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4-[5-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-4-yl]pyridine

AlkaPlorer ID: AK132598

Synonym: None

IUPAC Name: 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine

Structure

SMILES: CS(=O)C1=CC=C(C2=NC(C3=CC=NC=C3)=C(C3=CC=C(F)C=C3)N2)C=C1

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InChI: InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)

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InChIKey: CDMGBJANTYXAIV-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Sinularia maxima Sinularia Sinulariidae Malacalcyonacea Anthozoa Cnidaria Metazoa Eukaryota

Properties Information

Molecule Weight: 377.444

TPSA？: 58.64

MolLogP？: 4.682200000000004

Number of H-Donors: 1

Number of H-Acceptors: 3

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Bacillus anthracis Anthrax lethal factor FC 4.3 None 10.1128/aac.01184-06
Bacillus anthracis Anthrax lethal factor Potency 12589.3 nM None
Bacillus anthracis Anthrax lethal factor Potency 31622.8 nM None
Bos taurus Progesterone receptor IC50 nan None None
Bos taurus Progesterone receptor Ki nan None None
Cavia porcellus Leukotriene C4 synthase IC50 nan None None
Cavia porcellus Leukotriene C4 synthase Ki nan None None
Cavia porcellus Serotonin 4 (5-HT4) receptor IC50 10553.0 nM None
Cavia porcellus Serotonin 4 (5-HT4) receptor Ki 1759.0 nM None
Gallus gallus Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt1358
Gallus gallus Tyrosine-protein kinase SRC Activity 73.0 % 10.1042/bj20070797
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 25118.9 nM None
Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD+] Potency 31622.8 nM None
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Activity 81.0 % 10.1042/bj20070797
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Ki 3981.07 nM None
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens A549 Activity nan None 10.1021/acs.jmedchem.8b01248
Homo sapiens Acetylcholinesterase IC50 nan None None
Homo sapiens Acetylcholinesterase Ki nan None None
Homo sapiens Activin receptor type-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Activin receptor type-1 Ki 3981.07 nM None
Homo sapiens Activin receptor type-1B Kd 3000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-1B Kd 3000.0 nM 10.1038/nbt.1990
Homo sapiens Activin receptor type-1B Residual Activity 23.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-1B Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-2A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-2A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Activin receptor type-2B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-2B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Adaptor-associated kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Adaptor-associated kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Adaptor-associated kinase Kd nan None 10.1038/nbt1068
Homo sapiens Adenosine A1 receptor IC50 2950.0 nM None
Homo sapiens Adenosine A1 receptor Ki 1721.0 nM None
Homo sapiens Adenosine A2a receptor IC50 6068.0 nM None
Homo sapiens Adenosine A2a receptor Ki 3407.0 nM None
Homo sapiens Adenosine A3 receptor IC50 nan None None
Homo sapiens Adenosine A3 receptor Ki nan None None
Homo sapiens Adhesion G-protein coupled receptor F1 %Inhib (Mean) -15.53 % 10.6019/CHEMBL5209801
Homo sapiens Adhesion G-protein coupled receptor F1 %Inhib (Mean) 0.23 % 10.6019/CHEMBL5209801
Homo sapiens Adhesion G-protein coupled receptor F1 %Inhib (Mean) 28.31 % 10.6019/CHEMBL5209801
Homo sapiens Adhesion G-protein coupled receptor F1 %Inhib (Mean) 35.28 % 10.6019/CHEMBL5209801
Homo sapiens Adhesion G-protein coupled receptor F1 %Max (Mean) -2.874 % 10.6019/CHEMBL5209801
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 28183.8 nM None
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 35481.3 nM None
Homo sapiens ALK tyrosine kinase receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens ALK tyrosine kinase receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens ALK tyrosine kinase receptor Ki 6309.57 nM None
Homo sapiens ALK tyrosine kinase receptor Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Alpha-1d adrenergic receptor IC50 nan None None
Homo sapiens Alpha-1d adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2a adrenergic receptor %Inhib (Mean) 15.92 % 10.6019/CHEMBL5209801
Homo sapiens Alpha-2a adrenergic receptor %Inhib (Mean) 26.05 % 10.6019/CHEMBL5209801
Homo sapiens Alpha-2a adrenergic receptor %Inhib (Mean) 30.84 % 10.6019/CHEMBL5209801
Homo sapiens Alpha-2a adrenergic receptor %Inhib (Mean) 48.8 % 10.6019/CHEMBL5209801
Homo sapiens Alpha-2a adrenergic receptor Ki nan None None
Homo sapiens Alpha-2a adrenergic receptor %Max (Mean) -4.6 % 10.6019/CHEMBL5209801
Homo sapiens Alpha-2b adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2b adrenergic receptor Ki nan None None
Homo sapiens Alpha-2c adrenergic receptor IC50 nan None None
Homo sapiens Alpha-2c adrenergic receptor Ki nan None None
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd nan None 10.1038/nbt1068
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Ki 3162.28 nM None
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Thermal melting change -0.9 degrees C 10.1073/pnas.0708800104
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Angiotensin II type 2 (AT-2) receptor IC50 nan None None
Homo sapiens Angiotensin II type 2 (AT-2) receptor Ki nan None None
Homo sapiens Ankyrin repeat and protein kinase domain-containing protein 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ankyrin repeat and protein kinase domain-containing protein 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Apelin receptor %Inhib (Mean) 37.71 % 10.6019/CHEMBL5209801
Homo sapiens Apelin receptor %Inhib (Mean) 48.63 % 10.6019/CHEMBL5209801
Homo sapiens Apelin receptor %Inhib (Mean) 51.27 % 10.6019/CHEMBL5209801
Homo sapiens Apelin receptor %Inhib (Mean) 59.98 % 10.6019/CHEMBL5209801
Homo sapiens Apelin receptor %Max (Mean) -3.352 % 10.6019/CHEMBL5209801
Homo sapiens Arachidonate 15-lipoxygenase Potency 19952.6 nM None
Homo sapiens Arachidonate 15-lipoxygenase, type II Potency 25118.9 nM None
Homo sapiens Arachidonate 5-lipoxygenase IC50 80.0 nM 10.1016/0960-894X(95)00189-Z
Homo sapiens Beta-1 adrenergic receptor IC50 nan None None
Homo sapiens Beta-1 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor IC50 nan None None
Homo sapiens Beta-2 adrenergic receptor %Inhib (Mean) 36.72 % 10.6019/CHEMBL5209801
Homo sapiens Beta-2 adrenergic receptor %Inhib (Mean) 58.93 % 10.6019/CHEMBL5209801
Homo sapiens Beta-2 adrenergic receptor %Inhib (Mean) 62.28 % 10.6019/CHEMBL5209801
Homo sapiens Beta-2 adrenergic receptor %Inhib (Mean) 65.7 % 10.6019/CHEMBL5209801
Homo sapiens Beta-2 adrenergic receptor Ki nan None None
Homo sapiens Beta-2 adrenergic receptor %Max (Mean) -4.19 % 10.6019/CHEMBL5209801
Homo sapiens Beta-3 adrenergic receptor IC50 nan None None
Homo sapiens Beta-3 adrenergic receptor Ki nan None None
Homo sapiens Blood IC50 190.0 nM 10.1016/j.bmcl.2011.05.114
Homo sapiens Blood IC50 1117.0 nM 10.1021/jm0496584
Homo sapiens Blood IC50 1760.0 nM 10.1021/jm100161q
Homo sapiens Blood IC50 1980.0 nM 10.1021/jm701529q
Homo sapiens Blood IC50 2300.0 nM 10.1021/jm701529q
Homo sapiens Blood IC50 2640.0 nM 10.1021/jm0496584
Homo sapiens Blood IC50 3018.0 nM 10.1021/acs.jmedchem.9b01227
Homo sapiens Blood IC50 3202.0 nM 10.1016/j.ejmech.2019.04.035
Homo sapiens Blood IC50 6400.0 nM 10.1016/j.bmcl.2009.06.094
Homo sapiens Blood Inhibition 76.5 % 10.1021/acs.jmedchem.9b01227
Homo sapiens BMP-2-inducible protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BMP-2-inducible protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens BMP-2-inducible protein kinase Kd nan None 10.1038/nbt1068
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Bone morphogenetic protein receptor type-1B Kd 3300.0 nM 10.1038/nbt.1990
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Bradykinin B2 receptor IC50 nan None None
Homo sapiens Bradykinin B2 receptor Ki nan None None
Homo sapiens Bromodomain-containing protein 4 Delta Tm 1.3 degrees C 10.1038/nrd.2016.266
Homo sapiens Bromodomain-containing protein 4 Delta TM 0.2165 C None
Homo sapiens Bromodomain-containing protein 4 Inhibition nan % 10.1021/acs.jmedchem.8b01248
Homo sapiens Bromodomain testis-specific protein Delta Tm 0.85 degrees C 10.1038/nrd.2016.266
Homo sapiens BR serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BR serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens BR serine/threonine-protein kinase 1 Ki 10000.0 nM None
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Activity 86.0 % 10.1042/bj20070797
Homo sapiens BR serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BR serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens C5a anaphylatoxin chemotactic receptor %Inhib (Mean) 17.78 % 10.6019/CHEMBL5209801
Homo sapiens C5a anaphylatoxin chemotactic receptor %Inhib (Mean) 18.71 % 10.6019/CHEMBL5209801
Homo sapiens C5a anaphylatoxin chemotactic receptor %Inhib (Mean) 41.88 % 10.6019/CHEMBL5209801
Homo sapiens C5a anaphylatoxin chemotactic receptor %Inhib (Mean) 57.31 % 10.6019/CHEMBL5209801
Homo sapiens C5a anaphylatoxin chemotactic receptor %Max (Mean) -6.354 % 10.6019/CHEMBL5209801
Homo sapiens Calcitonin receptor IC50 nan None None
Homo sapiens Calcitonin receptor Ki nan None None
Homo sapiens CaM kinase I alpha Activity 86.0 % 10.1042/bj20070797
Homo sapiens CaM kinase I alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase I alpha Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase I alpha Ki 6309.57 nM None
Homo sapiens CaM kinase I alpha Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I delta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase I delta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase I delta Ki 2511.89 nM None
Homo sapiens CaM kinase I delta Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 138.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase I gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase I gamma Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase I gamma Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase II alpha Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II alpha Ki 3981.07 nM None
Homo sapiens CaM kinase II alpha Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase II beta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II beta Ki 7943.28 nM None
Homo sapiens CaM kinase II beta Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II delta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase II delta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II delta Ki 6309.57 nM None
Homo sapiens CaM kinase II delta Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Thermal melting change -0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase II gamma Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II gamma Ki 6309.57 nM None
Homo sapiens CaM kinase II gamma Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase IV Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase IV Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM kinase IV Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM-kinase kinase alpha Activity 106.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM-kinase kinase alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM-kinase kinase alpha Kd nan None 10.1038/nbt1068
Homo sapiens CaM-kinase kinase beta Activity 99.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM-kinase kinase beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens CaM-kinase kinase beta Kd nan None 10.1038/nbt1068
Homo sapiens CaM-kinase kinase beta Ki 2511.89 nM None
Homo sapiens CaM-kinase kinase beta Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Activity 89.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Ki 2511.89 nM None
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens cAMP-dependent protein kinase (PKA) IC50 50000.0 nM 10.1021/jm9805236
Homo sapiens cAMP-dependent protein kinase (PKA) Inhibition 0.0 % 10.1021/jm980497b
Homo sapiens Cannabinoid CB1 receptor IC50 nan None None
Homo sapiens Cannabinoid CB1 receptor Ki nan None None
Homo sapiens Carbonic anhydrase II IC50 nan None None
Homo sapiens Carbonic anhydrase II Ki nan None None
Homo sapiens Casein kinase I alpha Kd 75.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I alpha Ki 316.23 nM None
Homo sapiens Casein kinase I delta Activity 8.0 % 10.1042/bj20070797
Homo sapiens Casein kinase I delta Delta TM 6.701 C None
Homo sapiens Casein kinase I delta IC50 120.0 nM 10.1021/jm9005127
Homo sapiens Casein kinase I delta IC50 124.0 nM 10.1021/jm049461b
Homo sapiens Casein kinase I delta IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens Casein kinase I delta Inhibition 92.0 % 10.1021/jm9005127
Homo sapiens Casein kinase I delta Kd 37.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I delta Kd 37.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I delta Ki 39.81 nM None
Homo sapiens Casein kinase I delta Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 11.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I epsilon IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens Casein kinase I epsilon Kd 100.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I epsilon Kd 100.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I epsilon Kd 220.0 nM 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I gamma 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I gamma 1 Kd nan None 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 1 Ki 6309.57 nM None
Homo sapiens Casein kinase I gamma 1 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Thermal melting change 0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase I gamma 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I gamma 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I gamma 2 Kd nan None 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 2 Ki 7943.28 nM None
Homo sapiens Casein kinase I gamma 2 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Thermal melting change 0.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase II Activity 98.0 % 10.1042/bj20070797
Homo sapiens Casein kinase II Inhibition 97.0 % 10.1042/0264-6021:3510095
Homo sapiens Casein kinase II Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase II alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase II alpha Ki 6309.57 nM None
Homo sapiens Casein kinase II alpha (prime) Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase II alpha (prime) Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase II alpha (prime) Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform alpha-like Kd 1700.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I isoform alpha-like Kd 1700.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I isoform gamma-3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I isoform gamma-3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Casein kinase I isoform gamma-3 Ki 6309.57 nM None
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 125.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Caspase-1 IC50 nan None None
Homo sapiens Caspase-1 Ki nan None None
Homo sapiens Cathepsin G IC50 nan None None
Homo sapiens Cathepsin G Ki nan None None
Homo sapiens C-C chemokine receptor type 2 IC50 nan None None
Homo sapiens C-C chemokine receptor type 2 Ki nan None None
Homo sapiens C-C chemokine receptor type 4 IC50 nan None None
Homo sapiens C-C chemokine receptor type 4 Ki nan None None
Homo sapiens C-C chemokine receptor type 5 IC50 nan None None
Homo sapiens C-C chemokine receptor type 5 Ki nan None None
Homo sapiens CDK3/cyclin E Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Cell division cycle 2-like protein kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cell division cycle 2-like protein kinase 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cell division cycle 7-related protein kinase Ki 1258.93 nM None
Homo sapiens Cell division protein kinase 8 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cell division protein kinase 8 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cell division protein kinase 8 Ki 3981.07 nM None
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens cGMP-dependent protein kinase 1 beta Ki 1995.26 nM None
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 125.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cGMP-dependent protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens cGMP-dependent protein kinase 2 Ki 1584.89 nM None
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cholecystokinin A receptor IC50 nan None None
Homo sapiens Cholecystokinin A receptor Ki nan None None
Homo sapiens Citron Rho-interacting kinase IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens Citron Rho-interacting kinase Kd 420.0 nM 10.1038/nbt1358
Homo sapiens Citron Rho-interacting kinase Kd 420.0 nM 10.1038/nbt.1990
Homo sapiens c-Jun N-terminal kinase 1 Activity 95.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 1 Inhibition 50.0 % 10.1016/s0960-894x(98)00495-8
Homo sapiens c-Jun N-terminal kinase 1 Inhibition 101.0 % 10.1042/0264-6021:3510095
Homo sapiens c-Jun N-terminal kinase 1 Kd 1100.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 1 Kd 1100.0 nM 10.1038/nbt.1990
Homo sapiens c-Jun N-terminal kinase 1 Kd 1200.0 nM 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 1 Ki 1258.93 nM None
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Activity 60.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 2 IC50 280.0 nM 10.1016/s0960-894x(98)00495-8
Homo sapiens c-Jun N-terminal kinase 2 IC50 290.0 nM 10.1021/jm9805236
Homo sapiens c-Jun N-terminal kinase 2 IC50 320.0 nM 10.1016/j.bmcl.2009.08.082
Homo sapiens c-Jun N-terminal kinase 2 IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens c-Jun N-terminal kinase 2 IC50 1900.0 nM 10.1021/jm9805236
Homo sapiens c-Jun N-terminal kinase 2 IC50 1920.0 nM 10.1016/s0960-894x(98)00495-8
Homo sapiens c-Jun N-terminal kinase 2 IC50 11000.0 nM 10.1021/jm049461b
Homo sapiens c-Jun N-terminal kinase 2 Inhibition 32.0 % 10.1021/jm701529q
Homo sapiens c-Jun N-terminal kinase 2 Kd 95.0 nM 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 2 Kd 130.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 2 Kd 130.0 nM 10.1038/nbt.1990
Homo sapiens c-Jun N-terminal kinase 2 Ki 199.53 nM None
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 30.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Activity 72.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 3 IC50 290.0 nM 10.1021/jm901392x
Homo sapiens c-Jun N-terminal kinase 3 IC50 720.0 nM 10.1021/acs.jmedchem.2c00799
Homo sapiens c-Jun N-terminal kinase 3 IC50 790.0 nM 10.1021/jm061097o
Homo sapiens c-Jun N-terminal kinase 3 IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens c-Jun N-terminal kinase 3 Inhibition 86.0 % 10.1021/jm701529q
Homo sapiens c-Jun N-terminal kinase 3 Kd 35.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 3 Kd 35.0 nM 10.1038/nbt.1990
Homo sapiens c-Jun N-terminal kinase 3 Kd 45.0 nM 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 3 Ki 25.12 nM None
Homo sapiens c-Jun N-terminal kinase 3 Ki 90.0 nM 10.1016/j.bmcl.2007.10.076
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 20.0 % 10.1042/bj20121418
Homo sapiens C-X3-C chemokine receptor 1 %Inhib (Mean) 13.92 % 10.6019/CHEMBL5209801
Homo sapiens C-X3-C chemokine receptor 1 %Inhib (Mean) 39.27 % 10.6019/CHEMBL5209801
Homo sapiens C-X3-C chemokine receptor 1 %Inhib (Mean) 51.4 % 10.6019/CHEMBL5209801
Homo sapiens C-X3-C chemokine receptor 1 %Inhib (Mean) 64.96 % 10.6019/CHEMBL5209801
Homo sapiens C-X3-C chemokine receptor 1 %Max (Mean) -1.649 % 10.6019/CHEMBL5209801
Homo sapiens Cyclin-dependent kinase 1 Ki 7943.28 nM None
Homo sapiens Cyclin-dependent kinase 13 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2 Delta TM 0.1409 C None
Homo sapiens Cyclin-dependent kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Cyclin-dependent kinase 2 Ki 7943.28 nM None
Homo sapiens Cyclin-dependent kinase 2 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 104.0 % 10.1042/bj20070797
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Cyclin-dependent kinase 5 Ki 3162.28 nM None
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 6 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 7 Ki 3981.07 nM None
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 9 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase 9 Ki 1584.89 nM None
Homo sapiens Cyclin-dependent kinase-like 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase-like 1 Thermal melting change -0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase-like 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase-like 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclin-dependent kinase-like 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Cyclooxygenase-1 IC50 2000.0 nM 10.1021/jm020427b
Homo sapiens Cyclooxygenase-1 IC50 5000.0 nM 10.1021/jm980497b
Homo sapiens Cyclooxygenase-1 IC50 nan None None
Homo sapiens Cyclooxygenase-1 Ki nan None None
Homo sapiens Cyclooxygenase-2 IC50 nan None None
Homo sapiens Cyclooxygenase-2 Ki nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 IC50 nan None None
Homo sapiens Cysteinyl leukotriene receptor 1 Ki nan None None
Homo sapiens Cytochrome P450 1A2 AC50 630.96 nM None
Homo sapiens Cytochrome P450 1A2 AC50 3981.07 nM None
Homo sapiens Cytochrome P450 1A2 IC50 2000.0 nM None
Homo sapiens Cytochrome P450 1A2 Inhibition 38.0 % 10.1021/jm701529q
Homo sapiens Cytochrome P450 1A2 Inhibition 61.0 % 10.1021/jm030766k
Homo sapiens Cytochrome P450 1A2 Inhibition 61.0 % 10.1021/jm0496584
Homo sapiens Cytochrome P450 1A2 Ki nan None None
Homo sapiens Cytochrome P450 2A6 IC50 nan None None
Homo sapiens Cytochrome P450 2A6 Ki nan None None
Homo sapiens Cytochrome P450 2C19 AC50 39.81 nM None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 IC50 800.0 nM None
Homo sapiens Cytochrome P450 2C19 Inhibition 85.0 % 10.1021/jm030766k
Homo sapiens Cytochrome P450 2C19 Inhibition 85.0 % 10.1021/jm0496584
Homo sapiens Cytochrome P450 2C19 Inhibition 92.0 % 10.1021/jm061072p
Homo sapiens Cytochrome P450 2C19 Inhibition 92.0 % 10.1021/jm701529q
Homo sapiens Cytochrome P450 2C19 Ki nan None None
Homo sapiens Cytochrome P450 2C19 Potency 39.8 nM None
Homo sapiens Cytochrome P450 2C9 AC50 1995.26 nM None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 IC50 1000.0 nM None
Homo sapiens Cytochrome P450 2C9 Inhibition 75.0 % 10.1021/jm030766k
Homo sapiens Cytochrome P450 2C9 Inhibition 75.0 % 10.1021/jm0496584
Homo sapiens Cytochrome P450 2C9 Inhibition 87.0 % 10.1021/jm701529q
Homo sapiens Cytochrome P450 2C9 Ki nan None None
Homo sapiens Cytochrome P450 2C9 Potency 1995.3 nM None
Homo sapiens Cytochrome P450 2D6 AC50 39810.72 nM None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 IC50 2000.0 nM None
Homo sapiens Cytochrome P450 2D6 Inhibition 67.0 % 10.1021/jm030766k
Homo sapiens Cytochrome P450 2D6 Inhibition 67.0 % 10.1021/jm0496584
Homo sapiens Cytochrome P450 2D6 Inhibition 73.0 % 10.1021/jm061072p
Homo sapiens Cytochrome P450 2D6 Inhibition 73.0 % 10.1021/jm701529q
Homo sapiens Cytochrome P450 2D6 Inhibition 78.0 % 10.1016/j.bmcl.2009.09.094
Homo sapiens Cytochrome P450 2D6 Ki nan None None
Homo sapiens Cytochrome P450 2D6 Potency 39810.7 nM None
Homo sapiens Cytochrome P450 2E1 IC50 nan None None
Homo sapiens Cytochrome P450 2E1 Ki nan None None
Homo sapiens Cytochrome P450 3A4 AC50 501.19 nM None
Homo sapiens Cytochrome P450 3A4 AC50 1258.93 nM None
Homo sapiens Cytochrome P450 3A4 IC50 nan None None
Homo sapiens Cytochrome P450 3A4 Inhibition 61.0 % 10.1021/jm030766k
Homo sapiens Cytochrome P450 3A4 Inhibition 61.0 % 10.1021/jm0496584
Homo sapiens Cytochrome P450 3A4 Inhibition 77.0 % 10.1021/jm061072p
Homo sapiens Cytochrome P450 3A4 Inhibition 77.0 % 10.1021/jm701529q
Homo sapiens Cytochrome P450 3A4 Ki nan None None
Homo sapiens Cytochrome P450 3A4 Potency 501.2 nM None
Homo sapiens Cytochrome P450 3A4 Potency 1258.9 nM None
Homo sapiens Death-associated protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Death-associated protein kinase 1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Death-associated protein kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Death-associated protein kinase 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Death-associated protein kinase 3 Kd nan None 10.1038/nbt1068
Homo sapiens Death-associated protein kinase 3 Ki 5011.87 nM None
Homo sapiens Death-associated protein kinase 3 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Thermal melting change -0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Delta opioid receptor IC50 nan None None
Homo sapiens Delta opioid receptor Ki nan None None
Homo sapiens Discoidin domain-containing receptor 2 Kd 5000.0 nM 10.1038/nbt1358
Homo sapiens Discoidin domain-containing receptor 2 Kd 5000.0 nM 10.1038/nbt.1990
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 46.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 12589.3 nM None
Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Potency 39810.7 nM None
Homo sapiens DNA polymerase kappa Potency 7943.3 nM None
Homo sapiens Dopamine D1 receptor IC50 nan None None
Homo sapiens Dopamine D1 receptor Ki nan None None
Homo sapiens Dopamine D2 receptor IC50 nan None None
Homo sapiens Dopamine D2 receptor Ki nan None None
Homo sapiens Dopamine D3 receptor IC50 nan None None
Homo sapiens Dopamine D3 receptor Ki nan None None
Homo sapiens Dopamine D4 receptor IC50 nan None None
Homo sapiens Dopamine D4 receptor Ki nan None None
Homo sapiens Dopamine transporter IC50 nan None None
Homo sapiens Dopamine transporter Ki nan None None
Homo sapiens Dual serine/threonine and tyrosine protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Activity 85.0 % 10.1042/bj20070797
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Inhibition 0.0 % 10.1021/jm701529q
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Ki 3162.28 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 9600.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 9600.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Ki 3981.07 nM None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 5 Kd 1400.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase; MEK1/2 IC50 61000.0 nM 10.1021/jm9805236
Homo sapiens Dual specificity protein kinase CLK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase CLK2 Kd nan None 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK2 Ki 3981.07 nM None
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity protein kinase CLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase CLK3 Kd nan None 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity protein kinase CLK4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase CLK4 Kd nan None 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK4 Ki 2511.89 nM None
Homo sapiens Dual specificity protein kinase TTK Kd 2500.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase TTK Kd 2500.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity protein kinase TTK Kd nan None 10.1038/nbt1068
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 84.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Ki 1995.26 nM None
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Ki 2511.89 nM None
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 97.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Activity 112.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Ki 6309.57 nM None
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 4 Ki 7943.28 nM None
Homo sapiens Dual specificty protein kinase CLK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificty protein kinase CLK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Dual specificty protein kinase CLK1 Kd nan None 10.1038/nbt1068
Homo sapiens Dual specificty protein kinase CLK1 Thermal melting change -0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 19952.6 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 31622.8 nM None
Homo sapiens Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Potency 39810.7 nM None
Homo sapiens Endothelin receptor ET-A IC50 nan None None
Homo sapiens Endothelin receptor ET-A Ki nan None None
Homo sapiens Ephrin type-A receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 1 Residual Activity 26.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 2 Ki 6309.57 nM None
Homo sapiens Ephrin type-A receptor 2 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 3 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 4 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 4 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 5 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 5 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 6 Kd 1200.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 6 Kd 1200.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 6 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 7 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 7 Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 8 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-A receptor 8 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 8 Residual Activity 43.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 1 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 1 Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 IC50 7800.0 nM 10.1021/jm0492204
Homo sapiens Ephrin type-B receptor 2 Inhibition 86.5 % 10.1021/jm0492204
Homo sapiens Ephrin type-B receptor 2 Kd 6800.0 nM 10.1021/jm0492204
Homo sapiens Ephrin type-B receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 2 Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 3 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ephrin type-B receptor 4 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 4 Residual Activity 41.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 6 Kd 3100.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 IC50 33000.0 nM 10.1016/j.bmcl.2004.08.007
Homo sapiens Epidermal growth factor receptor erbB1 IC50 96000.0 nM 10.1021/jm9805236
Homo sapiens Epidermal growth factor receptor erbB1 IC50 nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Kd 340.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 340.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 710.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 710.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1300.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1300.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1500.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1500.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1600.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1600.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1700.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1700.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1900.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 1900.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 2000.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 2000.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 2500.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Kd 2900.0 nM 10.1038/nbt1068
Homo sapiens Epidermal growth factor receptor erbB1 Kd 3200.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 3200.0 nM 10.1038/nbt.1990
Homo sapiens Epidermal growth factor receptor erbB1 Ki 1258.93 nM None
Homo sapiens Epidermal growth factor receptor erbB1 Ki nan None None
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity -1.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 1.0 % 10.1042/bj20121418
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 1000.0 nM 10.1038/nbt1358
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 1000.0 nM 10.1038/nbt.1990
Homo sapiens Estrogen receptor alpha IC50 nan None None
Homo sapiens Estrogen receptor alpha Ki nan None None
Homo sapiens Estrogen receptor beta IC50 nan None None
Homo sapiens Estrogen receptor beta Ki nan None None
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Fibroblast Growth Rate 0.0 None 10.6019/CHEMBL4689842
Homo sapiens Fibroblast Growth Rate 1.0 None 10.6019/CHEMBL4689842
Homo sapiens Fibroblast growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Fibroblast growth factor receptor 1 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 1 Ki 3981.07 nM None
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 142.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Fibroblast growth factor receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Delta TM 0.7492 C None
Homo sapiens Fibroblast growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Fibroblast growth factor receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 3 Ki 1995.26 nM None
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Focal adhesion kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Focal adhesion kinase 1 Kd nan None 10.1038/nbt1068
Homo sapiens Focal adhesion kinase 1 Ki 6309.57 nM None
Homo sapiens Focal adhesion kinase 1 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 125.0 % 10.1042/bj20121418
Homo sapiens Glucagon-like peptide 1 receptor %Inhib (Mean) 1.9 % 10.6019/CHEMBL5209801
Homo sapiens Glucagon-like peptide 1 receptor %Inhib (Mean) 27.36 % 10.6019/CHEMBL5209801
Homo sapiens Glucagon-like peptide 1 receptor %Inhib (Mean) 28.42 % 10.6019/CHEMBL5209801
Homo sapiens Glucagon-like peptide 1 receptor %Inhib (Mean) 46.53 % 10.6019/CHEMBL5209801
Homo sapiens Glucagon-like peptide 1 receptor %Max (Mean) -0.52 % 10.6019/CHEMBL5209801
Homo sapiens Glucagon receptor IC50 37.07 nM 10.1007/s00044-013-0801-3
Homo sapiens Glucagon receptor Inhibition 18.0 % 10.1016/s0960-894x(99)00081-5
Homo sapiens Glucocorticoid receptor IC50 nan None None
Homo sapiens Glucocorticoid receptor Ki nan None None
Homo sapiens Glucose-dependent insulinotropic receptor %Inhib (Mean) 7.21 % 10.6019/CHEMBL5209801
Homo sapiens Glucose-dependent insulinotropic receptor %Inhib (Mean) 28.84 % 10.6019/CHEMBL5209801
Homo sapiens Glucose-dependent insulinotropic receptor %Inhib (Mean) 43.38 % 10.6019/CHEMBL5209801
Homo sapiens Glucose-dependent insulinotropic receptor %Inhib (Mean) 70.66 % 10.6019/CHEMBL5209801
Homo sapiens Glucose-dependent insulinotropic receptor %Max (Mean) 1.857 % 10.6019/CHEMBL5209801
Homo sapiens Glycogen synthase kinase-3 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Glycogen synthase kinase-3 alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Glycogen synthase kinase-3 alpha Ki 3981.07 nM None
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 49.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Activity 34.0 % 10.1042/bj20070797
Homo sapiens Glycogen synthase kinase-3 beta Delta TM 5.443 C None
Homo sapiens Glycogen synthase kinase-3 beta Inhibition 34.0 % 10.1021/jm701529q
Homo sapiens Glycogen synthase kinase-3 beta Inhibition 66.0 % 10.1042/0264-6021:3510095
Homo sapiens Glycogen synthase kinase-3 beta Kd 1700.0 nM 10.1038/nbt1358
Homo sapiens Glycogen synthase kinase-3 beta Kd 1700.0 nM 10.1038/nbt.1990
Homo sapiens Glycogen synthase kinase-3 beta Ki 1584.89 nM None
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 34.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Thermal melting change 3.5 degrees C 10.1073/pnas.0708800104
Homo sapiens G-protein coupled receptor 120 %Inhib (Mean) 15.7 % 10.6019/CHEMBL5209801
Homo sapiens G-protein coupled receptor 120 %Inhib (Mean) 24.21 % 10.6019/CHEMBL5209801
Homo sapiens G-protein coupled receptor 120 %Inhib (Mean) 31.47 % 10.6019/CHEMBL5209801
Homo sapiens G-protein coupled receptor 120 %Inhib (Mean) 33.36 % 10.6019/CHEMBL5209801
Homo sapiens G-protein coupled receptor 120 %Max (Mean) -2.0 % 10.6019/CHEMBL5209801
Homo sapiens G-protein coupled receptor 35 %Inhib (Mean) 39.56 % 10.6019/CHEMBL5209801
Homo sapiens G-protein coupled receptor 35 %Max (Mean) 8.88 % 10.6019/CHEMBL5209801
Homo sapiens G protein-coupled receptor kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens G protein-coupled receptor kinase 5 Ki 3981.07 nM None
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens HEK-293T Growth Rate 0.0 None 10.6019/CHEMBL4689842
Homo sapiens Hepatocyte growth factor receptor Kd 7900.0 nM 10.1038/nbt.1990
Homo sapiens Hepatocyte growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Hepatocyte growth factor receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Hepatocyte growth factor receptor Ki 2511.89 nM None
Homo sapiens Hepatocyte growth factor receptor Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens HERG IC50 nan None None
Homo sapiens HERG Ki nan None None
Homo sapiens Histamine H1 receptor IC50 nan None None
Homo sapiens Histamine H1 receptor Ki nan None None
Homo sapiens Histamine H2 receptor IC50 nan None None
Homo sapiens Histamine H2 receptor Ki nan None None
Homo sapiens Histone deacetylase 6 Inhibition -42.06 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition -4.23 % 10.6019/CHEMBL4808148
Homo sapiens HL-60 Activity 0.0 % 10.1016/j.ejmech.2012.04.035
Homo sapiens HL-60 Activity 0.0 % 10.1016/j.ejmech.2013.05.020
Homo sapiens HL-60 IC50 8600.0 nM 10.1016/j.ejmech.2013.05.020
Homo sapiens HL-60 IC50 50500.0 nM 10.1016/j.ejmech.2012.04.035
Homo sapiens HL-60 IC50 52200.0 nM 10.1016/j.ejmech.2012.04.035
Homo sapiens HL-60 IC50 52200.0 nM 10.1016/j.ejmech.2013.05.020
Homo sapiens HL-60 Inhibition 8.4 % 10.1016/j.ejmech.2013.05.020
Homo sapiens HL-60 Inhibition 22.4 % 10.1016/j.ejmech.2012.04.035
Homo sapiens HL-60 Inhibition 50.6 % 10.1016/j.ejmech.2012.04.035
Homo sapiens HL-60 Inhibition 68.1 % 10.1016/j.ejmech.2013.05.020
Homo sapiens HMG-CoA reductase IC50 nan None None
Homo sapiens HMG-CoA reductase Ki nan None None
Homo sapiens Homeodomain-interacting protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 86.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Homeodomain-interacting protein kinase 2 Ki 3162.28 nM None
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 96.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Homeodomain-interacting protein kinase 4 Ki 7943.28 nM None
Homo sapiens Homo sapiens IC50 350.0 nM 10.1021/jm020873z
Homo sapiens Homo sapiens IC50 940.0 nM 10.1021/jm020873z
Homo sapiens Homo sapiens IC50 2000.0 nM 10.1016/j.bmcl.2004.08.007
Homo sapiens Homo sapiens IC50 4200.0 nM 10.1016/j.bmcl.2004.08.006
Homo sapiens Hormonally up-regulated neu tumor-associated kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens HUVEC Inhibition nan % 10.1016/j.bmcl.2014.01.034
Homo sapiens Inactive serine/threonine-protein kinase VRK3 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Ki 3981.07 nM None
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Activity 95.0 % 10.1042/bj20070797
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Ki 3162.28 nM None
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Ki 3162.28 nM None
Homo sapiens Insulin-like growth factor I receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin-like growth factor I receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Insulin-like growth factor I receptor Ki 1995.26 nM None
Homo sapiens Insulin-like growth factor I receptor Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Insulin receptor Kd nan None 10.1038/nbt1068
Homo sapiens Insulin receptor Ki 5011.87 nM None
Homo sapiens Insulin receptor Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 129.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin receptor-related protein Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Insulin receptor-related protein Residual Activity 56.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Interleukin-1 receptor-associated kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Interleukin-1 receptor-associated kinase 1 Ki 7943.28 nM None
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Interleukin-1 receptor-associated kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Interleukin-1 receptor-associated kinase 4 Ki 10000.0 nM None
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Interleukin-8 receptor A IC50 nan None None
Homo sapiens Interleukin-8 receptor A Ki nan None None
Homo sapiens Interleukin-8 receptor B IC50 nan None None
Homo sapiens Interleukin-8 receptor B Ki nan None None
Homo sapiens Janus Kinase (JAK) Activity nan None 10.1038/nchembio.2007.59
Homo sapiens Kappa opioid receptor IC50 nan None None
Homo sapiens Kappa opioid receptor Ki nan None None
Homo sapiens L132 CC50 10000.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Ki 2511.89 nM None
Homo sapiens Leukocyte common antigen IC50 nan None None
Homo sapiens Leukocyte common antigen Ki nan None None
Homo sapiens Leukocyte elastase IC50 nan None None
Homo sapiens Leukocyte elastase Ki nan None None
Homo sapiens Leukocyte tyrosine kinase receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Leukocyte tyrosine kinase receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Leukocyte tyrosine kinase receptor Ki 2511.89 nM None
Homo sapiens LIM domain kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens LIM domain kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens LIM domain kinase 1 Kd nan None 10.1038/nbt1068
Homo sapiens LIM domain kinase 1 Ki 6309.57 nM None
Homo sapiens LIM domain kinase 1 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens LIM domain kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Lipoxin A4 receptor %Inhib (Mean) 14.37 % 10.6019/CHEMBL5209801
Homo sapiens Lipoxin A4 receptor %Inhib (Mean) 16.23 % 10.6019/CHEMBL5209801
Homo sapiens Lipoxin A4 receptor %Inhib (Mean) 16.28 % 10.6019/CHEMBL5209801
Homo sapiens Lipoxin A4 receptor %Inhib (Mean) 20.59 % 10.6019/CHEMBL5209801
Homo sapiens Lipoxin A4 receptor %Max (Mean) -3.14 % 10.6019/CHEMBL5209801
Homo sapiens LNCaP Activity nan None 10.1021/jm100729b
Homo sapiens Lysine-specific demethylase 4D-like Potency 25118.9 nM None
Homo sapiens Lysine-specific demethylase 4D-like Potency 35481.3 nM None
Homo sapiens Macrophage colony stimulating factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Macrophage colony stimulating factor receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Macrophage colony stimulating factor receptor Ki 2511.89 nM None
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Macrophage-stimulating protein receptor Ki 3981.07 nM None
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Activity 84.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 2 Activity nan None 10.1016/j.bmcl.2007.10.036
Homo sapiens MAP kinase-activated protein kinase 2 Inhibition 15.0 % 10.1021/jm701529q
Homo sapiens MAP kinase-activated protein kinase 2 Inhibition 93.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase-activated protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase-activated protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase-activated protein kinase 2 Ki 7943.28 nM None
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 133.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Activity 120.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 3 Ki 10000.0 nM None
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Activity 96.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 5 Inhibition 112.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase-activated protein kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase-activated protein kinase 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase-activated protein kinase 5 Ki 1584.89 nM None
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 145.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Activity 89.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK1 IC50 nan None None
Homo sapiens MAP kinase ERK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase ERK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase ERK1 Ki nan None None
Homo sapiens MAP kinase ERK1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase ERK2 Activity 83.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 Delta TM -0.03532 C None
Homo sapiens MAP kinase ERK2 IC50 nan None None
Homo sapiens MAP kinase ERK2 Inhibition 22.0 % 10.1021/jm980497b
Homo sapiens MAP kinase ERK2 Inhibition 85.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase ERK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase ERK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase ERK2 Ki 7943.28 nM None
Homo sapiens MAP kinase ERK2 Ki nan None None
Homo sapiens MAP kinase ERK2 Potency 12589.3 nM None
Homo sapiens MAP kinase ERK2 Potency 25118.9 nM None
Homo sapiens MAP kinase ERK2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Activity 109.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 Activity nan None 10.1016/j.bmcl.2007.10.036
Homo sapiens MAP kinase p38 Activity nan None 10.1016/j.bmcl.2015.12.006
Homo sapiens MAP kinase p38 Activity nan None 10.1038/nchembio.2007.59
Homo sapiens MAP kinase p38 EC50 60.0 nM 10.1021/jm020057r
Homo sapiens MAP kinase p38 IC50 25.0 nM 10.1016/s0960-894x(98)00589-7
Homo sapiens MAP kinase p38 IC50 37.0 nM 10.1021/jm011098a
Homo sapiens MAP kinase p38 IC50 37.0 nM 10.1021/jm030766k
Homo sapiens MAP kinase p38 IC50 39.0 nM 10.1021/jm9805236
Homo sapiens MAP kinase p38 IC50 42.0 nM 10.1021/jm010493y
Homo sapiens MAP kinase p38 IC50 42.0 nM 10.1021/jm960415o
Homo sapiens MAP kinase p38 IC50 48.0 nM 10.1021/jm010493y
Homo sapiens MAP kinase p38 IC50 50.0 nM 10.1021/jm020427b
Homo sapiens MAP kinase p38 IC50 56.0 nM 10.1021/acs.jmedchem.1c00790
Homo sapiens MAP kinase p38 IC50 56.0 nM 10.1021/jm061061w
Homo sapiens MAP kinase p38 IC50 72.0 nM 10.1021/jm049968m
Homo sapiens MAP kinase p38 IC50 83.0 nM 10.1016/s0960-894x(98)00495-8
Homo sapiens MAP kinase p38 IC50 136.0 nM 10.1016/j.bmcl.2006.05.050
Homo sapiens MAP kinase p38 IC50 290.0 nM 10.1021/jm030766k
Homo sapiens MAP kinase p38 IC50 300.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens MAP kinase p38 IC50 350.0 nM 10.1021/jm011098a
Homo sapiens MAP kinase p38 IC50 350.0 nM 10.1021/jm030766k
Homo sapiens MAP kinase p38 IC50 360.0 nM 10.1021/jm011098a
Homo sapiens MAP kinase p38 IC50 500.0 nM 10.1016/j.bmc.2017.02.065
Homo sapiens MAP kinase p38 IC50 500.0 nM 10.1016/j.bmc.2019.02.027
Homo sapiens MAP kinase p38 IC50 590.0 nM 10.1021/jm011098a
Homo sapiens MAP kinase p38 IC50 590.0 nM 10.1021/jm030766k
Homo sapiens MAP kinase p38 IC50 940.0 nM 10.1021/jm011098a
Homo sapiens MAP kinase p38 IC50 940.0 nM 10.1021/jm030766k
Homo sapiens MAP kinase p38 IC50 1000.0 nM 10.1021/jm9805236
Homo sapiens MAP kinase p38 Inhibition 62.0 % 10.1016/j.bmc.2011.08.067
Homo sapiens MAP kinase p38 Inhibition nan % 10.1021/np500700z
Homo sapiens MAP kinase p38 Kd 10.0 nM 10.1021/jm020057r
Homo sapiens MAP kinase p38 alpha Activity 9.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Activity 75.0 % 10.1021/acsmedchemlett.8b00081
Homo sapiens MAP kinase p38 alpha Activity nan None 10.1016/j.bmcl.2007.07.016
Homo sapiens MAP kinase p38 alpha Activity nan None 10.1021/acs.jmedchem.6b01647
Homo sapiens MAP kinase p38 alpha Activity nan None 10.1021/jm801467h
Homo sapiens MAP kinase p38 alpha Delta Tm 6.8 degrees C 10.1021/acsmedchemlett.8b00081
Homo sapiens MAP kinase p38 alpha EC50 60.0 nM 10.1016/j.ejmech.2019.111684
Homo sapiens MAP kinase p38 alpha IC50 10.0 nM 10.1016/j.bmcl.2004.08.007
Homo sapiens MAP kinase p38 alpha IC50 15.0 nM 10.1021/jm101623p
Homo sapiens MAP kinase p38 alpha IC50 19.0 nM 10.1039/C0MD00228C
Homo sapiens MAP kinase p38 alpha IC50 20.0 nM 10.1016/j.bmcl.2004.08.006
Homo sapiens MAP kinase p38 alpha IC50 20.0 nM 10.1016/s0960-894x(00)00270-5
Homo sapiens MAP kinase p38 alpha IC50 20.0 nM 10.1016/s0960-894x(00)00272-9
Homo sapiens MAP kinase p38 alpha IC50 20.0 nM 10.1016/s0960-894x(00)00574-6
Homo sapiens MAP kinase p38 alpha IC50 20.0 nM 10.1016/s0960-894x(02)00238-x
Homo sapiens MAP kinase p38 alpha IC50 25.0 nM 10.1016/j.bmcl.2013.03.103
Homo sapiens MAP kinase p38 alpha IC50 25.0 nM 10.1038/nrd.2016.266
Homo sapiens MAP kinase p38 alpha IC50 30.0 nM 10.1021/jm061097o
Homo sapiens MAP kinase p38 alpha IC50 35.0 nM 10.1016/j.ejmech.2019.111624
Homo sapiens MAP kinase p38 alpha IC50 35.0 nM 10.1039/C2MD20089A
Homo sapiens MAP kinase p38 alpha IC50 37.0 nM 10.1021/jm300951u
Homo sapiens MAP kinase p38 alpha IC50 38.0 nM 10.1016/j.bmcl.2003.12.023
Homo sapiens MAP kinase p38 alpha IC50 38.0 nM 10.1021/jm049461b
Homo sapiens MAP kinase p38 alpha IC50 39.0 nM 10.1016/j.bmcl.2008.02.033
Homo sapiens MAP kinase p38 alpha IC50 39.0 nM 10.1016/j.bmcl.2010.06.102
Homo sapiens MAP kinase p38 alpha IC50 39.0 nM 10.1016/s0960-894x(98)00495-8
Homo sapiens MAP kinase p38 alpha IC50 40.0 nM 10.1016/j.bmcl.2014.01.034
Homo sapiens MAP kinase p38 alpha IC50 40.0 nM 10.1021/jm300327h
Homo sapiens MAP kinase p38 alpha IC50 40.0 nM 10.1021/jm9005127
Homo sapiens MAP kinase p38 alpha IC50 41.0 nM 10.1016/j.ejmech.2019.04.035
Homo sapiens MAP kinase p38 alpha IC50 44.0 nM 10.1021/jm100161q
Homo sapiens MAP kinase p38 alpha IC50 45.0 nM 10.1021/jm701343f
Homo sapiens MAP kinase p38 alpha IC50 48.0 nM 10.1016/j.bmc.2010.01.070
Homo sapiens MAP kinase p38 alpha IC50 48.0 nM 10.1016/j.bmcl.2005.05.107
Homo sapiens MAP kinase p38 alpha IC50 48.0 nM 10.1016/s0960-894x(01)00163-9
Homo sapiens MAP kinase p38 alpha IC50 48.0 nM 10.1021/jm301539x
Homo sapiens MAP kinase p38 alpha IC50 48.0 nM 10.1021/jm401276h
Homo sapiens MAP kinase p38 alpha IC50 48.0 nM 10.1021/jm901443h
Homo sapiens MAP kinase p38 alpha IC50 50.0 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens MAP kinase p38 alpha IC50 50.0 nM 10.1021/acs.jmedchem.2c00799
Homo sapiens MAP kinase p38 alpha IC50 50.0 nM 10.1021/jm801291f
Homo sapiens MAP kinase p38 alpha IC50 55.0 nM 10.1016/j.bmcl.2011.05.114
Homo sapiens MAP kinase p38 alpha IC50 62.0 nM 10.1021/jm701529q
Homo sapiens MAP kinase p38 alpha IC50 65.0 nM 10.1016/j.ejmech.2019.04.035
Homo sapiens MAP kinase p38 alpha IC50 68.0 nM 10.1021/jm061072p
Homo sapiens MAP kinase p38 alpha IC50 70.0 nM 10.1016/j.bmcl.2009.08.082
Homo sapiens MAP kinase p38 alpha IC50 72.0 nM 10.1016/j.bmcl.2005.05.107
Homo sapiens MAP kinase p38 alpha IC50 100.0 nM 10.1021/ml2001455
Homo sapiens MAP kinase p38 alpha IC50 159.0 nM None
Homo sapiens MAP kinase p38 alpha IC50 273.0 nM 10.1021/jm301539x
Homo sapiens MAP kinase p38 alpha IC50 290.0 nM 10.1016/j.bmcl.2005.08.038
Homo sapiens MAP kinase p38 alpha IC50 290.0 nM 10.1021/jm020873z
Homo sapiens MAP kinase p38 alpha IC50 462.0 nM 10.1021/jm0496584
Homo sapiens MAP kinase p38 alpha IC50 500.0 nM 10.1016/j.ejmech.2021.113277
Homo sapiens MAP kinase p38 alpha IC50 723.0 nM 10.1021/jm401276h
Homo sapiens MAP kinase p38 alpha IC50 1230.0 nM 10.1021/jm101623p
Homo sapiens MAP kinase p38 alpha IC50 2000.0 nM 10.1021/jm300327h
Homo sapiens MAP kinase p38 alpha IC50 6000.0 nM 10.1016/j.bmcl.2008.02.033
Homo sapiens MAP kinase p38 alpha IC50 6000.0 nM 10.1016/j.bmcl.2010.06.102
Homo sapiens MAP kinase p38 alpha IC50 7000.0 nM 10.1128/aac.00680-07
Homo sapiens MAP kinase p38 alpha IC50 136000.0 nM 10.1016/j.bmcl.2004.07.024
Homo sapiens MAP kinase p38 alpha Inhibition 2.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 alpha Inhibition 98.0 % 10.1021/jm701529q
Homo sapiens MAP kinase p38 alpha Ka 1.0 10'7/M.s 10.1021/acs.jmedchem.7b00745
Homo sapiens MAP kinase p38 alpha Kd 2.18 10'-1/s 10.1021/acs.jmedchem.7b00745
Homo sapiens MAP kinase p38 alpha Kd 4.1 nM 10.1016/j.bmcl.2010.04.097
Homo sapiens MAP kinase p38 alpha Kd 12.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 alpha Kd 12.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 alpha Kd 17.0 nM 10.1038/nbt1068
Homo sapiens MAP kinase p38 alpha Kd 21.7 nM 10.1021/acs.jmedchem.7b00745
Homo sapiens MAP kinase p38 alpha Ki 18.0 nM 10.1016/j.bmcl.2007.10.076
Homo sapiens MAP kinase p38 alpha Ki 19.95 nM None
Homo sapiens MAP kinase p38 alpha Ki 57.0 nM 10.1016/j.bmcl.2010.04.097
Homo sapiens MAP kinase p38 alpha Ki nan None None
Homo sapiens MAP kinase p38 alpha Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 5.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Selectivity 0.0242 None 10.1038/nbt1358
Homo sapiens MAP kinase p38 alpha T1/2 0.0008889 hr 10.1021/acs.jmedchem.7b00745
Homo sapiens MAP kinase p38 alpha TIME 0.001278 hr 10.1021/acs.jmedchem.7b00745
Homo sapiens MAP kinase p38 alpha Tm 56.8 degrees C 10.1021/acsmedchemlett.8b00081
Homo sapiens MAP kinase p38 beta Activity 13.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 beta IC50 12.0 nM 10.1038/nrd.2016.266
Homo sapiens MAP kinase p38 beta IC50 78.0 nM 10.1016/s0960-894x(98)00495-8
Homo sapiens MAP kinase p38 beta IC50 430.0 nM 10.1021/ml2001455
Homo sapiens MAP kinase p38 beta IC50 500.0 nM 10.1021/acs.jmedchem.6b00438
Homo sapiens MAP kinase p38 beta IC50 500.0 nM 10.1021/jm049461b
Homo sapiens MAP kinase p38 beta IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens MAP kinase p38 beta Inhibition 10.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 beta Inhibition 90.0 % 10.1021/jm701529q
Homo sapiens MAP kinase p38 beta Kd 70.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 beta Kd 70.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 beta Kd 250.0 nM 10.1038/nbt1068
Homo sapiens MAP kinase p38 beta Residual Activity 2.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Thermal melting change 9.6 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase p38 delta Activity 107.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 delta IC50 87600000.0 nM None
Homo sapiens MAP kinase p38 delta Inhibition 7.0 % 10.1021/jm701529q
Homo sapiens MAP kinase p38 delta Inhibition 93.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 delta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 delta Ki 7943.28 nM None
Homo sapiens MAP kinase p38 delta Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Activity 104.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 gamma Inhibition 4.0 % 10.1021/jm701529q
Homo sapiens MAP kinase p38 gamma Inhibition 46.0 % 10.1016/s0960-894x(98)00495-8
Homo sapiens MAP kinase p38 gamma Inhibition 96.0 % 10.1042/0264-6021:3510095
Homo sapiens MAP kinase p38 gamma Kd 1500.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 gamma Kd 1500.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase p38 gamma Kd 1700.0 nM 10.1038/nbt1068
Homo sapiens MAP kinase p38 gamma Ki 6309.57 nM None
Homo sapiens MAP kinase p38 gamma Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Activity 107.0 % 10.1042/bj20070797
Homo sapiens MAP kinase signal-integrating kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase signal-integrating kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP kinase signal-integrating kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase signal-integrating kinase 2 Ki 10000.0 nM None
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Ki 7943.28 nM None
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Ki 5011.87 nM None
Homo sapiens Maternal embryonic leucine zipper kinase Activity 83.0 % 10.1042/bj20070797
Homo sapiens Maternal embryonic leucine zipper kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Maternal embryonic leucine zipper kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Maternal embryonic leucine zipper kinase Ki 1995.26 nM None
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Matrix metalloproteinase-1 IC50 nan None None
Homo sapiens Matrix metalloproteinase-1 Ki nan None None
Homo sapiens Matrix metalloproteinase 9 IC50 nan None None
Homo sapiens Matrix metalloproteinase 9 Ki nan None None
Homo sapiens MCF7 IC50 nan None 10.1016/j.bmc.2019.02.027
Homo sapiens MDA-MB-231 IC50 nan None 10.1016/j.bmc.2019.02.027
Homo sapiens Melanocortin receptor 3 IC50 nan None None
Homo sapiens Melanocortin receptor 3 Ki nan None None
Homo sapiens Melanocortin receptor 4 IC50 nan None None
Homo sapiens Melanocortin receptor 4 Ki nan None None
Homo sapiens Melanocortin receptor 5 IC50 nan None None
Homo sapiens Melanocortin receptor 5 Ki nan None None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 39810.7 nM None
Homo sapiens Microtubule-associated serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Misshapen-like kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Misshapen-like kinase 1 Ki 2511.89 nM None
Homo sapiens Misshapen-like kinase 1 Residual Activity 63.0 % 10.1042/bj20121418
Homo sapiens Misshapen-like kinase 1 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase 15 Activity 93.0 % 10.1042/bj20070797
Homo sapiens Mitogen-activated protein kinase 15 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 15 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase 6 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 10 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 10 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 10 Ki 3162.28 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 12 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 13 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 15 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd nan None 10.1038/nbt1068
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 138.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase kinase kinase 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Ki 2511.89 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 3700.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 3700.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Ki 398.11 nM None
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Ki 7943.28 nM None
Homo sapiens Mixed lineage kinase 7 Kd 4400.0 nM 10.1038/nbt1358
Homo sapiens Mixed lineage kinase 7 Kd 4400.0 nM 10.1038/nbt.1990
Homo sapiens Mixed lineage kinase 7 Ki 7943.28 nM None
Homo sapiens Monoamine oxidase A IC50 nan None None
Homo sapiens Monoamine oxidase A Ki nan None None
Homo sapiens Mu opioid receptor IC50 nan None None
Homo sapiens Mu opioid receptor Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M1 IC50 10666.0 nM None
Homo sapiens Muscarinic acetylcholine receptor M1 Ki 2569.0 nM None
Homo sapiens Muscarinic acetylcholine receptor M2 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M2 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M3 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M4 Ki nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 IC50 nan None None
Homo sapiens Muscarinic acetylcholine receptor M5 Ki nan None None
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 143.0 % 10.1042/bj20121418
Homo sapiens Myelin transcription factor 1 Activity 5.0 % 10.1016/j.ejmech.2012.06.007
Homo sapiens Myelin transcription factor 1 IC50 nan None 10.1016/j.ejmech.2012.06.007
Homo sapiens Myosin IIIA Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin IIIA Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin-IIIB Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin-IIIB Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin light chain kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens myosin light chain kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens myosin light chain kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens myosin light chain kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Myosin light chain kinase family member 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin light chain kinase family member 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin light chain kinase, smooth muscle Activity 85.0 % 10.1042/bj20070797
Homo sapiens Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens Myotonin-protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myotonin-protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Myotonin-protein kinase Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Nerve growth factor receptor Trk-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Nerve growth factor receptor Trk-A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Nerve growth factor receptor Trk-A Kd nan None 10.1038/nbt1068
Homo sapiens Nerve growth factor receptor Trk-A Ki 2511.89 nM None
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 121.0 % 10.1042/bj20121418
Homo sapiens Neurokinin 1 receptor IC50 nan None None
Homo sapiens Neurokinin 1 receptor Ki nan None None
Homo sapiens Neurokinin 2 receptor IC50 nan None None
Homo sapiens Neurokinin 2 receptor Ki nan None None
Homo sapiens Neuropeptide Y receptor type 1 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 1 Ki nan None None
Homo sapiens Neuropeptide Y receptor type 2 IC50 nan None None
Homo sapiens Neuropeptide Y receptor type 2 Ki nan None None
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Ki 3981.07 nM None
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Norepinephrine transporter IC50 nan None None
Homo sapiens Norepinephrine transporter Ki nan None None
Homo sapiens NT-3 growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NT-3 growth factor receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens NT-3 growth factor receptor Ki 2511.89 nM None
Homo sapiens NUAK family SNF1-like kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NUAK family SNF1-like kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NUAK family SNF1-like kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens P2X purinoceptor 7 IC50 5000.0 nM 10.1016/j.bmcl.2015.06.001
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens PBMC IC50 25.0 nM 10.1021/jm980497b
Homo sapiens PBMC IC50 48.0 nM 10.1021/jm980497b
Homo sapiens PBMC IC50 160.0 nM 10.1021/jm980497b
Homo sapiens PBMC IC50 340.0 nM 10.1016/j.bmcl.2013.01.072
Homo sapiens PBMC IC50 1000.0 nM 10.1016/j.bmcl.2013.01.072
Homo sapiens PBMC IC50 10000.0 nM 10.1016/j.bmcl.2013.01.072
Homo sapiens PBMC Inhibition 40.0 % 10.1016/j.bmcl.2013.01.072
Homo sapiens PBMC Inhibition 80.0 % 10.1016/j.bmcl.2013.01.072
Homo sapiens PC-3 FC 0.721 None 10.1038/nchembio790
Homo sapiens PDZ-binding kinase Ki 10000.0 nM None
Homo sapiens PDZ-binding kinase Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Peregrin Delta TM 0.2971 C None
Homo sapiens Peripheral plasma membrane protein CASK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma Kd 2600.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphodiesterase 5A IC50 11476.0 nM None
Homo sapiens Phosphodiesterase 5A Ki nan None None
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd nan None 10.1038/nbt1068
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd nan None 10.1038/nbt1068
Homo sapiens Phosphorylase kinase gamma subunit 2 Ki 5011.87 nM None
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens PI3-kinase p110-alpha subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PI3-kinase p110-alpha subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PI3-kinase p110-beta subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PI3-kinase p110-delta subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PI3-kinase p110-gamma subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PI4-kinase beta subunit Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Platelet activating factor receptor IC50 nan None None
Homo sapiens Platelet activating factor receptor Ki nan None None
Homo sapiens Platelet-derived growth factor receptor alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Platelet-derived growth factor receptor alpha Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Platelet-derived growth factor receptor alpha Ki 3162.28 nM None
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Platelet-derived growth factor receptor beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Platelet-derived growth factor receptor beta Kd nan None 10.1038/nbt1068
Homo sapiens Platelet-derived growth factor receptor beta Ki 1995.26 nM None
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Activity 86.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C alpha IC50 nan None None
Homo sapiens Protein kinase C alpha Inhibition 11.0 % 10.1021/jm701529q
Homo sapiens Protein kinase C alpha Inhibition 89.0 % 10.1042/0264-6021:3510095
Homo sapiens Protein kinase C alpha Kd nan None 10.1038/nbt1068
Homo sapiens Protein kinase C alpha Ki nan None None
Homo sapiens Protein kinase C alpha Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C delta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C delta Ki 7943.28 nM None
Homo sapiens Protein kinase C delta Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C epsilon Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C epsilon Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 125.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C eta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C eta Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Ki 7943.28 nM None
Homo sapiens Protein kinase C gamma Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C iota Ki 5011.87 nM None
Homo sapiens Protein kinase C iota Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Activity 78.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C mu Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C mu Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C mu Residual Activity 66.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C nu Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C nu Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C nu Ki 3981.07 nM None
Homo sapiens Protein kinase C (PKC) IC50 75000.0 nM 10.1021/jm9805236
Homo sapiens Protein kinase C theta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C theta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase C theta Ki 2511.89 nM None
Homo sapiens Protein kinase C theta Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Activity 89.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C zeta Ki 7943.28 nM None
Homo sapiens Protein kinase C zeta Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase N1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase N2 Activity 95.0 % 10.1042/bj20070797
Homo sapiens Protein kinase N2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase N2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein kinase N2 Ki 7943.28 nM None
Homo sapiens Protein kinase N2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein tyrosine kinase 2 beta Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Protein tyrosine kinase 2 beta Ki 1584.89 nM None
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Ki 2511.89 nM None
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Putative uncharacterized serine/threonine-protein kinase SgK110 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Pyruvate dehydrogenase kinase isoform 1 Inhibition 89.0 % 10.1042/0264-6021:3510095
Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Receptor-interacting serine/threonine-protein kinase 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Receptor protein-tyrosine kinase erbB-2 IC50 18896.0 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd nan None 10.1038/nbt1068
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki 1258.93 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Ki nan None None
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Kd 4800.0 nM 10.1038/nbt.1990
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Ki 3981.07 nM None
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Receptor tyrosine-protein kinase erbB-3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Regulator of G-protein signaling 4 Potency 2993.5 nM None
Homo sapiens Rho-associated protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Rho-associated protein kinase 1 Ki 3981.07 nM None
Homo sapiens Rho-associated protein kinase 1 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Activity 73.0 % 10.1042/bj20070797
Homo sapiens Rho-associated protein kinase 2 Inhibition 23.0 % 10.1021/jm701529q
Homo sapiens Rho-associated protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Rho-associated protein kinase 2 Ki 5011.87 nM None
Homo sapiens Rho-associated protein kinase 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Rhodopsin kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase 1 Activity 80.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase 1 Inhibition 87.0 % 10.1042/0264-6021:3510095
Homo sapiens Ribosomal protein S6 kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase 1 Ki 6309.57 nM None
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Activity 52.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 320.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 320.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd nan None 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Activity 93.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd nan None 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 3 Ki 3981.07 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 4 Ki 1584.89 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Activity 91.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 5 Inhibition 86.0 % 10.1042/0264-6021:3510095
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd nan None 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 5 Ki 1995.26 nM None
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 250.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 250.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 10 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 10 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Thermal melting change 2.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 11 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 11 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 16 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 16 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 16 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 16 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 17A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 17A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 17A Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 17A Ki 3981.07 nM None
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 123.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 17B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 17B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 17B Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 2 Kd 3700.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 2 Kd 3700.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 2 Kd 4600.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 2 Ki 1995.26 nM None
Homo sapiens Serine/threonine-protein kinase 2 Thermal melting change 3.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 24 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 24 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 25 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 25 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 25 Thermal melting change 0.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 32A Kd 1300.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 32B Kd 2100.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 32B Kd 2100.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 32C Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 32C Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 33 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 33 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 35 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 36 IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens Serine/threonine-protein kinase 36 Kd 860.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 36 Kd 1300.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 36 Kd 1300.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 38 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 38 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 38-like Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 38-like Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase 38-like Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase AKT Activity 89.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT Inhibition 38.0 % 10.1021/jm701529q
Homo sapiens Serine/threonine-protein kinase AKT Inhibition 62.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase AKT Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase AKT Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Activity 90.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase AKT2 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase AKT3 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Delta TM 0.05675 C None
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase Aurora-A Ki 3981.07 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Activity 85.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Aurora-B Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Activity 92.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase B-raf IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens Serine/threonine-protein kinase B-raf Kd 530.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase B-raf Kd 530.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase B-raf Kd 710.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase B-raf Kd 710.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Chk1 Activity 66.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk1 Inhibition 95.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Chk1 Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Chk2 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase c-TAK1 Activity 98.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase c-TAK1 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase D2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase D2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase D2 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase DCLK1 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase DCLK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 132.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase EEF2K Activity 98.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase EEF2K Ki 3981.07 nM None
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase GAK Activity 25.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase GAK IC50 105.0 nM 10.1021/jm501759m
Homo sapiens Serine/threonine-protein kinase GAK IC50 135.0 nM 10.1021/jm049461b
Homo sapiens Serine/threonine-protein kinase GAK IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens Serine/threonine-protein kinase GAK Kd 19.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase GAK Kd 19.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase GAK Kd 39.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ICK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase LATS2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase LATS2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MAK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MARK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MARK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 6200.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 6200.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MRCK-A Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 2700.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 2700.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 400.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 400.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MST1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MST1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST2 Activity 86.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase MST2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MST2 Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change -0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase mTOR Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Nek11 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Activity 81.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase NEK2 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 118.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase Nek3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Nek4 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase Nek5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Nek5 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK6 Activity 98.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK6 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase NEK7 Activity 96.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase NEK9 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase NIM1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine protein kinase NLK IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens Serine/threonine protein kinase NLK Kd 25.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine protein kinase NLK Kd 25.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase OSR1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase OSR1 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 1 Ki 10000.0 nM None
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Activity 86.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 4 Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK6 Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK6 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK7 Activity 89.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK7 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PAK7 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Thermal melting change -0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PCTAIRE-3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PFTAIRE-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PFTAIRE-1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PFTAIRE-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 82.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PIM1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PIM1 Ki 6309.57 nM None
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Thermal melting change -2.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM2 Activity 97.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PIM2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PIM2 Ki 1584.89 nM None
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 125.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM3 Activity 81.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PIM3 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK1 Activity 97.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK1 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK3 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PLK4 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PLK4 Ki 3981.07 nM None
Homo sapiens Serine/threonine-protein kinase PLK4 Thermal melting change 0.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PRKX Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PRKX Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase PRKX Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRP4 homolog Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RAF IC50 330.0 nM 10.1016/j.bmcl.2008.02.068
Homo sapiens Serine/threonine-protein kinase RAF IC50 330.0 nM 10.1021/jm9805236
Homo sapiens Serine/threonine-protein kinase RAF IC50 370.0 nM 10.1016/s0960-894x(98)00495-8
Homo sapiens Serine/threonine-protein kinase RAF IC50 2000.0 nM 10.1021/jm049461b
Homo sapiens Serine/threonine-protein kinase RAF Inhibition 85.0 % 10.1021/jm701529q
Homo sapiens Serine/threonine-protein kinase RAF Kd 980.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RAF Kd 980.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 3.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase receptor R3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase receptor R3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIO1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIO1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIO2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIO2 Thermal melting change -0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase RIO3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIO3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIPK2 Activity 7.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase RIPK2 IC50 10.0 nM 10.1016/j.bmc.2015.09.038
Homo sapiens Serine/threonine-protein kinase RIPK2 IC50 16.0 nM 10.1021/jm049461b
Homo sapiens Serine/threonine-protein kinase RIPK2 IC50 200.0 nM 10.1016/j.bmc.2015.09.038
Homo sapiens Serine/threonine-protein kinase RIPK2 IC50 250.0 nM 10.1021/acs.jmedchem.6b00211
Homo sapiens Serine/threonine-protein kinase RIPK2 IC50 251.19 nM 10.1021/acs.jmedchem.6b00211
Homo sapiens Serine/threonine-protein kinase RIPK2 IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens Serine/threonine-protein kinase RIPK2 IC50 6310.0 nM 10.1021/acs.jmedchem.6b00211
Homo sapiens Serine/threonine-protein kinase RIPK2 K 0.0317 /s 10.1016/j.bmc.2015.09.038
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 24.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 24.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 2100.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase RIPK2 Ratio IC50 25.0 None 10.1021/acs.jmedchem.6b00211
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 21.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 24.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 T1/2 0.006667 hr 10.1016/j.bmc.2015.09.038
Homo sapiens Serine/threonine-protein kinase SBK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Sgk1 Activity 91.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Sgk1 Inhibition 83.0 % 10.1042/0264-6021:3510095
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SIK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 132.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SIK2 Ki 1000.0 nM None
Homo sapiens Serine/threonine-protein kinase SIK3 Kd 3900.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SRPK1 Activity 91.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase SRPK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SRPK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SRPK1 Ki 7943.28 nM None
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SRPK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TAO1 Ki 5011.87 nM None
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase TBK1 Ki 3162.28 nM None
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TNNI3K Kd 3500.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase TNNI3K Kd 3500.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase tousled-like 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase tousled-like 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ULK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK1 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase VRK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 117.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform IC50 nan None None
Homo sapiens Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Ki nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor IC50 nan None None
Homo sapiens Serotonin 2a (5-HT2a) receptor Ki nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor IC50 nan None None
Homo sapiens Serotonin 2b (5-HT2b) receptor Ki nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor IC50 nan None None
Homo sapiens Serotonin 2c (5-HT2c) receptor Ki nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor IC50 nan None None
Homo sapiens Serotonin 6 (5-HT6) receptor Ki nan None None
Homo sapiens Serotonin transporter IC50 nan None None
Homo sapiens Serotonin transporter Ki nan None None
Homo sapiens Sigma opioid receptor IC50 nan None None
Homo sapiens Sigma opioid receptor Ki nan None None
Homo sapiens SNF-related serine/threonine-protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Sphingosine 1-phosphate receptor Edg-1 %Inhib (Mean) 20.82 % 10.6019/CHEMBL5209801
Homo sapiens Sphingosine 1-phosphate receptor Edg-1 %Inhib (Mean) 26.16 % 10.6019/CHEMBL5209801
Homo sapiens Sphingosine 1-phosphate receptor Edg-1 %Inhib (Mean) 28.93 % 10.6019/CHEMBL5209801
Homo sapiens Sphingosine 1-phosphate receptor Edg-1 %Inhib (Mean) 47.4 % 10.6019/CHEMBL5209801
Homo sapiens Sphingosine 1-phosphate receptor Edg-1 %Max (Mean) -2.018 % 10.6019/CHEMBL5209801
Homo sapiens SPS1/STE20-related protein kinase YSK4 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens STE20/SPS1-related proline-alanine-rich protein kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd 10000.0 nM 10.1016/j.ejmech.2011.02.057
Homo sapiens Stem cell growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Stem cell growth factor receptor Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Stem cell growth factor receptor Kd nan None 10.1038/nbt1068
Homo sapiens Stem cell growth factor receptor Ki 3981.07 nM None
Homo sapiens Stem cell growth factor receptor Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens SW1353 IC50 50.0 nM 10.1016/s0960-894x(00)00270-5
Homo sapiens SW1353 IC50 50.0 nM 10.1016/s0960-894x(00)00272-9
Homo sapiens SW1353 IC50 50.0 nM 10.1016/s0960-894x(00)00574-6
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Ki 1584.89 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Ki 1584.89 nM None
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I IC50 6000.0 nM 10.1021/jm010493y
Homo sapiens TGF-beta receptor type I IC50 30000.0 nM 10.1016/j.bmcl.2003.09.028
Homo sapiens TGF-beta receptor type I Kd 7100.0 nM 10.1038/nbt1358
Homo sapiens TGF-beta receptor type I Kd 7100.0 nM 10.1038/nbt.1990
Homo sapiens TGF-beta receptor type I Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type II Kd 1800.0 nM 10.1038/nbt1358
Homo sapiens TGF-beta receptor type II Kd 1800.0 nM 10.1038/nbt.1990
Homo sapiens THP-1 IC50 16.0 nM 10.1016/j.bmcl.2008.02.033
Homo sapiens THP-1 IC50 20.0 nM 10.1016/j.ejmech.2019.111684
Homo sapiens THP-1 IC50 50.0 nM 10.1073/pnas.0708800104
Homo sapiens THP-1 IC50 72.0 nM 10.1016/j.bmcl.2005.03.007
Homo sapiens THP-1 IC50 72.0 nM 10.1016/j.bmcl.2006.05.050
Homo sapiens THP-1 IC50 72.0 nM 10.1016/s0960-894x(03)00238-5
Homo sapiens THP-1 IC50 72000.0 nM 10.1016/j.bmcl.2004.07.024
Homo sapiens Thromboxane-A synthase IC50 494.0 nM None
Homo sapiens Thromboxane-A synthase Ki nan None None
Homo sapiens Thyroid stimulating hormone receptor Potency 39810.7 nM None
Homo sapiens TRAF2- and NCK-interacting kinase IC50 1000.0 nM 10.1021/acs.jmedchem.9b00058
Homo sapiens TRAF2- and NCK-interacting kinase Kd 820.0 nM 10.1038/nbt1358
Homo sapiens TRAF2- and NCK-interacting kinase Kd 820.0 nM 10.1038/nbt.1990
Homo sapiens TRAF2- and NCK-interacting kinase Kd 1500.0 nM 10.1038/nbt1068
Homo sapiens TRAF2- and NCK-interacting kinase Thermal melting change 2.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Transcription intermediary factor 1-alpha Delta TM -1.063 C None
Homo sapiens Transient receptor potential cation channel subfamily M member 6 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Type-1 angiotensin II receptor %Inhib (Mean) 36.96 % 10.6019/CHEMBL5209801
Homo sapiens Type-1 angiotensin II receptor %Inhib (Mean) 49.46 % 10.6019/CHEMBL5209801
Homo sapiens Type-1 angiotensin II receptor %Inhib (Mean) 52.25 % 10.6019/CHEMBL5209801
Homo sapiens Type-1 angiotensin II receptor %Inhib (Mean) 55.1 % 10.6019/CHEMBL5209801
Homo sapiens Type-1 angiotensin II receptor %Max (Mean) -3.364 % 10.6019/CHEMBL5209801
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine kinase non-receptor protein 2 Ki 3981.07 nM None
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Delta TM 2.866 C None
Homo sapiens Tyrosine-protein kinase ABL Kd 2600.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 3900.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL Ki 3162.28 nM None
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ABL2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BLK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase BLK Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BMX Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase BMX Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 36.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Kd 3900.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BRK Kd 3900.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase BRK Kd 9000.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BRK Ki 2511.89 nM None
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 7.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BTK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase BTK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BTK Ki 6309.57 nM None
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Activity 69.0 % 10.1042/bj20070797
Homo sapiens Tyrosine-protein kinase CSK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase CSK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase CSK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CTK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase CTK Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase FER Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FER Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FER Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FER Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase FER Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FES Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FES Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase FES Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FGR Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FGR Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 51.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Kd 1800.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FRK Kd 1800.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FRK Kd 4400.0 nM 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FRK Ki 251.19 nM None
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 17.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN IC50 nan None None
Homo sapiens Tyrosine-protein kinase FYN Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FYN Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase FYN Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FYN Ki 3981.07 nM None
Homo sapiens Tyrosine-protein kinase FYN Ki nan None None
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 35.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase HCK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase HCK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase HCK Ki 3162.28 nM None
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 61.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ITK/TSK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ITK/TSK Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase JAK1 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase JAK1 Thermal melting change 2.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine-protein kinase JAK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase JAK2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase JAK2 Ki 2511.89 nM None
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase JAK3 Ki 5011.87 nM None
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK IC50 3450.0 nM 10.1021/jm9805236
Homo sapiens Tyrosine-protein kinase LCK IC50 nan None None
Homo sapiens Tyrosine-protein kinase LCK Inhibition 32.0 % 10.1042/0264-6021:3510095
Homo sapiens Tyrosine-protein kinase LCK Inhibition 55.0 % 10.1021/jm980497b
Homo sapiens Tyrosine-protein kinase LCK Inhibition 68.0 % 10.1021/jm701529q
Homo sapiens Tyrosine-protein kinase LCK Kd 2800.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase LCK Kd 2800.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase LCK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase LCK Ki 5011.87 nM None
Homo sapiens Tyrosine-protein kinase LCK Ki nan None None
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 27.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 32.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase Lyn Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase Lyn Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase Lyn Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 13.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase receptor FLT3 Ki 2511.89 nM None
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor RET Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor RET Ki 3162.28 nM None
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 46.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor Tie-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor Tie-1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Ki 3162.28 nM None
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor UFO Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase receptor UFO Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 122.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC IC50 5000.0 nM 10.1021/jm049461b
Homo sapiens Tyrosine-protein kinase SRC Inhibition 54.0 % 10.1021/jm980497b
Homo sapiens Tyrosine-protein kinase SRC Kd 5300.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase SRC Kd 5300.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase SRC Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase SRC Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Srms Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase Srms Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase Srms Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase SYK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase SYK Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase SYK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase SYK Ki 1584.89 nM None
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TEC Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 IC50 20000.0 nM 10.1016/j.bmcl.2007.06.068
Homo sapiens Tyrosine-protein kinase TIE-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TIE-2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TIE-2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Kd 4500.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TXK Kd 4500.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TYK2 Kd 2000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TYK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TYK2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase TYK2 Ki 1995.26 nM None
Homo sapiens Tyrosine-protein kinase YES Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase YES Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase YES Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase YES Potency 10909.6 nM None
Homo sapiens Tyrosine-protein kinase YES Residual Activity 45.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ZAP-70 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 14963.1 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 29855.4 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 33498.3 nM None
Homo sapiens U2OS Growth Rate 0.0 None 10.6019/CHEMBL4689842
Homo sapiens U2OS Growth Rate 1.0 None 10.6019/CHEMBL4689842
Homo sapiens Ubiquitin carboxyl-terminal hydrolase 1 Potency 56234.1 nM None
Homo sapiens Uncharacterized aarF domain-containing protein kinase 4 Kd 3100.0 nM 10.1038/nbt1358
Homo sapiens Uncharacterized aarF domain-containing protein kinase 4 Kd 3100.0 nM 10.1038/nbt.1990
Homo sapiens Vascular endothelial growth factor receptor 1 IC50 nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Vascular endothelial growth factor receptor 1 Ki 3981.07 nM None
Homo sapiens Vascular endothelial growth factor receptor 1 Ki nan None None
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 39.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Vascular endothelial growth factor receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Vascular endothelial growth factor receptor 2 Ki 2511.89 nM None
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 60.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt.1990
Homo sapiens Vascular endothelial growth factor receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Vascular endothelial growth factor receptor 3 Ki 6309.57 nM None
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Vasoactive intestinal polypeptide receptor 1 IC50 nan None None
Homo sapiens Vasoactive intestinal polypeptide receptor 1 Ki nan None None
Homo sapiens Vasopressin V1a receptor IC50 nan None None
Homo sapiens Vasopressin V1a receptor Ki nan None None
Homo sapiens Vitamin D receptor Potency 70794.6 nM None
Homo sapiens Wee1-like protein kinase 2 Kd 10000.0 nM 10.1038/nbt.1990
Human coronavirus 229E Human coronavirus 229E Activity 60.0 % 10.1021/acs.jmedchem.0c01467
Human coronavirus 229E Human coronavirus 229E Activity 60.0 % 10.1021/acs.jmedchem.1c00335
Middle East respiratory syndrome-related coronavirus Middle East respiratory syndrome-related coronavirus Activity 45.0 % 10.1021/acs.jmedchem.1c00302
Mus musculus MAP kinase p38 Inhibition nan % 10.1016/j.bmc.2022.116811
Mus musculus MAP kinase p38 Inhibition nan % 10.1021/np400565e
Mus musculus MAP kinase p38 alpha Kd 20.0 nM 10.1021/jm030121k
Mus musculus MAP kinase p38 alpha Tm 46.6 degrees C 10.1021/jm030121k
Mus musculus Mus musculus Activity 1.0 None 10.1016/s0960-894x(02)00238-x
Mus musculus Mus musculus Activity 13.0 ng ml-1 10.1016/s0960-894x(02)00238-x
Mus musculus Mus musculus Activity 38.0 ng ml-1 10.1016/s0960-894x(02)00238-x
Mus musculus Mus musculus Change -83.0 % 10.1021/jm960415o
Mus musculus Mus musculus ED50 10.0 mg.kg-1 10.1021/acs.jmedchem.1c00790
Mus musculus Mus musculus IC 0.63 None 10.1016/s0960-894x(02)00238-x
Mus musculus Mus musculus ID50 27.9 mg.kg-1 10.1016/j.bmcl.2009.06.094
Mus musculus Mus musculus Inhibition -1.4 % 10.1016/s0960-894x(02)00238-x
Mus musculus Mus musculus Inhibition 0.0 % 10.1016/j.bmcl.2004.08.006
Mus musculus Mus musculus Inhibition 47.0 % 10.1016/j.bmcl.2004.08.006
Mus musculus Mus musculus Inhibition 50.0 % 10.1016/j.bmcl.2004.08.006
Mus musculus Mus musculus Inhibition 65.4 % 10.1016/s0960-894x(02)00238-x
Mus musculus Mus musculus Inhibition 80.0 % 10.1016/s0960-894x(02)00238-x
Mus musculus Mus musculus IO 0.25 None 10.1016/s0960-894x(02)00238-x
Mus musculus Nitric oxide synthase, inducible IC50 nan None None
Mus musculus Nitric oxide synthase, inducible Ki nan None None
Mus musculus RAW264.7 Inhibition 53.0 % 10.1021/np500760v
Mus musculus RAW264.7 Inhibition nan % 10.1016/j.bmcl.2013.05.058
Mus musculus Serine/threonine-protein kinase MST2 Kd nan None 10.1038/nbt1068
Mus musculus Tyrosinase IC50 34.0 nM 10.1021/acs.jmedchem.7b00967
Mus musculus Tyrosine-protein kinase LCK Activity 56.0 % 10.1042/bj20070797
Mus musculus ULK3 kinase Kd nan None 10.1038/nbt1068
Mycobacterium tuberculosis Serine/threonine-protein kinase pknB Kd 10000.0 nM 10.1038/nbt.1990
Oryctolagus cuniculus Angiotensin-converting enzyme IC50 nan None None
Oryctolagus cuniculus Angiotensin-converting enzyme Ki nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase IC50 nan None None
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Ki nan None None
Plasmodium falciparum Calcium-dependent protein kinase 1 Kd 850.0 nM 10.1038/nbt.1990
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog Kd 10000.0 nM 10.1038/nbt.1990
Pneumocystis carinii Mitogen-activated protein kinase 2 IC50 105.0 nM 10.1021/acs.jmedchem.0c01467
Rattus norvegicus Aldose reductase IC50 nan None None
Rattus norvegicus Aldose reductase Ki nan None None
Rattus norvegicus Alpha-1a adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1a adrenergic receptor Ki nan None None
Rattus norvegicus Alpha-1b adrenergic receptor IC50 nan None None
Rattus norvegicus Alpha-1b adrenergic receptor Ki nan None None
Rattus norvegicus Androgen Receptor IC50 nan None None
Rattus norvegicus Androgen Receptor Ki nan None None
Rattus norvegicus Arachidonate 5-lipoxygenase IC50 58000.0 nM 10.1016/0960-894X(95)00189-Z
Rattus norvegicus Glycine receptor IC50 nan None None
Rattus norvegicus Glycine receptor Ki nan None None
Rattus norvegicus Insulin receptor IC50 nan None None
Rattus norvegicus Insulin receptor Ki nan None None
Rattus norvegicus Nitric-oxide synthase, brain IC50 nan None None
Rattus norvegicus Nitric-oxide synthase, brain Ki nan None None
Rattus norvegicus Nuclear factor erythroid 2-related factor 2 Activity nan None 10.1016/j.bmc.2011.01.059
Rattus norvegicus P2X purinoceptor 7 IC50 30000.0 nM 10.1016/j.bmcl.2015.06.001
Rattus norvegicus Rattus norvegicus ID50 80.0 mg kg-1 day-1 10.1016/s0960-894x(98)00495-8
Rattus norvegicus Rattus norvegicus Inhibition 37.0 % 10.1021/acs.jmedchem.6b01647
Rattus norvegicus Rattus norvegicus Inhibition 74.0 % 10.1016/s0960-894x(98)00495-8
Rattus norvegicus Rattus norvegicus Inhibition nan % 10.1016/j.ejmech.2012.05.006
Rattus norvegicus Rattus norvegicus Inhibition nan % 10.1021/acs.jmedchem.6b01647
Rattus norvegicus Rho-associated protein kinase 2 Inhibition 77.0 % 10.1042/0264-6021:3510095
Rattus norvegicus Serotonin 1a (5-HT1a) receptor IC50 nan None None
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Ki nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor IC50 nan None None
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Ki nan None None
Rattus norvegicus Tubulin alpha-1 chain Kd 10000.0 nM 10.1038/nbt1358
Schistosoma mansoni Schistosoma mansoni In vitro activity nan None 10.6019/CHEMBL5096127
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 9.655 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 24.88 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.92 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.02 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 0.28 % 10.6019/CHEMBL4495565
Toxoplasma gondii Mitogen-activated protein kinase 1 IC50 100.0 nM 10.1128/aac.00680-07
Toxoplasma gondii Toxoplasma gondii Activity 30.0 day 10.1128/aac.00680-07
Toxoplasma gondii Toxoplasma gondii IC50 2500.0 nM 10.1128/aac.00680-07
Toxoplasma gondii Toxoplasma gondii IC50 8500.0 nM 10.1128/aac.00680-07
None ADMET F 10.0 % 10.1021/acs.jmedchem.1c00790
None ADMET IC50 37.0 nM 10.1021/jm020873z
None ADMET IC50 190.0 nM 10.1016/j.bmcl.2004.08.006
None ADMET IC50 590.0 nM 10.1021/jm020873z
None NON-PROTEIN TARGET IC50 220.0 nM 10.1016/j.ejmech.2012.05.006
None NON-PROTEIN TARGET IC50 3450.0 nM 10.1021/np300490v
None NON-PROTEIN TARGET IC50 3500.0 nM 10.1021/np400492a
None NON-PROTEIN TARGET IC50 3530.0 nM 10.1016/j.bmcl.2011.09.129
None NON-PROTEIN TARGET IC50 3560.0 nM 10.1016/j.bmcl.2012.10.129
None NON-PROTEIN TARGET IC50 5000.0 nM 10.1016/j.bmcl.2013.01.032
None NON-PROTEIN TARGET IC50 5000.0 nM 10.1021/np400492a
None NON-PROTEIN TARGET IC50 5020.0 nM 10.1016/j.bmcl.2011.09.129
None NON-PROTEIN TARGET IC50 5210.0 nM 10.1021/np300490v
None NON-PROTEIN TARGET IC50 5670.0 nM 10.1016/j.bmcl.2012.10.129
None NON-PROTEIN TARGET IC50 7240.0 nM 10.1016/j.bmcl.2011.09.129
None NON-PROTEIN TARGET IC50 7370.0 nM 10.1016/j.bmcl.2012.10.129
None NON-PROTEIN TARGET IC50 7500.0 nM 10.1021/np400492a
None NON-PROTEIN TARGET IC50 7530.0 nM 10.1021/np300490v
None NON-PROTEIN TARGET Inhibition 84.3 % 10.1016/j.bmcl.2010.09.001
None NON-PROTEIN TARGET Potency 6853.0 nM None
None NON-PROTEIN TARGET Potency 14950.2 nM None
None NON-PROTEIN TARGET Potency 18821.2 nM None
None No relevant target CHI nan None 10.1021/jm801291f
None No relevant target CLogP 3.6 None 10.1016/s0960-894x(00)00574-6
None No relevant target LogD7.4 3.34 None 10.6019/CHEMBL3301361
None No relevant target solubility nan None 10.1021/jm801291f
None Platelet IC50 200.0 nM 10.1073/pnas.0708800104
None Unchecked Activity 80.0 % 10.1042/bj20070797
None Unchecked Activity 104.0 % 10.1042/bj20070797
None Unchecked Activity nan None 10.1016/j.bmcl.2013.03.103
None Unchecked Activity nan None 10.1128/aac.01184-06
None Unchecked FC 2.5 None 10.1021/acs.jmedchem.5b00446
None Unchecked IC50 34.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 37.0 nM 10.1016/s0960-894x(99)00081-5
None Unchecked IC50 42.0 nM 10.1016/j.bmcl.2007.06.068
None Unchecked IC50 50.0 nM 10.1021/acs.jmedchem.6b00438
None Unchecked IC50 70.0 nM 10.1021/jm049575n
None Unchecked IC50 100.0 nM 10.1016/j.bmc.2008.09.059
None Unchecked IC50 136.0 nM 10.1016/j.bmcl.2005.03.007
None Unchecked IC50 220.0 nM 10.1021/acsmedchemlett.7b00477
None Unchecked IC50 290.0 nM 10.1021/jm049575n
None Unchecked IC50 600.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 3500.0 nM 10.1021/acs.jnatprod.6b00698
None Unchecked IC50 5000.0 nM 10.1021/acs.jnatprod.6b00698
None Unchecked IC50 5923.0 nM None
None Unchecked IC50 7200.0 nM 10.1021/acs.jnatprod.6b00698
None Unchecked IC50 7800.0 nM 10.1021/jm049733a
None Unchecked IC50 11590.0 nM None
None Unchecked IC50 400000.0 nM 10.1021/jm020427b
None Unchecked IC50 nan None None
None Unchecked Inhibition 0.0 % 10.1021/jm701529q
None Unchecked Inhibition 4.0 % 10.1021/jm701529q
None Unchecked Inhibition 33.0 % 10.1021/jm980497b
None Unchecked Inhibition 70.0 % 10.1021/np400175b
None Unchecked Inhibition 73.0 % 10.1016/j.bmc.2011.08.067
None Unchecked Inhibition 83.0 % 10.1021/jm980497b
None Unchecked Inhibition 83.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 96.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 99.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition 104.0 % 10.1042/0264-6021:3510095
None Unchecked Inhibition nan % 10.1021/acs.jmedchem.6b01647
None Unchecked Inhibition nan % 10.1021/np400175b
None Unchecked Kd 6800.0 nM 10.1021/jm049733a
None Unchecked Ki 2026.0 nM None
None Unchecked Ki nan None None
None Unchecked Potency 2.6 nM None
None Unchecked Potency 2093.1 nM None
None Unchecked Potency 4685.9 nM None
None Unchecked Potency 7079.5 nM None
None Unchecked Potency 8912.5 nM None
None Unchecked Potency 12589.3 nM None
None Unchecked Potency 16626.1 nM None
None Unchecked Potency 19952.6 nM None
None Unchecked Potency 23485.0 nM None
None Unchecked Potency 25118.9 nM None
None Unchecked Potency 29565.9 nM None
None Unchecked Ratio 6.0 None 10.1016/j.bmcl.2013.03.103

Metabolism Information