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Pleurothiazole

AlkaPlorer ID: AK112075

Synonym: 'Pleurothiazole'

IUPAC Name: (2S,5S,6S,9R,10S,13R,14S)-23-hydroxy-5-methyl-3-oxa-20-thia-18-azahexacyclo[14.7.0.02,9.06,10.09,14.017,21]tricosa-1(16),17(21),18,22-tetraene-13-carboxylic acid

Structure

SMILES: C[C@@H]1CO[C@@H]2C3=C(O)C=C4SC=NC4=C3C[C@H]3[C@H](C(=O)O)CC[C@H]4[C@@H]1CC[C@@]243

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InChI: InChI=1S/C22H25NO4S/c1-10-8-27-20-18-13(19-17(7-16(18)24)28-9-23-19)6-15-12(21(25)26)2-3-14-11(10)4-5-22(14,15)20/h7,9-12,14-15,20,24H,2-6,8H2,1H3,(H,25,26)/t10-,11-,12-,14+,15+,20-,22-/m1/s1

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InChIKey: VUPURRJSLQKYJL-POJXQBLJSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Hohenbuehelia grisea Hohenbuehelia Pleurotaceae Agaricales Agaricomycetes Basidiomycota Fungi Eukaryota

Properties Information

Molecule Weight: 399.5120000000002

TPSA？: 79.65

MolLogP？: 4.388800000000003

Number of H-Donors: 2

Number of H-Acceptors: 5

RingCount: 6

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus subtilis Bacillus subtilis Activity nan None 10.1021/acs.jnatprod.7b00713
Candida albicans Candida albicans Activity nan None 10.1021/acs.jnatprod.7b00713
Escherichia coli Escherichia coli Activity nan None 10.1021/acs.jnatprod.7b00713
Micrococcus luteus Micrococcus luteus Activity nan None 10.1021/acs.jnatprod.7b00713
Mucor hiemalis Mucor hiemalis Activity nan None 10.1021/acs.jnatprod.7b00713
Mucor plumbeus Mucor plumbeus Activity nan None 10.1021/acs.jnatprod.7b00713
Mycolicibacterium smegmatis Mycolicibacterium smegmatis Activity nan None 10.1021/acs.jnatprod.7b00713
Rhodotorula glutinis Rhodotorula glutinis MIC 33.3 ug.mL-1 10.1021/acs.jnatprod.7b00713
Schizosaccharomyces pombe Schizosaccharomyces pombe Activity nan None 10.1021/acs.jnatprod.7b00713
Staphylococcus aureus Staphylococcus aureus Activity nan None 10.1021/acs.jnatprod.7b00713
Wickerhamomyces anomalus Wickerhamomyces anomalus MIC 66.7 ug.mL-1 10.1021/acs.jnatprod.7b00713
Yamadazyma tenuis Yamadazyma tenuis MIC 100.0 ug.mL-1 10.1021/acs.jnatprod.7b00713

Metabolism Information