Raistrickin
AlkaPlorer ID: AK119608
Synonym: None
IUPAC Name: 5,7-dihydroquinazolino[3,2-d][1,4]benzodiazepine-6,9-dione
Structure
SMILES: O=C1C2=CC=CC=C2N=C2C3=CC=CC=C3N=C(O)CN21
InChI: InChI=1S/C16H11N3O2/c20-14-9-19-15(10-5-1-3-7-12(10)17-14)18-13-8-4-2-6-11(13)16(19)21/h1-8H,9H2,(H,17,20)
InChIKey: WLCANJZBHABHMF-UHFFFAOYSA-N
Reference
Raistrickindole A, an Anti-HCV Oxazinoindole Alkaloid from <i>Penicillium raistrickii</i> IMB17-034
PubChem CID: 135666745
LOTUS: LTS0023728
NPASS: NPC483793
COCONUT: CNP0071549
{NPAtlas: NPA025138
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Penicillium raistrickii | Penicillium | Aspergillaceae | Eurotiales | Eurotiomycetes | Ascomycota | Fungi | Eukaryota |
Properties Information
Molecule Weight: 277.283
TPSA？: 67.47999999999999
MolLogP？: 2.6651
Number of H-Donors: 1
Number of H-Acceptors: 4
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Enterococcus faecalis | Enterococcus faecalis | MIC | 128.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00259 |
| Escherichia coli | Escherichia coli | MIC | 128.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00259 |
| Hepacivirus hominis | Hepatitis C virus | EC50 | 7000.0 | nM | 10.1021/acs.jnatprod.9b00259 |
| Homo sapiens | A549 | IC50 | 100000.0 | nM | 10.1021/acs.jnatprod.9b00259 |
| Homo sapiens | HCT-116 | IC50 | 100000.0 | nM | 10.1021/acs.jnatprod.9b00259 |
| Homo sapiens | NCI-H460 | IC50 | 100000.0 | nM | 10.1021/acs.jnatprod.9b00259 |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa | MIC | 128.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00259 |
| Staphylococcus aureus | Staphylococcus aureus | MIC | 128.0 | ug.mL-1 | 10.1021/acs.jnatprod.9b00259 |
| None | Unchecked | CC50 | 200000.0 | nM | 10.1021/acs.jnatprod.9b00259 |
| None | Unchecked | Ratio CC50/EC50 | 28.0 | None | 10.1021/acs.jnatprod.9b00259 |