G-52
AlkaPlorer ID: AK096168
Synonym: None
IUPAC Name: (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[[(2S,3R)-3-amino-6-(methylaminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
Structure
SMILES: CNCC1=CC[C@@H](N)[C@@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H](N)C[C@@H]2N)O1
InChI: InChI=1S/C20H39N5O7/c1-20(28)8-29-19(14(27)17(20)25-3)32-16-12(23)6-11(22)15(13(16)26)31-18-10(21)5-4-9(30-18)7-24-2/h4,10-19,24-28H,5-8,21-23H2,1-3H3/t10-,11+,12-,13+,14-,15-,16+,17-,18-,19-,20+/m1/s1
InChIKey: ARCVBMPERJRMKB-CPIRLDNISA-N
Reference
A new broad spectrum aminoglycoside antibiotic, G-52, produced by Micromonospora zionensis.
PubChem CID: 512868
LOTUS: LTS0042497
{NPAtlas: NPA021143
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Micromonospora zionensis | Micromonospora | Micromonosporaceae | Micromonosporales | Actinomycetes | Actinomycetota | None | Bacteria |
Properties Information
Molecule Weight: 461.5600000000002
TPSA？: 199.73
MolLogP？: -3.590799999999992
Number of H-Donors: 8
Number of H-Acceptors: 12
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bacillus subtilis | Bacillus subtilis | MIC | 0.01 | ug.mL-1 | 10.1021/jm00200a009 |
| Entamoeba histolytica | Entamoeba histolytica | Activity | nan | None | 10.1021/jm00200a009 |
| Escherichia coli | Escherichia coli | MIC | 0.3 | ug.mL-1 | 10.1021/jm00200a009 |
| Escherichia coli | Escherichia coli | MIC | 0.75 | ug.mL-1 | 10.1021/jm00200a009 |
| Escherichia coli | Escherichia coli | MIC | 17.5 | ug.mL-1 | 10.1021/jm00200a009 |
| Escherichia coli | Escherichia coli | MIC | 25.0 | ug.mL-1 | 10.1021/jm00200a009 |
| Klebsiella pneumoniae | Klebsiella pneumoniae | MIC | 0.075 | ug.mL-1 | 10.1021/jm00200a009 |
| Klebsiella pneumoniae | Klebsiella pneumoniae | MIC | 25.0 | ug.mL-1 | 10.1021/jm00200a009 |
| Mus musculus | Mus musculus | LD50 | 50.0 | mg.kg-1 | 10.1021/jm00200a009 |
| Proteus mirabilis | Proteus mirabilis | MIC | 0.75 | ug.mL-1 | 10.1021/jm00200a009 |
| Providencia | Providencia | MIC | 25.0 | ug.mL-1 | 10.1021/jm00200a009 |
| Providencia rettgeri | Providencia rettgeri | MIC | 3.0 | ug.mL-1 | 10.1021/jm00200a009 |
| Providencia rettgeri | Providencia rettgeri | MIC | 25.0 | ug.mL-1 | 10.1021/jm00200a009 |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | MIC | 0.3 | ug.mL-1 | 10.1021/jm00200a009 |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | MIC | 25.0 | ug.mL-1 | 10.1021/jm00200a009 |
| Salmonella enterica subsp. enterica serovar Typhimurium | Salmonella typhimurium | MIC | 3.0 | ug.mL-1 | 10.1021/jm00200a009 |
| Serratia marcescens | Serratia marcescens | MIC | 0.3 | ug.mL-1 | 10.1021/jm00200a009 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 0.01 | ug.mL-1 | 10.1021/jm00200a009 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 0.03 | ug.mL-1 | 10.1021/jm00200a009 |
| Streptococcus pyogenes | Streptococcus pyogenes | MIC | 0.3 | ug.mL-1 | 10.1021/jm00200a009 |
| Streptococcus pyogenes | Streptococcus pyogenes | MIC | 3.0 | ug.mL-1 | 10.1021/jm00200a009 |
| Streptococcus pyogenes | Streptococcus pyogenes | MIC | 25.0 | ug.mL-1 | 10.1021/jm00200a009 |
| Trichomonas vaginalis | Trichomonas vaginalis | Activity | nan | None | 10.1021/jm00200a009 |
| None | NON-PROTEIN TARGET | Activity | nan | None | 10.1021/jm00200a009 |