Molecule

Deoxyfuconojirimycin

AlkaPlorer ID: AK082230

Synonym: None

IUPAC Name: (2S,3R,4S,5R)-2-methylpiperidine-3,4,5-triol

Structure

SMILES: C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O

InChI: InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5+,6-/m0/s1

InChIKey: VYOCYWDJTQRZLC-KCDKBNATSA-N

Reference

Characterization of a new α-l-fucosidase isolated from Fusarium proliferatum LE1 that is regioselective to α-(1 → 4)-l-fucosidic linkage in the hydrolysis of α-l-fucobiosides

PubChem CID: 122618

CAS: 6312-10-3

LOTUS: LTS0264779

NPASS: NPC204709

Source

Species	Genus	Family	Order	Class	Phylum	Kingdom	Domain
Morus alba	Morus	Moraceae	Rosales	Magnoliopsida	Streptophyta	Viridiplantae	Eukaryota
Fusarium proliferatum	Fusarium	Nectriaceae	Hypocreales	Sordariomycetes	Ascomycota	Fungi	Eukaryota

Properties Information

Molecule Weight: 147.17399999999998

TPSA？: 72.72

MolLogP？: -1.9392

Number of H-Donors: 4

Number of H-Acceptors: 4

RingCount: 1

Activities Information

Organism	Target Name	Standard Type	Standard Value	Standard Units	doi
Bos taurus	Alpha-L-fucosidase 1	IC50	5.0	nM	10.1016/j.bmcl.2005.11.100
Bos taurus	Alpha-L-fucosidase 1	IC50	110.0	nM	10.1016/j.bmc.2013.08.028
Bos taurus	Alpha-L-fucosidase 1	Ki	1.7	nM	10.1021/jm0495881
Bos taurus	Alpha-L-fucosidase 1	Ki	3.0	nM	10.1016/j.bmc.2009.10.010
Bos taurus	Alpha-L-fucosidase 1	Ki	3.0	nM	10.1016/j.bmcl.2005.11.100
Bos taurus	Beta-galactosidase	IC50	nan	nM	10.1016/s0960-894x(02)00627-3
Bos taurus	Beta-galactosidase	Inhibition	3.7	%	10.1016/j.bmc.2013.08.028
Coffea arabica	Alpha-galactosidase	Inhibition	5.2	%	10.1016/j.bmc.2013.08.028
Homo sapiens	Alpha-galactosidase A	Inhibition	74.0	%	10.1016/S0960-894X(01)80711-3
Homo sapiens	Alpha-L-fucosidase 2	Ki	9.8	nM	10.1016/S0960-894X(01)80711-3
Homo sapiens	Alpha-L-fucosidase I	IC50	140.0	nM	10.1016/j.bmc.2013.08.028
Homo sapiens	Alpha-L-fucosidase I	IC50	140.0	nM	10.1021/acs.jmedchem.1c01673
Homo sapiens	Alpha-L-fucosidase I	IC50	410.0	nM	10.1016/s0960-894x(02)00627-3
Homo sapiens	Alpha-L-fucosidase I	Inhibition	99.0	%	10.1016/S0960-894X(01)80711-3
Homo sapiens	Alpha-L-fucosidase I	Ki	6.2	nM	10.1016/0960-894X(95)00377-6
Homo sapiens	Alpha-L-fucosidase I	Ki	6.2	nM	10.1016/S0960-894X(01)80711-3
Homo sapiens	Alpha-L-fucosidase I	Ki	6.2	nM	10.1016/s0960-894x(98)00596-4
Homo sapiens	Alpha-L-fucosidase I	Ki	10.0	nM	10.1016/j.bmcl.2006.01.095
Homo sapiens	Alpha-L-fucosidase I	Ki	29.0	nM	10.1016/S0960-894X(00)80649-6
Homo sapiens	Alpha-L-fucosidase I	Ki	31.0	nM	10.1016/s0960-894x(02)00627-3
Homo sapiens	Alpha-L-fucosidase I	Ki	80.0	nM	10.1021/jm970836l
Rattus norvegicus	Alpha-L-fucosidase I	IC50	340.0	nM	10.1016/j.bmc.2013.08.028
None	Unchecked	IC50	3500000.0	nM	10.1016/S0960-894X(97)00189-3
None	Unchecked	Inhibition	2.3	%	10.1016/j.bmc.2013.08.028
None	Unchecked	Inhibition	2.6	%	10.1016/j.bmc.2013.08.028
None	Unchecked	Inhibition	4.9	%	10.1016/j.bmc.2013.08.028
None	Unchecked	Inhibition	5.7	%	10.1016/j.bmc.2013.08.028
None	Unchecked	Inhibition	7.4	%	10.1016/j.bmc.2013.08.028
None	Unchecked	Inhibition	50.0	%	10.1016/S0960-894X(01)80711-3
None	Unchecked	Inhibition	83.0	%	10.1016/S0960-894X(01)80711-3
None	Unchecked	Ki	nan	None	10.1016/j.bmc.2009.10.010