Indothiazinone
AlkaPlorer ID: AK075156
Synonym: 'Indothiazinone'
IUPAC Name: 1H-indol-3-yl(1,3-thiazol-2-yl)methanone
Structure
SMILES: O=C(C1=NC=CS1)C1=CNC2=CC=CC=C12
InChI: InChI=1S/C12H8N2OS/c15-11(12-13-5-6-16-12)9-7-14-10-4-2-1-3-8(9)10/h1-7,14H
InChIKey: DFYPIVYFSGGXGT-UHFFFAOYSA-N
Reference
Indothiazinone, an Indolyl Thiazolyl Ketone from a Novel Myxobacterium Belonging to the Sorangiineae
PubChem CID: 69252541
LOTUS: LTS0131463
COCONUT: CNP0353135
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Actinoplanes capillaceus | Actinoplanes | Micromonosporaceae | Micromonosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 228.276
TPSA？: 45.75
MolLogP？: 2.8554000000000004
Number of H-Donors: 1
Number of H-Acceptors: 3
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Amorphotheca resinae | Amorphotheca resinae | Inhibition | nan | % | 10.1021/np500144t |
| Aspergillus clavatus | Aspergillus clavatus | MIC | 33.3 | ug.mL-1 | 10.1021/np500144t |
| Candida albicans | Candida albicans | Inhibition | nan | % | 10.1021/np500144t |
| Chromobacterium violaceum | Chromobacterium violaceum | Inhibition | nan | % | 10.1021/np500144t |
| Debaryomyces hansenii | Debaryomyces hansenii | Inhibition | nan | % | 10.1021/np500144t |
| Eremothecium coryli | Eremothecium coryli | MIC | 33.3 | ug.mL-1 | 10.1021/np500144t |
| Escherichia coli | Escherichia coli | Inhibition | nan | % | 10.1021/np500144t |
| Homo sapiens | Aryl hydrocarbon receptor | Activity | nan | None | 10.1021/acs.jmedchem.2c00208 |
| Homo sapiens | Aryl hydrocarbon receptor | Efficacy | 144.7 | % | 10.1021/acs.jmedchem.2c00208 |
| Micrococcus luteus | Micrococcus luteus | Inhibition | nan | % | 10.1021/np500144t |
| Mucor hiemalis | Mucor hiemalis | MIC | 33.3 | ug.mL-1 | 10.1021/np500144t |
| Mus musculus | L929 | LC50 | 10.0 | ug.mL-1 | 10.1021/np500144t |
| Mycolicibacterium diernhoferi | Mycolicibacterium diernhoferi | Inhibition | nan | % | 10.1021/np500144t |
| Nocardia sp. | Nocardia sp. | Inhibition | nan | % | 10.1021/np500144t |
| Paenibacillus polymyxa | Paenibacillus polymyxa | Inhibition | nan | % | 10.1021/np500144t |
| Pichia membranifaciens | Pichia membranifaciens | Inhibition | nan | % | 10.1021/np500144t |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | Inhibition | nan | % | 10.1021/np500144t |
| Rhodotorula glutinis | Rhodotorula glutinis | MIC | 67.0 | ug.mL-1 | 10.1021/np500144t |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | Inhibition | nan | % | 10.1021/np500144t |
| Schizosaccharomyces pombe | Schizosaccharomyces pombe | Inhibition | nan | % | 10.1021/np500144t |
| Staphylococcus aureus | Staphylococcus aureus | Inhibition | nan | % | 10.1021/np500144t |
| Wickerhamomyces anomalus | Wickerhamomyces anomalus | Inhibition | nan | % | 10.1021/np500144t |
| None | NON-PROTEIN TARGET | Inhibition | nan | % | 10.1021/np500144t |
| None | NON-PROTEIN TARGET | MIC | 67.0 | ug.mL-1 | 10.1021/np500144t |