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name Structure Reference Source Properties Activities Metabolism

Zonisamide

AlkaPlorer ID: AK091825

Synonym: None

IUPAC Name: 1,2-benzoxazol-3-ylmethanesulfonamide

Structure

SMILES: NS(=O)(=O)CC1=NOC2=CC=CC=C12

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InChI: InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)

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InChIKey: UBQNRHZMVUUOMG-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain

Properties Information

Molecule Weight: 212.23

TPSA？: 86.19000000000001

MolLogP？: 0.6163

Number of H-Donors: 1

Number of H-Acceptors: 4

RingCount: 2

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Inhibition 10.49 % 10.6019/CHEMBL4513141
Anopheles gambiae AGAP002992-PA Ki 263.0 nM 10.1016/j.bmc.2015.03.081
Astrosclera willeyana Astrosclerin-3 Ki 165.0 nM 10.1016/j.bmc.2012.01.007
Bos taurus Carbonic anhydrase 3 Ki 8510.0 nM 10.1016/j.ejmech.2011.12.022
Bos taurus Carbonic anhydrase IV NT nan None 10.1021/jm0109199
Brucella suis biovar 1 Carbonic anhydrase Kinact 1850.0 nM 10.1021/jm901855h
Candida albicans Candida albicans Inhibition 3.7 % 10.6019/CHEMBL4513141
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase FC 18.4 None 10.1021/jm1013242
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase Ki 940.0 nM 10.1021/jm1013242
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase Ki 942.0 nM 10.1016/j.bmc.2009.05.002
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Carbonic anhydrase Ki 942.0 nM 10.1021/jm300203r
Candida glabrata CBS 138 Carbonic anhydrase Ki 114.0 nM 10.1016/j.bmcl.2013.02.092
Canis lupus familiaris Brain Fu 0.428 None 10.1124/dmd.111.038778
Cryptococcus neoformans Cryptococcus neoformans Inhibition -5.53 % 10.6019/CHEMBL4513141
Cryptococcus neoformans var. grubii Carbonic anhydrase 2 Ki 970.0 nM 10.1021/jm1013242
Cryptococcus neoformans var. grubii Carbonic anhydrase 2 Ki 971.0 nM 10.1021/jm300203r
Danio rerio Amine oxidase [flavin-containing] Ki 30800.0 nM 10.1021/jm101359c
Escherichia coli Escherichia coli Inhibition 0.42 % 10.6019/CHEMBL4513141
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) Carbonic anhydrase 1 Ki 218.0 nM 10.1016/j.bmcl.2006.01.044
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) Carbonic anhydrase 1 Ki 231.0 nM 10.1021/jm0512600
Homo sapiens Adenosine A1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A2a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Adenosine A3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-1a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2a adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2b adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Alpha-2c adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Anandamide amidohydrolase Inhibition -17.9 % 10.1016/j.bmcl.2009.09.086
Homo sapiens Aquaporin-4 Activity nan None 10.1016/j.bmc.2008.06.005
Homo sapiens Aquaporin-4 permeability 0.0129 cm/s 10.1016/j.bmc.2008.06.005
Homo sapiens Beta-1 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Beta-2 adrenergic receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump AC50 300000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Bile salt export pump IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Bile salt export pump IC50 135000.0 nM 10.1093/toxsci/kfq269
Homo sapiens Bradykinin B2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Canalicular multispecific organic anion transporter 1 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Canalicular multispecific organic anion transporter 2 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Cannabinoid CB1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Carbonic anhydrase IC50 1860.0 nM 10.1016/j.bmc.2014.08.014
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2008.12.035
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2009.05.002
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2009.05.063
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2009.06.006
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2010.06.056
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2010.12.048
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2011.02.015
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2011.06.038
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2011.10.015
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2012.01.007
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2012.07.024
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2013.06.035
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2013.07.044
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2014.01.031
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2014.04.006
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2014.07.048
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2014.12.009
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2015.02.045
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2015.03.081
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2016.01.037
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmc.2017.05.007
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmcl.2006.01.044
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmcl.2008.07.010
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmcl.2008.10.093
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmcl.2009.04.123
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmcl.2011.01.050
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmcl.2015.10.074
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmcl.2015.11.104
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmcl.2016.02.032
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmcl.2016.07.060
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1016/j.bmcl.2016.12.035
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1021/jm0512600
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1021/jm060531j
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1021/jm1013242
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1021/jm200209n
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1021/jm300112w
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1021/jm4000616
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1021/jm9000488
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1021/jm9003126
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1021/jm900914e
Homo sapiens Carbonic anhydrase I Ki 56.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase I Ki 250.0 nM 10.1021/acs.jmedchem.0c01889
Homo sapiens Carbonic anhydrase I Ki 14800.0 nM 10.1016/j.bmcl.2011.12.069
Homo sapiens Carbonic anhydrase I Ki 14800.0 nM 10.1016/j.ejmech.2011.12.022
Homo sapiens Carbonic anhydrase I Kinact 0.056 uM 10.1016/j.bmc.2009.11.021
Homo sapiens Carbonic anhydrase I Kinact 35.0 nM 10.1021/jm9014026
Homo sapiens Carbonic anhydrase I Kinact 56.0 nM 10.1016/j.bmcl.2006.12.107
Homo sapiens Carbonic anhydrase I Kinact 56.0 nM 10.1016/j.bmcl.2007.04.063
Homo sapiens Carbonic anhydrase I Kinact 56.0 nM 10.1016/j.bmcl.2007.12.022
Homo sapiens Carbonic anhydrase I NT nan None 10.1021/jm0109199
Homo sapiens Carbonic anhydrase II Kd 47.6 nM 10.1016/j.bmc.2007.03.070
Homo sapiens Carbonic anhydrase II Kd nan None 10.1021/jm7015649
Homo sapiens Carbonic anhydrase II Ki 10.3 nM 10.1016/j.bmcl.2005.03.032
Homo sapiens Carbonic anhydrase II Ki 10.4 nM 10.1021/acs.jmedchem.0c01889
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2008.12.035
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2009.05.002
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2009.05.063
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2009.06.006
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2010.06.056
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2010.12.048
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2011.02.015
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2011.06.038
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2011.10.015
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2012.01.007
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2012.07.024
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2013.06.035
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2013.07.044
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2014.01.031
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2014.04.006
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2014.07.048
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2014.12.009
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2015.02.045
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2015.03.081
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2016.01.037
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmc.2017.05.007
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2006.01.044
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2008.07.010
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2008.10.093
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2009.04.123
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2009.10.009
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2011.01.050
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2013.11.021
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2015.06.079
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2015.10.074
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2015.11.104
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2016.01.023
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2016.02.032
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2016.07.060
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1016/j.bmcl.2016.12.035
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1021/jm0512600
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1021/jm060531j
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1021/jm1013242
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1021/jm200209n
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1021/jm300112w
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1021/jm300203r
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1021/jm4000616
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1021/jm9000488
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1021/jm9003126
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1021/jm900914e
Homo sapiens Carbonic anhydrase II Ki 35.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase II Ki 35.2 nM 10.1016/j.bmcl.2005.03.032
Homo sapiens Carbonic anhydrase II Ki 68.1 nM 10.1016/j.bmc.2012.02.029
Homo sapiens Carbonic anhydrase II Ki 303.0 nM 10.1016/j.bmc.2012.02.029
Homo sapiens Carbonic anhydrase II Ki 1070.0 nM 10.1016/j.bmcl.2011.12.069
Homo sapiens Carbonic anhydrase II Ki 1070.0 nM 10.1016/j.ejmech.2011.12.022
Homo sapiens Carbonic anhydrase II Ki 4300.0 nM 10.1021/jm0109199
Homo sapiens Carbonic anhydrase II Ki 6800.0 nM 10.1021/jm7015649
Homo sapiens Carbonic anhydrase II Kinact 0.035 uM 10.1016/j.bmc.2009.11.021
Homo sapiens Carbonic anhydrase II Kinact 5.1 nM 10.1021/jm9014026
Homo sapiens Carbonic anhydrase II Kinact 35.0 nM 10.1016/j.bmcl.2006.12.107
Homo sapiens Carbonic anhydrase II Kinact 35.0 nM 10.1016/j.bmcl.2007.04.063
Homo sapiens Carbonic anhydrase II Kinact 35.0 nM 10.1016/j.bmcl.2007.12.022
Homo sapiens Carbonic anhydrase III Ki 2200000.0 nM 10.1016/j.bmc.2007.08.037
Homo sapiens Carbonic anhydrase III Ki 2200000.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase III Kinact 2.2 10^6nM 10.1016/j.bmcl.2007.12.022
Homo sapiens Carbonic anhydrase IV Ki 8590.0 nM 10.1016/j.bmcl.2008.10.093
Homo sapiens Carbonic anhydrase IV Ki 8590.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase IV Ki 38450.0 nM 10.1016/j.bmcl.2011.12.069
Homo sapiens Carbonic anhydrase IV Ki 38450.0 nM 10.1016/j.ejmech.2011.12.022
Homo sapiens Carbonic anhydrase IV Kinact 8590.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase IV Kinact 8590.0 nM 10.1016/j.bmcl.2007.12.022
Homo sapiens Carbonic anhydrase IX Ki 5.0 nM 10.1021/jm060531j
Homo sapiens Carbonic anhydrase IX Ki 5.0 nM 10.1021/jm900914e
Homo sapiens Carbonic anhydrase IX Ki 5.1 nM 10.1016/j.bmc.2011.10.015
Homo sapiens Carbonic anhydrase IX Ki 5.1 nM 10.1016/j.bmc.2013.07.044
Homo sapiens Carbonic anhydrase IX Ki 5.1 nM 10.1016/j.bmc.2014.01.031
Homo sapiens Carbonic anhydrase IX Ki 5.1 nM 10.1016/j.bmcl.2005.06.055
Homo sapiens Carbonic anhydrase IX Ki 5.1 nM 10.1021/jm300112w
Homo sapiens Carbonic anhydrase IX Ki 5.1 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase IX Ki 5.1 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase IX Kinact 5.0 nM 10.1016/j.bmcl.2006.12.107
Homo sapiens Carbonic anhydrase IX Kinact 5.1 nM 10.1016/j.bmcl.2007.12.022
Homo sapiens Carbonic anhydrase IX Kinact 5250.0 nM 10.1021/jm9014026
Homo sapiens Carbonic anhydrases; II & IX Selectivity ratio 7.0 None 10.1021/jm060531j
Homo sapiens Carbonic anhydrase V Ki 20.6 nM 10.1016/j.bmcl.2005.03.032
Homo sapiens Carbonic anhydrase VA Kd 20.6 nM 10.1016/j.bmc.2007.03.070
Homo sapiens Carbonic anhydrase VA Ki 20.0 nM 10.1016/j.bmc.2009.06.006
Homo sapiens Carbonic anhydrase VA Ki 20.0 nM 10.1016/j.bmcl.2008.07.010
Homo sapiens Carbonic anhydrase VA Ki 20.0 nM 10.1016/j.bmcl.2011.01.050
Homo sapiens Carbonic anhydrase VA Ki 20.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase VA Ki 20000.0 nM 10.1016/j.bmcl.2008.10.093
Homo sapiens Carbonic anhydrase VA Kinact 20.0 nM 10.1016/j.bmc.2009.11.021
Homo sapiens Carbonic anhydrase VA Kinact 20.0 nM 10.1016/j.bmcl.2007.12.022
Homo sapiens Carbonic anhydrase VB Ki 6033.0 nM 10.1016/j.bmc.2009.06.006
Homo sapiens Carbonic anhydrase VB Ki 6033.0 nM 10.1016/j.bmcl.2008.07.010
Homo sapiens Carbonic anhydrase VB Ki 6033.0 nM 10.1016/j.bmcl.2011.01.050
Homo sapiens Carbonic anhydrase VB Ki 6033.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase VB Ki 6033000.0 nM 10.1016/j.bmcl.2008.10.093
Homo sapiens Carbonic anhydrase VB Kinact 6033.0 nM 10.1016/j.bmc.2009.11.021
Homo sapiens Carbonic anhydrase VB Kinact 6033.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase VB Kinact 6033.0 nM 10.1016/j.bmcl.2007.12.022
Homo sapiens Carbonic anhydrase VI Ki 89.0 nM 10.1021/jm801267c
Homo sapiens Carbonic anhydrase VI Ki 89.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase VI Ki 2420.0 nM 10.1016/j.bmcl.2011.12.069
Homo sapiens Carbonic anhydrase VI Ki 2420.0 nM 10.1016/j.ejmech.2011.12.022
Homo sapiens Carbonic anhydrase VI Ki nan None 10.1016/j.bmcl.2010.11.124
Homo sapiens Carbonic anhydrase VI Kinact 89.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase VI Kinact 89.0 nM 10.1016/j.bmcl.2007.12.022
Homo sapiens Carbonic anhydrase VII Ki 0.9 nM 10.1021/acs.jmedchem.0c01889
Homo sapiens Carbonic anhydrase VII Ki 117.0 nM 10.1016/j.bmc.2013.06.035
Homo sapiens Carbonic anhydrase VII Ki 117.0 nM 10.1016/j.bmc.2013.07.044
Homo sapiens Carbonic anhydrase VII Ki 117.0 nM 10.1016/j.bmcl.2009.04.123
Homo sapiens Carbonic anhydrase VII Ki 117.0 nM 10.1016/j.ejmech.2013.10.071
Homo sapiens Carbonic anhydrase VII Ki 117.0 nM 10.1021/jm200209n
Homo sapiens Carbonic anhydrase VII Ki 117.0 nM 10.1021/jm300112w
Homo sapiens Carbonic anhydrase VII Ki 117.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase VII Kinact 117.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase VII Kinact 117.0 nM 10.1016/j.bmcl.2007.12.022
Homo sapiens Carbonic anhydrase XII Ki 3.8 nM 10.1021/acs.jmedchem.0c01889
Homo sapiens Carbonic anhydrase XII Ki 11000.0 nM 10.1016/j.bmc.2013.07.044
Homo sapiens Carbonic anhydrase XII Ki 11000.0 nM 10.1016/j.bmc.2014.01.031
Homo sapiens Carbonic anhydrase XII Ki 11000.0 nM 10.1016/j.bmcl.2005.06.055
Homo sapiens Carbonic anhydrase XII Ki 11000.0 nM 10.1021/jm900914e
Homo sapiens Carbonic anhydrase XII Ki 11000.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase XII Kinact 11000.0 nM 10.1016/j.bmcl.2007.12.022
Homo sapiens Carbonic anhydrase XIII Ki 430.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase XIV Ki 5250.0 nM 10.1016/j.bmc.2011.10.015
Homo sapiens Carbonic anhydrase XIV Ki 5250.0 nM 10.1016/j.bmcl.2005.06.055
Homo sapiens Carbonic anhydrase XIV Ki 5250.0 nM 10.1021/jm200209n
Homo sapiens Carbonic anhydrase XIV Ki 5250.0 nM 10.1021/jm300112w
Homo sapiens Carbonic anhydrase XIV Ki 5250.0 nM 10.1021/jm901524f
Homo sapiens Carbonic anhydrase XIV Kinact 6.86 nM 10.1021/jm9014026
Homo sapiens Carbonic anhydrase XIV Kinact 5250.0 nM 10.1016/j.bmcl.2007.06.044
Homo sapiens Carbonic anhydrase XIV Kinact 5250.0 nM 10.1016/j.bmcl.2007.12.022
Homo sapiens Cholecystokinin A receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cyclooxygenase-2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Cytochrome P450 3A4 Activity nan None None
Homo sapiens Delta opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 5623.4 nM None
Homo sapiens Dopamine D1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine D3 receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Dopamine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Equilibrative nucleoside transporter 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Estrogen receptor alpha AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Geminin Potency 1412.5 nM None
Homo sapiens Ghrelin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Glucocorticoid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens HERG AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H1 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histamine H3 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Histone deacetylase 6 Inhibition -14.18 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -4.77 % 10.6019/CHEMBL4808148
Homo sapiens Homo sapiens DILI_Concern nan None 10.1016/j.drudis.2016.02.015
Homo sapiens Homo sapiens DILI_severity_class 2.0 None 10.1016/j.drudis.2016.02.015
Homo sapiens Kappa opioid receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 3 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Melanocortin receptor 4 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Mitochondrial amidoxime-reducing component 1 Activity nan None 10.1021/acs.jmedchem.9b01483
Homo sapiens Mitochondrial amidoxime reducing component 2 Activity nan None 10.1021/acs.jmedchem.9b01483
Homo sapiens Monoamine oxidase A AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Monoamine oxidase A Inhibition nan % 10.1021/jm101359c
Homo sapiens Monoamine oxidase B Ki 3100.0 nM 10.1016/j.ejmech.2018.01.003
Homo sapiens Monoamine oxidase B Ki 3100.0 nM 10.1021/jm101359c
Homo sapiens Monoamine oxidase B Ki 30800.0 nM 10.1016/j.ejmech.2018.01.003
Homo sapiens Motilin receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Multidrug resistance-associated protein 4 IC50 133000.0 nM 10.1093/toxsci/kft176
Homo sapiens Mu opioid receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M2 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Muscarinic acetylcholine receptor M3 AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuronal acetylcholine receptor protein alpha-4 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Neuropeptide Y receptor type 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Norepinephrine transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens PC-3 FC 1.035 None 10.1038/nchembio790
Homo sapiens Phosphodiesterase 3A AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Phosphodiesterase 4D AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Pregnane X receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Prelamin-A/C Potency 891.3 nM None
Homo sapiens Progesterone receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 1a (5-HT1a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2a (5-HT2a) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2b (5-HT2b) receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 2c (5-HT2c) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin 3a (5-HT3a) receptor AC50 30000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serotonin transporter AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Serum Drug uptake 0.6 uM 10.1021/jm101359c
Homo sapiens Thromboxane A2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Type-1 angiotensin II receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V1a receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Homo sapiens Vasopressin V2 receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Klebsiella pneumoniae Klebsiella pneumoniae Inhibition 12.91 % 10.6019/CHEMBL4513141
Macaca fascicularis Brain Fu 0.386 None 10.1124/dmd.111.038778
Mus musculus Aquaporin-4 Activity nan None 10.1016/j.bmc.2008.06.005
Mus musculus Brain Fu 0.299 None 10.1124/dmd.111.038778
Mus musculus Carbonic anhydrase 15 Ki 634.0 nM 10.1021/jm801267c
Mus musculus Carbonic anhydrase 15 Ki 634.0 nM 10.1021/jm901524f
Mus musculus Carbonic anhydrase XIII Kinact 430.0 nM 10.1016/j.bmcl.2007.06.044
Mus musculus Carbonic anhydrase XIII Kinact 430.0 nM 10.1016/j.bmcl.2007.12.022
Mus musculus Monoamine oxidase B IC50 24800.0 nM 10.1016/j.bmcl.2019.126677
Mus musculus Mus musculus Block 20.0 % 10.1021/jm00388a023
Mus musculus Mus musculus Block 40.0 % 10.1021/jm00388a023
Mus musculus Mus musculus Block 50.0 % 10.1021/jm00388a023
Mus musculus Mus musculus Block nan None 10.1021/jm00388a023
Mus musculus Mus musculus ED50 20.0 mg.kg-1 10.1016/j.bmcl.2015.08.071
Mus musculus Mus musculus ED50 20.0 mg.kg-1 10.1016/j.bmcl.2017.07.037
Mus musculus Mus musculus ED50 20.0 mg.kg-1 10.1021/jm00188a011
Mus musculus Mus musculus ED50 500.0 mg.kg-1 10.1016/j.bmcl.2015.08.071
Mus musculus Mus musculus ED50 500.0 mg.kg-1 10.1016/j.bmcl.2017.07.037
Mus musculus Mus musculus TD50 292.0 mg kg-1 10.1021/jm00188a011
Mycobacterium tuberculosis Carbonic anhydrase Ki 876.0 nM 10.1016/j.bmcl.2009.10.009
Mycobacterium tuberculosis PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Ki 210.0 nM 10.1021/jm1013242
Mycobacterium tuberculosis Uncharacterized protein Rv1284/MT1322 Ki 28680.0 nM 10.1021/jm9003126
Mycobacterium tuberculosis Uncharacterized protein Rv1284/MT1322 Ki 286800.0 nM 10.1021/jm1013242
Plasmodium falciparum Plasmodium falciparum Potency 2616.9 nM None
Plasmodium falciparum Plasmodium falciparum Potency 18526.0 nM None
Pseudomonas aeruginosa Pseudomonas aeruginosa Inhibition 11.37 % 10.6019/CHEMBL4513141
Rattus norvegicus Androgen Receptor AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Brain Fu 0.327 None 10.1124/dmd.111.038778
Rattus norvegicus Brain Fu 0.598 None 10.1124/dmd.111.038778
Rattus norvegicus Cyclooxygenase-1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus GABA receptor alpha-1 subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 AC50 10000.0 nM 10.1038/s41467-023-40064-9
Rattus norvegicus Monoamine oxidase A Inhibition nan % 10.1021/jm101359c
Rattus norvegicus Monoamine oxidase B Ki 2900.0 nM 10.1016/j.ejmech.2018.01.003
Rattus norvegicus Monoamine oxidase B Ki 2900.0 nM 10.1021/jm101359c
Rattus norvegicus Rattus norvegicus Activity -37.6 % 10.1016/j.bmcl.2015.08.071
Rattus norvegicus Rattus norvegicus Activity -37.6 % 10.1016/j.bmcl.2017.07.037
Rattus norvegicus Rattus norvegicus Activity 5.1 % 10.1016/j.bmcl.2015.08.071
Rattus norvegicus Rattus norvegicus Activity 5.1 % 10.1016/j.bmcl.2017.07.037
Rattus norvegicus Rattus norvegicus Activity 7.0 % 10.1016/j.bmcl.2015.08.071
Rattus norvegicus Rattus norvegicus Activity 7.0 % 10.1016/j.bmcl.2017.07.037
Rattus norvegicus Rattus norvegicus Activity 45.9 % 10.1016/j.bmcl.2015.08.071
Rattus norvegicus Rattus norvegicus Activity 45.9 % 10.1016/j.bmcl.2017.07.037
Rattus norvegicus Rattus norvegicus ED50 21.0 mg.kg-1 10.1016/j.bmc.2008.03.051
Rattus norvegicus Rattus norvegicus ED50 100.0 umol.kg-1 10.1021/jm200209n
Rattus norvegicus Rattus norvegicus ED50 300.0 mg.kg-1 10.1016/j.bmc.2008.03.051
Rattus norvegicus Rattus norvegicus MED 100.0 mg kg-1 10.1021/jm000155h
Rattus norvegicus Rattus norvegicus PI 9.1 None 10.1016/j.bmc.2008.03.051
Rattus norvegicus Rattus norvegicus TD50 192.0 mg kg-1 10.1016/j.bmc.2008.03.051
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 31622.8 nM None
Rattus norvegicus Voltage-gated L-type calcium channel alpha-1C subunit AC50 10000.0 nM 10.1038/s41467-023-40064-9
Saccharomyces cerevisiae S288c Carbonic anhydrase Ki 106.0 nM 10.1016/j.bmc.2008.12.035
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 7.575 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 10.77 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Hit score 0.02562 None 10.1101/2020.04.21.054387
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.05 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.01 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 16.73 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition index -0.006148 None 10.1101/2020.04.03.023846
Staphylococcus aureus Staphylococcus aureus Inhibition 1.04 % 10.6019/CHEMBL4513141
Stylophora pistillata Alpha carbonic anhydrase Ki 259.0 nM 10.1016/j.bmc.2009.05.063
Stylophora pistillata Alpha carbonic anhydrase Ki 259.0 nM 10.1016/j.bmcl.2010.11.124
Stylophora pistillata Carbonic anhydrase Ki 645.0 nM 10.1016/j.bmcl.2010.11.124
Sulfurihydrogenibium sp. (strain YO3AOP1) Carbonate dehydratase Ki 140.0 nM 10.1016/j.bmcl.2015.11.104
Thalassiosira weissflogii Delta carbonic anhydrase Ki 404.0 nM 10.1016/j.bmcl.2013.11.021
Thiomicrospira crunogena (strain XCL-2) Carbonic anhydrase, alpha family Ki 411.0 nM 10.1016/j.bmcl.2015.11.104
None ADMET DNAUC 663.0 kg.min/L 10.1080/00498250400028197
None ADMET DNAUC 1458.0 kg.min/L 10.1080/00498250400028197
None ADMET DNAUC 2097.0 kg.min/L 10.1080/00498250400028197
None ADMET DNAUC 3030.0 kg.min/L 10.1080/00498250400028197
None ADMET Fu 0.389 None 10.1124/dmd.111.038778
None Hepatotoxicity HepSE_bilirubinemia 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholecystitis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cholelithiasis 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_cirrhosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_Combined Scores 3.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_elevated liver function tests 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic failure 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatic necrosis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatitis 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_hepatomegaly 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_jaundice 1.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver disease 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver fatty 0.0 None 10.1371/journal.pcbi.1002310
None Hepatotoxicity HepSE_liver function tests abnormal 0.0 None 10.1371/journal.pcbi.1002310
None NON-PROTEIN TARGET ED50 20.0 mg.kg-1 10.1016/j.bmcl.2016.11.035
None NON-PROTEIN TARGET ED50 500.0 mg.kg-1 10.1016/j.bmcl.2016.11.035
None NON-PROTEIN TARGET Fu 0.308 None 10.1124/dmd.111.038778
None NON-PROTEIN TARGET Hepatotoxicity (acute) 0.0 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (animal toxicity known) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (benign tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (granulomatous hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (mechanism) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 2.0 None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (moderate) 4.2 % 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Hepatotoxicity (time to onset) nan None 10.1016/s0399-8320(04)95062-2
None NON-PROTEIN TARGET Potency 1.2 nM None
None NON-PROTEIN TARGET Potency 2.7 nM None
None No relevant target CLogP -0.363 None 10.1021/jm0109199
None No relevant target LogD7.4 0.55 None 10.6019/CHEMBL3301361
None No relevant target Solubility 500000.0 nM 10.1016/j.bmcl.2010.10.068
None Unchecked Ac50 0.3981 uM None
None Unchecked Ac50 4.467 uM None
None Unchecked Ac50 8.913 uM None
None Unchecked Ac50 10.0 uM None
None Unchecked Ac50 39.81 uM None
None Unchecked AC50 400.0 nM None
None Unchecked AC50 4466.8 nM None
None Unchecked AC50 8912.5 nM None
None Unchecked AC50 10000.0 nM None
None Unchecked AC50 39810.7 nM None
None Unchecked Anticonvulsant activity nan None 10.1016/s0960-894x(03)00535-3
None Unchecked Fold change 2.3 None 10.1016/j.bmc.2007.03.070
None Unchecked Hepatotoxicity (acute) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (association with vascular disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (choleostasis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (chronic liver disease) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cirrhosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (comment) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (cytolytic) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (malignant tumour) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (severe hepatitis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (steatosis) 0.0 None 10.1016/s0399-8320(04)95062-2
None Unchecked Hepatotoxicity (successful reintroduction) nan None 10.1016/s0399-8320(04)95062-2
None Unchecked IC50 3300.0 nM 10.1016/j.bmc.2007.12.038
None Unchecked Imax 48.0 % 10.1016/j.bmc.2007.12.038
None Unchecked Inhibition 40.0 % 10.1016/j.ejmech.2016.07.032
None Unchecked Inhibition 48.0 % 10.1016/j.bmc.2007.12.038
None Unchecked Inhibition 60.0 % 10.1016/j.ejmech.2016.07.032
None Unchecked Ki 13.0 nM 10.1016/j.bmc.2010.06.056
None Unchecked Ki 52.9 nM 10.1016/j.bmcl.2015.10.074
None Unchecked Ki 57.3 nM 10.1016/j.bmc.2012.02.029
None Unchecked Ki 85.6 nM 10.1016/j.bmc.2015.02.045
None Unchecked Ki 85.6 nM 10.1016/j.bmcl.2015.06.079
None Unchecked Ki 85.6 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 128.0 nM 10.1016/j.bmcl.2016.02.032
None Unchecked Ki 140.0 nM 10.1016/j.bmc.2012.07.024
None Unchecked Ki 157.0 nM 10.1016/j.bmc.2014.07.048
None Unchecked Ki 157.0 nM 10.1016/j.bmc.2015.02.045
None Unchecked Ki 157.0 nM 10.1016/j.bmcl.2013.11.021
None Unchecked Ki 157.0 nM 10.1016/j.bmcl.2013.11.030
None Unchecked Ki 157.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 208.0 nM 10.1021/jm9003126
None Unchecked Ki 231.0 nM 10.1016/j.bmc.2012.07.024
None Unchecked Ki 246.0 nM 10.1016/j.bmc.2014.12.009
None Unchecked Ki 250.0 nM 10.1021/jm9014026
None Unchecked Ki 254.0 nM 10.1016/j.bmc.2014.04.006
None Unchecked Ki 254.0 nM 10.1016/j.bmc.2014.07.048
None Unchecked Ki 345.0 nM 10.1016/j.bmc.2014.07.048
None Unchecked Ki 406.0 nM 10.1016/j.bmc.2010.12.048
None Unchecked Ki 490.0 nM 10.1016/j.bmcl.2015.06.079
None Unchecked Ki 490.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 517.0 nM 10.1016/j.bmc.2011.02.015
None Unchecked Ki 517.0 nM 10.1016/j.bmcl.2015.10.074
None Unchecked Ki 725.0 nM 10.1016/j.bmcl.2016.03.014
None Unchecked Ki 725.0 nM 10.1016/j.bmcl.2016.12.035
None Unchecked Ki 771.0 nM 10.1016/j.bmcl.2016.01.023
None Unchecked Ki 820.0 nM 10.1016/j.bmc.2014.04.006
None Unchecked Ki 831.0 nM 10.1016/j.bmc.2014.04.006
None Unchecked Ki 867.0 nM 10.1021/jm4000616
None Unchecked Ki 971.0 nM 10.1016/j.bmc.2009.05.002
None Unchecked Ki 982.0 nM 10.1016/j.bmc.2016.01.037
None Unchecked Ki 982.0 nM 10.1021/jm301611m
None Unchecked Ki 1850.0 nM 10.1016/j.bmc.2010.12.048
None Unchecked Ki 3620.0 nM 10.1016/j.bmcl.2015.04.037
None Unchecked Ki 4060.0 nM 10.1016/j.bmc.2017.05.007
None Unchecked Ki 5430.0 nM 10.1016/j.bmc.2011.06.038
None Unchecked Ki 5700.0 nM 10.1016/j.bmc.2011.06.038
None Unchecked Ki 7650.0 nM 10.1021/jm300203r
None Unchecked Ki 7890.0 nM 10.1016/j.bmcl.2016.07.060
None Unchecked Ki 8570.0 nM 10.1016/j.bmc.2016.01.037
None Unchecked Ki 8570.0 nM 10.1016/j.bmcl.2016.02.032
None Unchecked Ki 28680.0 nM 10.1021/jm9000488
None Unchecked Ki 50000.0 nM 10.1016/j.bmc.2017.05.007
None Unchecked Ki 50000.0 nM 10.1016/j.bmcl.2016.12.035
None Unchecked Ki 100000.0 nM 10.1016/j.bmcl.2013.11.021
None Unchecked Ki 100000.0 nM 10.1021/jm400939k
None Unchecked Ki nan None 10.1016/j.bmc.2015.02.045
None Unchecked Ki nan None 10.1016/j.bmcl.2013.11.030
None Unchecked Ki nan None 10.1016/j.bmcl.2015.06.079
None Unchecked Kinact 231.0 nM 10.1016/j.bmcl.2007.04.063
None Unchecked Kinact 254.0 nM 10.1016/j.bmcl.2007.04.063
None Unchecked Potency 3662.6 nM None
None Unchecked Ratio 10.0 None 10.1021/jm101359c
None Unchecked Ratio Ki 0.0001 None 10.1021/jm1013242
None Unchecked Ratio Ki 0.0002 None 10.1021/jm1013242
None Unchecked Ratio Ki 0.003 None 10.1016/j.bmc.2014.01.031
None Unchecked Ratio Ki 0.01 None 10.1021/jm9014026
None Unchecked Ratio Ki 0.04 None 10.1021/jm1013242
None Unchecked Ratio Ki 0.05 None 10.1016/j.bmc.2009.06.006
None Unchecked Ratio Ki 0.1 None 10.1021/jm1013242
None Unchecked Ratio Ki 0.15 None 10.1021/jm0512600
None Unchecked Ratio Ki 0.16 None 10.1016/j.bmcl.2006.01.044
None Unchecked Ratio Ki 0.2 None 10.1021/jm1013242
None Unchecked Ratio Ki 0.29 None 10.1016/j.bmcl.2009.04.123
None Unchecked Ratio Ki 0.3 None 10.1021/jm1013242
None Unchecked Ratio Ki 0.47 None 10.1016/j.bmcl.2009.04.123
None Unchecked Ratio Ki 4.3 None 10.1016/j.bmc.2010.06.056
None Unchecked Ratio Ki 6.9 None 10.1016/j.bmc.2013.07.044
None Unchecked Ratio Ki 6.9 None 10.1016/j.bmc.2014.01.031
None Unchecked Ratio Ki 7.0 None 10.1021/jm900914e
None Unchecked Ratio Ki 11.2 None 10.1021/jm900914e
None Unchecked Ratio Ki 406.0 None 10.1016/j.bmc.2014.12.009
None Unchecked Selectivity ratio 7.0 None 10.1016/j.bmcl.2006.12.107

Metabolism Information