Hippamine
AlkaPlorer ID: AK078321
Synonym: 'O2-Methyllycorine', '2-O-Methyllycorine'
IUPAC Name: (1S,17S,18S,19S)-17-methoxy-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraen-18-ol
Structure
SMILES: CO[C@H]1C=C2CCN3CC4=CC5=C(C=C4[C@H]([C@@H]1O)[C@@H]23)OCO5
InChI: InChI=1S/C17H19NO4/c1-20-14-4-9-2-3-18-7-10-5-12-13(22-8-21-12)6-11(10)15(16(9)18)17(14)19/h4-6,14-17,19H,2-3,7-8H2,1H3/t14-,15-,16+,17+/m0/s1
InChIKey: GYLFSMMPXXYQAB-MWDXBVQZSA-N
Reference
Alkaloids from the Bulbs of Crinum bulbispermum.
PubChem CID: 23259917
LOTUS: LTS0192533
SuperNatural Ⅲ: SN0118687-01
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Sternbergia lutea | Sternbergia | Amaryllidaceae | Asparagales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 301.3420000000001
TPSA？: 51.16000000000001
MolLogP？: 1.4026999999999998
Number of H-Donors: 1
Number of H-Acceptors: 5
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | A549 | GI50 | 31000.0 | nM | 10.1016/j.bmcl.2013.12.073 |
| Homo sapiens | MCF7 | GI50 | 100000.0 | nM | 10.1016/j.bmcl.2013.12.073 |
| Homo sapiens | SK-MEL-28 | GI50 | 92000.0 | nM | 10.1016/j.bmcl.2013.12.073 |
| Homo sapiens | T98G | GI50 | 84000.0 | nM | 10.1016/j.bmcl.2013.12.073 |
| Mus musculus | B16-F10 | GI50 | 40000.0 | nM | 10.1016/j.bmcl.2013.12.073 |
| Solanum tuberosum | Solanum tuberosum | Inhibition | 58.0 | % | 10.1021/np50036a041 |
| None | NON-PROTEIN TARGET | GI50 | 36000.0 | nM | 10.1016/j.bmcl.2013.12.073 |