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Alvocidib

AlkaPlorer ID: AK105679

Synonym: None

IUPAC Name: 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one

Structure

SMILES: CN1CC[C@H](C2=C(O)C=C(O)C3=C2OC(C2=CC=CC=C2Cl)=CC3=O)[C@H](O)C1

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InChI: InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1

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InChIKey: BIIVYFLTOXDAOV-YVEFUNNKSA-N

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Reference

PubChem CID: 5287969

CAS: 131740-09-5

NPASS: NPC264938

Source

Species Genus Family Order Class Phylum Kingdom Domain
Dysoxylum binectariferum Dysoxylum Meliaceae Sapindales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 401.8460000000001

TPSA？: 94.14

MolLogP？: 3.3046000000000024

Number of H-Donors: 3

Number of H-Acceptors: 6

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Gallus gallus Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Inhibition nan % 10.1016/j.bmcl.2013.11.081
Homo sapiens 26S protease regulatory subunit 6B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens A2780 Activity 0.6 % 10.1021/jm301475f
Homo sapiens A2780 Activity 3.3 % 10.1021/jm301475f
Homo sapiens A2780 Activity 3.4 % 10.1021/jm301475f
Homo sapiens A2780 Activity 5.7 % 10.1021/jm301475f
Homo sapiens A2780 Activity 37.9 % 10.1021/jm301475f
Homo sapiens A2780 Activity 38.8 % 10.1021/jm301475f
Homo sapiens A2780 Activity 51.6 % 10.1021/jm301475f
Homo sapiens A2780 Activity 54.0 % 10.1021/jm301475f
Homo sapiens A2780 Activity 88.1 % 10.1021/jm301475f
Homo sapiens A2780 Activity nan None 10.1021/jm301475f
Homo sapiens A2780 Activity nan None 10.1038/nchembio.90
Homo sapiens A2780 GI50 23.0 nM 10.1021/jm301475f
Homo sapiens A2780 GI50 29.0 nM 10.1021/jm301475f
Homo sapiens A2780 GI50 31.0 nM 10.1021/jm301475f
Homo sapiens A2780 GI50 64.0 nM 10.1016/j.ejmech.2021.113244
Homo sapiens A2780 IC50 38.0 nM 10.1021/jm0201520
Homo sapiens A2780 IC50 56.0 nM 10.1021/jm0201520
Homo sapiens A2780 IC50 65.0 nM 10.1021/jm0201520
Homo sapiens A2780 IC50 71.0 nM 10.1016/j.bmcl.2004.02.105
Homo sapiens A2780 IC50 71.0 nM 10.1021/jm0305568
Homo sapiens A2780 IC50 78.0 nM 10.1021/jm0201520
Homo sapiens A2780 IC50 15000.0 nM 10.1021/jm000231g
Homo sapiens A2780 Inhibition nan % 10.1038/nchembio.90
Homo sapiens A2780 LCK 0.6 None 10.1021/jm0201520
Homo sapiens A2780 MTD 7.5 mg kg-1 10.1021/jm0305568
Homo sapiens A-431 IC50 75.0 nM 10.1021/jm0201520
Homo sapiens A549 CC50 100000.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens A549 GI50 140.0 nM 10.1039/c4md00412d
Homo sapiens A549 GI50 145.0 nM 10.1016/j.ejmech.2021.113244
Homo sapiens A549 IC50 96.0 nM 10.1021/jm0201520
Homo sapiens ABAE IC50 45.0 nM 10.1021/jm0201520
Homo sapiens ACHN Activity 68.0 % 10.1016/j.bmc.2009.12.077
Homo sapiens ACHN Activity 71.0 % 10.1016/j.bmcl.2012.04.008
Homo sapiens ACHN Activity 71.0 % 10.1021/acsmedchemlett.7b00545
Homo sapiens ACHN GI 68.0 % 10.1016/j.bmc.2009.11.066
Homo sapiens ACHN GI 73.0 % 10.1007/s00044-011-9834-7
Homo sapiens Actin-related protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Actin-related protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1 IC50 nan None 10.1021/acs.jmedchem.1c00271
Homo sapiens Activin receptor type-1 Kd 1900.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-1 Kd 1900.0 nM 10.1038/nbt.1990
Homo sapiens Activin receptor type-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-1B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Activin receptor type-1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-2A Kd 3100.0 nM 10.1038/nbt.1990
Homo sapiens Activin receptor type-2A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-2B Kd 2400.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-2B Kd 2400.0 nM 10.1038/nbt.1990
Homo sapiens Activin receptor type-2B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acyl-CoA dehydrogenase family member 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acyl-CoA dehydrogenase family member 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adaptor-associated kinase Kd 5300.0 nM 10.1038/nbt1358
Homo sapiens Adaptor-associated kinase Kd 5300.0 nM 10.1038/nbt.1990
Homo sapiens Adaptor-associated kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adaptor-associated kinase Kd nan None 10.1038/nbt1068
Homo sapiens Adenine phosphoribosyltransferase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adenosine kinase Kd 2441.0 nM 10.1126/science.aan4368
Homo sapiens Adenylate kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ADP/ATP translocase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ADP/ATP translocase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ALK tyrosine kinase receptor Kd 670.0 nM 10.1038/nbt1358
Homo sapiens ALK tyrosine kinase receptor Kd 670.0 nM 10.1038/nbt.1990
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 6600.0 nM 10.1038/nbt1068
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens AMP-activated protein kinase, gamma-1 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, gamma-2 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ankyrin repeat and protein kinase domain-containing protein 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ankyrin repeat and protein kinase domain-containing protein 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens ATP-binding cassette sub-family G member 2 Activity nan None 10.1124/mol.64.6.1452
Homo sapiens ATP-binding cassette sub-family G member 2 Activity nan None None
Homo sapiens ATP-dependent RNA helicase DDX1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DDX3X Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DDX42 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DHX30 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens BJ EC50 86206.9 nM 10.1016/j.ejmech.2018.01.004
Homo sapiens BMP-2-inducible protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BMP-2-inducible protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens BMP-2-inducible protein kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens BMP-2-inducible protein kinase Kd nan None 10.1038/nbt1068
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-1B Kd 450.0 nM 10.1038/nbt.1990
Homo sapiens Bone morphogenetic protein receptor type-1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Brain glycogen phosphorylase Kd 3569.0 nM 10.1126/science.aan4368
Homo sapiens Breakpoint cluster region protein Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bromodomain testis-specific protein IC50 18000.0 nM 10.1021/acs.jmedchem.6b00438
Homo sapiens BR serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BR serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens BR serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BR serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Caco-2 IC50 86.0 nM 10.1021/jm0201520
Homo sapiens Calu-1 Activity 68.0 % 10.1016/j.bmc.2009.12.077
Homo sapiens Calu-1 Activity 74.0 % 10.1021/acsmedchemlett.7b00545
Homo sapiens Calu-1 Activity 88.0 % 10.1016/j.bmcl.2012.04.008
Homo sapiens Calu-1 GI 68.0 % 10.1016/j.bmc.2009.11.066
Homo sapiens Calu-1 GI 82.0 % 10.1007/s00044-011-9834-7
Homo sapiens CaM kinase I alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase I alpha Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase I delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I delta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase I delta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase I gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase I gamma Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II alpha Kd 1300.0 nM 10.1038/nbt1068
Homo sapiens CaM kinase II alpha Kd 1700.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II alpha Kd 1700.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase II beta Kd 2600.0 nM 10.1038/nbt1068
Homo sapiens CaM kinase II beta Kd 4700.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase II beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II delta Kd 1600.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase II delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase II delta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II gamma Kd 2600.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase II gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase II gamma Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase IV Kd 3200.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase IV Kd 3200.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase IV Kd 5460.0 nM 10.1126/science.aan4368
Homo sapiens CaM-kinase kinase alpha Kd 19.0 nM 10.1038/nbt1068
Homo sapiens CaM-kinase kinase alpha Kd 79.0 nM 10.1038/nbt1358
Homo sapiens CaM-kinase kinase alpha Kd 79.0 nM 10.1038/nbt.1990
Homo sapiens CaM-kinase kinase beta Kd 320.0 nM 10.1038/nbt1068
Homo sapiens CaM-kinase kinase beta Kd 430.0 nM 10.1038/nbt1358
Homo sapiens CaM-kinase kinase beta Kd 430.0 nM 10.1038/nbt.1990
Homo sapiens CaM-kinase kinase beta Kd 1379.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase, gamma catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase (PKA) IC50 50000.0 nM 10.1021/jm0201520
Homo sapiens cAMP-dependent protein kinase (PKA) IC50 960000.0 nM 10.1016/s0960-894x(00)00156-6
Homo sapiens cAMP-dependent protein kinase type II-alpha regulatory subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I alpha Kd 3100.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I delta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I epsilon Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I epsilon Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I epsilon Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I epsilon Kd nan None 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 1 Kd 1200.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I gamma 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I gamma 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 1 Kd nan None 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I gamma 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I gamma 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 2 Kd nan None 10.1038/nbt1068
Homo sapiens Casein kinase II alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase II alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase II alpha (prime) Kd 6582.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase II alpha (prime) Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase II alpha (prime) Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I isoform alpha-like Kd 2400.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I isoform alpha-like Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I isoform gamma-3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I isoform gamma-3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I isoform gamma-3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CCRF-CEM IC50 52.0 nM 10.1021/jm0201520
Homo sapiens CDK12/Cyclin K IC50 1370.0 nM 10.1016/j.ejmech.2022.114603
Homo sapiens CDK2/Cyclin A2 Activity 11.0 % 10.1016/j.ejmech.2020.112355
Homo sapiens CDK2/Cyclin A2 Activity 26.0 % 10.1016/j.ejmech.2020.112355
Homo sapiens CDK2/Cyclin A2 IC50 100.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens CDK2/Cyclin A2 IC50 100.0 nM 10.1021/acs.jmedchem.1c02064
Homo sapiens CDK2/Cyclin A2 IC50 106.0 nM 10.1021/acs.jmedchem.7b00663
Homo sapiens CDK2/Cyclin A2 IC50 161.4 nM 10.1021/acs.jmedchem.6b00150
Homo sapiens CDK2/Cyclin A2 IC50 379.0 nM 10.1016/j.ejmech.2020.112355
Homo sapiens CDK2/Cyclin A2 IC50 405.0 nM 10.1021/acs.jmedchem.6b00150
Homo sapiens CDK6/cyclin D3 IC50 395.0 nM 10.1021/acs.jmedchem.6b00150
Homo sapiens CDK7/Cyclin H/MNAT1 IC50 514.0 nM 10.1021/acs.jmedchem.6b00150
Homo sapiens CDK9/cyclin T1 Activity 1.0 % 10.1016/j.ejmech.2020.112355
Homo sapiens CDK9/cyclin T1 Activity 5.0 % 10.1016/j.ejmech.2020.112355
Homo sapiens CDK9/cyclin T1 Delta Tm 5.03 degrees C 10.1021/jm301495v
Homo sapiens CDK9/cyclin T1 IC50 2.5 nM 10.1021/acs.jmedchem.6b00150
Homo sapiens CDK9/cyclin T1 IC50 3.7 nM 10.1021/acs.jmedchem.7b00663
Homo sapiens CDK9/cyclin T1 IC50 4.59 nM 10.1039/c4md00412d
Homo sapiens CDK9/cyclin T1 IC50 6.0 nM 10.1021/jm401742r
Homo sapiens CDK9/cyclin T1 IC50 11.0 nM 10.1016/j.ejmech.2020.112355
Homo sapiens CDK9/cyclin T1 IC50 11.0 nM 10.1021/acs.jmedchem.6b00150
Homo sapiens CDK9/cyclin T1 IC50 20.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens CDK9/cyclin T1 IC50 20.0 nM 10.1021/acs.jmedchem.1c02064
Homo sapiens CDK9/cyclin T1 IC50 20.0 nM 10.1021/acs.jmedchem.7b01765
Homo sapiens CDK9/cyclin T1 IC50 144.0 nM 10.1016/j.ejmech.2022.114603
Homo sapiens CDK9/cyclin T1 Inhibition 100.0 % 10.1021/jm401742r
Homo sapiens CDK9/cyclin T1 Ki 3.0 nM 10.1021/jm301495v
Homo sapiens Cell division cycle 2-like protein kinase 6 Kd 57.0 nM 10.1038/nbt1358
Homo sapiens Cell division cycle 2-like protein kinase 6 Kd 57.0 nM 10.1038/nbt.1990
Homo sapiens Cell division cycle 7-related protein kinase Inhibition nan % 10.1038/nchembio.90
Homo sapiens Cell division protein kinase 8 Kd 120.0 nM 10.1038/nbt1358
Homo sapiens Cell division protein kinase 8 Kd 120.0 nM 10.1038/nbt.1990
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cGMP-dependent protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cGMP-dependent protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Choline-phosphate cytidylyltransferase A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Chromodomain-helicase-DNA-binding protein 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Citron Rho-interacting kinase Kd 110.0 nM 10.1038/nbt1358
Homo sapiens Citron Rho-interacting kinase Kd 110.0 nM 10.1038/nbt.1990
Homo sapiens Citron Rho-interacting kinase Kd 738.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 1 Kd 1600.0 nM 10.1038/nbt.1990
Homo sapiens c-Jun N-terminal kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 1 Kd nan None 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens c-Jun N-terminal kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 3 Kd 5500.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 3 Kd 5500.0 nM 10.1038/nbt.1990
Homo sapiens c-Jun N-terminal kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 3 Kd nan None 10.1038/nbt1068
Homo sapiens Cyclin-dependent kinase Inhibition nan % 10.1038/nchembio.90
Homo sapiens Cyclin-dependent kinase 1 IC50 10.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Cyclin-dependent kinase 1 IC50 20.0 nM 10.1016/j.ejmech.2020.112571
Homo sapiens Cyclin-dependent kinase 1 IC50 30.0 nM 10.1016/j.ejmech.2017.08.071
Homo sapiens Cyclin-dependent kinase 1 IC50 30.0 nM 10.1016/j.ejmech.2019.03.064
Homo sapiens Cyclin-dependent kinase 1 IC50 30.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 1 IC50 30.0 nM 10.1016/j.ejmech.2022.114875
Homo sapiens Cyclin-dependent kinase 1 IC50 30.0 nM 10.1021/acs.jmedchem.0c00744
Homo sapiens Cyclin-dependent kinase 1 IC50 30.0 nM 10.1021/acs.jmedchem.0c01180
Homo sapiens Cyclin-dependent kinase 1 IC50 30.0 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens Cyclin-dependent kinase 1 IC50 30.0 nM 10.1021/acs.jmedchem.6b00438
Homo sapiens Cyclin-dependent kinase 1 IC50 30.0 nM 10.1021/acs.jnatprod.5b00947
Homo sapiens Cyclin-dependent kinase 1 IC50 30.0 nM 10.1038/nchembio.90
Homo sapiens Cyclin-dependent kinase 1 IC50 30.0 nM 10.1039/d2md00040g
Homo sapiens Cyclin-dependent kinase 1 IC50 30.0 nM 10.1208/aapsj080125
Homo sapiens Cyclin-dependent kinase 1 Kd 1516.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 1 Ki 40.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens Cyclin-dependent kinase 1 Ki 70.0 nM 10.1021/jm301495v
Homo sapiens Cyclin-dependent kinase 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 12 Kd 157.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 13 Kd 430.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 13 Kd 1814.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 30.0 nM 10.1016/j.bmcl.2004.02.105
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 30.0 nM 10.1016/s0960-894x(03)00034-9
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 30.0 nM 10.1021/jm0201520
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 200.0 nM 10.1016/j.bmcl.2005.01.052
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 200.0 nM 10.1021/jm021090g
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 210.0 nM 10.1021/jm049353p
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 400.0 nM 10.1016/j.tips.2004.07.006
Homo sapiens Cyclin-dependent kinase 1/cyclin B ID50 0.4 uM 10.1021/jm991182e
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 27.0 nM 10.1021/acs.jmedchem.6b00150
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 30.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 30.0 nM 10.1016/j.ejmech.2010.06.034
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 30.0 nM 10.1016/j.ejmech.2021.113281
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 30.0 nM 10.1016/j.ejmech.2022.114603
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 30.0 nM 10.1021/jm000231g
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 30.0 nM 10.1021/jm401073p
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 200.0 nM 10.1016/s0960-894x(00)00156-6
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 330.0 nM 10.1016/j.bmc.2008.06.055
Homo sapiens Cyclin-dependent kinase 2 Cell cycle 1.0 nM 10.1021/jm0201520
Homo sapiens Cyclin-dependent kinase 2 Cell cycle 2.0 nM 10.1021/jm0201520
Homo sapiens Cyclin-dependent kinase 2 Cell cycle 9.0 nM 10.1021/jm0201520
Homo sapiens Cyclin-dependent kinase 2 Cell cycle 12.0 nM 10.1021/jm0201520
Homo sapiens Cyclin-dependent kinase 2 Cell cycle 16.0 nM 10.1021/jm0201520
Homo sapiens Cyclin-dependent kinase 2 Cell cycle 23.0 nM 10.1021/jm0201520
Homo sapiens Cyclin-dependent kinase 2 Cell cycle 25.0 nM 10.1021/jm0201520
Homo sapiens Cyclin-dependent kinase 2 Cell cycle 60.0 nM 10.1021/jm0201520
Homo sapiens Cyclin-dependent kinase 2 Cell cycle 61.0 nM 10.1021/jm0201520
Homo sapiens Cyclin-dependent kinase 2 IC50 10.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Cyclin-dependent kinase 2 IC50 20.0 nM 10.1016/j.ejmech.2020.112571
Homo sapiens Cyclin-dependent kinase 2 IC50 40.0 nM 10.1038/nchembio.90
Homo sapiens Cyclin-dependent kinase 2 IC50 70.0 nM 10.1021/acs.jmedchem.0c00744
Homo sapiens Cyclin-dependent kinase 2 IC50 70.0 nM 10.1039/d2md00040g
Homo sapiens Cyclin-dependent kinase 2 IC50 170.0 nM 10.1016/j.ejmech.2017.08.071
Homo sapiens Cyclin-dependent kinase 2 IC50 170.0 nM 10.1016/j.ejmech.2019.03.064
Homo sapiens Cyclin-dependent kinase 2 IC50 170.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 2 IC50 170.0 nM 10.1016/j.ejmech.2022.114875
Homo sapiens Cyclin-dependent kinase 2 IC50 170.0 nM 10.1021/acs.jmedchem.0c01180
Homo sapiens Cyclin-dependent kinase 2 IC50 170.0 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens Cyclin-dependent kinase 2 IC50 170.0 nM 10.1021/acs.jmedchem.6b00438
Homo sapiens Cyclin-dependent kinase 2 IC50 170.0 nM 10.1021/acs.jnatprod.5b00947
Homo sapiens Cyclin-dependent kinase 2 IC50 170.0 nM 10.1208/aapsj080125
Homo sapiens Cyclin-dependent kinase 2 IC50 400.0 nM 10.1021/acs.jmedchem.0c01198
Homo sapiens Cyclin-dependent kinase 2 Kd 200.0 nM 10.1038/nbt1068
Homo sapiens Cyclin-dependent kinase 2 Kd 550.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 2 Kd 550.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 2 Kd 1337.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 2 Ki 40.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens Cyclin-dependent kinase 2 Ki 190.0 nM 10.1021/jm301495v
Homo sapiens Cyclin-dependent kinase 2 Selectivity 0.1696 None 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 70.0 nM 10.1021/jm000231g
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 1500.0 nM 10.1016/j.bmc.2006.10.063
Homo sapiens Cyclin-dependent kinase 2/cyclin A ID50 0.1 uM 10.1021/jm991182e
Homo sapiens Cyclin-dependent kinase 2/cyclin A Ki 190.0 nM 10.1021/jm301495v
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 170.0 nM 10.1016/j.bmcl.2004.02.105
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 170.0 nM 10.1016/s0960-894x(03)00034-9
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 170.0 nM 10.1021/jm000231g
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 330.0 nM 10.1021/jm0201520
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 960.0 nM 10.1016/j.bmcl.2005.01.052
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 330000.0 nM 10.1021/jm0305568
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 100.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 130.0 nM 10.1039/c4md00412d
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 170.0 nM 10.1016/j.ejmech.2021.113281
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 170.0 nM 10.1021/jm401073p
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 282.0 nM 10.1021/acs.jmedchem.6b00150
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 Inhibition 99.0 % 10.1021/jm401742r
Homo sapiens Cyclin-dependent kinase 3 Kd 410.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 3 Kd 410.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 4 IC50 10.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Cyclin-dependent kinase 4 IC50 20.0 nM 10.1016/j.ejmech.2020.112571
Homo sapiens Cyclin-dependent kinase 4 IC50 100.0 nM 10.1016/j.ejmech.2017.08.071
Homo sapiens Cyclin-dependent kinase 4 IC50 100.0 nM 10.1016/j.ejmech.2019.03.064
Homo sapiens Cyclin-dependent kinase 4 IC50 100.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 4 IC50 100.0 nM 10.1016/j.ejmech.2022.114875
Homo sapiens Cyclin-dependent kinase 4 IC50 100.0 nM 10.1021/acs.jmedchem.0c00744
Homo sapiens Cyclin-dependent kinase 4 IC50 100.0 nM 10.1021/acs.jmedchem.0c01180
Homo sapiens Cyclin-dependent kinase 4 IC50 100.0 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens Cyclin-dependent kinase 4 IC50 100.0 nM 10.1021/acs.jmedchem.6b00438
Homo sapiens Cyclin-dependent kinase 4 IC50 100.0 nM 10.1021/acs.jnatprod.5b00947
Homo sapiens Cyclin-dependent kinase 4 IC50 100.0 nM 10.1039/d0md00012d
Homo sapiens Cyclin-dependent kinase 4 IC50 100.0 nM 10.1039/d2md00040g
Homo sapiens Cyclin-dependent kinase 4 IC50 100.0 nM 10.1208/aapsj080125
Homo sapiens Cyclin-dependent kinase 4 Inhibition nan % 10.1007/s00044-011-9867-y
Homo sapiens Cyclin-dependent kinase 4 Kd 3.3 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 4 Kd 9.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 4 Ki 40.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens Cyclin-dependent kinase 4/cyclin D IC50 100.0 nM 10.1016/j.bmcl.2004.02.105
Homo sapiens Cyclin-dependent kinase 4/cyclin D IC50 100.0 nM 10.1016/s0960-894x(03)00034-9
Homo sapiens Cyclin-dependent kinase 4/cyclin D ID50 0.4 uM 10.1021/jm991182e
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 20.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 20.0 nM 10.1021/acs.jmedchem.1c02064
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 100.0 nM 10.1016/j.ejmech.2022.114603
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 100.0 nM 10.1021/jm000231g
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 132.0 nM 10.1021/acs.jmedchem.6b00150
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 150.0 nM 10.1021/jm0201520
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 180.0 nM 10.1016/j.bmcl.2005.01.052
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 200.0 nM 10.1016/s0960-894x(00)00156-6
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 400.0 nM 10.1016/j.ejmech.2021.113281
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 400.0 nM 10.1021/jm401073p
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 Inhibition 84.0 % 10.1021/jm401742r
Homo sapiens Cyclin-dependent kinase 5 IC50 170.0 nM 10.1016/j.ejmech.2019.03.064
Homo sapiens Cyclin-dependent kinase 5 IC50 170.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 5 IC50 170.0 nM 10.1021/acs.jmedchem.0c00744
Homo sapiens Cyclin-dependent kinase 5 IC50 170.0 nM 10.1039/d2md00040g
Homo sapiens Cyclin-dependent kinase 5 Kd 43.0 nM 10.1038/nbt1068
Homo sapiens Cyclin-dependent kinase 5 Kd 107.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 5 Kd 110.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 5 Kd 110.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Activity 13.0 % 10.1016/j.ejmech.2020.112355
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Activity 36.0 % 10.1016/j.ejmech.2020.112355
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 60.0 nM 10.1021/jm201727w
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 170.0 nM 10.1021/jm021090g
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 170.0 nM 10.1021/jm049353p
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 272.0 nM 10.1016/j.ejmech.2020.112355
Homo sapiens Cyclin-dependent kinase 6 IC50 20.0 nM 10.1016/j.ejmech.2020.112571
Homo sapiens Cyclin-dependent kinase 6 IC50 60.0 nM 10.1021/acs.jmedchem.0c00744
Homo sapiens Cyclin-dependent kinase 6 IC50 60.0 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens Cyclin-dependent kinase 6 IC50 60.0 nM 10.1039/d2md00040g
Homo sapiens Cyclin-dependent kinase 6 IC50 80.0 nM 10.1007/s00044-009-9233-5
Homo sapiens Cyclin-dependent kinase 6 IC50 80.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 6 IC50 80.0 nM 10.1021/jm049353p
Homo sapiens Cyclin-dependent kinase 6 Inhibition nan % 10.1007/s00044-011-9867-y
Homo sapiens Cyclin-dependent kinase 6 Kd 3259.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 7 Activity nan None 10.1016/j.bmcl.2021.128061
Homo sapiens Cyclin-dependent kinase 7 IC50 10.0 nM 10.1021/acs.jmedchem.0c00744
Homo sapiens Cyclin-dependent kinase 7 IC50 10.0 nM 10.1039/d2md00040g
Homo sapiens Cyclin-dependent kinase 7 IC50 110.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 7 IC50 875.0 nM 10.1038/nchembio.90
Homo sapiens Cyclin-dependent kinase 7 Inhibition nan % 10.1038/nchembio.90
Homo sapiens Cyclin-dependent kinase 7 Kd 23.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 7 Kd 23.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 7 Kd 675.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 110.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 400.0 nM 10.1016/s0960-894x(03)00034-9
Homo sapiens Cyclin-dependent kinase 9 IC50 3.0 nM 10.1021/acs.jmedchem.0c00744
Homo sapiens Cyclin-dependent kinase 9 IC50 3.0 nM 10.1039/d2md00040g
Homo sapiens Cyclin-dependent kinase 9 IC50 10.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Cyclin-dependent kinase 9 IC50 20.0 nM 10.1016/j.ejmech.2017.08.071
Homo sapiens Cyclin-dependent kinase 9 IC50 20.0 nM 10.1016/j.ejmech.2019.03.064
Homo sapiens Cyclin-dependent kinase 9 IC50 20.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 9 IC50 20.0 nM 10.1016/j.ejmech.2020.112355
Homo sapiens Cyclin-dependent kinase 9 IC50 20.0 nM 10.1016/j.ejmech.2020.112571
Homo sapiens Cyclin-dependent kinase 9 IC50 20.0 nM 10.1016/j.ejmech.2022.114875
Homo sapiens Cyclin-dependent kinase 9 IC50 20.0 nM 10.1038/nchembio.90
Homo sapiens Cyclin-dependent kinase 9 Inhibition nan % 10.1016/j.bmcl.2021.128061
Homo sapiens Cyclin-dependent kinase 9 Inhibition nan % 10.1016/j.ejmech.2020.112424
Homo sapiens Cyclin-dependent kinase 9 Inhibition nan % 10.1021/jm301475f
Homo sapiens Cyclin-dependent kinase 9 Inhibition nan % 10.1038/nchembio.90
Homo sapiens Cyclin-dependent kinase 9 Kd 6.4 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 9 Kd 6.4 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 9 Kd 7.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 9 Ki 3.0 nM 10.1021/jm301495v
Homo sapiens Cyclin-dependent kinase-like 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase-like 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase-like 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase-like 5 Kd 7.1 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase-like 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cysteine--tRNA ligase, cytoplasmic Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cytochrome c1, heme protein, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens dCTP pyrophosphatase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Death-associated protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Death-associated protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Death-associated protein kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Death-associated protein kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Death-associated protein kinase 3 Kd nan None 10.1038/nbt1068
Homo sapiens Delta(24)-sterol reductase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Deoxycytidine kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Discoidin domain-containing receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Discoidin domain-containing receptor 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Discoidin domain-containing receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DnaJ homolog subfamily A member 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA replication licensing factor MCM4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA topoisomerase II alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA topoisomerase II beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual serine/threonine and tyrosine protein kinase Kd 4200.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 1200.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Kd 2300.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 5 Kd 180.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase CLK2 Kd 1400.0 nM 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK2 Kd 2200.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK2 Kd 2200.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase CLK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity protein kinase CLK3 Kd 1000.0 nM 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK3 Kd 1600.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK3 Kd 1600.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase CLK4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase CLK4 Kd nan None 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase TTK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase TTK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase TTK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity protein kinase TTK Kd nan None 10.1038/nbt1068
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity testis-specific protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kd 77.0 nM 10.1038/nbt.1990
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kd 910.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kd 84.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kd 84.0 nM 10.1038/nbt.1990
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificty protein kinase CLK1 Kd 1700.0 nM 10.1038/nbt1358
Homo sapiens Dual specificty protein kinase CLK1 Kd 1700.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificty protein kinase CLK1 Kd 2200.0 nM 10.1038/nbt1068
Homo sapiens Dual specificty protein kinase CLK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dynamin-like 120 kDa protein, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Electron transfer flavoprotein subunit beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Elongation factor Tu, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 1 Kd 2300.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 2 Kd 2500.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 2 Kd 2500.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 3 Kd 3300.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 3 Kd 3300.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 4 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 5 Kd 3500.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 5 Kd 4000.0 nM 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 6 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 7 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 8 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 8 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 8 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 1 Kd 1500.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 1 Kd 2200.0 nM 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 4 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Epidermal growth factor receptor erbB1 IC50 7600.0 nM 10.1021/jm0201520
Homo sapiens Epidermal growth factor receptor erbB1 IC50 21000.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens Epidermal growth factor receptor erbB1 IC50 22000.0 nM 10.1021/jm000231g
Homo sapiens Epidermal growth factor receptor erbB1 Kd 520.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 750.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1200.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1400.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1400.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1600.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1700.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 2200.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 2300.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 2300.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 3000.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 3700.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 4000.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Epidermal growth factor receptor erbB1 Kd nan None 10.1038/nbt1068
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 1 Kd 58.0 nM 10.1126/science.aan4368
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 1 Kd 870.0 nM 10.1038/nbt.1990
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Eukaryotic translation initiation factor 5B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Exosome RNA helicase MTR4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ferrochelatase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Fibroblast growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Fibroblast growth factor receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Fibroblast growth factor receptor 1 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Fibroblast growth factor receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Fibroblast growth factor receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Focal adhesion kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Focal adhesion kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Focal adhesion kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Focal adhesion kinase 1 Kd nan None 10.1038/nbt1068
Homo sapiens G1/S-specific cyclin D1 Inhibition nan % 10.1007/s00044-011-9867-y
Homo sapiens General transcription and DNA repair factor IIH helicase subunit XPD Kd 921.0 nM 10.1126/science.aan4368
Homo sapiens Glycine--tRNA ligase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 IC50 280.0 nM 10.1021/jm049353p
Homo sapiens Glycogen synthase kinase-3 alpha IC50 770.0 nM 10.1021/acs.jmedchem.1c00271
Homo sapiens Glycogen synthase kinase-3 alpha Kd 971.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 alpha Kd 1300.0 nM 10.1038/nbt1358
Homo sapiens Glycogen synthase kinase-3 alpha Kd 1300.0 nM 10.1038/nbt.1990
Homo sapiens Glycogen synthase kinase-3 beta Activity 10.0 % 10.1016/j.ejmech.2020.112355
Homo sapiens Glycogen synthase kinase-3 beta Activity 50.0 % 10.1016/j.ejmech.2020.112355
Homo sapiens Glycogen synthase kinase-3 beta IC50 491.0 nM 10.1021/acs.jmedchem.1c00271
Homo sapiens Glycogen synthase kinase-3 beta IC50 1184.0 nM 10.1016/j.ejmech.2020.112355
Homo sapiens Glycogen synthase kinase-3 beta Kd 730.0 nM 10.1038/nbt1358
Homo sapiens Glycogen synthase kinase-3 beta Kd 730.0 nM 10.1038/nbt.1990
Homo sapiens Glycogen synthase kinase-3 beta Kd 740.0 nM 10.1126/science.aan4368
Homo sapiens G-protein coupled receptor kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens G protein-coupled receptor kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens G protein-coupled receptor kinase 7 Kd 980.0 nM 10.1038/nbt.1990
Homo sapiens GTP-binding nuclear protein Ran Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Guanine nucleotide-binding protein G(i) subunit alpha-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens HCT-116 Activity 71.0 % 10.1016/j.bmc.2009.12.077
Homo sapiens HCT-116 Activity 71.0 % 10.1021/acsmedchemlett.7b00545
Homo sapiens HCT-116 Activity 78.0 % 10.1016/j.bmcl.2012.04.008
Homo sapiens HCT-116 Activity 87.0 % 10.1016/j.bmc.2010.06.046
Homo sapiens HCT-116 EC50 59.0 nM 10.1021/acsmedchemlett.6b00044
Homo sapiens HCT-116 GI 71.0 % 10.1016/j.bmc.2009.11.066
Homo sapiens HCT-116 GI 83.0 % 10.1007/s00044-011-9834-7
Homo sapiens HCT-116 GI50 56.0 nM 10.1016/j.ejmech.2021.113244
Homo sapiens HCT-116 IC50 17.0 nM 10.1021/jm0201520
Homo sapiens HCT-116 IC50 18.0 nM 10.1021/jm0201520
Homo sapiens HCT-116 IC50 20.0 nM 10.1016/j.ejmech.2020.112355
Homo sapiens HCT-116 IC50 21.0 nM 10.1021/jm0201520
Homo sapiens HCT-116 IC50 13000.0 nM 10.1021/jm000231g
Homo sapiens HeLa GI50 43.0 nM 10.1016/j.ejmech.2021.113244
Homo sapiens Heme oxygenase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Hepatocyte growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Hepatocyte growth factor receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Hepatocyte growth factor receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens HepG2 EC50 146.4 nM 10.1016/j.ejmech.2018.01.004
Homo sapiens Histone deacetylase 6 Inhibition -16.88 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -11.25 % 10.6019/CHEMBL4808148
Homo sapiens HL-60 Activity 72.0 % 10.1016/j.bmc.2010.06.046
Homo sapiens HL-60 IC50 46.0 nM 10.1021/jm0201520
Homo sapiens Homeodomain-interacting protein kinase 1 Kd 6800.0 nM 10.1038/nbt.1990
Homo sapiens Homeodomain-interacting protein kinase 2 Kd 4200.0 nM 10.1038/nbt.1990
Homo sapiens Homeodomain-interacting protein kinase 3 Kd 4300.0 nM 10.1038/nbt.1990
Homo sapiens Homeodomain-interacting protein kinase 4 Kd 2000.0 nM 10.1038/nbt.1990
Homo sapiens Homo sapiens Activity 0.07 nM min-1 (mg of protein)-1 10.1021/jm0201520
Homo sapiens Homo sapiens Activity 67.0 % 10.1021/acs.jmedchem.6b00150
Homo sapiens Homo sapiens Activity 91.0 % 10.1021/jm0201520
Homo sapiens Hormonally up-regulated neu tumor-associated kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens HS27 IC50 51.0 nM 10.1021/jm0201520
Homo sapiens HT-29 GI50 131.0 nM 10.1016/j.ejmech.2021.113244
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 3100.0 nM 10.1038/nbt1358
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 3100.0 nM 10.1038/nbt.1990
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Inosine-5'-monophosphate dehydrogenase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin-like growth factor I receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin-like growth factor I receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Insulin-like growth factor I receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Insulin receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin receptor Kd nan None 10.1038/nbt1068
Homo sapiens Insulin receptor-related protein Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin receptor-related protein Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Kd 5200.0 nM 10.1038/nbt1358
Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Kd 5200.0 nM 10.1038/nbt.1990
Homo sapiens Interleukin-1 receptor-associated kinase 1 Kd 540.0 nM 10.1038/nbt.1990
Homo sapiens Interleukin-1 receptor-associated kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 4 Kd 1500.0 nM 10.1038/nbt.1990
Homo sapiens Interleukin-1 receptor-associated kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Isoleucine--tRNA ligase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens K562 IC50 125.0 nM 10.1016/j.ejmech.2020.112355
Homo sapiens K562 IC50 130.0 nM 10.1021/jm0201520
Homo sapiens KB GI50 160.0 nM 10.1039/c4md00412d
Homo sapiens KOPN-8 Activity nan None 10.1016/j.ejmech.2018.01.004
Homo sapiens KOPN-8 EC50 192.6 nM 10.1016/j.ejmech.2018.01.004
Homo sapiens KOPN-8 FC 0.0 None 10.1016/j.ejmech.2018.01.004
Homo sapiens KOPN-8 FC 0.2 None 10.1016/j.ejmech.2018.01.004
Homo sapiens La-related protein 7 Ki 3.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Kd 1000.0 nM 10.1038/nbt.1990
Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Kd 2000.0 nM 10.1038/nbt.1990
Homo sapiens Leukocyte tyrosine kinase receptor Kd 2200.0 nM 10.1038/nbt1358
Homo sapiens Leukocyte tyrosine kinase receptor Kd 2200.0 nM 10.1038/nbt.1990
Homo sapiens LIM domain kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens LIM domain kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens LIM domain kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens LIM domain kinase 1 Kd nan None 10.1038/nbt1068
Homo sapiens LIM domain kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens LIM domain kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens LIM domain kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Liver glycogen phosphorylase Kd 2121.0 nM 10.1126/science.aan4368
Homo sapiens LNCaP IC50 16.0 nM 10.1021/jm0201520
Homo sapiens Long-chain-fatty-acid--CoA ligase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens LS174T IC50 65.0 nM 10.1021/jm0201520
Homo sapiens LX-1 IC50 75.0 nM 10.1021/jm0201520
Homo sapiens Macrophage colony stimulating factor receptor Kd 2800.0 nM 10.1038/nbt1358
Homo sapiens Macrophage colony stimulating factor receptor Kd 2800.0 nM 10.1038/nbt.1990
Homo sapiens Macrophage-stimulating protein receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Macrophage-stimulating protein receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase-activated protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase-activated protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase-activated protein kinase 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase-activated protein kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase ERK1 IC50 16000.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens MAP kinase ERK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase ERK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase ERK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase ERK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase ERK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase ERK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase p38 alpha Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase p38 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase p38 beta Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase p38 delta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 gamma Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase signal-integrating kinase 2 Kd 1900.0 nM 10.1038/nbt1068
Homo sapiens MAP kinase signal-integrating kinase 2 Kd 3200.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase signal-integrating kinase 2 Kd 3200.0 nM 10.1038/nbt.1990
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Maternal embryonic leucine zipper kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Maternal embryonic leucine zipper kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Maternal embryonic leucine zipper kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MCF7 Activity 74.0 % 10.1016/j.bmc.2010.06.046
Homo sapiens MCF7 GI50 92.0 nM 10.1016/j.ejmech.2021.113244
Homo sapiens MCF7 IC50 26.0 nM 10.1016/j.bmc.2006.10.063
Homo sapiens MCF7 IC50 66.0 nM 10.1021/jm0201520
Homo sapiens MCF7 IC50 500.0 nM 10.1016/s0960-894x(00)00156-6
Homo sapiens MDA-MB-231 Activity 16.47 % 10.1016/j.ejmech.2018.01.004
Homo sapiens MDA-MB-231 Activity 17.5 % 10.1016/j.ejmech.2018.01.004
Homo sapiens MDA-MB-231 Activity 66.03 % 10.1016/j.ejmech.2018.01.004
Homo sapiens MDA-MB-468 GI50 96.0 nM 10.1016/j.ejmech.2021.113244
Homo sapiens MIA PaCa-2 GI50 78.0 nM 10.1016/j.ejmech.2021.113244
Homo sapiens MIA PaCa-2 IC50 320.0 nM 10.1016/j.ejmech.2020.112355
Homo sapiens MIA PaCa-2 IC50 36000.0 nM 10.1021/jm000231g
Homo sapiens Microtubule-associated serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Midasin Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MIP IC50 120.0 nM 10.1021/jm0201520
Homo sapiens Misshapen-like kinase 1 Kd 1300.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase 15 Kd 330.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 15 Kd 330.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase 15 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase 7 Kd 620.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 7 Kd 620.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 10 Kd 5200.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 10 Kd 5200.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 12 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 13 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 15 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 2 Kd 6100.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 3 Kd 9900.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd nan None 10.1038/nbt1068
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Mitogen-activated protein kinase kinase kinase 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Kd 2900.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Kd 5700.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Kd 5700.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 3300.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 3300.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Kd 89.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 4500.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 4500.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mixed lineage kinase 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mixed lineage kinase 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mixed lineage kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MRC5 GI50 28.0 nM 10.1021/jm301475f
Homo sapiens MRC5 GI50 39.0 nM 10.1021/jm301475f
Homo sapiens MRC5 GI50 49.0 nM 10.1021/jm301475f
Homo sapiens MT4 IC50 67.0 nM 10.1039/c4md00412d
Homo sapiens Multifunctional protein ADE2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Muscle glycogen phosphorylase IC50 1000.0 nM 10.1021/jm031121n
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MV4-11 IC50 79.0 nM 10.1021/acs.jmedchem.1c00271
Homo sapiens Myosin-10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin-14 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin IIIA Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin IIIA Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin-IIIB Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin-IIIB Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin light chain kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin light chain kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens myosin light chain kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens myosin light chain kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens myosin light chain kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Myosin light chain kinase family member 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin light chain kinase family member 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin light chain kinase, smooth muscle Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myotonin-protein kinase Kd 650.0 nM 10.1038/nbt1358
Homo sapiens Myotonin-protein kinase Kd 650.0 nM 10.1038/nbt.1990
Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens NCI-H460 Activity 71.0 % 10.1016/j.bmcl.2012.04.008
Homo sapiens NCI-H460 Activity 78.0 % 10.1016/j.bmc.2010.06.046
Homo sapiens NCI-H460 Activity 84.0 % 10.1016/j.bmc.2009.12.077
Homo sapiens NCI-H460 Activity 88.0 % 10.1021/acsmedchemlett.7b00545
Homo sapiens NCI-H460 GI 84.0 % 10.1016/j.bmc.2009.11.066
Homo sapiens NCI-N87 IC50 111.0 nM 10.1016/j.ejmech.2020.112355
Homo sapiens Nerve growth factor receptor Trk-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Nerve growth factor receptor Trk-A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Nerve growth factor receptor Trk-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Nerve growth factor receptor Trk-A Kd nan None 10.1038/nbt1068
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens NT-3 growth factor receptor IC50 nan None 10.1021/acs.jmedchem.1c00271
Homo sapiens NT-3 growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NT-3 growth factor receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens NUAK family SNF1-like kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NUAK family SNF1-like kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens NUAK family SNF1-like kinase 2 Kd 1400.0 nM 10.1038/nbt1358
Homo sapiens NUAK family SNF1-like kinase 2 Kd 1400.0 nM 10.1038/nbt.1990
Homo sapiens NUAK family SNF1-like kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Nucleolar GTP-binding protein 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Nucleoside diphosphate kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Obg-like ATPase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens OVCAR-3 IC50 54.0 nM 10.1021/jm0201520
Homo sapiens PANC-1 Activity 74.0 % 10.1016/j.bmcl.2012.04.008
Homo sapiens PANC-1 Activity 75.0 % 10.1016/j.bmc.2009.12.077
Homo sapiens PANC-1 Activity 78.0 % 10.1021/acsmedchemlett.7b00545
Homo sapiens PANC-1 GI 68.0 % 10.1007/s00044-011-9834-7
Homo sapiens PANC-1 GI 75.0 % 10.1016/j.bmc.2009.11.066
Homo sapiens PAS domain-containing serine/threonine-protein kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens PC-3 Activity 77.0 % 10.1016/j.bmc.2010.06.046
Homo sapiens PC-3 IC50 66.0 nM 10.1021/jm0201520
Homo sapiens PC-3 IC50 110.0 nM 10.1016/j.ejmech.2020.112355
Homo sapiens PC-3 IC50 10000.0 nM 10.1021/jm000231g
Homo sapiens Peripheral plasma membrane protein CASK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Peroxisomal acyl-coenzyme A oxidase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Peroxisomal acyl-coenzyme A oxidase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens P-glycoprotein 1 Ratio 6.848 None 10.1021/acs.jmedchem.0c02011
Homo sapiens Phenylalanine--tRNA ligase beta subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylethanolamine-binding protein 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma Kd 2600.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma Kd 870.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma Kd 2845.0 nM 10.1126/science.aan4368
Homo sapiens Phosphofructokinase platelet type Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd 2200.0 nM 10.1038/nbt1358
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd 2200.0 nM 10.1038/nbt.1990
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd nan None 10.1038/nbt1068
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 2000.0 nM 10.1038/nbt1068
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 2900.0 nM 10.1038/nbt1358
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 2900.0 nM 10.1038/nbt.1990
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens PI3-kinase p110-alpha subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PI3-kinase p110-alpha subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PI3-kinase p110-beta subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PI3-kinase p110-delta subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PI3-kinase p110-gamma subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PI4-kinase beta subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Platelet-derived growth factor receptor alpha Kd 5900.0 nM 10.1038/nbt.1990
Homo sapiens Platelet-derived growth factor receptor alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Platelet-derived growth factor receptor beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Platelet-derived growth factor receptor beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Platelet-derived growth factor receptor beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Platelet-derived growth factor receptor beta Kd nan None 10.1038/nbt1068
Homo sapiens Probable ATP-dependent RNA helicase DDX6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C alpha IC50 1000.0 nM 10.1021/acs.jmedchem.1c00271
Homo sapiens Protein kinase C alpha IC50 2800.0 nM 10.1021/jm0201520
Homo sapiens Protein kinase C alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C alpha Kd nan None 10.1038/nbt1068
Homo sapiens Protein kinase C beta IC50 45000.0 nM 10.1021/jm0201520
Homo sapiens Protein kinase C beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C delta IC50 890.0 nM 10.1021/jm0201520
Homo sapiens Protein kinase C delta Kd 590.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C delta Kd 590.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C delta Kd 1592.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C epsilon IC50 480.0 nM 10.1021/jm0201520
Homo sapiens Protein kinase C epsilon Kd 380.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C epsilon Kd 380.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C eta IC50 45000.0 nM 10.1021/jm0201520
Homo sapiens Protein kinase C eta Kd 350.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C eta Kd 350.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C iota Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C iota Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C mu Kd 520.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C mu Kd 520.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C nu Kd 170.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C nu Kd 170.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C nu Kd 857.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C (PKC) IC50 6000.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens Protein kinase C (PKC) IC50 10000.0 nM 10.1016/s0960-894x(00)00156-6
Homo sapiens Protein kinase C (PKC) IC50 15000.0 nM 10.1021/jm0201520
Homo sapiens Protein kinase C theta Kd 350.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C theta Kd 350.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C theta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C zeta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase N1 Kd 3500.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase N1 Kd 3500.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase N1 Kd 9598.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase N2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase N2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase N2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein tyrosine kinase 2 beta Kd 3100.0 nM 10.1038/nbt.1990
Homo sapiens Protein tyrosine kinase 2 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein tyrosine kinase 2 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Kd 6800.0 nM 10.1038/nbt1358
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Kd 6800.0 nM 10.1038/nbt.1990
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Putative heat shock protein HSP 90-beta 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Putative uncharacterized serine/threonine-protein kinase SgK110 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Pyridoxal kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Quinone reductase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rab-like protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-27A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-6A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Receptor-interacting serine/threonine-protein kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Receptor-interacting serine/threonine-protein kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 15800.0 nM 10.1021/jm0201520
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd nan None 10.1038/nbt1068
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Kd 5000.0 nM 10.1038/nbt.1990
Homo sapiens Receptor tyrosine-protein kinase erbB-3 Kd 9200.0 nM 10.1038/nbt.1990
Homo sapiens Retinoblastoma-associated protein FC 0.9 None 10.1016/j.ejmech.2018.01.004
Homo sapiens Retinoblastoma-associated protein FC 1.0 None 10.1016/j.ejmech.2018.01.004
Homo sapiens Retinoblastoma-associated protein FC 1.1 None 10.1016/j.ejmech.2018.01.004
Homo sapiens Rho-associated protein kinase 1 Kd 1200.0 nM 10.1038/nbt.1990
Homo sapiens Rho-associated protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rho-associated protein kinase 2 Kd 1500.0 nM 10.1038/nbt.1990
Homo sapiens Rho-associated protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rhodopsin kinase Kd 650.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase 1 Kd 3700.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 720.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 720.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 2300.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 2300.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 2339.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 1500.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 1500.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 1600.0 nM 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 4300.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 1000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd nan None 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 1300.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 1300.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 2000.0 nM 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 800.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 800.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 2100.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens RNA cytidine acetyltransferase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens S-adenosylmethionine synthase isoform type-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens SEM EC50 204.3 nM 10.1016/j.ejmech.2018.01.004
Homo sapiens Septin-9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine-protein kinase ATR Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 10 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 10 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 10 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 11 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 11 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 16 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 16 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 16 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 16 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 17A Kd 4100.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 17A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 17A Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 17B Kd 1900.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 17B Kd 1900.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 17B Kd 5100.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 24 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 24 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 24 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 25 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 25 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 32A Kd 5500.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 32B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 32B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 32C Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 32C Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 33 Kd 1700.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 33 Kd 1700.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 35 Kd 450.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 36 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 36 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 36 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 38 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 38-like Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 38-like Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 38-like Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase AKT Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase AKT Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase A-Raf Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase B-raf Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase B-raf Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase B-raf Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Chk2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase D2 Kd 1100.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase D2 Kd 1100.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase D2 Kd 1316.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase DCLK1 Kd 2100.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK1 Kd 2100.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase DCLK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase DCLK3 Kd 1100.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK3 Kd 1100.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase GAK Kd 370.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase GAK Kd 370.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase GAK Kd 1100.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase GAK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ICK Kd 0.69 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ICK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ILK-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase LATS2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase LATS2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MAK Kd 28.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MARK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MARK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 9500.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 9500.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 14020.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 3300.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 3300.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 50005.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MST1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase MST2 Kd 9400.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST2 Kd 9400.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MST2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MST4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase mTOR Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase N3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek11 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase Nek3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Nek3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Nek5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Nek5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK6 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase NEK7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK9 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase NIM1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine protein kinase NLK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine protein kinase NLK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine protein kinase NLK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase OSR1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK6 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK7 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 180.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 440.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 440.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 1092.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 6.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 480.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 480.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PCTAIRE-3 Kd 1100.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-3 Kd 1100.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PFTAIRE-1 Kd 110.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PFTAIRE-1 Kd 110.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PFTAIRE-2 Kd 330.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 520.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 560.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 560.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 650.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 770.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 770.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PIM3 Kd 600.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM3 Kd 600.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PLK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 3100.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 8400.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PRKX Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PRKX Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PRP4 homolog Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RAF Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RAF Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase receptor R3 Kd 4500.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase receptor R3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIO1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIO1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIO2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIO3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIO3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase SBK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Sgk3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SIK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SIK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase SIK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SIK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase SRPK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SRPK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SRPK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SRPK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SRPK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TAO1 Kd 140.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TAO1 Kd 3255.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO2 Kd 250.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TAO2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO3 Kd 99.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TAO3 Kd 4310.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TBK1 Kd 470.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TBK1 Kd 1949.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TNNI3K Kd 55.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase TNNI3K Kd 55.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase tousled-like 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase tousled-like 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ULK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ULK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ULK2 Kd 470.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ULK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ULK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase VRK2 Kd 63.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Signal recognition particle receptor subunit alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens SK-BR-3 IC50 75.0 nM 10.1016/j.ejmech.2020.112355
Homo sapiens SK-BR-3 IC50 77.0 nM 10.1021/jm0201520
Homo sapiens SK-OV-3 IC50 220.0 nM 10.1016/j.ejmech.2020.112355
Homo sapiens SNF-related serine/threonine-protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens SPS1/STE20-related protein kinase YSK4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens STE20-related kinase adapter protein alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens STE20/SPS1-related proline-alanine-rich protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd 4600.0 nM 10.1016/j.ejmech.2011.02.057
Homo sapiens Stem cell growth factor receptor Kd 4600.0 nM 10.1038/nbt1358
Homo sapiens Stem cell growth factor receptor Kd 4600.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd 8800.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd 9000.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd 10000.0 nM 10.1016/j.ejmech.2011.02.057
Homo sapiens Stem cell growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Stem cell growth factor receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd nan None 10.1038/nbt1068
Homo sapiens Structural maintenance of chromosomes protein 1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Structural maintenance of chromosomes protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens SUP-B15 EC50 86206.9 nM 10.1016/j.ejmech.2018.01.004
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens TGF-beta receptor type I Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens TGF-beta receptor type I Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens TGF-beta receptor type I Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TGF-beta receptor type II Kd 5600.0 nM 10.1038/nbt1358
Homo sapiens TGF-beta receptor type II Kd 5600.0 nM 10.1038/nbt.1990
Homo sapiens TGF-beta receptor type II Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens THLE-2 EC50 nan None 10.1016/j.ejmech.2018.01.004
Homo sapiens Thyroid hormone receptor-associated protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TP53-regulating kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TRAF2- and NCK-interacting kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens TRAF2- and NCK-interacting kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens TRAF2- and NCK-interacting kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TRAF2- and NCK-interacting kinase Kd nan None 10.1038/nbt1068
Homo sapiens Transient receptor potential cation channel subfamily M member 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine kinase non-receptor protein 2 IC50 20000.0 nM 10.1021/acs.jmedchem.1c01030
Homo sapiens Tyrosine kinase non-receptor protein 2 Inhibition 74.0 % 10.1021/acs.jmedchem.1c01030
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL Kd 890.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 1200.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 1500.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 1600.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 1700.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 1900.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 2500.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 3100.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 3400.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 5900.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase ABL Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase ABL2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BLK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BLK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase BMX Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BMX Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase BMX Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BRK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BRK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase BRK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase BRK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BTK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BTK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase BTK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase BTK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase CSK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase CSK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase CSK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase CSK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase CTK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FER Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FER Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FER Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FER Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FES Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FES Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FES Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FGR Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FGR Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FGR Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FGR Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FRK Kd 1200.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FRK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FRK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FRK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FYN Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FYN Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FYN Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FYN Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase HCK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase HCK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase HCK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase HCK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ITK/TSK IC50 14850.0 nM 10.1021/jm0201520
Homo sapiens Tyrosine-protein kinase ITK/TSK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ITK/TSK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase JAK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase JAK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase JAK1 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase JAK2 Kd 5500.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase JAK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase JAK2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase JAK3 Kd 1600.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase JAK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase LCK IC50 11000.0 nM 10.1021/jm0201520
Homo sapiens Tyrosine-protein kinase LCK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase LCK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase LCK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase LCK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase Lyn Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase Lyn Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase Lyn Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase Lyn Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase receptor FLT3 IC50 nan None 10.1021/acs.jmedchem.1c00271
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 3200.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 3200.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 4600.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 4600.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 5000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 5000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 6500.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 6500.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase receptor RET Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor RET Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor RET Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase receptor Tie-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor Tie-1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor UFO Kd 3500.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor UFO Kd 3500.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase SRC IC50 34000.0 nM 10.1016/j.bmc.2019.01.027
Homo sapiens Tyrosine-protein kinase SRC Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase SRC Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase SRC Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase SRC Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase Srms Kd 1400.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase Srms Kd 1400.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase SYK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase SYK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase SYK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase SYK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase TEC Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TEC Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TEC Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase TIE-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TIE-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TIE-2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase TXK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TXK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TYK2 Kd 35.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TYK2 Kd 180.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TYK2 Kd 3468.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase TYK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase YES Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase YES Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase YES Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase YES Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ZAP-70 IC50 50000.0 nM 10.1021/jm0201520
Homo sapiens Tyrosine-protein kinase ZAP-70 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ZAP-70 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosyl-tRNA synthetase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens U2OS Activity nan None 10.1021/jm200064p
Homo sapiens U2OS Inhibition 62.0 % 10.1021/jm200064p
Homo sapiens U5 small nuclear ribonucleoprotein 200 kDa helicase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens UDP-glucuronosyltransferase 1-9 Km 37000.0 nM 10.1016/j.pharmthera.2004.10.013
Homo sapiens UDP-glucuronosyltransferase 1-9 Vmax 56.0 pmol/min/mg protein 10.1016/j.pharmthera.2004.10.013
Homo sapiens UMP-CMP kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized aarF domain-containing protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized aarF domain-containing protein kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Uncharacterized aarF domain-containing protein kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Uncharacterized protein FLJ45252 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens UoC-B1 EC50 208.4 nM 10.1016/j.ejmech.2018.01.004
Homo sapiens Vascular endothelial growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Vascular endothelial growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Vascular endothelial growth factor receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Vascular endothelial growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Vascular endothelial growth factor receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Wee1-like protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 15.0 nM 10.1039/c4md00412d
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 10.0 nM 10.1021/acs.jmedchem.0c01467
Influenza A virus Influenza A virus EC50 240.0 nM 10.1021/acs.jmedchem.0c01467
Influenza A virus Influenza A virus EC50 590.0 nM 10.1021/acs.jmedchem.0c01467
Influenza A virus Influenza A virus EC50 700.0 nM 10.1021/acs.jmedchem.0c01467
Influenza A virus Influenza A virus IC50 240.0 nM 10.1021/acs.jmedchem.0c01467
Mus musculus Dual specificity protein kinase CLK1 IC50 1300.0 nM 10.1021/jm201727w
Mus musculus M109 IC50 80.0 nM 10.1021/jm0201520
Mus musculus MLF IC50 72.0 nM 10.1021/jm0201520
Mus musculus Mus musculus Activity 0.03 nM min-1 (mg of protein)-1 10.1021/jm0201520
Mus musculus Mus musculus Activity 63.0 % 10.1021/jm0201520
Mus musculus Mus musculus AUC 5304.42 ng.hr.mL-1 10.1021/jm0201520
Mus musculus Mus musculus Binding 63.0 % 10.1021/jm0305568
Mus musculus Mus musculus Cmax 6900.0 nM 10.1021/jm0201520
Mus musculus Mus musculus LCK 1.5 None 10.1021/jm0305568
Mus musculus Mus musculus MRT 2.0 hr 10.1021/jm0201520
Mus musculus Mus musculus T1/2 1.1 hr 10.1021/jm0201520
Mus musculus Mus musculus Tmax 0.5 hr 10.1021/jm0201520
Mus musculus P388 MTD 7.5 mg kg-1 10.1021/jm0305568
Mus musculus P388 Survival 110.0 % 10.1021/jm0305568
Mus musculus P388 T/C 110.0 % 10.1021/jm0201520
Mus musculus Serine/threonine-protein kinase MST2 Kd nan None 10.1038/nbt1068
Mus musculus ULK3 kinase Kd nan None 10.1038/nbt1068
Mycobacterium tuberculosis Serine/threonine-protein kinase pknB Kd 10000.0 nM 10.1038/nbt.1990
Oryctolagus cuniculus Glycogen phosphorylase, muscle form IC50 1200.0 nM 10.1021/jm201439b
Plasmodium falciparum Calcium-dependent protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog Kd 3300.0 nM 10.1038/nbt.1990
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A IC50 300.0 nM 10.1021/jm201727w
Rattus norvegicus Protein kinase C (PKC) IC50 14000.0 nM 10.1021/jm000231g
Rattus norvegicus Tubulin alpha-1 chain Kd 10000.0 nM 10.1038/nbt1358
Saccharomyces cerevisiae Saccharomyces cerevisiae Activity nan None 10.1126/science.281.5376.533
Saccharomyces cerevisiae Saccharomyces cerevisiae FC 3.0 None 10.1126/science.281.5376.533
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 10000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Sus scrofa Glycogen synthase kinase-3 IC50 360.0 nM 10.1021/jm201727w
None ADMET CL 6.1 mL.min-1.kg-1 10.1124/dmd.108.020479
None ADMET Cp 14.0 ng/ml 10.1016/j.ejmech.2019.111813
None ADMET Ct 2.9 ng/ml 10.1016/j.ejmech.2019.111813
None ADMET Ct 5.6 ng/ml 10.1016/j.ejmech.2019.111813
None ADMET Ct 32.0 ng/ml 10.1016/j.ejmech.2019.111813
None ADMET Ct 52.0 ng/ml 10.1016/j.ejmech.2019.111813
None ADMET Ct 56.0 ng/ml 10.1016/j.ejmech.2019.111813
None ADMET Fu 0.021 None 10.1016/j.ejmech.2019.111813
None ADMET Fu 0.033 None 10.1016/j.ejmech.2019.111813
None ADMET Fu 0.0442 None 10.1016/j.ejmech.2019.111813
None ADMET Fu 0.051 None 10.1021/acs.jmedchem.0c02011
None ADMET Fu 0.057 None 10.1021/acs.jmedchem.0c02011
None ADMET Fu 0.0624 None 10.1016/j.ejmech.2019.111813
None ADMET Fu 0.147 None 10.1016/j.ejmech.2019.111813
None ADMET Fu 1.0 None 10.1016/j.ejmech.2019.111813
None ADMET K(p,uu,brain) 0.06 None 10.1016/j.ejmech.2019.111813
None ADMET K(p,uu,brain) 0.065 None 10.1016/j.ejmech.2019.111813
None ADMET K(p,uu,brain) 0.234 None 10.1021/acs.jmedchem.0c02011
None ADMET MRT 4.0 hr 10.1124/dmd.108.020479
None ADMET Papp 22.0 10'-6 cm/s 10.1016/j.ejmech.2019.111813
None ADMET Ratio 0.33 None 10.1016/j.ejmech.2019.111813
None ADMET Ratio 0.451 None 10.1021/acs.jmedchem.0c02011
None ADMET Ratio 0.86 None 10.1016/j.ejmech.2019.111813
None ADMET Ratio 1.7 None 10.1016/j.ejmech.2019.111813
None ADMET Ratio 2.7 None 10.1016/j.ejmech.2019.111813
None ADMET Ratio IC50/EC50 4.47 None 10.1039/c4md00412d
None ADMET Solubility 1291.0 ug.mL-1 10.1016/j.bmcl.2016.06.046
None ADMET Solubility 7378.0 ug.mL-1 10.1016/j.bmcl.2016.06.046
None ADMET T1/2 5.2 hr 10.1124/dmd.108.020479
None ADMET Vdss 1.5 L.kg-1 10.1124/dmd.108.020479
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Molecular identity unknown Activity 15.7 % 10.1007/s00044-011-9867-y
None Molecular identity unknown Activity 20.89 % 10.1007/s00044-011-9867-y
None Molecular identity unknown Activity 21.2 % 10.1007/s00044-011-9867-y
None Molecular identity unknown Activity 22.18 % 10.1007/s00044-011-9867-y
None Molecular identity unknown Activity 23.22 % 10.1007/s00044-011-9867-y
None Molecular identity unknown Activity 27.87 % 10.1007/s00044-011-9867-y
None Molecular identity unknown Activity 54.6 % 10.1007/s00044-011-9867-y
None Molecular identity unknown Activity 56.44 % 10.1007/s00044-011-9867-y
None Molecular identity unknown Activity 57.9 % 10.1007/s00044-011-9867-y
None Molecular identity unknown Activity nan None 10.1007/s00044-011-9867-y
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmcl.2011.05.019
None NON-PROTEIN TARGET CC50 120.0 nM 10.1021/acs.jmedchem.6b00150
None NON-PROTEIN TARGET EC50 34.0 nM 10.1021/acsmedchemlett.5b00278
None NON-PROTEIN TARGET EC50 59.0 nM 10.1021/acsmedchemlett.5b00278
None NON-PROTEIN TARGET Fu 0.06 None 10.1124/dmd.108.020479
None NON-PROTEIN TARGET GI 73.0 % 10.1007/s00044-011-9834-7
None NON-PROTEIN TARGET GI nan None 10.1007/s00044-011-9867-y
None NON-PROTEIN TARGET GI50 61.0 nM 10.1021/jm301475f
None NON-PROTEIN TARGET GI50 62.0 nM 10.1021/jm301475f
None NON-PROTEIN TARGET GI50 66.0 nM 10.1021/jm301475f
None NON-PROTEIN TARGET GI50 74.7 nM 10.1021/jm100732t
None NON-PROTEIN TARGET GI50 150.0 nM 10.1039/c4md00412d
None NON-PROTEIN TARGET GI50 180.0 nM 10.1039/c4md00412d
None NON-PROTEIN TARGET IC50 7.0 nM 10.1016/j.bmc.2006.10.063
None NON-PROTEIN TARGET IC50 200.0 nM 10.1007/s00044-011-9867-y
None NON-PROTEIN TARGET LC50 904.0 nM 10.1021/jm100732t
None No relevant target LogD 1.24 None 10.1016/j.bmcl.2016.06.046
None No relevant target LogP 0.21 None 10.1016/j.bmcl.2016.06.046
None No relevant target LogP 1.01 None 10.1016/j.bmcl.2016.06.046
None No relevant target LogP 1.14 None 10.1016/j.bmcl.2016.06.046
None No relevant target LogP 1.93 None 10.1016/j.bmcl.2016.06.046
None No relevant target pKa 5.56 None 10.1016/j.bmcl.2016.06.046
None No relevant target pKa 5.68 None 10.1016/j.bmcl.2016.06.046
None No relevant target Solubility 20.0 ug.mL-1 10.1021/acs.jmedchem.0c00744
None No relevant target Solubility 1141.0 ug.mL-1 10.1016/j.bmcl.2016.06.046
None No relevant target Solubility 1926.0 ug.mL-1 10.1016/j.bmcl.2016.06.046
None Unchecked Activity 14.28 % 10.1007/s00044-011-9867-y
None Unchecked Activity 16.0 % 10.1016/j.ejmech.2020.112355
None Unchecked Activity 61.0 % 10.1016/j.ejmech.2020.112355
None Unchecked Activity 70.0 % 10.1016/j.ejmech.2020.112355
None Unchecked Activity 78.0 % 10.1016/j.ejmech.2020.112355
None Unchecked Activity 100.0 % 10.1016/j.ejmech.2020.112355
None Unchecked Activity nan None 10.1016/j.ejmech.2022.114461
None Unchecked FC 0.0 None 10.1016/j.ejmech.2018.01.004
None Unchecked FC 0.4 None 10.1016/j.ejmech.2018.01.004
None Unchecked FC 0.6 None 10.1016/j.ejmech.2018.01.004
None Unchecked IC50 12.0 nM 10.1016/j.bmcl.2007.09.018
None Unchecked IC50 30.0 nM 10.1021/acs.jmedchem.1c02064
None Unchecked IC50 50.0 nM 10.1021/jm000231g
None Unchecked IC50 60.0 nM 10.1016/j.bmc.2019.01.027
None Unchecked IC50 60.0 nM 10.1021/acs.jmedchem.1c02064
None Unchecked IC50 90.0 nM 10.1021/jm201727w
None Unchecked IC50 100.0 nM 10.1021/acs.jmedchem.1c02064
None Unchecked IC50 170.0 nM 10.1016/j.ejmech.2022.114603
None Unchecked IC50 400.0 nM 10.1021/jm058013g
None Unchecked IC50 450.0 nM 10.1016/j.tips.2004.07.006
None Unchecked IC50 1000.0 nM 10.1039/C2MD20035J
None Unchecked IC50 13000.0 nM 10.1021/jm0201520
None Unchecked IC50 19000.0 nM 10.1021/jm000231g
None Unchecked IC50 50000.0 nM 10.1021/jm000231g
None Unchecked IC50 100000.0 nM 10.1021/jm0201520
None Unchecked IC50 122000.0 nM 10.1016/j.bmc.2019.01.027
None Unchecked Inhibition nan % 10.1016/j.ejmech.2022.114461
None Unchecked Kd 3104.0 nM 10.1126/science.aan4368
None Unchecked Kd 30000.0 nM 10.1126/science.aan4368
None Unchecked Ratio IC50 28.3 None 10.1039/c4md00412d

Metabolism Information