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Olomoucine

AlkaPlorer ID: AK086749

Synonym: 2-[[9-Methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]ethanol, 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine 

IUPAC Name: 2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol

Structure

SMILES: CN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C21

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InChI: InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)

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InChIKey: GTVPOLSIJWJJNY-UHFFFAOYSA-N

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Reference

PubChem CID: 4592

CAS: 101622-51-9

SuperNatural Ⅲ: SN0115206

COCONUT: CNP0115764

Source

Species Genus Family Order Class Phylum Kingdom Domain
Raphanus sativus Raphanus Brassicaceae Brassicales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 298.35

TPSA？: 87.89

MolLogP？: 1.3795999999999995

Number of H-Donors: 3

Number of H-Acceptors: 7

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus anthracis Anthrax lethal factor Potency 12589.3 nM None
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens 786-0 GI50 60673.63 nM None
Homo sapiens A-431 GI50 16600.0 nM 10.1016/j.ejmech.2011.09.041
Homo sapiens A498 GI50 102801.63 nM None
Homo sapiens A549 GI50 43853.07 nM None
Homo sapiens A549 IC50 57.0 ug.mL-1 10.1016/s0960-894x(00)00014-7
Homo sapiens A549 IC50 130000.0 nM 10.1016/j.ejmech.2013.07.003
Homo sapiens ACHN GI50 35892.19 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 44668.4 nM None
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Arachidonate 15-lipoxygenase Potency 15848.9 nM None
Homo sapiens BT-549 GI50 53088.44 nM None
Homo sapiens CAKI-1 GI50 33651.16 nM None
Homo sapiens CaM kinase I delta Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase I gamma Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II alpha Thermal melting change -0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II beta Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II delta Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II gamma Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase IV Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM-kinase kinase beta Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase (PKA) IC50 2000000.0 nM 10.1021/jm011002c
Homo sapiens Casein kinase I gamma 1 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase I gamma 2 Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase I isoform gamma-3 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CCRF-CEM GI50 54575.79 nM None
Homo sapiens CCRF-CEM IC50 62000.0 nM 10.1016/s0960-894x(02)00693-5
Homo sapiens CDK6/cyclin D3 IC50 250000.0 nM 10.1073/pnas.0708800104
Homo sapiens Cerebroside-sulfatase Potency 5358.2 nM None
Homo sapiens COLO 205 GI50 30130.06 nM None
Homo sapiens Cyclin-dependent kinase 1 IC50 4600.0 nM 10.1021/jm990506w
Homo sapiens Cyclin-dependent kinase 1 IC50 6000.0 nM 10.1021/jm960666x
Homo sapiens Cyclin-dependent kinase 1 IC50 7000.0 nM 10.1021/jm000965t
Homo sapiens Cyclin-dependent kinase 1 IC50 7000.0 nM 10.1208/aapsj080125
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 7000.0 nM 10.1016/s0960-894x(02)00693-5
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 7000.0 nM 10.1016/s0960-894x(03)00631-0
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 7000.0 nM 10.1021/jm011002c
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 7000.0 nM 10.1021/jm9911130
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 163000.0 nM 10.1016/s0960-894x(03)00631-0
Homo sapiens Cyclin-dependent kinase 1/cyclin B ID50 7.0 uM 10.1021/jm991182e
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 GI 50.0 % 10.1016/j.ejmech.2009.11.049
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 7000.0 nM 10.1016/j.bmc.2017.10.012
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 7000.0 nM 10.1016/j.ejmech.2009.10.002
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 7000.0 nM 10.1016/j.ejmech.2010.06.034
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 7000.0 nM 10.1016/s0960-894x(98)00097-3
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 7000.0 nM 10.1021/jm000231g
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 7000.0 nM 10.1021/jm0700666
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Inhibition 48.0 % 10.1016/j.ejmech.2009.10.002
Homo sapiens Cyclin-dependent kinase 2 IC50 1200.0 nM 10.1021/jm990506w
Homo sapiens Cyclin-dependent kinase 2 IC50 7000.0 nM 10.1016/j.bmc.2008.02.046
Homo sapiens Cyclin-dependent kinase 2 IC50 7000.0 nM 10.1016/j.ejmech.2013.07.003
Homo sapiens Cyclin-dependent kinase 2 IC50 7000.0 nM 10.1016/s0960-894x(00)00014-7
Homo sapiens Cyclin-dependent kinase 2 IC50 7000.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Cyclin-dependent kinase 2 IC50 7000.0 nM 10.1208/aapsj080125
Homo sapiens Cyclin-dependent kinase 2 Ki 3981.07 nM None
Homo sapiens Cyclin-dependent kinase 2 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 7000.0 nM 10.1016/j.ejmech.2009.12.026
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 7000.0 nM 10.1016/j.ejmech.2011.09.041
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 7000.0 nM 10.1021/jm011002c
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 10000.0 nM 10.1016/j.bmcl.2009.10.025
Homo sapiens Cyclin-dependent kinase 2/cyclin A Inhibition 43.0 % 10.1016/j.ejmech.2009.10.002
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 5.0 ug.mL-1 10.1016/j.ejmech.2017.08.009
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 5000.0 nM 10.1021/jm0605740
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 7000.0 nM 10.1016/S0960-894X(97)10076-2
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 7000.0 nM 10.1021/jm000231g
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 7000.0 nM 10.1021/jm011002c
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 10000.0 nM 10.1016/j.bmcl.2009.10.025
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 10000.0 nM 10.1016/s0960-894x(00)00357-7
Homo sapiens Cyclin-dependent kinase 2/cyclin E ID50 7.0 uM 10.1021/jm991182e
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 GI 51.0 % 10.1016/j.ejmech.2009.11.049
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 5000.0 nM 10.1016/j.bmc.2012.06.056
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 7079.46 nM 10.1016/j.ejmech.2015.12.023
Homo sapiens Cyclin-dependent kinase 4 IC50 100000.0 nM 10.1208/aapsj080125
Homo sapiens Cyclin-dependent kinase 4 IC50 200000.0 nM 10.1016/s0960-894x(00)00014-7
Homo sapiens Cyclin-dependent kinase 4/cyclin D IA nan None 10.1021/jm991182e
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 1000000.0 nM 10.1021/jm000231g
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 1000000.0 nM 10.1021/jm011002c
Homo sapiens Cyclin-dependent kinase 5 IC50 3000.0 nM 10.1021/jm000965t
Homo sapiens Cyclin-dependent kinase 5 IC50 3000.0 nM 10.1208/aapsj080125
Homo sapiens Cyclin-dependent kinase 5 Ki 6309.57 nM None
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 7000.0 nM 10.1016/s0960-894x(02)00094-x
Homo sapiens Cyclin-dependent kinase 6 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase-like 1 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Cytochrome P450 1A2 AC50 5011.87 nM None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 AC50 1258.93 nM None
Homo sapiens Cytochrome P450 2D6 Potency 1258.9 nM None
Homo sapiens Cytochrome P450 2D6 Potency 3162.3 nM None
Homo sapiens Cytochrome P450 3A4 AC50 15848.93 nM None
Homo sapiens Cytochrome P450 3A4 Potency 15848.9 nM None
Homo sapiens Death-associated protein kinase 3 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dopamine D1 receptor Potency 3.7 nM None
Homo sapiens DU-145 GI50 34119.29 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Thermal melting change -0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity protein kinase CLK2 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity protein kinase CLK3 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificty protein kinase CLK1 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens EKVX GI50 94406.09 nM None
Homo sapiens Epidermal growth factor receptor erbB1 IC50 440000.0 nM 10.1021/jm000231g
Homo sapiens G-361 IC50 147000.0 nM 10.1021/jm0605740
Homo sapiens G-361 IC50 160000.0 nM 10.1016/s0960-894x(02)00693-5
Homo sapiens Glycogen synthase kinase-3 beta Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens HCC 2998 GI50 79067.86 nM None
Homo sapiens HCT-116 GI50 34753.62 nM None
Homo sapiens HCT-15 GI 28.9 % 10.1016/j.ejmech.2009.11.049
Homo sapiens HCT-15 GI50 41304.75 nM None
Homo sapiens HCT-15 IC50 62500.0 nM 10.1016/j.ejmech.2009.11.049
Homo sapiens HepG2 IC50 nan ug.mL-1 10.1016/s0960-894x(00)00014-7
Homo sapiens Histone deacetylase 6 Inhibition 4.29 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 11.41 % 10.6019/CHEMBL4808148
Homo sapiens HL-60 GI50 36897.76 nM None
Homo sapiens HL-60 IC50 50.0 ug.mL-1 10.1016/s0960-894x(00)00014-7
Homo sapiens HOP-62 GI50 29308.93 nM None
Homo sapiens HOP-92 GI50 61235.04 nM None
Homo sapiens HOS IC50 144000.0 nM 10.1021/jm0605740
Homo sapiens HOS IC50 149000.0 nM 10.1016/s0960-894x(02)00693-5
Homo sapiens Hs-578T GI50 69502.43 nM None
Homo sapiens HT-29 GI50 71449.63 nM None
Homo sapiens IGROV-1 GI50 42266.86 nM None
Homo sapiens Inactive serine/threonine-protein kinase VRK3 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens K562 GI 19.8 % 10.1016/j.ejmech.2009.11.049
Homo sapiens K562 GI50 106905.49 nM None
Homo sapiens K562 IC50 89300.0 nM 10.1016/j.ejmech.2009.11.049
Homo sapiens K562 IC50 145000.0 nM 10.1021/jm0605740
Homo sapiens K562 IC50 163000.0 nM 10.1016/j.bmc.2017.10.012
Homo sapiens K562 IC50 167000.0 nM 10.1016/s0960-894x(02)00693-5
Homo sapiens KM12 GI50 34994.52 nM None
Homo sapiens LOX IMVI GI50 23988.33 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 25118.9 nM None
Homo sapiens Lysosomal alpha-glucosidase Potency 14125.4 nM None
Homo sapiens M14 GI50 78886.01 nM None
Homo sapiens Malme-3M GI50 98174.79 nM None
Homo sapiens MAP kinase ERK1 IC50 25000.0 nM 10.1016/j.bmc.2008.02.046
Homo sapiens MAP kinase ERK1 IC50 30000.0 nM 10.1021/jm011002c
Homo sapiens MAP kinase ERK1 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase ERK2 IC50 7000.0 nM 10.1021/jm011002c
Homo sapiens MAP kinase p38 beta Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens MCF7 Activity 15.0 % 10.1016/j.ejmech.2009.11.049
Homo sapiens MCF7 Activity 15.1 % 10.1016/j.ejmech.2009.10.002
Homo sapiens MCF7 Activity 23.2 % 10.1016/j.ejmech.2009.10.002
Homo sapiens MCF7 Activity 23.2 % 10.1016/j.ejmech.2009.11.049
Homo sapiens MCF7 Activity 60.6 % 10.1016/j.ejmech.2009.10.002
Homo sapiens MCF7 Activity 60.6 % 10.1016/j.ejmech.2009.11.049
Homo sapiens MCF7 GI 37.6 % 10.1016/j.ejmech.2009.11.049
Homo sapiens MCF7 GI50 39719.15 nM None
Homo sapiens MCF7 IC50 55900.0 nM 10.1016/j.ejmech.2009.11.049
Homo sapiens MCF7 IC50 130000.0 nM 10.1016/j.bmc.2012.06.056
Homo sapiens MCF7 IC50 132000.0 nM 10.1016/s0960-894x(02)00693-5
Homo sapiens MCF7 IC50 134000.0 nM 10.1021/jm0605740
Homo sapiens MCF7 IC50 142000.0 nM 10.1016/j.ejmech.2013.07.003
Homo sapiens MDA-MB-231 GI50 92682.98 nM None
Homo sapiens MDA-MB-435 GI50 78704.58 nM None
Homo sapiens MDA-N GI50 79432.82 nM None
Homo sapiens Microtubule-associated protein tau Potency 44668.4 nM None
Homo sapiens Mitogen-activated protein kinase 6 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens MOLT-4 GI50 70145.53 nM None
Homo sapiens Myotonin-protein kinase Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens NCI/ADR-RES GI50 93756.2 nM None
Homo sapiens NCI-H226 GI50 51286.14 nM None
Homo sapiens NCI-H23 GI50 59566.21 nM None
Homo sapiens NCI-H322M GI50 76383.58 nM None
Homo sapiens NCI-H460 GI50 104472.02 nM None
Homo sapiens NCI-H522 GI50 51404.37 nM None
Homo sapiens Nuclear factor NF-kappa-B p105 subunit Potency 6309.6 nM None
Homo sapiens OVCAR-3 GI50 20749.14 nM None
Homo sapiens OVCAR-4 GI50 94188.96 nM None
Homo sapiens OVCAR-5 GI50 52966.34 nM None
Homo sapiens OVCAR-8 GI50 66221.65 nM None
Homo sapiens PC-3 GI 22.7 % 10.1016/j.ejmech.2009.11.049
Homo sapiens PC-3 GI50 98174.79 nM None
Homo sapiens PC-3 IC50 81000.0 nM 10.1016/j.ejmech.2009.11.049
Homo sapiens PDZ-binding kinase Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens RPMI-8226 GI50 53826.98 nM None
Homo sapiens RXF 393 GI50 66988.46 nM None
Homo sapiens Serine/threonine-protein kinase 10 Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 16 Thermal melting change 0.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 17A Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 2 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 25 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 38 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase Chk2 Thermal melting change -0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST1 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase NEK2 Thermal melting change 1.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase NEK6 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase OSR1 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK 4 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK6 Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK7 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Thermal melting change -0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM1 Thermal melting change -1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM2 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM3 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK1 Thermal melting change -0.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK4 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase RIO2 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase VRK1 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase VRK2 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens SF-268 GI50 48977.88 nM None
Homo sapiens SF-295 GI50 41114.97 nM None
Homo sapiens SF-539 GI50 42169.65 nM None
Homo sapiens SK-LU-1 Activity 19.7 % 10.1016/j.ejmech.2009.10.002
Homo sapiens SK-LU-1 Activity 19.7 % 10.1016/j.ejmech.2009.11.049
Homo sapiens SK-LU-1 Activity 31.8 % 10.1016/j.ejmech.2009.10.002
Homo sapiens SK-LU-1 Activity 31.8 % 10.1016/j.ejmech.2009.11.049
Homo sapiens SK-LU-1 Activity 44.2 % 10.1016/j.ejmech.2009.10.002
Homo sapiens SK-LU-1 Activity 44.2 % 10.1016/j.ejmech.2009.11.049
Homo sapiens SK-LU-1 GI 36.9 % 10.1016/j.ejmech.2009.11.049
Homo sapiens SK-LU-1 IC50 68100.0 nM 10.1016/j.ejmech.2009.11.049
Homo sapiens SK-MEL-2 GI50 98855.31 nM None
Homo sapiens SK-MEL-28 GI50 52844.53 nM None
Homo sapiens SK-MEL-5 GI50 40550.85 nM None
Homo sapiens SK-OV-3 GI50 95499.26 nM None
Homo sapiens SN12C GI50 90157.11 nM None
Homo sapiens SNB-19 GI50 48640.72 nM None
Homo sapiens SNB-75 GI50 21281.39 nM None
Homo sapiens SNU-638 GI50 12050.0 nM 10.1016/j.ejmech.2011.09.041
Homo sapiens SNU-638 GI50 16620.0 nM 10.1016/j.ejmech.2011.09.041
Homo sapiens SR GI50 29716.66 nM None
Homo sapiens Survival motor neuron protein Potency 891.3 nM None
Homo sapiens Survival motor neuron protein Potency 25118.9 nM None
Homo sapiens Survival motor neuron protein Potency 31622.8 nM None
Homo sapiens SW-620 GI50 43451.02 nM None
Homo sapiens T47D GI50 50466.13 nM None
Homo sapiens TK-10 GI50 63826.35 nM None
Homo sapiens TRAF2- and NCK-interacting kinase Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine-protein kinase JAK1 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 89.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 18356.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 26608.6 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29092.9 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29855.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 39810.7 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 50118.7 nM None
Homo sapiens U-251 GI 32.0 % 10.1016/j.ejmech.2009.11.049
Homo sapiens U-251 GI50 64416.93 nM None
Homo sapiens U-251 IC50 81500.0 nM 10.1016/j.ejmech.2009.11.049
Homo sapiens UACC-257 GI50 95279.62 nM None
Homo sapiens UACC-62 GI50 32583.67 nM None
Homo sapiens UO-31 GI50 31405.09 nM None
Homo sapiens Voltage-gated N-type calcium channel alpha-1B subunit EC50 1000000.0 nM 10.1021/ml3002083
Human betaherpesvirus 5 Human betaherpesvirus 5 Inhibition 50.0 % 10.1021/acs.jmedchem.0c01467
Mus musculus B16-F10 IC50 105000.0 nM 10.1016/j.bmc.2012.06.056
Plasmodium falciparum Plasmodium falciparum IC50 2700.0 nM 10.1021/jm0300983
Plasmodium falciparum Plasmodium falciparum IC50 3000.0 nM 10.1016/j.bmc.2010.01.068
Plasmodium falciparum Plasmodium falciparum IC50 6309.57 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 8000.0 nM 10.1021/jm0300983
Plasmodium falciparum Plasmodium falciparum IC50 10000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum Potency 8275.3 nM None
Plasmodium falciparum Plasmodium falciparum Potency 9285.0 nM None
Plasmodium falciparum Protein kinase Pfmrk IC50 1000000.0 nM 10.1021/jm0300983
Plasmodium falciparum Protein kinase Pfmrk IC50 1100000.0 nM 10.1021/jm040108f
Rattus norvegicus Protein kinase C (PKC) IC50 1000000.0 nM 10.1021/jm000231g
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 2.494 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.0 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 4.05 % 10.21203/rs.3.rs-23951/v1
Simplexvirus Simplexvirus IC50 100000.0 nM 10.1016/j.bmc.2008.11.075
None COLO1 IC50 87.0 ug.mL-1 10.1016/s0960-894x(00)00014-7
None NON-PROTEIN TARGET GI50 65000.0 nM 10.1016/j.bmcl.2009.10.025
None NON-PROTEIN TARGET IC50 132000.0 nM 10.1016/j.ejmech.2013.07.003
None NON-PROTEIN TARGET Potency 794.3 nM None
None NON-PROTEIN TARGET Potency 2818.4 nM None
None NON-PROTEIN TARGET Potency 4466.8 nM None
None NON-PROTEIN TARGET Potency 6309.6 nM None
None NON-PROTEIN TARGET Potency 8912.5 nM None
None Unchecked CC50 15000.0 nM 10.1021/acs.jmedchem.0c01467
None Unchecked IC50 3000.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 7000.0 nM 10.1016/j.bmc.2008.02.046
None Unchecked IC50 7000.0 nM 10.1021/jm058013g
None Unchecked IC50 7000.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 25000.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 30000.0 nM 10.1021/jm000231g
None Unchecked IC50 45000.0 nM 10.1016/j.ejmech.2011.09.041
None Unchecked IC50 1000000.0 nM 10.1021/jm0704090
None Unchecked IC50 1000000.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 2000000.0 nM 10.1021/jm000231g
None Unchecked IC50 2000000.0 nM 10.1021/jm011002c
None Unchecked Inhibition 79.7 % 10.1016/j.bmc.2008.02.046
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Ki 1800000.0 nM 10.1016/j.bmc.2008.02.046
None Unchecked Potency 2238.7 nM None
None Unchecked Potency 14575.0 nM None

Metabolism Information