Clausine C
AlkaPlorer ID: AK079819
Synonym: None
IUPAC Name: methyl 7-methoxy-9H-carbazole-3-carboxylate
Structure
SMILES: COC(=O)C1=CC=C2NC3=CC(OC)=CC=C3C2=C1
InChI: InChI=1S/C15H13NO3/c1-18-10-4-5-11-12-7-9(15(17)19-2)3-6-13(12)16-14(11)8-10/h3-8,16H,1-2H3
InChIKey: UHYHEIKZOWURQD-UHFFFAOYSA-N
Reference
Alkaloidal and other constituents from the root bark of Clausena excavata
PubChem CID: 11817681
CAS: 186002-61-9
LOTUS: LTS0234143
COCONUT: CNP0269648
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Clausena excavata | Clausena | Rutaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 255.273
TPSA？: 51.32000000000001
MolLogP？: 3.1163000000000007
Number of H-Donors: 1
Number of H-Acceptors: 3
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Escherichia coli | Escherichia coli | MIC | nan | None | 10.1021/np3000365 |
| Homo sapiens | KB | IC50 | nan | None | 10.1021/np3000365 |
| Homo sapiens | Kinesin-like protein 1 | Inhibition | 15.0 | % | 10.1021/jm100476d |
| Homo sapiens | MCF7 | IC50 | nan | None | 10.1021/np3000365 |
| Homo sapiens | NCI-H187 | IC50 | nan | None | 10.1021/np3000365 |
| Mycobacterium tuberculosis | Mycobacterium tuberculosis | MIC90 | 128000.0 | nM | 10.1007/s00044-007-9073-0 |
| Salmonella enterica subsp. enterica serovar Typhimurium | Salmonella typhimurium | MIC | 128.0 | ug.mL-1 | 10.1021/np3000365 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | nan | None | 10.1021/np3000365 |