 14.0 % 10.1038/nchembio760
Homo sapiens Epidermal growth factor receptor erbB1 Kd 7600.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 7600.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Epidermal growth factor receptor erbB1 Kd nan None 10.1038/nbt1068
Homo sapiens Epidermal growth factor receptor erbB1 Ki 1995.26 nM None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Epithelial discoidin domain-containing receptor 1 Activity 0.2 % 10.1021/jm101396q
Homo sapiens Epithelial discoidin domain-containing receptor 1 GI50 3000.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens Epithelial discoidin domain-containing receptor 1 GI50 10000.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Epithelial discoidin domain-containing receptor 1 IC50 43.0 nM 10.1016/j.bmc.2010.08.026
Homo sapiens Epithelial discoidin domain-containing receptor 1 IC50 90.0 nM 10.1038/nrd.2016.266
Homo sapiens Epithelial discoidin domain-containing receptor 1 IC50 337.0 nM 10.1021/jm5012319
Homo sapiens Epithelial discoidin domain-containing receptor 1 IC50 31000.0 nM 10.1073/pnas.0707498104
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 0.7 nM 10.1038/nbt1358
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 0.7 nM 10.1038/nbt.1990
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 0.7943 nM 10.1021/acs.jmedchem.8b01925
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 22.0 nM 10.1126/science.aan4368
Homo sapiens EPLC-272H Activity 1.139 None 10.1073/pnas.0707498104
Homo sapiens ES1 IC50 27521.02 nM 10.6019/CHEMBL1201861
Homo sapiens ES3 IC50 208058.02 nM 10.6019/CHEMBL1201861
Homo sapiens ES4 IC50 52977.54 nM 10.6019/CHEMBL1201861
Homo sapiens ES5 IC50 67696.81 nM 10.6019/CHEMBL1201861
Homo sapiens ES6 IC50 113991.97 nM 10.6019/CHEMBL1201861
Homo sapiens ES7 IC50 14737.86 nM 10.6019/CHEMBL1201861
Homo sapiens ES8 IC50 144996.27 nM 10.6019/CHEMBL1201861
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens ETK-1 IC50 73493.21 nM 10.6019/CHEMBL1201861
Homo sapiens Eukaryotic peptide chain release factor GTP-binding subunit ERF3B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens EVSA-T Activity 1.301 None 10.1073/pnas.0707498104
Homo sapiens EVSA-T IC50 155309.2 nM 10.6019/CHEMBL1201861
Homo sapiens EW-1 IC50 32945.44 nM 10.6019/CHEMBL1201861
Homo sapiens EW-11 IC50 337787.16 nM 10.6019/CHEMBL1201861
Homo sapiens EW-12 IC50 272239.99 nM 10.6019/CHEMBL1201861
Homo sapiens EW-13 IC50 42279.11 nM 10.6019/CHEMBL1201861
Homo sapiens EW-16 IC50 136559.72 nM 10.6019/CHEMBL1201861
Homo sapiens EW-18 IC50 48439.47 nM 10.6019/CHEMBL1201861
Homo sapiens EW-22 IC50 74711.5 nM 10.6019/CHEMBL1201861
Homo sapiens EW-24 IC50 385718.57 nM 10.6019/CHEMBL1201861
Homo sapiens EW-3 IC50 202372.69 nM 10.6019/CHEMBL1201861
Homo sapiens Exosome RNA helicase MTR4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Eyes absent homolog 2 Potency 9530.0 nM None
Homo sapiens Ferrochelatase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Fibroblast growth factor receptor 1 Activity 80.0 % 10.1021/jm101396q
Homo sapiens Fibroblast growth factor receptor 1 Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Fibroblast growth factor receptor 1 Inhibition 1.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Fibroblast growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Fibroblast growth factor receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Fibroblast growth factor receptor 1 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 1 Ki 3981.07 nM None
Homo sapiens Fibroblast growth factor receptor 2 Activity 100.0 % 10.1021/jm101396q
Homo sapiens Fibroblast growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Fibroblast growth factor receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 3 Activity 97.0 % 10.1021/jm101396q
Homo sapiens Fibroblast growth factor receptor 3 Inhibition 27.0 % 10.1038/nchembio760
Homo sapiens Fibroblast growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Fibroblast growth factor receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 3 Ki 1995.26 nM None
Homo sapiens Fibroblast growth factor receptor 4 Activity 99.0 % 10.1021/jm101396q
Homo sapiens Fibroblast growth factor receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Flap endonuclease 1 Potency 35481.3 nM None
Homo sapiens Focal adhesion kinase 1 Inhibition -62.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Focal adhesion kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Focal adhesion kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Focal adhesion kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Focal adhesion kinase 1 Kd nan None 10.1038/nbt1068
Homo sapiens Focal adhesion kinase 1 Ki 5011.87 nM None
Homo sapiens FTC-133 Activity 0.967 None 10.1073/pnas.0707498104
Homo sapiens G-361 Activity 0.874 None 10.1073/pnas.0707498104
Homo sapiens G-361 FC nan None 10.1016/j.ejmech.2015.12.023
Homo sapiens G-401 Activity 0.951 None 10.1073/pnas.0707498104
Homo sapiens G-402 Activity 0.527 None 10.1073/pnas.0707498104
Homo sapiens GAK IC50 166790.91 nM 10.6019/CHEMBL1201861
Homo sapiens GAMG Activity 0.908 None 10.1073/pnas.0707498104
Homo sapiens GB-1 IC50 198293.65 nM 10.6019/CHEMBL1201861
Homo sapiens GCIY IC50 186553.68 nM 10.6019/CHEMBL1201861
Homo sapiens GCT Activity 1.013 None 10.1073/pnas.0707498104
Homo sapiens GDM-1 IC50 22594.49 nM 10.6019/CHEMBL1201861
Homo sapiens Geminin Potency 33498.3 nM None
Homo sapiens General transcription and DNA repair factor IIH helicase subunit XPD Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens GI-1 IC50 73286.76 nM 10.6019/CHEMBL1201861
Homo sapiens GI-ME-N IC50 87769.93 nM 10.6019/CHEMBL1201861
Homo sapiens GIST430 GI50 625.0 nM 10.1021/acs.jmedchem.9b01229
Homo sapiens GIST430 GI50 929.0 nM 10.1021/acs.jmedchem.8b01845
Homo sapiens GIST48 GI50 625.0 nM 10.1021/acs.jmedchem.8b01845
Homo sapiens GIST48 GI50 929.0 nM 10.1021/acs.jmedchem.9b01229
Homo sapiens GIST882 Activity nan None 10.1021/acs.jmedchem.6b01290
Homo sapiens GIST882 GI50 20.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens GIST882 GI50 58.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens GIST882 GI50 195.0 nM 10.1021/acs.jmedchem.8b01845
Homo sapiens GIST882 GI50 195.0 nM 10.1021/acs.jmedchem.9b01229
Homo sapiens GISTT1 Activity 1.54 g 10.1021/acs.jmedchem.9b00280
Homo sapiens GISTT1 Activity nan None 10.1021/acs.jmedchem.6b01290
Homo sapiens GISTT1 Activity nan None 10.1021/acs.jmedchem.9b00280
Homo sapiens GISTT1 GI50 3.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens GISTT1 GI50 26.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens GISTT1 GI50 40.0 nM 10.1021/acs.jmedchem.7b00841
Homo sapiens GISTT1 GI50 40.0 nM 10.1021/acs.jmedchem.9b01229
Homo sapiens GISTT1 GI50 10000.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens GISTT1 GI50 nan None 10.1021/acs.jmedchem.7b00841
Homo sapiens GISTT1 TGI 66.4 % 10.1021/acs.jmedchem.9b00280
Homo sapiens GISTT1 TGI 87.3 % 10.1021/acs.jmedchem.7b00468
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Glycine--tRNA ligase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 alpha Activity -1.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Glycogen synthase kinase-3 alpha Inhibition -1.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Glycogen synthase kinase-3 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Glycogen synthase kinase-3 alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Glycogen synthase kinase-3 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 alpha Ki 6309.57 nM None
Homo sapiens Glycogen synthase kinase-3 beta Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Glycogen synthase kinase-3 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Glycogen synthase kinase-3 beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Glycogen synthase kinase-3 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 beta Ki 5011.87 nM None
Homo sapiens GMS-10 Activity 0.962 None 10.1073/pnas.0707498104
Homo sapiens GOTO IC50 125674.47 nM 10.6019/CHEMBL1201861
Homo sapiens GP5d Activity 1.215 None 10.1073/pnas.0707498104
Homo sapiens G-protein coupled receptor kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens G protein-coupled receptor kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens G protein-coupled receptor kinase 5 Ki 3981.07 nM None
Homo sapiens G protein-coupled receptor kinase 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens GR-ST IC50 166650.53 nM 10.6019/CHEMBL1201861
Homo sapiens GT3TKB IC50 214498.77 nM 10.6019/CHEMBL1201861
Homo sapiens GTP-binding nuclear protein Ran Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Guanine nucleotide-binding protein G(i) subunit alpha-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens H4 Activity 0.82 None 10.1073/pnas.0707498104
Homo sapiens HAL-01 IC50 271317.58 nM 10.6019/CHEMBL1201861
Homo sapiens HC-1 IC50 511069.2 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1187 IC50 296495.19 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1395 Activity 0.979 None 10.1073/pnas.0707498104
Homo sapiens HCC1599 IC50 155366.68 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1806 Activity 1.1 None 10.1073/pnas.0707498104
Homo sapiens HCC1937 Activity 1.335 None 10.1073/pnas.0707498104
Homo sapiens HCC1954 Activity 0.947 None 10.1073/pnas.0707498104
Homo sapiens HCC2157 IC50 386149.27 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2218 IC50 86791.27 nM 10.6019/CHEMBL1201861
Homo sapiens HCC 2998 GI -22.0 % 10.1016/j.ejmech.2018.10.062
Homo sapiens HCC 2998 GI50 21230.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens HCC38 Activity 0.965 None 10.1073/pnas.0707498104
Homo sapiens HCC70 Activity 0.98 None 10.1073/pnas.0707498104
Homo sapiens HCC827 GI50 40000.0 nM 10.1016/j.ejmech.2019.111663
Homo sapiens HCE-4 IC50 91133.55 nM 10.6019/CHEMBL1201861
Homo sapiens HCE-T IC50 314476.39 nM 10.6019/CHEMBL1201861
Homo sapiens HCT-116 Activity 1.033 None 10.1073/pnas.0707498104
Homo sapiens HCT-116 Activity 60.0 % 10.1021/jm050705h
Homo sapiens HCT-116 GI 18.6 % 10.1016/j.ejmech.2018.10.062
Homo sapiens HCT-116 GI50 12590.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens HCT-116 IC50 10000.0 nM 10.1021/jm800988r
Homo sapiens HCT-116 IC50 19660.0 nM 10.1016/j.ejmech.2018.04.029
Homo sapiens HCT-116 IC50 34300.0 nM 10.1016/j.ejmech.2020.112946
Homo sapiens HCT-116 IC50 34400.0 nM 10.1016/j.ejmech.2015.08.018
Homo sapiens HCT-116 IC50 44550.0 nM 10.1016/j.ejmech.2018.12.012
Homo sapiens HCT-116 IC50 51210.0 nM 10.1016/j.ejmech.2018.12.012
Homo sapiens HCT-15 GI 11.5 % 10.1016/j.ejmech.2018.10.062
Homo sapiens HCT-15 GI50 19950.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens HCT-15 IC50 25000.0 nM 10.1021/jm800988r
Homo sapiens HCT-15 IC50 25118.86 nM 10.1021/jm800988r
Homo sapiens HCT-8 Activity 1.078 None 10.1073/pnas.0707498104
Homo sapiens HDLM-2 IC50 346752.41 nM 10.6019/CHEMBL1201861
Homo sapiens HD-MY-Z IC50 437372.83 nM 10.6019/CHEMBL1201861
Homo sapiens HEK293 CC50 8400.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens HEK293 CC50 20000.0 nM 10.6019/CHEMBL4513161
Homo sapiens HEK293 IC50 10000.0 nM 10.1021/acs.jmedchem.1c01853
Homo sapiens HEK-293T CC50 27540.0 nM 10.1016/j.bmcl.2016.10.007
Homo sapiens HEL GI50 5300.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens HEL IC50 481008.05 nM 10.6019/CHEMBL1201861
Homo sapiens HeLa Activity 0.994 None 10.1073/pnas.0707498104
Homo sapiens HeLa Activity 1.064 None 10.1073/pnas.0707498104
Homo sapiens HeLa Activity 1.073 None 10.1073/pnas.0707498104
Homo sapiens HeLa Activity 1.086 None 10.1073/pnas.0707498104
Homo sapiens HeLa Activity 1.179 None 10.1073/pnas.0707498104
Homo sapiens HeLa Activity 1.246 None 10.1073/pnas.0707498104
Homo sapiens HeLa CC50 10.0 ug.mL-1 10.1021/np500538c
Homo sapiens HeLa CC50 38.8 ug.mL-1 10.1016/j.bmc.2010.01.053
Homo sapiens HeLa CC50 65800.0 nM 10.1021/np2008544
Homo sapiens HeLa IC50 18650.0 nM 10.1021/jm800988r
Homo sapiens HeLa IC50 25118.86 nM 10.1021/jm800988r
Homo sapiens Heme oxygenase 1 Inhibition nan % 10.1016/j.ejmech.2018.09.048
Homo sapiens Heme oxygenase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Hepatocyte growth factor receptor Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Hepatocyte growth factor receptor Inhibition 10.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Hepatocyte growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Hepatocyte growth factor receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Hepatocyte growth factor receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Hepatocyte growth factor receptor Ki 2511.89 nM None
Homo sapiens HepG2 Activity 13.0 % 10.1021/jm501177w
Homo sapiens HepG2 Activity 72.0 % 10.1021/jm501177w
Homo sapiens HepG2 Activity 75.0 % 10.1021/jm501177w
Homo sapiens HepG2 IC50 10000.0 nM 10.1016/j.bmc.2013.07.026
Homo sapiens HepG2 IC50 25000.0 nM 10.1016/j.bmc.2015.12.011
Homo sapiens HepG2 IC50 nan None 10.1016/j.bmc.2013.05.008
Homo sapiens HepG2 IC50 nan None 10.1016/j.bmc.2013.07.026
Homo sapiens HepG2 IC50 nan None 10.1016/j.bmc.2015.02.036
Homo sapiens HepG2 IC50 relative 7300.0 nM 10.6019/EOS300108
Homo sapiens HepG2 Potency 316.2 nM None
Homo sapiens HepG2 Potency 25118.9 nM None
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens HGC-27 Activity 0.946 None 10.1073/pnas.0707498104
Homo sapiens HGC-27 IC50 2400.0 nM 10.1016/j.bmc.2018.04.050
Homo sapiens HGC-27 IC50 2400.0 nM 10.1021/jm900424a
Homo sapiens HGC-27 IC50 3800.0 nM 10.1021/ml400271y
Homo sapiens HH IC50 17399.87 nM 10.6019/CHEMBL1201861
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 1963.0 nM None
Homo sapiens Histamine H2 receptor Ki 1930.0 nM None
Homo sapiens Histone deacetylase EC50 100000.0 nM 10.1021/jm800988r
Homo sapiens Histone deacetylase 1 IC50 100000.0 nM 10.1021/jm800988r
Homo sapiens Histone deacetylase 6 IC50 100000.0 nM 10.1021/jm800988r
Homo sapiens Histone deacetylase 6 Inhibition 7.28 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 36.27 % 10.6019/CHEMBL4808148
Homo sapiens HL-60 GI50 10000.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens HL-60 IC50 10000.0 nM 10.1038/nchembio760
Homo sapiens HL-60 IC50 17200.0 nM 10.1016/j.bmcl.2023.129144
Homo sapiens HL-60 IC50 28540.0 nM 10.1016/j.ejmech.2022.114731
Homo sapiens HL-60 IC50 55000.0 nM 10.1016/j.ejmech.2014.03.054
Homo sapiens HL-60 IC50 471164.36 nM 10.6019/CHEMBL1201861
Homo sapiens HL-60(TB) GI -6.8 % 10.1016/j.ejmech.2018.10.062
Homo sapiens HL-60(TB) GI nan None 10.1016/j.ejmech.2020.112710
Homo sapiens HL-60(TB) GI50 13490.0 nM 10.1016/j.ejmech.2020.112710
Homo sapiens HL-60(TB) GI50 13490.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens HLE Activity 1.0 None 10.1073/pnas.0707498104
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homeodomain-interacting protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Homeodomain-interacting protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Homeodomain-interacting protein kinase 2 Ki 3162.28 nM None
Homo sapiens Homeodomain-interacting protein kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Homeodomain-interacting protein kinase 4 Kd 960.0 nM 10.1038/nbt.1990
Homo sapiens Homeodomain-interacting protein kinase 4 Ki 7943.28 nM None
Homo sapiens Homo sapiens Activity nan None 10.1002/hep.27206
Homo sapiens Homo sapiens Activity nan None 10.1016/j.bmc.2010.08.026
Homo sapiens Homo sapiens AUC 52200.32 ng.hr.mL-1 10.1093/toxsci/kft176
Homo sapiens Homo sapiens CL 3.3 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens CL 70.0 % 10.1021/jm300065h
Homo sapiens Homo sapiens CL_renal 0.13 mL.min-1.kg-1 10.1021/jm900403j
Homo sapiens Homo sapiens Cmax 2000.0 nM 10.1038/nchembio0309-144
Homo sapiens Homo sapiens Cmax 3650.0 nM 10.1021/jm301302s
Homo sapiens Homo sapiens Cmax 7090.0 nM 10.1002/hep.27206
Homo sapiens Homo sapiens Css 4.406 uM 10.1093/toxsci/kft176
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 8.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Fabs 67.0 % 10.1124/dmd.110.034629
Homo sapiens Homo sapiens Inhibition 10.0 % 10.1021/jm300065h
Homo sapiens Homo sapiens MTD 400.0 mg 10.1016/j.bmc.2010.08.026
Homo sapiens HOP-62 GI nan None 10.1016/j.ejmech.2018.10.062
Homo sapiens HOP-62 GI50 21530.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens HOP-62 IC50 187197.84 nM 10.6019/CHEMBL1201861
Homo sapiens HOP-92 Activity 1.096 None 10.1073/pnas.0707498104
Homo sapiens HOP-92 GI 43.7 % 10.1016/j.ejmech.2018.10.062
Homo sapiens HOP-92 GI50 13340.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens Hormonally up-regulated neu tumor-associated kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens HOS Activity 0.79 None 10.1073/pnas.0707498104
Homo sapiens HOS-TE85 Activity nan None 10.1021/acs.jmedchem.1c01732
Homo sapiens HOS-TE85 IC50 20500.0 nM 10.1021/acs.jmedchem.1c01732
Homo sapiens HPAC Activity 1.09 None 10.1073/pnas.0707498104
Homo sapiens HPAF-II Activity 1.388 None 10.1073/pnas.0707498104
Homo sapiens Hs-578T GI 9.9 % 10.1016/j.ejmech.2018.10.062
Homo sapiens Hs-578T GI50 14590.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens Hs 683 Activity 1.055 None 10.1073/pnas.0707498104
Homo sapiens HT IC50 454886.53 nM 10.6019/CHEMBL1201861
Homo sapiens HT-1080 Activity 0.997 None 10.1073/pnas.0707498104
Homo sapiens HT-144 IC50 41548.61 nM 10.6019/CHEMBL1201861
Homo sapiens HT-29 Activity 1.049 None 10.1073/pnas.0707498104
Homo sapiens HT-29 GI 47.1 % 10.1016/j.ejmech.2018.10.062
Homo sapiens HT-29 GI50 3970.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens HT-29 IC50 60.0 nM 10.1016/j.bmc.2018.04.050
Homo sapiens HT-29 IC50 60.0 nM 10.1021/jm900424a
Homo sapiens HT-3 Activity 0.899 None 10.1073/pnas.0707498104
Homo sapiens HTC-C3 Activity 1.151 None 10.1073/pnas.0707498104
Homo sapiens HuP-T3 Activity 1.044 None 10.1073/pnas.0707498104
Homo sapiens HuP-T4 Activity 1.094 None 10.1073/pnas.0707498104
Homo sapiens HuTu80 IC50 172814.02 nM 10.6019/CHEMBL1201861
Homo sapiens HUVEC GI50 10.0 ug.mL-1 10.1021/np500538c
Homo sapiens HUVEC GI50 10.9 ug.mL-1 10.1016/j.bmc.2010.01.053
Homo sapiens HUVEC GI50 18500.0 nM 10.1021/np2008544
Homo sapiens IA-LM IC50 145139.3 nM 10.6019/CHEMBL1201861
Homo sapiens IGR-1 Activity 1.046 None 10.1073/pnas.0707498104
Homo sapiens IGROV-1 Activity 0.989 None 10.1073/pnas.0707498104
Homo sapiens IGROV-1 GI -18.6 % 10.1016/j.ejmech.2018.10.062
Homo sapiens IGROV-1 GI50 21180.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens IM-9 IC50 311071.57 nM 10.6019/CHEMBL1201861
Homo sapiens IMR-5 IC50 6221.47 nM 10.6019/CHEMBL1201861
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Ki 3981.07 nM None
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Inhibition 3.0 % 10.1038/nchembio760
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Ki 3162.28 nM None
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Ki 3162.28 nM None
Homo sapiens Inosine-5'-monophosphate dehydrogenase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin-like growth factor I receptor Inhibition 17.0 % 10.1038/nchembio760
Homo sapiens Insulin-like growth factor I receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin-like growth factor I receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Insulin-like growth factor I receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin-like growth factor I receptor Ki 1995.26 nM None
Homo sapiens Insulin receptor Inhibition 2.0 % 10.1038/nchembio760
Homo sapiens Insulin receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Insulin receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin receptor Kd nan None 10.1038/nbt1068
Homo sapiens Insulin receptor Ki 5011.87 nM None
Homo sapiens Insulin receptor-related protein Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin receptor-related protein Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Interleukin-1 receptor-associated kinase 1 Kd 1200.0 nM 10.1038/nbt.1990
Homo sapiens Interleukin-1 receptor-associated kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 1 Ki 7943.28 nM None
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Interleukin-1 receptor-associated kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 4 Ki 10000.0 nM None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens IPC-298 Activity 1.101 None 10.1073/pnas.0707498104
Homo sapiens Ishikawa Activity 1.031 None 10.1073/pnas.0707498104
Homo sapiens Ishikawa Activity 1.049 None 10.1073/pnas.0707498104
Homo sapiens IST-MEL1 IC50 82348.23 nM 10.6019/CHEMBL1201861
Homo sapiens IST-MES1 IC50 182208.93 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL1 IC50 125709.04 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL2 IC50 169933.64 nM 10.6019/CHEMBL1201861
Homo sapiens J82 Activity 0.958 None 10.1073/pnas.0707498104
Homo sapiens JAR IC50 383537.35 nM 10.6019/CHEMBL1201861
Homo sapiens JIYOYE IC50 371473.3 nM 10.6019/CHEMBL1201861
Homo sapiens J-RT3-T3-5 IC50 329220.59 nM 10.6019/CHEMBL1201861
Homo sapiens Jurkat IC50 1000.0 nM 10.1021/acs.jmedchem.1c00082
Homo sapiens Jurkat IC50 10000.0 nM 10.1038/nchembio760
Homo sapiens JVM-2 IC50 103630.43 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-3 IC50 337549.11 nM 10.6019/CHEMBL1201861
Homo sapiens K052 IC50 596028.21 nM 10.6019/CHEMBL1201861
Homo sapiens K5 IC50 183924.07 nM 10.6019/CHEMBL1201861
Homo sapiens K562 AC50 680.0 nM 10.1016/j.ejmech.2015.11.022
Homo sapiens K562 Activity 0.2 % 10.1016/j.bmcl.2023.129144
Homo sapiens K562 Activity 0.5 % 10.1021/acs.jmedchem.1c00246
Homo sapiens K562 Activity 1.9 % 10.1021/acs.jmedchem.1c00246
Homo sapiens K562 Activity 4.9 % 10.1016/j.bmcl.2023.129144
Homo sapiens K562 Activity 9.7 % 10.1021/acs.jmedchem.6b00547
Homo sapiens K562 Activity 16.0 % 10.1021/acs.jmedchem.1c00246
Homo sapiens K562 Activity 17.0 % 10.1016/j.ejmech.2020.112258
Homo sapiens K562 Activity 18.2 % 10.1016/j.bmcl.2023.129144
Homo sapiens K562 Activity 23.1 % 10.1016/j.bmcl.2023.129144
Homo sapiens K562 Activity 46.0 % 10.1016/j.ejmech.2020.112258
Homo sapiens K562 Activity 51.2 % 10.1016/j.ejmech.2017.02.051
Homo sapiens K562 Activity 66.7 % 10.1021/jm0602716
Homo sapiens K562 Activity 70.0 % 10.1021/jm0602716
Homo sapiens K562 Activity 71.0 % 10.1021/jm0602716
Homo sapiens K562 Activity 71.2 % 10.1021/jm0602716
Homo sapiens K562 Activity 76.7 % 10.1016/j.bmcl.2023.129144
Homo sapiens K562 Activity 81.6 % 10.1021/acs.jmedchem.1c00246
Homo sapiens K562 Activity 85.5 % 10.1021/acs.jmedchem.6b00547
Homo sapiens K562 Activity nan None 10.1016/j.bmcl.2019.05.005
Homo sapiens K562 Activity nan None 10.1021/acs.jmedchem.6b01290
Homo sapiens K562 Activity nan None 10.1021/jm301581y
Homo sapiens K562 GI 71.0 % 10.1016/j.bmcl.2020.127561
Homo sapiens K562 GI 71.0 % 10.1021/acs.jmedchem.6b01745
Homo sapiens K562 GI nan None 10.1016/j.ejmech.2018.10.062
Homo sapiens K562 GI nan None 10.1016/j.ejmech.2020.112710
Homo sapiens K562 GI50 0.0001 ug.mL-1 10.1016/j.bmc.2010.01.053
Homo sapiens K562 GI50 0.1 ug.mL-1 10.1021/np500538c
Homo sapiens K562 GI50 20.0 nM 10.1016/j.ejmech.2020.112710
Homo sapiens K562 GI50 20.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens K562 GI50 120.0 nM 10.1021/acs.jmedchem.6b00200
Homo sapiens K562 GI50 140.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens K562 GI50 147.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens K562 GI50 170.0 nM 10.1021/np2008544
Homo sapiens K562 GI50 200.0 nM 10.1021/acs.jmedchem.5b01712
Homo sapiens K562 GI50 250.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens K562 GI50 390.0 nM 10.1016/j.bmcl.2012.08.014
Homo sapiens K562 GI50 563.0 nM 10.1021/acs.jmedchem.1c01853
Homo sapiens K562 GI50 730.0 nM 10.1016/j.ejmech.2019.111663
Homo sapiens K562 GI50 800.0 nM 10.1016/j.ejmech.2020.112710
Homo sapiens K562 GI50 10000.0 nM 10.1021/acs.jmedchem.1c01853
Homo sapiens K562 IC50 0.15 nM 10.1016/j.ejmech.2018.12.040
Homo sapiens K562 IC50 6.05 nM 10.1016/j.bmcl.2011.02.029
Homo sapiens K562 IC50 49.0 nM 10.1021/jm800988r
Homo sapiens K562 IC50 60.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens K562 IC50 76.2 nM 10.1021/acs.jmedchem.0c00967
Homo sapiens K562 IC50 82.9 nM 10.1021/acs.jmedchem.1c00082
Homo sapiens K562 IC50 100.0 nM 10.1016/j.bmcl.2012.04.109
Homo sapiens K562 IC50 100.0 nM 10.1021/jm800988r
Homo sapiens K562 IC50 109.0 nM 10.1038/nchembio760
Homo sapiens K562 IC50 110.0 nM 10.1016/s0960-894x(03)00553-5
Homo sapiens K562 IC50 135.0 nM 10.1016/j.ejmech.2022.114731
Homo sapiens K562 IC50 140.0 nM 10.1016/j.bmcl.2019.05.005
Homo sapiens K562 IC50 170.0 nM 10.1021/jm301891t
Homo sapiens K562 IC50 180.0 nM 10.1016/j.bmcl.2007.05.067
Homo sapiens K562 IC50 182.0 nM 10.1016/j.bmcl.2005.11.042
Homo sapiens K562 IC50 220.0 nM 10.1016/j.ejmech.2015.11.022
Homo sapiens K562 IC50 224.32 nM 10.6019/CHEMBL1201861
Homo sapiens K562 IC50 244.0 nM 10.1016/j.bmc.2010.08.026
Homo sapiens K562 IC50 280.0 nM 10.1016/j.bmcl.2015.07.006
Homo sapiens K562 IC50 380.0 nM 10.1016/j.bmcl.2011.02.029
Homo sapiens K562 IC50 380.0 nM 10.1016/j.bmcl.2016.01.068
Homo sapiens K562 IC50 384.4 nM 10.1016/j.bmcl.2012.06.044
Homo sapiens K562 IC50 400.0 nM 10.1016/j.bmcl.2003.08.014
Homo sapiens K562 IC50 470.0 nM 10.1016/j.bmc.2013.05.008
Homo sapiens K562 IC50 470.0 nM 10.1016/j.bmc.2015.02.036
Homo sapiens K562 IC50 500.0 nM 10.1016/j.bmc.2013.01.004
Homo sapiens K562 IC50 500.0 nM 10.1016/j.bmc.2013.07.026
Homo sapiens K562 IC50 500.0 nM 10.1016/j.bmc.2015.02.026
Homo sapiens K562 IC50 500.0 nM 10.1016/j.bmcl.2016.05.004
Homo sapiens K562 IC50 500.0 nM 10.1016/j.ejmech.2013.08.009
Homo sapiens K562 IC50 510.0 nM 10.1021/acs.jmedchem.5b01841
Homo sapiens K562 IC50 530.0 nM 10.1016/j.bmc.2015.12.011
Homo sapiens K562 IC50 530.0 nM 10.1016/j.ejmech.2017.05.006
Homo sapiens K562 IC50 580.0 nM 10.1016/j.ejmech.2011.01.020
Homo sapiens K562 IC50 610.0 nM 10.1016/j.bmcl.2020.127638
Homo sapiens K562 IC50 730.0 nM 10.1016/j.ejmech.2015.12.023
Homo sapiens K562 IC50 1000.0 nM 10.1016/j.ejmech.2018.09.048
Homo sapiens K562 IC50 1100.0 nM 10.1016/j.bmcl.2018.03.063
Homo sapiens K562 IC50 1100.0 nM 10.1016/j.ejmech.2022.114425
Homo sapiens K562 IC50 1160.0 nM 10.1016/j.ejmech.2015.07.015
Homo sapiens K562 IC50 1160.0 nM 10.1016/j.ejmech.2015.09.034
Homo sapiens K562 IC50 3430.0 nM 10.1016/j.ejmech.2018.04.029
Homo sapiens K562 IC50 4120.0 nM 10.1016/j.bmc.2014.10.030
Homo sapiens K562 IC50 4120.0 nM 10.1016/j.bmcl.2015.08.013
Homo sapiens K562 IC50 4260.0 nM 10.1016/j.bmc.2021.116398
Homo sapiens K562 IC50 4260.0 nM 10.1016/j.ejmech.2019.05.091
Homo sapiens K562 IC50 4630.0 nM 10.1016/j.bmcl.2021.128116
Homo sapiens K562 IC50 5400.0 nM 10.1016/j.bmc.2011.04.053
Homo sapiens K562 IC50 7380.0 nM 10.1016/j.bmcl.2016.10.007
Homo sapiens K562 IC50 13000.0 nM 10.1016/j.ejmech.2014.03.054
Homo sapiens K562 IC50 13970.0 nM 10.1016/j.bmcl.2023.129144
Homo sapiens K562 IC50 15700.0 nM 10.1016/j.ejmech.2015.07.015
Homo sapiens K562 IC50 87320.0 nM 10.1021/acs.jmedchem.1c00246
Homo sapiens K562 Inhibition nan % 10.1016/j.ejmech.2014.03.054
Homo sapiens K562 Ratio IC50 9.1 None 10.1021/acs.jmedchem.5b01841
Homo sapiens K562 Ratio IC50 18.0 None 10.1016/j.bmcl.2015.07.065
Homo sapiens K562 TGI 57.0 % 10.1021/acs.jmedchem.5b01712
Homo sapiens K562/A02 IC50 980.0 nM 10.1016/j.bmcl.2020.127638
Homo sapiens K562/A02 IC50 75690.0 nM 10.1021/acs.jmedchem.1c00246
Homo sapiens K562/Adr IC50 13470.0 nM 10.1016/j.ejmech.2022.114425
Homo sapiens K-562R Activity 0.79 % 10.1016/j.ejmech.2018.09.048
Homo sapiens K-562R Activity 3.6 % 10.1016/j.ejmech.2018.09.048
Homo sapiens K-562R Activity 6.25 % 10.1016/j.ejmech.2018.09.048
Homo sapiens K-562R Activity 89.38 % 10.1016/j.ejmech.2018.09.048
Homo sapiens K-562R Activity nan None 10.1016/j.ejmech.2018.09.048
Homo sapiens K-562R IC50 50000.0 nM 10.1016/j.bmcl.2018.03.063
Homo sapiens K-562R IC50 90000.0 nM 10.1016/j.ejmech.2019.05.091
Homo sapiens K-562R IC50 93010.0 nM 10.1016/j.ejmech.2022.114425
Homo sapiens K-562R IC50 98820.0 nM 10.1016/j.ejmech.2018.09.048
Homo sapiens K-562R Inhibition 45.0 % 10.1016/j.bmc.2021.116398
Homo sapiens KALS-1 IC50 43132.85 nM 10.6019/CHEMBL1201861
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens KARPAS-299 IC50 563635.63 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-422 IC50 202508.93 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-45 IC50 18184.83 nM 10.6019/CHEMBL1201861
Homo sapiens Kasumi 1 IC50 545617.95 nM 10.6019/CHEMBL1201861
Homo sapiens KE-37 IC50 156467.92 nM 10.6019/CHEMBL1201861
Homo sapiens KG-1 IC50 210100.29 nM 10.6019/CHEMBL1201861
Homo sapiens KGN IC50 202038.85 nM 10.6019/CHEMBL1201861
Homo sapiens KINGS-1 IC50 86161.81 nM 10.6019/CHEMBL1201861
Homo sapiens KLE IC50 102503.2 nM 10.6019/CHEMBL1201861
Homo sapiens KM12 GI -6.7 % 10.1016/j.ejmech.2018.10.062
Homo sapiens KM12 GI50 18840.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens KM12 IC50 171110.75 nM 10.6019/CHEMBL1201861
Homo sapiens KM-H2 Activity 0.996 None 10.1073/pnas.0707498104
Homo sapiens KM-H2 IC50 425344.32 nM 10.6019/CHEMBL1201861
Homo sapiens KMOE-2 IC50 345555.06 nM 10.6019/CHEMBL1201861
Homo sapiens KMS-12-PE IC50 237106.64 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-42 IC50 89101.84 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-81-FD IC50 180897.58 nM 10.6019/CHEMBL1201861
Homo sapiens KP-4 Activity 1.009 None 10.1073/pnas.0707498104
Homo sapiens KP-N-RT-BM-1 IC50 66636.6 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-YS IC50 72713.93 nM 10.6019/CHEMBL1201861
Homo sapiens KS-1 IC50 147443.49 nM 10.6019/CHEMBL1201861
Homo sapiens KU-19-19 Activity 0.996 None 10.1073/pnas.0707498104
Homo sapiens KU812 cell line Activity nan None 10.1021/acs.jmedchem.6b01290
Homo sapiens KU812 cell line GI50 110.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens KU812 cell line GI50 310.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens KU812 cell line IC50 51.3 nM 10.1021/acs.jmedchem.1c00082
Homo sapiens KU812 cell line IC50 111186.61 nM 10.6019/CHEMBL1201861
Homo sapiens KURAMOCHI IC50 167789.97 nM 10.6019/CHEMBL1201861
Homo sapiens KY821 IC50 64255.16 nM 10.6019/CHEMBL1201861
Homo sapiens KYSE-140 Activity 1.026 None 10.1073/pnas.0707498104
Homo sapiens KYSE-180 Activity 1.057 None 10.1073/pnas.0707498104
Homo sapiens KYSE-270 Activity 1.002 None 10.1073/pnas.0707498104
Homo sapiens KYSE-410 Activity 1.015 None 10.1073/pnas.0707498104
Homo sapiens KYSE-450 Activity 1.185 None 10.1073/pnas.0707498104
Homo sapiens KYSE-510 Activity 0.965 None 10.1073/pnas.0707498104
Homo sapiens L02 IC50 100000.0 nM 10.1016/j.bmcl.2021.128116
Homo sapiens L132 GI50 10000.0 nM 10.1016/j.ejmech.2020.112710
Homo sapiens L-363 IC50 468783.95 nM 10.6019/CHEMBL1201861
Homo sapiens L-428 IC50 434899.51 nM 10.6019/CHEMBL1201861
Homo sapiens L-540 IC50 26914.28 nM 10.6019/CHEMBL1201861
Homo sapiens LAMA-84 IC50 73.04 nM 10.6019/CHEMBL1201861
Homo sapiens LAN-6 IC50 536721.86 nM 10.6019/CHEMBL1201861
Homo sapiens LB1047-RCC IC50 18445.22 nM 10.6019/CHEMBL1201861
Homo sapiens LB2241-RCC IC50 8073.84 nM 10.6019/CHEMBL1201861
Homo sapiens LB2518-MEL IC50 16609.4 nM 10.6019/CHEMBL1201861
Homo sapiens LB373-MEL-D IC50 121620.19 nM 10.6019/CHEMBL1201861
Homo sapiens LB647-SCLC IC50 64118.82 nM 10.6019/CHEMBL1201861
Homo sapiens LB771-HNC IC50 201683.57 nM 10.6019/CHEMBL1201861
Homo sapiens LB831-BLC IC50 117025.05 nM 10.6019/CHEMBL1201861
Homo sapiens LB996-RCC IC50 243229.39 nM 10.6019/CHEMBL1201861
Homo sapiens LC-1F IC50 242283.37 nM 10.6019/CHEMBL1201861
Homo sapiens LC-2-ad IC50 65760.08 nM 10.6019/CHEMBL1201861
Homo sapiens LC4-1 IC50 18065.19 nM 10.6019/CHEMBL1201861
Homo sapiens LCLC-97TM1 Activity 0.958 None 10.1073/pnas.0707498104
Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Ki 2511.89 nM None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Leukocyte tyrosine kinase receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Leukocyte tyrosine kinase receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Leukocyte tyrosine kinase receptor Ki 2511.89 nM None
Homo sapiens LIM domain kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens LIM domain kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens LIM domain kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens LIM domain kinase 1 Kd nan None 10.1038/nbt1068
Homo sapiens LIM domain kinase 1 Ki 2511.89 nM None
Homo sapiens LIM domain kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens LIM domain kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens LIM domain kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Liver glycogen phosphorylase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Liver microsomes CL 66.4 mL.min-1.g-1 10.1016/j.bmc.2013.03.038
Homo sapiens Liver microsomes Drug metabolism 0.2 % 10.1016/j.bmc.2013.03.038
Homo sapiens Liver microsomes Drug metabolism 22.6 % 10.1016/j.bmc.2013.03.038
Homo sapiens Liver microsomes Stability 67.3 % 10.1016/j.bmc.2013.03.038
Homo sapiens Liver microsomes T1/2 0.35 hr 10.1016/j.bmc.2013.03.038
Homo sapiens LK-2 Activity 0.899 None 10.1073/pnas.0707498104
Homo sapiens LN-405 Activity 0.876 None 10.1073/pnas.0707498104
Homo sapiens LNCaP-Clone-FGC IC50 113446.91 nM 10.6019/CHEMBL1201861
Homo sapiens Long-chain-fatty-acid--CoA ligase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens LOUCY IC50 368032.78 nM 10.6019/CHEMBL1201861
Homo sapiens LoVo Activity 1.087 None 10.1073/pnas.0707498104
Homo sapiens LOX IMVI GI 11.6 % 10.1016/j.ejmech.2018.10.062
Homo sapiens LOX IMVI GI50 18110.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens LOX IMVI IC50 117116.25 nM 10.6019/CHEMBL1201861
Homo sapiens LP-1 IC50 551930.98 nM 10.6019/CHEMBL1201861
Homo sapiens LS-1034 IC50 214692.12 nM 10.6019/CHEMBL1201861
Homo sapiens LS-123 IC50 259843.62 nM 10.6019/CHEMBL1201861
Homo sapiens LS174T Activity 0.989 None 10.1073/pnas.0707498104
Homo sapiens LS-411N IC50 175561.6 nM 10.6019/CHEMBL1201861
Homo sapiens LS-513 IC50 26884.66 nM 10.6019/CHEMBL1201861
Homo sapiens LU-134-A IC50 103238.41 nM 10.6019/CHEMBL1201861
Homo sapiens LU-135 Activity 1.014 None 10.1073/pnas.0707498104
Homo sapiens LU-139 IC50 222229.36 nM 10.6019/CHEMBL1201861
Homo sapiens LU-165 IC50 223515.78 nM 10.6019/CHEMBL1201861
Homo sapiens Lu-65 IC50 233456.79 nM 10.6019/CHEMBL1201861
Homo sapiens LU-99A Activity 1.107 None 10.1073/pnas.0707498104
Homo sapiens LXF-289 cell line IC50 73728.98 nM 10.6019/CHEMBL1201861
Homo sapiens Lysyl-tRNA synthetase Kd 3162.28 nM 10.1021/acs.jmedchem.8b01925
Homo sapiens M059J Activity 1.038 None 10.1073/pnas.0707498104
Homo sapiens M14 Activity 0.908 None 10.1073/pnas.0707498104
Homo sapiens M14 GI50 19280.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens Macrophage colony stimulating factor receptor Activity 0.0 % 10.1021/jm101396q
Homo sapiens Macrophage colony stimulating factor receptor Activity 2.0 % 10.1016/j.bmc.2010.01.056
Homo sapiens Macrophage colony stimulating factor receptor Activity 52.0 % 10.1016/j.bmc.2010.01.056
Homo sapiens Macrophage colony stimulating factor receptor Activity 92.0 % 10.1016/j.bmc.2010.01.056
Homo sapiens Macrophage colony stimulating factor receptor GI50 110.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Macrophage colony stimulating factor receptor IC50 291.0 nM 10.1016/j.bmc.2010.08.026
Homo sapiens Macrophage colony stimulating factor receptor IC50 960.0 nM 10.1021/jm020143r
Homo sapiens Macrophage colony stimulating factor receptor IC50 1274.0 nM 10.1016/j.bmc.2010.01.056
Homo sapiens Macrophage colony stimulating factor receptor Inhibition nan % 10.1016/j.bmc.2010.01.056
Homo sapiens Macrophage colony stimulating factor receptor Kd 10.0 nM 10.1021/acs.jmedchem.8b01925
Homo sapiens Macrophage colony stimulating factor receptor Kd 11.0 nM 10.1038/nbt.1990
Homo sapiens Macrophage colony stimulating factor receptor Kd 19.0 nM 10.1038/nbt1358
Homo sapiens Macrophage colony stimulating factor receptor Ki 158.49 nM None
Homo sapiens Macrophage colony stimulating factor receptor logIC50 3.1 None 10.1016/j.bmc.2010.01.056
Homo sapiens Macrophage-stimulating protein receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Macrophage-stimulating protein receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Macrophage-stimulating protein receptor Ki 3981.07 nM None
Homo sapiens Malme-3M GI -13.7 % 10.1016/j.ejmech.2018.10.062
Homo sapiens Malme-3M GI50 16330.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens MAP kinase-activated protein kinase 2 Inhibition 19.0 % 10.1038/nchembio760
Homo sapiens MAP kinase-activated protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase-activated protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase-activated protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 2 Ki 7943.28 nM None
Homo sapiens MAP kinase-activated protein kinase 3 Ki 10000.0 nM None
Homo sapiens MAP kinase-activated protein kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase-activated protein kinase 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase-activated protein kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 5 Ki 1584.89 nM None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Inhibition -2.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens MAP kinase ERK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase ERK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase ERK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Inhibition 4.0 % 10.1038/nchembio760
Homo sapiens MAP kinase ERK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase ERK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase ERK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase ERK2 Ki 7943.28 nM None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 IC50 70000.0 nM 10.1016/j.ejmech.2017.10.061
Homo sapiens MAP kinase p38 alpha Activity 4.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens MAP kinase p38 alpha Activity 17.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens MAP kinase p38 alpha Activity nan None 10.1021/acs.jmedchem.2c00671
Homo sapiens MAP kinase p38 alpha IC50 13700.0 nM 10.1016/j.bmcl.2008.05.089
Homo sapiens MAP kinase p38 alpha IC50 100000.0 nM 10.1016/j.bmc.2010.05.063
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Inhibition 13.0 % 10.1038/nchembio760
Homo sapiens MAP kinase p38 alpha Inhibition 17.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens MAP kinase p38 alpha Kd 3162.28 nM 10.1021/acs.jmedchem.8b01925
Homo sapiens MAP kinase p38 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase p38 alpha Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase p38 alpha Ki 3981.07 nM None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens MAP kinase p38 alpha Tm 49.1 degrees C 10.1021/acs.jmedchem.2c00671
Homo sapiens MAP kinase p38 alpha Tm 50.8 degrees C 10.1021/acs.jmedchem.2c00671
Homo sapiens MAP kinase p38 beta Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens MAP kinase p38 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase p38 beta Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase p38 delta Inhibition 14.0 % 10.1038/nchembio760
Homo sapiens MAP kinase p38 delta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 delta Ki 7943.28 nM None
Homo sapiens MAP kinase p38 gamma Inhibition 7.0 % 10.1038/nchembio760
Homo sapiens MAP kinase p38 gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 gamma Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase p38 gamma Ki 6309.57 nM None
Homo sapiens MAP kinase signal-integrating kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase signal-integrating kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase signal-integrating kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase signal-integrating kinase 2 Ki 10000.0 nM None
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Activity 8.8 % 10.1021/jm101396q
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Ki 7943.28 nM None
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Ki 5011.87 nM None
Homo sapiens Maternal embryonic leucine zipper kinase Kd 1900.0 nM 10.1038/nbt1358
Homo sapiens Maternal embryonic leucine zipper kinase Kd 1900.0 nM 10.1038/nbt.1990
Homo sapiens Maternal embryonic leucine zipper kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Maternal embryonic leucine zipper kinase Ki 1258.93 nM None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MC116 IC50 240614.72 nM 10.6019/CHEMBL1201861
Homo sapiens MC-CAR IC50 320544.46 nM 10.6019/CHEMBL1201861
Homo sapiens MCF-10A IC50 100000.0 nM 10.1016/j.ejmech.2019.02.033
Homo sapiens MCF7 Activity 0.919 None 10.1073/pnas.0707498104
Homo sapiens MCF7 GI 8.1 % 10.1016/j.ejmech.2018.10.062
Homo sapiens MCF7 GI50 18240.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens MCF7 IC50 6330.0 nM 10.1016/j.ejmech.2019.02.033
Homo sapiens MCF7 IC50 7120.0 nM 10.1016/j.ejmech.2018.04.029
Homo sapiens MCF7 IC50 10000.0 nM 10.1016/j.bmc.2013.01.004
Homo sapiens MCF7 IC50 10000.0 nM 10.1016/j.bmc.2015.02.026
Homo sapiens MCF7 IC50 10000.0 nM 10.1016/j.bmcl.2016.05.004
Homo sapiens MCF7 IC50 10000.0 nM 10.1016/j.ejmech.2013.08.009
Homo sapiens MCF7 IC50 10000.0 nM 10.1016/j.ejmech.2015.12.023
Homo sapiens MCF7 IC50 11300.0 nM 10.1016/j.bmc.2018.04.050
Homo sapiens MCF7 IC50 11500.0 nM 10.1021/jm900424a
Homo sapiens MCF7 IC50 25000.0 nM 10.1016/j.ejmech.2018.12.012
Homo sapiens MCF7 IC50 25550.0 nM 10.1016/j.bmcl.2023.129144
Homo sapiens MCF7 IC50 30000.0 nM 10.1021/jm800988r
Homo sapiens MCF7 IC50 31622.78 nM 10.1021/jm800988r
Homo sapiens MC-IXC Activity 1.155 None 10.1073/pnas.0707498104
Homo sapiens MDA-MB-134-VI IC50 82599.61 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-157 Activity 1.231 None 10.1073/pnas.0707498104
Homo sapiens MDA-MB-231 Activity 1.495 None 10.1073/pnas.0707498104
Homo sapiens MDA-MB-231 EC50 nan None 10.1021/acs.jmedchem.6b00087
Homo sapiens MDA-MB-231 GI50 18660.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens MDA-MB-231 IC50 37000.0 nM 10.1021/jm800988r
Homo sapiens MDA-MB-231 IC50 39810.72 nM 10.1021/jm800988r
Homo sapiens MDA-MB-361 Activity 1.318 None 10.1073/pnas.0707498104
Homo sapiens MDA-MB-415 Activity 1.332 None 10.1073/pnas.0707498104
Homo sapiens MDA-MB-435 GI 7.4 % 10.1016/j.ejmech.2018.10.062
Homo sapiens MDA-MB-435 GI50 17910.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens MDA-MB-453 Activity 0.799 None 10.1073/pnas.0707498104
Homo sapiens MDA-MB-453 IC50 12840.0 nM 10.1016/j.ejmech.2019.02.033
Homo sapiens MDA-MB-468 Activity 0.981 None 10.1073/pnas.0707498104
Homo sapiens MDA-MB-468 GI 29.1 % 10.1016/j.ejmech.2018.10.062
Homo sapiens MDA-MB-468 GI50 nan None 10.1016/j.ejmech.2020.112756
Homo sapiens MDA-MB-468 IC50 15848.93 nM 10.1021/jm800988r
Homo sapiens MDA-MB-468 IC50 17000.0 nM 10.1021/jm800988r
Homo sapiens ME-180 Activity 0.828 None 10.1073/pnas.0707498104
Homo sapiens MEC1 GI50 10000.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens MEG-01 Activity nan None 10.1021/acs.jmedchem.6b01290
Homo sapiens MEG-01 GI50 45.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens MEG-01 GI50 280.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens MEG-01 IC50 89.21 nM 10.6019/CHEMBL1201861
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens MEL-HO Activity 1.02 None 10.1073/pnas.0707498104
Homo sapiens MEL-JUSO Activity 0.743 None 10.1073/pnas.0707498104
Homo sapiens Membrane-associated phosphatidylinositol transfer protein 1 Activity 93.0 % 10.1021/jm101396q
Homo sapiens Membrane-associated progesterone receptor component 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MeWo Activity 0.936 None 10.1073/pnas.0707498104
Homo sapiens MFE-280 Activity 1.003 None 10.1073/pnas.0707498104
Homo sapiens MFE-296 Activity 1.033 None 10.1073/pnas.0707498104
Homo sapiens MFH-ino IC50 210999.55 nM 10.6019/CHEMBL1201861
Homo sapiens MFM-223 IC50 225361.78 nM 10.6019/CHEMBL1201861
Homo sapiens MG-63 Activity nan None 10.1021/acs.jmedchem.1c01732
Homo sapiens MG-63 IC50 31690.0 nM 10.1021/acs.jmedchem.1c01732
Homo sapiens MHH-CALL-2 IC50 321214.46 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-NB-11 IC50 198071.09 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-PREB-1 IC50 184940.29 nM 10.6019/CHEMBL1201861
Homo sapiens MIA PaCa-2 Activity 1.083 None 10.1073/pnas.0707498104
Homo sapiens Microtubule-associated serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Midasin Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Misshapen-like kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Misshapen-like kinase 1 Ki 7943.28 nM None
Homo sapiens Mitogen-activated protein kinase 15 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 15 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase 15 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 10 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 10 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 10 Ki 3162.28 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 12 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 13 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 15 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd nan None 10.1038/nbt1068
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Activity 5.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Inhibition 5.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Mitogen-activated protein kinase kinase kinase 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Ki 3981.07 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Ki 5011.87 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Ki 7943.28 nM None
Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mixed lineage kinase 7 Kd 2600.0 nM 10.1038/nbt1358
Homo sapiens Mixed lineage kinase 7 Kd 2600.0 nM 10.1038/nbt.1990
Homo sapiens Mixed lineage kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mixed lineage kinase 7 Ki 7943.28 nM None
Homo sapiens MKN-28 Activity 1.102 None 10.1073/pnas.0707498104
Homo sapiens MKN-45 Activity 0.931 None 10.1073/pnas.0707498104
Homo sapiens MKN-7 Activity 1.117 None 10.1073/pnas.0707498104
Homo sapiens MKN-74 Activity 1.024 None 10.1073/pnas.0707498104
Homo sapiens ML-2 IC50 388449.43 nM 10.6019/CHEMBL1201861
Homo sapiens MLMA IC50 179388.35 nM 10.6019/CHEMBL1201861
Homo sapiens MMAC-SF IC50 194728.25 nM 10.6019/CHEMBL1201861
Homo sapiens MN-60 IC50 225224.8 nM 10.6019/CHEMBL1201861
Homo sapiens Mo IC50 375174.03 nM 10.6019/CHEMBL1201861
Homo sapiens MOG-G-UVW Activity 0.928 None 10.1073/pnas.0707498104
Homo sapiens MOLM-13 GI50 1000.0 nM 10.1021/acs.jmedchem.9b01229
Homo sapiens MOLT-13 IC50 473554.97 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-16 IC50 45075.19 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 GI 18.0 % 10.1016/j.ejmech.2018.10.062
Homo sapiens MOLT-4 GI 18.0 % 10.1016/j.ejmech.2020.112710
Homo sapiens MOLT-4 GI50 5130.0 nM 10.1016/j.ejmech.2020.112710
Homo sapiens MOLT-4 GI50 5130.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens MOLT-4 IC50 313096.36 nM 10.6019/CHEMBL1201861
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens MONO-MAC-6 IC50 119632.08 nM 10.6019/CHEMBL1201861
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 12589.3 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 19952.6 nM None
Homo sapiens MPP-89 IC50 25687.38 nM 10.6019/CHEMBL1201861
Homo sapiens MRK-nu-1 IC50 118118.22 nM 10.6019/CHEMBL1201861
Homo sapiens MS-1 IC50 239892.28 nM 10.6019/CHEMBL1201861
Homo sapiens MSTO-211H Activity 1.186 None 10.1073/pnas.0707498104
Homo sapiens MSTO-211H IC50 461377.23 nM 10.6019/CHEMBL1201861
Homo sapiens Multidrug and toxin extrusion protein 1 IC50 40.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 1 IC50 50.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 1 IC50 350.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 2 IC50 350.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 2 IC50 2900.0 nM 10.1021/jm301302s
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Multifunctional protein ADE2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MV4-11 Activity 82.0 % 10.1016/j.ejmech.2011.07.045
Homo sapiens MV4-11 Activity 105.0 % 10.1016/j.ejmech.2011.07.045
Homo sapiens MV4-11 GI50 10000.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens MV4-11 GI50 10000.0 nM 10.1021/acs.jmedchem.6b00200
Homo sapiens MV4-11 IC50 214355.32 nM 10.6019/CHEMBL1201861
Homo sapiens Myelin transcription factor 1 Activity 5.0 % 10.1016/j.ejmech.2012.06.007
Homo sapiens Myelin transcription factor 1 IC50 nan None 10.1016/j.ejmech.2012.06.007
Homo sapiens Myosin-10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin-14 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin IIIA Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin IIIA Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin-IIIB Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin-IIIB Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin light chain kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin light chain kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens myosin light chain kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens myosin light chain kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens myosin light chain kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Myosin light chain kinase family member 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin light chain kinase family member 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin light chain kinase, smooth muscle Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myotonin-protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myotonin-protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MZ1-PC IC50 223961.02 nM 10.6019/CHEMBL1201861
Homo sapiens MZ2-MEL IC50 115687.2 nM 10.6019/CHEMBL1201861
Homo sapiens MZ7-mel IC50 95904.03 nM 10.6019/CHEMBL1201861
Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens NALM-6 IC50 498955.54 nM 10.6019/CHEMBL1201861
Homo sapiens NB1 IC50 424478.35 nM 10.6019/CHEMBL1201861
Homo sapiens NB10 IC50 26469.95 nM 10.6019/CHEMBL1201861
Homo sapiens NB13 IC50 286470.05 nM 10.6019/CHEMBL1201861
Homo sapiens NB14 IC50 98920.75 nM 10.6019/CHEMBL1201861
Homo sapiens NB17 IC50 304279.9 nM 10.6019/CHEMBL1201861
Homo sapiens NB5 IC50 319709.25 nM 10.6019/CHEMBL1201861
Homo sapiens NB6 IC50 134419.43 nM 10.6019/CHEMBL1201861
Homo sapiens NB69 Activity 0.923 None 10.1073/pnas.0707498104
Homo sapiens NB69 IC50 429542.2 nM 10.6019/CHEMBL1201861
Homo sapiens NB7 IC50 231669.09 nM 10.6019/CHEMBL1201861
Homo sapiens NCCIT IC50 95329.18 nM 10.6019/CHEMBL1201861
Homo sapiens NCI/ADR-RES GI -0.5 % 10.1016/j.ejmech.2018.10.062
Homo sapiens NCI/ADR-RES GI50 22960.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens NCI-H1048 Activity 0.987 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1092 IC50 84019.68 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1155 IC50 273565.48 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H128 IC50 145178.93 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1299 Activity 0.989 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1299 IC50 422057.26 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1304 IC50 530570.58 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1355 IC50 118078.07 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1395 IC50 51783.47 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1417 IC50 340188.2 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1436 IC50 978.01 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1437 Activity 1.043 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1522 IC50 401404.64 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1563 Activity 0.988 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1573 Activity 1.257 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1581 Activity 0.853 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1581 IC50 142608.77 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1623 Activity 1.171 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1648 IC50 154650.08 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1650 Activity 1.092 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1651 Activity 0.976 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1666 Activity 1.009 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1693 Activity 1.11 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1694 IC50 108148.69 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1703 Activity 0.725 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1703 GI50 230.0 nM 10.1016/j.ejmech.2018.03.003
Homo sapiens NCI-H1703 GI50 2100.0 nM 10.1016/j.ejmech.2018.03.003
Homo sapiens NCI-H1734 Activity 0.964 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1755 Activity 0.95 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1770 IC50 5572.62 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1792 Activity 0.983 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1793 Activity 1.082 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1838 IC50 195884.66 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H187 IC50 160844.97 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1882 IC50 140340.55 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1963 IC50 193801.61 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1975 Activity 1.11 None 10.1073/pnas.0707498104
Homo sapiens NCI-H1975 EC50 nan None 10.1021/acs.jmedchem.6b00087
Homo sapiens NCI-H2009 Activity 1.075 None 10.1073/pnas.0707498104
Homo sapiens NCI-H2029 Activity 1.144 None 10.1073/pnas.0707498104
Homo sapiens NCI-H2030 Activity 0.941 None 10.1073/pnas.0707498104
Homo sapiens NCI-H2081 IC50 138987.5 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2087 Activity 1.059 None 10.1073/pnas.0707498104
Homo sapiens NCI-H209 IC50 154819.05 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2107 IC50 375856.72 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2122 Activity 1.14 None 10.1073/pnas.0707498104
Homo sapiens NCI-H2126 IC50 124487.59 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2141 IC50 198022.77 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2170 Activity 1.227 None 10.1073/pnas.0707498104
Homo sapiens NCI-H2171 IC50 107351.45 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2196 Activity 1.125 None 10.1073/pnas.0707498104
Homo sapiens NCI-H2196 IC50 75637.86 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2228 Activity 1.038 None 10.1073/pnas.0707498104
Homo sapiens NCI-H226 GI 10.6 % 10.1016/j.ejmech.2018.10.062
Homo sapiens NCI-H226 GI50 18110.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens NCI-H226 IC50 287129.12 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H23 Activity 1.147 None 10.1073/pnas.0707498104
Homo sapiens NCI-H23 GI 17.1 % 10.1016/j.ejmech.2018.10.062
Homo sapiens NCI-H23 GI50 14960.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens NCI-H23 IC50 549401.22 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2342 Activity 1.122 None 10.1073/pnas.0707498104
Homo sapiens NCI-H2347 Activity 1.19 None 10.1073/pnas.0707498104
Homo sapiens NCI-H2405 Activity 1.058 None 10.1073/pnas.0707498104
Homo sapiens NCI-H2452 Activity 1.001 None 10.1073/pnas.0707498104
Homo sapiens NCI-H322M GI nan None 10.1016/j.ejmech.2018.10.062
Homo sapiens NCI-H322M GI50 22800.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens NCI-H322M IC50 143008.78 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H345 IC50 410997.86 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H358 Activity 1.177 None 10.1073/pnas.0707498104
Homo sapiens NCI-H441 Activity 1.117 None 10.1073/pnas.0707498104
Homo sapiens NCI-H446 IC50 362014.04 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H460 Activity 1.024 None 10.1073/pnas.0707498104
Homo sapiens NCI-H460 GI 3.2 % 10.1016/j.ejmech.2018.10.062
Homo sapiens NCI-H460 GI50 16180.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens NCI-H460 IC50 24000.0 nM 10.1021/jm800988r
Homo sapiens NCI-H460 IC50 25118.86 nM 10.1021/jm800988r
Homo sapiens NCI-H510A IC50 17244.17 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H520 Activity 1.2 None 10.1073/pnas.0707498104
Homo sapiens NCI-H522 Activity 0.916 None 10.1073/pnas.0707498104
Homo sapiens NCI-H522 GI nan None 10.1016/j.ejmech.2018.10.062
Homo sapiens NCI-H522 GI50 16410.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens NCI-H524 IC50 132854.69 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H526 IC50 92410.35 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H596 Activity 0.985 None 10.1073/pnas.0707498104
Homo sapiens NCI-H630 Activity 0.935 None 10.1073/pnas.0707498104
Homo sapiens NCI-H64 IC50 351372.88 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H647 Activity 0.979 None 10.1073/pnas.0707498104
Homo sapiens NCI-H661 Activity 1.162 None 10.1073/pnas.0707498104
Homo sapiens NCI-H69 IC50 31622.78 nM 10.1021/jm800988r
Homo sapiens NCI-H69 IC50 32000.0 nM 10.1021/jm800988r
Homo sapiens NCI-H69 IC50 109574.64 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H716 IC50 126345.09 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H719 IC50 267431.64 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H720 IC50 117067.65 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H727 Activity 0.965 None 10.1073/pnas.0707498104
Homo sapiens NCI-H747 IC50 205545.21 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H748 IC50 251812.06 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H810 Activity 1.103 None 10.1073/pnas.0707498104
Homo sapiens NCI-H82 IC50 193557.38 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H838 Activity 1.124 None 10.1073/pnas.0707498104
Homo sapiens NCI-H889 IC50 360900.39 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-N87 Activity 1.004 None 10.1073/pnas.0707498104
Homo sapiens NEC8 IC50 195520.65 nM 10.6019/CHEMBL1201861
Homo sapiens Nerve growth factor receptor Trk-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Nerve growth factor receptor Trk-A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Nerve growth factor receptor Trk-A Kd nan None 10.1038/nbt1068
Homo sapiens Nerve growth factor receptor Trk-A Ki 2511.89 nM None
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Inhibition 34.0 % 10.1038/nchembio760
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Ki 3981.07 nM None
Homo sapiens NH-12 IC50 589293.88 nM 10.6019/CHEMBL1201861
Homo sapiens NH-6 Activity 0.965 None 10.1073/pnas.0707498104
Homo sapiens NHDF IC50 25000.0 nM 10.1016/j.ejmech.2018.12.012
Homo sapiens NKM-1 IC50 19355.24 nM 10.6019/CHEMBL1201861
Homo sapiens NMC-G1 IC50 98455.43 nM 10.6019/CHEMBL1201861
Homo sapiens no-10 IC50 108599.41 nM 10.6019/CHEMBL1201861
Homo sapiens no-11 IC50 108068.47 nM 10.6019/CHEMBL1201861
Homo sapiens NOMO-1 IC50 104287.03 nM 10.6019/CHEMBL1201861
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens NOS-1 IC50 1653.83 nM 10.6019/CHEMBL1201861
Homo sapiens NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) IC50 30000.0 nM 10.1021/jm060380k
Homo sapiens NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) IC50 100000.0 nM 10.1021/jm060380k
Homo sapiens NT-3 growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NT-3 growth factor receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens NT-3 growth factor receptor Ki 3162.28 nM None
Homo sapiens NTERA-2-cl-D1 IC50 30509.25 nM 10.6019/CHEMBL1201861
Homo sapiens NUAK family SNF1-like kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NUAK family SNF1-like kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens NUAK family SNF1-like kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NUAK family SNF1-like kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens NUAK family SNF1-like kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Nucleolar GTP-binding protein 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens NUGC-3 Activity 0.96 None 10.1073/pnas.0707498104
Homo sapiens NUGC-4 Activity 1.02 None 10.1073/pnas.0707498104
Homo sapiens OAW-28 Activity 0.917 None 10.1073/pnas.0707498104
Homo sapiens OAW-42 Activity 0.981 None 10.1073/pnas.0707498104
Homo sapiens Obg-like ATPase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens OCI-AML2 GI50 10000.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens OCI-AML2 IC50 490734.38 nM 10.6019/CHEMBL1201861
Homo sapiens OCUB-M IC50 176185.78 nM 10.6019/CHEMBL1201861
Homo sapiens OE19 Activity 1.302 None 10.1073/pnas.0707498104
Homo sapiens OE33 Activity 1.091 None 10.1073/pnas.0707498104
Homo sapiens OMC-1 IC50 224595.5 nM 10.6019/CHEMBL1201861
Homo sapiens ONS-76 IC50 187017.28 nM 10.6019/CHEMBL1201861
Homo sapiens OPM-2 IC50 447511.84 nM 10.6019/CHEMBL1201861
Homo sapiens OS-RC-2 IC50 162885.58 nM 10.6019/CHEMBL1201861
Homo sapiens OV-1063 Activity 1.035 None 10.1073/pnas.0707498104
Homo sapiens OVCAR-3 GI -10.3 % 10.1016/j.ejmech.2018.10.062
Homo sapiens OVCAR-3 GI50 34200.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens OVCAR-4 GI -0.1 % 10.1016/j.ejmech.2018.10.062
Homo sapiens OVCAR-4 GI50 20040.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens OVCAR-4 IC50 132324.47 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-5 Activity 1.092 None 10.1073/pnas.0707498104
Homo sapiens OVCAR-5 GI -22.8 % 10.1016/j.ejmech.2018.10.062
Homo sapiens OVCAR-5 GI50 580.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens OVCAR-8 Activity 0.776 None 10.1073/pnas.0707498104
Homo sapiens OVCAR-8 GI 8.4 % 10.1016/j.ejmech.2018.10.062
Homo sapiens OVCAR-8 GI50 27670.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens P30-OHK IC50 412229.82 nM 10.6019/CHEMBL1201861
Homo sapiens P31-FUJ IC50 545652.32 nM 10.6019/CHEMBL1201861
Homo sapiens PA-1 Activity 0.978 None 10.1073/pnas.0707498104
Homo sapiens PANC-1 Activity 1.124 None 10.1073/pnas.0707498104
Homo sapiens PANC-1 FC 2.0 None 10.1016/j.ejmech.2020.113032
Homo sapiens PAS domain-containing serine/threonine-protein kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens PC-14 Activity 1.019 None 10.1073/pnas.0707498104
Homo sapiens PC-3 Activity 1.038 None 10.1073/pnas.0707498104
Homo sapiens PC-3 FC 0.5 None 10.1038/nchembio790
Homo sapiens PC-3 GI 10.6 % 10.1016/j.ejmech.2018.10.062
Homo sapiens PC-3 GI50 21380.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens PC-3 IC50 24000.0 nM 10.1021/jm800988r
Homo sapiens PC-3 IC50 25118.86 nM 10.1021/jm800988r
Homo sapiens PC-9 Activity 1.009 None 10.1073/pnas.0707498104
Homo sapiens PDZ-binding kinase Ki 10000.0 nM None
Homo sapiens Peripheral plasma membrane protein CASK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Peroxisomal acyl-coenzyme A oxidase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Peroxisomal acyl-coenzyme A oxidase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens PF-382 IC50 210553.55 nM 10.6019/CHEMBL1201861
Homo sapiens P-glycoprotein 1 Activity nan None 10.1182/blood-2003-12-4276
Homo sapiens P-glycoprotein 1 Hill coefficient 1.18 None 10.1016/j.bmc.2007.07.024
Homo sapiens P-glycoprotein 1 IC50 580.0 nM 10.1021/acs.jmedchem.1c00246
Homo sapiens P-glycoprotein 1 IC50 7244.36 nM 10.1016/j.bmc.2007.07.024
Homo sapiens P-glycoprotein 1 IC50 7244.36 nM 10.1016/j.bmc.2008.07.034
Homo sapiens P-glycoprotein 1 IC50 12589.25 nM 10.1016/j.bmc.2007.07.024
Homo sapiens P-glycoprotein 1 Ratio 8.543 None 10.1021/acs.jmedchem.0c02011
Homo sapiens P-glycoprotein 1 Ratio 152.14 None 10.1021/acs.jmedchem.1c00246
Homo sapiens Phenylalanine--tRNA ligase beta subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylethanolamine-binding protein 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma Kd 380.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma Kd 4342.0 nM 10.1126/science.aan4368
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Phosphofructokinase platelet type Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd nan None 10.1038/nbt1068
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd nan None 10.1038/nbt1068
Homo sapiens Phosphorylase kinase gamma subunit 2 Ki 5011.87 nM None
Homo sapiens PI3-kinase p110-alpha subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PI3-kinase p110-alpha subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PI3-kinase p110-beta subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PI3-kinase p110-delta subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PI3-kinase p110-gamma subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PI4-kinase beta subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Plasma fCmax 250.0 nM 10.1021/ml300378n
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Platelet-derived growth factor receptor IC50 50.0 nM 10.1016/S0960-894X(96)00601-4
Homo sapiens Platelet-derived growth factor receptor IC50 50.0 nM 10.1021/jm058225d
Homo sapiens Platelet-derived growth factor receptor IC50 400.0 nM 10.1016/j.bmc.2015.10.035
Homo sapiens Platelet-derived growth factor receptor alpha Activity 0.0 % 10.1021/jm101396q
Homo sapiens Platelet-derived growth factor receptor alpha Activity 0.15 % 10.1021/jm101396q
Homo sapiens Platelet-derived growth factor receptor alpha EC50 90.0 nM 10.1073/pnas.0707498104
Homo sapiens Platelet-derived growth factor receptor alpha GI50 10.7 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Platelet-derived growth factor receptor alpha GI50 34.0 nM 10.1016/j.ejmech.2018.03.003
Homo sapiens Platelet-derived growth factor receptor alpha GI50 34.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Platelet-derived growth factor receptor alpha GI50 46.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Platelet-derived growth factor receptor alpha GI50 567.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Platelet-derived growth factor receptor alpha GI50 10000.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Platelet-derived growth factor receptor alpha IC50 1.995 nM 10.1021/jm400798j
Homo sapiens Platelet-derived growth factor receptor alpha IC50 4.6 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Platelet-derived growth factor receptor alpha IC50 18.0 nM 10.1021/jm800188g
Homo sapiens Platelet-derived growth factor receptor alpha IC50 71.0 nM 10.1021/acs.jmedchem.1c01732
Homo sapiens Platelet-derived growth factor receptor alpha IC50 72.0 nM 10.1016/j.bmc.2010.08.026
Homo sapiens Platelet-derived growth factor receptor alpha IC50 96.0 nM 10.1021/jm0506423
Homo sapiens Platelet-derived growth factor receptor alpha IC50 160.0 nM 10.1021/jm101396q
Homo sapiens Platelet-derived growth factor receptor alpha IC50 642.0 nM 10.1021/acs.jmedchem.5b01106
Homo sapiens Platelet-derived growth factor receptor alpha Inhibition 89.0 % 10.1038/nchembio760
Homo sapiens Platelet-derived growth factor receptor alpha Inhibition nan % 10.1016/j.ejmech.2018.03.003
Homo sapiens Platelet-derived growth factor receptor alpha Kd 31.0 nM 10.1038/nbt1358
Homo sapiens Platelet-derived growth factor receptor alpha Kd 31.0 nM 10.1038/nbt.1990
Homo sapiens Platelet-derived growth factor receptor alpha Ki 158.49 nM None
Homo sapiens Platelet-derived growth factor receptor beta Activity 0.0 % 10.1021/jm101396q
Homo sapiens Platelet-derived growth factor receptor beta Activity 0.15 % 10.1021/jm101396q
Homo sapiens Platelet-derived growth factor receptor beta GI50 19.0 nM 10.1016/j.ejmech.2018.03.003
Homo sapiens Platelet-derived growth factor receptor beta GI50 19.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Platelet-derived growth factor receptor beta GI50 102.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Platelet-derived growth factor receptor beta IC50 72.0 nM 10.1016/j.bmc.2010.08.026
Homo sapiens Platelet-derived growth factor receptor beta IC50 240.0 nM 10.1021/jm020143r
Homo sapiens Platelet-derived growth factor receptor beta IC50 240.0 nM 10.1021/jm800988r
Homo sapiens Platelet-derived growth factor receptor beta IC50 386.0 nM 10.1038/nchembio799
Homo sapiens Platelet-derived growth factor receptor beta IC50 607.0 nM 10.1021/acs.jmedchem.1c01732
Homo sapiens Platelet-derived growth factor receptor beta Inhibition 43.0 % 10.1038/nchembio760
Homo sapiens Platelet-derived growth factor receptor beta Kd 14.0 nM 10.1038/nbt1358
Homo sapiens Platelet-derived growth factor receptor beta Kd 14.0 nM 10.1038/nbt.1990
Homo sapiens Platelet-derived growth factor receptor beta Kd 28.0 nM 10.1038/nbt1068
Homo sapiens Platelet-derived growth factor receptor beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Platelet-derived growth factor receptor beta Ki 50.12 nM None
Homo sapiens Prelamin-A/C Potency 11220.2 nM None
Homo sapiens Probable ATP-dependent RNA helicase DDX6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C alpha IC50 100000.0 nM 10.1016/S0960-894X(96)00601-4
Homo sapiens Protein kinase C alpha IC50 100000.0 nM 10.1021/jm058225d
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Inhibition 17.0 % 10.1038/nchembio760
Homo sapiens Protein kinase C alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C alpha Kd nan None 10.1038/nbt1068
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Protein kinase C beta Inhibition 10.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Protein kinase C beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C delta IC50 100000.0 nM 10.1016/S0960-894X(96)00601-4
Homo sapiens Protein kinase C delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C delta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C delta Ki 7943.28 nM None
Homo sapiens Protein kinase C epsilon Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C epsilon Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C eta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C eta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C gamma Ki 7943.28 nM None
Homo sapiens Protein kinase C iota Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C iota Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C iota Ki 5011.87 nM None
Homo sapiens Protein kinase C mu Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C mu Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C nu Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C nu Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C nu Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C nu Ki 5011.87 nM None
Homo sapiens Protein kinase C theta Inhibition 14.0 % 10.1038/nchembio760
Homo sapiens Protein kinase C theta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C theta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C theta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C theta Ki 2511.89 nM None
Homo sapiens Protein kinase C zeta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C zeta Ki 7943.28 nM None
Homo sapiens Protein kinase N1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase N1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase N1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase N2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase N2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase N2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase N2 Ki 7943.28 nM None
Homo sapiens Protein tyrosine kinase 2 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein tyrosine kinase 2 beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein tyrosine kinase 2 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein tyrosine kinase 2 beta Ki 1584.89 nM None
Homo sapiens Proto-oncogene C-crk Activity 33.0 % 10.1039/C7MD00619E
Homo sapiens Proto-oncogene C-crk Inhibition nan % 10.1039/C7MD00619E
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Ki 2511.89 nM None
Homo sapiens PSN1 IC50 146962.29 nM 10.6019/CHEMBL1201861
Homo sapiens Putative uncharacterized serine/threonine-protein kinase SgK110 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Pyridoxal kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens QIMR-WIL IC50 210108.07 nM 10.6019/CHEMBL1201861
Homo sapiens quadruplex DNA Delta Tm 0.1 degrees C 10.1016/j.bmc.2018.04.050
Homo sapiens quadruplex DNA Delta Tm 0.2 degrees C 10.1016/j.bmc.2018.04.050
Homo sapiens Quinone reductase 2 Activity nan None 10.1021/jm3001339
Homo sapiens Quinone reductase 2 IC50 43.0 nM 10.1038/nrd.2016.266
Homo sapiens Quinone reductase 2 IC50 82.0 nM 10.1021/acsmedchemlett.6b00441
Homo sapiens Quinone reductase 2 IC50 400.0 nM 10.1021/jm3001339
Homo sapiens Quinone reductase 2 IC50 nan None 10.1021/jm3001339
Homo sapiens Quinone reductase 2 Kd 41.0 nM 10.1126/science.aan4368
Homo sapiens Quinone reductase 2 Ki 39.0 nM 10.1038/nrd.2016.266
Homo sapiens Quinone reductase 2 Ki nan None 10.1021/jm3001339
Homo sapiens Raji IC50 504830.13 nM 10.6019/CHEMBL1201861
Homo sapiens Ramos-2G6-4C10 IC50 89871.87 nM 10.6019/CHEMBL1201861
Homo sapiens Ras-related protein Rab-10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-27A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-6A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens RCC10RGB IC50 170559.81 nM 10.6019/CHEMBL1201861
Homo sapiens RCM-1 Activity 1.004 None 10.1073/pnas.0707498104
Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Receptor-interacting serine/threonine-protein kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Receptor-interacting serine/threonine-protein kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 0.06 nM 10.1016/j.ejmech.2022.114502
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Inhibition -21.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Inhibition nan % 10.1038/nchembio760
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd nan None 10.1038/nbt1068
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki 1584.89 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Ki 3981.07 nM None
Homo sapiens Receptor tyrosine-protein kinase erbB-3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens REH IC50 335735.28 nM 10.6019/CHEMBL1201861
Homo sapiens RERF-LC-MS Activity 0.969 None 10.1073/pnas.0707498104
Homo sapiens RH-1 IC50 537128.84 nM 10.6019/CHEMBL1201861
Homo sapiens Rho-associated protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Rho-associated protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rho-associated protein kinase 1 Ki 5011.87 nM None
Homo sapiens Rho-associated protein kinase 2 Inhibition 8.0 % 10.1038/nchembio760
Homo sapiens Rho-associated protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Rho-associated protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rho-associated protein kinase 2 Ki 6309.57 nM None
Homo sapiens Rhodopsin kinase Activity 2.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Rhodopsin kinase Inhibition 2.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Rhodopsin kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase 1 Inhibition 8.0 % 10.1038/nchembio760
Homo sapiens Ribosomal protein S6 kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase 1 Ki 6309.57 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 1 Inhibition 58.0 % 10.1038/nchembio760
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd nan None 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd nan None 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 3 Ki 5011.87 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 4 Ki 1584.89 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 5 Activity 49.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Ribosomal protein S6 kinase alpha 5 Inhibition 49.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd nan None 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 5 Ki 1995.26 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens RKO IC50 188081.62 nM 10.6019/CHEMBL1201861
Homo sapiens RL IC50 236613.97 nM 10.6019/CHEMBL1201861
Homo sapiens RL95-2 IC50 50071.05 nM 10.6019/CHEMBL1201861
Homo sapiens RNA cytidine acetyltransferase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens RO82-W-1 Activity 1.213 None 10.1073/pnas.0707498104
Homo sapiens RPMI-6666 IC50 71031.97 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-7951 Activity 0.783 None 10.1073/pnas.0707498104
Homo sapiens RPMI-8226 GI 12.6 % 10.1016/j.ejmech.2018.10.062
Homo sapiens RPMI-8226 GI 12.6 % 10.1016/j.ejmech.2020.112710
Homo sapiens RPMI-8226 GI50 6050.0 nM 10.1016/j.ejmech.2020.112710
Homo sapiens RPMI-8226 GI50 6050.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens RPMI-8226 IC50 225263.76 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI 8402 IC50 316016.36 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8866 IC50 662059.88 nM 10.6019/CHEMBL1201861
Homo sapiens RS4-11 IC50 20330.84 nM 10.6019/CHEMBL1201861
Homo sapiens RT-112 Activity 0.998 None 10.1073/pnas.0707498104
Homo sapiens RT-4 Activity 1.181 None 10.1073/pnas.0707498104
Homo sapiens RVH-421 Activity 1.228 None 10.1073/pnas.0707498104
Homo sapiens RXF 393 GI 5.7 % 10.1016/j.ejmech.2018.10.062
Homo sapiens RXF 393 GI50 15070.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens RXF 393 IC50 189234.12 nM 10.6019/CHEMBL1201861
Homo sapiens S-117 Activity 0.964 None 10.1073/pnas.0707498104
Homo sapiens S-adenosylmethionine synthase isoform type-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens SAOS-2 Activity 1.02 None 10.1073/pnas.0707498104
Homo sapiens SAOS-2 IC50 15010.0 nM 10.1021/acs.jmedchem.1c01732
Homo sapiens SAOS-2 IC50 25118.86 nM 10.1021/jm800988r
Homo sapiens SAOS-2 IC50 26000.0 nM 10.1021/jm800988r
Homo sapiens SBC-1 IC50 178639.71 nM 10.6019/CHEMBL1201861
Homo sapiens SBC-3 Activity 0.905 None 10.1073/pnas.0707498104
Homo sapiens SBC-5 Activity 0.912 None 10.1073/pnas.0707498104
Homo sapiens SCaBER Activity 1.055 None 10.1073/pnas.0707498104
Homo sapiens SCC-15 IC50 10778.8 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-3 IC50 364969.58 nM 10.6019/CHEMBL1201861
Homo sapiens SCCH-26 Activity 1.104 None 10.1073/pnas.0707498104
Homo sapiens SCH Activity 1.208 None 10.1073/pnas.0707498104
Homo sapiens SCH IC50 4700.0 nM 10.1016/j.ejmech.2019.112029
Homo sapiens SCLC-21H Activity 0.841 None 10.1073/pnas.0707498104
Homo sapiens SCLC-21H IC50 20124.58 nM 10.6019/CHEMBL1201861
Homo sapiens Septin-9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 10 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 10 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 10 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 11 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 11 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 16 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 16 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 16 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 16 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 17A Activity 5.2 % 10.1021/jm101396q
Homo sapiens Serine/threonine-protein kinase 17A Kd 2800.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 17A Kd 5300.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 17A Kd 5300.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 17A Ki 3981.07 nM None
Homo sapiens Serine/threonine-protein kinase 17B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 17B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 17B Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 2 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase 24 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 24 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 24 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 25 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 25 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 32A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 32B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 32B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 32C Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 32C Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 33 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 33 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 35 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 36 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 36 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 36 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 38 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 38-like Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 38-like Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 38-like Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase AKT Inhibition 46.0 % 10.1038/nchembio760
Homo sapiens Serine/threonine-protein kinase AKT Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase AKT Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT2 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT3 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase A-Raf Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-A Activity -38.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Serine/threonine-protein kinase Aurora-A Inhibition -38.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Serine/threonine-protein kinase Aurora-A Inhibition 16.0 % 10.1038/nchembio760
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase Aurora-A Ki 2511.89 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-B Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase B-raf Activity 20.0 % 10.1021/jm101396q
Homo sapiens Serine/threonine-protein kinase B-raf IC50 100000.0 nM 10.1016/j.bmc.2010.05.063
Homo sapiens Serine/threonine-protein kinase B-raf Inhibition -44.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Serine/threonine-protein kinase B-raf Inhibition 13.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Serine/threonine-protein kinase B-raf Inhibition 13.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Serine/threonine-protein kinase B-raf Kd 3300.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase B-raf Kd 3300.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase B-raf Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase B-raf Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase B-raf Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Chk1 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase Chk2 Inhibition 17.0 % 10.1038/nchembio760
Homo sapiens Serine/threonine-protein kinase Chk2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Chk2 Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase c-TAK1 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase D2 Inhibition 11.0 % 10.1038/nchembio760
Homo sapiens Serine/threonine-protein kinase D2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase D2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase D2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase D2 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase DCLK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase DCLK1 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase DCLK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase DCLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase EEF2K Ki 3981.07 nM None
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase GAK Activity 5.1 % 10.1021/jm101396q
Homo sapiens Serine/threonine-protein kinase GAK Kd 1000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase GAK Kd 1000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase GAK Kd 3600.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase GAK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ICK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ICK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ILK-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase LATS2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase LATS2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MAK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MARK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MARK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK-A Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MST1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase MST2 Activity 4.8 % 10.1021/jm101396q
Homo sapiens Serine/threonine-protein kinase MST2 Inhibition 15.0 % 10.1038/nchembio760
Homo sapiens Serine/threonine-protein kinase MST2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MST2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST2 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase MST4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MST4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase mTOR Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase N3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek1 Activity -2.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Serine/threonine-protein kinase Nek1 Inhibition -2.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek11 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK2 Inhibition 7.0 % 10.1038/nchembio760
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase NEK2 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase Nek3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Nek3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Nek4 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase Nek5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Nek5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK6 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase NEK7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK9 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase NIM1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine protein kinase NLK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine protein kinase NLK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine protein kinase NLK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase OSR1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 1 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase PAK 2 Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 4 Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase PAK6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK6 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK7 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Inhibition 10.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PCTAIRE-3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PFTAIRE-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PFTAIRE-1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PFTAIRE-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PIM1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PIM1 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PIM2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PIM2 Ki 1584.89 nM None
Homo sapiens Serine/threonine-protein kinase PIM3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PIM3 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase PLK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PLK1 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase PLK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK3 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 7800.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 7800.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 9000.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PLK4 Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase PRKX Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PRKX Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PRKX Ki 2511.89 nM None
Homo sapiens Serine/threonine-protein kinase PRP4 homolog Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RAF Inhibition 89.0 % 10.1038/nchembio760
Homo sapiens Serine/threonine-protein kinase RAF Kd 1700.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RAF Kd 1700.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase receptor R3 Activity 14.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Serine/threonine-protein kinase receptor R3 Inhibition 14.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Serine/threonine-protein kinase receptor R3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase receptor R3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIO1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIO1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIO2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIO3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIO3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase SBK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Sgk1 Activity 3.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Serine/threonine-protein kinase Sgk1 Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Serine/threonine-protein kinase Sgk1 Inhibition 3.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Serine/threonine-protein kinase Sgk2 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase Sgk3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SIK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SIK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase SIK2 Ki 3981.07 nM None
Homo sapiens Serine/threonine-protein kinase SIK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SIK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase SRPK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SRPK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SRPK1 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase SRPK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SRPK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SRPK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TAO1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TAO1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO1 Ki 3981.07 nM None
Homo sapiens Serine/threonine-protein kinase TAO2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TAO2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TAO3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TBK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TBK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TBK1 Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase TNNI3K Kd 4300.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase TNNI3K Kd 4300.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase tousled-like 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase tousled-like 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ULK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ULK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ULK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ULK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ULK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase VRK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 1891.0 nM None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki 540.0 nM None
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter IC50 1402.0 nM None
Homo sapiens Serotonin transporter Ki 745.0 nM None
Homo sapiens Serum albumin Kd 78640.0 nM 10.1016/j.bmc.2010.01.053
Homo sapiens SF-126 IC50 97521.71 nM 10.6019/CHEMBL1201861
Homo sapiens SF-268 GI -3.8 % 10.1016/j.ejmech.2018.10.062
Homo sapiens SF-268 GI50 26300.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens SF-268 IC50 226555.29 nM 10.6019/CHEMBL1201861
Homo sapiens SF-295 Activity 0.965 None 10.1073/pnas.0707498104
Homo sapiens SF-295 GI 15.1 % 10.1016/j.ejmech.2018.10.062
Homo sapiens SF-295 GI50 19770.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens SF-539 GI 24.5 % 10.1016/j.ejmech.2018.10.062
Homo sapiens SF-539 GI50 10570.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens SF-539 IC50 156928.93 nM 10.6019/CHEMBL1201861
Homo sapiens SH-4 IC50 118993.28 nM 10.6019/CHEMBL1201861
Homo sapiens SHP77 Activity 0.948 None 10.1073/pnas.0707498104
Homo sapiens SHP77 IC50 148066.57 nM 10.6019/CHEMBL1201861
Homo sapiens SIG-M5 IC50 246472.89 nM 10.6019/CHEMBL1201861
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Signal recognition particle receptor subunit alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens SiHa Activity 0.968 None 10.1073/pnas.0707498104
Homo sapiens SIMA IC50 57331.14 nM 10.6019/CHEMBL1201861
Homo sapiens SISO Activity 0.948 None 10.1073/pnas.0707498104
Homo sapiens SJSA-1 IC50 107102.57 nM 10.6019/CHEMBL1201861
Homo sapiens SK-BR-3 Activity 0.982 None 10.1073/pnas.0707498104
Homo sapiens SK-BR-3 IC50 39000.0 nM 10.1021/jm800988r
Homo sapiens SK-BR-3 IC50 39810.72 nM 10.1021/jm800988r
Homo sapiens SK-CO-1 Activity 0.91 None 10.1073/pnas.0707498104
Homo sapiens SKG-IIIa Activity 1.17 None 10.1073/pnas.0707498104
Homo sapiens SK-HEP1 Activity 1.052 None 10.1073/pnas.0707498104
Homo sapiens SK-LMS-1 IC50 208067.8 nM 10.6019/CHEMBL1201861
Homo sapiens SK-LU-1 Activity 1.1 None 10.1073/pnas.0707498104
Homo sapiens SKM-1 IC50 311774.76 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-1 IC50 177853.65 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-2 GI nan None 10.1016/j.ejmech.2018.10.062
Homo sapiens SK-MEL-2 GI50 25000.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens SK-MEL-2 IC50 303423.04 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-28 GI -9.4 % 10.1016/j.ejmech.2018.10.062
Homo sapiens SK-MEL-28 GI50 14620.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens SK-MEL3 Activity 0.958 None 10.1073/pnas.0707498104
Homo sapiens SK-MEL-30 Activity 0.858 None 10.1073/pnas.0707498104
Homo sapiens SK-MEL-5 GI 22.3 % 10.1016/j.ejmech.2018.10.062
Homo sapiens SK-MEL-5 GI50 12130.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens SK-MES-1 Activity 1.006 None 10.1073/pnas.0707498104
Homo sapiens SK-MES-1 Activity 1.11 None 10.1073/pnas.0707498104
Homo sapiens SK-MM-2 IC50 247073.29 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-AS Activity 1.157 None 10.1073/pnas.0707498104
Homo sapiens SK-N-DZ IC50 48096.14 nM 10.6019/CHEMBL1201861
Homo sapiens SK-NEP-1 Activity 0.939 None 10.1073/pnas.0707498104
Homo sapiens SK-NEP-1 IC50 68380.32 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-FI IC50 291901.96 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-SH Activity 0.972 None 10.1073/pnas.0707498104
Homo sapiens SK-OV-3 Activity 0.977 None 10.1073/pnas.0707498104
Homo sapiens SK-OV-3 GI50 28910.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens SK-OV-3 IC50 50118.72 nM 10.1021/jm800988r
Homo sapiens SK-OV-3 IC50 53000.0 nM 10.1021/jm800988r
Homo sapiens SK-PN-DW IC50 141972.02 nM 10.6019/CHEMBL1201861
Homo sapiens SK-UT-1 IC50 154634.77 nM 10.6019/CHEMBL1201861
Homo sapiens SN12C GI 6.0 % 10.1016/j.ejmech.2018.10.062
Homo sapiens SN12C GI50 33190.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens SNB-19 GI -12.2 % 10.1016/j.ejmech.2018.10.062
Homo sapiens SNB-19 GI50 38550.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens SNB-75 GI 0.6 % 10.1016/j.ejmech.2018.10.062
Homo sapiens SNB-75 GI50 20280.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens SNB-75 IC50 115764.39 nM 10.6019/CHEMBL1201861
Homo sapiens SNF-related serine/threonine-protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens SNG-M Activity 1.019 None 10.1073/pnas.0707498104
Homo sapiens SNU1 IC50 567646.01 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-16 Activity 1.351 None 10.1073/pnas.0707498104
Homo sapiens SNU-16 IC50 269345.25 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-398 Activity 0.944 None 10.1073/pnas.0707498104
Homo sapiens SNU-449 Activity 1.275 None 10.1073/pnas.0707498104
Homo sapiens SNU-5 IC50 338405.2 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C1 IC50 245428.09 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C2B IC50 169273.88 nM 10.6019/CHEMBL1201861
Homo sapiens Solute carrier family 22 member 1 IC50 107000.0 nM 10.1021/jm301302s
Homo sapiens Solute carrier family 22 member 2 IC50 4200.0 nM 10.1021/jm301302s
Homo sapiens Solute carrier family 22 member 3 IC50 25500.0 nM 10.1021/jm301302s
Homo sapiens SPS1/STE20-related protein kinase YSK4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens SR GI 14.6 % 10.1016/j.ejmech.2018.10.062
Homo sapiens SR GI 14.6 % 10.1016/j.ejmech.2020.112710
Homo sapiens SR GI50 7140.0 nM 10.1016/j.ejmech.2020.112710
Homo sapiens SR GI50 7140.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens SR IC50 165261.16 nM 10.6019/CHEMBL1201861
Homo sapiens ST486 IC50 685.4 nM 10.6019/CHEMBL1201861
Homo sapiens STE20-related kinase adapter protein alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens STE20/SPS1-related proline-alanine-rich protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Activity 0.0 % 10.1021/jm101396q
Homo sapiens Stem cell growth factor receptor Activity 0.3 % 10.1021/jm101396q
Homo sapiens Stem cell growth factor receptor Activity nan None 10.1021/jm900424a
Homo sapiens Stem cell growth factor receptor EC50 100.0 nM 10.1073/pnas.0707498104
Homo sapiens Stem cell growth factor receptor GI nan None 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 1.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor GI50 3.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 5.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor GI50 8.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 10.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 10.0 nM 10.1021/jm4004076
Homo sapiens Stem cell growth factor receptor GI50 15.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 17.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 24.9 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Stem cell growth factor receptor GI50 27.0 nM 10.1021/acs.jmedchem.6b00902
Homo sapiens Stem cell growth factor receptor GI50 35.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 36.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Stem cell growth factor receptor GI50 39.0 nM 10.1021/acs.jmedchem.6b00200
Homo sapiens Stem cell growth factor receptor GI50 39.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Stem cell growth factor receptor GI50 39.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor GI50 45.1 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Stem cell growth factor receptor GI50 48.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 70.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 85.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 100.0 nM 10.1021/acs.jmedchem.6b00200
Homo sapiens Stem cell growth factor receptor GI50 102.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Stem cell growth factor receptor GI50 115.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor GI50 148.2 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Stem cell growth factor receptor GI50 192.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 216.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 223.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 267.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor GI50 312.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 360.0 nM 10.1021/acs.jmedchem.6b00902
Homo sapiens Stem cell growth factor receptor GI50 364.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor GI50 370.0 nM 10.1016/j.ejmech.2018.03.003
Homo sapiens Stem cell growth factor receptor GI50 370.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Stem cell growth factor receptor GI50 381.9 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Stem cell growth factor receptor GI50 392.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 400.0 nM 10.1021/acs.jmedchem.6b00200
Homo sapiens Stem cell growth factor receptor GI50 406.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor GI50 435.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 535.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 580.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 590.0 nM 10.1021/acs.jmedchem.6b00902
Homo sapiens Stem cell growth factor receptor GI50 651.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 669.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 700.0 nM 10.1021/acs.jmedchem.6b00902
Homo sapiens Stem cell growth factor receptor GI50 701.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 803.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Stem cell growth factor receptor GI50 803.1 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Stem cell growth factor receptor GI50 823.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor GI50 905.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 1100.0 nM 10.1021/acs.jmedchem.7b00841
Homo sapiens Stem cell growth factor receptor GI50 1191.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 1245.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Stem cell growth factor receptor GI50 1290.0 nM 10.1021/acs.jmedchem.6b00200
Homo sapiens Stem cell growth factor receptor GI50 1290.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Stem cell growth factor receptor GI50 1290.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor GI50 1410.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 1466.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Stem cell growth factor receptor GI50 1470.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 1523.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 1570.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor GI50 2300.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor GI50 2490.0 nM 10.1021/acs.jmedchem.6b00200
Homo sapiens Stem cell growth factor receptor GI50 2490.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Stem cell growth factor receptor GI50 2749.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 3000.0 nM 10.1021/acs.jmedchem.6b00200
Homo sapiens Stem cell growth factor receptor GI50 3000.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Stem cell growth factor receptor GI50 3947.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 5200.0 nM 10.1021/acs.jmedchem.6b00902
Homo sapiens Stem cell growth factor receptor GI50 5870.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 6670.0 nM 10.1021/acs.jmedchem.6b00200
Homo sapiens Stem cell growth factor receptor GI50 6670.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Stem cell growth factor receptor GI50 8300.0 nM 10.1021/acs.jmedchem.6b00902
Homo sapiens Stem cell growth factor receptor GI50 9600.0 nM 10.1021/acs.jmedchem.6b00902
Homo sapiens Stem cell growth factor receptor GI50 9930.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 10000.0 nM 10.1021/acs.jmedchem.6b00200
Homo sapiens Stem cell growth factor receptor GI50 10000.0 nM 10.1021/acs.jmedchem.6b00902
Homo sapiens Stem cell growth factor receptor GI50 10000.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Stem cell growth factor receptor GI50 10000.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Stem cell growth factor receptor GI50 10000.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Stem cell growth factor receptor GI50 10000.0 nM 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor GI50 10000.0 nM 10.1021/acs.jmedchem.9b00280
Homo sapiens Stem cell growth factor receptor GI50 30000.0 nM 10.1021/jm4004076
Homo sapiens Stem cell growth factor receptor IC50 16.4 nM 10.1021/acs.jmedchem.7b00841
Homo sapiens Stem cell growth factor receptor IC50 21.6 nM 10.1021/jm4004076
Homo sapiens Stem cell growth factor receptor IC50 41.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Stem cell growth factor receptor IC50 46.0 nM 10.1021/jm800188g
Homo sapiens Stem cell growth factor receptor IC50 52.0 nM 10.1016/j.bmcl.2008.05.089
Homo sapiens Stem cell growth factor receptor IC50 52.0 nM 10.1021/jm800188g
Homo sapiens Stem cell growth factor receptor IC50 53.0 nM 10.1021/acs.jmedchem.9b01229
Homo sapiens Stem cell growth factor receptor IC50 58.0 nM 10.1016/j.bmcl.2008.07.111
Homo sapiens Stem cell growth factor receptor IC50 58.0 nM 10.1021/jm901132v
Homo sapiens Stem cell growth factor receptor IC50 97.0 nM 10.1016/j.bmc.2010.08.026
Homo sapiens Stem cell growth factor receptor IC50 97.0 nM 10.1016/j.bmc.2013.03.038
Homo sapiens Stem cell growth factor receptor IC50 100.0 nM 10.1021/jm050231m
Homo sapiens Stem cell growth factor receptor IC50 100.0 nM 10.1021/jm058225d
Homo sapiens Stem cell growth factor receptor IC50 108.0 nM 10.1016/j.bmc.2013.03.038
Homo sapiens Stem cell growth factor receptor IC50 164.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Stem cell growth factor receptor IC50 219.0 nM 10.1021/jm0506423
Homo sapiens Stem cell growth factor receptor IC50 260.0 nM 10.1021/jm020143r
Homo sapiens Stem cell growth factor receptor IC50 319.0 nM 10.1021/acs.jmedchem.6b00902
Homo sapiens Stem cell growth factor receptor IC50 370.0 nM 10.1021/jm101396q
Homo sapiens Stem cell growth factor receptor IC50 400.0 nM 10.1016/j.bmc.2015.10.035
Homo sapiens Stem cell growth factor receptor IC50 400.0 nM 10.1016/j.ejmech.2019.112029
Homo sapiens Stem cell growth factor receptor IC50 400.0 nM 10.1021/jm050231m
Homo sapiens Stem cell growth factor receptor IC50 413.0 nM 10.1038/nchembio799
Homo sapiens Stem cell growth factor receptor IC50 769.0 nM 10.1021/acs.jmedchem.8b01845
Homo sapiens Stem cell growth factor receptor IC50 5000.0 nM 10.1021/jm050231m
Homo sapiens Stem cell growth factor receptor IC50 5210.0 nM 10.1021/acs.jmedchem.8b01845
Homo sapiens Stem cell growth factor receptor IC50 9818.0 nM 10.1021/acs.jmedchem.6b00902
Homo sapiens Stem cell growth factor receptor IC50 10000.0 nM 10.1021/jm050231m
Homo sapiens Stem cell growth factor receptor IC50 100000.0 nM 10.1021/jm4004076
Homo sapiens Stem cell growth factor receptor IC50 nan None 10.1021/acs.jmedchem.7b00841
Homo sapiens Stem cell growth factor receptor Inhibition -47.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Stem cell growth factor receptor Inhibition 88.0 % 10.1038/nchembio760
Homo sapiens Stem cell growth factor receptor Inhibition nan % 10.1021/acs.jmedchem.6b00902
Homo sapiens Stem cell growth factor receptor Inhibition nan % 10.1021/acs.jmedchem.6b01290
Homo sapiens Stem cell growth factor receptor Inhibition nan % 10.1021/acs.jmedchem.9b00176
Homo sapiens Stem cell growth factor receptor Kd 12.59 nM 10.1021/acs.jmedchem.8b01925
Homo sapiens Stem cell growth factor receptor Kd 13.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd 14.0 nM 10.1016/j.ejmech.2011.02.057
Homo sapiens Stem cell growth factor receptor Kd 14.0 nM 10.1038/nbt1358
Homo sapiens Stem cell growth factor receptor Kd 14.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd 15.0 nM 10.1038/nbt1358
Homo sapiens Stem cell growth factor receptor Kd 15.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd 71.0 nM 10.1038/nbt1358
Homo sapiens Stem cell growth factor receptor Kd 91.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd 560.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd 820.0 nM 10.1016/j.ejmech.2011.02.057
Homo sapiens Stem cell growth factor receptor Kd 820.0 nM 10.1038/nbt1358
Homo sapiens Stem cell growth factor receptor Kd 830.0 nM 10.1038/nbt1068
Homo sapiens Stem cell growth factor receptor Kd 980.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd 2500.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd 2900.0 nM 10.1038/nbt1358
Homo sapiens Stem cell growth factor receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Stem cell growth factor receptor Ki 3981.07 nM None
Homo sapiens Structural maintenance of chromosomes protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens SU-DHL-1 IC50 96984.19 nM 10.6019/CHEMBL1201861
Homo sapiens SUP-T1 IC50 3829.07 nM 10.6019/CHEMBL1201861
Homo sapiens SW1088 Activity 0.98 None 10.1073/pnas.0707498104
Homo sapiens SW13 Activity 1.005 None 10.1073/pnas.0707498104
Homo sapiens SW1417 Activity 1.154 None 10.1073/pnas.0707498104
Homo sapiens SW1463 Activity 1.033 None 10.1073/pnas.0707498104
Homo sapiens SW1573 Activity 0.946 None 10.1073/pnas.0707498104
Homo sapiens SW1710 Activity 0.878 None 10.1073/pnas.0707498104
Homo sapiens SW1783 Activity 1.127 None 10.1073/pnas.0707498104
Homo sapiens SW1990 Activity 1.297 None 10.1073/pnas.0707498104
Homo sapiens SW48 Activity 1.043 None 10.1073/pnas.0707498104
Homo sapiens SW-620 Activity 1.159 None 10.1073/pnas.0707498104
Homo sapiens SW-620 GI -10.0 % 10.1016/j.ejmech.2018.10.062
Homo sapiens SW-620 GI50 23440.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens SW684 IC50 48269.51 nM 10.6019/CHEMBL1201861
Homo sapiens SW756 Activity 1.012 None 10.1073/pnas.0707498104
Homo sapiens SW780 Activity 0.911 None 10.1073/pnas.0707498104
Homo sapiens SW837 Activity 0.999 None 10.1073/pnas.0707498104
Homo sapiens SW872 IC50 67438.16 nM 10.6019/CHEMBL1201861
Homo sapiens SW900 Activity 1.016 None 10.1073/pnas.0707498104
Homo sapiens SW948 Activity 0.994 None 10.1073/pnas.0707498104
Homo sapiens SW 954 IC50 190507.2 nM 10.6019/CHEMBL1201861
Homo sapiens SW 962 IC50 122709.28 nM 10.6019/CHEMBL1201861
Homo sapiens SW982 IC50 250407.35 nM 10.6019/CHEMBL1201861
Homo sapiens T-24 Activity 1.044 None 10.1073/pnas.0707498104
Homo sapiens T47D Activity 1.022 None 10.1073/pnas.0707498104
Homo sapiens T47D GI50 19910.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens T84 Activity 1.011 None 10.1073/pnas.0707498104
Homo sapiens T98G Activity 0.864 None 10.1073/pnas.0707498104
Homo sapiens TALL-1 IC50 153835.68 nM 10.6019/CHEMBL1201861
Homo sapiens TCO-1 Activity 0.817 None 10.1073/pnas.0707498104
Homo sapiens TE-1 IC50 53945.54 nM 10.6019/CHEMBL1201861
Homo sapiens TE-10 IC50 106804.28 nM 10.6019/CHEMBL1201861
Homo sapiens TE-11 IC50 46653.04 nM 10.6019/CHEMBL1201861
Homo sapiens TE-12 IC50 234976.38 nM 10.6019/CHEMBL1201861
Homo sapiens TE-15 IC50 52255.65 nM 10.6019/CHEMBL1201861
Homo sapiens TE-441-T IC50 17288.58 nM 10.6019/CHEMBL1201861
Homo sapiens TE-5 IC50 211928.51 nM 10.6019/CHEMBL1201861
Homo sapiens TE-6 IC50 41279.75 nM 10.6019/CHEMBL1201861
Homo sapiens TE-8 IC50 202452.64 nM 10.6019/CHEMBL1201861
Homo sapiens TE-9 IC50 169102.49 nM 10.6019/CHEMBL1201861
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Ki 1584.89 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Ki 1584.89 nM None
Homo sapiens TF-1 IC50 13.0 nM 10.1021/jm201198w
Homo sapiens TF-1 IC50 5000.0 nM 10.1021/jm201198w
Homo sapiens TGBC1TKB IC50 130073.93 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC24TKB IC50 8340.52 nM 10.6019/CHEMBL1201861
Homo sapiens TGF-beta receptor type I Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens TGF-beta receptor type I Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens TGF-beta receptor type I Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TGF-beta receptor type II Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens TGF-beta receptor type II Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens TGF-beta receptor type II Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TGW Activity 1.021 None 10.1073/pnas.0707498104
Homo sapiens TGW IC50 318318.04 nM 10.6019/CHEMBL1201861
Homo sapiens THP-1 Activity nan None 10.1021/acs.jmedchem.2c00671
Homo sapiens THP-1 IC50 25000.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens THP-1 IC50 306657.66 nM 10.6019/CHEMBL1201861
Homo sapiens THP-1 Inhibition nan % 10.1021/acs.jmedchem.2c00671
Homo sapiens Thromboxane-A synthase IC50 198.0 nM None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens TK-10 GI -10.0 % 10.1016/j.ejmech.2018.10.062
Homo sapiens TK-10 GI50 26850.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens TK-10 IC50 178702.25 nM 10.6019/CHEMBL1201861
Homo sapiens TP53-regulating kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TRAF2- and NCK-interacting kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens TRAF2- and NCK-interacting kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens TRAF2- and NCK-interacting kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TRAF2- and NCK-interacting kinase Kd nan None 10.1038/nbt1068
Homo sapiens Transient receptor potential cation channel subfamily M member 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens TUR IC50 469386.25 nM 10.6019/CHEMBL1201861
Homo sapiens TYK-nu Activity 1.088 None 10.1073/pnas.0707498104
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine kinase non-receptor protein 2 Ki 3981.07 nM None
Homo sapiens Tyrosine-protein kinase ABL Activity 1.4 % 10.1021/jm101396q
Homo sapiens Tyrosine-protein kinase ABL GI50 260.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Tyrosine-protein kinase ABL GI50 10000.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Tyrosine-protein kinase ABL IC50 19.9 nM 10.1021/jm4004076
Homo sapiens Tyrosine-protein kinase ABL IC50 25.0 nM 10.1039/C1MD00175B
Homo sapiens Tyrosine-protein kinase ABL IC50 38.0 nM 10.1016/S0960-894X(96)00601-4
Homo sapiens Tyrosine-protein kinase ABL IC50 38.0 nM 10.1021/jm058225d
Homo sapiens Tyrosine-protein kinase ABL IC50 40.0 nM 10.1016/j.bmcl.2007.05.067
Homo sapiens Tyrosine-protein kinase ABL IC50 40.0 nM 10.1016/s0960-894x(03)00553-5
Homo sapiens Tyrosine-protein kinase ABL IC50 43.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Tyrosine-protein kinase ABL IC50 98.0 nM 10.1021/jm800188g
Homo sapiens Tyrosine-protein kinase ABL IC50 98.2 nM 10.1021/jm301581y
Homo sapiens Tyrosine-protein kinase ABL IC50 110.0 nM 10.1016/j.bmcl.2008.05.089
Homo sapiens Tyrosine-protein kinase ABL IC50 114.3 nM 10.1021/jm301581y
Homo sapiens Tyrosine-protein kinase ABL IC50 115.0 nM 10.1021/jm301581y
Homo sapiens Tyrosine-protein kinase ABL IC50 170.0 nM 10.1021/acs.jmedchem.5b01125
Homo sapiens Tyrosine-protein kinase ABL IC50 173.9 nM 10.1021/jm301581y
Homo sapiens Tyrosine-protein kinase ABL IC50 188.0 nM 10.1038/nchembio799
Homo sapiens Tyrosine-protein kinase ABL IC50 190.0 nM 10.1021/acs.jmedchem.1c01853
Homo sapiens Tyrosine-protein kinase ABL IC50 190.0 nM 10.1021/jm400099d
Homo sapiens Tyrosine-protein kinase ABL IC50 200.0 nM 10.1016/j.bmc.2015.02.026
Homo sapiens Tyrosine-protein kinase ABL IC50 200.0 nM 10.1016/j.bmc.2015.10.035
Homo sapiens Tyrosine-protein kinase ABL IC50 220.0 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens Tyrosine-protein kinase ABL IC50 223.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Tyrosine-protein kinase ABL IC50 234.0 nM 10.1016/j.bmcl.2011.09.127
Homo sapiens Tyrosine-protein kinase ABL IC50 250.0 nM 10.1021/jm400099d
Homo sapiens Tyrosine-protein kinase ABL IC50 250.0 nM 10.1038/nrd.2016.266
Homo sapiens Tyrosine-protein kinase ABL IC50 300.0 nM 10.1016/j.bmcl.2016.05.004
Homo sapiens Tyrosine-protein kinase ABL IC50 300.0 nM 10.1016/j.ejmech.2014.03.054
Homo sapiens Tyrosine-protein kinase ABL IC50 319.0 nM 10.1021/jm400099d
Homo sapiens Tyrosine-protein kinase ABL IC50 359.9 nM 10.1021/jm301581y
Homo sapiens Tyrosine-protein kinase ABL IC50 370.0 nM 10.1021/acs.jmedchem.1c01215
Homo sapiens Tyrosine-protein kinase ABL IC50 470.0 nM 10.1016/j.bmcl.2007.03.002
Homo sapiens Tyrosine-protein kinase ABL IC50 485.8 nM 10.1021/jm301581y
Homo sapiens Tyrosine-protein kinase ABL IC50 658.0 nM 10.1021/jm901132v
Homo sapiens Tyrosine-protein kinase ABL IC50 749.6 nM 10.1021/jm301581y
Homo sapiens Tyrosine-protein kinase ABL IC50 1000.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Tyrosine-protein kinase ABL IC50 1000.0 nM None
Homo sapiens Tyrosine-protein kinase ABL IC50 1100.0 nM 10.1016/j.ejmech.2020.112904
Homo sapiens Tyrosine-protein kinase ABL IC50 1100.0 nM 10.1021/jm800988r
Homo sapiens Tyrosine-protein kinase ABL IC50 1500.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Tyrosine-protein kinase ABL IC50 2700.0 nM 10.1021/jm101396q
Homo sapiens Tyrosine-protein kinase ABL IC50 5000.0 nM 10.1021/jm901132v
Homo sapiens Tyrosine-protein kinase ABL IC50 5155.0 nM 10.1021/jm301581y
Homo sapiens Tyrosine-protein kinase ABL IC50 10000.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens Tyrosine-protein kinase ABL IC50 10000.0 nM 10.1021/acs.jmedchem.1c01853
Homo sapiens Tyrosine-protein kinase ABL IC50 10000.0 nM 10.1021/jm8010542
Homo sapiens Tyrosine-protein kinase ABL IC50 74000.0 nM 10.1021/acs.jmedchem.5b01125
Homo sapiens Tyrosine-protein kinase ABL IC50 100000.0 nM 10.1021/jm800988r
Homo sapiens Tyrosine-protein kinase ABL Inhibition -88.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Tyrosine-protein kinase ABL Inhibition 12.5 % 10.1016/j.bmc.2019.115193
Homo sapiens Tyrosine-protein kinase ABL Inhibition 77.0 % 10.1016/j.ejmech.2018.12.012
Homo sapiens Tyrosine-protein kinase ABL Inhibition 95.0 % 10.1038/nchembio760
Homo sapiens Tyrosine-protein kinase ABL Inhibition 100.0 % 10.1016/j.bmcl.2011.09.127
Homo sapiens Tyrosine-protein kinase ABL Inhibition nan % 10.1016/j.ejmech.2014.03.054
Homo sapiens Tyrosine-protein kinase ABL Inhibition nan % 10.1021/acsmedchemlett.7b00084
Homo sapiens Tyrosine-protein kinase ABL Inhibition nan % 10.1021/jm301891t
Homo sapiens Tyrosine-protein kinase ABL Inhibition nan % 10.1021/jm4004076
Homo sapiens Tyrosine-protein kinase ABL Kd 1.0 nM 10.1021/acs.jmedchem.8b01925
Homo sapiens Tyrosine-protein kinase ABL Kd 1.1 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 1.8 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 2.2 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL Kd 2.5 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 5.9 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 8.3 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 8.5 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL Kd 12.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL Kd 14.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL Kd 21.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL Kd 21.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 24.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL Kd 35.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL Kd 44.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL Kd 44.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL Kd 44.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 62.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL Kd 65.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 77.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL Kd 92.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 106.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase ABL Kd 110.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL Kd 110.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 130.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 170.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 580.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 6200.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Ki 13.0 nM 10.1016/j.bmcl.2007.11.112
Homo sapiens Tyrosine-protein kinase ABL Ki 13.0 nM 10.1016/j.ejmech.2008.01.034
Homo sapiens Tyrosine-protein kinase ABL Ki 13.0 nM 10.1021/jm1012819
Homo sapiens Tyrosine-protein kinase ABL Ki 37.0 nM 10.1038/nchembio799
Homo sapiens Tyrosine-protein kinase ABL Ki 50.12 nM None
Homo sapiens Tyrosine-protein kinase ABL Ki 7000.0 nM 10.1038/nchembio799
Homo sapiens Tyrosine-protein kinase ABL Selectivity 0.0209 None 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL2 Activity 0.4 % 10.1021/jm101396q
Homo sapiens Tyrosine-protein kinase ABL2 IC50 272.0 nM 10.1038/nrd.2016.266
Homo sapiens Tyrosine-protein kinase ABL2 IC50 10000.0 nM 10.1021/acs.jmedchem.0c00502
Homo sapiens Tyrosine-protein kinase ABL2 Kd 6.0 nM 10.1021/jm101506n
Homo sapiens Tyrosine-protein kinase ABL2 Kd 10.0 nM 10.1016/j.ejmech.2020.112421
Homo sapiens Tyrosine-protein kinase ABL2 Kd 10.0 nM 10.1021/acs.jmedchem.8b01925
Homo sapiens Tyrosine-protein kinase ABL2 Kd 10.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL2 Kd 10.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL2 Kd 13.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL2 Kd 64.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase ABL2 Kd 500.0 nM 10.1021/jm101506n
Homo sapiens Tyrosine-protein kinase BLK Activity -3.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Tyrosine-protein kinase BLK Activity 0.8 % 10.1021/jm101396q
Homo sapiens Tyrosine-protein kinase BLK GI50 4100.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens Tyrosine-protein kinase BLK GI50 10000.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Tyrosine-protein kinase BLK Inhibition -3.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Tyrosine-protein kinase BLK Kd 520.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BLK Kd 520.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase BLK Ki 1000.0 nM None
Homo sapiens Tyrosine-protein kinase BMX Inhibition 27.0 % 10.1038/nchembio760
Homo sapiens Tyrosine-protein kinase BMX Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BMX Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase BMX Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BRK Inhibition 0.0 % 10.1016/j.ejmech.2018.12.012
Homo sapiens Tyrosine-protein kinase BRK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BRK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase BRK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase BRK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BRK Ki 2511.89 nM None
Homo sapiens Tyrosine-protein kinase BTK Activity nan None 10.1073/pnas.0702654104
Homo sapiens Tyrosine-protein kinase BTK Inhibition 0.0 % 10.1016/j.ejmech.2018.12.012
Homo sapiens Tyrosine-protein kinase BTK Inhibition 19.0 % 10.1038/nchembio760
Homo sapiens Tyrosine-protein kinase BTK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BTK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase BTK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase BTK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BTK Ki 5011.87 nM None
Homo sapiens Tyrosine-protein kinase CSK Inhibition 0.0 % 10.1016/j.ejmech.2018.12.012
Homo sapiens Tyrosine-protein kinase CSK Inhibition 2.0 % 10.1038/nchembio760
Homo sapiens Tyrosine-protein kinase CSK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase CSK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase CSK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase CSK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase CTK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase CTK Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase FER Activity 91.0 % 10.1021/jm101396q
Homo sapiens Tyrosine-protein kinase FER Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FER Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FER Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FER Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FER Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase FES Activity 78.0 % 10.1021/jm101396q
Homo sapiens Tyrosine-protein kinase FES Inhibition 62.0 % 10.1038/nchembio760
Homo sapiens Tyrosine-protein kinase FES Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FES Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FES Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FES Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase FGR Kd 2400.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FGR Kd 2400.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FGR Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FGR Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FRK Kd 1500.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FRK Kd 1500.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FRK Kd 3500.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FRK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FRK Ki 316.23 nM None
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Inhibition 0.0 % 10.1016/j.ejmech.2018.12.012
Homo sapiens Tyrosine-protein kinase FYN Kd 3100.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FYN Kd 3100.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FYN Kd 5500.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FYN Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FYN Ki 3981.07 nM None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase HCK GI50 9700.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens Tyrosine-protein kinase HCK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase HCK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase HCK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase HCK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase HCK Ki 3162.28 nM None
Homo sapiens Tyrosine-protein kinase ITK/TSK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ITK/TSK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ITK/TSK Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase JAK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase JAK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase JAK1 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase JAK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase JAK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase JAK2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase JAK2 Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase JAK3 Activity 100.0 % 10.1021/jm101396q
Homo sapiens Tyrosine-protein kinase JAK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase JAK3 Ki 3981.07 nM None
Homo sapiens Tyrosine-protein kinase LCK Activity 1.0 % 10.1021/jm101396q
Homo sapiens Tyrosine-protein kinase LCK GI50 500.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens Tyrosine-protein kinase LCK GI50 10000.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Tyrosine-protein kinase LCK IC50 160.0 nM 10.1021/jm900166t
Homo sapiens Tyrosine-protein kinase LCK IC50 320.0 nM 10.1016/j.bmcl.2008.05.089
Homo sapiens Tyrosine-protein kinase LCK IC50 320.0 nM 10.1021/jm800188g
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Inhibition 0.0 % 10.1016/j.ejmech.2018.12.012
Homo sapiens Tyrosine-protein kinase LCK Inhibition 95.0 % 10.1038/nchembio760
Homo sapiens Tyrosine-protein kinase LCK Kd 39.81 nM 10.1021/acs.jmedchem.8b01925
Homo sapiens Tyrosine-protein kinase LCK Kd 40.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase LCK Kd 40.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase LCK Kd 62.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase LCK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase LCK Ki 316.23 nM None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosine-protein kinase Lyn Activity 3.2 % 10.1021/jm101396q
Homo sapiens Tyrosine-protein kinase Lyn IC50 220.0 nM 10.1016/j.bmcl.2007.03.002
Homo sapiens Tyrosine-protein kinase Lyn Inhibition 0.0 % 10.1016/j.ejmech.2018.12.012
Homo sapiens Tyrosine-protein kinase Lyn Kd 890.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase Lyn Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase Lyn Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase Lyn Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase Lyn Ki 199.53 nM None
Homo sapiens Tyrosine-protein kinase receptor FLT3 Activity 76.0 % 10.1021/jm101396q
Homo sapiens Tyrosine-protein kinase receptor FLT3 IC50 131.0 nM 10.1021/acs.jmedchem.9b01229
Homo sapiens Tyrosine-protein kinase receptor FLT3 IC50 30000.0 nM 10.1021/jm020143r
Homo sapiens Tyrosine-protein kinase receptor FLT3 Inhibition -16.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Tyrosine-protein kinase receptor FLT3 Inhibition 72.0 % 10.1038/nchembio760
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 6300.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 10000.0 nM 10.1016/j.ejmech.2020.112421
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase receptor FLT3 Ki 2511.89 nM None
Homo sapiens Tyrosine-protein kinase receptor RET Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor RET Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor RET Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase receptor RET Ki 3162.28 nM None
Homo sapiens Tyrosine-protein kinase receptor Tie-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor Tie-1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Ki 2511.89 nM None
Homo sapiens Tyrosine-protein kinase receptor UFO Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Tyrosine-protein kinase receptor UFO Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor UFO Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor UFO Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase SRC GI50 2100.0 nM 10.1021/acs.jmedchem.5b01618
Homo sapiens Tyrosine-protein kinase SRC IC50 25000.0 nM 10.1021/jm800188g
Homo sapiens Tyrosine-protein kinase SRC IC50 100000.0 nM 10.1016/j.bmcl.2018.09.016
Homo sapiens Tyrosine-protein kinase SRC IC50 100000.0 nM 10.1016/S0960-894X(96)00601-4
Homo sapiens Tyrosine-protein kinase SRC IC50 100000.0 nM 10.1021/jm058225d
Homo sapiens Tyrosine-protein kinase SRC IC50 100000.0 nM 10.1039/C1MD00175B
Homo sapiens Tyrosine-protein kinase SRC Inhibition -30.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Tyrosine-protein kinase SRC Inhibition 0.0 % 10.1016/j.ejmech.2018.12.012
Homo sapiens Tyrosine-protein kinase SRC Inhibition 9.0 % 10.1038/nchembio760
Homo sapiens Tyrosine-protein kinase SRC Inhibition 97.12 % 10.1016/j.ejmech.2017.05.006
Homo sapiens Tyrosine-protein kinase SRC Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase SRC Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase SRC Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase SRC Kd 39810.72 nM 10.1021/acs.jmedchem.8b01925
Homo sapiens Tyrosine-protein kinase SRC Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase SRC Ki 3981.07 nM None
Homo sapiens Tyrosine-protein kinase SRC Ki 31000.0 nM 10.1016/j.bmcl.2007.11.112
Homo sapiens Tyrosine-protein kinase SRC Ki 31000.0 nM 10.1016/j.ejmech.2008.01.034
Homo sapiens Tyrosine-protein kinase SRC Ki 31000.0 nM 10.1021/jm1012819
Homo sapiens Tyrosine-protein kinase Srms Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase Srms Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase Srms Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase SYK IC50 5000.0 nM 10.1016/j.bmcl.2009.02.049
Homo sapiens Tyrosine-protein kinase SYK IC50 10000.0 nM 10.1038/nchembio799
Homo sapiens Tyrosine-protein kinase SYK Inhibition 45.0 % 10.1038/nchembio760
Homo sapiens Tyrosine-protein kinase SYK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase SYK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase SYK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase SYK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase SYK Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase SYK Ki 5000.0 nM 10.1016/j.bmcl.2017.11.002
Homo sapiens Tyrosine-protein kinase SYK Ki 5000.0 nM 10.1021/jm201271b
Homo sapiens Tyrosine-protein kinase TEC Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TEC Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TEC Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase TIE-2 Inhibition 66.0 % 10.1038/nchembio760
Homo sapiens Tyrosine-protein kinase TIE-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TIE-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TIE-2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase TXK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TXK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TYK2 Kd 8700.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TYK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TYK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TYK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase TYK2 Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase YES Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase YES Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase YES Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase YES Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase YES Potency 27403.8 nM None
Homo sapiens Tyrosine-protein kinase ZAP-70 Inhibition 29.0 % 10.1038/nchembio760
Homo sapiens Tyrosine-protein kinase ZAP-70 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ZAP-70 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 11220.2 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 17782.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 31622.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 35481.3 nM None
Homo sapiens Tyrosyl-tRNA synthetase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens U-251 GI 10.6 % 10.1016/j.ejmech.2018.10.062
Homo sapiens U-251 GI50 17990.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens U-266 IC50 413642.06 nM 10.6019/CHEMBL1201861
Homo sapiens U2OS IC50 27150.0 nM 10.1021/acs.jmedchem.1c01732
Homo sapiens U373 MG Activity 1.019 None 10.1073/pnas.0707498104
Homo sapiens U5 small nuclear ribonucleoprotein 200 kDa helicase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens U-698-M IC50 197954.46 nM 10.6019/CHEMBL1201861
Homo sapiens U-87 MG IC50 178630.25 nM 10.6019/CHEMBL1201861
Homo sapiens U-937 GI50 10000.0 nM 10.1016/j.ejmech.2018.10.007
Homo sapiens U-937 IC50 1000.0 nM 10.1021/acs.jmedchem.1c00082
Homo sapiens U-937 IC50 12440.0 nM 10.1016/j.bmcl.2016.10.007
Homo sapiens U-937 IC50 14000.0 nM 10.1016/j.bmcl.2005.11.042
Homo sapiens U-937 IC50 16590.0 nM 10.1016/j.ejmech.2022.114731
Homo sapiens U-937 IC50 19000.0 nM 10.1016/j.bmcl.2015.07.065
Homo sapiens UACC-257 GI 2.8 % 10.1016/j.ejmech.2018.10.062
Homo sapiens UACC-257 GI50 21130.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens UACC-257 IC50 113496.16 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-62 GI 7.7 % 10.1016/j.ejmech.2018.10.062
Homo sapiens UACC-62 GI50 19010.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens UACC-812 Activity 1.377 None 10.1073/pnas.0707498104
Homo sapiens UACC-812 IC50 71160.93 nM 10.6019/CHEMBL1201861
Homo sapiens UMC-11 Activity 1.023 None 10.1073/pnas.0707498104
Homo sapiens UMP-CMP kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens UMUC3 Activity 0.967 None 10.1073/pnas.0707498104
Homo sapiens Uncharacterized aarF domain-containing protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized aarF domain-containing protein kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Uncharacterized aarF domain-containing protein kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Uncharacterized aarF domain-containing protein kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized protein FLJ45252 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens UO-31 Activity 0.893 None 10.1073/pnas.0707498104
Homo sapiens UO-31 GI 7.6 % 10.1016/j.ejmech.2018.10.062
Homo sapiens UO-31 GI50 22340.0 nM 10.1016/j.ejmech.2020.112756
Homo sapiens VA-ES-BJ IC50 99405.65 nM 10.6019/CHEMBL1201861
Homo sapiens Vascular endothelial growth factor receptor 1 Activity -10.0 % 10.1016/j.ejmech.2019.111780
Homo sapiens Vascular endothelial growth factor receptor 1 Activity 78.0 % 10.1021/jm101396q
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Inhibition -42.0 % 10.1016/j.ejmech.2018.04.029
Homo sapiens Vascular endothelial growth factor receptor 1 Inhibition -10.0 % 10.1016/j.bmc.2017.08.039
Homo sapiens Vascular endothelial growth factor receptor 1 Inhibition 0.0 % 10.1038/nchembio760
Homo sapiens Vascular endothelial growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Vascular endothelial growth factor receptor 1 Ki 3162.28 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 2 Activity 57.0 % 10.1021/jm101396q
Homo sapiens Vascular endothelial growth factor receptor 2 GI50 10000.0 nM 10.1016/j.ejmech.2018.03.003
Homo sapiens Vascular endothelial growth factor receptor 2 GI50 10000.0 nM 10.1021/acs.jmedchem.6b01290
Homo sapiens Vascular endothelial growth factor receptor 2 GI50 10000.0 nM 10.1021/acs.jmedchem.8b00938
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 25000.0 nM 10.1016/j.bmcl.2008.05.089
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 25000.0 nM 10.1021/jm800188g
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 25800.0 nM 10.1021/jm800988r
Homo sapiens Vascular endothelial growth factor receptor 2 IC50 27186.0 nM 10.1021/acs.jmedchem.7b00468
Homo sapiens Vascular endothelial growth factor receptor 2 Inhibition 22.0 % 10.1038/nchembio760
Homo sapiens Vascular endothelial growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Vascular endothelial growth factor receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Vascular endothelial growth factor receptor 2 Ki 3162.28 nM None
Homo sapiens Vascular endothelial growth factor receptor 3 Activity 85.0 % 10.1021/jm101396q
Homo sapiens Vascular endothelial growth factor receptor 3 Inhibition 79.0 % 10.1038/nchembio760
Homo sapiens Vascular endothelial growth factor receptor 3 Inhibition 89.6 % 10.1016/j.ejmech.2020.112946
Homo sapiens Vascular endothelial growth factor receptor 3 Kd 10000.0 nM 10.1016/j.ejmech.2020.112421
Homo sapiens Vascular endothelial growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Vascular endothelial growth factor receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Vascular endothelial growth factor receptor 3 Ki 6309.57 nM None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens VM-CUB-1 Activity 0.998 None 10.1073/pnas.0707498104
Homo sapiens VMRC-LCP Activity 0.963 None 10.1073/pnas.0707498104
Homo sapiens VMRC-MELG Activity 1.016 None 10.1073/pnas.0707498104
Homo sapiens VMRC-RCZ Activity 1.008 None 10.1073/pnas.0707498104
Homo sapiens Wee1-like protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens WI-38 VA13 Activity 1.034 None 10.1073/pnas.0707498104
Homo sapiens WiDr Activity 0.918 None 10.1073/pnas.0707498104
Homo sapiens WSU-NHL IC50 228021.06 nM 10.6019/CHEMBL1201861
Homo sapiens YAPC Activity 1.133 None 10.1073/pnas.0707498104
Homo sapiens YKG-1 Activity 0.898 None 10.1073/pnas.0707498104
Homo sapiens YT IC50 38520.94 nM 10.6019/CHEMBL1201861
Homo sapiens ZR-75-1 Activity 0.919 None 10.1073/pnas.0707498104
Homo sapiens ZR-75-30 Activity 0.963 None 10.1073/pnas.0707498104
Klebsiella pneumoniae Klebsiella pneumoniae MIC 20000.0 nM 10.6019/CHEMBL4513161
Middle East respiratory syndrome-related coronavirus Middle East respiratory syndrome-related coronavirus EC50 2100.0 nM 10.1021/acs.jmedchem.1c00335
Middle East respiratory syndrome-related coronavirus Middle East respiratory syndrome-related coronavirus EC50 9230.0 nM 10.1021/acs.jmedchem.1c00335
Mus musculus BaF3 Activity 0.0 % 10.1021/acs.jmedchem.8b00938
Mus musculus BaF3 Activity 3.36 g 10.1016/j.ejmech.2018.10.007
Mus musculus BaF3 GI50 4686.0 nM 10.1021/acs.jmedchem.7b00468
Mus musculus BaF3 GI50 10000.0 nM 10.1016/j.ejmech.2018.03.003
Mus musculus BaF3 GI50 10000.0 nM 10.1016/j.ejmech.2018.10.007
Mus musculus BaF3 GI50 10000.0 nM 10.1021/acs.jmedchem.6b00200
Mus musculus BaF3 GI50 10000.0 nM 10.1021/acs.jmedchem.6b00902
Mus musculus BaF3 GI50 10000.0 nM 10.1021/acs.jmedchem.8b00938
Mus musculus BaF3 GI50 10000.0 nM 10.1021/acs.jmedchem.9b00280
Mus musculus BaF3 IC50 100.0 nM 10.1021/acs.jmedchem.1c00082
Mus musculus BaF3 IC50 230.0 nM 10.1016/j.ejmech.2022.114425
Mus musculus BaF3 IC50 7100.0 nM 10.1021/jm060380k
Mus musculus BaF3 IC50 9100.0 nM 10.1021/jm060380k
Mus musculus BaF3 IC50 10000.0 nM 10.1016/j.ejmech.2022.114425
Mus musculus BaF3 Ratio IC50 163.0 None 10.1021/acs.jmedchem.5b01125
Mus musculus BaF3 TGI 34.0 % 10.1021/acs.jmedchem.8b00938
Mus musculus BaF3 TGI 43.0 % 10.1021/acs.jmedchem.8b00938
Mus musculus BaF3 TGI nan None 10.1021/acs.jmedchem.7b00468
Mus musculus BCR/ABL1 IC50 38.0 nM 10.1016/j.bmcl.2018.09.016
Mus musculus Carbonic anhydrase 15 Ki 78.0 nM 10.1016/j.bmcl.2009.06.002
Mus musculus Carbonic anhydrase XIII Ki 7450.0 nM 10.1016/j.bmcl.2009.06.002
Mus musculus Delta(24)-sterol reductase Inhibition nan % 10.1021/acs.jmedchem.5b01696
Mus musculus Dual specificity mitogen-activated protein kinase kinase 4 Inhibition 0.0 % 10.1038/nchembio760
Mus musculus Liver CL 18.0 mL.min-1.g-1 10.1021/acs.jmedchem.7b00841
Mus musculus Mast/stem cell growth factor receptor Kit GI50 350.0 nM 10.1021/acs.jmedchem.9b00280
Mus musculus Mus musculus Activity 81.5 % 10.1021/acs.jmedchem.5b01106
Mus musculus Mus musculus Activity nan None 10.1016/j.ejmech.2018.03.003
Mus musculus Mus musculus Activity nan None 10.1021/acs.jmedchem.9b01283
Mus musculus Mus musculus Inhibition 50.0 % 10.1021/acs.jmedchem.9b01283
Mus musculus Mus musculus Inhibition 88.0 % 10.1016/j.bmcl.2008.05.089
Mus musculus Mus musculus Inhibition nan % 10.1021/acs.jmedchem.9b01283
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus Nuclear receptor ROR-gamma Potency 11220.2 nM None
Mus musculus Plasma Ratio AUC 0.8 None 10.1124/dmd.110.034629
Mus musculus Platelet-derived growth factor receptor IC50 300.0 nM 10.1016/j.ejmech.2007.09.021
Mus musculus Platelet-derived growth factor receptor beta IC50 50.0 nM 10.1016/j.bmcl.2018.09.016
Mus musculus Serine/threonine-protein kinase MST2 Kd nan None 10.1038/nbt1068
Mus musculus Tyrosine-protein kinase ABL IC50 10.8 nM 10.1016/j.bmc.2010.05.063
Mus musculus Tyrosine-protein kinase ABL IC50 730.0 nM 10.1016/j.bmcl.2017.09.048
Mus musculus Tyrosine-protein kinase ABL IC50 20030.0 nM 10.1016/j.bmcl.2017.09.048
Mus musculus Tyrosine-protein kinase ABL Inhibition 25.0 % 10.1038/nchembio760
Mus musculus Tyrosine-protein kinase ABL Inhibition nan % 10.1021/jm301581y
Mus musculus ULK3 kinase Kd nan None 10.1038/nbt1068
Mycobacterium tuberculosis Serine/threonine-protein kinase pknB Kd 10000.0 nM 10.1038/nbt.1990
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Photinus pyralis Luciferin 4-monooxygenase Potency 12817.8 nM None
Plasmodium falciparum Calcium-dependent protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Plasmodium falciparum Plasmodium falciparum Potency 4256.2 nM None
Plasmodium falciparum Plasmodium falciparum Potency 5358.2 nM None
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog Kd 10000.0 nM 10.1038/nbt.1990
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 20000.0 nM 10.6019/CHEMBL4513161
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus AMP-activated protein kinase, alpha-2 subunit Inhibition 1.0 % 10.1038/nchembio760
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Heme oxygenase 1 IC50 100000.0 nM 10.1016/j.ejmech.2018.09.048
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Liver IC50 nan None 10.1002/hep.27206
Rattus norvegicus Liver microsomes CL 56.6 mL.min-1.g-1 10.1016/j.bmc.2013.03.038
Rattus norvegicus Liver microsomes Drug metabolism 1.8 % 10.1016/j.bmc.2013.03.038
Rattus norvegicus Liver microsomes Drug metabolism 7.9 % 10.1016/j.bmc.2013.03.038
Rattus norvegicus Liver microsomes Stability 77.2 % 10.1016/j.bmc.2013.03.038
Rattus norvegicus Liver microsomes T1/2 0.4167 hr 10.1016/j.bmc.2013.03.038
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Platelet-derived growth factor receptor beta IC50 162.0 nM 10.1021/acs.jmedchem.6b00703
Rattus norvegicus Rattus norvegicus ALB 42000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 354.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 357.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 359.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 362.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 404.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 449.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 48.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 49.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 53.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 55.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 77.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 86.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 80.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 83.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 89.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 113.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 119.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AUC 16.73 ng.hr.mL-1 10.1016/j.bmc.2013.03.038
Rattus norvegicus Rattus norvegicus AUC 702.42 ng.hr.mL-1 10.1016/j.bmc.2013.03.038
Rattus norvegicus Rattus norvegicus AUC 855.6 ng.hr.mL-1 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus AUC 868.84 ng.hr.mL-1 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus AUC 971.44 ng.hr.mL-1 10.1016/j.bmc.2013.03.038
Rattus norvegicus Rattus norvegicus AUC 6462.53 ng.hr.mL-1 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus AUC 6647.67 ng.hr.mL-1 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus BASO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 3.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 146.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 153.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 156.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 160.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 173.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 100.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 105.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 496.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 600.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 613.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 646.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 680.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 686.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 198.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 205.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 251.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 276.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 325.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 404.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CL 17.0 mL.min-1.kg-1 10.1016/j.bmc.2013.03.038
Rattus norvegicus Rattus norvegicus CL 19.85 mL.min-1.kg-1 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus CL 27.88 mL.min-1.kg-1 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus Cmax 1076.33 nM 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus Cmax 1108.14 nM 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus CO2 26330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 27330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 1.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.1 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 37.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 64.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 72.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 119.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 151.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOS 248.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus F 76.51 % 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus GLUC 1403.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1540.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1620.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1635.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1650.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1720.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 32.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.07 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 33.27 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 34.93 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 35.35 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 36.35 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 122700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 125300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 127300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 130000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 132200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 135800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 128.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 135.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 144.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 163.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 183.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 254.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 6282.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 6343.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 9025.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 10599.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 11284.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYM 12977.83 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 89.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 90.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 91.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.32 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.83 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 23.88 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.03 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.43 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 24.53 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 372000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 374000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 374200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 377000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 377300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 385300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 62.42 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.53 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.83 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 63.85 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.03 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 64.93 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 0.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 19.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 25.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 102.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONO 109.5 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MRT 5.4 hr 10.1016/j.bmc.2013.03.038
Rattus norvegicus Rattus norvegicus MRT(t) 3.094 hr 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus MRT(t) 7.454 hr 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus NEUTLE 7.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 8.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 9.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 568.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 653.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 844.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1012.33 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1137.17 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTSG 1139.67 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 107.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 110.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 111.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 117.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 121.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1004670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1102330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1206670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1243330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1333330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1337670.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.66 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.69 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.96 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.99 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.28 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 59700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 60300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61200.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Ratio AUC 2.4 % 10.1016/j.bmc.2013.03.038
Rattus norvegicus Rattus norvegicus RBC 5010000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5210000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5450000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5540000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 5820000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBCNUC 0.0 /100WBC 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 141.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 143.57 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.5 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.03 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.7 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus T1/2 2.213 hr 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus T1/2 4.262 hr 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus T1/2 4.6 hr 10.1016/j.bmc.2013.03.038
Rattus norvegicus Rattus norvegicus Tissue Severity Score nan None 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Tmax 0.017 hr 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus Tmax 6.667 hr 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus URATE 7.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 9.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 13.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 13.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 14.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 17.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Vd 3.696 L.kg-1 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus Vd 10.31 L.kg-1 10.1016/j.ejmech.2018.03.003
Rattus norvegicus Rattus norvegicus Vdss 5.5 L.kg-1 10.1016/j.bmc.2013.03.038
Rattus norvegicus Rattus norvegicus WBC 7030.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 7130.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9930.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 12330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 14380.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Tubulin alpha-1 chain Kd 10000.0 nM 10.1038/nbt1358
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 8.19 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.06765 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 130.0 nM 10.1021/acs.jmedchem.1c00335
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 3240.0 nM 10.1016/j.bmc.2020.115757
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 10964.78 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 11000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 21877.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 21900.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 1.38 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index -0.262 None 10.1101/2020.04.03.023846
Severe acute respiratory syndrome-related coronavirus SARS-CoV EC50 2100.0 nM 10.1021/acs.jmedchem.1c00302
Severe acute respiratory syndrome-related coronavirus SARS-CoV IC50 9823.0 nM 10.1021/acs.jmedchem.1c00335
Staphylococcus aureus Staphylococcus aureus MIC 20000.0 nM 10.6019/CHEMBL4513161
Trypanosoma cruzi Cruzipain IC50 207000.0 nM 10.1021/jm100254w
Trypanosoma cruzi Cruzipain IC50 297000.0 nM 10.1021/jm100254w
Trypanosoma cruzi Cruzipain Potency 2511.9 nM None
Trypanosoma cruzi Cruzipain Potency 3162.3 nM None
Trypanosoma cruzi Trypanosoma cruzi EC50 9000.0 nM 10.1128/aac.01777-09
None ADMET Activity 0.932 None 10.1073/pnas.0707498104
None ADMET Activity 0.997 None 10.1073/pnas.0707498104
None ADMET Activity nan None 10.1021/acs.jmedchem.1c01732
None ADMET AUC 781.1 None 10.1021/acs.jmedchem.1c01853
None ADMET AUC 24800.0 ng.hr.mL-1 10.1016/j.ejmech.2019.112029
None ADMET Biotransformation nan None 10.1038/s41586-019-1291-3
None ADMET CC50 20530.0 nM 10.1016/j.bmcl.2016.01.068
None ADMET CL 3.3 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET Cmax 3.849 nM 10.1016/j.ejmech.2019.112029
None ADMET Cmax 1865.81 nM 10.1016/j.ejmech.2019.112029
None ADMET Cmax 2183.87 nM 10.1016/j.ejmech.2019.112029
None ADMET Cp 3.7 ng/ml 10.1016/j.ejmech.2019.112029
None ADMET Drug recovery 56.6 % 10.1016/j.ejmech.2021.113232
None ADMET Drug recovery 69.9 % 10.1016/j.ejmech.2021.113232
None ADMET Drug uptake 5.0 % 10.1021/jm801315b
None ADMET Drug uptake 305.5 uM 10.1021/acs.jmedchem.6b00703
None ADMET EC50 32000.0 nM 10.1128/aac.01777-09
None ADMET F 98.3 % 10.1016/j.ejmech.2019.112029
None ADMET Fu 0.037 None 10.1021/acs.jmedchem.0c02011
None ADMET Fu 0.045 None 10.1021/acs.jmedchem.0c02011
None ADMET GI 21.8 % 10.1016/j.bmc.2013.07.026
None ADMET GI 68.2 % 10.1016/j.bmc.2013.07.026
None ADMET GI 84.2 % 10.1016/j.bmc.2013.07.026
None ADMET GI 84.6 % 10.1016/j.bmc.2013.07.026
None ADMET GI50 6700.0 nM 10.1021/acs.jmedchem.5b01618
None ADMET GI50 10000.0 nM 10.1021/acs.jmedchem.5b01618
None ADMET GI50 10000.0 nM 10.1021/acs.jmedchem.6b00200
None ADMET GI50 20000.0 nM 10.1021/jm4004076
None ADMET IC50 112.0 nM 10.1038/nchembio760
None ADMET IC50 190.0 nM 10.1038/nchembio760
None ADMET IC50 10000.0 nM 10.1021/jm301891t
None ADMET IC50 10000.0 nM 10.1038/nchembio760
None ADMET IC50 13500.0 nM 10.1021/jm301581y
None ADMET IC50 20000.0 nM 10.1038/nchembio760
None ADMET K(p,uu,brain) 0.041 None 10.1021/acs.jmedchem.0c02011
None ADMET MRT 20.0 hr 10.1124/dmd.108.020479
None ADMET Papp 3.7 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 3.8 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 5.2 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 5.6 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 5.8 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 5.9 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 6.5 10^-6 cm/s 10.1016/j.ejmech.2021.113232
None ADMET Papp 7.5 ucm/s 10.1124/dmd.110.034629
None ADMET Papp 7.69 10^-6 cm/s 10.1016/j.ejmech.2021.113232
None ADMET permeability 20.0 10'-6 cm/s 10.1021/acs.jmedchem.0c00407
None ADMET PPB 93.67 % 10.6019/CHEMBL3301361
None ADMET PPB 95.0 % 10.1016/j.ejmech.2019.112029
None ADMET PPB 96.9 % 10.1021/acs.jmedchem.0c00407
None ADMET PPB 97.2 % 10.6019/CHEMBL3301361
None ADMET Ratio -7.0 None 10.1124/dmd.110.034629
None ADMET Ratio 0.182 None 10.1021/acs.jmedchem.0c02011
None ADMET Ratio 0.7 None 10.1124/dmd.110.034629
None ADMET Ratio 0.84 None 10.1016/j.ejmech.2021.113232
None ADMET Ratio 1.0 None 10.1124/dmd.110.034629
None ADMET Ratio 1.3 None 10.1124/dmd.110.034629
None ADMET Ratio 1.6 None 10.1021/acs.jmedchem.0c00407
None ADMET Ratio 2.1 None 10.1124/dmd.110.034629
None ADMET Ratio 6.0 None 10.1124/dmd.110.034629
None ADMET Ratio 15.0 None 10.1124/dmd.110.034629
None ADMET Ratio 21.0 None 10.1124/dmd.110.034629
None ADMET Ratio 27.0 None 10.1124/dmd.110.034629
None ADMET Ratio 41.0 None 10.1124/dmd.110.034629
None ADMET Ratio 43.0 None 10.1124/dmd.110.034629
None ADMET Ratio 49.0 None 10.1124/dmd.110.034629
None ADMET Ratio 59.0 None 10.1124/dmd.110.034629
None ADMET Ratio CC50/IC50 0.34 None 10.1016/j.bmcl.2015.07.065
None ADMET Ratio CC50/IC50 0.44 None 10.1016/j.bmcl.2015.07.065
None ADMET Ratio CC50/IC50 7.6 None 10.1016/j.bmcl.2015.07.065
None ADMET Ratio CC50/IC50 140.0 None 10.1016/j.bmcl.2015.07.065
None ADMET Stability 50.0 % 10.1021/acs.jmedchem.0c00407
None ADMET T1/2 0.6333 hr 10.1021/acs.jmedchem.0c00407
None ADMET T1/2 17.0 hr 10.1016/j.ejmech.2019.112029
None ADMET T1/2 22.0 hr 10.1124/dmd.108.020479
None ADMET Vdss 0.001 L.kg-1 10.1016/j.ejmech.2019.112029
None ADMET Vdss 3.9 L.kg-1 10.1124/dmd.108.020479
None BC1 cell line IC50 190024.69 nM 10.6019/CHEMBL1201861
None COLO Activity 0.785 None 10.1073/pnas.0707498104
None COLO Activity 0.904 None 10.1073/pnas.0707498104
None COLO Activity 0.913 None 10.1073/pnas.0707498104
None COLO Activity 0.921 None 10.1073/pnas.0707498104
None COLO Activity 0.937 None 10.1073/pnas.0707498104
None COLO Activity 0.946 None 10.1073/pnas.0707498104
None COLO Activity 0.958 None 10.1073/pnas.0707498104
None COLO Activity 0.973 None 10.1073/pnas.0707498104
None COLO Activity 1.011 None 10.1073/pnas.0707498104
None COLO Activity 1.07 None 10.1073/pnas.0707498104
None COLO Activity 1.081 None 10.1073/pnas.0707498104
None COLO Activity 1.138 None 10.1073/pnas.0707498104
None COLO Activity 1.166 None 10.1073/pnas.0707498104
None COLO Activity 1.269 None 10.1073/pnas.0707498104
None Erythrocyte HC10 20.0 uM 10.6019/CHEMBL4513161
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 4.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None Molecular identity unknown Activity nan None 10.1021/acs.jmedchem.6b01290
None Molecular identity unknown IC50 30.0 nM 10.1016/j.ejmech.2019.112029
None Molecular identity unknown IC50 188.0 nM 10.1016/j.ejmech.2019.112029
None NON-PROTEIN TARGET Activity 0.44 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.638 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.713 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.734 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.755 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.798 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.801 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.832 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.833 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.836 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.838 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.839 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.849 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.852 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.863 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.877 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.881 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.884 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.891 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.894 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.897 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.898 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.9 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.903 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.904 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.905 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.908 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.911 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.913 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.916 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.917 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.919 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.923 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.927 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.928 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.929 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.93 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.934 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.935 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.942 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.945 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.946 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.947 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.952 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.953 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.956 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.957 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.959 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.961 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.965 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.966 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.967 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.968 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.97 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.972 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.974 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.975 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.977 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.978 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.979 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.98 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.982 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.983 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.986 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.988 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.989 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.99 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.991 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.992 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.993 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.995 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.998 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 0.999 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.002 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.003 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.005 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.008 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.009 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.01 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.012 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.013 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.017 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.018 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.019 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.02 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.022 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.023 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.024 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.026 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.028 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.029 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.032 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.033 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.034 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.036 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.037 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.045 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.046 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.048 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.049 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.051 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.052 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.053 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.055 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.057 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.058 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.059 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.06 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.064 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.065 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.066 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.068 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.07 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.071 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.072 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.074 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.075 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.076 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.077 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.078 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.079 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.081 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.082 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.086 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.087 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.089 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.09 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.092 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.093 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.094 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.099 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.103 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.104 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.109 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.114 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.115 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.116 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.117 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.122 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.13 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.142 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.143 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.146 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.152 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.153 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.156 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.164 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.166 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.183 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.187 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.193 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.2 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.234 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.237 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.254 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.262 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.281 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.282 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.335 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.336 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.427 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.429 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 1.485 None 10.1073/pnas.0707498104
None NON-PROTEIN TARGET Activity 20.0 % 10.1021/jm201198w
None NON-PROTEIN TARGET Activity 30.0 % 10.1021/jm201198w
None NON-PROTEIN TARGET Activity 40.0 % 10.1021/jm201198w
None NON-PROTEIN TARGET Activity 47.0 % 10.1016/j.bmcl.2015.07.065
None NON-PROTEIN TARGET Activity 58.7 % 10.1016/j.bmcl.2015.07.065
None NON-PROTEIN TARGET Activity 65.1 % 10.1016/j.bmcl.2015.07.065
None NON-PROTEIN TARGET Activity 71.1 % 10.1016/j.bmcl.2015.07.065
None NON-PROTEIN TARGET Activity 99.0 % 10.1016/j.bmcl.2016.09.041
None NON-PROTEIN TARGET Activity nan None 10.1021/acs.jmedchem.6b00703
None NON-PROTEIN TARGET Activity nan None 10.1021/jm201198w
None NON-PROTEIN TARGET Activity nan None 10.1021/jm301581y
None NON-PROTEIN TARGET EC50 nan None 10.1021/acs.jmedchem.6b00087
None NON-PROTEIN TARGET Fu 0.05 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET GI nan None 10.1021/jm4004076
None NON-PROTEIN TARGET GI50 8.0 nM 10.1021/acs.jmedchem.6b00200
None NON-PROTEIN TARGET GI50 8.0 nM 10.1021/acs.jmedchem.6b01290
None NON-PROTEIN TARGET GI50 14.0 nM 10.1021/acs.jmedchem.6b00200
None NON-PROTEIN TARGET GI50 14.0 nM 10.1021/acs.jmedchem.6b01290
None NON-PROTEIN TARGET GI50 60.0 nM 10.1021/acs.jmedchem.5b01712
None NON-PROTEIN TARGET GI50 74.0 nM 10.1021/acs.jmedchem.6b00200
None NON-PROTEIN TARGET GI50 74.0 nM 10.1021/acs.jmedchem.6b01290
None NON-PROTEIN TARGET GI50 100.0 nM 10.1021/acs.jmedchem.5b01712
None NON-PROTEIN TARGET GI50 160.0 nM 10.1021/acs.jmedchem.5b01618
None NON-PROTEIN TARGET GI50 160.0 nM 10.1021/acs.jmedchem.6b00200
None NON-PROTEIN TARGET GI50 163.0 nM 10.1021/acs.jmedchem.6b01290
None NON-PROTEIN TARGET GI50 240.0 nM 10.1021/acs.jmedchem.5b01618
None NON-PROTEIN TARGET GI50 260.0 nM 10.1021/acs.jmedchem.5b01712
None NON-PROTEIN TARGET GI50 267.0 nM 10.1021/acs.jmedchem.6b01290
None NON-PROTEIN TARGET GI50 430.0 nM 10.1021/acs.jmedchem.5b01712
None NON-PROTEIN TARGET GI50 10000.0 nM 10.1021/acs.jmedchem.5b01618
None NON-PROTEIN TARGET GI50 10000.0 nM 10.1021/acs.jmedchem.6b00200
None NON-PROTEIN TARGET GI50 10000.0 nM 10.1021/acs.jmedchem.6b01290
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.4 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 5.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 100.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET IC50 27.0 nM 10.1038/nchembio760
None NON-PROTEIN TARGET IC50 30.0 nM 10.1016/j.bmcl.2016.01.068
None NON-PROTEIN TARGET IC50 39.0 nM 10.1016/j.bmc.2010.08.026
None NON-PROTEIN TARGET IC50 55.0 nM 10.1038/nchembio760
None NON-PROTEIN TARGET IC50 88.0 nM 10.1038/nchembio760
None NON-PROTEIN TARGET IC50 89.0 nM 10.1021/acs.jmedchem.5b01125
None NON-PROTEIN TARGET IC50 92.0 nM 10.1021/jm301891t
None NON-PROTEIN TARGET IC50 100.0 nM 10.1021/jm201198w
None NON-PROTEIN TARGET IC50 108.0 nM 10.1016/j.bmc.2010.08.026
None NON-PROTEIN TARGET IC50 110.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 111.0 nM 10.1038/nchembio760
None NON-PROTEIN TARGET IC50 129.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 190.0 nM 10.1038/nchembio760
None NON-PROTEIN TARGET IC50 240.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 257.0 nM 10.1038/nchembio760
None NON-PROTEIN TARGET IC50 280.0 nM 10.1016/j.bmc.2010.01.052
None NON-PROTEIN TARGET IC50 310.0 nM 10.1016/j.ejmech.2016.05.017
None NON-PROTEIN TARGET IC50 333.0 nM 10.1016/j.bmcl.2009.10.085
None NON-PROTEIN TARGET IC50 337.0 nM 10.1016/j.bmcl.2011.02.029
None NON-PROTEIN TARGET IC50 339.0 nM 10.1038/nchembio760
None NON-PROTEIN TARGET IC50 350.0 nM 10.1038/nchembio0309-144
None NON-PROTEIN TARGET IC50 358.0 nM 10.1016/j.bmc.2010.08.026
None NON-PROTEIN TARGET IC50 362.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 393.0 nM 10.1038/nchembio760
None NON-PROTEIN TARGET IC50 424.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 500.0 nM 10.1021/jm201198w
None NON-PROTEIN TARGET IC50 500.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 590.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 678.0 nM 10.1016/j.bmc.2010.08.026
None NON-PROTEIN TARGET IC50 960.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 962.0 nM 10.1038/nchembio760
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1016/j.bmcl.2015.07.006
None NON-PROTEIN TARGET IC50 1000.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 1100.0 nM 10.1016/j.bmcl.2015.07.065
None NON-PROTEIN TARGET IC50 1444.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 1600.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 1700.0 nM 10.1021/jm900424a
None NON-PROTEIN TARGET IC50 1834.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 1863.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 2377.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 2547.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 2951.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 3005.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 3300.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 3600.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 3763.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 4650.0 nM 10.1021/acs.jmedchem.5b01841
None NON-PROTEIN TARGET IC50 4790.0 nM 10.1021/jm301891t
None NON-PROTEIN TARGET IC50 5200.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 5400.0 nM 10.1016/j.bmc.2010.01.052
None NON-PROTEIN TARGET IC50 5600.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 8615.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 9200.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 9459.0 nM 10.1016/j.bmc.2010.08.026
None NON-PROTEIN TARGET IC50 9500.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 10000.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 10000.0 nM 10.1038/nchembio760
None NON-PROTEIN TARGET IC50 10000.0 nM None
None NON-PROTEIN TARGET IC50 11100.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 12000.0 nM 10.1021/jm800988r
None NON-PROTEIN TARGET IC50 12200.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 12500.0 nM 10.1021/jm301581y
None NON-PROTEIN TARGET IC50 12589.25 nM 10.1021/jm800988r
None NON-PROTEIN TARGET IC50 14500.0 nM 10.1021/acs.jmedchem.5b01125
None NON-PROTEIN TARGET IC50 16700.0 nM 10.1016/j.bmcl.2016.01.068
None NON-PROTEIN TARGET IC50 17000.0 nM 10.1021/jm500413g
None NON-PROTEIN TARGET IC50 17083.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 18520.0 nM 10.1021/jm301188x
None NON-PROTEIN TARGET IC50 18700.0 nM 10.1021/jm900424a
None NON-PROTEIN TARGET IC50 19000.0 nM 10.1021/jm800988r
None NON-PROTEIN TARGET IC50 19952.62 nM 10.1021/jm800988r
None NON-PROTEIN TARGET IC50 20000.0 nM 10.1016/j.ejmech.2014.03.054
None NON-PROTEIN TARGET IC50 37000.0 nM 10.1021/jm800988r
None NON-PROTEIN TARGET IC50 38000.0 nM 10.1021/jm800988r
None NON-PROTEIN TARGET IC50 39810.72 nM 10.1021/jm800988r
None NON-PROTEIN TARGET IC50 nan None 10.1016/j.ejmech.2015.12.023
None NON-PROTEIN TARGET IC50 nan None 10.1021/jm201198w
None NON-PROTEIN TARGET TGI 31.9 % 10.1021/acs.jmedchem.6b01290
None NON-PROTEIN TARGET TGI nan None 10.1021/jm301581y
None No relevant target Activity 100.0 uM 10.1021/jm100254w
None No relevant target Activity 118.4 nm 10.1021/jm100254w
None No relevant target LogD -0.1 None 10.1021/acs.jmedchem.0c00407
None No relevant target LogD 2.4 None 10.1021/acs.jmedchem.0c00407
None No relevant target LogD7.4 2.5 None 10.6019/CHEMBL3301361
None No relevant target LogP 1.2 None 10.1016/j.bmc.2010.01.053
None No relevant target LogP 1.99 None 10.1016/S0960-894X(96)00601-4
None No relevant target LogP 3.0 None 10.1016/j.ejmech.2009.12.043
None No relevant target pKa 8.07 None 10.1016/S0960-894X(96)00601-4
None No relevant target Solubility 2.0 ug.mL-1 10.1021/acs.jmedchem.0c00407
None No relevant target Solubility 122.0 ug.mL-1 10.1021/acs.jmedchem.0c00407
None No relevant target Solubility 22900.0 nM 10.6019/CHEMBL3301361
None No relevant target Solubility 30700.0 nM 10.1021/acs.jmedchem.1c01215
None Nucleic Acid Delta Tm 0.1 degrees C 10.1021/jm900424a
None Nucleic Acid Delta Tm 0.2 degrees C 10.1021/jm900424a
None Unchecked Activity 0.41 g 10.1021/acs.jmedchem.9b00176
None Unchecked Activity 61.13 % None
None Unchecked Activity nan None 10.1016/j.ejmech.2017.02.051
None Unchecked Activity nan None 10.1021/acs.jmedchem.6b00902
None Unchecked Activity nan None 10.1021/acs.jmedchem.6b01290
None Unchecked Delta Tm 0.1 degrees C 10.1016/j.bmc.2018.04.050
None Unchecked EC50 200.0 nM 10.1073/pnas.0707498104
None Unchecked EC50 380300.0 nM None
None Unchecked EC50 nan None 10.1073/pnas.0707498104
None Unchecked GI50 10.0 nM 10.1021/acs.jmedchem.6b00902
None Unchecked GI50 115.0 nM 10.1021/acs.jmedchem.9b00280
None Unchecked GI50 174.0 nM 10.1021/acs.jmedchem.9b00280
None Unchecked GI50 337.0 nM 10.1021/acs.jmedchem.9b00280
None Unchecked GI50 608.0 nM 10.1021/acs.jmedchem.9b00280
None Unchecked GI50 625.0 nM 10.1021/acs.jmedchem.6b01290
None Unchecked GI50 850.0 nM 10.1021/acs.jmedchem.6b01290
None Unchecked GI50 855.0 nM 10.1021/acs.jmedchem.5b01618
None Unchecked GI50 1790.0 nM 10.1021/acs.jmedchem.6b01290
None Unchecked GI50 1930.0 nM 10.1021/acs.jmedchem.5b01618
None Unchecked GI50 2160.0 nM 10.1021/acs.jmedchem.6b01290
None Unchecked GI50 4080.0 nM 10.1021/acs.jmedchem.9b00280
None Unchecked GI50 6986.0 nM 10.1021/acs.jmedchem.7b00468
None Unchecked GI50 10000.0 nM 10.1021/acs.jmedchem.5b01618
None Unchecked GI50 10000.0 nM 10.1021/acs.jmedchem.6b01290
None Unchecked GI50 10000.0 nM 10.1021/acs.jmedchem.7b00468
None Unchecked GI50 10000.0 nM 10.1021/acs.jmedchem.9b00176
None Unchecked GI50 10000.0 nM 10.1021/acs.jmedchem.9b00280
None Unchecked GI50 nan None 10.1021/acs.jmedchem.7b00841
None Unchecked Hepatotoxicity (acute) 3.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 1.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 34.93 nM 10.1021/acs.jmedchem.1c00246
None Unchecked IC50 39.0 nM 10.1021/jm901132v
None Unchecked IC50 100.0 nM 10.1021/jm901132v
None Unchecked IC50 112.0 nM 10.1073/pnas.0707498104
None Unchecked IC50 216.8 nM 10.1016/j.bmcl.2012.06.044
None Unchecked IC50 221.5 nM 10.1016/j.bmcl.2019.126758
None Unchecked IC50 345.5 nM 10.1016/j.bmcl.2019.126758
None Unchecked IC50 1340.0 nM 10.1016/j.bmcl.2021.127964
None Unchecked IC50 1700.0 nM 10.1016/j.bmc.2018.04.050
None Unchecked IC50 1800.0 nM 10.1016/j.bmcl.2015.10.030
None Unchecked IC50 2706.0 nM 10.1016/j.bmcl.2019.126758
None Unchecked IC50 3257.0 nM 10.1016/j.bmcl.2019.126758
None Unchecked IC50 3500.0 nM 10.1016/j.bmcl.2015.10.030
None Unchecked IC50 8437.0 nM 10.1016/j.bmc.2010.01.056
None Unchecked IC50 13690.0 nM 10.1016/j.bmcl.2008.07.111
None Unchecked IC50 14000.0 nM 10.1021/jm800188g
None Unchecked IC50 19800.0 nM 10.1016/j.bmc.2018.04.050
None Unchecked IC50 25000.0 nM 10.1016/j.bmc.2018.04.050
None Unchecked IC50 87500.0 nM 10.1021/jm800988r
None Unchecked IC50 100000.0 nM 10.1016/j.bmcl.2021.128116
None Unchecked IC50 nan None 10.1016/j.ejmech.2018.04.029
None Unchecked IC50 nan None 10.1021/jm3001339
None Unchecked IC50 nan None None
None Unchecked Inhibition 30.0 % 10.1016/j.ejmech.2020.112946
None Unchecked Inhibition nan % 10.1016/j.bmcl.2015.10.030
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.2c00671
None Unchecked Inhibition nan % 10.1021/jm4004076
None Unchecked K 2.32 uM 10.1021/acs.jmedchem.1c00335
None Unchecked Kd 1000.0 nM 10.1021/acs.jmedchem.8b01925
None Unchecked Kd 3783.0 nM 10.1126/science.aan4368
None Unchecked Kd 30000.0 nM 10.1126/science.aan4368
None Unchecked Ki 3.08e-05 nM 10.1016/j.ejmech.2009.10.044
None Unchecked Ki nan None None
None Unchecked logIC50 3.92 None 10.1016/j.bmc.2010.01.056
None Unchecked MTC 25.0 uM 10.1021/acs.jmedchem.1c01853
None Unchecked Potency 3981.1 nM None
None Unchecked Potency 7569.9 nM None
None Unchecked Potency 10582.1 nM None
None Unchecked Potency 14381.8 nM None
None Unchecked Potency 20931.0 nM None
None Unchecked Potency 23485.0 nM None
None Unchecked Potency 26350.6 nM None
None Unchecked Potency 29565.9 nM None
None Unchecked Potency 33173.4 nM None
None Unchecked Potency 37221.2 nM None
None Unchecked Potency 58991.7 nM None
None Unchecked Ratio 0.176 None 10.1093/toxsci/kft176
None Unchecked Ratio 0.52 None 10.1021/jm301302s
None Unchecked Ratio 3.1 None 10.1016/j.bmcl.2003.12.015
None Unchecked Ratio 3.65 None 10.1021/jm301302s
None Unchecked Ratio 4.09 None 10.1021/acs.jmedchem.1c00246
None Unchecked Ratio 4.56 None 10.1021/jm301302s
None Unchecked Ratio EC50 3.6 None 10.1128/aac.01777-09
None Unchecked RatioGI50 80000.0 None 10.1016/j.ejmech.2019.111663
None Unchecked Ratio IC50 1.61 None 10.1016/j.bmcl.2020.127638
None Unchecked Ratio IC50 2.0 None 10.1016/j.bmcl.2008.05.089
None Unchecked Ratio IC50 5.0 None 10.1016/j.bmcl.2008.05.089
None Unchecked Ratio IC50 5.0 None 10.1021/jm301302s
None Unchecked Ratio IC50 6.6 None 10.1016/j.bmc.2010.01.056
None Unchecked Ratio IC50 30.0 None None
None Unchecked Ratio IC50 41.45 None 10.1016/j.ejmech.2022.114425
None Unchecked Ratio IC50 236.0 None 10.1016/j.bmcl.2008.07.111
None Unchecked Ratio IC50 244.0 None 10.1016/j.bmcl.2008.05.089
None Unchecked Ratio IC50 435.0 None 10.1021/acs.jmedchem.5b01125
None Unchecked Ratio IC50 481.0 None 10.1016/j.bmcl.2008.05.089
None Unchecked Ratio Ki 20.0 None 10.1016/j.bmc.2010.04.024

Metabolism Information