Sorazinone A
AlkaPlorer ID: AK077442
Synonym: 'Sorazinone A'
IUPAC Name: 4-methyl-1,7-diazatricyclo[7.3.0.03,7]dodeca-3,5,9,11-tetraene-2,8-dione
Structure
SMILES: CC1=C2C(=O)N3C=CC=C3C(=O)N2C=C1
InChI: InChI=1S/C11H8N2O2/c1-7-4-6-13-9(7)11(15)12-5-2-3-8(12)10(13)14/h2-6H,1H3
InChIKey: UMNZUDYDIKGADO-UHFFFAOYSA-N
Reference
Nannozinones and Sorazinones, Unprecedented Pyrazinones from Myxobacteria
PubChem CID: 101889904
LOTUS: LTS0105714
NPASS: NPC472260
COCONUT: CNP0126402
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 200.197
TPSA？: 42.96
MolLogP？: 0.65862
Number of H-Donors: 0
Number of H-Acceptors: 4
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Candida albicans | Candida albicans | MIC | 66.6 | ug.mL-1 | 10.1021/np500632c |
| Chromobacterium violaceum | Chromobacterium violaceum | MIC | 66.6 | ug.mL-1 | 10.1021/np500632c |
| Escherichia coli | Escherichia coli | MIC | 66.6 | ug.mL-1 | 10.1021/np500632c |
| Homo sapiens | A549 | IC50 | 50000.0 | nM | 10.1021/np500632c |
| Homo sapiens | MCF7 | IC50 | 50000.0 | nM | 10.1021/np500632c |
| Mucor hiemalis | Mucor hiemalis | MIC | 66.6 | ug.mL-1 | 10.1021/np500632c |
| Mus musculus | L929 | IC50 | 50000.0 | nM | 10.1021/np500632c |
| Mycolicibacterium diernhoferi | Mycolicibacterium diernhoferi | MIC | 66.6 | ug.mL-1 | 10.1021/np500632c |
| Nocardia sp. | Nocardia sp. | MIC | 16.6 | ug.mL-1 | 10.1021/np500632c |
| Paenibacillus polymyxa | Paenibacillus polymyxa | MIC | 66.6 | ug.mL-1 | 10.1021/np500632c |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | MIC | 66.6 | ug.mL-1 | 10.1021/np500632c |
| Saccharomyces cerevisiae | Saccharomyces cerevisiae | MIC | 66.6 | ug.mL-1 | 10.1021/np500632c |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 66.6 | ug.mL-1 | 10.1021/np500632c |
| Wickerhamomyces anomalus | Wickerhamomyces anomalus | MIC | 66.6 | ug.mL-1 | 10.1021/np500632c |
| None | NON-PROTEIN TARGET | IC50 | 50000.0 | nM | 10.1021/np500632c |
| None | NON-PROTEIN TARGET | MIC | 66.6 | ug.mL-1 | 10.1021/np500632c |