Bamipine
AlkaPlorer ID: AK115136
Synonym: None
IUPAC Name: N-benzyl-1-methyl-N-phenylpiperidin-4-amine
Structure
SMILES: CN1CCC(N(CC2=CC=CC=C2)C2=CC=CC=C2)CC1
InChI: InChI=1S/C19H24N2/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-11,19H,12-16H2,1H3
InChIKey: VZSXTYKGYWISGQ-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Piper nigrum | Piper | Piperaceae | Piperales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
| Piper hispidum | Piper | Piperaceae | Piperales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 280.41500000000013
TPSA？: 6.48
MolLogP？: 3.787400000000003
Number of H-Donors: 0
Number of H-Acceptors: 2
RingCount: 3
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Cavia porcellus | Histamine H1 receptor | pKb | 8.55 | None | 10.1016/j.bmc.2008.10.042 |
| Homo sapiens | HEK293 | LC50 | 64.08 | ug.mL-1 | 10.1016/j.bmc.2008.10.042 |
| Mycobacterium tuberculosis | Mycobacterium tuberculosis | Inhibition | 29.0 | % | 10.1016/j.bmc.2008.10.042 |
| Mycobacterium tuberculosis | Mycobacterium tuberculosis | MIC | 6.25 | ug.mL-1 | 10.1016/j.bmc.2008.10.042 |
| None | Unchecked | Ac50 | 1.0 | uM | None |
| None | Unchecked | Ac50 | 4.467 | uM | None |
| None | Unchecked | Ac50 | 7.079 | uM | None |
| None | Unchecked | Ac50 | 10.86 | uM | None |
| None | Unchecked | Ac50 | 15.34 | uM | None |
| None | Unchecked | AC50 | 1000.0 | nM | None |
| None | Unchecked | AC50 | 4466.8 | nM | None |
| None | Unchecked | AC50 | 7079.5 | nM | None |