Sorazolon D2
AlkaPlorer ID: AK103288
Synonym: 'Sorazolon D2'
IUPAC Name: (1R,2S)-2-hydroxy-1-methoxy-1,2-dimethyl-9H-carbazole-3,4-dione
Structure
SMILES: CO[C@]1(C)C2=C(C(=O)C(=O)[C@@]1(C)O)C1=CC=CC=C1N2
InChI: InChI=1S/C15H15NO4/c1-14(19)13(18)11(17)10-8-6-4-5-7-9(8)16-12(10)15(14,2)20-3/h4-7,16,19H,1-3H3/t14-,15-/m1/s1
InChIKey: XDBOXJBUCNNICT-HUUCEWRRSA-N
Reference
Sorazolons, Carbazole Alkaloids from <i>Sorangium cellulosum</i> Strain Soce375
PubChem CID: 127047868
LOTUS: LTS0187150
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Sorangium cellulosum | Sorangium | Polyangiaceae | Polyangiales | None | Myxococcota | None | Bacteria |
Properties Information
Molecule Weight: 273.288
TPSA？: 79.39000000000001
MolLogP？: 1.5458999999999998
Number of H-Donors: 2
Number of H-Acceptors: 4
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bacillus subtilis | Bacillus subtilis | MIC | 8.3 | ug.mL-1 | 10.1021/acs.jnatprod.5b00997 |
| Candida albicans | Candida albicans | MIC | nan | None | 10.1021/acs.jnatprod.5b00997 |
| Escherichia coli | Escherichia coli | MIC | nan | None | 10.1021/acs.jnatprod.5b00997 |
| Micrococcus luteus | Micrococcus luteus | MIC | 16.6 | ug.mL-1 | 10.1021/acs.jnatprod.5b00997 |
| Mucor hiemalis | Mucor hiemalis | MIC | nan | None | 10.1021/acs.jnatprod.5b00997 |
| Mus musculus | L929 | IC50 | 76800.0 | nM | 10.1021/acs.jnatprod.5b00997 |
| Mycolicibacterium smegmatis | Mycolicibacterium smegmatis | MIC | nan | None | 10.1021/acs.jnatprod.5b00997 |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | MIC | nan | None | 10.1021/acs.jnatprod.5b00997 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 16.6 | ug.mL-1 | 10.1021/acs.jnatprod.5b00997 |
| Wickerhamomyces anomalus | Wickerhamomyces anomalus | MIC | nan | None | 10.1021/acs.jnatprod.5b00997 |