Peramivir
AlkaPlorer ID: AK096781
Synonym: None
IUPAC Name: (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid
Structure
SMILES: CCC(CC)[C@H](N=C(C)O)[C@@H]1[C@H](O)[C@@H](C(=O)O)C[C@H]1NC(=N)N
InChI: InChI=1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19)/t9-,10+,11+,12-,13+/m0/s1
InChIKey: XRQDFNLINLXZLB-CKIKVBCHSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 328.41300000000007
TPSA？: 152.02000000000004
MolLogP？: 0.7008700000000014
Number of H-Donors: 6
Number of H-Acceptors: 4
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Canis lupus familiaris | MDCK | CC50 | 100000.0 | nM | 10.1016/j.ejmech.2017.12.072 |
| Canis lupus familiaris | MDCK | CC50 | 100000.0 | nM | 10.1016/j.ejmech.2021.113929 |
| Canis lupus familiaris | MDCK | CC50 | 100000.0 | nM | 10.1021/acs.jmedchem.6b00029 |
| Canis lupus familiaris | MDCK | CC50 | 200000.0 | nM | 10.1016/j.ejmech.2020.112048 |
| Canis lupus familiaris | MDCK | CC50 | 373000.0 | nM | 10.1016/j.bmcl.2017.11.003 |
| Clostridium perfringens | Sialidase | IC50 | 39600.0 | nM | 10.1016/j.bmcl.2017.11.003 |
| Homo sapiens | Histone deacetylase 6 | Inhibition | -29.82 | % | 10.6019/CHEMBL4808148 |
| Homo sapiens | Histone deacetylase 6 | Inhibition | -2.34 | % | 10.6019/CHEMBL4808148 |
| Homo sapiens | Homo sapiens | Activity | 1.0 | % | 10.1128/aac.00474-10 |
| Homo sapiens | Homo sapiens | Activity | 2.0 | % | 10.1128/aac.00474-10 |
| Homo sapiens | Homo sapiens | Activity | 3.0 | % | 10.1128/aac.00474-10 |
| Homo sapiens | Homo sapiens | Activity | 6.1 | % | 10.1128/aac.00474-10 |
| Homo sapiens | Homo sapiens | Activity | 14.1 | % | 10.1128/aac.00474-10 |
| Homo sapiens | Homo sapiens | Activity | 15.2 | % | 10.1128/aac.00474-10 |
| Homo sapiens | Homo sapiens | Activity | nan | None | 10.1128/aac.00474-10 |
| Homo sapiens | Homo sapiens | Cmax | 30449.74 | nM | 10.1128/aac.00334-09 |
| Homo sapiens | Plasma | Cp | 5.01 | ng/ml | 10.1128/aac.00474-10 |
| Homo sapiens | Plasma | Cp | 10.7 | ng/ml | 10.1128/aac.00474-10 |
| Homo sapiens | Plasma | Cp | 14.8 | ng/ml | 10.1128/aac.00474-10 |
| Homo sapiens | Plasma | Cp | 32.8 | ng/ml | 10.1128/aac.00474-10 |
| Homo sapiens | Plasma | Cp | 18100.0 | ng/ml | 10.1128/aac.00474-10 |
| Homo sapiens | Plasma | Cp | 36300.0 | ng/ml | 10.1128/aac.00474-10 |
| Homo sapiens | Sialidase 1 | IC50 | 500000.0 | nM | 10.1016/j.bmc.2018.05.035 |
| Homo sapiens | Sialidase 1 | IC50 | 500000.0 | nM | 10.1021/acs.jmedchem.1c01612 |
| Homo sapiens | Sialidase 1 | Ki | nan | None | 10.1016/j.bmc.2018.05.035 |
| Homo sapiens | Sialidase 2 | IC50 | 70000.0 | nM | 10.1016/j.bmc.2018.05.035 |
| Homo sapiens | Sialidase 2 | Ki | 56000.0 | nM | 10.1016/j.bmc.2018.05.035 |
| Homo sapiens | Sialidase 2 | Ki | 330000.0 | nM | 10.1021/jm100078r |
| Homo sapiens | Sialidase 3 | IC50 | 500000.0 | nM | 10.1016/j.bmc.2018.05.035 |
| Homo sapiens | Sialidase 3 | IC50 | 500000.0 | nM | 10.1021/acs.jmedchem.1c01612 |
| Homo sapiens | Sialidase 3 | Ki | nan | None | 10.1016/j.bmc.2018.05.035 |
| Homo sapiens | Sialidase 4 | IC50 | 500000.0 | nM | 10.1016/j.bmc.2018.05.035 |
| Homo sapiens | Sialidase 4 | IC50 | 500000.0 | nM | 10.1021/acs.jmedchem.1c01612 |
| Homo sapiens | Sialidase 4 | Ki | nan | None | 10.1016/j.bmc.2018.05.035 |
| Influenza A virus | Influenza A virus | Activity | nan | None | 10.1021/acs.jmedchem.1c01531 |
| Influenza A virus | Influenza A virus | Activity | nan | None | 10.1128/aac.01681-09 |
| Influenza A virus | Influenza A virus | EC50 | 1.5 | nM | 10.1021/acs.jmedchem.6b00029 |
| Influenza A virus | Influenza A virus | EC50 | 6.68 | nM | 10.1016/j.ejmech.2017.12.072 |
| Influenza A virus | Influenza A virus | EC50 | 643.0 | nM | 10.1016/j.ejmech.2017.12.072 |
| Influenza A virus | Influenza A virus | EC50 | 5260.0 | nM | 10.1016/j.ejmech.2020.112048 |
| Influenza A virus | Influenza A virus | EC50 | 5260.0 | nM | 10.1016/j.ejmech.2021.113929 |
| Influenza A virus | Influenza A virus | FC | 1.5 | None | 10.1128/aac.01681-09 |
| Influenza A virus | Influenza A virus | FC | 5.0 | None | 10.1128/aac.01681-09 |
| Influenza A virus | Influenza A virus | IC50 | 0.08 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.11 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.12 | nM | 10.1016/j.bmcl.2011.09.076 |
| Influenza A virus | Influenza A virus | IC50 | 0.12 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.14 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.18 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.19 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.2 | nM | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | IC50 | 0.2 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.28 | nM | 10.1128/aac.01608-09 |
| Influenza A virus | Influenza A virus | IC50 | 0.3 | nM | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | IC50 | 0.32 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.41 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.43 | nM | 10.1128/aac.01608-09 |
| Influenza A virus | Influenza A virus | IC50 | 0.49 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.5 | nM | 10.1128/aac.01608-09 |
| Influenza A virus | Influenza A virus | IC50 | 0.51 | nM | 10.1128/aac.01608-09 |
| Influenza A virus | Influenza A virus | IC50 | 0.55 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.7 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.75 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 0.86 | nM | 10.1016/j.bmcl.2011.09.076 |
| Influenza A virus | Influenza A virus | IC50 | 0.9 | nM | 10.1128/aac.01608-09 |
| Influenza A virus | Influenza A virus | IC50 | 1.0 | nM | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | IC50 | 1.47 | nM | 10.1128/aac.01608-09 |
| Influenza A virus | Influenza A virus | IC50 | 1.72 | nM | 10.1128/aac.00474-10 |
| Influenza A virus | Influenza A virus | IC50 | 3.0 | nM | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | IC50 | 3.51 | nM | 10.1128/aac.00474-10 |
| Influenza A virus | Influenza A virus | IC50 | 9.24 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 9.43 | nM | 10.1128/aac.00474-10 |
| Influenza A virus | Influenza A virus | IC50 | 11.79 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 12.5 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 13.06 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 13.75 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 14.96 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 27.0 | nM | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | IC50 | 33.56 | nM | 10.1128/aac.01608-09 |
| Influenza A virus | Influenza A virus | IC50 | 43.6 | nM | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | IC50 | 82.8 | nM | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | IC50 | 83.4 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 84.8 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 95.5 | nM | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | IC50 | 97.56 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 105.02 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 121.76 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 128.15 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 142.4 | nM | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | IC50 | 149.59 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 150.24 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 161.79 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 162.58 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 194.96 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 197.1 | nM | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | IC50 | 200.0 | nM | 10.1016/j.bmc.2008.11.075 |
| Influenza A virus | Influenza A virus | IC50 | 213.0 | nM | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | IC50 | 214.07 | nM | 10.1128/aac.01608-09 |
| Influenza A virus | Influenza A virus | IC50 | 562.1 | nM | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | IC50 | 891.4 | nM | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | IC50 | 1720.0 | nM | 10.1016/j.bmcl.2017.11.003 |
| Influenza A virus | Influenza A virus | IC50 | nan | None | 10.1128/aac.01608-09 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 1.0 | None | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 1.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 4.0 | None | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 12.0 | None | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 66.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 84.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 89.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 93.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 108.0 | None | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 111.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 125.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 136.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 140.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 164.0 | None | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 173.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 330.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 332.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 347.0 | None | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 398.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 400.0 | None | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 488.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 533.0 | None | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 609.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 641.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 751.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 831.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 893.0 | None | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 1095.0 | None | 10.1128/aac.00581-10 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 2106.0 | None | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | Ratio IC50 | 3340.0 | None | 10.1128/aac.00334-09 |
| Influenza A virus | Influenza A virus | Survival | 50.0 | % | 10.1128/aac.01681-09 |
| Influenza A virus | Influenza A virus | Survival | 100.0 | % | 10.1128/aac.01681-09 |
| Influenza A virus | Influenza A virus | TIME | 50.5 | hr | 10.1128/aac.00474-10 |
| Influenza A virus | Influenza A virus | TIME | 52.5 | hr | 10.1128/aac.00474-10 |
| Influenza A virus | Influenza A virus | TIME | 62.6 | hr | 10.1128/aac.00474-10 |
| Influenza A virus | Influenza A virus | TIME | 76.1 | hr | 10.1128/aac.00474-10 |
| Influenza A virus | Neuraminidase | IC50 | 0.07 | nM | 10.1021/acs.jmedchem.6b00029 |
| Influenza A virus | Neuraminidase | IC50 | 0.1 | nM | 10.1039/C4MD00168K |
| Influenza A virus | Neuraminidase | IC50 | 0.3 | nM | 10.1016/j.ejmech.2017.12.072 |
| Influenza A virus | Neuraminidase | IC50 | 0.3 | nM | 10.1021/acs.jmedchem.6b00029 |
| Influenza A virus | Neuraminidase | IC50 | 0.7 | nM | 10.1021/acs.jmedchem.6b00029 |
| Influenza A virus | Neuraminidase | IC50 | 0.8 | nM | 10.1021/acs.jmedchem.6b00029 |
| Influenza A virus | Neuraminidase | IC50 | 3.3 | nM | 10.1021/acs.jmedchem.6b00029 |
| Influenza A virus | Neuraminidase | IC50 | 3.6 | nM | 10.1016/j.ejmech.2017.12.072 |
| Influenza A virus | Neuraminidase | IC50 | 3.6 | nM | 10.1021/acs.jmedchem.6b00029 |
| Influenza A virus | Neuraminidase | IC50 | 18.4 | nM | 10.1016/j.ejmech.2017.12.072 |
| Influenza A virus | Neuraminidase | IC50 | 23.1 | nM | 10.1016/j.ejmech.2017.12.072 |
| Influenza A virus | Neuraminidase | IC50 | 92.5 | nM | 10.1016/j.ejmech.2017.12.072 |
| Influenza A virus | Neuraminidase | IC50 | 146.0 | nM | 10.1016/j.ejmech.2017.12.072 |
| Influenza A virus | Neuraminidase | IC50 | 146.0 | nM | 10.1021/acs.jmedchem.6b00029 |
| Influenza A virus | Neuraminidase | IC50 | 225.0 | nM | 10.1021/acs.jmedchem.6b00029 |
| Influenza A virus | Neuraminidase | IC50 | 451.0 | nM | 10.1016/j.ejmech.2017.12.072 |
| Influenza A virus | Neuraminidase | IC50 | 10000.0 | nM | 10.1016/j.ejmech.2007.04.011 |
| Influenza A virus | Neuraminidase | Inhibition | nan | % | 10.1016/j.bmcl.2011.09.076 |
| Influenza A virus (A/Memphis/1/1971(H3N2)) | Neuraminidase | IC50 | 2.0 | nM | 10.1016/j.ejmech.2017.12.072 |
| Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Neuraminidase | IC50 | 1.0 | nM | 10.1021/jm010277p |
| Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Neuraminidase | IC50 | 1.4 | nM | 10.1021/jm0002679 |
| Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza Avirus (strain A/South Carolina/1/1918 H1N1)) | Neuraminidase | IC50 | 3.4 | nM | 10.1016/j.bmcl.2011.09.076 |
| Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza Avirus (strain A/South Carolina/1/1918 H1N1)) | Neuraminidase | Inhibition | nan | % | 10.1016/j.bmcl.2011.09.076 |
| Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza Avirus (strain A/South Carolina/1/1918 H1N1)) | Neuraminidase | Ki | 0.83 | nM | 10.1016/j.bmcl.2011.09.076 |
| Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1)) | Neuraminidase | IC50 | 0.4 | nM | 10.1016/j.ejmech.2017.12.072 |
| Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1)) | Neuraminidase | IC50 | 0.48 | nM | 10.1016/j.ejmech.2017.12.072 |
| Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1)) | Neuraminidase | T1/2 | 1.25 | hr | 10.1128/aac.01681-09 |
| Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1)) | Neuraminidase | T1/2 | 24.0 | hr | 10.1128/aac.01681-09 |
| Influenza B virus | Influenza B virus | IC50 | 3.0 | nM | 10.1128/aac.00474-10 |
| Influenza B virus (strain B/Lee/1940) | Neuraminidase | IC50 | 5.0 | nM | 10.1021/jm010277p |
| Influenza B virus (strain B/Lee/1940) | Neuraminidase | IC50 | 11.0 | nM | 10.1021/jm0002679 |
| Mus musculus | Mus musculus | Activity | nan | None | 10.1128/aac.01681-09 |
| Mus musculus | Mus musculus | Cmax | 89.22 | nM | 10.1128/aac.01681-09 |
| Mus musculus | Mus musculus | Cmax | 53835.15 | nM | 10.1128/aac.01681-09 |
| Mus musculus | Mus musculus | Mean day | 8.8 | None | 10.1021/jm0002679 |
| Mus musculus | Mus musculus | Mean day | 9.0 | None | 10.1021/jm0002679 |
| Mus musculus | Mus musculus | Survival | 1.0 | None | 10.1021/jm0002679 |
| Mus musculus | Mus musculus | Survival | 7.0 | None | 10.1021/jm0002679 |
| Mus musculus | Mus musculus | Survival | 9.0 | None | 10.1021/jm0002679 |
| Severe acute respiratory syndrome coronavirus 2 | Replicase polyprotein 1ab | Inhibition | 9.502 | % | 10.6019/CHEMBL4495564 |
| Severe acute respiratory syndrome coronavirus 2 | Replicase polyprotein 1ab | Inhibition | 13.19 | % | 10.6019/CHEMBL4495564 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | Hit score | 0.03535 | None | 10.1101/2020.04.21.054387 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | Inhibition | -0.06 | % | 10.6019/CHEMBL4495565 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | Inhibition | 0.05 | % | 10.6019/CHEMBL4495565 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | Inhibition | 9.66 | % | 10.21203/rs.3.rs-23951/v1 |
| unidentified influenza virus | unidentified influenza virus | Activity | nan | None | 10.1128/aac.00474-10 |
| unidentified influenza virus | unidentified influenza virus | IC50 | 8400.0 | nM | 10.1016/j.bmc.2008.11.075 |
| unidentified influenza virus | unidentified influenza virus | Inhibition | 0.0 | % | 10.1128/aac.00474-10 |
| unidentified influenza virus | unidentified influenza virus | Inhibition | 1.1 | % | 10.1128/aac.00474-10 |
| unidentified influenza virus | unidentified influenza virus | Inhibition | 25.8 | % | 10.1128/aac.00474-10 |
| unidentified influenza virus | unidentified influenza virus | Inhibition | 36.8 | % | 10.1128/aac.00474-10 |
| unidentified influenza virus | unidentified influenza virus | TIME | 125.6 | hr | 10.1128/aac.00474-10 |
| unidentified influenza virus | unidentified influenza virus | TIME | 169.1 | hr | 10.1128/aac.00474-10 |
| None | ADMET | F | 2.5 | % | 10.1016/j.ejmech.2020.112423 |
| None | ADMET | Ratio CC50/EC50 | 19.0 | None | 10.1016/j.ejmech.2021.113929 |
| None | Unchecked | IC50 | 0.16 | nM | 10.1021/acs.jmedchem.2c01258 |
| None | Unchecked | IC50 | 2.1 | nM | 10.1021/jm100621s |
| None | Unchecked | IC50 | 2.8 | nM | 10.1021/jm100621s |
| None | Unchecked | IC50 | 13.0 | nM | 10.1021/jm100621s |
| None | Unchecked | IC50 | 14.0 | nM | 10.1021/jm100621s |
| None | Unchecked | IC50 | 16.7 | nM | 10.1016/j.ejmech.2017.12.072 |
| None | Unchecked | IC50 | 27.8 | nM | 10.1021/jm100621s |
| None | Unchecked | IC50 | 28.1 | nM | 10.1021/jm100621s |
| None | Unchecked | IC50 | 41.5 | nM | 10.1021/jm100621s |
| None | Unchecked | IC50 | 75.2 | nM | 10.1021/jm100621s |
| None | Unchecked | Inhibition | nan | % | 10.1021/acs.jnatprod.8b00656 |
| None | Unchecked | Ki | 0.3 | nM | 10.1021/jm100621s |
| None | Unchecked | Ki | 0.6 | nM | 10.1021/jm100621s |
| None | Unchecked | Ki | 0.7 | nM | 10.1021/jm100621s |
| None | Unchecked | Ki | 1.2 | nM | 10.1021/jm100621s |
| None | Unchecked | Ki | 2.3 | nM | 10.1021/jm100621s |
| None | Unchecked | Ki | 3.2 | nM | 10.1021/jm100621s |
| None | Unchecked | Ki | 8.2 | nM | 10.1021/jm100621s |
| None | Unchecked | Ki | 8.3 | nM | 10.1021/jm100621s |
| None | Unchecked | Ratio | 50.0 | None | 10.1021/jm010528u |
| None | Unchecked | Ratio | 1000.0 | None | 10.1021/jm010528u |
| None | Unchecked | Ratio CC50/EC50 | 38.0 | None | 10.1016/j.ejmech.2020.112048 |
| None | Unchecked | Ratio IC50 | 1.8 | None | 10.1021/jm100621s |
| None | Unchecked | Ratio IC50 | 2.0 | None | 10.1021/jm100621s |
| None | Unchecked | Ratio IC50 | 2.2 | None | 10.1021/jm100621s |
| None | Unchecked | Ratio IC50 | 2.7 | None | 10.1021/jm100621s |
| None | Unchecked | Ratio IC50 | 6.2 | None | 10.1021/jm100621s |
| None | Unchecked | Ratio IC50 | 6.7 | None | 10.1021/jm100621s |
| None | Unchecked | Ratio IC50 | 9.9 | None | 10.1021/jm100621s |
| None | Unchecked | Ratio IC50 | 17.3 | None | 10.1021/jm100621s |
| None | Unchecked | Ratio Ki | 4.6 | None | 10.1021/jm100621s |
| None | Unchecked | Ratio Ki | 6.9 | None | 10.1021/jm100621s |
| None | Unchecked | Ratio Ki | 7.7 | None | 10.1021/jm100621s |
| None | Unchecked | Ratio Ki | 13.7 | None | 10.1021/jm100621s |