Eusynstyelamide D
AlkaPlorer ID: AK091814
Synonym: None
IUPAC Name: (2S,3R,4S)-N,1-bis(4-aminobutyl)-3-(6-bromo-1H-indol-3-yl)-4-[(6-bromo-1H-indol-3-yl)methyl]-2,4-dihydroxy-5-oxopyrrolidine-2-carboxamide
Structure
SMILES: NCCCCN=C(O)[C@@]1(O)[C@H](C2=CNC3=CC(Br)=CC=C23)[C@@](O)(CC2=CNC3=CC(Br)=CC=C23)C(=O)N1CCCCN
InChI: InChI=1S/C30H36Br2N6O4/c31-19-5-7-21-18(16-36-24(21)13-19)15-29(41)26(23-17-37-25-14-20(32)6-8-22(23)25)30(42,27(39)35-11-3-1-9-33)38(28(29)40)12-4-2-10-34/h5-8,13-14,16-17,26,36-37,41-42H,1-4,9-12,15,33-34H2,(H,35,39)/t26-,29+,30+/m1/s1
InChIKey: PIHIJDUVKHNVTR-POLDFPFKSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 704.4639999999997
TPSA？: 176.98000000000002
MolLogP？: 4.196700000000002
Number of H-Donors: 7
Number of H-Acceptors: 6
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Candida albicans | Candida albicans | MIC | 50.0 | ug.mL-1 | 10.1021/np100499c |
| Corynebacterium glutamicum | Corynebacterium glutamicum | MIC | 12.5 | ug.mL-1 | 10.1021/np100499c |
| Escherichia coli | Escherichia coli | MIC | 12.5 | ug.mL-1 | 10.1021/np100499c |
| Homo sapiens | A2058 | IC50 | 57000.0 | nM | 10.1021/np100499c |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | MIC | 25.0 | ug.mL-1 | 10.1021/np100499c |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 12.5 | ug.mL-1 | 10.1021/np100499c |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 20.0 | ug.mL-1 | 10.1021/np100499c |