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name Structure Reference Source Properties Activities Metabolism

2-butyl-3-{[2'-(2H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one

AlkaPlorer ID: AK089837

Synonym: None

IUPAC Name: 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one

Structure

SMILES: CCCCC1=NC2(CCCC2)C(=O)N1CC1=CC=C(C2=CC=CC=C2C2=NNN=N2)C=C1

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InChI: InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

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InChIKey: YOSHYTLCDANDAN-UHFFFAOYSA-N

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Reference

PubChem CID: 3749

CAS: 138402-11-6

NPASS: NPC478922

COCONUT: CNP0268007

Source

Species Genus Family Order Class Phylum Kingdom Domain
Rhus chinensis Rhus Anacardiaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 428.5400000000001

TPSA？: 87.13000000000001

MolLogP？: 4.777400000000004

Number of H-Donors: 1

Number of H-Acceptors: 5

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 6.33 % 10.6019/CHEMBL4513141
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Candida albicans Candida albicans Inhibition -0.2 % 10.6019/CHEMBL4513141
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki nan None None
Cercopithecidae Monkey Delta MAP 9.0 mmHg 10.1016/S0960-894X(01)81139-2
Cercopithecidae Monkey Delta MAP 15.0 mmHg 10.1016/S0960-894X(01)81139-2
Cercopithecidae Monkey Delta MAP 18.0 mmHg 10.1016/S0960-894X(01)81139-2
Cercopithecidae Monkey Delta MAP 23.0 mmHg 10.1016/S0960-894X(01)81139-2
Cercopithecidae Monkey Delta MAP 25.0 mmHg 10.1016/S0960-894X(01)81139-2
Cercopithecidae Monkey Delta MAP 33.0 mmHg 10.1016/S0960-894X(01)81139-2
Chlorocebus aethiops COS-7 Activity nan None 10.1016/j.ejmech.2020.112258
Cryptococcus neoformans Cryptococcus neoformans Inhibition 0.28 % 10.6019/CHEMBL4513141
Danio rerio Danio rerio Activity 15.0 % 10.1021/acs.jnatprod.9b00857
Danio rerio Danio rerio Activity 25.0 % 10.1021/acs.jnatprod.9b00857
Danio rerio Danio rerio Activity 30.0 % 10.1021/acs.jnatprod.9b00857
Danio rerio Danio rerio Activity 36.0 % 10.1021/acs.jnatprod.9b00857
Escherichia coli Escherichia coli Inhibition -3.35 % 10.6019/CHEMBL4513141
Hepatitis B virus Hepatitis B virus IC50 3300.0 nM 10.1021/acs.jmedchem.6b01442
Hepatitis delta virus Hepatitis delta virus EC50 9400.0 nM 10.1021/acs.jmedchem.2c01097
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Adenosine A1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A1 receptor IC50 nan None None
Homo sapiens Adenosine A1 receptor Ki nan None None
Homo sapiens Adenosine A2a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor IC50 nan None None
Homo sapiens Adenosine A2a receptor Ki nan None None
Homo sapiens Adenosine A3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Adhesion G-protein coupled receptor F1 %Inhib (Mean) -34.59 % 10.6019/CHEMBL5209801
Homo sapiens Adhesion G-protein coupled receptor F1 %Inhib (Mean) -32.35 % 10.6019/CHEMBL5209801
Homo sapiens Adhesion G-protein coupled receptor F1 %Inhib (Mean) -19.59 % 10.6019/CHEMBL5209801
Homo sapiens Adhesion G-protein coupled receptor F1 %Inhib (Mean) 6.75 % 10.6019/CHEMBL5209801
Homo sapiens Adhesion G-protein coupled receptor F1 %Max (Mean) 13.92 % 10.6019/CHEMBL5209801
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor %Inhib (Mean) -48.3 % 10.6019/CHEMBL5209801
Homo sapiens Alpha-2a adrenergic receptor %Inhib (Mean) -34.75 % 10.6019/CHEMBL5209801
Homo sapiens Alpha-2a adrenergic receptor %Inhib (Mean) -24.13 % 10.6019/CHEMBL5209801
Homo sapiens Alpha-2a adrenergic receptor %Inhib (Mean) -16.29 % 10.6019/CHEMBL5209801
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor %Max (Mean) 5.4 % 10.6019/CHEMBL5209801
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens Angiotensin II receptor IC50 3.0 nM 10.1021/jm9904147
Homo sapiens Angiotensin II type 2 (AT-2) receptor AC50 95999.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor AC50 100000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Apelin receptor %Inhib (Mean) -39.32 % 10.6019/CHEMBL5209801
Homo sapiens Apelin receptor %Inhib (Mean) 7.31 % 10.6019/CHEMBL5209801
Homo sapiens Apelin receptor %Inhib (Mean) 14.97 % 10.6019/CHEMBL5209801
Homo sapiens Apelin receptor %Inhib (Mean) 24.37 % 10.6019/CHEMBL5209801
Homo sapiens Apelin receptor %Max (Mean) 1.332 % 10.6019/CHEMBL5209801
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor %Inhib (Mean) -39.12 % 10.6019/CHEMBL5209801
Homo sapiens Beta-2 adrenergic receptor %Inhib (Mean) -23.1 % 10.6019/CHEMBL5209801
Homo sapiens Beta-2 adrenergic receptor %Inhib (Mean) 0.53 % 10.6019/CHEMBL5209801
Homo sapiens Beta-2 adrenergic receptor %Inhib (Mean) 18.34 % 10.6019/CHEMBL5209801
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor %Max (Mean) -1.9 % 10.6019/CHEMBL5209801
Homo sapiens Beta-3 adrenergic receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Bile acid transporter IC50 30000.0 nM 10.1016/j.bmcl.2019.126623
Homo sapiens Bile acid transporter Ki 11900.0 nM 10.1021/acs.jmedchem.2c01097
Homo sapiens Bile salt export pump IC50 7300.0 nM 10.1021/acs.jmedchem.0c00524
Homo sapiens Bile salt export pump IC50 7310.0 nM 10.1002/hep.27206
Homo sapiens Bile salt export pump IC50 7310.0 nM 10.1093/toxsci/kft176
Homo sapiens Bradykinin B1 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Bromodomain-containing protein 4 Delta TM -3.71 C None
Homo sapiens C5a anaphylatoxin chemotactic receptor %Inhib (Mean) -79.34 % 10.6019/CHEMBL5209801
Homo sapiens C5a anaphylatoxin chemotactic receptor %Inhib (Mean) -6.02 % 10.6019/CHEMBL5209801
Homo sapiens C5a anaphylatoxin chemotactic receptor %Inhib (Mean) -5.76 % 10.6019/CHEMBL5209801
Homo sapiens C5a anaphylatoxin chemotactic receptor %Inhib (Mean) -2.67 % 10.6019/CHEMBL5209801
Homo sapiens C5a anaphylatoxin chemotactic receptor %Max (Mean) -3.984 % 10.6019/CHEMBL5209801
Homo sapiens Caco-2 Activity 100.0 nm/s 10.1021/jm049548x
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens Canalicular multispecific organic anion transporter 1 Activity nan None 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 21100.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Casein kinase I delta Delta TM 0.34 C None
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens Cholecystokinin A receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Cholecystokinin B receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Corticotropin releasing factor receptor 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens C-X3-C chemokine receptor 1 %Inhib (Mean) -55.24 % 10.6019/CHEMBL5209801
Homo sapiens C-X3-C chemokine receptor 1 %Inhib (Mean) -26.16 % 10.6019/CHEMBL5209801
Homo sapiens C-X3-C chemokine receptor 1 %Inhib (Mean) -23.57 % 10.6019/CHEMBL5209801
Homo sapiens C-X3-C chemokine receptor 1 %Inhib (Mean) -13.1 % 10.6019/CHEMBL5209801
Homo sapiens C-X3-C chemokine receptor 1 %Max (Mean) 1.405 % 10.6019/CHEMBL5209801
Homo sapiens Cyclin-dependent kinase 2 Delta TM 0.15 C None
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 IC50 nan None None
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 IC50 nan None None
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C9 Activity nan None 10.1124/dmd.110.037259
Homo sapiens Cytochrome P450 2C9 IC50 nan None None
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2D6 IC50 nan None None
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Potency 15848.9 nM None
Homo sapiens Delta opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 100.0 nM None
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine D5 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Endothelin receptor ET-A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki 0.0001 nM 10.1021/jm020138n
Homo sapiens Endothelin receptor ET-A Ki 10000.0 nM 10.1021/jm058225d
Homo sapiens Endothelin receptor ET-A Ki 10000.0 nM 10.1021/jm300682j
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Endothelin receptor ET-B AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Equilibrative nucleoside transporter 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Fibroblast Control DMSO Fragmented Nuclei % 13.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Fragmented Nuclei % 14.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Fragmented Nuclei % 15.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Fragmented Nuclei % 18.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Fragmented Nuclei % 21.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Fragmented Nuclei % 22.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Fragmented Nuclei % 24.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Fragmented Nuclei % 28.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Healthy Nuclei (%) 53.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Healthy Nuclei (%) 54.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Healthy Nuclei (%) 56.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Healthy Nuclei (%) 62.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Healthy Nuclei (%) 67.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Healthy Nuclei (%) 68.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Healthy Nuclei (%) 69.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Membrane Permeable-Phenotype Cells (%) 0.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Membrane Permeable-Phenotype Cells (%) 4.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Membrane Permeable-Phenotype Cells (%) 5.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Membrane Permeable-Phenotype Cells (%) 6.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Membrane Permeable-Phenotype Cells (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitochondria Different-Phenotype Cells (%) 3.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitochondria Different-Phenotype Cells (%) 4.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitochondria Different-Phenotype Cells (%) 5.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitochondria Different-Phenotype Cells (%) 6.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitochondria Different-Phenotype Cells (%) 9.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitotic Cells (%) 42.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitotic Cells (%) 46.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitotic Cells (%) 47.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitotic Cells (%) 51.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitotic Cells (%) 55.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitotic Cells (%) 60.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitotic Cells (%) 61.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Mitotic Cells (%) 66.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Pyknosed Nuclei (%) 13.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Pyknosed Nuclei (%) 15.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Pyknosed Nuclei (%) 16.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Pyknosed Nuclei (%) 18.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Pyknosed Nuclei (%) 19.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Pyknosed Nuclei (%) 21.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Pyknosed Nuclei (%) 23.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Pyknosed Nuclei (%) 24.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Total Cells 14985.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Total Cells 15057.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Total Cells 15078.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Total Cells 15171.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Total Cells 16285.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Total Cells 16485.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Total Cells 16657.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Total Cells 17835.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Tubulin Phenotype Different Cells (%) 23.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Tubulin Phenotype Different Cells (%) 24.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Tubulin Phenotype Different Cells (%) 25.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Tubulin Phenotype Different Cells (%) 35.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Tubulin Phenotype Different Cells (%) 40.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Control DMSO Tubulin Phenotype Different Cells (%) 41.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Growth Rate -0.32 None 10.6019/CHEMBL5058564
Homo sapiens Fibroblast Growth Rate -0.26 None 10.6019/CHEMBL5058564
Homo sapiens Fibroblast Growth Rate 0.01 None 10.6019/CHEMBL5058564
Homo sapiens Fibroblast Growth Rate 0.09 None 10.6019/CHEMBL5058564
Homo sapiens Fibroblast Growth Rate 0.38 None 10.6019/CHEMBL5058564
Homo sapiens Fibroblast Growth Rate 0.58 None 10.6019/CHEMBL5058564
Homo sapiens Fibroblast Growth Rate 0.66 None 10.6019/CHEMBL5058564
Homo sapiens Fibroblast Growth Rate 0.98 None 10.6019/CHEMBL5058564
Homo sapiens Fibroblast Population Apoptotic (%) 24.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Apoptotic (%) 31.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Apoptotic (%) 36.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Apoptotic (%) 37.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Apoptotic (%) 38.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Apoptotic (%) 40.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Apoptotic (%) 45.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Apoptotic (%) 47.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Apoptotic (%) 55.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Apoptotic (%) 56.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Apoptotic (%) 60.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Apoptotic (%) 61.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Fragmented Nuclei (%) 9.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Fragmented Nuclei (%) 11.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Fragmented Nuclei (%) 14.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Fragmented Nuclei (%) 19.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Fragmented Nuclei (%) 21.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Fragmented Nuclei (%) 24.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Fragmented Nuclei (%) 25.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Fragmented Nuclei (%) 31.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Fragmented Nuclei (%) 32.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Fragmented Nuclei (%) 33.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Fragmented Nuclei (%) 36.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Fragmented Nuclei (%) 37.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 47.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 48.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 49.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 55.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 56.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 57.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 58.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 62.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 66.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 67.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 69.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 72.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Healthy Nuclei (%) 74.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Hoechst High Intensity Objects (%) 0.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Hoechst High Intensity Objects (%) 1.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Hoechst High Intensity Objects (%) 2.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Hoechst High Intensity Objects (%) 3.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Hoechst High Intensity Objects (%) 5.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Hoechst High Intensity Objects (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Membrane Permeable-Phenotype (%) 0.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Membrane Permeable-Phenotype (%) 1.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Membrane Permeable-Phenotype (%) 2.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Membrane Permeable-Phenotype (%) 3.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Membrane Permeable-Phenotype (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Membrane Permeable-Phenotype (%) 8.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Membrane Permeable-Phenotype (%) 12.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitochondria Different-Phenotype (%) 0.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitochondria Different-Phenotype (%) 1.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitochondria Different-Phenotype (%) 2.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitochondria Different-Phenotype (%) 3.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitochondria Different-Phenotype (%) 4.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitochondria Different-Phenotype (%) 5.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitochondria Different-Phenotype (%) 6.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitochondria Different-Phenotype (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitotic Cells (%) 38.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitotic Cells (%) 40.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitotic Cells (%) 44.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitotic Cells (%) 52.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitotic Cells (%) 54.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitotic Cells (%) 55.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitotic Cells (%) 59.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitotic Cells (%) 61.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitotic Cells (%) 62.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitotic Cells (%) 63.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitotic Cells (%) 68.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Mitotic Cells (%) 76.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Normal (%) 92.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Normal (%) 94.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Normal (%) 96.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Normal (%) 97.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Normal (%) 98.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Normal (%) 99.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Pyknosed Nuclei (%) 8.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Pyknosed Nuclei (%) 10.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Pyknosed Nuclei (%) 13.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Pyknosed Nuclei (%) 15.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Pyknosed Nuclei (%) 16.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Pyknosed Nuclei (%) 17.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Pyknosed Nuclei (%) 18.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Pyknosed Nuclei (%) 19.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Pyknosed Nuclei (%) 20.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 16.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 18.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 22.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 28.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 31.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 37.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 38.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 39.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 40.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 41.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 42.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 43.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 53.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 58.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Population Tubulin-Different-Phenotype (%) 60.0 % 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 117.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 125.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 129.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 141.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 148.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 150.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 151.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 155.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 159.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 170.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 173.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 176.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 178.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 183.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 187.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast Total Cell Count 197.0 None 10.6019/CHEMBL5058577
Homo sapiens Fibroblast growth factor receptor 3 Delta TM 0.21 C None
Homo sapiens GABA-B receptor 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Gastric inhibitory polypeptide receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Ghrelin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucagon-like peptide 1 receptor %Inhib (Mean) -47.11 % 10.6019/CHEMBL5209801
Homo sapiens Glucagon-like peptide 1 receptor %Inhib (Mean) -22.44 % 10.6019/CHEMBL5209801
Homo sapiens Glucagon-like peptide 1 receptor %Inhib (Mean) -19.84 % 10.6019/CHEMBL5209801
Homo sapiens Glucagon-like peptide 1 receptor %Inhib (Mean) -19.31 % 10.6019/CHEMBL5209801
Homo sapiens Glucagon-like peptide 1 receptor %Max (Mean) 1.55 % 10.6019/CHEMBL5209801
Homo sapiens Glucagon receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Glucose-dependent insulinotropic receptor %Inhib (Mean) -19.64 % 10.6019/CHEMBL5209801
Homo sapiens Glucose-dependent insulinotropic receptor %Inhib (Mean) -16.33 % 10.6019/CHEMBL5209801
Homo sapiens Glucose-dependent insulinotropic receptor %Inhib (Mean) -16.13 % 10.6019/CHEMBL5209801
Homo sapiens Glucose-dependent insulinotropic receptor %Inhib (Mean) -12.31 % 10.6019/CHEMBL5209801
Homo sapiens Glucose-dependent insulinotropic receptor %Max (Mean) 1.074 % 10.6019/CHEMBL5209801
Homo sapiens Glycogen synthase kinase-3 beta Delta TM -0.07 C None
Homo sapiens G-protein coupled receptor 120 %Inhib (Mean) -113.5 % 10.6019/CHEMBL5209801
Homo sapiens G-protein coupled receptor 120 %Inhib (Mean) -80.29 % 10.6019/CHEMBL5209801
Homo sapiens G-protein coupled receptor 120 %Inhib (Mean) -21.87 % 10.6019/CHEMBL5209801
Homo sapiens G-protein coupled receptor 120 %Inhib (Mean) -21.55 % 10.6019/CHEMBL5209801
Homo sapiens G-protein coupled receptor 120 %Max (Mean) -0.6 % 10.6019/CHEMBL5209801
Homo sapiens G-protein coupled receptor 35 %Inhib (Mean) -25.39 % 10.6019/CHEMBL5209801
Homo sapiens G-protein coupled receptor 35 %Max (Mean) 16.13 % 10.6019/CHEMBL5209801
Homo sapiens HASMC IC50 320.0 nM 10.1021/jm9504722
Homo sapiens HCT-116 Activity 88.0 % 10.1021/acsmedchemlett.1c00240
Homo sapiens HEK-293T Control DMSO Fragmented Nuclei % 5.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Fragmented Nuclei % 6.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Fragmented Nuclei % 7.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Fragmented Nuclei % 9.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Fragmented Nuclei % 13.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Fragmented Nuclei % 15.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Healthy Nuclei (%) 46.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Healthy Nuclei (%) 61.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Healthy Nuclei (%) 79.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Healthy Nuclei (%) 80.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Healthy Nuclei (%) 81.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Healthy Nuclei (%) 82.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Membrane Permeable-Phenotype Cells (%) 0.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Membrane Permeable-Phenotype Cells (%) 1.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitochondria Different-Phenotype Cells (%) 13.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitochondria Different-Phenotype Cells (%) 18.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitochondria Different-Phenotype Cells (%) 24.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitochondria Different-Phenotype Cells (%) 36.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitochondria Different-Phenotype Cells (%) 41.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitochondria Different-Phenotype Cells (%) 59.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitochondria Different-Phenotype Cells (%) 65.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitochondria Different-Phenotype Cells (%) 83.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitotic Cells (%) 40.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitotic Cells (%) 51.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitotic Cells (%) 55.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitotic Cells (%) 63.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitotic Cells (%) 66.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitotic Cells (%) 72.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitotic Cells (%) 75.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Mitotic Cells (%) 77.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Pyknosed Nuclei (%) 5.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Pyknosed Nuclei (%) 6.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Pyknosed Nuclei (%) 9.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Pyknosed Nuclei (%) 10.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Pyknosed Nuclei (%) 12.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Pyknosed Nuclei (%) 32.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Pyknosed Nuclei (%) 45.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Total Cells 22878.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Total Cells 29842.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Total Cells 35035.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Total Cells 45150.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Total Cells 45535.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Total Cells 60692.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Total Cells 68271.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Total Cells 101135.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Tubulin Phenotype Different Cells (%) 9.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Tubulin Phenotype Different Cells (%) 12.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Tubulin Phenotype Different Cells (%) 14.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Tubulin Phenotype Different Cells (%) 18.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Tubulin Phenotype Different Cells (%) 20.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Control DMSO Tubulin Phenotype Different Cells (%) 22.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Growth Rate 0.31 None 10.6019/CHEMBL5058564
Homo sapiens HEK-293T Growth Rate 0.68 None 10.6019/CHEMBL5058564
Homo sapiens HEK-293T Growth Rate 0.8 None 10.6019/CHEMBL5058564
Homo sapiens HEK-293T Growth Rate 0.86 None 10.6019/CHEMBL5058564
Homo sapiens HEK-293T Population Apoptotic (%) 23.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 24.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 25.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 27.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 28.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 29.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 31.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 34.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 38.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 39.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 41.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 46.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 50.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 56.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Apoptotic (%) 60.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Fragmented Nuclei (%) 3.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Fragmented Nuclei (%) 4.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Fragmented Nuclei (%) 6.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Fragmented Nuclei (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Fragmented Nuclei (%) 8.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Fragmented Nuclei (%) 9.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Fragmented Nuclei (%) 11.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Fragmented Nuclei (%) 12.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Fragmented Nuclei (%) 15.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Healthy Nuclei (%) 23.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Healthy Nuclei (%) 47.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Healthy Nuclei (%) 65.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Healthy Nuclei (%) 66.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Healthy Nuclei (%) 70.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Healthy Nuclei (%) 75.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Healthy Nuclei (%) 77.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Healthy Nuclei (%) 78.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Healthy Nuclei (%) 79.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Healthy Nuclei (%) 80.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Healthy Nuclei (%) 81.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Healthy Nuclei (%) 84.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Hoechst High Intensity Objects (%) 1.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Hoechst High Intensity Objects (%) 2.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Hoechst High Intensity Objects (%) 3.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Hoechst High Intensity Objects (%) 4.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Hoechst High Intensity Objects (%) 5.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Hoechst High Intensity Objects (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Hoechst High Intensity Objects (%) 9.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Hoechst High Intensity Objects (%) 10.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Hoechst High Intensity Objects (%) 13.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Membrane Permeable-Phenotype (%) 0.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Membrane Permeable-Phenotype (%) 1.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Membrane Permeable-Phenotype (%) 2.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 19.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 21.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 24.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 26.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 34.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 37.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 45.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 46.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 49.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 55.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 63.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 64.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 66.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 79.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitochondria Different-Phenotype (%) 83.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 40.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 43.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 50.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 53.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 58.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 60.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 61.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 65.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 68.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 70.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 71.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 72.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 75.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Mitotic Cells (%) 76.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Normal (%) 86.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Normal (%) 89.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Normal (%) 90.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Normal (%) 91.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Normal (%) 92.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Normal (%) 94.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Normal (%) 95.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Normal (%) 96.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Normal (%) 97.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Normal (%) 98.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Pyknosed Nuclei (%) 6.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Pyknosed Nuclei (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Pyknosed Nuclei (%) 9.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Pyknosed Nuclei (%) 10.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Pyknosed Nuclei (%) 11.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Pyknosed Nuclei (%) 12.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Pyknosed Nuclei (%) 15.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Pyknosed Nuclei (%) 22.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Pyknosed Nuclei (%) 29.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Pyknosed Nuclei (%) 43.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Pyknosed Nuclei (%) 67.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 8.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 11.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 13.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 14.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 15.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 16.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 17.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 20.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 21.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 22.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 32.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 33.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Population Tubulin-Different-Phenotype (%) 50.0 % 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 166.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 219.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 242.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 245.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 287.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 351.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 352.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 353.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 434.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 456.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 473.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 500.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 625.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 684.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 705.0 None 10.6019/CHEMBL5058577
Homo sapiens HEK-293T Total Cell Count 958.0 None 10.6019/CHEMBL5058577
Homo sapiens Hepatocyte CL 3.85 mL.min-1.kg-1 10.1016/j.ejmech.2008.07.027
Homo sapiens Hepatocyte logCL 0.5855 None 10.1016/j.ejmech.2008.07.027
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG IC50 194984.46 nM 10.1016/j.ejmech.2010.11.042
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -8.81 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -1.24 % 10.6019/CHEMBL4808148
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homo sapiens Activity nan None 10.1002/hep.27206
Homo sapiens Homo sapiens AUC 22656.91 ng.hr.mL-1 10.1093/toxsci/kft176
Homo sapiens Homo sapiens CL 2.12 mL.min-1.kg-1 None
Homo sapiens Homo sapiens Cmax 3033.56 nM None
Homo sapiens Homo sapiens Cmax 3505.0 nM 10.1002/hep.27206
Homo sapiens Homo sapiens Css 2.203 uM 10.1093/toxsci/kft176
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 5.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens Excretion 2.2 % None
Homo sapiens Homo sapiens F 60.0 % None
Homo sapiens Homo sapiens F 70.0 % 10.1016/j.bmc.2007.08.060
Homo sapiens Homo sapiens T1/2 13.0 hr None
Homo sapiens Homo sapiens Tmax 1.2 hr None
Homo sapiens Homo sapiens Vd 2.9 L.kg-1 None
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Leukotriene B4 receptor 1 Activity nan None 10.1021/acsmedchemlett.1c00240
Homo sapiens Leukotriene B4 receptor 2 EC50 410.0 nM 10.1021/acsmedchemlett.1c00240
Homo sapiens Leukotriene B4 receptor 2 Efficacy 69.0 % 10.1021/acsmedchemlett.1c00240
Homo sapiens Lipoxin A4 receptor %Inhib (Mean) -62.94 % 10.6019/CHEMBL5209801
Homo sapiens Lipoxin A4 receptor %Inhib (Mean) -20.77 % 10.6019/CHEMBL5209801
Homo sapiens Lipoxin A4 receptor %Inhib (Mean) -11.48 % 10.6019/CHEMBL5209801
Homo sapiens Lipoxin A4 receptor %Inhib (Mean) -2.54 % 10.6019/CHEMBL5209801
Homo sapiens Lipoxin A4 receptor %Max (Mean) -2.87 % 10.6019/CHEMBL5209801
Homo sapiens Lysosomal alpha-glucosidase Potency 446.7 nM None
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK2 Delta TM 0.2 C None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase ERK2 Potency 19952.6 nM None
Homo sapiens MAP kinase p38 alpha IC50 nan None None
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens Melanocortin receptor 3 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens microRNA 21 Potency 6561.4 nM None
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug and toxin extrusion protein 1 IC50 500000.0 nM 10.1021/jm301302s
Homo sapiens Multidrug and toxin extrusion protein 1 Inhibition 15.0 % 10.1021/jm301302s
Homo sapiens Multidrug resistance-associated protein 4 IC50 83200.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Neurokinin 1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotensin receptor 1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens Peregrin Delta TM -3.84 C None
Homo sapiens Peroxisome proliferator-activated receptor gamma Alpha max 8.1 % 10.1016/j.ejmech.2020.112258
Homo sapiens Peroxisome proliferator-activated receptor gamma EC50 nan None 10.1016/j.ejmech.2020.112258
Homo sapiens Phosphodiesterase 3A AC50 4098.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 5A IC50 nan None None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Phosphodiesterase 6A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Plasma PPB 98.0 % 10.1016/j.bmcl.2011.04.133
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Prelamin-A/C Potency 398.1 nM None
Homo sapiens Progesterone receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Serine/threonine-protein kinase Aurora-A Delta TM 0.12 C None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 35000.2 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 5a (5-HT5a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin 7 (5-HT7) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens Solute carrier organic anion transporter family member 1B1 Inhibition 76.05 % 10.1124/mol.112.084152
Homo sapiens Solute carrier organic anion transporter family member 1B3 Inhibition 47.18 % 10.1124/mol.112.084152
Homo sapiens Sphingosine 1-phosphate receptor Edg-1 %Inhib (Mean) -15.3 % 10.6019/CHEMBL5209801
Homo sapiens Sphingosine 1-phosphate receptor Edg-1 %Inhib (Mean) -8.92 % 10.6019/CHEMBL5209801
Homo sapiens Sphingosine 1-phosphate receptor Edg-1 %Inhib (Mean) -8.13 % 10.6019/CHEMBL5209801
Homo sapiens Sphingosine 1-phosphate receptor Edg-1 %Inhib (Mean) -1.53 % 10.6019/CHEMBL5209801
Homo sapiens Sphingosine 1-phosphate receptor Edg-1 %Max (Mean) -0.5207 % 10.6019/CHEMBL5209801
Homo sapiens Thromboxane A2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Thromboxane A2 receptor Inhibition 50.0 % 10.1021/acs.jmedchem.0c00262
Homo sapiens Thromboxane A2 receptor MEC 0.5 uM 10.1021/acs.jmedchem.0c00262
Homo sapiens Thromboxane-A synthase IC50 nan None None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Transcription intermediary factor 1-alpha Delta TM -3.66 C None
Homo sapiens Type-1 angiotensin II receptor AC50 0.8 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor AC50 0.9 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor AC50 1.7 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor Affinity 1.3 nM 10.1021/jm049024x
Homo sapiens Type-1 angiotensin II receptor AT1 affinity 1.3 nM l-1 10.1021/jm0204237
Homo sapiens Type-1 angiotensin II receptor Emax 2.5 hr 10.1021/jm049024x
Homo sapiens Type-1 angiotensin II receptor IC50 6.0 nM 10.1021/acsmedchemlett.1c00240
Homo sapiens Type-1 angiotensin II receptor IC50 20.8 nM 10.1016/j.bmc.2010.10.043
Homo sapiens Type-1 angiotensin II receptor %Inhib (Mean) 90.39 % 10.6019/CHEMBL5209801
Homo sapiens Type-1 angiotensin II receptor %Inhib (Mean) 96.87 % 10.6019/CHEMBL5209801
Homo sapiens Type-1 angiotensin II receptor %Inhib (Mean) 100.24 % 10.6019/CHEMBL5209801
Homo sapiens Type-1 angiotensin II receptor %Inhib (Mean) 103.02 % 10.6019/CHEMBL5209801
Homo sapiens Type-1 angiotensin II receptor K 0.039 /min 10.1016/j.bmcl.2017.06.051
Homo sapiens Type-1 angiotensin II receptor K 0.04 /min 10.1016/j.bmcl.2017.06.051
Homo sapiens Type-1 angiotensin II receptor K 0.058 /min 10.1016/j.bmcl.2017.06.051
Homo sapiens Type-1 angiotensin II receptor K 0.101 /min 10.1016/j.bmcl.2017.06.051
Homo sapiens Type-1 angiotensin II receptor K 0.104 /min 10.1016/j.bmcl.2017.06.051
Homo sapiens Type-1 angiotensin II receptor K 0.128 /min 10.1016/j.bmcl.2017.06.051
Homo sapiens Type-1 angiotensin II receptor Ki 0.8 nM 10.1021/jm058225d
Homo sapiens Type-1 angiotensin II receptor Ki 0.8 nM 10.1021/jm300682j
Homo sapiens Type-1 angiotensin II receptor Ki 1.1 nM 10.1021/jm020138n
Homo sapiens Type-1 angiotensin II receptor Ki 2.0 nM 10.1021/jm010457z
Homo sapiens Type-1 angiotensin II receptor Ki 2.0 nM 10.1021/jm9904147
Homo sapiens Type-1 angiotensin II receptor %Max (Mean) 0.5895 % 10.6019/CHEMBL5209801
Homo sapiens Type-1 angiotensin II receptor pKa 4.7 None 10.1021/jm049024x
Homo sapiens Type-1 angiotensin II receptor Ratio IC50 10.0 None 10.1016/j.bmc.2010.10.043
Homo sapiens Type-1 angiotensin II receptor TIME 0.15 hr 10.1016/j.bmcl.2017.06.051
Homo sapiens Type-1 angiotensin II receptor TIME 0.1667 hr 10.1016/j.bmcl.2017.06.051
Homo sapiens Type-1 angiotensin II receptor TIME 0.2833 hr 10.1016/j.bmcl.2017.06.051
Homo sapiens Type-1 angiotensin II receptor TIME 0.4167 hr 10.1016/j.bmcl.2017.06.051
Homo sapiens Type-1 angiotensin II receptor TIME 0.4333 hr 10.1016/j.bmcl.2017.06.051
Homo sapiens Tyrosine-protein kinase ABL Delta TM 0.06 C None
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens U2OS Control DMSO Fragmented Nuclei % 14.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Fragmented Nuclei % 15.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Fragmented Nuclei % 16.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Fragmented Nuclei % 17.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Fragmented Nuclei % 19.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Fragmented Nuclei % 23.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Fragmented Nuclei % 26.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Fragmented Nuclei % 33.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Healthy Nuclei (%) 56.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Healthy Nuclei (%) 65.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Healthy Nuclei (%) 68.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Healthy Nuclei (%) 71.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Healthy Nuclei (%) 74.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Healthy Nuclei (%) 76.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Membrane Permeable-Phenotype Cells (%) 5.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Membrane Permeable-Phenotype Cells (%) 6.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Membrane Permeable-Phenotype Cells (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Mitochondria Different-Phenotype Cells (%) 2.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Mitochondria Different-Phenotype Cells (%) 3.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Mitochondria Different-Phenotype Cells (%) 4.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Mitochondria Different-Phenotype Cells (%) 6.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Mitotic Cells (%) 8.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Mitotic Cells (%) 9.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Mitotic Cells (%) 12.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Mitotic Cells (%) 14.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Mitotic Cells (%) 16.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Mitotic Cells (%) 18.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Mitotic Cells (%) 28.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Pyknosed Nuclei (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Pyknosed Nuclei (%) 8.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Pyknosed Nuclei (%) 9.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Pyknosed Nuclei (%) 10.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Total Cells 8571.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Total Cells 11828.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Total Cells 14221.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Total Cells 20657.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Total Cells 20807.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Total Cells 26450.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Total Cells 31171.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Total Cells 44507.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Tubulin Phenotype Different Cells (%) 3.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Tubulin Phenotype Different Cells (%) 4.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Control DMSO Tubulin Phenotype Different Cells (%) 5.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Growth Rate -1.0 None 10.6019/CHEMBL5058564
Homo sapiens U2OS Growth Rate 0.3 None 10.6019/CHEMBL5058564
Homo sapiens U2OS Growth Rate 0.72 None 10.6019/CHEMBL5058564
Homo sapiens U2OS Growth Rate 0.87 None 10.6019/CHEMBL5058564
Homo sapiens U2OS Growth Rate 0.92 None 10.6019/CHEMBL5058564
Homo sapiens U2OS Growth Rate 0.94 None 10.6019/CHEMBL5058564
Homo sapiens U2OS Growth Rate 0.95 None 10.6019/CHEMBL5058564
Homo sapiens U2OS Growth Rate 0.97 None 10.6019/CHEMBL5058564
Homo sapiens U2OS Population Apoptotic (%) 55.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Apoptotic (%) 57.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Apoptotic (%) 66.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Apoptotic (%) 70.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Apoptotic (%) 71.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Apoptotic (%) 77.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Apoptotic (%) 83.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Apoptotic (%) 89.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Apoptotic (%) 91.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Apoptotic (%) 94.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Apoptotic (%) 96.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Apoptotic (%) 97.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Apoptotic (%) 100.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Fragmented Nuclei (%) 6.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Fragmented Nuclei (%) 9.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Fragmented Nuclei (%) 12.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Fragmented Nuclei (%) 14.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Fragmented Nuclei (%) 16.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Fragmented Nuclei (%) 18.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Fragmented Nuclei (%) 22.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Fragmented Nuclei (%) 23.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Fragmented Nuclei (%) 25.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Fragmented Nuclei (%) 26.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Fragmented Nuclei (%) 30.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Fragmented Nuclei (%) 33.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 59.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 65.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 66.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 68.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 69.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 71.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 72.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 73.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 74.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 75.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 76.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 81.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Healthy Nuclei (%) 82.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Hoechst High Intensity Objects (%) 0.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Hoechst High Intensity Objects (%) 2.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Hoechst High Intensity Objects (%) 3.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Hoechst High Intensity Objects (%) 4.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Membrane Permeable-Phenotype (%) 4.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Membrane Permeable-Phenotype (%) 5.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Membrane Permeable-Phenotype (%) 6.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Membrane Permeable-Phenotype (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Membrane Permeable-Phenotype (%) 8.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Membrane Permeable-Phenotype (%) 9.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Membrane Permeable-Phenotype (%) 11.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitochondria Different-Phenotype (%) 0.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitochondria Different-Phenotype (%) 1.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitochondria Different-Phenotype (%) 2.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitochondria Different-Phenotype (%) 3.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitochondria Different-Phenotype (%) 5.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitochondria Different-Phenotype (%) 6.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitochondria Different-Phenotype (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 0.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 2.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 4.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 5.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 8.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 10.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 16.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 22.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 28.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 29.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 33.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 42.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Mitotic Cells (%) 44.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Normal (%) 95.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Normal (%) 96.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Normal (%) 97.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Normal (%) 99.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Normal (%) 100.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Pyknosed Nuclei (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Pyknosed Nuclei (%) 8.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Pyknosed Nuclei (%) 9.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Pyknosed Nuclei (%) 10.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Pyknosed Nuclei (%) 11.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Tubulin-Different-Phenotype (%) 0.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Tubulin-Different-Phenotype (%) 1.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Tubulin-Different-Phenotype (%) 2.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Tubulin-Different-Phenotype (%) 3.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Tubulin-Different-Phenotype (%) 4.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Tubulin-Different-Phenotype (%) 7.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Population Tubulin-Different-Phenotype (%) 8.0 % 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 77.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 80.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 100.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 124.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 135.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 142.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 175.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 185.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 198.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 200.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 233.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 241.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 254.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 301.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 357.0 None 10.6019/CHEMBL5058577
Homo sapiens U2OS Total Cell Count 419.0 None 10.6019/CHEMBL5058577
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vasopressin V2 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 7.4 % 10.6019/CHEMBL4513141
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Oryctolagus cuniculus Oryctolagus cuniculus IC50 4.0 nM 10.1016/S0960-894X(01)81120-3
Oryctolagus cuniculus Oryctolagus cuniculus IC50 4.0 nM 10.1021/jm00074a018
Oryctolagus cuniculus Oryctolagus cuniculus IC50 4.0 nM 10.1021/jm9504722
Photinus pyralis Luciferin 4-monooxygenase Potency 19011.5 nM None
Plasmodium falciparum Plasmodium falciparum Potency 7568.6 nM None
Plasmodium falciparum Plasmodium falciparum Potency 13459.1 nM None
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 1.45 % 10.6019/CHEMBL4513141
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Angiotensin II receptor IC50 1.3 nM 10.1016/S0960-894X(00)80286-3
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 Activity 13500.0 AUC units 10.1021/jm049548x
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 IC50 1.3 nM 10.1016/S0960-894X(01)81120-3
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 IC50 1.3 nM 10.1021/jm9504722
Rattus norvegicus Cyclooxygenase-1 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Endothelin receptor ET-A Activity nan None 10.1021/jm049548x
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Liver IC50 nan None 10.1002/hep.27206
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Rattus norvegicus Activity 20.0 mmHg 10.1039/C5MD00169B
Rattus norvegicus Rattus norvegicus Activity nan None 10.1016/j.bmc.2012.02.003
Rattus norvegicus Rattus norvegicus Activity nan None 10.1021/jm020138n
Rattus norvegicus Rattus norvegicus Activity nan None 10.1039/C4MD00499J
Rattus norvegicus Rattus norvegicus Activity nan None 10.1039/C5MD00169B
Rattus norvegicus Rattus norvegicus ALB 42000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 42300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 43300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 44700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 46500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALB 46700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 278.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 299.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 300.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 305.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 316.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALP 366.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 42.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 44.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 44.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 46.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus ALT 49.17 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AOC 11900.0 None 10.1016/s0960-894x(03)00018-0
Rattus norvegicus Rattus norvegicus AST 74.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 75.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 75.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 80.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 86.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus AST 87.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 0.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BASOLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 0.833 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BILI 1.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BP 84.0 % 10.1016/s0960-894x(03)00018-0
Rattus norvegicus Rattus norvegicus BUN 155.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 170.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 176.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 183.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus BUN 186.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 98.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 99.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 101.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 102.83 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHLORIDE 103.33 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 693.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 706.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 730.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 740.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 745.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CHOL 783.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 216.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 219.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 271.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 320.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 600.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CK 891.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 20000000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 21330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 21500000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24170000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 24330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CO2 28330000.0 nM 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 2.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus CREAT 3.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus Delta MAP 17.0 mmHg 10.1016/S0960-894X(01)81139-2
Rattus norvegicus Rattus norvegicus Delta MAP 18.0 mmHg 10.1016/S0960-894X(01)81139-2
Rattus norvegicus Rattus norvegicus Delta MAP 20.0 mmHg 10.1016/S0960-894X(01)81139-2
Rattus norvegicus Rattus norvegicus Delta MAP 22.0 mmHg 10.1016/S0960-894X(01)81139-2
Rattus norvegicus Rattus norvegicus Delta MAP 45.0 mmHg 10.1016/S0960-894X(01)81139-2
Rattus norvegicus Rattus norvegicus ED30 0.16 mg kg-1 10.1016/S0960-894X(01)80526-6
Rattus norvegicus Rattus norvegicus ED50 0.3 umol.kg-1 10.1021/jm020138n
Rattus norvegicus Rattus norvegicus ED50 16.0 umol.kg-1 10.1021/jm020138n
Rattus norvegicus Rattus norvegicus EOSLE 0.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 0.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus EOSLE 1.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1333.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1360.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1396.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1408.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1440.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus GLUC 1620.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 42.37 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 43.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 43.12 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 43.13 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 43.7 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HCT 44.8 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 141800.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 142300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 146000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 146300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 147300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus HGB 149000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 161.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 197.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 210.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 289.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 300.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LDH 345.5 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.67 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 8.83 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.0 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LIPASE 9.33 U.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 72.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 75.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 75.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 79.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 80.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus LYMLE 81.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 19.6 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.17 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.25 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.3 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.33 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCH 20.35 pg 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 329500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 332000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 335700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 337300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCHC 339500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 59.0 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 59.7 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 59.8 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 59.93 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 60.47 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MCV 61.43 fL 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 1.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus MONOLE 2.83 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NE nan None 10.1021/jm020138n
Rattus norvegicus Rattus norvegicus NEUTLE 14.67 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 17.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 17.33 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 21.17 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 22.0 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus NEUTLE 24.5 % 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 78.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 86.5 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 90.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 91.2 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 93.7 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PHOS 95.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1028500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1093170.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1118000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1173330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1218500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PLAT 1226330.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.55 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.6 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.65 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.67 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 5.95 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus POTASSIUM 6.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 61700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 63000.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 63300.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 66700.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus PROT 67500.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 7010000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 7020000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 7200000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 7310000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus RBC 7590000.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 138.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 139.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 142.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 144.17 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 145.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus SODIUM 146.0 mEq.L-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus TIME 1.0 hr 10.1039/C5MD00169B
Rattus norvegicus Rattus norvegicus TIME 3.0 hr 10.1016/j.bmc.2012.02.003
Rattus norvegicus Rattus norvegicus URATE 9.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 9.8 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 10.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 11.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 12.3 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus URATE 13.0 ug.mL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9050.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9550.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 9630.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11100.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11400.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Rattus norvegicus WBC 11500.0 cells.uL-1 10.6019/CHEMBL3885881
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Type-1A angiotensin II receptor IC50 0.9 nM 10.1016/S0960-894X(01)80526-6
Rattus norvegicus Type-1B angiotensin II receptor IC50 1.3 nM 10.1016/S0960-894X(01)81139-2
Rattus norvegicus Type-1B angiotensin II receptor IC50 1.3 nM 10.1021/jm00074a018
Rattus norvegicus Type-1B angiotensin II receptor Ki 0.8 nM 10.1021/jm020138n
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Voltage-gated N-type calcium channel alpha-1B subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 9.227 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 13.92 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.2008 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -3.98 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.15 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.11 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index 0.3537 None 10.1101/2020.04.03.023846
Staphylococcus aureus Staphylococcus aureus Inhibition 6.34 % 10.6019/CHEMBL4513141
Trypanosoma cruzi Cruzipain Potency 39810.7 nM None
None ADMET Activity 300.0 mg 10.1021/acs.jmedchem.0c00524
None ADMET Biotransformation nan None 10.1038/s41586-019-1291-3
None ADMET CL 2.1 mL.min-1.kg-1 10.1021/acs.jmedchem.0c01033
None ADMET CL 2.3 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET CL 9.01 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 10.47 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 12.1 mL.min-1.kg-1 10.1021/acs.jmedchem.0c01033
None ADMET CL 17.78 mL.min-1.g-1 10.6019/CHEMBL3301361
None ADMET CL 39.0 mL.min-1.kg-1 10.1021/acs.jmedchem.0c01033
None ADMET CL_renal 0.02 ml s-1 10.1021/jm0204237
None ADMET CLtotal 5.1 ml s-1 10.1021/jm0204237
None ADMET F 70.0 % 10.1021/jm049024x
None ADMET F 90.0 % 10.1021/jm990412m
None ADMET Fu 0.000126 None 10.1021/acs.jmedchem.0c01033
None ADMET Fu 0.000155 None 10.1021/acs.jmedchem.0c01033
None ADMET Modification of adsorbed drug 20.0 % 10.1021/jm049024x
None ADMET MRT 6.8 hr 10.1124/dmd.108.020479
None ADMET Papp 8.6 10^-6 cm/s 10.1021/acs.jmedchem.0c01033
None ADMET pKa 4.7 None 10.1021/jm0204237
None ADMET PPB 98.54 % 10.6019/CHEMBL3301361
None ADMET Ratio 0.55 None 10.1021/acs.jmedchem.0c01033
None ADMET Ratio 0.603 None 10.1021/acs.jmedchem.0c01033
None ADMET T1/2 10.0 hr 10.1021/jm0204237
None ADMET T1/2 14.0 hr 10.1124/dmd.108.020479
None ADMET T1/2 21.0 hr 10.1021/jm049024x
None ADMET Vd 0.9 L.kg-1 10.1021/jm049024x
None ADMET Vdss 0.94 L.kg-1 10.1124/dmd.108.020479
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx1000865
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Hepatotoxicity Hepatotoxicity nan None 10.1124/dmd.110.035113
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 3.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None NON-PROTEIN TARGET Activity nan None 10.1016/j.ejmech.2016.07.023
None NON-PROTEIN TARGET Fu 0.1 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 2.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 4.3 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None No relevant target LogD 0.9 None 10.1016/j.bmcl.2011.04.133
None No relevant target LogD 1.3 None 10.1021/acs.jmedchem.0c01033
None No relevant target LogD 2.4 None 10.1016/j.bmcl.2011.04.133
None No relevant target LogD7.4 1.29 None 10.6019/CHEMBL3301361
None No relevant target pKa 3.5 None 10.1021/acs.jmedchem.0c01033
None No relevant target pKa 4.6 None 10.1021/acs.jmedchem.0c01033
None No relevant target pKa_A1 3.91 None 10.6019/CHEMBL3301361
None No relevant target pKa_B1 nan None 10.6019/CHEMBL3301361
None No relevant target Solubility 891300.0 nM 10.6019/CHEMBL3301361
None Unchecked Ac50 0.631 uM None
None Unchecked Ac50 2.818 uM None
None Unchecked Ac50 6.31 uM None
None Unchecked Ac50 39.81 uM None
None Unchecked AC50 631.0 nM None
None Unchecked AC50 2820.0 nM None
None Unchecked AC50 6309.6 nM None
None Unchecked AC50 39810.7 nM None
None Unchecked Activity 31.0 % 10.1016/j.ejmech.2020.112258
None Unchecked Activity 38.0 % 10.1021/acs.jmedchem.0c00262
None Unchecked Activity nan None 10.1016/j.ejmech.2020.112258
None Unchecked Hepatotoxicity (acute) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 2.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 0.58 nM 10.1016/j.bmc.2012.02.003
None Unchecked IC50 1.3 nM 10.1016/j.bmc.2010.10.043
None Unchecked IC50 1.46 nM 10.1016/j.ejmech.2016.07.023
None Unchecked IC50 3.11 nM 10.1016/j.bmc.2012.09.065
None Unchecked IC50 4.0 nM 10.1021/jm010457z
None Unchecked IC50 nan None None
None Unchecked Inhibition nan % 10.1016/j.bmc.2012.02.003
None Unchecked Inhibition nan % 10.1016/j.bmc.2012.09.065
None Unchecked Ki 0.41 nM 10.1016/j.bmc.2012.02.003
None Unchecked Ki 1.05 nM 10.1016/j.ejmech.2016.07.023
None Unchecked Ki 2.75 nM 10.1016/j.bmc.2012.09.065
None Unchecked Ki nan None None
None Unchecked Ratio 0.026 None 10.1093/toxsci/kft176
None Unchecked Ratio 0.104 None 10.1093/toxsci/kft176
None Unchecked Ratio 0.301 None 10.1093/toxsci/kft176

Metabolism Information