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Pyristriatin A

AlkaPlorer ID: AK104309

Synonym: 'Pyristriatin A', 'Pyristriatin B'

IUPAC Name: 2-hydroxy-1-[(1R,2R,5R,10R,11S,18S)-11-hydroxy-18-methoxy-2,5-dimethyl-8-propan-2-yl-19-oxa-15-azapentacyclo[11.6.1.02,10.05,9.017,20]icosa-8,13,15,17(20)-tetraen-16-yl]ethanone

Structure

SMILES: CO[C@H]1O[C@H]2C3=C(C=NC(C(=O)CO)=C31)C[C@H](O)[C@@H]1C3=C(C(C)C)CC[C@]3(C)CC[C@@]21C

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InChI: InChI=1S/C26H35NO5/c1-13(2)15-6-7-25(3)8-9-26(4)21(20(15)25)16(29)10-14-11-27-22(17(30)12-28)19-18(14)23(26)32-24(19)31-5/h11,13,16,21,23-24,28-29H,6-10,12H2,1-5H3/t16-,21+,23-,24-,25+,26+/m0/s1

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InChIKey: GOSSDHHYVCWSCT-IHMRMOLWSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Cyathus striatus Cyathus Nidulariaceae Agaricales Agaricomycetes Basidiomycota Fungi Eukaryota

Properties Information

Molecule Weight: 441.5680000000003

TPSA？: 88.88000000000001

MolLogP？: 4.058900000000004

Number of H-Donors: 2

Number of H-Acceptors: 6

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis Bacillus subtilis MIC 9.4 ug.mL-1 10.1021/acs.jnatprod.6b00194
Candida albicans Candida albicans MIC nan None 10.1021/acs.jnatprod.6b00194
Chromobacterium violaceum Chromobacterium violaceum MIC nan None 10.1021/acs.jnatprod.6b00194
Escherichia coli Escherichia coli MIC nan None 10.1021/acs.jnatprod.6b00194
Homo sapiens HUVEC IC50 5900.0 nM 10.1021/acs.jnatprod.6b00194
Homo sapiens KB 3-1 IC50 14700.0 nM 10.1021/acs.jnatprod.6b00194
Micrococcus luteus Micrococcus luteus MIC 16.7 ug.mL-1 10.1021/acs.jnatprod.6b00194
Mucor plumbeus Mucor plumbeus MIC 150.0 ug.mL-1 10.1021/acs.jnatprod.6b00194
Mus musculus L929 IC50 16300.0 nM 10.1021/acs.jnatprod.6b00194
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC nan None 10.1021/acs.jnatprod.6b00194
Rhodotorula glutinis Rhodotorula glutinis MIC 16.7 ug.mL-1 10.1021/acs.jnatprod.6b00194
Schizosaccharomyces pombe Schizosaccharomyces pombe MIC 16.7 ug.mL-1 10.1021/acs.jnatprod.6b00194
Staphylococcus aureus Staphylococcus aureus MIC 16.7 ug.mL-1 10.1021/acs.jnatprod.6b00194
Wickerhamomyces anomalus Wickerhamomyces anomalus MIC nan None 10.1021/acs.jnatprod.6b00194

Metabolism Information