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Melittin

AlkaPlorer ID: AK101920

Synonym: None

IUPAC Name: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[[(2S)-1-[(2S)-2-[[2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[(2-amino-1-hydroxyethylidene)amino]-1-hydroxy-3-methylpentylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1-hydroxy-3-methylbutylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-1-hydroxyhexylidene]amino]-1-hydroxy-3-methylbutylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-1,3-dihydroxybutylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxyethylidene]amino]-4-methylpentanoyl]pyrrolidin-2-yl]-hydroxymethylidene]amino]-1-hydroxypropylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-1-hydroxy-3-methylpentylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-(1H-indol-3-yl)propylidene]amino]-1-hydroxy-3-methylpentylidene]amino]-1-hydroxyhexylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxyhexylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]pentanediimidic acid

Structure

SMILES: CC[C@H](C)[C@H](N=C(O)CN)C(O)=NCC(O)=N[C@@H](C)C(O)=N[C@H](C(O)=N[C@@H](CC(C)C)C(O)=N[C@@H](CCCCN)C(O)=N[C@H](C(O)=N[C@@H](CC(C)C)C(O)=N[C@H](C(O)=N[C@H](C(O)=NCC(O)=N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=N[C@@H](C)C(O)=N[C@@H](CC(C)C)C(O)=N[C@H](C(O)=N[C@@H](CO)C(O)=N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=N[C@H](C(O)=N[C@@H](CCCCN)C(O)=N[C@@H](CCCNC(=N)N)C(O)=N[C@@H](CCCCN)C(O)=N[C@@H](CCCNC(=N)N)C(O)=N[C@@H](CCC(=N)O)C(O)=N[C@@H](CCC(=N)O)C(=N)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C

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InChI: InChI=1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)/t71-,72-,73-,74-,75-,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,100-,101-,102-,103-,104-,105-,106-/m0/s1

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InChIKey: VDXZNPDIRNWWCW-JFTDCZMZSA-N

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Reference

PubChem CID: 16133648

CAS: 20449-79-0

NPASS: NPC320968

Properties Information

Molecule Weight: 2846.514999999995

TPSA？: 1239.07

MolLogP？: 14.23344999999998

Number of H-Donors: 44

Number of H-Acceptors: 37

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii Activity nan None 10.1021/acs.jmedchem.9b01846
Acinetobacter baumannii Acinetobacter baumannii MBC 2.0 ug ml-1 10.1074/jbc.m608920200
Acinetobacter baumannii Acinetobacter baumannii MBC>99.9 1.0 uM 10.1021/acs.jmedchem.8b01348
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.9b01846
Acinetobacter baumannii Acinetobacter baumannii MIC 2.0 ug.mL-1 10.1074/jbc.m608920200
Acinetobacter baumannii Acinetobacter baumannii MIC 3.125 ug.mL-1 10.1021/acs.jmedchem.0c02059
Acinetobacter baumannii Acinetobacter baumannii MIC 3.125 ug.mL-1 10.1021/acs.jmedchem.2c01604
Acinetobacter baumannii Acinetobacter baumannii MIC 2000.0 nM 10.1021/acs.jmedchem.1c00614
Acinetobacter baumannii Acinetobacter baumannii MIC 2000.0 nM 10.1021/acs.jmedchem.9b00288
Acinetobacter baumannii Acinetobacter baumannii MIC50 4.0 ug.mL-1 10.1021/acs.jmedchem.9b01846
Acinetobacter baumannii Acinetobacter baumannii MIC>95 1.0 uM 10.1021/acs.jmedchem.8b01348
Aeromonas caviae Aeromonas caviae MIC 100000.0 nM 10.1021/jm3009037
Aspergillus fumigatus Aspergillus fumigatus Activity nan None 10.1021/jm2014474
Bacillus cereus Bacillus cereus MIC 1410.0 nM 10.1021/acs.jmedchem.6b00922
Bacillus pumilus Bacillus pumilus MIC 350.0 nM 10.1021/acs.jmedchem.6b00922
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Potency 35481.3 nM None
Bacillus subtilis Bacillus subtilis MBC 1.1 uM 10.1021/acs.jmedchem.0c00077
Bacillus subtilis Bacillus subtilis MIC 4.0 ug.mL-1 10.1016/j.ejmech.2013.07.008
Bacillus subtilis Bacillus subtilis MIC 8.0 ug.mL-1 10.1016/j.ejmech.2013.07.008
Bacillus subtilis Bacillus subtilis MIC 800.0 nM 10.1021/acs.jmedchem.0c00077
Bacillus subtilis Bacillus subtilis MIC 1000.0 nM 10.1016/j.ejmech.2019.111623
Bacillus subtilis Bacillus subtilis MIC 1000.0 nM 10.1016/j.ejmech.2020.113138
Bacillus subtilis Bacillus subtilis MIC 1000.0 nM 10.1021/acs.jmedchem.1c00614
Bacillus subtilis Bacillus subtilis MIC 1500.0 nM 10.1016/j.ejmech.2019.06.080
Bacillus subtilis Bacillus subtilis MIC 2000.0 nM 10.1021/acs.jmedchem.1c02140
Bacillus subtilis Bacillus subtilis MIC100 4.0 uM 10.1016/j.ejmech.2020.112580
Bacillus subtilis Bacillus subtilis MIC100 8.0 ug ml-1 10.1016/j.ejmech.2020.112233
Bacteria Bacteria MIC 2380.0 nM 10.1021/acs.jmedchem.1c00614
Bacteria Bacteria MIC 4000.0 nM 10.1021/acs.jmedchem.1c00614
Bacteria Bacteria MIC 6730.0 nM 10.1021/acs.jmedchem.1c00614
Bacteria Bacteria MIC100 16.0 uM 10.1016/j.ejmech.2020.112580
Bacteria Bacteria MIC100 17.2 uM 10.1016/j.ejmech.2020.112580
Bacteria Cell membrane Activity 36.03 % 10.1021/acs.jmedchem.1c01809
Bacteria Cell membrane Activity 63.97 % 10.1021/acs.jmedchem.1c01809
Bacteria Cell membrane Activity 71.88 % 10.1016/j.ejmech.2020.112580
Bacteria Cell membrane Activity 91.9 % 10.1016/j.ejmech.2020.113138
Bacteria Cell membrane Activity 92.5 % 10.1016/j.ejmech.2020.113138
Bacteria Cell membrane Activity nan None 10.1016/j.ejmech.2020.112580
Bacteria Cell membrane Activity nan None 10.1016/j.ejmech.2020.113138
Bacteria Cell membrane Activity nan None 10.1021/acs.jmedchem.0c00583
Bacteria Cell membrane Activity nan None 10.1021/acs.jmedchem.0c01506
Bacteria Cell membrane Activity nan None 10.1021/acs.jmedchem.1c00614
Bacteria Cell membrane Activity nan None 10.1021/acs.jmedchem.1c01809
Bacteria Cell membrane Activity nan None 10.1021/acs.jmedchem.2c01674
Bacteria Cell membrane Activity nan None 10.1021/acs.jmedchem.6b00922
Bacteria Lipopolysaccharide (LPS) Activity 96.0 % 10.1021/acs.jmedchem.9b00149
Bacteria Lipopolysaccharide (LPS) Activity nan None 10.1016/j.ejmech.2020.113138
Bacteria Lipopolysaccharide (LPS) Activity nan None 10.1021/acs.jmedchem.6b01457
Bacteria Lipopolysaccharide (LPS) Activity nan None 10.1021/acs.jmedchem.9b00149
Bacteria Lipopolysaccharide (LPS) Activity nan None 10.1021/acs.jmedchem.9b00288
Bordetella bronchiseptica Bordetella bronchiseptica MBC 4.0 ug ml-1 10.1074/jbc.m608920200
Bordetella bronchiseptica Bordetella bronchiseptica MIC 4.0 ug.mL-1 10.1074/jbc.m608920200
Bos taurus Serum T1/2 0.06 hr 10.1021/jm3009037
Brucella abortus Brucella abortus MBC 4.0 ug ml-1 10.1074/jbc.m608920200
Brucella abortus Brucella abortus MIC 4.0 ug.mL-1 10.1074/jbc.m608920200
Candida albicans Candida albicans Activity nan None 10.1021/acs.jmedchem.7b01729
Candida albicans Candida albicans Activity nan None 10.1021/acs.jmedchem.9b00149
Candida albicans Candida albicans MBC 1.6 uM 10.1021/acs.jmedchem.0c00077
Candida albicans Candida albicans MFC<=99.9 8.0 uM 10.1021/acs.jmedchem.9b00149
Candida albicans Candida albicans MFC99.9 2.0 uM 10.1021/acs.jmedchem.7b01729
Candida albicans Candida albicans MFC99.9 4.0 uM 10.1021/acs.jmedchem.7b01729
Candida albicans Candida albicans MFC99.9 8.0 uM 10.1021/acs.jmedchem.7b01729
Candida albicans Candida albicans MIC 1.56 ug.mL-1 10.1016/j.bmcl.2003.12.085
Candida albicans Candida albicans MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.9b01846
Candida albicans Candida albicans MIC 1600.0 nM 10.1021/acs.jmedchem.0c00077
Candida albicans Candida albicans MIC 2810.0 nM 10.1021/acs.jmedchem.6b00922
Candida albicans Candida albicans MIC 4000.0 nM 10.1021/acs.jmedchem.7b01729
Candida albicans Candida albicans MIC 8000.0 nM 10.1021/acs.jmedchem.7b01729
Candida albicans Candida albicans MIC 32000.0 nM 10.1021/acs.jmedchem.7b01729
Candida albicans Candida albicans MIC 64000.0 nM 10.1021/acs.jmedchem.7b01729
Candida albicans Candida albicans MIC100 16.0 uM 10.1016/j.ejmech.2020.112580
Candida albicans Candida albicans MIC50 4.0 ug.mL-1 10.1021/acs.jmedchem.9b01846
Candida albicans Candida albicans MIC95 2.0 uM 10.1021/acs.jmedchem.7b01729
Candida albicans Candida albicans MIC95 4.0 uM 10.1021/acs.jmedchem.7b01729
Candida albicans Candida albicans MIC95 4.0 uM 10.1021/acs.jmedchem.9b00149
Candida albicans Candida albicans MIC95 8.0 uM 10.1021/acs.jmedchem.7b01729
Candida albicans Candida albicans MIC95 8.0 uM 10.1021/acs.jmedchem.9b00149
Candida parapsilosis Candida parapsilosis MFC<=99.9 4.0 uM 10.1021/acs.jmedchem.9b00149
Candida parapsilosis Candida parapsilosis MFC99.9 2.0 uM 10.1021/acs.jmedchem.7b01729
Candida parapsilosis Candida parapsilosis MIC95 2.0 uM 10.1021/acs.jmedchem.7b01729
Candida parapsilosis Candida parapsilosis MIC95 2.0 uM 10.1021/acs.jmedchem.9b00149
Candida tropicalis Candida tropicalis MFC<=99.9 4.0 uM 10.1021/acs.jmedchem.9b00149
Candida tropicalis Candida tropicalis MFC99.9 8.0 uM 10.1021/acs.jmedchem.7b01729
Candida tropicalis Candida tropicalis MIC95 4.0 uM 10.1021/acs.jmedchem.7b01729
Candida tropicalis Candida tropicalis MIC95 4.0 uM 10.1021/acs.jmedchem.9b00149
Chlamydia trachomatis Chlamydia trachomatis MIC90 2000.0 nM 10.1016/j.ejmech.2019.06.080
Enterobacteriaceae Enterobacteriaceae MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.9b01846
Enterobacteriaceae Enterobacteriaceae MIC50 8.0 ug.mL-1 10.1021/acs.jmedchem.9b01846
Enterococcus Enterococcus MIC 0.5 ug.mL-1 10.1021/acs.jmedchem.9b01846
Enterococcus Enterococcus MIC50 4.0 ug.mL-1 10.1021/acs.jmedchem.9b01846
Enterococcus faecalis Enterococcus faecalis Activity nan None 10.1021/acs.jmedchem.9b01846
Enterococcus faecalis Enterococcus faecalis log(activity) 5.0 None 10.1021/acs.jmedchem.9b01846
Enterococcus faecalis Enterococcus faecalis MBC 1.6 uM 10.1021/acs.jmedchem.0c00077
Enterococcus faecalis Enterococcus faecalis MIC 1600.0 nM 10.1021/acs.jmedchem.0c00077
Enterococcus faecalis Enterococcus faecalis MIC 2000.0 nM 10.1021/acs.jmedchem.0c00583
Enterococcus faecalis Enterococcus faecalis MIC 2000.0 nM 10.1021/acs.jmedchem.1c02140
Enterococcus faecalis Enterococcus faecalis MIC 4000.0 nM 10.1021/acs.jmedchem.1c00614
Enterococcus faecalis Enterococcus faecalis MIC 12500.0 nM 10.1021/jm3009037
Enterococcus faecium Enterococcus faecium MIC 2000.0 nM 10.1016/j.ejmech.2019.111804
Enterococcus faecium Enterococcus faecium MIC 8000.0 nM 10.1016/j.ejmech.2019.111623
Enterococcus faecium Enterococcus faecium MIC 16000.0 nM 10.1016/j.ejmech.2017.05.028
Enterococcus faecium Enterococcus faecium MIC100 16.0 ug ml-1 10.1016/j.ejmech.2016.09.071
Enterococcus faecium Enterococcus faecium MIC100 16.0 uM 10.1016/j.ejmech.2020.112580
Escherichia coli Escherichia coli Activity 55.5 % 10.1021/acs.jmedchem.8b01135
Escherichia coli Escherichia coli Activity 75.38 % 10.1016/j.ejmech.2019.111623
Escherichia coli Escherichia coli Activity nan None 10.1016/j.ejmech.2016.09.071
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.0c00583
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.1c00614
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.7b01831
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.9b00149
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jmedchem.9b01846
Escherichia coli Escherichia coli Activity nan None 10.1128/aac.00380-10
Escherichia coli Escherichia coli FC 8.0 None 10.1016/j.bmcl.2013.12.023
Escherichia coli Escherichia coli Flu intensity 4000.0 a.u. 10.1021/acs.jmedchem.9b00149
Escherichia coli Escherichia coli GI nan None 10.1016/j.bmcl.2013.06.016
Escherichia coli Escherichia coli GI nan None 10.1016/j.ejmech.2013.07.008
Escherichia coli Escherichia coli Inhibition nan % 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli MBC 4.0 ug ml-1 10.1074/jbc.m608920200
Escherichia coli Escherichia coli MBC 4.7 uM 10.1021/acs.jmedchem.0c00077
Escherichia coli Escherichia coli MBC 12.5 ug ml-1 10.1074/jbc.m608920200
Escherichia coli Escherichia coli MBC=>99.9 20.0 uM 10.1021/acs.jmedchem.7b01831
Escherichia coli Escherichia coli MBC>99.9 1.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MBC>99.9 2.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MBC>99.9 2.0 uM 10.1021/acs.jmedchem.9b00149
Escherichia coli Escherichia coli MBC>99.9 4.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MBC>99.9 4.0 uM 10.1021/acs.jmedchem.9b00149
Escherichia coli Escherichia coli MBC>99.9 8.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MBC>99.9 16.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MBC>99.9 32.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MBC>99.9 64.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MBC99.9 2.0 uM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.6b01457
Escherichia coli Escherichia coli MIC 2.0 ug.mL-1 10.1128/aac.00530-10
Escherichia coli Escherichia coli MIC 3.12 ug.mL-1 10.1016/j.bmcl.2003.12.085
Escherichia coli Escherichia coli MIC 3.125 ug.mL-1 10.1021/acs.jmedchem.0c02059
Escherichia coli Escherichia coli MIC 3.125 ug.mL-1 10.1021/acs.jmedchem.2c01604
Escherichia coli Escherichia coli MIC 4.0 ug.mL-1 10.1074/jbc.m608920200
Escherichia coli Escherichia coli MIC 8.0 ug.mL-1 10.1016/j.ejmech.2013.07.008
Escherichia coli Escherichia coli MIC 12.5 ug.mL-1 10.1074/jbc.m608920200
Escherichia coli Escherichia coli MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.2c00123
Escherichia coli Escherichia coli MIC 350.0 nM 10.1021/acs.jmedchem.6b00922
Escherichia coli Escherichia coli MIC 1000.0 nM 10.1021/acs.jmedchem.1c01485
Escherichia coli Escherichia coli MIC 1410.0 nM 10.1021/acs.jmedchem.6b00922
Escherichia coli Escherichia coli MIC 2000.0 nM 10.1021/acs.jmedchem.0c00583
Escherichia coli Escherichia coli MIC 2000.0 nM 10.1021/acs.jmedchem.1c01485
Escherichia coli Escherichia coli MIC 2000.0 nM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MIC 2000.0 nM 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli MIC 3000.0 nM 10.1021/jm9509410
Escherichia coli Escherichia coli MIC 3400.0 nM 10.1021/acs.jmedchem.0c00077
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1016/j.ejmech.2019.111623
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1021/acs.jmedchem.0c00583
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MIC 4000.0 nM 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli MIC 4600.0 nM 10.1016/j.bmcl.2013.12.023
Escherichia coli Escherichia coli MIC 5700.0 nM 10.1016/j.ejmech.2019.06.080
Escherichia coli Escherichia coli MIC 6250.0 nM 10.1021/jm3009037
Escherichia coli Escherichia coli MIC 8000.0 nM 10.1021/acs.jmedchem.0c00583
Escherichia coli Escherichia coli MIC 8000.0 nM 10.1021/acs.jmedchem.1c00614
Escherichia coli Escherichia coli MIC 8000.0 nM 10.1021/acs.jmedchem.1c02140
Escherichia coli Escherichia coli MIC 8000.0 nM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MIC 8000.0 nM 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli MIC 8000.0 nM 10.1021/jf0718143
Escherichia coli Escherichia coli MIC 10000.0 nM 10.1021/acs.jmedchem.7b01831
Escherichia coli Escherichia coli MIC 32000.0 nM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MIC 32000.0 nM 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli MIC 64000.0 nM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MIC 64000.0 nM 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli MIC100 16.0 ug ml-1 10.1016/j.ejmech.2016.09.071
Escherichia coli Escherichia coli MIC100 16.0 ug ml-1 10.1016/j.ejmech.2020.112233
Escherichia coli Escherichia coli MIC100 16.0 uM 10.1016/j.ejmech.2020.112580
Escherichia coli Escherichia coli MIC>95 0.5 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MIC>95 1.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MIC>95 2.0 uM 10.1021/acs.jmedchem.8b01348
Escherichia coli Escherichia coli MIC95 1.0 uM 10.1021/acs.jmedchem.9b00149
Escherichia coli Escherichia coli MIC95 2.0 uM 10.1021/acs.jmedchem.7b01729
Escherichia coli Escherichia coli MIC95 2.0 uM 10.1021/acs.jmedchem.9b00149
Escherichia coli Escherichia coli MIC95 4.0 uM 10.1021/acs.jmedchem.9b00149
Escherichia coli Escherichia coli MIC95 8.0 uM 10.1021/acs.jmedchem.9b00149
Escherichia coli Escherichia coli Ratio 4.0 None 10.1021/acs.jmedchem.9b00288
Escherichia coli Escherichia coli TIME 4.0 hr 10.1021/acs.jmedchem.0c01506
Fungi Fungi MIC 4000.0 nM 10.1021/acs.jmedchem.1c00614
Homo sapiens 78 kDa glucose-regulated protein Potency 15848.9 nM None
Homo sapiens Blood HC10 2.7 ug ml-1 10.1016/j.bmcl.2021.127853
Homo sapiens Blood HC50 8.5 ug ml-1 10.1016/j.bmcl.2021.127853
Homo sapiens Caco-2 IC50 4500.0 nM 10.1021/jm401335p
Homo sapiens Chymotrypsin Stability nan % 10.1021/acs.jmedchem.8b01348
Homo sapiens c-Jun N-terminal kinase, JNK Inhibition nan % 10.1021/np300446c
Homo sapiens HEK-293T Activity nan None 10.1016/j.ejmech.2020.113138
Homo sapiens HEK-293T Activity nan None 10.1021/acs.jmedchem.0c00583
Homo sapiens HEK-293T IC50 2484.0 nM 10.1021/acs.jmedchem.8b01348
Homo sapiens HeLa Activity 86.0 % 10.1074/jbc.m608920200
Homo sapiens HeLa Activity 90.1 % 10.1074/jbc.m608920200
Homo sapiens HeLa IC50 1900.0 nM 10.1021/jm401335p
Homo sapiens HepG2 IC50 2500.0 nM 10.1021/jm401335p
Homo sapiens HFF-1 IC50 nan None 10.1021/acs.jnatprod.8b00572
Homo sapiens Homo sapiens Concentration 1.0 uM 10.1021/jm9509410
Homo sapiens HT-29 IC50 nan None 10.1021/acs.jnatprod.8b00572
Homo sapiens HUVEC Activity 96.5 % 10.1021/np300446c
Homo sapiens HUVEC Activity 98.5 % 10.1021/np300446c
Homo sapiens HUVEC Activity 98.9 % 10.1021/np300446c
Homo sapiens HUVEC Activity 99.4 % 10.1021/np300446c
Homo sapiens HUVEC Activity 103.8 % 10.1021/np300446c
Homo sapiens HUVEC Activity nan None 10.1021/np300446c
Homo sapiens HUVEC IC50 13000.0 nM 10.1021/np300446c
Homo sapiens HUVEC IC50 18000.0 nM 10.1021/np300446c
Homo sapiens HUVEC IC50 nan None 10.1021/acs.jnatprod.8b00572
Homo sapiens HUVEC IC50 nan None 10.1021/jm401335p
Homo sapiens HUVEC Inhibition nan % 10.1021/np300446c
Homo sapiens MAP kinase p38 Activity nan None 10.1021/np300446c
Homo sapiens MDA-MB-231 IC50 nan None 10.1021/acs.jnatprod.8b00572
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
Homo sapiens Mitogen-activated protein kinase; ERK1/ERK2 Inhibition nan % 10.1021/np300446c
Homo sapiens MM96L IC50 nan None 10.1021/acs.jnatprod.8b00572
Homo sapiens NHDF Activity nan None 10.1021/acs.jmedchem.9b01846
Homo sapiens NHDF MCC 8.0 ug.mL-1 10.1021/acs.jmedchem.9b01846
Homo sapiens PBMC Activity nan None 10.1021/np200722w
Homo sapiens Trypsin Stability nan % 10.1021/acs.jmedchem.0c00583
Homo sapiens Trypsin Stability nan % 10.1021/acs.jmedchem.8b01348
Klebsiella aerogenes Klebsiella aerogenes MIC 12500.0 nM 10.1021/jm3009037
Klebsiella oxytoca Klebsiella oxytoca MIC 25000.0 nM 10.1021/jm3009037
Klebsiella pneumoniae Klebsiella pneumoniae Activity nan None 10.1021/acs.jmedchem.1c00614
Klebsiella pneumoniae Klebsiella pneumoniae Activity nan None 10.1021/acs.jmedchem.9b01846
Klebsiella pneumoniae Klebsiella pneumoniae MBC>99.9 2.0 uM 10.1021/acs.jmedchem.8b01348
Klebsiella pneumoniae Klebsiella pneumoniae MIC 6.25 ug.mL-1 10.1021/acs.jmedchem.0c02059
Klebsiella pneumoniae Klebsiella pneumoniae MIC 6.25 ug.mL-1 10.1021/acs.jmedchem.2c01604
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16000.0 nM 10.1021/acs.jmedchem.1c00614
Klebsiella pneumoniae Klebsiella pneumoniae MIC 16000.0 nM 10.1021/acs.jmedchem.1c02140
Klebsiella pneumoniae Klebsiella pneumoniae MIC>95 2.0 uM 10.1021/acs.jmedchem.8b01348
Listeria monocytogenes Listeria monocytogenes Activity nan None 10.1128/aac.00635-07
Listeria monocytogenes Listeria monocytogenes MIC 180.0 nM 10.1021/acs.jmedchem.6b00922
Listeria monocytogenes Listeria monocytogenes MIC 350.0 nM 10.1021/acs.jmedchem.6b00922
Listeria monocytogenes Listeria monocytogenes MIC 3120.0 nM 10.1021/jm3009037
Micrococcus luteus Micrococcus luteus MIC 700.0 nM 10.1021/acs.jmedchem.6b00922
Micrococcus luteus Micrococcus luteus MIC 1560.0 nM 10.1021/jm3009037
Mus musculus J774.A1 Activity nan None 10.1021/acs.jmedchem.7b00355
Mus musculus Lewis lung carcinoma cell line Activity 52.0 % 10.1021/np300446c
Mus musculus Lewis lung carcinoma cell line Activity 59.0 % 10.1021/np300446c
Mus musculus Lewis lung carcinoma cell line Activity 60.0 % 10.1021/np300446c
Mus musculus Lewis lung carcinoma cell line Activity 91.0 % 10.1021/np300446c
Mus musculus Lewis lung carcinoma cell line TGI 25.0 % 10.1021/np300446c
Mus musculus Lewis lung carcinoma cell line TGI 57.0 % 10.1021/np300446c
Mus musculus Mus musculus Activity nan None 10.1021/np300446c
Mus musculus Mus musculus Concentration 1.0 uM 10.1021/jm9509410
Mus musculus Mus musculus HD50 nan None 10.1016/j.bmcl.2003.12.085
Mus musculus NIH3T3 Activity nan None 10.1016/j.ejmech.2020.112580
Mus musculus Nuclear receptor ROR-gamma Potency 2818.4 nM None
Mus musculus Nuclear receptor ROR-gamma Potency 5011.9 nM None
Mus musculus RAW264.7 Activity 1.85 % 10.1021/acs.jmedchem.6b00922
Mus musculus RAW264.7 Activity 100.0 % 10.1021/acs.jmedchem.8b01135
Mus musculus RAW264.7 Activity nan None 10.1016/j.ejmech.2020.112580
Mus musculus RAW264.7 Activity nan None 10.1021/acs.jmedchem.0c00583
Mus musculus RAW264.7 Activity nan None 10.1021/acs.jmedchem.9b00149
Mus musculus RAW264.7 CC10 0.5 mg/L 10.1021/acs.jmedchem.6b01457
Mus musculus RAW264.7 IC50 1300.0 nM 10.1021/acs.jmedchem.1c01485
Mus musculus RAW264.7 IC50 1940.0 nM 10.1021/acs.jmedchem.1c01485
Mus musculus RAW264.7 IC50 2094.0 nM 10.1021/acs.jmedchem.8b01348
Mus musculus RAW264.7 Inhibition 10.0 % 10.1016/j.ejmech.2020.112580
Penicillium digitatum Penicillium digitatum Inhibition nan % 10.1021/jf0718143
Penicillium digitatum Penicillium digitatum MIC 2000.0 nM 10.1021/jf0718143
Pichia kudriavzevii Pichia kudriavzevii MFC99.9 4.0 uM 10.1021/acs.jmedchem.7b01729
Pichia kudriavzevii Pichia kudriavzevii MIC95 2.0 uM 10.1021/acs.jmedchem.7b01729
Priestia megaterium Priestia megaterium MIC 6250.0 nM 10.1021/jm3009037
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1021/acs.jmedchem.1c01485
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1021/acs.jmedchem.9b00149
Pseudomonas aeruginosa Pseudomonas aeruginosa Activity nan None 10.1021/acs.jmedchem.9b00288
Pseudomonas aeruginosa Pseudomonas aeruginosa Drug uptake nan None 10.1021/acs.jmedchem.6b01457
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 3.1 uM 10.1021/acs.jmedchem.0c00077
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC 16.0 ug ml-1 10.1074/jbc.m608920200
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC>99.9 2.0 uM 10.1021/acs.jmedchem.8b01348
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC>99.9 4.0 uM 10.1021/acs.jmedchem.8b01348
Pseudomonas aeruginosa Pseudomonas aeruginosa MBC>99.9 4.0 uM 10.1021/acs.jmedchem.9b00149
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 1.56 ug.mL-1 10.1016/j.bmcl.2003.12.085
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2.0 ug.mL-1 10.1021/acs.jmedchem.6b01457
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3.125 ug.mL-1 10.1021/acs.jmedchem.0c02059
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.6b01457
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.9b01846
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6.25 ug.mL-1 10.1021/acs.jmedchem.2c01604
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1016/j.ejmech.2013.07.008
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.6b01457
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.2c00123
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.6b01457
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16.0 ug.mL-1 10.1074/jbc.m608920200
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 32.0 ug.mL-1 10.1021/acs.jmedchem.6b01457
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 64.0 ug.mL-1 10.1021/acs.jmedchem.6b01457
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2000.0 nM 10.1016/j.ejmech.2019.111623
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2000.0 nM 10.1016/j.ejmech.2019.111804
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 2000.0 nM 10.1021/acs.jmedchem.1c01485
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 3100.0 nM 10.1021/acs.jmedchem.0c00077
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4000.0 nM 10.1016/j.ejmech.2019.111804
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 4000.0 nM 10.1021/acs.jmedchem.9b00288
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 6000.0 nM 10.1021/jm9509410
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8000.0 nM 10.1016/j.ejmech.2019.111623
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8000.0 nM 10.1021/acs.jmedchem.1c00614
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 8000.0 nM 10.1021/acs.jmedchem.1c02140
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 16000.0 nM 10.1016/j.ejmech.2017.05.028
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 50000.0 nM 10.1021/jm3009037
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC100 4.0 uM 10.1016/j.ejmech.2020.112580
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC100 16.0 ug ml-1 10.1016/j.ejmech.2020.112233
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC100 32.0 ug ml-1 10.1016/j.ejmech.2016.09.071
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC50 16.0 ug.mL-1 10.1021/acs.jmedchem.9b01846
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC>95 2.0 uM 10.1021/acs.jmedchem.8b01348
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC>95 4.0 uM 10.1021/acs.jmedchem.8b01348
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC95 2.0 uM 10.1021/acs.jmedchem.9b00149
Pseudomonas aeruginosa Pseudomonas aeruginosa Ratio 128.0 None 10.1021/acs.jmedchem.9b00149
Pseudomonas aeruginosa Pseudomonas aeruginosa Ratio 256.0 None 10.1021/acs.jmedchem.8b01348
Pseudomonas fluorescens Pseudomonas fluorescens MIC 1410.0 nM 10.1021/acs.jmedchem.6b00922
Saccharomyces cerevisiae Saccharomyces cerevisiae MIC 16000.0 nM 10.1021/jf0718143
Saccharomyces cerevisiae Saccharomyces cerevisiae MIC100 16.0 uM 10.1016/j.ejmech.2020.112580
Salmonella enterica Salmonella enterica MIC 700.0 nM 10.1021/acs.jmedchem.6b00922
Salmonella enterica Salmonella enterica MIC 4000.0 nM 10.1021/acs.jmedchem.0c00583
Salmonella enterica Salmonella enterica MIC 25000.0 nM 10.1021/jm3009037
Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enteritidis MIC 1410.0 nM 10.1021/acs.jmedchem.6b00922
Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella paratyphi MIC 700.0 nM 10.1021/acs.jmedchem.6b00922
Salmonella enterica subsp. enterica serovar Paratyphi B Salmonella enterica subsp. enterica serovar Paratyphi B MIC 350.0 nM 10.1021/acs.jmedchem.6b00922
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MBC>99.9 2.0 uM 10.1021/acs.jmedchem.8b01348
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MBC>99.9 2.0 uM 10.1021/acs.jmedchem.9b00149
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MBC>99.9 4.0 uM 10.1021/acs.jmedchem.9b00149
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MBC99.9 2.0 uM 10.1021/acs.jmedchem.7b01729
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 8.0 ug.mL-1 10.1016/j.ejmech.2013.07.008
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 16.0 ug.mL-1 10.1016/j.ejmech.2013.07.008
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 1000.0 nM 10.1021/acs.jmedchem.1c01485
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 2000.0 nM 10.1016/j.ejmech.2019.111623
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 2000.0 nM 10.1021/acs.jmedchem.0c00583
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 2000.0 nM 10.1021/acs.jmedchem.1c01485
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 2000.0 nM 10.1021/acs.jmedchem.9b00288
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC 2810.0 nM 10.1021/acs.jmedchem.6b00922
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC100 2.0 uM 10.1016/j.ejmech.2020.112580
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC>95 1.0 uM 10.1021/acs.jmedchem.8b01348
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC95 1.0 uM 10.1021/acs.jmedchem.7b01729
Salmonella enterica subsp. enterica serovar Typhimurium Salmonella typhimurium MIC95 2.0 uM 10.1021/acs.jmedchem.9b00149
Shigella flexneri Shigella flexneri MIC 700.0 nM 10.1021/acs.jmedchem.6b00922
Staphylococcus aureus Staphylococcus aureus Activity 100.0 % 10.1039/C7MD00592J
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.ejmech.2016.09.054
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.ejmech.2016.09.071
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.ejmech.2017.05.028
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.ejmech.2019.111623
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1016/j.ejmech.2020.113138
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jmedchem.0c00583
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jmedchem.1c00614
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jmedchem.8b01135
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jmedchem.9b00149
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jnatprod.2c00621
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jnatprod.9b00064
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1039/C8MD00257F
Staphylococcus aureus Staphylococcus aureus ED50 0.2 uM 10.1039/C7MD00592J
Staphylococcus aureus Staphylococcus aureus GI nan None 10.1016/j.bmcl.2013.06.016
Staphylococcus aureus Staphylococcus aureus GI nan None 10.1016/j.ejmech.2013.07.008
Staphylococcus aureus Staphylococcus aureus LC50 200.0 nM 10.1039/C7MD00592J
Staphylococcus aureus Staphylococcus aureus MBC 1.2 uM 10.1021/acs.jmedchem.0c00077
Staphylococcus aureus Staphylococcus aureus MBC 2.0 ug ml-1 10.1074/jbc.m608920200
Staphylococcus aureus Staphylococcus aureus MBC>99.9 4.0 uM 10.1021/acs.jmedchem.9b00149
Staphylococcus aureus Staphylococcus aureus MBC>99.9 8.0 uM 10.1021/acs.jmedchem.9b00149
Staphylococcus aureus Staphylococcus aureus MBC99.9 1.0 uM 10.1021/acs.jmedchem.7b01729
Staphylococcus aureus Staphylococcus aureus MBC99.9 4.0 uM 10.1021/acs.jmedchem.7b01729
Staphylococcus aureus Staphylococcus aureus MBC99.9 8.0 uM 10.1021/acs.jmedchem.7b01729
Staphylococcus aureus Staphylococcus aureus MIC 0.5 ug.mL-1 10.1128/aac.00530-10
Staphylococcus aureus Staphylococcus aureus MIC 1.25 ug.mL-1 10.1016/j.ejmech.2016.09.054
Staphylococcus aureus Staphylococcus aureus MIC 1.25 ug.mL-1 10.1021/acs.jnatprod.9b00064
Staphylococcus aureus Staphylococcus aureus MIC 1.56 ug.mL-1 10.1021/acs.jmedchem.2c01604
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1016/j.ejmech.2013.07.008
Staphylococcus aureus Staphylococcus aureus MIC 2.0 ug.mL-1 10.1074/jbc.m608920200
Staphylococcus aureus Staphylococcus aureus MIC 3.12 ug.mL-1 10.1016/j.bmcl.2003.12.085
Staphylococcus aureus Staphylococcus aureus MIC 3.125 ug.mL-1 10.1021/acs.jmedchem.0c02059
Staphylococcus aureus Staphylococcus aureus MIC 3.125 ug.mL-1 10.1021/acs.jmedchem.2c01604
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1016/j.ejmech.2013.07.008
Staphylococcus aureus Staphylococcus aureus MIC 4.0 ug.mL-1 10.1021/acs.jmedchem.9b01846
Staphylococcus aureus Staphylococcus aureus MIC 8.0 ug.mL-1 10.1021/acs.jmedchem.6b01457
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1016/j.ejmech.2020.112233
Staphylococcus aureus Staphylococcus aureus MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.2c00123
Staphylococcus aureus Staphylococcus aureus MIC 900.0 nM 10.1021/acs.jmedchem.0c00077
Staphylococcus aureus Staphylococcus aureus MIC 1410.0 nM 10.1021/acs.jmedchem.6b00922
Staphylococcus aureus Staphylococcus aureus MIC 2000.0 nM 10.1016/j.ejmech.2019.111623
Staphylococcus aureus Staphylococcus aureus MIC 2000.0 nM 10.1016/j.ejmech.2019.111804
Staphylococcus aureus Staphylococcus aureus MIC 2000.0 nM 10.1016/j.ejmech.2020.113138
Staphylococcus aureus Staphylococcus aureus MIC 2000.0 nM 10.1021/acs.jmedchem.0c00583
Staphylococcus aureus Staphylococcus aureus MIC 2000.0 nM 10.1021/acs.jmedchem.1c00614
Staphylococcus aureus Staphylococcus aureus MIC 2000.0 nM 10.1021/acs.jmedchem.1c01485
Staphylococcus aureus Staphylococcus aureus MIC 2000.0 nM 10.1021/acs.jmedchem.9b00288
Staphylococcus aureus Staphylococcus aureus MIC 2100.0 nM 10.1016/j.bmcl.2013.12.023
Staphylococcus aureus Staphylococcus aureus MIC 2810.0 nM 10.1021/acs.jmedchem.6b00922
Staphylococcus aureus Staphylococcus aureus MIC 3000.0 nM 10.1021/jm9509410
Staphylococcus aureus Staphylococcus aureus MIC 4000.0 nM 10.1016/j.ejmech.2019.111623
Staphylococcus aureus Staphylococcus aureus MIC 4000.0 nM 10.1016/j.ejmech.2019.111804
Staphylococcus aureus Staphylococcus aureus MIC 4000.0 nM 10.1016/j.ejmech.2020.113138
Staphylococcus aureus Staphylococcus aureus MIC 4000.0 nM 10.1021/acs.jmedchem.0c00583
Staphylococcus aureus Staphylococcus aureus MIC 4000.0 nM 10.1021/acs.jmedchem.1c01485
Staphylococcus aureus Staphylococcus aureus MIC 8000.0 nM 10.1016/j.ejmech.2017.05.028
Staphylococcus aureus Staphylococcus aureus MIC 8000.0 nM 10.1016/j.ejmech.2020.113138
Staphylococcus aureus Staphylococcus aureus MIC 8000.0 nM 10.1021/acs.jmedchem.0c00583
Staphylococcus aureus Staphylococcus aureus MIC 8000.0 nM 10.1021/acs.jmedchem.1c01485
Staphylococcus aureus Staphylococcus aureus MIC 8000.0 nM 10.1021/acs.jmedchem.1c02140
Staphylococcus aureus Staphylococcus aureus MIC 8000.0 nM 10.1021/acs.jmedchem.9b00288
Staphylococcus aureus Staphylococcus aureus MIC 16000.0 nM 10.1016/j.ejmech.2019.111623
Staphylococcus aureus Staphylococcus aureus MIC 16000.0 nM 10.1021/acs.jmedchem.9b00288
Staphylococcus aureus Staphylococcus aureus MIC 25000.0 nM 10.1021/jm3009037
Staphylococcus aureus Staphylococcus aureus MIC100 4.0 uM 10.1016/j.ejmech.2020.112580
Staphylococcus aureus Staphylococcus aureus MIC100 8.0 ug ml-1 10.1016/j.ejmech.2020.112233
Staphylococcus aureus Staphylococcus aureus MIC100 16.0 ug ml-1 10.1016/j.ejmech.2016.09.071
Staphylococcus aureus Staphylococcus aureus MIC100 16.0 uM 10.1016/j.ejmech.2020.112580
Staphylococcus aureus Staphylococcus aureus MIC100 32.0 uM 10.1016/j.ejmech.2020.112580
Staphylococcus aureus Staphylococcus aureus MIC50 4.0 ug.mL-1 10.1021/acs.jmedchem.9b01846
Staphylococcus aureus Staphylococcus aureus MIC95 1.0 uM 10.1021/acs.jmedchem.7b01729
Staphylococcus aureus Staphylococcus aureus MIC95 1.0 uM 10.1021/acs.jmedchem.9b00149
Staphylococcus aureus Staphylococcus aureus MIC95 4.0 uM 10.1021/acs.jmedchem.7b01729
Staphylococcus aureus Staphylococcus aureus MIC95 4.0 uM 10.1021/acs.jmedchem.9b00149
Staphylococcus aureus Staphylococcus aureus MIC95 8.0 uM 10.1021/acs.jmedchem.7b01729
Staphylococcus aureus Staphylococcus aureus MIC95 8.0 uM 10.1021/acs.jmedchem.9b00149
Staphylococcus aureus Staphylococcus aureus Ratio 2.0 None 10.1016/j.ejmech.2020.113138
Staphylococcus epidermidis Staphylococcus epidermidis Activity nan None 10.1016/j.ejmech.2020.113138
Staphylococcus epidermidis Staphylococcus epidermidis MBC>99.9 4.0 uM 10.1021/acs.jmedchem.9b00149
Staphylococcus epidermidis Staphylococcus epidermidis MBC99.9 1.0 uM 10.1021/acs.jmedchem.7b01729
Staphylococcus epidermidis Staphylococcus epidermidis MIC 4.0 ug.mL-1 10.1016/j.ejmech.2013.07.008
Staphylococcus epidermidis Staphylococcus epidermidis MIC 8.0 ug.mL-1 10.1016/j.ejmech.2013.07.008
Staphylococcus epidermidis Staphylococcus epidermidis MIC 16.0 ug.mL-1 10.1021/acs.jmedchem.2c00123
Staphylococcus epidermidis Staphylococcus epidermidis MIC 500.0 nM 10.1021/acs.jmedchem.9b00288
Staphylococcus epidermidis Staphylococcus epidermidis MIC 1000.0 nM 10.1021/acs.jmedchem.1c01485
Staphylococcus epidermidis Staphylococcus epidermidis MIC 2000.0 nM 10.1021/acs.jmedchem.0c00583
Staphylococcus epidermidis Staphylococcus epidermidis MIC 2000.0 nM 10.1021/acs.jmedchem.1c01485
Staphylococcus epidermidis Staphylococcus epidermidis MIC 4000.0 nM 10.1016/j.ejmech.2019.111623
Staphylococcus epidermidis Staphylococcus epidermidis MIC 4000.0 nM 10.1016/j.ejmech.2020.113138
Staphylococcus epidermidis Staphylococcus epidermidis MIC 4000.0 nM 10.1021/acs.jmedchem.1c00614
Staphylococcus epidermidis Staphylococcus epidermidis MIC 4000.0 nM 10.1021/acs.jmedchem.1c02140
Staphylococcus epidermidis Staphylococcus epidermidis MIC100 8.0 uM 10.1016/j.ejmech.2020.112580
Staphylococcus epidermidis Staphylococcus epidermidis MIC100 32.0 ug ml-1 10.1016/j.ejmech.2016.09.071
Staphylococcus epidermidis Staphylococcus epidermidis MIC95 0.5 uM 10.1021/acs.jmedchem.7b01729
Staphylococcus epidermidis Staphylococcus epidermidis MIC95 2.0 uM 10.1021/acs.jmedchem.9b00149
Streptococcus agalactiae Streptococcus agalactiae MIC 1000.0 nM 10.1021/acs.jmedchem.0c00583
Streptococcus equinus Streptococcus equinus MIC 3120.0 nM 10.1021/jm3009037
Vibrio parahaemolyticus Vibrio parahaemolyticus MIC 1410.0 nM 10.1021/acs.jmedchem.6b00922
Yersinia pestis Yersinia pestis MBC 16.0 ug ml-1 10.1074/jbc.m608920200
Yersinia pestis Yersinia pestis MIC 16.0 ug.mL-1 10.1074/jbc.m608920200
None ADMET Activity 90.0 % 10.1016/j.bmc.2010.01.026
None ADMET Activity 100.0 % 10.1016/j.bmcl.2007.08.056
None ADMET Activity 100.0 % 10.1016/j.bmcl.2009.08.031
None ADMET Activity 100.0 % 10.1021/jm800704e
None ADMET Activity nan None 10.1016/j.bmc.2016.05.006
None ADMET Activity nan None 10.1016/j.bmcl.2013.12.023
None ADMET Activity nan None 10.1021/jf0718143
None ADMET Activity nan None 10.1021/jm501824a
None ADMET Activity nan None 10.1128/aac.00534-10
None ADMET Activity nan None 10.1128/aac.00635-07
None ADMET HC50 10.5 ug ml-1 10.1016/j.ejmech.2013.07.008
None ADMET HD50 0.6 uM 10.1021/np4009317
None ADMET HD50 0.94 uM 10.1021/np050317i
None ADMET IC50 2200.0 nM 10.1021/jm401335p
None ADMET IC50 6400.0 nM 10.1021/jm401335p
None ADMET IC50 nan None 10.1021/jm401335p
None ADMET MHC 0.78 uM 10.1128/aac.00530-10
None ADMET Ratio 0.34 None 10.1021/acs.jmedchem.1c00614
None ADMET Ratio 0.95 None 10.1021/acs.jmedchem.1c00614
None ADMET Ratio 57.0 None 10.1021/acs.jmedchem.1c00614
None ADMET Stability 85.3 % 10.1021/acs.jmedchem.9b01846
None ADMET Stability nan % 10.1021/acs.jmedchem.9b01846
None ADMET Stability nan % 10.1021/jm2014474
None ADMET TI 0.1 None 10.1016/j.ejmech.2020.112580
None ADMET TI 0.1 None 10.1021/acs.jmedchem.9b00288
None ADMET TI 0.3 None 10.1016/j.ejmech.2020.112233
None ADMET TI 0.32 None 10.1021/acs.jmedchem.9b00149
None ADMET TI 0.35 None 10.1021/acs.jmedchem.9b00149
None ADMET TI 0.4 None 10.1021/acs.jmedchem.0c00583
None ADMET TI 0.43 None 10.1021/acs.jmedchem.6b00922
None ADMET TI 0.44 None 10.1021/acs.jmedchem.6b00922
None ADMET TI 0.5 None 10.1016/j.ejmech.2016.09.071
None ADMET TI 0.54 None 10.1021/acs.jmedchem.9b00149
None ADMET TI 0.56 None 10.1021/acs.jmedchem.0c00583
None ADMET TI 0.8 None 10.1016/j.ejmech.2020.113138
None Erythrocyte Activity 5.0 % 10.1021/acs.jmedchem.0c00583
None Erythrocyte Activity 10.05 % 10.1021/acs.jmedchem.0c00583
None Erythrocyte Activity 12.0 % 10.1016/j.ejmech.2020.112233
None Erythrocyte Activity 63.0 % 10.1021/acs.jmedchem.8b01135
None Erythrocyte Activity 63.73 % 10.1021/acs.jmedchem.6b00922
None Erythrocyte Activity 84.0 % 10.1021/acs.jmedchem.9b00149
None Erythrocyte Activity 100.0 % 10.1016/j.ejmech.2019.06.080
None Erythrocyte CC50 200.0 nM 10.1021/acs.jnatprod.0c01069
None Erythrocyte HC10 0.25 uM 10.1021/acs.jmedchem.7b01729
None Erythrocyte HC10 1.0 uM 10.1016/j.ejmech.2020.112580
None Erythrocyte HC10 2.0 uM 10.1021/acs.jmedchem.8b01348
None Erythrocyte HC10 2.7 ug ml-1 10.1016/j.bmc.2019.04.004
None Erythrocyte HC10 2.7 ug ml-1 10.1016/j.bmc.2022.116762
None Erythrocyte HC10 2.7 ug ml-1 10.1016/j.ejmech.2020.112477
None Erythrocyte HC50 8.5 ug ml-1 10.1021/acsmedchemlett.0c00611
None Erythrocyte HC50 23.4 ug ml-1 10.1021/acs.jmedchem.0c02059
None Erythrocyte HD50 1.95 ug ml-1 10.1021/acs.jmedchem.9b01846
None Erythrocyte HD50 3.0 uM 10.1021/acs.jmedchem.0c00077
None Erythrocyte IC50 960.0 nM 10.1021/acs.jnatprod.8b00572
None Erythrocyte MHC 0.25 uM 10.1021/acs.jmedchem.9b00288
None Erythrocyte MHC 1.0 uM 10.1021/acs.jmedchem.0c00583
None Erythrocyte MHC 4.0 ug ml-1 10.1016/j.ejmech.2020.112233
None Erythrocyte MHC10 0.35 uM 10.1021/acs.jmedchem.6b00922
None Erythrocyte MHC10 1.0 uM 10.1021/acs.jmedchem.9b00149
None Erythrocyte MHC10 2.0 uM 10.1016/j.ejmech.2020.113138
None Erythrocyte MHC10 2.26 uM 10.1021/acs.jmedchem.1c00614
None Lipid bilayer Activity 85.0 % 10.1021/acs.jmedchem.9b00149
None Lipid bilayer Activity nan None 10.1021/acs.jmedchem.7b01729
None Lipid bilayer Activity nan None 10.1021/acs.jmedchem.9b00149
None Lipid bilayer Activity nan None 10.1021/acs.jmedchem.9b01846
None Lipid bilayer Ratio 0.04 None 10.1021/acs.jmedchem.9b01846
None NON-PROTEIN TARGET MIC 0.78 ug.mL-1 10.1016/j.bmcl.2003.12.085
None NON-PROTEIN TARGET MIC 6250.0 nM 10.1021/jm3009037
None Unchecked Activity 60.0 % 10.1021/acs.jmedchem.7b01831
None Unchecked Activity 90.0 % 10.1021/acsmedchemlett.2c00487
None Unchecked Activity 99.6 % 10.1021/acs.jmedchem.1c01352
None Unchecked Activity nan None 10.1016/j.ejmech.2020.113138
None Unchecked HC5 5.4 ug ml-1 10.1021/acs.jmedchem.2c01604
None Unchecked HC50 19.1 ug ml-1 10.1021/acs.jmedchem.2c01604
None Unchecked IC50 1490.0 nM 10.1021/acs.jmedchem.1c00614
None Unchecked IC50 2865.0 nM 10.1021/acs.jmedchem.8b01348
None Unchecked IC50 7840.0 nM 10.1016/j.ejmech.2019.111644
None Unchecked Inhibition 78.0 % 10.1016/j.ejmech.2019.111644
None Unchecked MBC>99.9 2.0 uM 10.1021/acs.jmedchem.9b00149
None Unchecked MBC>99.9 4.0 uM 10.1021/acs.jmedchem.8b01348
None Unchecked MBC99.9 2.0 uM 10.1021/acs.jmedchem.7b01729
None Unchecked MHC10 2.0 uM 10.1021/acs.jmedchem.1c01485
None Unchecked MHC10 4.0 uM 10.1021/acs.jmedchem.1c01485
None Unchecked MIC 16.0 ug.mL-1 10.1016/j.ejmech.2020.112233
None Unchecked MIC 4000.0 nM 10.1021/acs.jmedchem.0c00583
None Unchecked MIC100 32.0 uM 10.1016/j.ejmech.2020.112580
None Unchecked MIC>95 2.0 uM 10.1021/acs.jmedchem.8b01348
None Unchecked MIC95 2.0 uM 10.1021/acs.jmedchem.7b01729
None Unchecked MIC95 2.0 uM 10.1021/acs.jmedchem.9b00149
None Unchecked Potency 11220.2 nM None
None Unchecked Potency 19952.6 nM None
None Unchecked Ratio 0.5 None 10.1021/acs.jmedchem.1c01485
None Unchecked Ratio 0.92 None 10.1021/acs.jmedchem.8b01348
None Unchecked Ratio 0.96 None 10.1021/acs.jmedchem.8b01348
None Unchecked Ratio 1.0 None 10.1021/acs.jmedchem.9b00288
None Unchecked Ratio 1.14 None 10.1021/acs.jmedchem.8b01348
None Unchecked Ratio 1.31 None 10.1021/acs.jmedchem.8b01348
None Unchecked Ratio 3.1 None 10.1021/acs.jmedchem.2c01604
None Unchecked Ratio 6.1 None 10.1021/acs.jmedchem.2c01604
None Unchecked Stability nan % 10.1021/acs.jmedchem.0c00583
None Unchecked Stability nan % 10.1021/acs.jmedchem.8b01348

Metabolism Information