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name Structure Reference Source Properties Activities Metabolism

2-Quinolinamine

AlkaPlorer ID: AK081125

Synonym: 2-Aminoquinoline, α-Aminoquinoline

IUPAC Name: quinolin-2-amine

Structure

SMILES: N=C1C=CC2=CC=CC=C2N1

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InChI: InChI=1S/C9H8N2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H,(H2,10,11)

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InChIKey: GCMNJUJAKQGROZ-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Leucopaxillus albissimus Leucopaxillus Tricholomataceae Agaricales Agaricomycetes Basidiomycota Fungi Eukaryota

Properties Information

Molecule Weight: 144.177

TPSA？: 39.64

MolLogP？: 1.6473699999999998

Number of H-Donors: 2

Number of H-Acceptors: 1

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Aspergillus inflatus Aspergillus inflatus IZ 6.0 mm 10.1021/np50059a027
Flavobacterium johnsoniae Flavobacterium johnsoniae IZ 16.0 mm 10.1021/np50059a027
Homo sapiens Beta-secretase 1 IC50 800000.0 nM 10.1021/jm200544q
Homo sapiens Beta-secretase 1 IC50 2000000.0 nM 10.1021/jm061197u
Homo sapiens Beta-secretase 1 Inhibition 30.0 % 10.1021/jm0611962
Homo sapiens Beta-secretase 1 Kd 900000.0 nM 10.1021/jm200544q
Homo sapiens Beta-secretase 1 Kd 900000.0 nM 10.1021/jm201441k
Homo sapiens Glutaminyl-peptide cyclotransferase IC50 nan None 10.1021/acsmedchemlett.2c00256
Homo sapiens HepG2 Potency 3548.1 nM None
Homo sapiens Mothers against decapentaplegic homolog 3 Potency 5623.4 nM None
Homo sapiens Nck adaptor protein 1 EC50 150000.0 nM 10.1021/jm049533z
Homo sapiens Neutrophil cytosol factor 1 Activity nan None 10.1021/acs.jmedchem.9b01492
Homo sapiens Neutrophil cytosol factor 1 Delta Tm 0.3 degrees C 10.1021/acs.jmedchem.9b01492
Homo sapiens Neutrophil cytosol factor 1 Delta Tm 0.6 degrees C 10.1021/acs.jmedchem.9b01492
Homo sapiens Neutrophil cytosol factor 1 Delta Tm 1.2 degrees C 10.1021/acs.jmedchem.9b01492
Homo sapiens Neutrophil cytosol factor 1 Delta Tm 2.0 degrees C 10.1021/acs.jmedchem.9b01492
Homo sapiens Neutrophil cytosol factor 1 Inhibition 5.0 % 10.1021/acs.jmedchem.9b01492
Homo sapiens Neutrophil cytosol factor 1 Inhibition 25.0 % 10.1021/acs.jmedchem.9b01492
Homo sapiens Neutrophil cytosol factor 1 Kd 488000.0 nM 10.1021/acs.jmedchem.9b01492
Homo sapiens Neutrophil cytosol factor 1 Ki 428000.0 nM 10.1021/acs.jmedchem.9b01492
Homo sapiens Nitric-oxide synthase, brain IC50 nan nM 10.1016/s0960-894x(00)00389-9
Homo sapiens Nitric-oxide synthase, endothelial IC50 nan nM 10.1016/s0960-894x(00)00389-9
Homo sapiens Nitric oxide synthase, inducible IC50 1700.0 nM 10.1016/s0960-894x(00)00389-9
Homo sapiens Nitric oxide synthase (inducible and endothelial) Selectivity nan None 10.1016/s0960-894x(00)00389-9
Homo sapiens Nitric oxide sythases; iNOS & nNOS Selectivity nan None 10.1016/s0960-894x(00)00389-9
Homo sapiens Tyrosine-protein kinase FYN EC50 nan nM 10.1021/jm049533z
Homo sapiens Tyrosine-protein kinase HCK EC50 1000000.0 nM 10.1021/jm049533z
Mus musculus Tyrosine-protein kinase TEC EC50 160000.0 nM 10.1021/jm049533z
Mus musculus Tyrosine-protein kinase TEC Kd 125000.0 nM 10.1021/jm049533z
Nippostrongylus brasiliensis Nippostrongylus brasiliensis Activity 50.0 % 10.1021/np50059a027
Nippostrongylus brasiliensis Nippostrongylus brasiliensis Activity 52.0 % 10.1021/np50059a027
Nippostrongylus brasiliensis Nippostrongylus brasiliensis Activity 74.0 % 10.1021/np50059a027
Plasmodium falciparum Ferriprotoporphyrin IX Log K 4.23 None 10.1021/jm990437l
Plasmodium falciparum Histidine-rich protein NI nan None 10.1021/jm990437l
Plasmodium falciparum Plasmodium falciparum IC50 10000.0 nM 10.1021/jm990437l
Rattus norvegicus Serotonin 2 (5-HT2) receptor Ki 79000.0 nM 10.1021/jm00161a038
Streptomyces galilaeus Streptomyces galilaeus IZ 6.0 mm 10.1021/np50059a027
None ADMET pKa 7.3 None 10.1021/jm00128a041
None No relevant target LogD7.4 1.7 None 10.6019/CHEMBL3301361
None No relevant target pKa 7.34 None 10.1021/jm049533z
None No relevant target pKa_B1 7.2 None 10.6019/CHEMBL3301361
None Nucleic Acid Activity nan None 10.1021/jm9000659
None Unchecked Ki 28600.0 nM 10.1021/jm00161a038

Metabolism Information