Joro spider toxin-4
AlkaPlorer ID: AK101396
Synonym: 'succinamide', 'Joro spider toxin 4', '(S)-N1-(5-((S)-5-Amino-2-((S)-2-amino-5-guanidinopentanamido)pentanamido)pentyl)-2-(2-(2,4-dihydroxyphenyl)acetamido)', 'JSTX-4', 'Jorotoxin 4', 'JSTX 4'
IUPAC Name: (2S)-N-[5-[[(2S)-5-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]pentanoyl]amino]pentyl]-2-[[2-(2,4-dihydroxyphenyl)acetyl]amino]butanediamide
Structure
SMILES: N=C(N)NCCC[C@H](N)C(=O)N[C@@H](CCCN)C(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)CC1=CC=C(O)C=C1O
InChI: InChI=1S/C28H48N10O7/c29-10-4-7-20(38-25(43)19(30)6-5-13-36-28(32)33)26(44)34-11-2-1-3-12-35-27(45)21(16-23(31)41)37-24(42)14-17-8-9-18(39)15-22(17)40/h8-9,15,19-21,39-40H,1-7,10-14,16,29-30H2,(H2,31,41)(H,34,44)(H,35,45)(H,37,42)(H,38,43)(H4,32,33,36)/t19-,20-,21-/m0/s1
InChIKey: CRZSEQMZZYKNLU-ACRUOGEOSA-N
Reference
Solid-Phase Synthesis and Biological Evaluation of Joro Spider Toxin-4 from <i>Nephila clavata</i>
PubChem CID: 52937076
LOTUS: LTS0150162
NPASS: NPC326241
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 636.7550000000003
TPSA？: 313.89000000000004
MolLogP？: -2.782530000000001
Number of H-Donors: 12
Number of H-Acceptors: 10
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Rattus norvegicus | Glutamate NMDA receptor; Grin1/Grin2a | Inhibition | 25.0 | % | 10.1021/np100746w |
| Rattus norvegicus | Glutamate receptor ionotropic, AMPA 1 | Inhibition | 25.0 | % | 10.1021/np100746w |