Fumiquinazoline L
AlkaPlorer ID: AK100260
Synonym: None
IUPAC Name: (1R,2'S,3'aR,12R,14R)-12-methyl-2'-propan-2-ylspiro[13-oxa-2,10,17-triazatetracyclo[10.3.2.02,11.04,9]heptadeca-4,6,8,10-tetraene-14,4'-3,3a-dihydro-2H-imidazo[1,2-a]indole]-1',3,16-trione
Structure
SMILES: CC(C)[C@@H]1N[C@@H]2N(C1=O)C1=CC=CC=C1[C@]21C[C@@H]2C(O)=N[C@](C)(O1)C1=NC3=CC=CC=C3C(=O)N12
InChI: InChI=1S/C26H25N5O4/c1-13(2)19-22(34)30-17-11-7-5-9-15(17)26(24(30)28-19)12-18-20(32)29-25(3,35-26)23-27-16-10-6-4-8-14(16)21(33)31(18)23/h4-11,13,18-19,24,28H,12H2,1-3H3,(H,29,32)/t18-,19+,24-,25-,26-/m1/s1
InChIKey: SKGHZLVCSNWVQR-BPHHYWDRSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Scopulariopsis sp. | Scopulariopsis | Microascaceae | Microascales | Sordariomycetes | Ascomycota | Fungi | Eukaryota |
| Aspergillus sp. | Aspergillus | Aspergillaceae | Eurotiales | Eurotiomycetes | Ascomycota | Fungi | Eukaryota |
Properties Information
Molecule Weight: 471.5170000000002
TPSA？: 109.05
MolLogP？: 2.6967000000000008
Number of H-Donors: 2
Number of H-Acceptors: 7
RingCount: 8
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bacillus cereus | Bacillus cereus | Activity | nan | None | 10.1021/np4002042 |
| Bacillus subtilis | Bacillus subtilis | MIC | 100.0 | ug.mL-1 | 10.1021/np500683u |
| Bacillus subtilis | Bacillus subtilis | MIC | 50000.0 | nM | 10.1021/np4002042 |
| Candida albicans | Isocitrate lyase | Inhibition | nan | % | 10.1021/np500683u |
| Escherichia coli | Escherichia coli | Activity | nan | None | 10.1021/np4002042 |
| Escherichia coli | Escherichia coli | MIC | 100.0 | ug.mL-1 | 10.1021/np500683u |
| Homo sapiens | A549 | IC50 | 10000.0 | nM | 10.1021/np4002042 |
| Homo sapiens | A549 | IC50 | 100000.0 | nM | 10.1021/np500683u |
| Homo sapiens | Bel-7402 | Activity | nan | None | 10.1021/np4002042 |
| Homo sapiens | K562 | Activity | nan | None | 10.1021/np4002042 |
| Homo sapiens | K562 | IC50 | 100000.0 | nM | 10.1021/np500683u |
| Homo sapiens | SGC-7901 | Activity | nan | None | 10.1021/np4002042 |
| Micrococcus | Micrococcus | Activity | nan | None | 10.1021/np4002042 |
| Micrococcus luteus | Micrococcus luteus | Activity | nan | None | 10.1021/np4002042 |
| Micrococcus luteus | Micrococcus luteus | MIC | 100.0 | ug.mL-1 | 10.1021/np500683u |
| Proteus hauseri | Proteus hauseri | MIC | 100.0 | ug.mL-1 | 10.1021/np500683u |
| Salmonella enterica subsp. enterica serovar Typhimurium | Salmonella typhimurium | MIC | 100.0 | ug.mL-1 | 10.1021/np500683u |
| Staphylococcus | Staphylococcus | MIC | 50000.0 | nM | 10.1021/np4002042 |
| Staphylococcus aureus | Staphylococcus aureus | Activity | nan | None | 10.1021/np4002042 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 100.0 | ug.mL-1 | 10.1021/np500683u |
| Vibrio anguillarum | Vibrio anguillarum | Activity | nan | None | 10.1021/np4002042 |
| Vibrio parahaemolyticus | Vibrio parahaemolyticus | MIC | 50000.0 | nM | 10.1021/np4002042 |
| None | NON-PROTEIN TARGET | Activity | nan | None | 10.1021/np4002042 |
| None | Unchecked | IC50 | 20220.0 | nM | 10.1021/np500683u |
| None | Unchecked | Inhibition | nan | % | 10.1021/np500683u |