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1-(1H-indol-3-yl)-3-{[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxy}propan-2-amine

AlkaPlorer ID: AK073262

Synonym: None

IUPAC Name: (2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine

Structure

SMILES: CC1=C2C=C(C3=CN=CC(OC[C@@H](N)CC4=CNC5=CC=CC=C45)=C3)C=CC2=NN1

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InChI: InChI=1S/C24H23N5O/c1-15-22-10-16(6-7-24(22)29-28-15)17-9-20(13-26-11-17)30-14-19(25)8-18-12-27-23-5-3-2-4-21(18)23/h2-7,9-13,19,27H,8,14,25H2,1H3,(H,28,29)/t19-/m0/s1

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InChIKey: YWTBGJGMTBHQTM-IBGZPJMESA-N

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Reference

PubChem CID: 10172943

CAS: 552325-16-3

NPASS: NPC180504

Source

Species Genus Family Order Class Phylum Kingdom Domain
Huperzia serrata Huperzia Lycopodiaceae Lycopodiales Lycopodiopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 397.482

TPSA？: 92.61

MolLogP？: 4.363420000000001

Number of H-Donors: 3

Number of H-Acceptors: 4

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Canis lupus familiaris Canis familiaris Activity 60.0 mmHg 10.1021/jm0701019
Gallus gallus Tyrosine-protein kinase SRC Activity 86.0 % 10.1042/bj20070797
Gallus gallus Tyrosine-protein kinase SRC Activity 91.0 % 10.1042/bj20070797
Hepatitis B virus Hepatitis B virus Inhibition 50.0 % 10.1021/acs.jmedchem.0c01467
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Activity 79.0 % 10.1042/bj20070797
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Activity 88.0 % 10.1042/bj20070797
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Inhibition 88.0 % 10.1038/nchembio.183
Homo sapiens 697 IC50 32.81 nM 10.6019/CHEMBL1201861
Homo sapiens 8-MG-BA IC50 163.01 nM 10.6019/CHEMBL1201861
Homo sapiens A101D IC50 132.65 nM 10.6019/CHEMBL1201861
Homo sapiens A253 cell line IC50 392.62 nM 10.6019/CHEMBL1201861
Homo sapiens A388 IC50 84.33 nM 10.6019/CHEMBL1201861
Homo sapiens A3-KAW IC50 196.23 nM 10.6019/CHEMBL1201861
Homo sapiens A498 IC50 68046.0 nM 10.6019/CHEMBL1201861
Homo sapiens A4-Fuk IC50 102.54 nM 10.6019/CHEMBL1201861
Homo sapiens A704 IC50 260.96 nM 10.6019/CHEMBL1201861
Homo sapiens ACN IC50 908.85 nM 10.6019/CHEMBL1201861
Homo sapiens Activin receptor type-1B Inhibition 0.0 % 10.1038/nchembio.183
Homo sapiens ALK tyrosine kinase receptor Inhibition 17.0 % 10.1038/nchembio.183
Homo sapiens ALL-PO IC50 796.71 nM 10.6019/CHEMBL1201861
Homo sapiens AM-38 IC50 18566.32 nM 10.6019/CHEMBL1201861
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Inhibition 57.0 % 10.1038/nchembio.183
Homo sapiens ARH-77 IC50 297.72 nM 10.6019/CHEMBL1201861
Homo sapiens Ataxin-2 Potency 11220.2 nM None
Homo sapiens ATN-1 IC50 1923.05 nM 10.6019/CHEMBL1201861
Homo sapiens BB30-HNC IC50 219.63 nM 10.6019/CHEMBL1201861
Homo sapiens BB49-HNC IC50 3026.19 nM 10.6019/CHEMBL1201861
Homo sapiens BB65-RCC IC50 597.14 nM 10.6019/CHEMBL1201861
Homo sapiens BC-3 IC50 342.35 nM 10.6019/CHEMBL1201861
Homo sapiens BE-13 IC50 502.24 nM 10.6019/CHEMBL1201861
Homo sapiens Becker IC50 303.17 nM 10.6019/CHEMBL1201861
Homo sapiens Beta-adrenergic receptor kinase 2 Inhibition 1.0 % 10.1038/nchembio.183
Homo sapiens BL-41 IC50 96.35 nM 10.6019/CHEMBL1201861
Homo sapiens BL-70 IC50 57.03 nM 10.6019/CHEMBL1201861
Homo sapiens BOKU IC50 3092.02 nM 10.6019/CHEMBL1201861
Homo sapiens BR serine/threonine-protein kinase 1 Inhibition 24.0 % 10.1038/nchembio.183
Homo sapiens BR serine/threonine-protein kinase 2 Activity 79.0 % 10.1042/bj20070797
Homo sapiens BR serine/threonine-protein kinase 2 Activity 88.0 % 10.1042/bj20070797
Homo sapiens BT-474 IC50 584.44 nM 10.6019/CHEMBL1201861
Homo sapiens BV-173 IC50 268.78 nM 10.6019/CHEMBL1201861
Homo sapiens C2BBe1 IC50 2073.22 nM 10.6019/CHEMBL1201861
Homo sapiens C8166 IC50 52733.03 nM 10.6019/CHEMBL1201861
Homo sapiens CA46 IC50 2065.98 nM 10.6019/CHEMBL1201861
Homo sapiens CAL-148 IC50 88.25 nM 10.6019/CHEMBL1201861
Homo sapiens Calu-6 IC50 137.42 nM 10.6019/CHEMBL1201861
Homo sapiens CaM kinase I alpha Activity 77.0 % 10.1042/bj20070797
Homo sapiens CaM kinase I alpha Activity 89.0 % 10.1042/bj20070797
Homo sapiens CaM kinase I delta Inhibition 29.0 % 10.1038/nchembio.183
Homo sapiens CaM kinase II alpha Inhibition 80.0 % 10.1038/nchembio.183
Homo sapiens CaM kinase II beta Inhibition 65.0 % 10.1038/nchembio.183
Homo sapiens CaM kinase II delta Inhibition 90.0 % 10.1038/nchembio.183
Homo sapiens CaM kinase IV Inhibition 9.0 % 10.1038/nchembio.183
Homo sapiens CaM-kinase kinase alpha Activity 112.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase alpha Activity 117.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Activity 63.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Activity 83.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Activity 3.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Activity 26.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Inhibition 99.0 % 10.1038/nchembio.183
Homo sapiens CAS-1 IC50 2796.38 nM 10.6019/CHEMBL1201861
Homo sapiens Casein kinase I alpha Inhibition 18.0 % 10.1038/nchembio.183
Homo sapiens Casein kinase I delta Activity 74.0 % 10.1042/bj20070797
Homo sapiens Casein kinase I delta Activity 95.0 % 10.1042/bj20070797
Homo sapiens Casein kinase I delta Inhibition 32.0 % 10.1038/nchembio.183
Homo sapiens Casein kinase I epsilon Inhibition 42.0 % 10.1038/nchembio.183
Homo sapiens Casein kinase I gamma 1 Inhibition 62.0 % 10.1038/nchembio.183
Homo sapiens Casein kinase I gamma 2 Inhibition 81.0 % 10.1038/nchembio.183
Homo sapiens Casein kinase II Activity 90.0 % 10.1042/bj20070797
Homo sapiens Casein kinase II Activity 96.0 % 10.1042/bj20070797
Homo sapiens Casein kinase II alpha Inhibition 2.0 % 10.1038/nchembio.183
Homo sapiens Casein kinase II alpha (prime) Inhibition 6.0 % 10.1038/nchembio.183
Homo sapiens Casein kinase I isoform gamma-3 Inhibition 57.0 % 10.1038/nchembio.183
Homo sapiens CCRF-CEM IC50 143.88 nM 10.6019/CHEMBL1201861
Homo sapiens CESS IC50 191.24 nM 10.6019/CHEMBL1201861
Homo sapiens cGMP-dependent protein kinase 1 beta Inhibition 99.0 % 10.1038/nchembio.183
Homo sapiens cGMP-dependent protein kinase 2 Inhibition 96.0 % 10.1038/nchembio.183
Homo sapiens CGTH-W-1 IC50 245.66 nM 10.6019/CHEMBL1201861
Homo sapiens CHP-126 IC50 267.36 nM 10.6019/CHEMBL1201861
Homo sapiens c-Jun N-terminal kinase 1 Activity 89.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 1 Activity 90.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 2 Activity 78.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 2 Activity 94.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 3 Activity 81.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 3 Activity 86.0 % 10.1042/bj20070797
Homo sapiens CMK IC50 275.47 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-320-HSR IC50 937.47 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-668 IC50 405.44 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-684 IC50 79.47 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-800 IC50 217220.72 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-824 IC50 3301.5 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-829 IC50 14469.99 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L279 IC50 569.81 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L88 IC50 737.55 nM 10.6019/CHEMBL1201861
Homo sapiens CP66-MEL IC50 459.12 nM 10.6019/CHEMBL1201861
Homo sapiens CP67-MEL IC50 312.73 nM 10.6019/CHEMBL1201861
Homo sapiens CPC-N IC50 303.67 nM 10.6019/CHEMBL1201861
Homo sapiens CTB-1 IC50 508.66 nM 10.6019/CHEMBL1201861
Homo sapiens CTV-1 IC50 323.24 nM 10.6019/CHEMBL1201861
Homo sapiens CW-2 IC50 145549.47 nM 10.6019/CHEMBL1201861
Homo sapiens Cyclin-dependent kinase 1/cyclin B Inhibition 81.0 % 10.1038/nchembio.183
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 31.0 % 10.1042/bj20070797
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 82.0 % 10.1042/bj20070797
Homo sapiens Cyclin-dependent kinase 2/cyclin A Inhibition 85.0 % 10.1038/nchembio.183
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Inhibition 85.0 % 10.1038/nchembio.183
Homo sapiens D-247MG IC50 973.71 nM 10.6019/CHEMBL1201861
Homo sapiens D-263MG IC50 4108.51 nM 10.6019/CHEMBL1201861
Homo sapiens D283 Med IC50 96497.78 nM 10.6019/CHEMBL1201861
Homo sapiens D-336MG IC50 421.44 nM 10.6019/CHEMBL1201861
Homo sapiens D-502MG IC50 3279.65 nM 10.6019/CHEMBL1201861
Homo sapiens Daudi IC50 354.63 nM 10.6019/CHEMBL1201861
Homo sapiens DB IC50 374.8 nM 10.6019/CHEMBL1201861
Homo sapiens Death-associated protein kinase 3 Inhibition 32.0 % 10.1038/nchembio.183
Homo sapiens DEL IC50 231.45 nM 10.6019/CHEMBL1201861
Homo sapiens DG-75 IC50 545.85 nM 10.6019/CHEMBL1201861
Homo sapiens DJM-1 IC50 331.16 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-114 IC50 983.34 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-153 IC50 668.56 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-79 IC50 750.46 nM 10.6019/CHEMBL1201861
Homo sapiens DOHH-2 IC50 240.02 nM 10.6019/CHEMBL1201861
Homo sapiens DSH1 IC50 360.93 nM 10.6019/CHEMBL1201861
Homo sapiens DU-4475 IC50 800.63 nM 10.6019/CHEMBL1201861
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Activity 67.0 % 10.1042/bj20070797
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Activity 84.0 % 10.1042/bj20070797
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Inhibition 42.0 % 10.1038/nchembio.183
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Inhibition 42.0 % 10.1038/nchembio.183
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Inhibition 40.0 % 10.1038/nchembio.183
Homo sapiens Dual specificity protein kinase CLK2 Inhibition 97.0 % 10.1038/nchembio.183
Homo sapiens Dual specificity protein kinase CLK3 Inhibition 92.0 % 10.1038/nchembio.183
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 7.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 10.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Inhibition 102.0 % 10.1038/nchembio.183
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Inhibition 99.0 % 10.1038/nchembio.183
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 26.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 79.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Activity 8.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Activity 41.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Inhibition 96.0 % 10.1038/nchembio.183
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 4 Inhibition 30.0 % 10.1038/nchembio.183
Homo sapiens Dual specificty protein kinase CLK1 Inhibition 99.0 % 10.1038/nchembio.183
Homo sapiens EB2 IC50 9151.13 nM 10.6019/CHEMBL1201861
Homo sapiens EB-3 IC50 334.39 nM 10.6019/CHEMBL1201861
Homo sapiens ECC4 IC50 29058.82 nM 10.6019/CHEMBL1201861
Homo sapiens EC-GI-10 IC50 2457.56 nM 10.6019/CHEMBL1201861
Homo sapiens EHEB IC50 402.1 nM 10.6019/CHEMBL1201861
Homo sapiens EKVX IC50 2565.65 nM 10.6019/CHEMBL1201861
Homo sapiens EM-2 IC50 583.37 nM 10.6019/CHEMBL1201861
Homo sapiens EOL1 IC50 164.89 nM 10.6019/CHEMBL1201861
Homo sapiens Ephrin type-A receptor 1 Inhibition -1.0 % 10.1038/nchembio.183
Homo sapiens Ephrin type-A receptor 2 Inhibition 8.0 % 10.1038/nchembio.183
Homo sapiens Ephrin type-A receptor 3 Inhibition -5.0 % 10.1038/nchembio.183
Homo sapiens Ephrin type-A receptor 4 Inhibition -4.0 % 10.1038/nchembio.183
Homo sapiens Ephrin type-A receptor 5 Inhibition 1.0 % 10.1038/nchembio.183
Homo sapiens Ephrin type-A receptor 8 Inhibition 3.0 % 10.1038/nchembio.183
Homo sapiens Ephrin type-B receptor 1 Inhibition 1.0 % 10.1038/nchembio.183
Homo sapiens Ephrin type-B receptor 2 Inhibition 1.0 % 10.1038/nchembio.183
Homo sapiens Ephrin type-B receptor 3 Inhibition 2.0 % 10.1038/nchembio.183
Homo sapiens Ephrin type-B receptor 4 Inhibition 16.0 % 10.1038/nchembio.183
Homo sapiens Epidermal growth factor receptor erbB1 Inhibition -5.0 % 10.1038/nchembio.183
Homo sapiens Epidermal growth factor receptor erbB1 Inhibition -3.0 % 10.1038/nchembio.183
Homo sapiens Epidermal growth factor receptor erbB1 Inhibition 6.0 % 10.1038/nchembio.183
Homo sapiens ES1 IC50 739.09 nM 10.6019/CHEMBL1201861
Homo sapiens ES3 IC50 3472.04 nM 10.6019/CHEMBL1201861
Homo sapiens ES4 IC50 37.74 nM 10.6019/CHEMBL1201861
Homo sapiens ES5 IC50 8012.92 nM 10.6019/CHEMBL1201861
Homo sapiens ES6 IC50 91.53 nM 10.6019/CHEMBL1201861
Homo sapiens ES7 IC50 77766.68 nM 10.6019/CHEMBL1201861
Homo sapiens ES8 IC50 151.13 nM 10.6019/CHEMBL1201861
Homo sapiens ETK-1 IC50 101.06 nM 10.6019/CHEMBL1201861
Homo sapiens EVSA-T IC50 220.18 nM 10.6019/CHEMBL1201861
Homo sapiens EW-1 IC50 221.38 nM 10.6019/CHEMBL1201861
Homo sapiens EW-11 IC50 205927.26 nM 10.6019/CHEMBL1201861
Homo sapiens EW-12 IC50 238637.58 nM 10.6019/CHEMBL1201861
Homo sapiens EW-13 IC50 2666.58 nM 10.6019/CHEMBL1201861
Homo sapiens EW-16 IC50 215.98 nM 10.6019/CHEMBL1201861
Homo sapiens EW-18 IC50 205742.83 nM 10.6019/CHEMBL1201861
Homo sapiens EW-24 IC50 837.09 nM 10.6019/CHEMBL1201861
Homo sapiens EW-3 IC50 1113.46 nM 10.6019/CHEMBL1201861
Homo sapiens Fibroblast growth factor receptor 1 Inhibition 14.0 % 10.1038/nchembio.183
Homo sapiens Fibroblast growth factor receptor 2 Inhibition 3.0 % 10.1038/nchembio.183
Homo sapiens Fibroblast growth factor receptor 3 Inhibition -1.0 % 10.1038/nchembio.183
Homo sapiens Fibroblast growth factor receptor 3 Inhibition 8.0 % 10.1038/nchembio.183
Homo sapiens Fibroblast growth factor receptor 4 Inhibition -2.0 % 10.1038/nchembio.183
Homo sapiens Flap endonuclease 1 Potency 44668.4 nM None
Homo sapiens GAK IC50 16810.39 nM 10.6019/CHEMBL1201861
Homo sapiens GB-1 IC50 199.12 nM 10.6019/CHEMBL1201861
Homo sapiens GCIY IC50 261.31 nM 10.6019/CHEMBL1201861
Homo sapiens GDM-1 IC50 9550.22 nM 10.6019/CHEMBL1201861
Homo sapiens Geminin Potency 580.5 nM None
Homo sapiens Geminin Potency 2310.9 nM None
Homo sapiens GI-1 IC50 187.46 nM 10.6019/CHEMBL1201861
Homo sapiens GI-ME-N IC50 278.39 nM 10.6019/CHEMBL1201861
Homo sapiens Glucagon-like peptide 1 receptor Potency 501.2 nM None
Homo sapiens Glycogen synthase kinase-3 alpha Inhibition 84.0 % 10.1038/nchembio.183
Homo sapiens Glycogen synthase kinase-3 beta Activity 33.0 % 10.1042/bj20070797
Homo sapiens Glycogen synthase kinase-3 beta Activity 81.0 % 10.1042/bj20070797
Homo sapiens Glycogen synthase kinase-3 beta Inhibition 92.0 % 10.1038/nchembio.183
Homo sapiens Glycoprotein hormones alpha chain Potency 2511.9 nM None
Homo sapiens GOTO IC50 366.19 nM 10.6019/CHEMBL1201861
Homo sapiens G-protein coupled receptor kinase 2 Inhibition 4.0 % 10.1038/nchembio.183
Homo sapiens G protein-coupled receptor kinase 4 Inhibition 72.0 % 10.1038/nchembio.183
Homo sapiens G protein-coupled receptor kinase 5 Inhibition 46.0 % 10.1038/nchembio.183
Homo sapiens G protein-coupled receptor kinase 6 Inhibition 78.0 % 10.1038/nchembio.183
Homo sapiens G protein-coupled receptor kinase 7 Inhibition 102.0 % 10.1038/nchembio.183
Homo sapiens GR-ST IC50 448.37 nM 10.6019/CHEMBL1201861
Homo sapiens GT3TKB IC50 3144.33 nM 10.6019/CHEMBL1201861
Homo sapiens HAL-01 IC50 10952.71 nM 10.6019/CHEMBL1201861
Homo sapiens HC-1 IC50 207.78 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1187 IC50 1130.72 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1599 IC50 162.28 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2157 IC50 560.63 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2218 IC50 266.09 nM 10.6019/CHEMBL1201861
Homo sapiens HCE-4 IC50 104.44 nM 10.6019/CHEMBL1201861
Homo sapiens HCE-T IC50 450.8 nM 10.6019/CHEMBL1201861
Homo sapiens HDLM-2 IC50 3166.35 nM 10.6019/CHEMBL1201861
Homo sapiens HD-MY-Z IC50 1774.7 nM 10.6019/CHEMBL1201861
Homo sapiens HEL IC50 422.46 nM 10.6019/CHEMBL1201861
Homo sapiens Hepatocyte growth factor receptor Inhibition 5.0 % 10.1038/nchembio.183
Homo sapiens Hepatocyte growth factor receptor Inhibition 12.0 % 10.1038/nchembio.183
Homo sapiens HepG2 Activity nan None 10.1021/acs.jmedchem.0c01467
Homo sapiens HepG2 Potency 4466.8 nM None
Homo sapiens HH IC50 223.23 nM 10.6019/CHEMBL1201861
Homo sapiens HL-60 IC50 500.33 nM 10.6019/CHEMBL1201861
Homo sapiens Homeodomain-interacting protein kinase 1 Inhibition 68.0 % 10.1038/nchembio.183
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 24.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 73.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 71.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 90.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 4 Inhibition 75.0 % 10.1038/nchembio.183
Homo sapiens HOP-62 IC50 140.35 nM 10.6019/CHEMBL1201861
Homo sapiens HT IC50 373.34 nM 10.6019/CHEMBL1201861
Homo sapiens HT-144 IC50 152.59 nM 10.6019/CHEMBL1201861
Homo sapiens HuTu80 IC50 113.71 nM 10.6019/CHEMBL1201861
Homo sapiens IA-LM IC50 200.0 nM 10.6019/CHEMBL1201861
Homo sapiens IM-9 IC50 35702.51 nM 10.6019/CHEMBL1201861
Homo sapiens IMR-5 IC50 599.66 nM 10.6019/CHEMBL1201861
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Activity 89.0 % 10.1042/bj20070797
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Activity 93.0 % 10.1042/bj20070797
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Inhibition 11.0 % 10.1038/nchembio.183
Homo sapiens Insulin-like growth factor I receptor Inhibition 5.0 % 10.1038/nchembio.183
Homo sapiens Insulin receptor Inhibition -3.0 % 10.1038/nchembio.183
Homo sapiens Insulin receptor-related protein Inhibition 1.0 % 10.1038/nchembio.183
Homo sapiens Interleukin-1 receptor-associated kinase 4 Inhibition 53.0 % 10.1038/nchembio.183
Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Potency 18356.4 nM None
Homo sapiens IST-MEL1 IC50 446.62 nM 10.6019/CHEMBL1201861
Homo sapiens IST-MES1 IC50 1780.12 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL1 IC50 434.08 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL2 IC50 193.69 nM 10.6019/CHEMBL1201861
Homo sapiens JAR IC50 155.61 nM 10.6019/CHEMBL1201861
Homo sapiens JIYOYE IC50 188.45 nM 10.6019/CHEMBL1201861
Homo sapiens J-RT3-T3-5 IC50 184.59 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-2 IC50 3047.89 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-3 IC50 1478.98 nM 10.6019/CHEMBL1201861
Homo sapiens K052 IC50 88780.94 nM 10.6019/CHEMBL1201861
Homo sapiens K5 IC50 427.64 nM 10.6019/CHEMBL1201861
Homo sapiens K562 IC50 385.36 nM 10.6019/CHEMBL1201861
Homo sapiens KALS-1 IC50 203.07 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-299 IC50 472.74 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-422 IC50 294.33 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-45 IC50 295.7 nM 10.6019/CHEMBL1201861
Homo sapiens Kasumi 1 IC50 66173.3 nM 10.6019/CHEMBL1201861
Homo sapiens KE-37 IC50 110.19 nM 10.6019/CHEMBL1201861
Homo sapiens KG-1 IC50 3758.02 nM 10.6019/CHEMBL1201861
Homo sapiens KGN IC50 117.69 nM 10.6019/CHEMBL1201861
Homo sapiens KINGS-1 IC50 291.91 nM 10.6019/CHEMBL1201861
Homo sapiens KLE IC50 226.05 nM 10.6019/CHEMBL1201861
Homo sapiens KM12 IC50 140.89 nM 10.6019/CHEMBL1201861
Homo sapiens KM-H2 IC50 1779.71 nM 10.6019/CHEMBL1201861
Homo sapiens KMOE-2 IC50 1489.95 nM 10.6019/CHEMBL1201861
Homo sapiens KMS-12-PE IC50 47462.6 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-42 IC50 248.2 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-81-FD IC50 1799.56 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-RT-BM-1 IC50 910.79 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-YS IC50 4863.3 nM 10.6019/CHEMBL1201861
Homo sapiens KS-1 IC50 53.54 nM 10.6019/CHEMBL1201861
Homo sapiens KU812 cell line IC50 96.49 nM 10.6019/CHEMBL1201861
Homo sapiens KURAMOCHI IC50 244.25 nM 10.6019/CHEMBL1201861
Homo sapiens KY821 IC50 246.0 nM 10.6019/CHEMBL1201861
Homo sapiens L-363 IC50 153.11 nM 10.6019/CHEMBL1201861
Homo sapiens L-428 IC50 21163.54 nM 10.6019/CHEMBL1201861
Homo sapiens L-540 IC50 345.91 nM 10.6019/CHEMBL1201861
Homo sapiens LAMA-84 IC50 609.69 nM 10.6019/CHEMBL1201861
Homo sapiens LAN-6 IC50 885.77 nM 10.6019/CHEMBL1201861
Homo sapiens LB1047-RCC IC50 87.19 nM 10.6019/CHEMBL1201861
Homo sapiens LB2241-RCC IC50 33194.86 nM 10.6019/CHEMBL1201861
Homo sapiens LB2518-MEL IC50 397.21 nM 10.6019/CHEMBL1201861
Homo sapiens LB373-MEL-D IC50 531.12 nM 10.6019/CHEMBL1201861
Homo sapiens LB647-SCLC IC50 224.03 nM 10.6019/CHEMBL1201861
Homo sapiens LB771-HNC IC50 222.39 nM 10.6019/CHEMBL1201861
Homo sapiens LB831-BLC IC50 194.08 nM 10.6019/CHEMBL1201861
Homo sapiens LB996-RCC IC50 122.19 nM 10.6019/CHEMBL1201861
Homo sapiens LC-1F IC50 181.05 nM 10.6019/CHEMBL1201861
Homo sapiens LC-2-ad IC50 22.15 nM 10.6019/CHEMBL1201861
Homo sapiens LC4-1 IC50 216.65 nM 10.6019/CHEMBL1201861
Homo sapiens Leukocyte tyrosine kinase receptor Inhibition 35.0 % 10.1038/nchembio.183
Homo sapiens LNCaP-Clone-FGC IC50 18394.93 nM 10.6019/CHEMBL1201861
Homo sapiens LOUCY IC50 157.83 nM 10.6019/CHEMBL1201861
Homo sapiens LOX IMVI IC50 797.13 nM 10.6019/CHEMBL1201861
Homo sapiens LP-1 IC50 34806.77 nM 10.6019/CHEMBL1201861
Homo sapiens LS-1034 IC50 630.03 nM 10.6019/CHEMBL1201861
Homo sapiens LS-123 IC50 337.1 nM 10.6019/CHEMBL1201861
Homo sapiens LS-411N IC50 87.45 nM 10.6019/CHEMBL1201861
Homo sapiens LS-513 IC50 35876.37 nM 10.6019/CHEMBL1201861
Homo sapiens LU-134-A IC50 362.82 nM 10.6019/CHEMBL1201861
Homo sapiens LU-139 IC50 367.29 nM 10.6019/CHEMBL1201861
Homo sapiens LU-165 IC50 619.95 nM 10.6019/CHEMBL1201861
Homo sapiens Lu-65 IC50 13895.01 nM 10.6019/CHEMBL1201861
Homo sapiens LXF-289 cell line IC50 179.4 nM 10.6019/CHEMBL1201861
Homo sapiens Lysine-specific demethylase 4A Potency 35481.3 nM None
Homo sapiens Macrophage colony stimulating factor receptor Inhibition 5.0 % 10.1038/nchembio.183
Homo sapiens Macrophage-stimulating protein receptor Inhibition 10.0 % 10.1038/nchembio.183
Homo sapiens MAP kinase-activated protein kinase 2 Activity 73.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 2 Activity 92.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 2 Inhibition 3.0 % 10.1038/nchembio.183
Homo sapiens MAP kinase-activated protein kinase 3 Activity 91.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 3 Activity 96.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 3 Inhibition 2.0 % 10.1038/nchembio.183
Homo sapiens MAP kinase-activated protein kinase 5 Activity 107.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 5 Inhibition 10.0 % 10.1038/nchembio.183
Homo sapiens MAP kinase ERK1 Activity 59.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK1 Activity 77.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 Activity 64.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 Activity 78.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 Inhibition 61.0 % 10.1038/nchembio.183
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Activity 109.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Activity 120.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Activity 92.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Activity 131.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Inhibition 3.0 % 10.1038/nchembio.183
Homo sapiens MAP kinase p38 beta Activity 105.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 beta Activity 114.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 beta Inhibition 6.0 % 10.1038/nchembio.183
Homo sapiens MAP kinase p38 delta Activity 68.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 delta Activity 86.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 delta Inhibition 36.0 % 10.1038/nchembio.183
Homo sapiens MAP kinase p38 gamma Activity 83.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 gamma Activity 87.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 gamma Inhibition 24.0 % 10.1038/nchembio.183
Homo sapiens MAP kinase signal-integrating kinase 2 Activity 80.0 % 10.1042/bj20070797
Homo sapiens MAP kinase signal-integrating kinase 2 Activity 97.0 % 10.1042/bj20070797
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Inhibition 68.0 % 10.1038/nchembio.183
Homo sapiens Maternal embryonic leucine zipper kinase Activity 63.0 % 10.1042/bj20070797
Homo sapiens Maternal embryonic leucine zipper kinase Activity 96.0 % 10.1042/bj20070797
Homo sapiens MC116 IC50 137.46 nM 10.6019/CHEMBL1201861
Homo sapiens MC-CAR IC50 1801.28 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-134-VI IC50 489.17 nM 10.6019/CHEMBL1201861
Homo sapiens MEG-01 IC50 813.84 nM 10.6019/CHEMBL1201861
Homo sapiens MFH-ino IC50 235.53 nM 10.6019/CHEMBL1201861
Homo sapiens MFM-223 IC50 3304.82 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-CALL-2 IC50 12635.65 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-NB-11 IC50 2333.59 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-PREB-1 IC50 270.51 nM 10.6019/CHEMBL1201861
Homo sapiens MIA PaCa-2 EC50 100.0 nM 10.1016/j.bmcl.2006.04.046
Homo sapiens Misshapen-like kinase 1 Inhibition 98.0 % 10.1038/nchembio.183
Homo sapiens Mitogen-activated protein kinase 15 Activity 28.0 % 10.1042/bj20070797
Homo sapiens Mitogen-activated protein kinase 15 Activity 61.0 % 10.1042/bj20070797
Homo sapiens Mitogen-activated protein kinase kinase kinase 8 Inhibition 50.0 % 10.1038/nchembio.183
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Inhibition 15.0 % 10.1038/nchembio.183
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Inhibition 98.0 % 10.1038/nchembio.183
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Inhibition 43.0 % 10.1038/nchembio.183
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Inhibition 99.0 % 10.1038/nchembio.183
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Inhibition 98.0 % 10.1038/nchembio.183
Homo sapiens ML-2 IC50 192.41 nM 10.6019/CHEMBL1201861
Homo sapiens MLMA IC50 447.01 nM 10.6019/CHEMBL1201861
Homo sapiens MMAC-SF IC50 5203.56 nM 10.6019/CHEMBL1201861
Homo sapiens MN-60 IC50 487.21 nM 10.6019/CHEMBL1201861
Homo sapiens Mo IC50 28646.03 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-16 IC50 83.71 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 IC50 130.92 nM 10.6019/CHEMBL1201861
Homo sapiens MONO-MAC-6 IC50 77.23 nM 10.6019/CHEMBL1201861
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 1000.0 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 1636.0 nM None
Homo sapiens MPP-89 IC50 485.19 nM 10.6019/CHEMBL1201861
Homo sapiens MRK-nu-1 IC50 103.74 nM 10.6019/CHEMBL1201861
Homo sapiens MS-1 IC50 3549.84 nM 10.6019/CHEMBL1201861
Homo sapiens MSTO-211H IC50 105678.98 nM 10.6019/CHEMBL1201861
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Inhibition 6.0 % 10.1038/nchembio.183
Homo sapiens MV4-11 IC50 57.74 nM 10.6019/CHEMBL1201861
Homo sapiens myosin light chain kinase 2 Inhibition 22.0 % 10.1038/nchembio.183
Homo sapiens Myosin light chain kinase, smooth muscle Activity 27.0 % 10.1042/bj20070797
Homo sapiens Myosin light chain kinase, smooth muscle Activity 69.0 % 10.1042/bj20070797
Homo sapiens MZ1-PC IC50 79.54 nM 10.6019/CHEMBL1201861
Homo sapiens MZ2-MEL IC50 2100.26 nM 10.6019/CHEMBL1201861
Homo sapiens MZ7-mel IC50 564.34 nM 10.6019/CHEMBL1201861
Homo sapiens NALM-6 IC50 127.98 nM 10.6019/CHEMBL1201861
Homo sapiens NB1 IC50 117.48 nM 10.6019/CHEMBL1201861
Homo sapiens NB10 IC50 6379.27 nM 10.6019/CHEMBL1201861
Homo sapiens NB13 IC50 332.31 nM 10.6019/CHEMBL1201861
Homo sapiens NB14 IC50 1968.79 nM 10.6019/CHEMBL1201861
Homo sapiens NB17 IC50 112.22 nM 10.6019/CHEMBL1201861
Homo sapiens NB5 IC50 665.12 nM 10.6019/CHEMBL1201861
Homo sapiens NB6 IC50 479.75 nM 10.6019/CHEMBL1201861
Homo sapiens NB69 IC50 226.69 nM 10.6019/CHEMBL1201861
Homo sapiens NB7 IC50 6641.85 nM 10.6019/CHEMBL1201861
Homo sapiens NCCIT IC50 234.23 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1092 IC50 938.39 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1155 IC50 563.94 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H128 IC50 5588.22 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1304 IC50 163.31 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1355 IC50 113.2 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1395 IC50 75870.88 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1417 IC50 583.77 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1436 IC50 477.24 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1522 IC50 464.29 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1581 IC50 605.82 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1648 IC50 183.32 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1650 IC50 1865.21 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1694 IC50 508.67 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1770 IC50 212460.48 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1838 IC50 8262.59 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H187 IC50 464.04 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1882 IC50 428.49 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1963 IC50 392.0 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2081 IC50 1258.79 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H209 IC50 246.36 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2107 IC50 958.37 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2126 IC50 309.18 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2141 IC50 539.67 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2171 IC50 6915.72 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2196 IC50 648.41 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H226 IC50 32214.99 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H23 IC50 1173.71 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H322M IC50 7232.24 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H345 IC50 750.32 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H446 IC50 394.93 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H510A IC50 229.2 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H524 IC50 859.54 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H526 IC50 1658.12 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H64 IC50 3155.58 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H69 IC50 317.92 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H716 IC50 219277.05 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H719 IC50 1936.15 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H720 IC50 154.46 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H747 IC50 82.55 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H748 IC50 508.44 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H82 IC50 164.22 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H889 IC50 9788.49 nM 10.6019/CHEMBL1201861
Homo sapiens NEC8 IC50 3320.59 nM 10.6019/CHEMBL1201861
Homo sapiens Nerve growth factor receptor Trk-A Inhibition 42.0 % 10.1038/nchembio.183
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Inhibition 12.0 % 10.1038/nchembio.183
Homo sapiens NH-12 IC50 133531.18 nM 10.6019/CHEMBL1201861
Homo sapiens NKM-1 IC50 6195.98 nM 10.6019/CHEMBL1201861
Homo sapiens NMC-G1 IC50 880.43 nM 10.6019/CHEMBL1201861
Homo sapiens no-10 IC50 129.02 nM 10.6019/CHEMBL1201861
Homo sapiens no-11 IC50 129.9 nM 10.6019/CHEMBL1201861
Homo sapiens NOMO-1 IC50 560.7 nM 10.6019/CHEMBL1201861
Homo sapiens NOS-1 IC50 93.76 nM 10.6019/CHEMBL1201861
Homo sapiens NT-3 growth factor receptor Inhibition 28.0 % 10.1038/nchembio.183
Homo sapiens NTERA-2-cl-D1 IC50 27.59 nM 10.6019/CHEMBL1201861
Homo sapiens Nuclear factor erythroid 2-related factor 2 Potency 5173.5 nM None
Homo sapiens OCI-AML2 IC50 210.37 nM 10.6019/CHEMBL1201861
Homo sapiens OCUB-M IC50 25.73 nM 10.6019/CHEMBL1201861
Homo sapiens OMC-1 IC50 190.9 nM 10.6019/CHEMBL1201861
Homo sapiens ONS-76 IC50 443.96 nM 10.6019/CHEMBL1201861
Homo sapiens OPM-2 IC50 314.39 nM 10.6019/CHEMBL1201861
Homo sapiens OS-RC-2 IC50 175.45 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-4 IC50 243.27 nM 10.6019/CHEMBL1201861
Homo sapiens P30-OHK IC50 26740.39 nM 10.6019/CHEMBL1201861
Homo sapiens P31-FUJ IC50 17338.73 nM 10.6019/CHEMBL1201861
Homo sapiens PAS domain-containing serine/threonine-protein kinase Inhibition 36.0 % 10.1038/nchembio.183
Homo sapiens PF-382 IC50 637.67 nM 10.6019/CHEMBL1201861
Homo sapiens Phosphorylase kinase gamma subunit 1 Inhibition 76.0 % 10.1038/nchembio.183
Homo sapiens Phosphorylase kinase gamma subunit 2 Inhibition 11.0 % 10.1038/nchembio.183
Homo sapiens Platelet-derived growth factor receptor alpha Inhibition 1.0 % 10.1038/nchembio.183
Homo sapiens Platelet-derived growth factor receptor alpha Inhibition 4.0 % 10.1038/nchembio.183
Homo sapiens Platelet-derived growth factor receptor alpha Inhibition 11.0 % 10.1038/nchembio.183
Homo sapiens Platelet-derived growth factor receptor beta Inhibition 18.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase C alpha Activity 29.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C alpha Activity 73.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C alpha Inhibition 95.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase C beta Inhibition 68.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase C beta Inhibition 97.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase C delta Inhibition 100.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase C epsilon Inhibition 99.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase C eta Inhibition 99.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase C gamma Inhibition 108.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase C iota Inhibition 10.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase C mu Activity 23.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C mu Activity 63.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C mu Inhibition 97.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase C nu Inhibition 94.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase C theta Inhibition 98.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase C zeta Activity 66.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C zeta Activity 82.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C zeta Inhibition 26.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase N1 Inhibition 100.0 % 10.1038/nchembio.183
Homo sapiens Protein kinase N2 Activity 2.0 % 10.1042/bj20070797
Homo sapiens Protein kinase N2 Activity 17.0 % 10.1042/bj20070797
Homo sapiens Protein tyrosine kinase 2 beta Inhibition 2.0 % 10.1038/nchembio.183
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Inhibition 5.0 % 10.1038/nchembio.183
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Inhibition 17.0 % 10.1038/nchembio.183
Homo sapiens PSN1 IC50 47.29 nM 10.6019/CHEMBL1201861
Homo sapiens QIMR-WIL IC50 256.47 nM 10.6019/CHEMBL1201861
Homo sapiens Raji IC50 380.02 nM 10.6019/CHEMBL1201861
Homo sapiens Ramos-2G6-4C10 IC50 170.12 nM 10.6019/CHEMBL1201861
Homo sapiens RCC10RGB IC50 16089.98 nM 10.6019/CHEMBL1201861
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Inhibition -6.0 % 10.1038/nchembio.183
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Inhibition -1.0 % 10.1038/nchembio.183
Homo sapiens REH IC50 12898.45 nM 10.6019/CHEMBL1201861
Homo sapiens RH-1 IC50 106593.34 nM 10.6019/CHEMBL1201861
Homo sapiens Rho-associated protein kinase 1 Inhibition 99.0 % 10.1038/nchembio.183
Homo sapiens Rho-associated protein kinase 2 Activity 8.0 % 10.1042/bj20070797
Homo sapiens Rho-associated protein kinase 2 Activity 48.0 % 10.1042/bj20070797
Homo sapiens Rho-associated protein kinase 2 Inhibition 100.0 % 10.1038/nchembio.183
Homo sapiens Ribosomal protein S6 kinase 1 Activity 32.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase 1 Activity 88.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase 1 Inhibition 99.0 % 10.1038/nchembio.183
Homo sapiens Ribosomal protein S6 kinase alpha 1 Activity 32.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 1 Activity 78.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 1 Inhibition 96.0 % 10.1038/nchembio.183
Homo sapiens Ribosomal protein S6 kinase alpha 2 Inhibition 85.0 % 10.1038/nchembio.183
Homo sapiens Ribosomal protein S6 kinase alpha 3 Activity 27.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 3 Activity 74.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 3 Inhibition 98.0 % 10.1038/nchembio.183
Homo sapiens Ribosomal protein S6 kinase alpha 4 Inhibition 97.0 % 10.1038/nchembio.183
Homo sapiens Ribosomal protein S6 kinase alpha 5 Activity 9.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 5 Activity 19.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 5 Inhibition 102.0 % 10.1038/nchembio.183
Homo sapiens Ribosomal protein S6 kinase alpha 6 Inhibition 87.0 % 10.1038/nchembio.183
Homo sapiens RKO IC50 136.17 nM 10.6019/CHEMBL1201861
Homo sapiens RL IC50 173261.67 nM 10.6019/CHEMBL1201861
Homo sapiens RL95-2 IC50 22.81 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-6666 IC50 151.72 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8226 IC50 670.14 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI 8402 IC50 183.65 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8866 IC50 55033.61 nM 10.6019/CHEMBL1201861
Homo sapiens RS4-11 IC50 168.41 nM 10.6019/CHEMBL1201861
Homo sapiens RXF 393 IC50 656.56 nM 10.6019/CHEMBL1201861
Homo sapiens SBC-1 IC50 160.17 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-15 IC50 4697.95 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-3 IC50 620.41 nM 10.6019/CHEMBL1201861
Homo sapiens SCH IC50 2132.42 nM 10.6019/CHEMBL1201861
Homo sapiens SCLC-21H IC50 1357.18 nM 10.6019/CHEMBL1201861
Homo sapiens Serine/threonine-protein kinase 24 Inhibition 76.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase 25 Inhibition 102.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase AKT Activity 3.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT Activity 5.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT Activity nan None 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase AKT IC50 0.16 nM 10.1016/j.ejmech.2009.04.050
Homo sapiens Serine/threonine-protein kinase AKT IC50 0.16 nM 10.1021/jm0701019
Homo sapiens Serine/threonine-protein kinase AKT IC50 2.5 nM 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase AKT IC50 nan None 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase AKT Inhibition 100.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase AKT Inhibition nan % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase AKT Ki 0.16 nM 10.1016/j.bmcl.2006.04.046
Homo sapiens Serine/threonine-protein kinase AKT Ki 0.16 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Serine/threonine-protein kinase AKT Ki 0.16 nM 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase AKT2 Activity 2.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT2 Activity 17.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT2 Activity nan None 10.1016/j.bmcl.2009.06.078
Homo sapiens Serine/threonine-protein kinase AKT2 IC50 30.0 nM 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase AKT2 Inhibition 94.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase AKT3 IC50 51.0 nM 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase AKT3 Inhibition 99.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase Aurora-A Inhibition 9.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase Aurora-A Inhibition 16.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase Aurora-B Activity 80.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-B Activity 81.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-B Inhibition 17.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase Aurora-C Activity 92.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-C Activity 100.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase B-raf Inhibition 72.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase Chk1 Activity 99.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk1 Activity 100.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk1 Inhibition 4.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase Chk2 Activity 94.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk2 Activity 95.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase c-TAK1 Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase c-TAK1 Activity 100.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase D2 Inhibition 98.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase DCLK2 Inhibition 11.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase EEF2K Activity 93.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase EEF2K Activity 94.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase MARK1 Inhibition 65.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase MRCK-A Inhibition 93.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase MRCK beta Inhibition 94.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase MST1 Inhibition 90.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase MST2 Activity 29.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase MST2 Activity 76.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase MST2 Inhibition 93.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase MST4 Inhibition 88.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase Nek1 Inhibition 44.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase NEK2 Activity 95.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK2 Activity 101.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK2 Inhibition 2.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase Nek4 Inhibition 41.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase NEK6 Activity 95.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK6 Inhibition 3.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase NEK7 Activity 84.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK7 Activity 86.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK7 Inhibition 1.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase NEK9 Inhibition 15.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase PAK 2 Inhibition 55.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase PAK 3 Inhibition 45.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase PAK 4 Activity 90.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK 4 Activity 99.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK 4 Inhibition 26.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase PAK6 Activity 87.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK6 Inhibition 32.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase PAK7 Activity 96.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK7 Activity 104.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK7 Inhibition 25.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 15.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 57.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 Inhibition 100.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase PIM2 Activity 15.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM2 Activity 59.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM2 Inhibition 95.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase PIM3 Activity 13.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM3 Activity 54.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 Activity 80.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 Activity 89.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 Inhibition 1.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase PLK2 Inhibition 6.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase PLK3 Inhibition 7.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase PRKX Inhibition 99.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase RAF Inhibition 81.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase Sgk1 Activity 53.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Sgk1 Activity 78.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Sgk1 Inhibition 85.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase Sgk2 Inhibition 89.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase Sgk3 Inhibition 78.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase SRPK1 Activity 91.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase SRPK1 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase SRPK1 Inhibition 27.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase SRPK2 Inhibition 39.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase SRPK3 Inhibition 3.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase TAO2 Inhibition 35.0 % 10.1038/nchembio.183
Homo sapiens Serine/threonine-protein kinase TBK1 Inhibition 39.0 % 10.1038/nchembio.183
Homo sapiens SF-126 IC50 310.74 nM 10.6019/CHEMBL1201861
Homo sapiens SF-268 IC50 2856.94 nM 10.6019/CHEMBL1201861
Homo sapiens SF-539 IC50 3793.07 nM 10.6019/CHEMBL1201861
Homo sapiens SH-4 IC50 184.99 nM 10.6019/CHEMBL1201861
Homo sapiens SHP77 IC50 10563.05 nM 10.6019/CHEMBL1201861
Homo sapiens SIG-M5 IC50 130.47 nM 10.6019/CHEMBL1201861
Homo sapiens SIMA IC50 246153.42 nM 10.6019/CHEMBL1201861
Homo sapiens SJSA-1 IC50 376.5 nM 10.6019/CHEMBL1201861
Homo sapiens SK-LMS-1 IC50 276.37 nM 10.6019/CHEMBL1201861
Homo sapiens SKM-1 IC50 16973.77 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-1 IC50 41406.34 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-2 IC50 832.58 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MM-2 IC50 622.9 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-DZ IC50 6418.84 nM 10.6019/CHEMBL1201861
Homo sapiens SK-NEP-1 IC50 518.67 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-FI IC50 844.76 nM 10.6019/CHEMBL1201861
Homo sapiens SK-PN-DW IC50 221.52 nM 10.6019/CHEMBL1201861
Homo sapiens SK-UT-1 IC50 81.38 nM 10.6019/CHEMBL1201861
Homo sapiens SNB-75 IC50 115.72 nM 10.6019/CHEMBL1201861
Homo sapiens SNU1 IC50 400.14 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-16 IC50 1728.12 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-5 IC50 3842.4 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C1 IC50 2631.62 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-C2B IC50 290.27 nM 10.6019/CHEMBL1201861
Homo sapiens SR IC50 183.83 nM 10.6019/CHEMBL1201861
Homo sapiens ST486 IC50 203.93 nM 10.6019/CHEMBL1201861
Homo sapiens Stem cell growth factor receptor Inhibition 0.0 % 10.1038/nchembio.183
Homo sapiens Stem cell growth factor receptor Inhibition 4.0 % 10.1038/nchembio.183
Homo sapiens SU-DHL-1 IC50 796.93 nM 10.6019/CHEMBL1201861
Homo sapiens SUP-T1 IC50 276180.32 nM 10.6019/CHEMBL1201861
Homo sapiens SW684 IC50 15906.5 nM 10.6019/CHEMBL1201861
Homo sapiens SW872 IC50 255.39 nM 10.6019/CHEMBL1201861
Homo sapiens SW 954 IC50 177.07 nM 10.6019/CHEMBL1201861
Homo sapiens SW 962 IC50 254.68 nM 10.6019/CHEMBL1201861
Homo sapiens SW982 IC50 166.3 nM 10.6019/CHEMBL1201861
Homo sapiens TALL-1 IC50 241.79 nM 10.6019/CHEMBL1201861
Homo sapiens TE-1 IC50 110.54 nM 10.6019/CHEMBL1201861
Homo sapiens TE-10 IC50 89.4 nM 10.6019/CHEMBL1201861
Homo sapiens TE-11 IC50 130.16 nM 10.6019/CHEMBL1201861
Homo sapiens TE-12 IC50 193.83 nM 10.6019/CHEMBL1201861
Homo sapiens TE-15 IC50 59.09 nM 10.6019/CHEMBL1201861
Homo sapiens TE-441-T IC50 797.81 nM 10.6019/CHEMBL1201861
Homo sapiens TE-5 IC50 168.89 nM 10.6019/CHEMBL1201861
Homo sapiens TE-6 IC50 860.22 nM 10.6019/CHEMBL1201861
Homo sapiens TE-8 IC50 137.48 nM 10.6019/CHEMBL1201861
Homo sapiens TE-9 IC50 388.97 nM 10.6019/CHEMBL1201861
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Inhibition 71.0 % 10.1038/nchembio.183
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Inhibition 4.0 % 10.1038/nchembio.183
Homo sapiens TGBC1TKB IC50 120.43 nM 10.6019/CHEMBL1201861
Homo sapiens TGBC24TKB IC50 810.31 nM 10.6019/CHEMBL1201861
Homo sapiens TGW IC50 569.42 nM 10.6019/CHEMBL1201861
Homo sapiens THP-1 IC50 43012.34 nM 10.6019/CHEMBL1201861
Homo sapiens TK-10 IC50 226.08 nM 10.6019/CHEMBL1201861
Homo sapiens TUR IC50 111115.92 nM 10.6019/CHEMBL1201861
Homo sapiens Tyrosine-protein kinase ABL Inhibition 1.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase ABL Inhibition 4.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase ABL Inhibition 5.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase ABL Inhibition 9.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase ABL2 Inhibition 6.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase BLK Inhibition 9.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase BMX Inhibition -2.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase BRK Inhibition 0.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase BTK Inhibition 4.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase CSK Activity 93.0 % 10.1042/bj20070797
Homo sapiens Tyrosine-protein kinase CSK Activity 99.0 % 10.1042/bj20070797
Homo sapiens Tyrosine-protein kinase CSK Inhibition -1.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase CTK Inhibition -10.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase FER Inhibition 14.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase FES Inhibition 40.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase FGR Inhibition 36.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase FRK Inhibition 6.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase FYN Inhibition 28.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase HCK Inhibition 8.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase ITK/TSK Inhibition 2.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase JAK2 Inhibition -1.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase JAK2 Inhibition 3.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase JAK2 Inhibition 9.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase JAK3 Inhibition 1.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase LCK Inhibition 14.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase Lyn Inhibition 7.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase Lyn Inhibition 8.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase receptor FLT3 Inhibition 89.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase receptor FLT3 Inhibition 98.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase receptor RET Inhibition 29.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase receptor RET Inhibition 30.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase receptor RET Inhibition 48.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Inhibition 14.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase SRC Inhibition 5.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase SRC Inhibition 11.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase Srms Inhibition -1.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase SYK Inhibition 0.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase TIE-2 Inhibition -1.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase YES Inhibition 20.0 % 10.1038/nchembio.183
Homo sapiens Tyrosine-protein kinase ZAP-70 Inhibition 11.0 % 10.1038/nchembio.183
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 580.5 nM None
Homo sapiens U-266 IC50 1821.36 nM 10.6019/CHEMBL1201861
Homo sapiens U-698-M IC50 13298.99 nM 10.6019/CHEMBL1201861
Homo sapiens U-87 MG IC50 19803.88 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-257 IC50 5999.92 nM 10.6019/CHEMBL1201861
Homo sapiens VA-ES-BJ IC50 129.3 nM 10.6019/CHEMBL1201861
Homo sapiens Vascular endothelial growth factor receptor 1 Inhibition -2.0 % 10.1038/nchembio.183
Homo sapiens Vascular endothelial growth factor receptor 2 Inhibition 16.0 % 10.1038/nchembio.183
Homo sapiens Vascular endothelial growth factor receptor 3 Inhibition 1.0 % 10.1038/nchembio.183
Homo sapiens Vitamin D receptor Potency 2511.9 nM None
Homo sapiens WSU-NHL IC50 188382.41 nM 10.6019/CHEMBL1201861
Homo sapiens YT IC50 274977.97 nM 10.6019/CHEMBL1201861
Mus musculus Mus musculus AUC 0.0 ng.hr.mL-1 10.1021/jm0701019
Mus musculus Mus musculus F 0.0 % 10.1016/j.bmcl.2006.04.046
Mus musculus Mus musculus F 0.0 % 10.1021/jm0701019
Mus musculus Mus musculus T1/2 0.6 hr 10.1021/jm0701019
Mus musculus Tyrosine-protein kinase LCK Activity 97.0 % 10.1042/bj20070797
Rattus norvegicus RAC-alpha serine/threonine-protein kinase Activity nan None 10.1038/nchembio.183
None ADMET Activity 2.4 % 10.1021/jm0701019
None BC1 cell line IC50 700.83 nM 10.6019/CHEMBL1201861
None Unchecked AC50 1770.0 nM None
None Unchecked AC50 2850.0 nM None
None Unchecked AC50 7400.0 nM None
None Unchecked Activity 54.0 % 10.1042/bj20070797
None Unchecked Activity 67.0 % 10.1042/bj20070797
None Unchecked Activity 84.0 % 10.1042/bj20070797
None Unchecked Activity 86.0 % 10.1042/bj20070797
None Unchecked IC50 nan None 10.1038/nchembio.183
None Unchecked Inhibition 45.0 % 10.1038/nchembio.183
None Unchecked Potency 316.2 nM None
None Unchecked Potency 794.3 nM None
None Unchecked Potency 891.3 nM None
None Unchecked Potency 1258.9 nM None
None Unchecked Potency 1299.5 nM None
None Unchecked Potency 3548.1 nM None
None Unchecked Potency 7307.8 nM None
None Unchecked Potency 8199.5 nM None
None Unchecked Potency 10322.5 nM None
None Unchecked Selectivity ratio 40.0 None 10.1021/jm0701019
None Unchecked Selectivity ratio 68.0 None 10.1021/jm0701019
None Unchecked Selectivity ratio 150.0 None 10.1021/jm0701019
None Unchecked Selectivity ratio 200.0 None 10.1021/jm0701019
None Unchecked Selectivity ratio 260.0 None 10.1021/jm0701019
None Unchecked Selectivity ratio 2100.0 None 10.1021/jm0701019
None Unchecked Selectivity ratio 7300.0 None 10.1021/jm0701019
None Unchecked Selectivity ratio 15000.0 None 10.1021/jm0701019
None Unchecked Selectivity ratio 16000.0 None 10.1021/jm0701019
None Unchecked Selectivity ratio 19000.0 None 10.1021/jm0701019
None Unchecked Selectivity ratio 21000.0 None 10.1021/jm0701019
None Unchecked Selectivity ratio 22000.0 None 10.1021/jm0701019

Metabolism Information