Arphamenin B
AlkaPlorer ID: AK112786
Synonym: 'Arphamenine B'
IUPAC Name: (2R,5S)-5-amino-8-(diaminomethylideneamino)-2-[(4-hydroxyphenyl)methyl]-4-oxooctanoic acid
Structure
SMILES: N=C(N)NCCC[C@H](N)C(=O)C[C@@H](CC1=CC=C(O)C=C1)C(=O)O
InChI: InChI=1S/C16H24N4O4/c17-13(2-1-7-20-16(18)19)14(22)9-11(15(23)24)8-10-3-5-12(21)6-4-10/h3-6,11,13,21H,1-2,7-9,17H2,(H,23,24)(H4,18,19,20)/t11-,13+/m1/s1
InChIKey: RRJCLYMGCZJLBQ-YPMHNXCESA-N
Reference
Arphamenines A and B,new inhibitors of aminopeptidase B,produced by bacteria.
PubChem CID: 5487163
LOTUS: LTS0033930
SuperNatural Ⅲ: SN0333203-04
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Chromobacterium violaceum | Chromobacterium | Chromobacteriaceae | Neisseriales | Betaproteobacteria | Pseudomonadota | None | Bacteria |
Properties Information
Molecule Weight: 336.39200000000005
TPSA？: 162.52
MolLogP？: 0.1852699999999998
Number of H-Donors: 6
Number of H-Acceptors: 5
RingCount: 1
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Rattus norvegicus | Aminopeptidase B | Ki | 0.84 | nM | 10.1021/jm00126a039 |
| Rattus norvegicus | Cystinyl aminopeptidase | Ki | 100.0 | ug ml-1 | 10.1021/jm00126a039 |