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name Structure Reference Source Properties Activities Metabolism

clorgyline

AlkaPlorer ID: AK075940

Synonym: None

IUPAC Name: 3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine

Structure

SMILES: C#CCN(C)CCCOC1=CC=C(Cl)C=C1Cl

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InChI: InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3

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InChIKey: BTFHLQRNAMSNLC-UHFFFAOYSA-N

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Reference

PubChem CID: 4380

CAS: 17780-72-2

SuperNatural Ⅲ: SN0034782

NPASS: NPC347588

COCONUT: CNP0111714

Properties Information

Molecule Weight: 272.175

TPSA？: 12.47

MolLogP？: 3.327300000000002

Number of H-Donors: 0

Number of H-Acceptors: 2

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus anthracis Anthrax lethal factor Potency 2511.9 nM None
Bos taurus Monoamine oxidase SI 1074.0 None 10.1021/jm0256124
Bos taurus Monoamine oxidase A IC50 2.9 nM 10.1016/j.bmc.2015.04.021
Bos taurus Monoamine oxidase A IC50 3.1 nM 10.1016/j.ejmech.2015.02.020
Bos taurus Monoamine oxidase A IC50 3.1 nM 10.1016/j.ejmech.2015.02.039
Bos taurus Monoamine oxidase A IC50 3.65 nM 10.1016/j.bmcl.2015.09.048
Bos taurus Monoamine oxidase A Ki 54.0 nM 10.1016/j.bmc.2008.09.072
Bos taurus Monoamine oxidase A Ki 54.0 nM 10.1021/jm0256124
Bos taurus Monoamine oxidase A Ki 54.0 nM 10.1021/jm060882y
Bos taurus Monoamine oxidase A Ki 54.0 nM 10.1021/jm301014y
Bos taurus Monoamine oxidase B IC50 98000.0 nM 10.1016/j.bmc.2015.04.021
Bos taurus Monoamine oxidase B IC50 98000.0 nM 10.1016/j.bmcl.2014.11.007
Bos taurus Monoamine oxidase B IC50 940000.0 nM 10.1016/j.ejmech.2015.02.020
Bos taurus Monoamine oxidase B IC50 9400000.0 nM 10.1016/j.ejmech.2015.02.039
Bos taurus Monoamine oxidase B Ki 58000.0 nM 10.1016/j.bmc.2008.09.072
Bos taurus Monoamine oxidase B Ki 58000.0 nM 10.1021/jm0256124
Bos taurus Monoamine oxidase B Ki 58000.0 nM 10.1021/jm060882y
Bos taurus Monoamine oxidase B Ki 58000.0 nM 10.1021/jm301014y
Electrophorus electricus Acetylcholinesterase IC50 500000.0 nM 10.1016/j.ejmech.2014.04.078
Electrophorus electricus Acetylcholinesterase IC50 nan None 10.1016/j.bmcl.2017.09.057
Electrophorus electricus Acetylcholinesterase IC50 nan None 10.1016/j.ejmech.2013.01.039
Electrophorus electricus Acetylcholinesterase IC50 nan None 10.1016/j.ejmech.2016.09.041
Electrophorus electricus Acetylcholinesterase IC50 nan None 10.1016/j.ejmech.2019.05.039
Electrophorus electricus Acetylcholinesterase IC50 nan None 10.1016/j.ejmech.2020.112743
Electrophorus electricus Acetylcholinesterase IC50 nan None 10.1021/acs.jmedchem.5b00958
Electrophorus electricus Acetylcholinesterase IC50 nan None 10.1021/jm400567s
Electrophorus electricus Acetylcholinesterase Inhibition nan % 10.1021/acs.jnatprod.9b00469
Equus caballus Cholinesterase IC50 500000.0 nM 10.1016/j.ejmech.2014.04.078
Equus caballus Cholinesterase IC50 nan None 10.1016/j.bmcl.2017.09.057
Equus caballus Cholinesterase IC50 nan None 10.1016/j.ejmech.2013.01.039
Equus caballus Cholinesterase IC50 nan None 10.1016/j.ejmech.2016.09.041
Equus caballus Cholinesterase IC50 nan None 10.1016/j.ejmech.2020.112743
Equus caballus Cholinesterase IC50 nan None 10.1021/acs.jmedchem.5b00958
Equus caballus Cholinesterase IC50 nan None 10.1021/jm400567s
Equus caballus Cholinesterase Inhibition nan % 10.1021/acs.jnatprod.9b00469
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 14125.4 nM None
Homo sapiens Acetylcholinesterase IC50 500000.0 nM 10.1016/j.ejmech.2015.10.001
Homo sapiens Acetylcholinesterase IC50 nan None 10.1021/acs.jmedchem.5b00599
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 7079.5 nM None
Homo sapiens Amyloid-beta A4 protein Activity nan None 10.1016/j.ejmech.2020.112265
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.bmc.2018.01.030
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.bmc.2020.115400
Homo sapiens Amyloid-beta A4 protein Inhibition nan % 10.1016/j.ejmech.2020.112265
Homo sapiens ATPase family AAA domain-containing protein 5 Potency 20587.8 nM None
Homo sapiens Butyrylcholinesterase IC50 500000.0 nM 10.1016/j.ejmech.2015.10.001
Homo sapiens Butyrylcholinesterase IC50 nan None 10.1016/j.bmc.2016.11.032
Homo sapiens Butyrylcholinesterase IC50 nan None 10.1021/acs.jmedchem.5b00599
Homo sapiens Caspase-3 IC50 100000.0 nM 10.1039/C6MD00228E
Homo sapiens Cerebroside-sulfatase Potency 8492.1 nM None
Homo sapiens Cytochrome P450 1A2 AC50 158.49 nM None
Homo sapiens Cytochrome P450 1A2 AC50 630.96 nM None
Homo sapiens Cytochrome P450 2C19 AC50 2511.89 nM None
Homo sapiens Cytochrome P450 2C19 AC50 5011.87 nM None
Homo sapiens Cytochrome P450 2C19 Potency 2511.9 nM None
Homo sapiens Cytochrome P450 2C19 Potency 5011.9 nM None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 AC50 398.11 nM None
Homo sapiens Cytochrome P450 2D6 AC50 1995.26 nM None
Homo sapiens Cytochrome P450 2D6 Potency 398.1 nM None
Homo sapiens Cytochrome P450 2D6 Potency 1995.3 nM None
Homo sapiens Cytochrome P450 3A4 AC50 25118.86 nM None
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 Potency 25118.9 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 31.6 nM None
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2A IC50 nan None 10.1021/acs.jmedchem.5b00958
Homo sapiens Glutamate NMDA receptor; GRIN1/GRIN2B IC50 nan None 10.1021/acs.jmedchem.5b00958
Homo sapiens HEK293 Potency 12990.0 nM None
Homo sapiens Histamine H3 receptor Ki nan None 10.1016/j.ejmech.2020.112743
Homo sapiens Histone-lysine N-methyltransferase EZH2 IC50 nan None 10.1016/j.ejmech.2022.114410
Homo sapiens Histone-lysine N-methyltransferase EZH2 Inhibition nan % 10.1016/j.ejmech.2022.114410
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-79 specific IC50 nan None 10.1016/j.ejmech.2022.114410
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-79 specific Inhibition nan % 10.1016/j.ejmech.2022.114410
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 23778.1 nM None
Homo sapiens Hypoxia-inducible factor 1 alpha Potency 25118.9 nM None
Homo sapiens Lysine-specific histone demethylase 1 IC50 nan None 10.1016/j.bmcl.2021.127993
Homo sapiens Lysine-specific histone demethylase 1 IC50 nan None 10.1016/j.ejmech.2014.08.068
Homo sapiens Lysine-specific histone demethylase 1 Inhibition nan % 10.1016/j.ejmech.2014.08.068
Homo sapiens MAP kinase ERK2 Potency 6.3 nM None
Homo sapiens Monoamine oxidase A Activity 17.3 % 10.1016/j.bmcl.2018.01.049
Homo sapiens Monoamine oxidase A Activity 17.3 % 10.1016/j.bmcl.2018.06.023
Homo sapiens Monoamine oxidase A Activity 18.3 % 10.1016/j.bmcl.2018.01.049
Homo sapiens Monoamine oxidase A Activity 18.3 % 10.1016/j.bmcl.2018.06.023
Homo sapiens Monoamine oxidase A Activity 19.8 % 10.1039/C8MD00399H
Homo sapiens Monoamine oxidase A Activity 20.4 % 10.1016/j.bmcl.2019.01.016
Homo sapiens Monoamine oxidase A Activity 21.4 % 10.1039/C8MD00399H
Homo sapiens Monoamine oxidase A Activity 23.3 % 10.1016/j.bmcl.2019.01.016
Homo sapiens Monoamine oxidase A Activity 24.9 % 10.1016/j.bmcl.2017.01.085
Homo sapiens Monoamine oxidase A Activity 88.31 % 10.1039/d0md00150c
Homo sapiens Monoamine oxidase A Activity 93.42 % 10.1039/d0md00150c
Homo sapiens Monoamine oxidase A IC50 0.0049 nM 10.1016/j.bmc.2010.07.034
Homo sapiens Monoamine oxidase A IC50 0.61 nM 10.1021/acs.jmedchem.1c00966
Homo sapiens Monoamine oxidase A IC50 1.0 nM 10.1016/j.ejmech.2016.09.041
Homo sapiens Monoamine oxidase A IC50 1.0 nM 10.1021/acs.jmedchem.1c01726
Homo sapiens Monoamine oxidase A IC50 1.0 nM 10.1039/C6MD00228E
Homo sapiens Monoamine oxidase A IC50 1.06 nM 10.1039/C7MD00569E
Homo sapiens Monoamine oxidase A IC50 1.1 nM 10.1016/j.bmcl.2021.127993
Homo sapiens Monoamine oxidase A IC50 1.2 nM 10.1021/acs.jmedchem.0c01192
Homo sapiens Monoamine oxidase A IC50 1.6 nM 10.1021/acs.jmedchem.0c01663
Homo sapiens Monoamine oxidase A IC50 2.0 nM 10.1021/acs.jmedchem.7b01588
Homo sapiens Monoamine oxidase A IC50 2.5 nM 10.1016/j.bmc.2021.116074
Homo sapiens Monoamine oxidase A IC50 2.5 nM 10.1021/acs.jmedchem.6b00562
Homo sapiens Monoamine oxidase A IC50 2.6 nM 10.1016/j.bmcl.2012.10.070
Homo sapiens Monoamine oxidase A IC50 2.6 nM 10.1016/j.bmcl.2022.128746
Homo sapiens Monoamine oxidase A IC50 2.7 nM 10.1016/j.bmc.2016.04.012
Homo sapiens Monoamine oxidase A IC50 2.7 nM 10.1016/j.bmc.2016.11.048
Homo sapiens Monoamine oxidase A IC50 2.7 nM 10.1016/j.bmc.2016.12.013
Homo sapiens Monoamine oxidase A IC50 2.7 nM 10.1016/j.bmc.2017.02.027
Homo sapiens Monoamine oxidase A IC50 2.7 nM 10.1016/j.bmc.2018.01.030
Homo sapiens Monoamine oxidase A IC50 2.7 nM 10.1016/j.bmc.2018.02.037
Homo sapiens Monoamine oxidase A IC50 2.7 nM 10.1016/j.ejmech.2016.12.009
Homo sapiens Monoamine oxidase A IC50 2.7 nM 10.1016/j.ejmech.2021.113310
Homo sapiens Monoamine oxidase A IC50 2.74 nM 10.1016/j.ejmech.2019.111770
Homo sapiens Monoamine oxidase A IC50 2.9 nM 10.1016/j.bmc.2020.115374
Homo sapiens Monoamine oxidase A IC50 3.0 nM 10.1021/acs.jmedchem.5b00958
Homo sapiens Monoamine oxidase A IC50 3.1 nM 10.1016/j.bmc.2018.10.037
Homo sapiens Monoamine oxidase A IC50 3.1 nM 10.1016/j.ejmech.2010.07.008
Homo sapiens Monoamine oxidase A IC50 3.1 nM 10.1016/j.ejmech.2021.114085
Homo sapiens Monoamine oxidase A IC50 3.21 nM 10.1021/acs.jmedchem.1c00510
Homo sapiens Monoamine oxidase A IC50 3.4 nM 10.1016/j.bmc.2016.11.032
Homo sapiens Monoamine oxidase A IC50 3.4 nM 10.1016/j.bmc.2017.03.070
Homo sapiens Monoamine oxidase A IC50 3.4 nM 10.1016/j.bmcl.2017.09.057
Homo sapiens Monoamine oxidase A IC50 3.4 nM 10.1016/j.ejmech.2020.112911
Homo sapiens Monoamine oxidase A IC50 3.4 nM 10.1021/acs.jmedchem.9b01886
Homo sapiens Monoamine oxidase A IC50 3.6 nM 10.1016/j.ejmech.2017.09.038
Homo sapiens Monoamine oxidase A IC50 3.8 nM 10.1016/j.ejmech.2018.10.016
Homo sapiens Monoamine oxidase A IC50 4.0 nM 10.1016/j.bmc.2009.12.029
Homo sapiens Monoamine oxidase A IC50 4.0 nM 10.1016/j.ejmech.2011.09.045
Homo sapiens Monoamine oxidase A IC50 4.0 nM 10.1021/acs.jnatprod.9b00469
Homo sapiens Monoamine oxidase A IC50 4.0 nM 10.1021/jm801496u
Homo sapiens Monoamine oxidase A IC50 4.1 nM 10.1016/j.bmc.2013.09.050
Homo sapiens Monoamine oxidase A IC50 4.1 nM 10.1016/j.bmc.2015.04.009
Homo sapiens Monoamine oxidase A IC50 4.1 nM 10.1016/j.ejmech.2013.01.039
Homo sapiens Monoamine oxidase A IC50 4.1 nM 10.1021/jm300978h
Homo sapiens Monoamine oxidase A IC50 4.1 nM 10.1021/jm400567s
Homo sapiens Monoamine oxidase A IC50 4.39 nM 10.1016/j.ejmech.2019.05.039
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1016/j.bmc.2010.06.007
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1016/j.bmc.2014.03.042
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1016/j.ejmech.2009.11.003
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1016/j.ejmech.2010.07.009
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1016/j.ejmech.2012.10.032
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1016/j.ejmech.2012.11.006
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1016/j.ejmech.2016.03.081
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1016/j.ejmech.2017.10.050
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1021/acs.jmedchem.6b00527
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1021/acs.jmedchem.7b00918
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1021/jm100120s
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1021/jm1013709
Homo sapiens Monoamine oxidase A IC50 4.46 nM 10.1021/jm800656v
Homo sapiens Monoamine oxidase A IC50 4.467 nM 10.1016/j.bmcl.2010.09.061
Homo sapiens Monoamine oxidase A IC50 4.5 nM 10.1016/j.bmcl.2013.07.035
Homo sapiens Monoamine oxidase A IC50 4.5 nM 10.1016/j.ejmech.2018.07.056
Homo sapiens Monoamine oxidase A IC50 4.5 nM 10.1021/jm801590u
Homo sapiens Monoamine oxidase A IC50 4.5 nM 10.1039/C6MD00570E
Homo sapiens Monoamine oxidase A IC50 4.58 nM 10.1016/j.ejmech.2020.112475
Homo sapiens Monoamine oxidase A IC50 4.6 nM 10.1016/j.ejmech.2011.12.027
Homo sapiens Monoamine oxidase A IC50 4.6 nM 10.1016/j.ejmech.2015.12.026
Homo sapiens Monoamine oxidase A IC50 4.7 nM 10.1021/jm501501a
Homo sapiens Monoamine oxidase A IC50 4.9 nM 10.1016/j.bmc.2021.116255
Homo sapiens Monoamine oxidase A IC50 4.9 nM 10.1016/j.bmcl.2016.08.044
Homo sapiens Monoamine oxidase A IC50 4.9 nM 10.1016/j.bmcl.2019.01.016
Homo sapiens Monoamine oxidase A IC50 4.9 nM 10.1021/acs.jmedchem.5b00599
Homo sapiens Monoamine oxidase A IC50 5.0 nM 10.1016/j.bmc.2010.05.070
Homo sapiens Monoamine oxidase A IC50 5.2 nM 10.1016/j.bmcl.2010.03.081
Homo sapiens Monoamine oxidase A IC50 5.2 nM 10.1039/C7MD00311K
Homo sapiens Monoamine oxidase A IC50 5.4 nM 10.1016/j.ejmech.2017.03.009
Homo sapiens Monoamine oxidase A IC50 6.2 nM 10.1016/j.bmcl.2018.01.049
Homo sapiens Monoamine oxidase A IC50 6.7 nM 10.1016/j.bmcl.2012.06.058
Homo sapiens Monoamine oxidase A IC50 7.1 nM 10.1039/C8MD00399H
Homo sapiens Monoamine oxidase A IC50 7.31 nM 10.1039/C5MD00357A
Homo sapiens Monoamine oxidase A IC50 7.9 nM 10.1016/j.bmcl.2017.01.050
Homo sapiens Monoamine oxidase A IC50 7.91 nM 10.1016/j.bmc.2020.115400
Homo sapiens Monoamine oxidase A IC50 8.0 nM 10.1016/j.bmc.2015.08.012
Homo sapiens Monoamine oxidase A IC50 8.0 nM 10.1016/j.bmc.2017.11.036
Homo sapiens Monoamine oxidase A IC50 10.0 nM 10.1016/j.bmcl.2018.06.023
Homo sapiens Monoamine oxidase A IC50 10.0 nM 10.1016/j.ejmech.2018.11.051
Homo sapiens Monoamine oxidase A IC50 12.4 nM 10.1021/jm301686s
Homo sapiens Monoamine oxidase A IC50 12.85 nM 10.1016/j.ejmech.2017.08.025
Homo sapiens Monoamine oxidase A IC50 16.0 nM 10.1016/j.ejmech.2015.10.001
Homo sapiens Monoamine oxidase A IC50 20.0 nM 10.1016/j.bmc.2016.06.045
Homo sapiens Monoamine oxidase A IC50 20.0 nM 10.1021/jm701575k
Homo sapiens Monoamine oxidase A IC50 25.0 nM 10.1016/j.bmc.2019.03.060
Homo sapiens Monoamine oxidase A IC50 27.0 nM None
Homo sapiens Monoamine oxidase A IC50 30.2 nM 10.1021/jm200710b
Homo sapiens Monoamine oxidase A IC50 38.0 nM 10.1016/j.bmcl.2019.02.008
Homo sapiens Monoamine oxidase A IC50 40.0 nM 10.1016/j.bmcl.2019.02.030
Homo sapiens Monoamine oxidase A IC50 43.0 nM 10.1016/j.ejmech.2022.114410
Homo sapiens Monoamine oxidase A IC50 48.0 nM 10.1039/d0md00150c
Homo sapiens Monoamine oxidase A IC50 50.0 nM 10.1016/j.ejmech.2020.113112
Homo sapiens Monoamine oxidase A IC50 189.0 nM 10.1016/j.bmc.2016.02.045
Homo sapiens Monoamine oxidase A IC50 189.0 nM 10.1016/j.ejmech.2018.01.029
Homo sapiens Monoamine oxidase A IC50 2720.0 nM 10.1016/j.ejmech.2015.08.055
Homo sapiens Monoamine oxidase A IC50 2760.0 nM 10.1016/j.bmc.2014.12.010
Homo sapiens Monoamine oxidase A IC50 3200.0 nM 10.1016/j.ejmech.2021.113183
Homo sapiens Monoamine oxidase A IC50 4460.0 nM 10.1016/j.ejmech.2011.07.017
Homo sapiens Monoamine oxidase A IC50 4460.0 nM 10.1021/jm800132g
Homo sapiens Monoamine oxidase A IC50 4460.0 nM 10.1039/C0MD00014K
Homo sapiens Monoamine oxidase A IC50 22600.0 nM 10.1016/j.ejmech.2020.112265
Homo sapiens Monoamine oxidase A IC50 nan None 10.1016/j.ejmech.2021.113558
Homo sapiens Monoamine oxidase A IC50 nan None 10.1021/jm801590u
Homo sapiens Monoamine oxidase A Inhibition 1.8 % 10.1016/j.ejmech.2020.112743
Homo sapiens Monoamine oxidase A Inhibition 11.33 % 10.1039/d0md00150c
Homo sapiens Monoamine oxidase A Inhibition 17.0 % 10.1039/d0md00150c
Homo sapiens Monoamine oxidase A Inhibition 21.72 % 10.1039/d0md00150c
Homo sapiens Monoamine oxidase A Inhibition 35.26 % 10.1039/d0md00150c
Homo sapiens Monoamine oxidase A Inhibition 63.94 % 10.1039/d0md00150c
Homo sapiens Monoamine oxidase A Inhibition 79.11 % 10.1039/d0md00150c
Homo sapiens Monoamine oxidase A Inhibition 88.55 % 10.1039/d0md00150c
Homo sapiens Monoamine oxidase A Inhibition 92.0 % 10.1016/j.ejmech.2022.114818
Homo sapiens Monoamine oxidase A Inhibition 92.15 % 10.1039/d0md00150c
Homo sapiens Monoamine oxidase A Inhibition 96.38 % 10.1039/d0md00150c
Homo sapiens Monoamine oxidase A Inhibition 99.8 % 10.1016/j.bmc.2022.116807
Homo sapiens Monoamine oxidase A Inhibition 100.0 % 10.1021/acs.jmedchem.9b01886
Homo sapiens Monoamine oxidase A Inhibition 100.4 % 10.1021/acsmedchemlett.1c00344
Homo sapiens Monoamine oxidase A Inhibition nan % 10.1016/j.bmc.2011.10.038
Homo sapiens Monoamine oxidase A Inhibition nan % 10.1016/j.ejmech.2011.12.027
Homo sapiens Monoamine oxidase A Inhibition nan % 10.1016/j.ejmech.2015.10.001
Homo sapiens Monoamine oxidase A Inhibition nan % 10.1016/j.ejmech.2022.114410
Homo sapiens Monoamine oxidase A Inhibition nan % 10.1039/C7MD00569E
Homo sapiens Monoamine oxidase A Ki 0.3 nM 10.1039/C6MD00228E
Homo sapiens Monoamine oxidase A Ki 12.0 nM 10.1016/j.ejmech.2013.07.005
Homo sapiens Monoamine oxidase A Ki 40.0 nM 10.1021/acs.jmedchem.9b01886
Homo sapiens Monoamine oxidase A Ki 220.0 nM 10.1021/acs.jmedchem.9b01886
Homo sapiens Monoamine oxidase A Ki nan None 10.1016/j.bmcl.2019.01.016
Homo sapiens Monoamine oxidase A Kinact 0.12 /min 10.1021/acs.jmedchem.9b01886
Homo sapiens Monoamine oxidase A Ratio 0.55 /min/microM 10.1021/acs.jmedchem.9b01886
Homo sapiens Monoamine oxidase A TDI nan None 10.1039/C6MD00228E
Homo sapiens Monoamine oxidase B IC50 2.2 nM 10.1016/j.ejmech.2020.112265
Homo sapiens Monoamine oxidase B IC50 21.0 nM 10.1016/j.bmcl.2021.128051
Homo sapiens Monoamine oxidase B IC50 1000.0 nM 10.1016/j.bmc.2015.08.012
Homo sapiens Monoamine oxidase B IC50 1000.0 nM 10.1016/j.bmc.2017.11.036
Homo sapiens Monoamine oxidase B IC50 1690.0 nM 10.1039/C8MD00399H
Homo sapiens Monoamine oxidase B IC50 2000.0 nM 10.1016/j.bmcl.2016.08.044
Homo sapiens Monoamine oxidase B IC50 2000.0 nM 10.1016/j.bmcl.2018.01.049
Homo sapiens Monoamine oxidase B IC50 2000.0 nM 10.1016/j.bmcl.2019.01.016
Homo sapiens Monoamine oxidase B IC50 2210.0 nM 10.1016/j.ejmech.2019.111770
Homo sapiens Monoamine oxidase B IC50 2212.0 nM 10.1021/acs.jmedchem.1c00510
Homo sapiens Monoamine oxidase B IC50 2340.0 nM 10.1016/j.bmc.2020.115374
Homo sapiens Monoamine oxidase B IC50 2430.0 nM 10.1016/j.bmc.2017.02.027
Homo sapiens Monoamine oxidase B IC50 2500.0 nM 10.1016/j.ejmech.2018.10.016
Homo sapiens Monoamine oxidase B IC50 2550.0 nM 10.1021/acs.jmedchem.6b00562
Homo sapiens Monoamine oxidase B IC50 4190.0 nM 10.1016/j.bmc.2016.04.012
Homo sapiens Monoamine oxidase B IC50 4190.0 nM 10.1016/j.bmc.2016.11.048
Homo sapiens Monoamine oxidase B IC50 4190.0 nM 10.1016/j.bmc.2016.12.013
Homo sapiens Monoamine oxidase B IC50 4190.0 nM 10.1016/j.bmc.2018.02.037
Homo sapiens Monoamine oxidase B IC50 4190.0 nM 10.1016/j.ejmech.2016.12.009
Homo sapiens Monoamine oxidase B IC50 5020.0 nM 10.1016/j.bmc.2017.03.070
Homo sapiens Monoamine oxidase B IC50 5020.0 nM 10.1016/j.bmcl.2017.09.057
Homo sapiens Monoamine oxidase B IC50 5800.0 nM 10.1016/j.bmc.2021.116255
Homo sapiens Monoamine oxidase B IC50 7647.0 nM 10.1021/acs.jmedchem.7b01588
Homo sapiens Monoamine oxidase B IC50 8850.0 nM 10.1016/j.bmc.2020.115400
Homo sapiens Monoamine oxidase B IC50 8850.0 nM 10.1016/j.bmcl.2017.01.050
Homo sapiens Monoamine oxidase B IC50 8870.0 nM 10.1016/j.ejmech.2022.114242
Homo sapiens Monoamine oxidase B IC50 11000.0 nM 10.1021/acs.jmedchem.5b00599
Homo sapiens Monoamine oxidase B IC50 13568.0 nM 10.1016/j.bmc.2016.11.032
Homo sapiens Monoamine oxidase B IC50 13568.4 nM 10.1021/acs.jmedchem.9b01886
Homo sapiens Monoamine oxidase B IC50 13600.0 nM 10.1016/j.ejmech.2020.112911
Homo sapiens Monoamine oxidase B IC50 14190.0 nM 10.1016/j.bmc.2021.116074
Homo sapiens Monoamine oxidase B IC50 14300.0 nM None
Homo sapiens Monoamine oxidase B IC50 20270.0 nM 10.1016/j.bmcl.2019.02.008
Homo sapiens Monoamine oxidase B IC50 20270.0 nM 10.1016/j.bmcl.2021.128051
Homo sapiens Monoamine oxidase B IC50 20300.0 nM 10.1016/j.bmcl.2019.02.030
Homo sapiens Monoamine oxidase B IC50 20800.0 nM 10.1016/j.bmc.2018.01.030
Homo sapiens Monoamine oxidase B IC50 20800.0 nM 10.1016/j.ejmech.2021.113310
Homo sapiens Monoamine oxidase B IC50 54300.0 nM 10.1021/acs.jmedchem.5b00958
Homo sapiens Monoamine oxidase B IC50 60000.0 nM 10.1016/j.ejmech.2015.08.055
Homo sapiens Monoamine oxidase B IC50 60000.0 nM 10.1016/j.ejmech.2018.01.029
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.bmc.2009.12.029
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.bmc.2010.06.007
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.bmc.2014.03.042
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.bmcl.2013.07.035
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.ejmech.2009.11.003
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.ejmech.2010.07.009
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.ejmech.2011.07.017
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.ejmech.2011.12.027
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.ejmech.2012.10.032
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.ejmech.2012.11.006
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.ejmech.2015.12.026
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.ejmech.2016.03.081
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1016/j.ejmech.2017.10.050
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1021/jm100120s
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1021/jm1013709
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1021/jm800132g
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1021/jm800656v
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1021/jm801496u
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1021/jm801590u
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1039/C0MD00014K
Homo sapiens Monoamine oxidase B IC50 61350.0 nM 10.1039/C6MD00570E
Homo sapiens Monoamine oxidase B IC50 61356.0 nM 10.1016/j.bmc.2010.05.070
Homo sapiens Monoamine oxidase B IC50 61659.5 nM 10.1016/j.bmcl.2010.09.061
Homo sapiens Monoamine oxidase B IC50 62010.0 nM 10.1016/j.ejmech.2020.112475
Homo sapiens Monoamine oxidase B IC50 63400.0 nM 10.1016/j.ejmech.2018.07.056
Homo sapiens Monoamine oxidase B IC50 63410.0 nM 10.1016/j.bmcl.2010.03.081
Homo sapiens Monoamine oxidase B IC50 63410.0 nM 10.1016/j.ejmech.2011.09.045
Homo sapiens Monoamine oxidase B IC50 63410.0 nM 10.1021/acs.jmedchem.6b00527
Homo sapiens Monoamine oxidase B IC50 63410.0 nM 10.1039/C7MD00311K
Homo sapiens Monoamine oxidase B IC50 65500.0 nM 10.1016/j.bmc.2016.06.045
Homo sapiens Monoamine oxidase B IC50 65500.0 nM 10.1016/j.ejmech.2015.10.001
Homo sapiens Monoamine oxidase B IC50 65800.0 nM 10.1021/jm501501a
Homo sapiens Monoamine oxidase B IC50 71500.0 nM 10.1039/C5MD00357A
Homo sapiens Monoamine oxidase B IC50 2212000.0 nM 10.1016/j.ejmech.2021.113183
Homo sapiens Monoamine oxidase B IC50 9400000.0 nM 10.1016/j.ejmech.2010.07.008
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.bmc.2015.04.009
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.bmc.2019.03.060
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.bmcl.2022.128746
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2013.01.039
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2016.09.041
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2017.08.025
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2019.05.039
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2020.112743
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2020.113112
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2021.113558
Homo sapiens Monoamine oxidase B IC50 nan None 10.1016/j.ejmech.2022.114410
Homo sapiens Monoamine oxidase B IC50 nan None 10.1021/acs.jmedchem.1c00966
Homo sapiens Monoamine oxidase B IC50 nan None 10.1021/jm300978h
Homo sapiens Monoamine oxidase B IC50 nan None 10.1021/jm400567s
Homo sapiens Monoamine oxidase B IC50 nan None 10.1039/C6MD00228E
Homo sapiens Monoamine oxidase B Inhibition 22.6 % 10.1016/j.bmc.2022.116807
Homo sapiens Monoamine oxidase B Inhibition 28.2 % 10.1021/acsmedchemlett.1c00344
Homo sapiens Monoamine oxidase B Inhibition nan % 10.1016/j.bmc.2013.09.050
Homo sapiens Monoamine oxidase B Inhibition nan % 10.1016/j.bmc.2014.12.010
Homo sapiens Monoamine oxidase B Inhibition nan % 10.1016/j.bmc.2016.02.045
Homo sapiens Monoamine oxidase B Inhibition nan % 10.1016/j.bmcl.2021.127993
Homo sapiens Monoamine oxidase B Inhibition nan % 10.1016/j.ejmech.2011.12.027
Homo sapiens Monoamine oxidase B Inhibition nan % 10.1016/j.ejmech.2022.114410
Homo sapiens Monoamine oxidase B Inhibition nan % 10.1021/acs.jmedchem.7b00918
Homo sapiens Monoamine oxidase B Inhibition nan % 10.1021/acs.jnatprod.9b00469
Homo sapiens Monoamine oxidase B Ki nan None 10.1039/C6MD00228E
Homo sapiens Niemann-Pick C1 protein Potency 16360.1 nM None
Homo sapiens N-lysine methyltransferase SETD8 IC50 nan None 10.1016/j.ejmech.2022.114410
Homo sapiens N-lysine methyltransferase SETD8 Inhibition nan % 10.1016/j.ejmech.2022.114410
Homo sapiens Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Potency 2393.4 nM None
Homo sapiens Protein-arginine N-methyltransferase 1 IC50 nan None 10.1016/j.ejmech.2022.114410
Homo sapiens Protein-arginine N-methyltransferase 1 Inhibition nan % 10.1016/j.ejmech.2022.114410
Homo sapiens Ras-related protein Rab-9A Potency 20596.2 nM None
Homo sapiens Regulator of G-protein signaling 4 Potency 532.3 nM None
Homo sapiens Thrombopoietin Potency 3981.1 nM None
Homo sapiens Thyroid stimulating hormone receptor Potency 10000.0 nM None
Homo sapiens U-251 IC50 136000.0 nM 10.1021/acs.jmedchem.1c01726
Homo sapiens U-251 IC50 175000.0 nM 10.1021/acs.jmedchem.1c01726
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 1412.5 nM None
Mus musculus Acetylcholinesterase IC50 nan None 10.1016/j.bmc.2016.11.032
Mus musculus Monoamine oxidase ED50 1.4 umol.kg-1 10.1021/jm00361a017
Mus musculus Monoamine oxidase ED50 2.6 umol.kg-1 10.1021/jm00361a017
Mus musculus Monoamine oxidase ED50 4.5 umol.kg-1 10.1021/jm00361a017
Mus musculus Monoamine oxidase ED50 5.6 umol.kg-1 10.1021/jm00361a017
Mus musculus Monoamine oxidase ED50 65.0 umol.kg-1 10.1021/jm00361a017
Mus musculus Monoamine oxidase Inhibition 17.0 % 10.1021/jm00361a017
Mus musculus Monoamine oxidase A Activity 17.05 nmol 10.1016/j.bmcl.2012.09.089
Mus musculus Monoamine oxidase B Activity 18.16 nmol 10.1016/j.bmcl.2012.09.089
Mus musculus Monoamine oxidase B Inhibition 25.0 % 10.1021/acs.jmedchem.1c01726
Mus musculus Mus musculus Activity nan None 10.1016/j.bmc.2015.04.021
Mus musculus Mus musculus Potentiation 65.0 uM kg-1 10.1021/jm00361a017
Mus musculus Nuclear receptor ROR-gamma Potency 11220.2 nM None
Mus musculus Sigma intracellular receptor 2 Ki 505.0 nM 10.1021/acs.jmedchem.0c01192
Mus musculus Sigma opioid receptor Ki 2.9 nM 10.1021/acs.jmedchem.0c01192
Rattus norvegicus Cytochrome P450 2B1 Ki 1500.0 nM 10.2174/138920005774330639
Rattus norvegicus Cytochrome P450 2B1 kinact 0.28 min-1 10.2174/138920005774330639
Rattus norvegicus Monoamine oxidase IC50 0.7 nM 10.1021/jm00361a017
Rattus norvegicus Monoamine oxidase IC50 680.0 nM 10.1021/jm00361a017
Rattus norvegicus Monoamine oxidase Selectivity 0.006 None 10.1021/jm00061a006
Rattus norvegicus Monoamine oxidase A IC50 0.42 nM 10.1016/j.bmcl.2012.02.090
Rattus norvegicus Monoamine oxidase A IC50 1.2 nM 10.1021/jm00061a006
Rattus norvegicus Monoamine oxidase A IC50 2.9 nM 10.1016/j.bmcl.2014.11.007
Rattus norvegicus Monoamine oxidase A IC50 4.5 nM 10.1016/j.ejmech.2017.10.036
Rattus norvegicus Monoamine oxidase A IC50 8.0 nM 10.1021/acs.jnatprod.8b00677
Rattus norvegicus Monoamine oxidase A IC50 30.0 nM 10.1016/j.ejmech.2014.04.078
Rattus norvegicus Monoamine oxidase A IC50 2050.0 nM 10.1016/j.bmc.2008.11.068
Rattus norvegicus Monoamine oxidase A IC50 2050.0 nM 10.1016/j.bmcl.2008.10.084
Rattus norvegicus Monoamine oxidase A IC50 2720.0 nM 10.1016/j.bmc.2007.06.004
Rattus norvegicus Monoamine oxidase A Ki 1200.0 nM 10.1016/j.bmc.2008.11.068
Rattus norvegicus Monoamine oxidase B IC50 0.5 nM 10.1016/j.bmc.2014.12.063
Rattus norvegicus Monoamine oxidase B IC50 260.0 nM 10.1016/j.bmcl.2012.02.090
Rattus norvegicus Monoamine oxidase B IC50 1900.0 nM 10.1021/jm00061a006
Rattus norvegicus Monoamine oxidase B IC50 8000.0 nM 10.1016/j.ejmech.2014.04.078
Rattus norvegicus Monoamine oxidase B IC50 61350.0 nM 10.1016/j.ejmech.2017.10.036
Rattus norvegicus Monoamine oxidase B IC50 400900.0 nM 10.1016/j.bmc.2007.06.004
Rattus norvegicus Monoamine oxidase B IC50 400900.0 nM 10.1016/j.bmc.2008.11.068
Rattus norvegicus Monoamine oxidase B IC50 400900.0 nM 10.1016/j.bmcl.2008.10.084
Rattus norvegicus Monoamine oxidase B Ki 5600.0 nM 10.1016/j.bmc.2008.11.068
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 14125.4 nM None
Rattus norvegicus Muscarinic acetylcholine receptor M1 Potency 17782.8 nM None
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 16.46 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.41 % 10.6019/CHEMBL4495565
None ADMET MST 11.75 day 10.1021/acs.jmedchem.1c01726
None ADMET MST 13.8 day 10.1021/acs.jmedchem.1c01726
None ADMET MST 14.4 day 10.1021/acs.jmedchem.1c01726
None ADMET MST 17.25 day 10.1021/acs.jmedchem.1c01726
None ADMET Survival 13.8 day 10.1021/acs.jmedchem.1c01726
None ADMET Survival 14.0 day 10.1021/acs.jmedchem.1c01726
None ADMET Survival 15.0 day 10.1021/acs.jmedchem.1c01726
None ADMET Survival 17.0 day 10.1021/acs.jmedchem.1c01726
None ADMET Survival 18.0 day 10.1021/acs.jmedchem.1c01726
None ADMET Survival 19.0 day 10.1021/acs.jmedchem.1c01726
None No relevant target Activity nan None 10.1016/j.bmc.2015.04.009
None No relevant target Activity nan None 10.1016/j.bmc.2020.115374
None No relevant target Activity nan None 10.1016/j.bmc.2021.116074
None No relevant target Activity nan None 10.1016/j.bmcl.2017.01.050
None No relevant target Activity nan None 10.1016/j.ejmech.2017.08.025
None Unchecked Activity nan None 10.1016/j.ejmech.2021.113558
None Unchecked Activity nan None 10.1021/acs.jmedchem.1c01726
None Unchecked IC50 169000.0 nM 10.1021/acs.jmedchem.1c01726
None Unchecked Inhibition nan % 10.1016/j.bmc.2018.01.030
None Unchecked Ki 1990.0 nM 10.1016/j.bmcl.2008.10.084
None Unchecked Potency 1032.3 nM None
None Unchecked Potency 6510.4 nM None
None Unchecked Potency 8912.5 nM None
None Unchecked Potency 9200.0 nM None
None Unchecked Ratio IC50 6.5e-05 None 10.1016/j.bmc.2009.12.029
None Unchecked Ratio IC50 6.5e-05 None 10.1021/jm801496u
None Unchecked Ratio IC50 7e-05 None 10.1016/j.ejmech.2017.10.036
None Unchecked Ratio IC50 7e-05 None 10.1016/j.ejmech.2018.07.056
None Unchecked Ratio IC50 7e-05 None 10.1021/acs.jmedchem.6b00527
None Unchecked Ratio IC50 7e-05 None 10.1021/jm800656v
None Unchecked Ratio IC50 7.1e-05 None 10.1021/jm501501a
None Unchecked Ratio IC50 7.3e-05 None 10.1016/j.bmc.2010.06.007
None Unchecked Ratio IC50 7.3e-05 None 10.1016/j.bmc.2014.03.042
None Unchecked Ratio IC50 7.3e-05 None 10.1016/j.bmcl.2013.07.035
None Unchecked Ratio IC50 7.3e-05 None 10.1016/j.ejmech.2009.11.003
None Unchecked Ratio IC50 7.3e-05 None 10.1016/j.ejmech.2011.07.017
None Unchecked Ratio IC50 7.3e-05 None 10.1016/j.ejmech.2012.11.006
None Unchecked Ratio IC50 7.3e-05 None 10.1016/j.ejmech.2016.03.081
None Unchecked Ratio IC50 7.3e-05 None 10.1021/jm100120s
None Unchecked Ratio IC50 7.3e-05 None 10.1021/jm1013709
None Unchecked Ratio IC50 7.3e-05 None 10.1021/jm800132g
None Unchecked Ratio IC50 7.3e-05 None 10.1021/jm801590u
None Unchecked Ratio IC50 7.4e-05 None 10.1016/j.ejmech.2020.112475
None Unchecked Ratio IC50 8e-05 None 10.1016/j.bmc.2010.05.070
None Unchecked Ratio IC50 8.2e-05 None 10.1016/j.bmcl.2010.03.081
None Unchecked Ratio IC50 8.2e-05 None 10.1039/C7MD00311K
None Unchecked Ratio IC50 0.0001 None 10.1039/C5MD00357A
None Unchecked Ratio IC50 0.00025 None 10.1016/j.bmc.2016.11.032
None Unchecked Ratio IC50 0.0003 None 10.1016/j.bmc.2016.06.045
None Unchecked Ratio IC50 0.0003 None 10.1016/j.ejmech.2020.112911
None Unchecked Ratio IC50 0.0003 None 10.1021/acs.jmedchem.9b01886
None Unchecked Ratio IC50 0.00064 None 10.1016/j.bmc.2016.04.012
None Unchecked Ratio IC50 0.00064 None 10.1016/j.bmc.2016.11.048
None Unchecked Ratio IC50 0.00064 None 10.1016/j.bmc.2016.12.013
None Unchecked Ratio IC50 0.00064 None 10.1016/j.bmc.2018.02.037
None Unchecked Ratio IC50 0.00073 None 10.1016/j.ejmech.2012.10.032
None Unchecked Ratio IC50 0.00089 None 10.1016/j.bmcl.2017.01.050
None Unchecked Ratio IC50 0.001 None 10.1016/j.bmcl.2021.128051
None Unchecked Ratio IC50 0.001 None 10.1016/j.ejmech.2021.113183
None Unchecked Ratio IC50 0.00112 None 10.1016/j.bmc.2017.02.027
None Unchecked Ratio IC50 0.00124 None 10.1016/j.ejmech.2019.111770
None Unchecked Ratio IC50 0.0014 None 10.1021/acs.jmedchem.1c00510
None Unchecked Ratio IC50 0.00162 None 10.1016/j.bmcl.2012.02.090
None Unchecked Ratio IC50 0.0019 None 10.1016/j.bmcl.2019.02.008
None Unchecked Ratio IC50 0.002 None 10.1016/j.bmcl.2019.02.030
None Unchecked Ratio IC50 0.0031 None 10.1016/j.bmc.2016.02.045
None Unchecked Ratio IC50 0.0031 None 10.1016/j.ejmech.2018.01.029
None Unchecked Ratio IC50 0.0042 None 10.1039/C8MD00399H
None Unchecked Ratio IC50 0.0446 None 10.1021/acs.jmedchem.7b00918
None Unchecked Ratio IC50 0.05 None 10.1016/j.ejmech.2015.08.055
None Unchecked Ratio IC50 10.27 None 10.1016/j.ejmech.2020.112265
None Unchecked Ratio IC50 22.06 None 10.1016/j.ejmech.2015.08.055
None Unchecked Ratio IC50 267.0 None 10.1016/j.ejmech.2014.04.078
None Unchecked Ratio IC50 1476.0 None 10.1016/j.bmc.2017.03.070
None Unchecked Ratio IC50 4094.0 None 10.1016/j.ejmech.2015.10.001
None Unchecked Ratio IC50 13698.0 None 10.1039/C0MD00014K
None Unchecked Ratio IC50 15852.0 None 10.1016/j.ejmech.2011.09.045
None Unchecked Ratio IC50 30323.0 None 10.1016/j.ejmech.2015.02.020
None Unchecked Ratio IC50 30323.0 None 10.1016/j.ejmech.2021.114085
None Unchecked Ratio IC50 33793.0 None 10.1016/j.bmc.2015.04.021
None Unchecked Ratio IC50 3032000.0 None 10.1016/j.ejmech.2010.07.008
None Unchecked Ratio IC50 nan None 10.1016/j.bmc.2017.11.036
None Unchecked Ratio IC50 nan None 10.1016/j.bmc.2019.03.060
None Unchecked Ratio IC50 nan None 10.1016/j.bmcl.2022.128746
None Unchecked Ratio IC50 nan None 10.1039/C6MD00228E
None Unchecked Ratio Ki 1070.0 None 10.1021/jm301014y
None Unchecked Ratio Ki 1074.1 None 10.1016/j.bmc.2008.09.072
None Unchecked Ratio Ki 1074.1 None 10.1021/jm060882y
None Unchecked Selectivity Index 7.3e-05 None 10.1016/j.ejmech.2010.07.009
None Unchecked Selectivity Index 0.0001 None 10.1016/j.ejmech.2021.113310
None Unchecked Selectivity Index 0.00085 None 10.1016/j.bmc.2021.116255
None Unchecked Selectivity Index 33790.0 None 10.1016/j.bmcl.2014.11.007
None Unchecked Selectivity Index 30320000.0 None 10.1016/j.ejmech.2015.02.039
None Unchecked Selectivity Index nan None 10.1016/j.ejmech.2020.113112
None Unchecked Selectivity ratio 2400.0 None 10.1016/j.bmc.2014.12.063

Metabolism Information