Eudistidine A
AlkaPlorer ID: AK131280
Synonym: None
IUPAC Name: 10-(4-methoxyphenyl)-8,11,13,16-tetrazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),2,4,6,8,11,13-heptaen-10-ol
Structure
SMILES: COC1=CC=C(C2(O)N=C3N=CC=C4C5=CC=CC=C5N=C2N43)C=C1
InChI: InChI=1S/C19H14N4O2/c1-25-13-8-6-12(7-9-13)19(24)17-21-15-5-3-2-4-14(15)16-10-11-20-18(22-19)23(16)17/h2-11,24H,1H3
InChIKey: MDQMJPDAEWROBP-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| None | Eudistoma | Polycitoridae | Aplousobranchia | Ascidiacea | Chordata | Metazoa | Eukaryota |
| None | Eudistoma | Polycitoridae | Aplousobranchia | Ascidiacea | Chordata | Metazoa | Eukaryota |
Properties Information
Molecule Weight: 330.3470000000001
TPSA？: 69.77999999999999
MolLogP？: 2.681000000000001
Number of H-Donors: 1
Number of H-Acceptors: 6
RingCount: 5
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Histone acetyltransferase p300/Hypoxia-inducible factor 1-alpha | IC50 | 75000.0 | nM | 10.1016/j.bmc.2019.01.042 |
| Homo sapiens | Histone acetyltransferase p300/Hypoxia-inducible factor 1-alpha | IC50 | 75000.0 | nM | 10.1021/acs.jmedchem.8b01596 |