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name Structure Reference Source Properties Activities Metabolism

Seliciclib

AlkaPlorer ID: AK135000

Synonym: None

IUPAC Name: (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol

Structure

SMILES: CC[C@H](CO)N=C1N=C2C(=C(NCC3=CC=CC=C3)N1)N=CN2C(C)C

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InChI: InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1

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InChIKey: BTIHMVBBUGXLCJ-OAHLLOKOSA-N

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Reference

PubChem CID: 160355

CAS: 186692-46-6

NPASS: NPC469975

Properties Information

Molecule Weight: 354.4580000000001

TPSA？: 91.12

MolLogP？: 2.624000000000001

Number of H-Donors: 3

Number of H-Acceptors: 6

RingCount: 3

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Acinetobacter baumannii Acinetobacter baumannii MIC 20000.0 nM 10.6019/CHEMBL4513161
Bos taurus Cyclin-dependent kinase 5 IC50 200.0 nM 10.1021/acs.jmedchem.1c02190
Bos taurus Synapsin-1 IC50 1000.0 nM 10.1021/acs.jmedchem.6b00078
Candida albicans Candida albicans MIC 20000.0 nM 10.6019/CHEMBL4513161
Cryptococcus neoformans Cryptococcus neoformans MIC 20000.0 nM 10.6019/CHEMBL4513161
Escherichia coli Escherichia coli MIC 20000.0 nM 10.6019/CHEMBL4513161
Gallus gallus Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt1358
Gallus gallus Tyrosine-protein kinase SRC Activity 89.0 % 10.1042/bj20070797
Homo sapiens 26S protease regulatory subunit 6B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Activity 80.0 % 10.1042/bj20070797
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens 697 IC50 12600.71 nM 10.6019/CHEMBL1201861
Homo sapiens 786-0 GI50 23280.91 nM None
Homo sapiens 786-0 GI50 25100.0 nM 10.1021/jm801340z
Homo sapiens 786-0 GI50 79432.82 nM 10.1021/jm801340z
Homo sapiens 786-0 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens 786-0 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens 8-MG-BA IC50 167901.08 nM 10.6019/CHEMBL1201861
Homo sapiens A101D IC50 18320.78 nM 10.6019/CHEMBL1201861
Homo sapiens A253 cell line IC50 271299.4 nM 10.6019/CHEMBL1201861
Homo sapiens A2780 GI50 4450.0 nM 10.1016/j.bmc.2011.08.051
Homo sapiens A2780 GI50 12500.0 nM 10.1016/j.bmc.2011.08.051
Homo sapiens A-375 Activity 0.189 % 10.1016/j.ejmech.2020.112322
Homo sapiens A-375 Activity 7.03 % 10.1016/j.ejmech.2020.112322
Homo sapiens A-375 Activity 42.3 % 10.1016/j.ejmech.2020.112322
Homo sapiens A-375 Activity 50.5 % 10.1016/j.ejmech.2020.112322
Homo sapiens A-375 IC50 11790.0 nM 10.1016/j.ejmech.2020.112322
Homo sapiens A388 IC50 466316.23 nM 10.6019/CHEMBL1201861
Homo sapiens A3-KAW IC50 5761.16 nM 10.6019/CHEMBL1201861
Homo sapiens A498 GI50 25118.86 nM 10.1021/jm801340z
Homo sapiens A498 GI50 48083.93 nM None
Homo sapiens A498 GI50 50100.0 nM 10.1021/jm801340z
Homo sapiens A498 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens A498 TGI 79432.82 nM 10.1021/jm801340z
Homo sapiens A498 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens A4-Fuk IC50 258377.84 nM 10.6019/CHEMBL1201861
Homo sapiens A549 Activity 5.26 % 10.1016/j.bmcl.2013.03.129
Homo sapiens A549 Activity 7.3 % 10.1016/j.bmcl.2013.03.129
Homo sapiens A549 Activity 40.69 % 10.1016/j.bmcl.2013.03.129
Homo sapiens A549 Activity 46.75 % 10.1016/j.bmcl.2013.03.129
Homo sapiens A549 Activity nan None 10.1016/j.bmcl.2013.03.129
Homo sapiens A549 FC 4.0 None 10.1016/j.bmcl.2013.03.129
Homo sapiens A549 GI50 12589.25 nM 10.1021/jm801340z
Homo sapiens A549 GI50 12600.0 nM 10.1021/jm801340z
Homo sapiens A549 GI50 13645.83 nM None
Homo sapiens A549 GI50 15000.0 nM 10.1021/jm100732t
Homo sapiens A549 IC50 2180.0 nM 10.1016/j.bmcl.2013.03.129
Homo sapiens A549 IC50 10000.0 nM 10.1016/j.bmcl.2019.06.059
Homo sapiens A549 IC50 14140.0 nM 10.1016/j.bmcl.2012.08.117
Homo sapiens A549 IC50 14700.0 nM 10.1021/jm100080z
Homo sapiens A549 IC50 nan ug.mL-1 10.1016/s0960-894x(00)00014-7
Homo sapiens A549 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens A549 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens ACHN GI50 12600.0 nM 10.1021/jm801340z
Homo sapiens ACHN GI50 12823.31 nM None
Homo sapiens ACHN GI50 50118.72 nM 10.1021/jm801340z
Homo sapiens ACHN IC50 2880.0 nM 10.1016/j.bmcl.2013.03.129
Homo sapiens ACHN LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens ACHN TGI 79400.0 nM 10.1021/jm801340z
Homo sapiens ACHN TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens ACN IC50 21338.95 nM 10.6019/CHEMBL1201861
Homo sapiens Actin-related protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Actin-related protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-1B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Activin receptor type-2A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-2B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Activin receptor type-2B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acyl-CoA dehydrogenase family member 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Acyl-CoA dehydrogenase family member 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adaptor-associated kinase Delta TM -0.21 C None
Homo sapiens Adaptor-associated kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Adaptor-associated kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adaptor-associated kinase Kd nan None 10.1038/nbt1068
Homo sapiens Adenine phosphoribosyltransferase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adenosine kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Adenylate kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ADP/ATP translocase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ADP/ATP translocase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Aldehyde dehydrogenase 1A1 Potency 199.5 nM None
Homo sapiens ALK tyrosine kinase receptor Kd 2300.0 nM 10.1038/nbt1358
Homo sapiens ALL-PO IC50 143212.28 nM 10.6019/CHEMBL1201861
Homo sapiens AM-38 IC50 486181.98 nM 10.6019/CHEMBL1201861
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, alpha-1 subunit Kd nan None 10.1038/nbt1068
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens AMP-activated protein kinase, alpha-2 subunit Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens AMP-activated protein kinase, gamma-1 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens AMP-activated protein kinase, gamma-2 subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ankyrin repeat and protein kinase domain-containing protein 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens ARH-77 IC50 96021.87 nM 10.6019/CHEMBL1201861
Homo sapiens ASPC1 IC50 17767.0 nM 10.1016/j.bmcl.2018.10.020
Homo sapiens ATN-1 IC50 81680.39 nM 10.6019/CHEMBL1201861
Homo sapiens ATP-dependent RNA helicase DDX1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DDX3X Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ATP-dependent RNA helicase DDX42 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Aurora kinase A/B Ratio 0.11 None 10.1016/j.ejmech.2013.01.021
Homo sapiens BB30-HNC IC50 29948.34 nM 10.6019/CHEMBL1201861
Homo sapiens BB49-HNC IC50 85068.26 nM 10.6019/CHEMBL1201861
Homo sapiens BB65-RCC IC50 9974.95 nM 10.6019/CHEMBL1201861
Homo sapiens BC-3 IC50 18030.54 nM 10.6019/CHEMBL1201861
Homo sapiens BE-13 IC50 259090.91 nM 10.6019/CHEMBL1201861
Homo sapiens Becker IC50 9460.82 nM 10.6019/CHEMBL1201861
Homo sapiens BJ Activity 106.3 % 10.1016/j.bmcl.2015.04.030
Homo sapiens BL-41 IC50 25959.74 nM 10.6019/CHEMBL1201861
Homo sapiens BL-70 IC50 20327.36 nM 10.6019/CHEMBL1201861
Homo sapiens BMP-2-inducible protein kinase Delta TM -0.32 C None
Homo sapiens BMP-2-inducible protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BMP-2-inducible protein kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens BMP-2-inducible protein kinase Kd nan None 10.1038/nbt1068
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Bone morphogenetic protein receptor type-1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-1B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bone morphogenetic protein receptor type-2 Delta TM 0.44 C None
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Bone morphogenetic protein receptor type-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Brain glycogen phosphorylase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Breakpoint cluster region protein Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Bromodomain-containing protein 4 Delta TM -3.12 C None
Homo sapiens Bromodomain-containing protein 4 Delta TM -0.1799 C None
Homo sapiens BR serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BR serine/threonine-protein kinase 2 Activity 79.0 % 10.1042/bj20070797
Homo sapiens BR serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens BT-474 IC50 569912.59 nM 10.6019/CHEMBL1201861
Homo sapiens BT-549 GI50 nan None 10.1021/jm801340z
Homo sapiens BT-549 LC50 nan None 10.1021/jm801340z
Homo sapiens BT-549 TGI nan None 10.1021/jm801340z
Homo sapiens BV-173 IC50 2125913.77 nM 10.6019/CHEMBL1201861
Homo sapiens BXPC-3 IC50 15284.0 nM 10.1016/j.bmcl.2018.10.020
Homo sapiens C2BBe1 IC50 70477.75 nM 10.6019/CHEMBL1201861
Homo sapiens C8166 IC50 1143513.71 nM 10.6019/CHEMBL1201861
Homo sapiens CA46 IC50 92430.78 nM 10.6019/CHEMBL1201861
Homo sapiens Caco-2 Activity 45.0 % 10.1016/j.bmc.2017.01.049
Homo sapiens Caco-2 Activity 46.0 % 10.1016/j.bmc.2017.01.049
Homo sapiens Caco-2 Activity 90.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens Caco-2 Activity nan None 10.1016/j.bmc.2017.01.049
Homo sapiens Caco-2 Activity_index 0.0 None 10.1016/j.bmc.2017.01.049
Homo sapiens Caco-2 Activity_index 1.7 None 10.1016/j.bmc.2017.01.049
Homo sapiens Caco-2 IC50 3000.0 nM 10.1016/j.ejmech.2015.06.046
Homo sapiens Caco-2 IC50 5000.0 nM 10.1016/j.ejmech.2012.09.001
Homo sapiens Caco-2 IC50 6000.0 nM 10.1016/j.bmc.2009.07.051
Homo sapiens Caco-2 IC50 10000.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens Caco-2 IC50 10000.0 nM 10.1016/j.ejmech.2011.08.048
Homo sapiens Caco-2 IC50 12900.0 nM 10.1016/j.bmc.2017.01.049
Homo sapiens Caco-2 IC50 14000.0 nM 10.1016/j.bmcl.2021.128390
Homo sapiens Caco-2 IC50 16000.0 nM 10.1021/acs.jnatprod.5b01073
Homo sapiens Caco-2 IC50 17000.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens CAKI-1 GI50 6165.95 nM None
Homo sapiens CAKI-1 GI50 6300.0 nM 10.1021/jm801340z
Homo sapiens CAKI-1 GI50 12589.25 nM 10.1021/jm801340z
Homo sapiens CAKI-1 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens CAKI-1 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens CAL-148 IC50 10000.0 nM 10.1016/j.bmcl.2019.06.059
Homo sapiens CAL-148 IC50 181377.41 nM 10.6019/CHEMBL1201861
Homo sapiens Calu-6 IC50 32474.53 nM 10.6019/CHEMBL1201861
Homo sapiens CaM kinase I alpha Activity 104.0 % 10.1042/bj20070797
Homo sapiens CaM kinase I alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I alpha Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase I delta Delta TM -2.98 C None
Homo sapiens CaM kinase I delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I delta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase I delta Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase I gamma Delta TM -0.96 C None
Homo sapiens CaM kinase I gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase I gamma Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase I gamma Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II alpha Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II alpha Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II beta Delta TM -0.25 C None
Homo sapiens CaM kinase II beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II beta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II beta Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II delta Delta TM -0.16 C None
Homo sapiens CaM kinase II delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase II delta Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II delta Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase II gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase II gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase II gamma Kd nan None 10.1038/nbt1068
Homo sapiens CaM kinase II gamma Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM kinase IV Delta TM 0.17 C None
Homo sapiens CaM kinase IV Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM kinase IV Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM kinase IV Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens CaM-kinase kinase alpha Activity 73.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM-kinase kinase alpha Kd nan None 10.1038/nbt1068
Homo sapiens CaM-kinase kinase beta Activity 71.0 % 10.1042/bj20070797
Homo sapiens CaM-kinase kinase beta Delta TM 2.73 C None
Homo sapiens CaM-kinase kinase beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CaM-kinase kinase beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CaM-kinase kinase beta Kd nan None 10.1038/nbt1068
Homo sapiens CaM-kinase kinase beta Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Activity 73.0 % 10.1042/bj20070797
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cAMP-dependent protein kinase beta-1 catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase, gamma catalytic subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cAMP-dependent protein kinase (PKA) IC50 1000000.0 nM 10.1016/j.bmcl.2004.01.050
Homo sapiens cAMP-dependent protein kinase (PKA) IC50 1000000.0 nM 10.1021/jm011002c
Homo sapiens cAMP-dependent protein kinase type II-alpha regulatory subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CAS-1 IC50 994666.0 nM 10.6019/CHEMBL1201861
Homo sapiens Casein kinase I IC50 17000.0 nM 10.1016/j.bmcl.2004.01.050
Homo sapiens Casein kinase I alpha IC50 4000.0 nM 10.1016/j.ejmech.2012.08.033
Homo sapiens Casein kinase I alpha IC50 49000.0 nM 10.1021/acs.jmedchem.8b01541
Homo sapiens Casein kinase I alpha Inhibition 1.0 % 10.1021/jm200064p
Homo sapiens Casein kinase I alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I delta Activity 76.0 % 10.1042/bj20070797
Homo sapiens Casein kinase I delta Delta TM 2.664 C None
Homo sapiens Casein kinase I delta Delta TM 3.05 C None
Homo sapiens Casein kinase I delta IC50 10000.0 nM 10.1021/acs.jmedchem.8b01541
Homo sapiens Casein kinase I delta Kd 260.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I epsilon Delta TM 3.4 C None
Homo sapiens Casein kinase I epsilon Kd 160.0 nM 10.1038/nbt1068
Homo sapiens Casein kinase I epsilon Kd 320.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I epsilon Kd 12409.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 1 Kd 3300.0 nM 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I gamma 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 1 Thermal melting change 1.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase I gamma 2 Kd 1400.0 nM 10.1038/nbt1068
Homo sapiens Casein kinase I gamma 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I gamma 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I gamma 2 Thermal melting change 1.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Casein kinase II Activity 92.0 % 10.1042/bj20070797
Homo sapiens Casein kinase II Inhibition 10.0 % 10.1021/jm200064p
Homo sapiens Casein kinase II alpha Delta TM 0.45 C None
Homo sapiens Casein kinase II alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase II alpha (prime) Delta TM 0.19 C None
Homo sapiens Casein kinase II alpha (prime) Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase II alpha (prime) Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I isoform alpha/delta EC 0.96 uM 10.1021/acs.jmedchem.8b01541
Homo sapiens Casein kinase I isoform alpha/delta EC 9.0 uM 10.1021/acs.jmedchem.8b01541
Homo sapiens Casein kinase I isoform alpha-like Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I isoform gamma-3 Kd 2900.0 nM 10.1038/nbt1358
Homo sapiens Casein kinase I isoform gamma-3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Casein kinase I isoform gamma-3 Thermal melting change 0.9 degrees C 10.1073/pnas.0708800104
Homo sapiens CCRF-CEM GI50 100000.0 nM 10.1021/jm801340z
Homo sapiens CCRF-CEM GI50 100000.0 nM None
Homo sapiens CCRF-CEM IC50 16300.0 nM 10.1016/j.ejmech.2012.06.036
Homo sapiens CCRF-CEM IC50 18200.0 nM 10.1016/s0960-894x(02)00693-5
Homo sapiens CCRF-CEM IC50 106625.21 nM 10.6019/CHEMBL1201861
Homo sapiens CCRF-CEM LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens CCRF-CEM TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens CDK2/Cyclin A2 IC50 0.7 nM 10.1021/acs.jmedchem.1c02064
Homo sapiens CDK2/Cyclin A2 IC50 43.2 nM 10.1016/j.ejmech.2021.113389
Homo sapiens CDK2/Cyclin A2 IC50 72.0 nM 10.1016/j.ejmech.2018.08.100
Homo sapiens CDK2/Cyclin A2 IC50 110.0 nM 10.1016/j.ejmech.2020.112322
Homo sapiens CDK2/Cyclin A2 IC50 193.0 nM 10.1016/j.bmcl.2019.06.059
Homo sapiens CDK2/Cyclin A2 IC50 3490.0 nM 10.1021/acs.jmedchem.7b00324
Homo sapiens CDK2/Cyclin A2 Inhibition 81.32 % 10.1016/j.ejmech.2020.112322
Homo sapiens CDK2/Cyclin A2 Inhibition nan % 10.1016/j.bmcl.2019.06.059
Homo sapiens CDK3/cyclin E Inhibition 20.0 % 10.1016/j.bmc.2011.02.052
Homo sapiens CDK6/cyclin D1 IC50 23500.0 nM 10.1021/jm100732t
Homo sapiens CDK6/cyclin D3 IC50 10000.0 nM 10.1021/acs.jmedchem.7b00324
Homo sapiens CDK7/Cyclin H/MNAT1 IC50 2200.0 nM 10.1021/acs.jmedchem.8b01541
Homo sapiens CDK8/Cyclin C IC50 100.0 nM 10.1021/acs.jmedchem.1c02064
Homo sapiens CDK9/cyclin T1 Delta Tm 1.57 degrees C 10.1021/jm301495v
Homo sapiens CDK9/cyclin T1 IC50 0.6 nM 10.1021/acs.jmedchem.1c02064
Homo sapiens CDK9/cyclin T1 IC50 220.0 nM 10.1016/j.ejmech.2018.08.100
Homo sapiens CDK9/cyclin T1 IC50 230.0 nM 10.1016/j.ejmech.2012.08.033
Homo sapiens CDK9/cyclin T1 IC50 230.0 nM 10.1021/jm801340z
Homo sapiens CDK9/cyclin T1 IC50 800.0 nM 10.1021/jm301475f
Homo sapiens CDK9/cyclin T1 IC50 950.0 nM 10.1021/jm100732t
Homo sapiens CDK9/cyclin T1 IC50 1770.0 nM 10.1021/jm200064p
Homo sapiens CDK9/cyclin T1 IC50 1800.0 nM 10.1016/j.ejmech.2019.112019
Homo sapiens CDK9/cyclin T1 IC50 2694.0 nM 10.1016/j.ejmech.2012.06.036
Homo sapiens CDK9/cyclin T1 Inhibition 19.0 % 10.1016/j.bmc.2011.02.052
Homo sapiens CDK9/cyclin T1 Inhibition 87.0 % 10.1021/jm200064p
Homo sapiens CDK9/cyclin T1 Ki 790.0 nM 10.1021/jm301495v
Homo sapiens Cell division cycle 2-like protein kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cell division protein kinase 8 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cellular tumor antigen p53 Activity nan None 10.1021/jm200064p
Homo sapiens CESS IC50 20854.94 nM 10.6019/CHEMBL1201861
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens cGMP-dependent protein kinase 1 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens cGMP-dependent protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens CGTH-W-1 IC50 44969.75 nM 10.6019/CHEMBL1201861
Homo sapiens CH1 GI50 3250.0 nM 10.1016/j.bmc.2011.08.051
Homo sapiens CH1 GI50 5400.0 nM 10.1016/j.bmc.2011.08.051
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Chaperone activity of bc1 complex-like, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Choline-phosphate cytidylyltransferase A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens CHP-126 IC50 1177183.5 nM 10.6019/CHEMBL1201861
Homo sapiens Chromodomain-helicase-DNA-binding protein 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Citron Rho-interacting kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Citron Rho-interacting kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 1 Activity 89.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 1 Delta TM -1.18 C None
Homo sapiens c-Jun N-terminal kinase 1 IC50 170000.0 nM 10.1021/acs.jmedchem.8b01541
Homo sapiens c-Jun N-terminal kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 1 Kd nan None 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 2 Activity 88.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 2 Delta TM -0.46 C None
Homo sapiens c-Jun N-terminal kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens c-Jun N-terminal kinase 3 Activity 87.0 % 10.1042/bj20070797
Homo sapiens c-Jun N-terminal kinase 3 Delta TM -3.31 C None
Homo sapiens c-Jun N-terminal kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens c-Jun N-terminal kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens c-Jun N-terminal kinase 3 Kd nan None 10.1038/nbt1068
Homo sapiens CMK IC50 207544.75 nM 10.6019/CHEMBL1201861
Homo sapiens COLO 205 GI50 11641.26 nM None
Homo sapiens COLO 205 GI50 12589.25 nM 10.1021/jm801340z
Homo sapiens COLO 205 GI50 12600.0 nM 10.1021/jm801340z
Homo sapiens COLO 205 GI50 24900.0 nM 10.1021/jm100732t
Homo sapiens COLO 205 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens COLO 205 TGI 31600.0 nM 10.1021/jm801340z
Homo sapiens COLO 205 TGI 31622.78 nM 10.1021/jm801340z
Homo sapiens COLO-320-HSR IC50 18768.84 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-668 IC50 81901.8 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-684 IC50 37011.99 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-800 IC50 3345314.54 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-824 IC50 719245.68 nM 10.6019/CHEMBL1201861
Homo sapiens COLO-829 IC50 742149.72 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L279 IC50 12290.71 nM 10.6019/CHEMBL1201861
Homo sapiens COR-L88 IC50 2516947.16 nM 10.6019/CHEMBL1201861
Homo sapiens CP66-MEL IC50 652087.01 nM 10.6019/CHEMBL1201861
Homo sapiens CPC-N IC50 307404.66 nM 10.6019/CHEMBL1201861
Homo sapiens CTB-1 IC50 263426.13 nM 10.6019/CHEMBL1201861
Homo sapiens CTV-1 IC50 237377.57 nM 10.6019/CHEMBL1201861
Homo sapiens CW-2 IC50 99493.17 nM 10.6019/CHEMBL1201861
Homo sapiens Cyclin A2 Inhibition nan % 10.1021/jm100732t
Homo sapiens Cyclin-dependent kinase INH 24.5 uM 10.1016/j.ejmech.2012.06.036
Homo sapiens Cyclin-dependent kinase 1 IC50 81.7 nM 10.1039/d2md00192f
Homo sapiens Cyclin-dependent kinase 1 IC50 200.0 nM 10.1021/jm960666x
Homo sapiens Cyclin-dependent kinase 1 IC50 200.0 nM 10.1021/np000546z
Homo sapiens Cyclin-dependent kinase 1 IC50 330.0 nM 10.1016/j.ejmech.2019.03.064
Homo sapiens Cyclin-dependent kinase 1 IC50 450.0 nM 10.1016/s0960-894x(03)00632-2
Homo sapiens Cyclin-dependent kinase 1 IC50 450.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Cyclin-dependent kinase 1 IC50 450.0 nM 10.1021/jm000965t
Homo sapiens Cyclin-dependent kinase 1 IC50 450.0 nM 10.1208/aapsj080125
Homo sapiens Cyclin-dependent kinase 1 IC50 1500.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 1 IC50 2421.0 nM 10.1021/jm4006884
Homo sapiens Cyclin-dependent kinase 1 IC50 700000.0 nM 10.1021/jm011002c
Homo sapiens Cyclin-dependent kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 12 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 13 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 450.0 nM 10.1016/j.bmcl.2004.01.050
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 450.0 nM 10.1016/s0960-894x(02)00693-5
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 650.0 nM 10.1021/jm011002c
Homo sapiens Cyclin-dependent kinase 1/cyclin B IC50 650.0 nM 10.1021/jm9911130
Homo sapiens Cyclin-dependent kinase 1/cyclin B ID50 0.65 uM 10.1021/jm991182e
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 81.7 nM 10.1016/j.bmc.2020.115633
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 350.0 nM 10.1016/j.bmcl.2012.10.141
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 450.0 nM 10.1016/j.ejmech.2007.09.020
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 450.0 nM 10.1016/s0960-894x(98)00097-3
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 2100.0 nM 10.1021/jm100732t
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 2400.0 nM 10.1016/j.ejmech.2013.01.021
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 2690.0 nM 10.1016/j.ejmech.2021.113281
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 2690.0 nM 10.1021/jm401073p
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 2900.0 nM 10.1016/j.bmcl.2016.05.004
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 7890.0 nM 10.1021/acs.jmedchem.7b00324
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 17000.0 nM 10.1016/j.bmc.2011.08.051
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Inhibition 10.0 % 10.1016/j.bmc.2011.02.052
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Inhibition 70.0 % 10.1021/jm200064p
Homo sapiens Cyclin-dependent kinase 2 Delta TM 2.87 C None
Homo sapiens Cyclin-dependent kinase 2 Delta TM 4.07 C None
Homo sapiens Cyclin-dependent kinase 2 IC50 0.7 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens Cyclin-dependent kinase 2 IC50 90.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 2 IC50 100.0 nM 10.1021/acs.jmedchem.0c00744
Homo sapiens Cyclin-dependent kinase 2 IC50 100.0 nM 10.1021/acs.jmedchem.0c01467
Homo sapiens Cyclin-dependent kinase 2 IC50 100.0 nM 10.1021/jm8002813
Homo sapiens Cyclin-dependent kinase 2 IC50 220.0 nM 10.1016/j.ejmech.2019.03.064
Homo sapiens Cyclin-dependent kinase 2 IC50 220.0 nM 10.1021/jm801340z
Homo sapiens Cyclin-dependent kinase 2 IC50 370.0 nM 10.1021/jm800382h
Homo sapiens Cyclin-dependent kinase 2 IC50 400.0 nM 10.1021/acs.jmedchem.8b01541
Homo sapiens Cyclin-dependent kinase 2 IC50 430.0 nM 10.1016/j.ejmech.2020.112571
Homo sapiens Cyclin-dependent kinase 2 IC50 500.0 nM 10.1016/j.ejmech.2013.07.003
Homo sapiens Cyclin-dependent kinase 2 IC50 600.0 nM 10.1016/s0960-894x(00)00014-7
Homo sapiens Cyclin-dependent kinase 2 IC50 700.0 nM 10.1016/j.ejmech.2008.01.010
Homo sapiens Cyclin-dependent kinase 2 IC50 700.0 nM 10.1016/j.ejmech.2017.08.071
Homo sapiens Cyclin-dependent kinase 2 IC50 700.0 nM 10.1016/j.ejmech.2020.112571
Homo sapiens Cyclin-dependent kinase 2 IC50 700.0 nM 10.1021/acs.jmedchem.1c02190
Homo sapiens Cyclin-dependent kinase 2 IC50 700.0 nM 10.1208/aapsj080125
Homo sapiens Cyclin-dependent kinase 2 Inhibition nan % 10.1021/jm100732t
Homo sapiens Cyclin-dependent kinase 2 Kd 2900.0 nM 10.1038/nbt1068
Homo sapiens Cyclin-dependent kinase 2 Kd 3400.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 2 Selectivity 0.0313 None 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 2 Thermal melting change 1.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 2/cyclin A Activity 4.0 % 10.1042/bj20070797
Homo sapiens Cyclin-dependent kinase 2/cyclin A Delta Tm 2.56 degrees C 10.1021/jm301495v
Homo sapiens Cyclin-dependent kinase 2/cyclin A EC50 151.0 nM 10.1021/ml3002083
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 100.0 nM 10.1021/jm301475f
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 140.0 nM 10.1042/bj20070797
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 210.0 nM 10.1016/j.ejmech.2012.08.033
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 500.0 nM 10.1016/j.ejmech.2011.09.041
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 700.0 nM 10.1007/s00044-009-9233-5
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 700.0 nM 10.1016/j.bmc.2010.11.022
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 700.0 nM 10.1016/j.bmcl.2012.10.141
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 700.0 nM 10.1021/jm011002c
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 4600.0 nM 10.1016/j.bmcl.2009.10.011
Homo sapiens Cyclin-dependent kinase 2/cyclin A IC50 4600.0 nM 10.1016/j.bmcl.2009.10.025
Homo sapiens Cyclin-dependent kinase 2/cyclin A Inhibition 41.0 % 10.1016/j.bmc.2011.02.052
Homo sapiens Cyclin-dependent kinase 2/cyclin A Inhibition 94.0 % 10.1021/jm200064p
Homo sapiens Cyclin-dependent kinase 2/cyclin A Ki 250.0 nM 10.1021/jm301495v
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 100.0 nM 10.1158/0008-5472.can-05-0233
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 520.0 nM 10.1016/j.bmcl.2009.10.011
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 520.0 nM 10.1016/j.bmcl.2009.10.025
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 650.0 nM 10.1021/jm001043t
Homo sapiens Cyclin-dependent kinase 2/cyclin E IC50 700.0 nM 10.1021/jm011002c
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 18.0 nM 10.1021/acs.jmedchem.1c02184
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 100.0 nM 10.1016/j.bmc.2015.02.026
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 100.0 nM 10.1016/j.bmcl.2016.05.004
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 100.0 nM 10.1016/j.ejmech.2014.03.054
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 100.0 nM 10.1016/j.ejmech.2019.112019
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 100.0 nM 10.1016/j.ejmech.2021.113281
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 100.0 nM 10.1021/acs.jmedchem.9b01985
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 100.0 nM 10.1021/jm100732t
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 100.0 nM 10.1021/jm401073p
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 158.0 nM 10.1016/j.ejmech.2016.01.011
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 170.0 nM 10.1016/j.ejmech.2013.01.021
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 170.0 nM 10.1021/jm4006884
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 180.0 nM 10.1016/j.ejmech.2012.06.036
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 200.0 nM 10.1016/j.ejmech.2015.12.023
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 220.0 nM 10.1016/j.bmc.2011.08.051
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 220.0 nM 10.1016/j.bmcl.2019.126637
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 220.0 nM 10.1021/jm200064p
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 620.0 nM 10.1021/acs.jmedchem.7b00324
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 700.0 nM 10.1007/s00044-009-9233-5
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 707.95 nM 10.1016/j.ejmech.2015.12.023
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 Inhibition 57.0 % 10.1016/j.bmc.2011.02.052
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 Inhibition 95.0 % 10.1021/jm200064p
Homo sapiens Cyclin-dependent kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 4 IC50 10000.0 nM 10.1016/j.ejmech.2019.03.064
Homo sapiens Cyclin-dependent kinase 4 IC50 16400.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 4 IC50 100000.0 nM 10.1016/s0960-894x(00)00014-7
Homo sapiens Cyclin-dependent kinase 4 IC50 100000.0 nM 10.1208/aapsj080125
Homo sapiens Cyclin-dependent kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 13500.0 nM 10.1021/jm100732t
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 14210.0 nM 10.1016/j.ejmech.2021.113281
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 14210.0 nM 10.1021/jm401073p
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 27000.0 nM 10.1016/j.bmc.2011.08.051
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 100000.0 nM 10.1021/jm011002c
Homo sapiens Cyclin-dependent kinase 5 IC50 0.2 nM 10.1021/acs.jmedchem.1c00302
Homo sapiens Cyclin-dependent kinase 5 IC50 160.0 nM 10.1016/j.bmc.2010.11.022
Homo sapiens Cyclin-dependent kinase 5 IC50 160.0 nM 10.1016/j.ejmech.2017.08.071
Homo sapiens Cyclin-dependent kinase 5 IC50 160.0 nM 10.1016/j.ejmech.2020.112571
Homo sapiens Cyclin-dependent kinase 5 IC50 160.0 nM 10.1208/aapsj080125
Homo sapiens Cyclin-dependent kinase 5 IC50 200.0 nM 10.1016/j.ejmech.2019.01.003
Homo sapiens Cyclin-dependent kinase 5 IC50 200.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 5 IC50 270.0 nM 10.1016/j.ejmech.2019.03.064
Homo sapiens Cyclin-dependent kinase 5 IC50 1069.0 nM 10.1016/j.ejmech.2016.01.011
Homo sapiens Cyclin-dependent kinase 5 IC50 nan nM 10.1021/jm000965t
Homo sapiens Cyclin-dependent kinase 5 Kd 1900.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 5 Kd 2000.0 nM 10.1038/nbt1068
Homo sapiens Cyclin-dependent kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 160.0 nM 10.1016/j.bmc.2010.11.022
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 160.0 nM 10.1016/j.bmcl.2004.01.050
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 160.0 nM 10.1016/j.ejmech.2007.09.020
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 200.0 nM 10.1016/j.bmcl.2012.10.141
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 200.0 nM 10.1016/j.ejmech.2012.09.001
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 200.0 nM 10.1016/j.ejmech.2018.08.100
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 200.0 nM 10.1021/jm049323m
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 270.0 nM 10.1016/j.bmcl.2011.01.140
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 270.0 nM 10.1021/acsmedchemlett.9b00029
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 270.0 nM 10.1021/jm801340z
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 280.0 nM 10.1016/j.ejmech.2011.02.059
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 280.0 nM 10.1016/j.ejmech.2012.08.033
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 280.0 nM 10.1016/j.ejmech.2014.06.063
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 800.0 nM 10.1016/s0960-894x(02)00094-x
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 930.0 nM 10.1016/j.bmcl.2013.07.020
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 940.0 nM 10.1021/jm200064p
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 1080.0 nM 10.1016/j.ejmech.2012.06.036
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Inhibition 40.0 % 10.1016/j.bmc.2011.02.052
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Inhibition 41.0 % 10.1016/j.bmc.2011.02.052
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Inhibition 85.0 % 10.1021/jm200064p
Homo sapiens Cyclin-dependent kinase 6 IC50 24500.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 6 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase 7 IC50 480.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 7 IC50 500.0 nM 10.1021/acs.jmedchem.0c00744
Homo sapiens Cyclin-dependent kinase 7 IC50 510.0 nM 10.1021/acs.jmedchem.9b01985
Homo sapiens Cyclin-dependent kinase 7 IC50 800.0 nM 10.1016/j.ejmech.2019.03.064
Homo sapiens Cyclin-dependent kinase 7 Kd 1800.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase 7 Kd 3705.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 0.46 nM 10.1021/acs.jmedchem.1c02064
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 360.0 nM 10.1158/0008-5472.can-05-0233
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 480.0 nM 10.1021/jm200064p
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 490.0 nM 10.1016/j.ejmech.2021.113281
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 490.0 nM 10.1021/jm401073p
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 500.0 nM 10.1021/jm301475f
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 520.0 nM 10.1016/j.bmc.2011.08.051
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 520.0 nM 10.1016/j.bmcl.2019.126637
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 540.0 nM 10.1021/jm100732t
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 793.0 nM 10.1016/j.ejmech.2012.06.036
Homo sapiens Cyclin-dependent kinase 7/ cyclin H IC50 800.0 nM 10.1021/jm801340z
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Inhibition 26.0 % 10.1016/j.bmc.2011.02.052
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Inhibition 87.0 % 10.1021/jm200064p
Homo sapiens Cyclin-dependent kinase 9 IC50 230.0 nM 10.1016/j.ejmech.2019.03.064
Homo sapiens Cyclin-dependent kinase 9 IC50 230.0 nM 10.1021/acs.jmedchem.0c00744
Homo sapiens Cyclin-dependent kinase 9 IC50 1050.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens Cyclin-dependent kinase 9 Kd 4860.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-dependent kinase 9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Cyclin-dependent kinase-like 1 Delta TM 0.44 C None
Homo sapiens Cyclin-dependent kinase-like 1 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Cyclin-dependent kinase-like 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cyclin-T1/Cyclin-dependent-like kinase 5 IC50 160.0 nM 10.1021/jm100732t
Homo sapiens Cysteine--tRNA ligase, cytoplasmic Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Cytochrome c1, heme protein, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens D-247MG IC50 12351.58 nM 10.6019/CHEMBL1201861
Homo sapiens D-263MG IC50 68047.3 nM 10.6019/CHEMBL1201861
Homo sapiens D283 Med IC50 772001.89 nM 10.6019/CHEMBL1201861
Homo sapiens D-336MG IC50 543555.6 nM 10.6019/CHEMBL1201861
Homo sapiens D-392MG IC50 292958.51 nM 10.6019/CHEMBL1201861
Homo sapiens D-502MG IC50 247038.2 nM 10.6019/CHEMBL1201861
Homo sapiens D-542MG IC50 67095.43 nM 10.6019/CHEMBL1201861
Homo sapiens Daudi IC50 3151547.87 nM 10.6019/CHEMBL1201861
Homo sapiens DB IC50 69546.74 nM 10.6019/CHEMBL1201861
Homo sapiens dCTP pyrophosphatase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Death-associated protein kinase 1 Delta TM -0.59 C None
Homo sapiens Death-associated protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Death-associated protein kinase 3 Delta TM 0.62 C None
Homo sapiens Death-associated protein kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Death-associated protein kinase 3 Kd nan None 10.1038/nbt1068
Homo sapiens Death-associated protein kinase 3 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens DEL IC50 91329.79 nM 10.6019/CHEMBL1201861
Homo sapiens Delta(24)-sterol reductase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Deoxycytidine kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DG-75 IC50 42654.59 nM 10.6019/CHEMBL1201861
Homo sapiens Discoidin domain-containing receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Discoidin domain-containing receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DJM-1 IC50 268865.97 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-114 IC50 167435.8 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-153 IC50 65496.58 nM 10.6019/CHEMBL1201861
Homo sapiens DMS-79 IC50 89108.79 nM 10.6019/CHEMBL1201861
Homo sapiens DnaJ homolog subfamily A member 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA replication licensing factor MCM4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA topoisomerase II alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DNA topoisomerase II beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens DOHH-2 IC50 174048.85 nM 10.6019/CHEMBL1201861
Homo sapiens DSH1 IC50 253600.45 nM 10.6019/CHEMBL1201861
Homo sapiens DU-145 GI50 15800.0 nM 10.1021/jm801340z
Homo sapiens DU-145 GI50 16865.53 nM None
Homo sapiens DU-145 GI50 19952.62 nM 10.1021/jm801340z
Homo sapiens DU-145 IC50 1900.0 nM 10.1016/j.bmcl.2013.03.129
Homo sapiens DU-145 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens DU-145 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens DU-4475 IC50 48493.71 nM 10.6019/CHEMBL1201861
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Activity 81.0 % 10.1042/bj20070797
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Inhibition 38.0 % 10.1021/jm200064p
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Delta TM 0.56 C None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Delta TM 0.4 C None
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Delta TM -1.29 C None
Homo sapiens Dual specificity protein kinase CLK2 Kd 470.0 nM 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK2 Kd 700.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity protein kinase CLK2 Thermal melting change 2.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity protein kinase CLK3 Delta TM 0.71 C None
Homo sapiens Dual specificity protein kinase CLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase CLK3 Kd nan None 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK3 Thermal melting change 0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Dual specificity protein kinase CLK4 Kd 4500.0 nM 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase CLK4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase TTK Delta TM 1.18 C None
Homo sapiens Dual specificity protein kinase TTK Kd 1600.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity protein kinase TTK Kd 2100.0 nM 10.1038/nbt1068
Homo sapiens Dual specificity protein kinase TTK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Dual specificity testis-specific protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity testis-specific protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 87.0 % 10.1016/j.bmcl.2012.10.141
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 87.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Activity 88.0 % 10.1016/j.bmcl.2012.10.141
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Delta TM 3.38 C None
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 1200.0 nM 10.1016/j.ejmech.2018.08.100
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 3000.0 nM 10.1016/j.ejmech.2012.08.033
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 3100.0 nM 10.1021/acs.jmedchem.8b00185
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 3100.0 nM 10.1021/jm401049v
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 5000.0 nM 10.1016/j.bmcl.2009.02.062
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 18000.0 nM 10.1021/np070341r
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Inhibition 63.0 % 10.1016/j.bmcl.2009.02.062
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kd 40291.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B IC50 1200.0 nM 10.1016/j.ejmech.2018.08.100
Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kd 1100.0 nM 10.1038/nbt1358
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Activity 90.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Delta TM 0.88 C None
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 IC50 1700.0 nM 10.1016/j.ejmech.2018.08.100
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 Activity 97.0 % 10.1042/bj20070797
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 3 IC50 10000.0 nM 10.1016/j.ejmech.2018.08.100
Homo sapiens Dual specificty protein kinase CLK1 Delta TM 4.13 C None
Homo sapiens Dual specificty protein kinase CLK1 Inhibition nan % 10.1021/jm200274d
Homo sapiens Dual specificty protein kinase CLK1 Kd 1200.0 nM 10.1038/nbt1358
Homo sapiens Dual specificty protein kinase CLK1 Kd 2100.0 nM 10.1038/nbt1068
Homo sapiens Dual specificty protein kinase CLK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Dual specificty protein kinase CLK1 Thermal melting change 2.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Dynamin-like 120 kDa protein, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens EB2 IC50 1284013.5 nM 10.6019/CHEMBL1201861
Homo sapiens EB-3 IC50 23183.11 nM 10.6019/CHEMBL1201861
Homo sapiens ECC12 IC50 288995.18 nM 10.6019/CHEMBL1201861
Homo sapiens ECC4 IC50 381103.5 nM 10.6019/CHEMBL1201861
Homo sapiens EC-GI-10 IC50 3488600.74 nM 10.6019/CHEMBL1201861
Homo sapiens EHEB IC50 79182.87 nM 10.6019/CHEMBL1201861
Homo sapiens EKVX GI50 19098.53 nM None
Homo sapiens EKVX GI50 19900.0 nM 10.1021/jm801340z
Homo sapiens EKVX GI50 19952.62 nM 10.1021/jm801340z
Homo sapiens EKVX IC50 529923.15 nM 10.6019/CHEMBL1201861
Homo sapiens EKVX LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens EKVX TGI 50100.0 nM 10.1021/jm801340z
Homo sapiens EKVX TGI 50118.72 nM 10.1021/jm801340z
Homo sapiens Electron transfer flavoprotein subunit beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Elongation factor Tu, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens EM-2 IC50 923655.35 nM 10.6019/CHEMBL1201861
Homo sapiens EOL1 IC50 3603147.33 nM 10.6019/CHEMBL1201861
Homo sapiens Ephrin type-A receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 2 Delta TM 0.59 C None
Homo sapiens Ephrin type-A receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 4 Delta TM -0.2 C None
Homo sapiens Ephrin type-A receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 4 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 5 Delta TM 0.21 C None
Homo sapiens Ephrin type-A receptor 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 5 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 6 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 7 Delta TM -3.85 C None
Homo sapiens Ephrin type-A receptor 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-A receptor 7 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-A receptor 8 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-A receptor 8 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 1 Delta TM 0.29 C None
Homo sapiens Ephrin type-B receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 1 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 3 Delta TM 0.46 C None
Homo sapiens Ephrin type-B receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ephrin type-B receptor 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ephrin type-B receptor 4 Kd nan None 10.1038/nbt1068
Homo sapiens Ephrin type-B receptor 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Epidermal growth factor receptor erbB1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Epidermal growth factor receptor erbB1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Epidermal growth factor receptor erbB1 Kd nan None 10.1038/nbt1068
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Epithelial discoidin domain-containing receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ES1 IC50 271582.51 nM 10.6019/CHEMBL1201861
Homo sapiens ES3 IC50 29958.23 nM 10.6019/CHEMBL1201861
Homo sapiens ES4 IC50 293211.15 nM 10.6019/CHEMBL1201861
Homo sapiens ES5 IC50 4414875.88 nM 10.6019/CHEMBL1201861
Homo sapiens ES6 IC50 86404.61 nM 10.6019/CHEMBL1201861
Homo sapiens ES7 IC50 535327.66 nM 10.6019/CHEMBL1201861
Homo sapiens ES8 IC50 21060.03 nM 10.6019/CHEMBL1201861
Homo sapiens ETK-1 IC50 185096.81 nM 10.6019/CHEMBL1201861
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Eukaryotic translation initiation factor 2-alpha kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens EVSA-T IC50 152104.99 nM 10.6019/CHEMBL1201861
Homo sapiens EW-1 IC50 65621.74 nM 10.6019/CHEMBL1201861
Homo sapiens EW-11 IC50 1512148.85 nM 10.6019/CHEMBL1201861
Homo sapiens EW-12 IC50 3183581.18 nM 10.6019/CHEMBL1201861
Homo sapiens EW-13 IC50 541947.97 nM 10.6019/CHEMBL1201861
Homo sapiens EW-16 IC50 74334.93 nM 10.6019/CHEMBL1201861
Homo sapiens EW-18 IC50 3731800.11 nM 10.6019/CHEMBL1201861
Homo sapiens EW-24 IC50 1192057.4 nM 10.6019/CHEMBL1201861
Homo sapiens EW-3 IC50 999510.84 nM 10.6019/CHEMBL1201861
Homo sapiens Exosome RNA helicase MTR4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ferrochelatase, mitochondrial Delta TM -1.37 C None
Homo sapiens Ferrochelatase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Fibroblast Activity 40.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens Fibroblast Growth Rate 0.0 None 10.6019/CHEMBL4689842
Homo sapiens Fibroblast IC50 6000.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens Fibroblast IC50 7000.0 nM 10.1021/acs.jnatprod.5b01073
Homo sapiens Fibroblast IC50 12000.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens Fibroblast IC50 15000.0 nM 10.1016/j.bmcl.2021.128390
Homo sapiens Fibroblast growth factor receptor 1 Delta TM 0.36 C None
Homo sapiens Fibroblast growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Fibroblast growth factor receptor 1 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 2 Delta TM -0.08 C None
Homo sapiens Fibroblast growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 3 Delta TM 0.05923 C None
Homo sapiens Fibroblast growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Fibroblast growth factor receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Fibroblast growth factor receptor 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Flotillin-1 Delta TM 0.77 C None
Homo sapiens Focal adhesion kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Focal adhesion kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Focal adhesion kinase 1 Kd nan None 10.1038/nbt1068
Homo sapiens G1/S-specific cyclin D1 Inhibition nan % 10.1021/jm100732t
Homo sapiens G2/mitotic-specific cyclin B1 Inhibition nan % 10.1021/jm100732t
Homo sapiens G-361 FC nan None 10.1016/j.ejmech.2015.12.023
Homo sapiens G-361 IC50 22400.0 nM 10.1016/j.ejmech.2012.06.036
Homo sapiens G-361 IC50 22400.0 nM 10.1021/jm4006884
Homo sapiens G-361 IC50 34000.0 nM 10.1016/s0960-894x(02)00693-5
Homo sapiens GB-1 IC50 113128.24 nM 10.6019/CHEMBL1201861
Homo sapiens GCIY IC50 12861.34 nM 10.6019/CHEMBL1201861
Homo sapiens GDM-1 IC50 117740.38 nM 10.6019/CHEMBL1201861
Homo sapiens Geminin Potency 15848.9 nM None
Homo sapiens Geminin Potency 20596.2 nM None
Homo sapiens General transcription and DNA repair factor IIH helicase subunit XPD Kd 12022.0 nM 10.1126/science.aan4368
Homo sapiens GI-1 IC50 29011.29 nM 10.6019/CHEMBL1201861
Homo sapiens GI-ME-N IC50 42667.14 nM 10.6019/CHEMBL1201861
Homo sapiens Glycine--tRNA ligase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 IC50 60000.0 nM 10.1016/j.ejmech.2012.08.033
Homo sapiens Glycogen synthase kinase-3 IC50 130000.0 nM 10.1016/j.ejmech.2007.09.020
Homo sapiens Glycogen synthase kinase-3 alpha Inhibition 13.0 % 10.1021/jm200064p
Homo sapiens Glycogen synthase kinase-3 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Glycogen synthase kinase-3 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 beta Activity 76.0 % 10.1042/bj20070797
Homo sapiens Glycogen synthase kinase-3 beta Delta TM 1.64 C None
Homo sapiens Glycogen synthase kinase-3 beta Delta TM 2.248 C None
Homo sapiens Glycogen synthase kinase-3 beta IC50 130000.0 nM 10.1016/j.bmcl.2004.01.050
Homo sapiens Glycogen synthase kinase-3 beta IC50 nan None 10.1021/acs.jmedchem.7b00324
Homo sapiens Glycogen synthase kinase-3 beta Inhibition 25.0 % 10.1021/jm200064p
Homo sapiens Glycogen synthase kinase-3 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Glycogen synthase kinase-3 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Glycogen synthase kinase-3 beta Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens GOTO IC50 32912.91 nM 10.6019/CHEMBL1201861
Homo sapiens G-protein coupled receptor kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens G protein-coupled receptor kinase 5 Delta TM -0.05 C None
Homo sapiens GR-ST IC50 557476.86 nM 10.6019/CHEMBL1201861
Homo sapiens GT3TKB IC50 115394.77 nM 10.6019/CHEMBL1201861
Homo sapiens GTP-binding nuclear protein Ran Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens HaCaT Activity 3.0 % 10.1016/j.bmc.2017.01.049
Homo sapiens HaCaT Activity 26.0 % 10.1016/j.bmc.2017.01.049
Homo sapiens HaCaT Activity 80.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens HaCaT Activity nan None 10.1016/j.bmc.2017.01.049
Homo sapiens HaCaT Activity_index 0.0 None 10.1016/j.bmc.2017.01.049
Homo sapiens HaCaT Activity_index 1.7 None 10.1016/j.bmc.2017.01.049
Homo sapiens HaCaT IC50 12000.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens HaCaT IC50 16700.0 nM 10.1016/j.bmc.2017.01.049
Homo sapiens HAL-01 IC50 79665.77 nM 10.6019/CHEMBL1201861
Homo sapiens HC-1 IC50 64145.7 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1187 IC50 312627.38 nM 10.6019/CHEMBL1201861
Homo sapiens HCC1599 IC50 14597.5 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2157 IC50 194528.37 nM 10.6019/CHEMBL1201861
Homo sapiens HCC2218 IC50 1780897.98 nM 10.6019/CHEMBL1201861
Homo sapiens HCC 2998 GI50 31600.0 nM 10.1021/jm801340z
Homo sapiens HCC 2998 GI50 31622.78 nM 10.1021/jm801340z
Homo sapiens HCC 2998 GI50 32210.69 nM None
Homo sapiens HCC 2998 IC50 165626.13 nM 10.6019/CHEMBL1201861
Homo sapiens HCC 2998 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens HCC 2998 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens HCE-T IC50 530972.91 nM 10.6019/CHEMBL1201861
Homo sapiens HCT-116 Activity 0.24 % 10.1016/j.ejmech.2020.112322
Homo sapiens HCT-116 Activity 0.6 % 10.1016/j.bmc.2017.01.049
Homo sapiens HCT-116 Activity 1.2 % 10.1016/j.bmc.2017.01.049
Homo sapiens HCT-116 Activity 4.24 % 10.1016/j.ejmech.2020.112322
Homo sapiens HCT-116 Activity 11.6 % 10.1016/j.ejmech.2020.112322
Homo sapiens HCT-116 Activity 17.0 % 10.1016/j.bmc.2017.01.049
Homo sapiens HCT-116 Activity 25.0 % 10.1016/j.bmc.2017.01.049
Homo sapiens HCT-116 Activity 83.9 % 10.1016/j.ejmech.2020.112322
Homo sapiens HCT-116 Activity 100.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens HCT-116 Activity nan None 10.1016/j.bmc.2017.01.049
Homo sapiens HCT-116 Activity_index 0.6 None 10.1016/j.bmc.2017.01.049
Homo sapiens HCT-116 Activity_index 1.2 None 10.1016/j.bmc.2017.01.049
Homo sapiens HCT-116 GI50 5010.0 nM 10.1021/jm801340z
Homo sapiens HCT-116 GI50 5011.87 nM 10.1021/jm801340z
Homo sapiens HCT-116 GI50 5050.0 nM 10.1016/j.bmc.2011.08.051
Homo sapiens HCT-116 GI50 5093.31 nM None
Homo sapiens HCT-116 GI50 15500.0 nM 10.1021/jm100732t
Homo sapiens HCT-116 IC50 2000.0 nM 10.1016/j.ejmech.2015.06.046
Homo sapiens HCT-116 IC50 5000.0 nM 10.1016/j.bmc.2009.07.051
Homo sapiens HCT-116 IC50 6760.0 nM 10.1016/j.ejmech.2020.112322
Homo sapiens HCT-116 IC50 7000.0 nM 10.1016/j.ejmech.2012.09.001
Homo sapiens HCT-116 IC50 8000.0 nM 10.1016/j.bmc.2017.01.049
Homo sapiens HCT-116 IC50 8000.0 nM 10.1016/j.ejmech.2011.08.048
Homo sapiens HCT-116 IC50 9000.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens HCT-116 IC50 9000.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens HCT-116 IC50 9000.0 nM 10.1016/j.bmcl.2021.128390
Homo sapiens HCT-116 IC50 9000.0 nM 10.1021/acs.jnatprod.5b01073
Homo sapiens HCT-116 IC50 14400.0 nM 10.1016/j.ejmech.2012.06.036
Homo sapiens HCT-116 IC50 14400.0 nM 10.1021/jm4006884
Homo sapiens HCT-116 IC50 15540.0 nM 10.1016/j.bmc.2020.115633
Homo sapiens HCT-116 IC50 16380.0 nM 10.1016/j.bmcl.2012.08.117
Homo sapiens HCT-116 Inhibition 23.5 % 10.1016/j.ejmech.2020.112322
Homo sapiens HCT-116 Inhibition 29.1 % 10.1016/j.ejmech.2020.112322
Homo sapiens HCT-116 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens HCT-116 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens HCT-15 GI50 19319.68 nM None
Homo sapiens HCT-15 GI50 19900.0 nM 10.1021/jm801340z
Homo sapiens HCT-15 GI50 19952.62 nM 10.1021/jm801340z
Homo sapiens HCT-15 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens HCT-15 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens HDLM-2 IC50 1593659.14 nM 10.6019/CHEMBL1201861
Homo sapiens HD-MY-Z IC50 16824.65 nM 10.6019/CHEMBL1201861
Homo sapiens HEK293 CC50 20000.0 nM 10.6019/CHEMBL4513161
Homo sapiens HEK293 IC50 46700.0 nM 10.1021/jm800109e
Homo sapiens HEK293 IC50 48900.0 nM 10.1021/jm801340z
Homo sapiens HEK-293T Growth Rate 0.0 None 10.6019/CHEMBL4689842
Homo sapiens HEK-293T Growth Rate 1.0 None 10.6019/CHEMBL4689842
Homo sapiens HEL IC50 52077.03 nM 10.6019/CHEMBL1201861
Homo sapiens HeLa Activity 0.424 % 10.1016/j.ejmech.2020.112322
Homo sapiens HeLa Activity 4.04 % 10.1016/j.ejmech.2020.112322
Homo sapiens HeLa Activity 7.16 % 10.1016/j.ejmech.2020.112322
Homo sapiens HeLa Activity 88.4 % 10.1016/j.ejmech.2020.112322
Homo sapiens HeLa IC50 1810.0 nM 10.1016/j.bmcl.2013.03.129
Homo sapiens HeLa IC50 2200.0 nM 10.1039/d2md00192f
Homo sapiens HeLa IC50 11210.0 nM 10.1016/j.ejmech.2020.112322
Homo sapiens HeLa IC50 28600.0 nM 10.1021/jm4006884
Homo sapiens Heme oxygenase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Hepatocyte growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Hepatocyte growth factor receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens HepG2 GI50 25900.0 nM 10.1021/jm100732t
Homo sapiens HepG2 IC50 8530.0 nM 10.1016/j.ejmech.2020.112322
Homo sapiens HepG2 IC50 15470.0 nM 10.1016/j.bmcl.2012.08.117
Homo sapiens HepG2 IC50 15760.0 nM 10.1016/j.bmcl.2019.06.059
Homo sapiens HepG2 IC50 nan ug.mL-1 10.1016/s0960-894x(00)00014-7
Homo sapiens HepG2 IC50 relative 7800.0 nM 10.6019/EOS300108
Homo sapiens HepG2 Inhibition 12.01 % 10.1016/j.ejmech.2020.112322
Homo sapiens HepG2 Inhibition 22.11 % 10.1016/j.ejmech.2020.112322
Homo sapiens HERG Potency 35481.3 nM None
Homo sapiens HH IC50 24381.87 nM 10.6019/CHEMBL1201861
Homo sapiens Histone deacetylase 1 IC50 nan None 10.1016/j.bmcl.2019.06.059
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1016/j.bmcl.2019.06.059
Homo sapiens Histone deacetylase 1 Inhibition nan % 10.1016/j.ejmech.2020.112322
Homo sapiens Histone deacetylase 6 Inhibition 0.13 % 10.6019/CHEMBL4808148
Homo sapiens Histone deacetylase 6 Inhibition 30.82 % 10.6019/CHEMBL4808148
Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Potency 10000.0 nM None
Homo sapiens HL-60 GI50 21677.04 nM None
Homo sapiens HL-60 IC50 27986.86 nM 10.6019/CHEMBL1201861
Homo sapiens HL-60 IC50 nan ug.mL-1 10.1016/s0960-894x(00)00014-7
Homo sapiens Homeodomain-interacting protein kinase 2 Activity 84.0 % 10.1042/bj20070797
Homo sapiens Homeodomain-interacting protein kinase 2 Delta TM 0.38 C None
Homo sapiens Homeodomain-interacting protein kinase 3 Activity 90.0 % 10.1042/bj20070797
Homo sapiens HOP-62 GI50 24603.68 nM None
Homo sapiens HOP-62 GI50 25100.0 nM 10.1021/jm801340z
Homo sapiens HOP-62 GI50 25118.86 nM 10.1021/jm801340z
Homo sapiens HOP-62 IC50 25442.53 nM 10.6019/CHEMBL1201861
Homo sapiens HOP-62 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens HOP-62 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens HOP-92 GI50 50100.0 nM 10.1021/jm801340z
Homo sapiens HOP-92 GI50 50118.72 nM 10.1021/jm801340z
Homo sapiens HOP-92 GI50 50933.09 nM None
Homo sapiens HOP-92 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens HOP-92 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens HOS IC50 24300.0 nM 10.1016/j.ejmech.2012.06.036
Homo sapiens HOS IC50 24300.0 nM 10.1021/jm4006884
Homo sapiens HOS IC50 32000.0 nM 10.1016/s0960-894x(02)00693-5
Homo sapiens HT IC50 42002.75 nM 10.6019/CHEMBL1201861
Homo sapiens HT-1080 IC50 9620.0 nM 10.1016/j.bmcl.2012.08.117
Homo sapiens HT-1080 IC50 16800.0 nM 10.1021/jm100080z
Homo sapiens HT-144 IC50 63409.27 nM 10.6019/CHEMBL1201861
Homo sapiens HT-29 Activity 0.1 % 10.1021/jm0605740
Homo sapiens HT-29 Activity 1.1 % 10.1021/jm0605740
Homo sapiens HT-29 Activity 34.5 % 10.1021/jm0605740
Homo sapiens HT-29 Activity 44.0 % 10.1021/jm0605740
Homo sapiens HT-29 Activity 48.0 % 10.1021/jm0605740
Homo sapiens HT-29 Activity 50.9 % 10.1021/jm0605740
Homo sapiens HT-29 Activity 55.9 % 10.1021/jm0605740
Homo sapiens HT-29 Activity 64.5 % 10.1021/jm0605740
Homo sapiens HT-29 Activity 19150.0 None 10.1021/jm0605740
Homo sapiens HT-29 Activity 24350.0 None 10.1021/jm0605740
Homo sapiens HT-29 Activity 30568.0 None 10.1021/jm0605740
Homo sapiens HT-29 Activity 3146605.0 None 10.1021/jm0605740
Homo sapiens HT-29 Activity 3926015.0 None 10.1021/jm0605740
Homo sapiens HT-29 Activity 3945095.0 None 10.1021/jm0605740
Homo sapiens HT-29 Activity 6151085.0 None 10.1021/jm0605740
Homo sapiens HT-29 Activity 6863365.0 None 10.1021/jm0605740
Homo sapiens HT-29 Activity 8258813.0 None 10.1021/jm0605740
Homo sapiens HT-29 Activity nan None 10.1021/jm0605740
Homo sapiens HT-29 GI50 6400.0 nM 10.1016/j.bmc.2011.08.051
Homo sapiens HT-29 GI50 19900.0 nM 10.1021/jm801340z
Homo sapiens HT-29 GI50 19952.62 nM 10.1021/jm801340z
Homo sapiens HT-29 GI50 19998.62 nM None
Homo sapiens HT-29 IC50 11630.0 nM 10.1016/j.bmcl.2012.08.117
Homo sapiens HT-29 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens HT-29 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens Huh-7 Activity 9.0 % 10.1016/j.bmc.2017.01.049
Homo sapiens Huh-7 Activity 16.0 % 10.1016/j.bmc.2017.01.049
Homo sapiens Huh-7 Activity 90.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens Huh-7 Activity nan None 10.1016/j.bmc.2017.01.049
Homo sapiens Huh-7 Activity_index 0.1 None 10.1016/j.bmc.2017.01.049
Homo sapiens Huh-7 Activity_index 0.3 None 10.1016/j.bmc.2017.01.049
Homo sapiens Huh-7 IC50 5000.0 nM 10.1016/j.bmc.2009.07.051
Homo sapiens Huh-7 IC50 9000.0 nM 10.1016/j.bmcl.2021.128390
Homo sapiens Huh-7 IC50 10000.0 nM 10.1016/j.ejmech.2011.08.048
Homo sapiens Huh-7 IC50 12000.0 nM 10.1016/j.ejmech.2012.09.001
Homo sapiens Huh-7 IC50 14000.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens Huh-7 IC50 15400.0 nM 10.1016/j.bmc.2017.01.049
Homo sapiens Huh-7 IC50 20000.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens HuTu80 IC50 310350.41 nM 10.6019/CHEMBL1201861
Homo sapiens HUVEC GI50 3700.0 nM 10.1021/jm100732t
Homo sapiens IGROV-1 GI50 5780.96 nM None
Homo sapiens IGROV-1 GI50 6300.0 nM 10.1021/jm801340z
Homo sapiens IGROV-1 GI50 6309.57 nM 10.1021/jm801340z
Homo sapiens IGROV-1 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens IGROV-1 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens IM-9 IC50 4134790.74 nM 10.6019/CHEMBL1201861
Homo sapiens IMR-32 IC50 17000.0 nM 10.1016/j.ejmech.2018.08.100
Homo sapiens IMR-5 IC50 35313.88 nM 10.6019/CHEMBL1201861
Homo sapiens Inactive serine/threonine-protein kinase VRK3 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Activity 80.0 % 10.1042/bj20070797
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Inhibitor of nuclear factor kappa B kinase epsilon subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Inosine-5'-monophosphate dehydrogenase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin-like growth factor I receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin-like growth factor I receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Insulin receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Insulin receptor Kd nan None 10.1038/nbt1068
Homo sapiens Insulin receptor-related protein Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Interleukin-1 receptor-associated kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Interleukin-1 receptor-associated kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Interleukin-1 receptor-associated kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Isoleucine--tRNA ligase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens IST-MEL1 IC50 146076.73 nM 10.6019/CHEMBL1201861
Homo sapiens IST-MES1 IC50 1095906.33 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL1 IC50 67643.75 nM 10.6019/CHEMBL1201861
Homo sapiens IST-SL2 IC50 24534.35 nM 10.6019/CHEMBL1201861
Homo sapiens JAR IC50 17015.23 nM 10.6019/CHEMBL1201861
Homo sapiens JIYOYE IC50 8502.64 nM 10.6019/CHEMBL1201861
Homo sapiens J-RT3-T3-5 IC50 64020.73 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-2 IC50 93717.13 nM 10.6019/CHEMBL1201861
Homo sapiens JVM-3 IC50 3699829.44 nM 10.6019/CHEMBL1201861
Homo sapiens K5 IC50 35086.06 nM 10.6019/CHEMBL1201861
Homo sapiens K562 GI50 50100.0 nM 10.1021/jm801340z
Homo sapiens K562 GI50 50118.72 nM 10.1021/jm801340z
Homo sapiens K562 GI50 52966.34 nM None
Homo sapiens K562 IC50 20000.0 nM 10.1021/jm100080z
Homo sapiens K562 IC50 30900.0 nM 10.1016/j.ejmech.2015.12.023
Homo sapiens K562 IC50 40000.0 nM 10.1016/s0960-894x(02)00693-5
Homo sapiens K562 IC50 40000.0 nM 10.1016/s0960-894x(03)00632-2
Homo sapiens K562 IC50 42000.0 nM 10.1016/j.bmc.2013.01.004
Homo sapiens K562 IC50 42000.0 nM 10.1016/j.bmc.2015.02.026
Homo sapiens K562 IC50 45500.0 nM 10.1016/j.bmcl.2016.05.004
Homo sapiens K562 IC50 45500.0 nM 10.1016/j.ejmech.2012.06.036
Homo sapiens K562 IC50 45500.0 nM 10.1016/j.ejmech.2013.08.009
Homo sapiens K562 IC50 45500.0 nM 10.1016/j.ejmech.2016.01.011
Homo sapiens K562 IC50 45500.0 nM 10.1021/jm4006884
Homo sapiens K562 IC50 130531.16 nM 10.6019/CHEMBL1201861
Homo sapiens K562 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens K562 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens KALS-1 IC50 71418.0 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-299 IC50 26864.62 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-422 IC50 9963.36 nM 10.6019/CHEMBL1201861
Homo sapiens KARPAS-45 IC50 574588.42 nM 10.6019/CHEMBL1201861
Homo sapiens Kasumi 1 IC50 3862743.65 nM 10.6019/CHEMBL1201861
Homo sapiens KB IC50 24600.0 nM 10.1016/j.ejmech.2015.04.062
Homo sapiens KB IC50 30100.0 nM 10.1021/jm100080z
Homo sapiens KE-37 IC50 93498.84 nM 10.6019/CHEMBL1201861
Homo sapiens KG-1 IC50 795144.61 nM 10.6019/CHEMBL1201861
Homo sapiens KGN IC50 34252.45 nM 10.6019/CHEMBL1201861
Homo sapiens KINGS-1 IC50 787988.9 nM 10.6019/CHEMBL1201861
Homo sapiens KM12 GI50 5010.0 nM 10.1021/jm801340z
Homo sapiens KM12 GI50 5011.87 nM 10.1021/jm801340z
Homo sapiens KM12 GI50 5260.17 nM None
Homo sapiens KM12 GI50 15000.0 nM 10.1016/j.bmc.2011.08.051
Homo sapiens KM12 IC50 29623.86 nM 10.6019/CHEMBL1201861
Homo sapiens KM12 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens KM12 TGI 63095.73 nM 10.1021/jm801340z
Homo sapiens KM12 TGI 63100.0 nM 10.1021/jm801340z
Homo sapiens KM-H2 IC50 1831458.64 nM 10.6019/CHEMBL1201861
Homo sapiens KMOE-2 IC50 171934.05 nM 10.6019/CHEMBL1201861
Homo sapiens KMS-12-PE IC50 1386464.14 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-42 IC50 72108.79 nM 10.6019/CHEMBL1201861
Homo sapiens KNS-81-FD IC50 78078.44 nM 10.6019/CHEMBL1201861
Homo sapiens KP-N-YS IC50 1751971.49 nM 10.6019/CHEMBL1201861
Homo sapiens KS-1 IC50 9457.85 nM 10.6019/CHEMBL1201861
Homo sapiens KU812 cell line IC50 69210.81 nM 10.6019/CHEMBL1201861
Homo sapiens KURAMOCHI IC50 26808.23 nM 10.6019/CHEMBL1201861
Homo sapiens KY821 IC50 231382.23 nM 10.6019/CHEMBL1201861
Homo sapiens L-363 IC50 914521.52 nM 10.6019/CHEMBL1201861
Homo sapiens L-428 IC50 704500.47 nM 10.6019/CHEMBL1201861
Homo sapiens L-540 IC50 155761.97 nM 10.6019/CHEMBL1201861
Homo sapiens LAMA-84 IC50 2640897.23 nM 10.6019/CHEMBL1201861
Homo sapiens LAN-6 IC50 158401.98 nM 10.6019/CHEMBL1201861
Homo sapiens LB1047-RCC IC50 158950.05 nM 10.6019/CHEMBL1201861
Homo sapiens LB2241-RCC IC50 48620.15 nM 10.6019/CHEMBL1201861
Homo sapiens LB2518-MEL IC50 47044.83 nM 10.6019/CHEMBL1201861
Homo sapiens LB373-MEL-D IC50 560842.99 nM 10.6019/CHEMBL1201861
Homo sapiens LB647-SCLC IC50 66308.76 nM 10.6019/CHEMBL1201861
Homo sapiens LB771-HNC IC50 48921.16 nM 10.6019/CHEMBL1201861
Homo sapiens LB831-BLC IC50 11562.35 nM 10.6019/CHEMBL1201861
Homo sapiens LB996-RCC IC50 59920.46 nM 10.6019/CHEMBL1201861
Homo sapiens LC-1F IC50 41570.47 nM 10.6019/CHEMBL1201861
Homo sapiens LC-2-ad IC50 363635.14 nM 10.6019/CHEMBL1201861
Homo sapiens LC4-1 IC50 18873.45 nM 10.6019/CHEMBL1201861
Homo sapiens Leukocyte tyrosine kinase receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens LIM domain kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens LIM domain kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens LIM domain kinase 1 Kd nan None 10.1038/nbt1068
Homo sapiens LIM domain kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens LIM domain kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Liver glycogen phosphorylase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens LNCaP-Clone-FGC IC50 1380352.25 nM 10.6019/CHEMBL1201861
Homo sapiens Long-chain-fatty-acid--CoA ligase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens LOUCY IC50 32125.3 nM 10.6019/CHEMBL1201861
Homo sapiens LOX IMVI GI50 12600.0 nM 10.1021/jm801340z
Homo sapiens LOX IMVI GI50 13995.87 nM None
Homo sapiens LOX IMVI GI50 19952.62 nM 10.1021/jm801340z
Homo sapiens LOX IMVI IC50 57569.45 nM 10.6019/CHEMBL1201861
Homo sapiens LOX IMVI LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens LOX IMVI TGI 50118.72 nM 10.1021/jm801340z
Homo sapiens LOX IMVI TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens LP-1 Activity 50.0 % 10.1158/0008-5472.can-05-0233
Homo sapiens LP-1 Activity 60.0 % 10.1158/0008-5472.can-05-0233
Homo sapiens LP-1 Activity nan None 10.1158/0008-5472.can-05-0233
Homo sapiens LP-1 FC 2.0 None 10.1158/0008-5472.can-05-0233
Homo sapiens LP-1 IC50 12680.0 nM 10.1158/0008-5472.can-05-0233
Homo sapiens LP-1 IC50 33890.81 nM 10.6019/CHEMBL1201861
Homo sapiens LS-1034 IC50 123979.1 nM 10.6019/CHEMBL1201861
Homo sapiens LS-123 IC50 197264.41 nM 10.6019/CHEMBL1201861
Homo sapiens LS-411N IC50 228842.04 nM 10.6019/CHEMBL1201861
Homo sapiens LS-513 IC50 23517.86 nM 10.6019/CHEMBL1201861
Homo sapiens LU-134-A IC50 272690.38 nM 10.6019/CHEMBL1201861
Homo sapiens LU-139 IC50 37185.65 nM 10.6019/CHEMBL1201861
Homo sapiens LU-165 IC50 514066.17 nM 10.6019/CHEMBL1201861
Homo sapiens Lu-65 IC50 238629.47 nM 10.6019/CHEMBL1201861
Homo sapiens LXF-289 cell line IC50 113370.14 nM 10.6019/CHEMBL1201861
Homo sapiens M14 GI50 12589.25 nM 10.1021/jm801340z
Homo sapiens M14 GI50 25100.0 nM 10.1021/jm801340z
Homo sapiens M14 GI50 27925.44 nM None
Homo sapiens M14 LC50 79432.82 nM 10.1021/jm801340z
Homo sapiens M14 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens M14 TGI 50118.72 nM 10.1021/jm801340z
Homo sapiens M14 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens Macrophage colony stimulating factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Macrophage-stimulating protein receptor Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Malme-3M GI50 19319.68 nM None
Homo sapiens Malme-3M GI50 19900.0 nM 10.1021/jm801340z
Homo sapiens Malme-3M GI50 25118.86 nM 10.1021/jm801340z
Homo sapiens Malme-3M LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens Malme-3M TGI 50100.0 nM 10.1021/jm801340z
Homo sapiens Malme-3M TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens MAP kinase-activated protein kinase 2 Activity 97.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 2 Delta TM -0.06 C None
Homo sapiens MAP kinase-activated protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase-activated protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-activated protein kinase 3 Activity 86.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 5 Activity 83.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-activated protein kinase 5 Inhibition 28.0 % 10.1021/jm200064p
Homo sapiens MAP kinase-activated protein kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase-activated protein kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase ERK1 Activity 82.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK1 IC50 34000.0 nM 10.1021/jm011002c
Homo sapiens MAP kinase ERK1 IC50 34000.0 nM 10.1073/pnas.0708800104
Homo sapiens MAP kinase ERK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase ERK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase ERK1 Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase ERK2 Activity 83.0 % 10.1042/bj20070797
Homo sapiens MAP kinase ERK2 Delta TM 0.41 C None
Homo sapiens MAP kinase ERK2 Delta TM 1.203 C None
Homo sapiens MAP kinase ERK2 IC50 14000.0 nM 10.1021/jm011002c
Homo sapiens MAP kinase ERK2 IC50 14000.0 nM 10.1073/pnas.0708800104
Homo sapiens MAP kinase ERK2 IC50 25000.0 nM 10.1016/j.bmc.2011.08.051
Homo sapiens MAP kinase ERK2 IC50 75000.0 nM 10.1021/acs.jmedchem.8b01541
Homo sapiens MAP kinase ERK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase ERK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Activity 90.0 % 10.1042/bj20070797
Homo sapiens MAP kinase-interacting serine/threonine-protein kinase MNK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 alpha Activity 96.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 alpha Delta TM -0.01 C None
Homo sapiens MAP kinase p38 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase p38 alpha Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase p38 beta Activity 94.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP kinase p38 beta Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase p38 beta Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens MAP kinase p38 delta Activity 92.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 delta Delta TM 0.49 C None
Homo sapiens MAP kinase p38 gamma Activity 99.0 % 10.1042/bj20070797
Homo sapiens MAP kinase p38 gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase p38 gamma Kd nan None 10.1038/nbt1068
Homo sapiens MAP kinase signal-integrating kinase 2 Activity 97.0 % 10.1042/bj20070797
Homo sapiens MAP kinase signal-integrating kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP kinase signal-integrating kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Delta TM 0.0 C None
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Delta TM -1.86 C None
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Delta TM -0.84 C None
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MAP/microtubule affinity-regulating kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Maternal embryonic leucine zipper kinase Activity 88.0 % 10.1042/bj20070797
Homo sapiens Maternal embryonic leucine zipper kinase Delta TM 0.9 C None
Homo sapiens Maternal embryonic leucine zipper kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Maternal embryonic leucine zipper kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens MC116 IC50 85282.14 nM 10.6019/CHEMBL1201861
Homo sapiens MC-CAR IC50 489089.26 nM 10.6019/CHEMBL1201861
Homo sapiens MCF-10A GI50 16300.0 nM 10.1021/jm100732t
Homo sapiens MCF7 Activity 6.56 % 10.1016/j.bmc.2011.02.052
Homo sapiens MCF7 Activity 7.13 % 10.1016/j.bmc.2011.02.052
Homo sapiens MCF7 Activity 13.2 % 10.1016/j.bmc.2011.02.052
Homo sapiens MCF7 Activity 73.12 % 10.1016/j.bmc.2011.02.052
Homo sapiens MCF7 Activity nan None 10.1021/jm200064p
Homo sapiens MCF7 GI50 7800.0 nM 10.1021/jm100732t
Homo sapiens MCF7 GI50 12600.0 nM 10.1021/jm801340z
Homo sapiens MCF7 GI50 13489.63 nM None
Homo sapiens MCF7 GI50 25118.86 nM 10.1021/jm801340z
Homo sapiens MCF7 IC50 3980.0 nM 10.1016/j.bmcl.2013.03.129
Homo sapiens MCF7 IC50 9000.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens MCF7 IC50 9000.0 nM 10.1016/j.bmcl.2021.128390
Homo sapiens MCF7 IC50 10200.0 nM 10.1016/j.bmc.2017.01.049
Homo sapiens MCF7 IC50 11000.0 nM 10.1016/j.bmc.2013.01.004
Homo sapiens MCF7 IC50 11000.0 nM 10.1016/j.bmc.2015.02.026
Homo sapiens MCF7 IC50 11000.0 nM 10.1016/j.ejmech.2015.11.043
Homo sapiens MCF7 IC50 11100.0 nM 10.1016/s0960-894x(02)00693-5
Homo sapiens MCF7 IC50 11100.0 nM 10.1016/s0960-894x(03)00632-2
Homo sapiens MCF7 IC50 12220.0 nM 10.1016/j.bmcl.2012.08.117
Homo sapiens MCF7 IC50 12250.0 nM 10.1016/j.ejmech.2016.01.011
Homo sapiens MCF7 IC50 12300.0 nM 10.1016/j.bmcl.2016.05.004
Homo sapiens MCF7 IC50 12300.0 nM 10.1016/j.ejmech.2012.06.036
Homo sapiens MCF7 IC50 12300.0 nM 10.1016/j.ejmech.2013.08.009
Homo sapiens MCF7 IC50 12300.0 nM 10.1021/jm4006884
Homo sapiens MCF7 IC50 14700.0 nM 10.1021/jm100080z
Homo sapiens MCF7 IC50 19600.0 nM 10.1016/j.ejmech.2015.04.062
Homo sapiens MCF7 IC50 20200.0 nM 10.1016/j.ejmech.2013.01.021
Homo sapiens MCF7 IC50 27200.0 nM 10.1016/j.ejmech.2015.12.023
Homo sapiens MCF7 IC50 55010.0 nM 10.1016/j.bmc.2011.02.052
Homo sapiens MCF7 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens MCF7 Ratio 1.5 None 10.1016/j.ejmech.2013.01.021
Homo sapiens MCF7 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens MDA-MB-134-VI IC50 220192.9 nM 10.6019/CHEMBL1201861
Homo sapiens MDA-MB-231 Activity 25.0 % 10.1016/j.bmc.2017.01.049
Homo sapiens MDA-MB-231 Activity 27.0 % 10.1016/j.bmc.2017.01.049
Homo sapiens MDA-MB-231 Activity 80.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens MDA-MB-231 Activity nan None 10.1016/j.bmc.2011.02.052
Homo sapiens MDA-MB-231 Activity nan None 10.1016/j.bmc.2017.01.049
Homo sapiens MDA-MB-231 Activity_index 0.0 None 10.1016/j.bmc.2017.01.049
Homo sapiens MDA-MB-231 Activity_index 0.5 None 10.1016/j.bmc.2017.01.049
Homo sapiens MDA-MB-231 GI50 12589.25 nM 10.1021/jm801340z
Homo sapiens MDA-MB-231 GI50 22600.0 nM 10.1021/jm100732t
Homo sapiens MDA-MB-231 GI50 39719.15 nM None
Homo sapiens MDA-MB-231 GI50 39800.0 nM 10.1021/jm801340z
Homo sapiens MDA-MB-231 IC50 3000.0 nM 10.1016/j.ejmech.2015.06.046
Homo sapiens MDA-MB-231 IC50 3000.0 nM 10.1016/j.ejmech.2016.02.072
Homo sapiens MDA-MB-231 IC50 12000.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens MDA-MB-231 IC50 12000.0 nM 10.1016/j.ejmech.2012.09.001
Homo sapiens MDA-MB-231 IC50 15000.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens MDA-MB-231 IC50 15000.0 nM 10.1016/j.ejmech.2011.08.048
Homo sapiens MDA-MB-231 IC50 15000.0 nM 10.1016/j.ejmech.2019.111641
Homo sapiens MDA-MB-231 IC50 15000.0 nM 10.1021/acs.jnatprod.5b01073
Homo sapiens MDA-MB-231 IC50 16800.0 nM 10.1016/j.bmc.2017.01.049
Homo sapiens MDA-MB-231 IC50 17000.0 nM 10.1016/j.bmcl.2021.128390
Homo sapiens MDA-MB-231 IC50 54640.0 nM 10.1016/j.bmc.2011.02.052
Homo sapiens MDA-MB-231 LC50 79432.82 nM 10.1021/jm801340z
Homo sapiens MDA-MB-231 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens MDA-MB-231 TGI 12589.25 nM 10.1021/jm801340z
Homo sapiens MDA-MB-231 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens MDA-MB-435 GI50 12600.0 nM 10.1021/jm801340z
Homo sapiens MDA-MB-435 GI50 13273.94 nM None
Homo sapiens MDA-MB-435 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens MDA-MB-435 TGI 50100.0 nM 10.1021/jm801340z
Homo sapiens MDA-MB-468 GI50 25118.86 nM 10.1021/jm801340z
Homo sapiens MDA-MB-468 GI50 nan None 10.1021/jm801340z
Homo sapiens MDA-MB-468 IC50 18000.0 nM 10.1016/j.bmcl.2021.128390
Homo sapiens MDA-MB-468 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens MDA-MB-468 LC50 nan None 10.1021/jm801340z
Homo sapiens MDA-MB-468 TGI nan None 10.1021/jm801340z
Homo sapiens MEG-01 IC50 13837.88 nM 10.6019/CHEMBL1201861
Homo sapiens MFH-ino IC50 164277.16 nM 10.6019/CHEMBL1201861
Homo sapiens MFM-223 IC50 1846263.23 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-CALL-2 IC50 322126.72 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-NB-11 IC50 73389.58 nM 10.6019/CHEMBL1201861
Homo sapiens MHH-PREB-1 IC50 20035.63 nM 10.6019/CHEMBL1201861
Homo sapiens MIA PaCa-2 IC50 18214.0 nM 10.1016/j.bmcl.2018.10.020
Homo sapiens Midasin Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase 15 Activity 40.0 % 10.1042/bj20070797
Homo sapiens Mitogen-activated protein kinase 15 Delta TM 3.16 C None
Homo sapiens Mitogen-activated protein kinase 15 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 15 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 6 Thermal melting change -0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 10 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 4 Kd nan None 10.1038/nbt1068
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Delta TM 0.0 C None
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Mitogen-activated protein kinase kinase kinase 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 5 Kd nan None 10.1038/nbt1068
Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Mixed lineage kinase 7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Mixed lineage kinase 7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens ML-2 IC50 37671.17 nM 10.6019/CHEMBL1201861
Homo sapiens MLMA IC50 42278.68 nM 10.6019/CHEMBL1201861
Homo sapiens MMAC-SF IC50 422989.77 nM 10.6019/CHEMBL1201861
Homo sapiens MN-60 IC50 487530.57 nM 10.6019/CHEMBL1201861
Homo sapiens Mo IC50 947719.91 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-16 IC50 163948.44 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 GI50 25100.0 nM 10.1021/jm801340z
Homo sapiens MOLT-4 GI50 25118.86 nM 10.1021/jm801340z
Homo sapiens MOLT-4 GI50 25118.86 nM None
Homo sapiens MOLT-4 IC50 36327.57 nM 10.6019/CHEMBL1201861
Homo sapiens MOLT-4 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens MOLT-4 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens MONO-MAC-6 IC50 38247.72 nM 10.6019/CHEMBL1201861
Homo sapiens MPP-89 IC50 255825.87 nM 10.6019/CHEMBL1201861
Homo sapiens MRK-nu-1 IC50 7129.69 nM 10.6019/CHEMBL1201861
Homo sapiens MS-1 IC50 42892.97 nM 10.6019/CHEMBL1201861
Homo sapiens MSTO-211H IC50 1903177.24 nM 10.6019/CHEMBL1201861
Homo sapiens Multifunctional protein ADE2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens MV4-11 IC50 105590.46 nM 10.6019/CHEMBL1201861
Homo sapiens Myosin-10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin-14 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myosin IIIA Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin-IIIB Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin light chain kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens myosin light chain kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens myosin light chain kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Myosin light chain kinase family member 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin light chain kinase, smooth muscle Activity 84.0 % 10.1042/bj20070797
Homo sapiens Myosin light chain kinase, smooth muscle Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myosin light chain kinase, smooth muscle Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Myotonin-protein kinase Delta TM -1.29 C None
Homo sapiens Myotonin-protein kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Myotonin-protein kinase Thermal melting change -0.7 degrees C 10.1073/pnas.0708800104
Homo sapiens MZ1-PC IC50 1116559.1 nM 10.6019/CHEMBL1201861
Homo sapiens MZ2-MEL IC50 553126.65 nM 10.6019/CHEMBL1201861
Homo sapiens MZ7-mel IC50 762104.74 nM 10.6019/CHEMBL1201861
Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens NALM-6 IC50 77040.4 nM 10.6019/CHEMBL1201861
Homo sapiens NB1 IC50 12330.75 nM 10.6019/CHEMBL1201861
Homo sapiens NB10 IC50 55603.6 nM 10.6019/CHEMBL1201861
Homo sapiens NB12 IC50 848063.91 nM 10.6019/CHEMBL1201861
Homo sapiens NB13 IC50 1151643.12 nM 10.6019/CHEMBL1201861
Homo sapiens NB14 IC50 2022490.6 nM 10.6019/CHEMBL1201861
Homo sapiens NB17 IC50 163480.55 nM 10.6019/CHEMBL1201861
Homo sapiens NB5 IC50 256416.74 nM 10.6019/CHEMBL1201861
Homo sapiens NB6 IC50 977399.04 nM 10.6019/CHEMBL1201861
Homo sapiens NB69 IC50 3271124.21 nM 10.6019/CHEMBL1201861
Homo sapiens NB7 IC50 489817.07 nM 10.6019/CHEMBL1201861
Homo sapiens NCCIT IC50 7554.82 nM 10.6019/CHEMBL1201861
Homo sapiens NCI/ADR-RES GI50 6300.0 nM 10.1021/jm801340z
Homo sapiens NCI/ADR-RES GI50 6966.27 nM None
Homo sapiens NCI/ADR-RES LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens NCI/ADR-RES TGI 63100.0 nM 10.1021/jm801340z
Homo sapiens NCI-H1092 IC50 69677.19 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1155 IC50 54319.87 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H128 IC50 3515053.41 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1304 IC50 16360.13 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1355 IC50 72450.97 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1395 IC50 630305.11 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1417 IC50 831094.08 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1436 IC50 534165.12 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1522 IC50 124614.88 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1581 IC50 101747.68 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1648 IC50 157184.3 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1650 IC50 2627163.43 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1694 IC50 119199.31 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1770 IC50 1559987.36 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1838 IC50 657700.07 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H187 IC50 361473.6 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1882 IC50 40599.79 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H1963 IC50 56454.89 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2081 IC50 291494.17 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H209 IC50 46011.53 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2107 IC50 109311.87 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2126 IC50 25652.88 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2141 IC50 34653.34 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2171 IC50 159236.9 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2196 IC50 155583.88 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H2227 IC50 2388232.9 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H226 GI50 19186.69 nM None
Homo sapiens NCI-H226 GI50 19900.0 nM 10.1021/jm801340z
Homo sapiens NCI-H226 GI50 19952.62 nM 10.1021/jm801340z
Homo sapiens NCI-H226 IC50 705405.63 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H226 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens NCI-H226 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens NCI-H23 GI50 12589.25 nM 10.1021/jm801340z
Homo sapiens NCI-H23 GI50 12600.0 nM 10.1021/jm801340z
Homo sapiens NCI-H23 GI50 13152.25 nM None
Homo sapiens NCI-H23 IC50 2970349.79 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H23 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens NCI-H23 TGI 50100.0 nM 10.1021/jm801340z
Homo sapiens NCI-H23 TGI 50118.72 nM 10.1021/jm801340z
Homo sapiens NCI-H322M GI50 29376.5 nM None
Homo sapiens NCI-H322M GI50 31600.0 nM 10.1021/jm801340z
Homo sapiens NCI-H322M GI50 31622.78 nM 10.1021/jm801340z
Homo sapiens NCI-H322M IC50 229043.51 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H322M LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens NCI-H322M TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens NCI-H345 IC50 38910.65 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H446 IC50 1310157.97 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H460 Activity 3.09 % 10.1016/j.ejmech.2020.112322
Homo sapiens NCI-H460 Activity 14.0 % 10.1016/j.ejmech.2020.112322
Homo sapiens NCI-H460 Activity 36.0 % 10.1016/j.ejmech.2020.112322
Homo sapiens NCI-H460 Activity 47.0 % 10.1016/j.ejmech.2020.112322
Homo sapiens NCI-H460 GI50 25100.0 nM 10.1021/jm801340z
Homo sapiens NCI-H460 GI50 25118.86 nM 10.1021/jm801340z
Homo sapiens NCI-H460 GI50 27861.21 nM None
Homo sapiens NCI-H460 IC50 11600.0 nM 10.1016/j.ejmech.2015.04.062
Homo sapiens NCI-H460 IC50 11900.0 nM 10.1016/j.ejmech.2020.112322
Homo sapiens NCI-H460 Inhibition 7.73 % 10.1016/j.ejmech.2020.112322
Homo sapiens NCI-H460 Inhibition 15.56 % 10.1016/j.ejmech.2020.112322
Homo sapiens NCI-H460 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens NCI-H460 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens NCI-H510A IC50 30032.86 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H522 GI50 15800.0 nM 10.1021/jm801340z
Homo sapiens NCI-H522 GI50 15848.93 nM 10.1021/jm801340z
Homo sapiens NCI-H522 GI50 16368.17 nM None
Homo sapiens NCI-H522 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens NCI-H522 TGI 63095.73 nM 10.1021/jm801340z
Homo sapiens NCI-H522 TGI 63100.0 nM 10.1021/jm801340z
Homo sapiens NCI-H524 IC50 61357.78 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H526 IC50 33493.62 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H64 IC50 33859.72 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H69 IC50 907720.04 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H716 IC50 4070874.01 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H719 IC50 576484.82 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H720 IC50 335973.74 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H727 Activity 40.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens NCI-H727 Activity nan None 10.1016/j.bmc.2017.01.049
Homo sapiens NCI-H727 IC50 4000.0 nM 10.1016/j.ejmech.2015.06.046
Homo sapiens NCI-H727 IC50 4000.0 nM 10.1016/j.ejmech.2016.02.072
Homo sapiens NCI-H727 IC50 20000.0 nM 10.1016/j.bmc.2017.01.049
Homo sapiens NCI-H727 IC50 20000.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens NCI-H727 IC50 20000.0 nM 10.1016/j.ejmech.2012.09.001
Homo sapiens NCI-H727 IC50 28000.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens NCI-H747 IC50 245147.48 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H748 IC50 263974.37 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H82 IC50 31013.48 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H889 IC50 885930.05 nM 10.6019/CHEMBL1201861
Homo sapiens NCI-H929 Activity 60.0 % 10.1158/0008-5472.can-05-0233
Homo sapiens NCI-H929 Activity nan None 10.1158/0008-5472.can-05-0233
Homo sapiens NCI-H929 FC 2.0 None 10.1158/0008-5472.can-05-0233
Homo sapiens NEC8 IC50 111724.94 nM 10.6019/CHEMBL1201861
Homo sapiens Nerve growth factor receptor Trk-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Nerve growth factor receptor Trk-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Nerve growth factor receptor Trk-A Kd nan None 10.1038/nbt1068
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NH-12 IC50 1424380.13 nM 10.6019/CHEMBL1201861
Homo sapiens NKM-1 IC50 31139.75 nM 10.6019/CHEMBL1201861
Homo sapiens NMC-G1 IC50 50928.62 nM 10.6019/CHEMBL1201861
Homo sapiens no-10 IC50 87895.71 nM 10.6019/CHEMBL1201861
Homo sapiens no-11 IC50 215862.58 nM 10.6019/CHEMBL1201861
Homo sapiens NOMO-1 IC50 21200.8 nM 10.6019/CHEMBL1201861
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Non-receptor tyrosine-protein kinase TNK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens NOS-1 IC50 28973.31 nM 10.6019/CHEMBL1201861
Homo sapiens NT-3 growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NTERA-2-cl-D1 IC50 39584.24 nM 10.6019/CHEMBL1201861
Homo sapiens NUAK family SNF1-like kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NUAK family SNF1-like kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens NUAK family SNF1-like kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Nucleolar GTP-binding protein 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Obg-like ATPase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens OCI-AML2 IC50 15648.22 nM 10.6019/CHEMBL1201861
Homo sapiens OCUB-M IC50 215710.45 nM 10.6019/CHEMBL1201861
Homo sapiens OMC-1 IC50 1803656.01 nM 10.6019/CHEMBL1201861
Homo sapiens ONS-76 IC50 262492.63 nM 10.6019/CHEMBL1201861
Homo sapiens OPM-2 IC50 18460.0 nM 10.1158/0008-5472.can-05-0233
Homo sapiens OPM-2 IC50 37294.95 nM 10.6019/CHEMBL1201861
Homo sapiens OS-RC-2 IC50 15838.22 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-3 GI50 11455.13 nM None
Homo sapiens OVCAR-3 GI50 12589.25 nM 10.1021/jm801340z
Homo sapiens OVCAR-3 GI50 12600.0 nM 10.1021/jm801340z
Homo sapiens OVCAR-3 IC50 37000.0 nM 10.1016/j.ejmech.2018.08.100
Homo sapiens OVCAR-3 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens OVCAR-3 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens OVCAR-4 GI50 31600.0 nM 10.1021/jm801340z
Homo sapiens OVCAR-4 GI50 31622.78 nM 10.1021/jm801340z
Homo sapiens OVCAR-4 GI50 35156.04 nM None
Homo sapiens OVCAR-4 IC50 460315.44 nM 10.6019/CHEMBL1201861
Homo sapiens OVCAR-4 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens OVCAR-4 TGI 63095.73 nM 10.1021/jm801340z
Homo sapiens OVCAR-4 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens OVCAR-5 GI50 39800.0 nM 10.1021/jm801340z
Homo sapiens OVCAR-5 GI50 39810.72 nM 10.1021/jm801340z
Homo sapiens OVCAR-5 GI50 42756.29 nM None
Homo sapiens OVCAR-5 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens OVCAR-5 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens OVCAR-8 GI50 nan None 10.1021/jm801340z
Homo sapiens OVCAR-8 LC50 nan None 10.1021/jm801340z
Homo sapiens OVCAR-8 TGI nan None 10.1021/jm801340z
Homo sapiens P30-OHK IC50 2492757.98 nM 10.6019/CHEMBL1201861
Homo sapiens P31-FUJ IC50 3063548.0 nM 10.6019/CHEMBL1201861
Homo sapiens Panel breast (Carcinoma cell lines) GI50 22700.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel breast (Carcinoma cell lines) LC50 94900.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel breast (Carcinoma cell lines) TGI 73000.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel CNS (Carcinoma cell lines) GI50 24700.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel CNS (Carcinoma cell lines) LC50 100000.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel CNS (Carcinoma cell lines) TGI 82200.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel colon (Carcinoma cell lines) GI50 24800.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel colon (Carcinoma cell lines) LC50 100000.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel colon (Carcinoma cell lines) TGI 84900.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel leukemia (Carcinoma cell lines) GI50 37500.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel leukemia (Carcinoma cell lines) LC50 100000.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel leukemia (Carcinoma cell lines) TGI 100000.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel melanoma (Carcinoma cell lines) GI50 14800.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel melanoma (Carcinoma cell lines) LC50 97100.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel melanoma (Carcinoma cell lines) TGI 57600.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel ovarian (Carcinoma cell lines) GI50 29300.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel ovarian (Carcinoma cell lines) LC50 100000.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel ovarian (Carcinoma cell lines) TGI 93800.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel prostate (Carcinoma cell lines) GI50 17900.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel prostate (Carcinoma cell lines) LC50 100000.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel prostate (Carcinoma cell lines) TGI 81500.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel renal (Carcinoma cell lines) GI50 24900.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel renal (Carcinoma cell lines) LC50 100000.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens Panel renal (Carcinoma cell lines) TGI 97000.0 nM 10.1016/j.ejmech.2016.09.093
Homo sapiens PAS domain-containing serine/threonine-protein kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens PC-3 Activity 8.0 % 10.1016/j.bmcl.2018.12.050
Homo sapiens PC-3 Activity 17.0 % 10.1016/j.bmc.2017.01.049
Homo sapiens PC-3 Activity 38.0 % 10.1016/j.bmc.2017.01.049
Homo sapiens PC-3 Activity nan None 10.1016/j.bmc.2017.01.049
Homo sapiens PC-3 Activity_index 1.3 None 10.1016/j.bmc.2017.01.049
Homo sapiens PC-3 Activity_index 1.9 None 10.1016/j.bmc.2017.01.049
Homo sapiens PC-3 FC 0.797 None 10.1038/nchembio790
Homo sapiens PC-3 GI50 12589.25 nM 10.1021/jm801340z
Homo sapiens PC-3 GI50 19900.0 nM 10.1021/jm801340z
Homo sapiens PC-3 GI50 19906.73 nM None
Homo sapiens PC-3 GI50 25200.0 nM 10.1021/jm100732t
Homo sapiens PC-3 IC50 2000.0 nM 10.1016/j.ejmech.2015.06.046
Homo sapiens PC-3 IC50 8000.0 nM 10.1016/j.bmc.2009.07.051
Homo sapiens PC-3 IC50 8000.0 nM 10.1016/j.ejmech.2011.08.048
Homo sapiens PC-3 IC50 10000.0 nM 10.1016/j.bmc.2020.115962
Homo sapiens PC-3 IC50 10000.0 nM 10.1016/j.ejmech.2012.09.001
Homo sapiens PC-3 IC50 11000.0 nM 10.1016/j.bmcl.2021.128390
Homo sapiens PC-3 IC50 12000.0 nM 10.1016/j.bmcl.2018.12.050
Homo sapiens PC-3 IC50 12000.0 nM 10.1021/acs.jnatprod.5b01073
Homo sapiens PC-3 IC50 16500.0 nM 10.1016/j.bmc.2017.01.049
Homo sapiens PC-3 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens PC-3 TGI 63100.0 nM 10.1021/jm801340z
Homo sapiens PC-3 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens PDZ-binding kinase Thermal melting change 0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Peregrin Delta TM -1.38 C None
Homo sapiens Peregrin Delta TM 1.328 C None
Homo sapiens Peripheral myelin protein 22 Potency 37933.0 nM None
Homo sapiens Peripheral plasma membrane protein CASK Delta TM -0.14 C None
Homo sapiens Peroxisomal acyl-coenzyme A oxidase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Peroxisomal acyl-coenzyme A oxidase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens PF-382 IC50 50966.93 nM 10.6019/CHEMBL1201861
Homo sapiens P-glycoprotein 1 Ratio 3.399 None 10.1021/acs.jmedchem.0c02011
Homo sapiens Phenylalanine--tRNA ligase beta subunit Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylethanolamine-binding protein 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphofructokinase platelet type Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphorylase kinase gamma subunit 1 Kd nan None 10.1038/nbt1068
Homo sapiens Phosphorylase kinase gamma subunit 2 Delta TM 1.49 C None
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Phosphorylase kinase gamma subunit 2 Kd nan None 10.1038/nbt1068
Homo sapiens PI3-kinase p110-alpha/p85-alpha IC50 nan None 10.1016/j.ejmech.2012.09.001
Homo sapiens PI3-kinase p110-alpha subunit IC50 nan None 10.1016/j.ejmech.2012.09.001
Homo sapiens PI3-kinase p110-alpha subunit Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PITSLRE serine/threonine-protein kinase CDC2L2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Platelet-derived growth factor receptor alpha Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Platelet-derived growth factor receptor beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Platelet-derived growth factor receptor beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Platelet-derived growth factor receptor beta Kd nan None 10.1038/nbt1068
Homo sapiens Prelamin-A/C Potency 17782.8 nM None
Homo sapiens Prelamin-A/C Potency 22387.2 nM None
Homo sapiens Probable ATP-dependent RNA helicase DDX6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C alpha Activity 89.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C alpha Kd nan None 10.1038/nbt1068
Homo sapiens Protein kinase C beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C delta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C delta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C epsilon Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C eta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C iota Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C mu Activity 90.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C mu Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C nu Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C nu Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C theta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase C theta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase C zeta Activity 82.0 % 10.1042/bj20070797
Homo sapiens Protein kinase C zeta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase N1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase N1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein kinase N2 Activity 89.0 % 10.1042/bj20070797
Homo sapiens Protein kinase N2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein kinase N2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Protein tyrosine kinase 2 beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Protein tyrosine kinase 2 beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Delta TM -1.06 C None
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens PSN1 IC50 427385.75 nM 10.6019/CHEMBL1201861
Homo sapiens Putative heat shock protein HSP 90-beta 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Pyridoxal kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens QIMR-WIL IC50 27914.44 nM 10.6019/CHEMBL1201861
Homo sapiens Quinone reductase 2 Delta TM -0.8 C None
Homo sapiens Quinone reductase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rab-like protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Raji IC50 13789.44 nM 10.6019/CHEMBL1201861
Homo sapiens Ramos-2G6-4C10 IC50 97742.94 nM 10.6019/CHEMBL1201861
Homo sapiens Ras-related protein Rab-10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ras-related protein Rab-27A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens RCC10RGB IC50 392068.67 nM 10.6019/CHEMBL1201861
Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Receptor-interacting serine/threonine-protein kinase 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Receptor protein-tyrosine kinase erbB-2 Kd nan None 10.1038/nbt1068
Homo sapiens REH IC50 1288588.87 nM 10.6019/CHEMBL1201861
Homo sapiens Retinoblastoma-associated protein Inhibition nan % 10.1021/jm200064p
Homo sapiens RH-1 IC50 592673.7 nM 10.6019/CHEMBL1201861
Homo sapiens Rho-associated protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Rho-associated protein kinase 2 Activity 90.0 % 10.1042/bj20070797
Homo sapiens Rho-associated protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase 1 Activity 90.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 1 Activity 97.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 1 Delta TM 0.45 C None
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 3200.0 nM 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 3 Activity 71.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 3 Kd nan None 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change 1.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 3 Thermal melting change 1.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 5 Activity 78.0 % 10.1042/bj20070797
Homo sapiens Ribosomal protein S6 kinase alpha 5 Delta TM 0.46 C None
Homo sapiens Ribosomal protein S6 kinase alpha 5 Inhibition 29.0 % 10.1021/jm200064p
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Ribosomal protein S6 kinase alpha 5 Kd nan None 10.1038/nbt1068
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Ribosomal protein S6 kinase alpha 6 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens RKO IC50 33596.87 nM 10.6019/CHEMBL1201861
Homo sapiens RL IC50 900.0 nM 10.1016/j.bmc.2017.01.049
Homo sapiens RL IC50 3550039.47 nM 10.6019/CHEMBL1201861
Homo sapiens RL95-2 IC50 82234.34 nM 10.6019/CHEMBL1201861
Homo sapiens RNA cytidine acetyltransferase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens RPMI-6666 IC50 13912.09 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8226 Activity 60.0 % 10.1158/0008-5472.can-05-0233
Homo sapiens RPMI-8226 Activity nan None 10.1021/jm200064p
Homo sapiens RPMI-8226 Activity nan None 10.1158/0008-5472.can-05-0233
Homo sapiens RPMI-8226 GI50 24154.61 nM None
Homo sapiens RPMI-8226 IC50 111476.52 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI 8402 IC50 13626.18 nM 10.6019/CHEMBL1201861
Homo sapiens RPMI-8866 IC50 1325586.13 nM 10.6019/CHEMBL1201861
Homo sapiens RS4-11 IC50 37706.93 nM 10.6019/CHEMBL1201861
Homo sapiens RXF 393 GI50 4897.79 nM None
Homo sapiens RXF 393 GI50 5000.0 nM 10.1021/jm801340z
Homo sapiens RXF 393 GI50 6309.57 nM 10.1021/jm801340z
Homo sapiens RXF 393 IC50 288118.25 nM 10.6019/CHEMBL1201861
Homo sapiens RXF 393 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens RXF 393 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens S-adenosylmethionine synthase isoform type-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens SAOS-2 GI50 13900.0 nM 10.1021/jm100732t
Homo sapiens SBC-1 IC50 489497.82 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-15 IC50 351370.07 nM 10.6019/CHEMBL1201861
Homo sapiens SCC-3 IC50 14295.59 nM 10.6019/CHEMBL1201861
Homo sapiens SCH IC50 134636.02 nM 10.6019/CHEMBL1201861
Homo sapiens SCLC-21H IC50 325330.31 nM 10.6019/CHEMBL1201861
Homo sapiens Septin-9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 10 Delta TM -1.8 C None
Homo sapiens Serine/threonine-protein kinase 10 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 10 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 10 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 10 Thermal melting change 0.9 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 11 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 11 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 16 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 16 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 16 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 16 Thermal melting change 0.8 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 17A Delta TM -0.42 C None
Homo sapiens Serine/threonine-protein kinase 17A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 17A Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 17A Thermal melting change -0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 17B Delta TM -0.86 C None
Homo sapiens Serine/threonine-protein kinase 17B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 17B Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 2 Delta TM -1.29 C None
Homo sapiens Serine/threonine-protein kinase 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 2 Thermal melting change 0.2 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 24 Delta TM -0.1 C None
Homo sapiens Serine/threonine-protein kinase 24 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 24 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase 25 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 25 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 32B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 32C Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 33 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 36 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 36 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase 38 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase 38-like Delta TM -0.59 C None
Homo sapiens Serine/threonine-protein kinase 38-like Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase 38-like Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase AKT Activity 100.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT2 Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase AKT3 Delta TM 0.38 C None
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase AKT3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase A-Raf Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-A Delta TM -0.68 C None
Homo sapiens Serine/threonine-protein kinase Aurora-A Delta TM 0.2757 C None
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-A Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase Aurora-B Activity 94.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-B Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Aurora-C Activity 96.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Aurora-C Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase B-raf Delta TM 0.27 C None
Homo sapiens Serine/threonine-protein kinase B-raf Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase B-raf Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Chk1 Activity 87.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Chk1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Chk2 Activity 93.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase Chk2 Delta TM 1.19 C None
Homo sapiens Serine/threonine-protein kinase Chk2 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase c-TAK1 Activity 87.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase c-TAK1 Delta TM -1.45 C None
Homo sapiens Serine/threonine-protein kinase c-TAK1 Delta TM -0.84 C None
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase c-TAK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase D2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase D2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase DCLK1 Delta TM -1.56 C None
Homo sapiens Serine/threonine-protein kinase DCLK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase DCLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase EEF2K Activity 85.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase/endoribonuclease IRE2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase GAK Delta TM 0.55 C None
Homo sapiens Serine/threonine-protein kinase GAK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase GAK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase GAK Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase haspin Delta TM -0.21 C None
Homo sapiens Serine/threonine-protein kinase ICK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ILK-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase LATS1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase LATS2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MARK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK-A Delta TM -1.25 C None
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK-A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK beta Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MRCK gamma Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST1 Delta TM 0.63 C None
Homo sapiens Serine/threonine-protein kinase MST1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase MST1 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST2 Activity 95.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase MST2 Delta TM -0.37 C None
Homo sapiens Serine/threonine-protein kinase MST2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST4 Delta TM -0.14 C None
Homo sapiens Serine/threonine-protein kinase MST4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase MST4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase MST4 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase N3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek1 Delta TM 0.43 C None
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase Nek1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK2 Activity 85.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK2 Delta TM 1.01 C None
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase NEK2 Thermal melting change 0.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase Nek3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase Nek5 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK6 Activity 92.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK6 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase NEK6 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase NEK7 Activity 87.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase NEK7 Delta TM -1.38 C None
Homo sapiens Serine/threonine-protein kinase NEK7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK7 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase NEK9 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase NEK9 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine protein kinase NLK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine protein kinase NLK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase OSR1 Delta TM 0.8 C None
Homo sapiens Serine/threonine-protein kinase OSR1 Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK 1 Delta TM -0.67 C None
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 3 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 4 Activity 90.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK 4 Delta TM 1.62 C None
Homo sapiens Serine/threonine-protein kinase PAK 4 IC50 6900.0 nM 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 5024.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK 4 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK 4 Thermal melting change 1.7 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK6 Activity 80.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK6 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK6 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK6 Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PAK7 Activity 74.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PAK7 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PAK7 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PAK7 Thermal melting change 0.6 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Delta TM 1.08 C None
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 990.0 nM 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PCTAIRE-1 Thermal melting change -0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PCTAIRE-2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PCTAIRE-3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PFTAIRE-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM1 Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM1 Delta TM 0.64 C None
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PIM1 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PIM1 Thermal melting change -1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM2 Activity 106.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PIM2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PIM2 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PIM3 Activity 83.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PIM3 Delta TM -0.76 C None
Homo sapiens Serine/threonine-protein kinase PIM3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PIM3 Thermal melting change 0.5 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK1 Activity 91.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase PLK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PLK1 Thermal melting change 1.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PLK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK4 Delta TM 0.15 C None
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase PLK4 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase PLK4 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase PLK4 Thermal melting change 0.3 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase PRKX Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RAF Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase receptor R3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIO1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIO2 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase RIO3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase RIPK2 Kd nan None 10.1038/nbt1068
Homo sapiens Serine/threonine-protein kinase Sgk1 Activity 75.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase SIK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SIK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase SIK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase SRPK1 Activity 84.0 % 10.1042/bj20070797
Homo sapiens Serine/threonine-protein kinase SRPK1 Delta TM 3.06 C None
Homo sapiens Serine/threonine-protein kinase SRPK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SRPK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase SRPK3 Delta TM 0.87 C None
Homo sapiens Serine/threonine-protein kinase TAO1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TAO3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TBK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase TNNI3K Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase tousled-like 1 Delta TM -1.68 C None
Homo sapiens Serine/threonine-protein kinase tousled-like 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase ULK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase ULK3 Delta TM 2.07 C None
Homo sapiens Serine/threonine-protein kinase ULK3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase VRK1 Delta TM 0.41 C None
Homo sapiens Serine/threonine-protein kinase VRK1 Thermal melting change 0.0 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase VRK2 Thermal melting change 2.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Serine/threonine-protein kinase WEE1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Serine/threonine-protein kinase WNK1 Delta TM 0.0 C None
Homo sapiens SF-126 IC50 98232.98 nM 10.6019/CHEMBL1201861
Homo sapiens SF-268 GI50 19815.27 nM None
Homo sapiens SF-268 GI50 19900.0 nM 10.1021/jm801340z
Homo sapiens SF-268 GI50 19952.62 nM 10.1021/jm801340z
Homo sapiens SF-268 IC50 8800.0 nM 10.1016/j.ejmech.2015.04.062
Homo sapiens SF-268 IC50 131690.04 nM 10.6019/CHEMBL1201861
Homo sapiens SF-268 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens SF-268 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens SF-295 GI50 25100.0 nM 10.1021/jm801340z
Homo sapiens SF-295 GI50 25118.86 nM 10.1021/jm801340z
Homo sapiens SF-295 GI50 25527.01 nM None
Homo sapiens SF-295 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens SF-295 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens SF-539 GI50 15776.11 nM None
Homo sapiens SF-539 GI50 15800.0 nM 10.1021/jm801340z
Homo sapiens SF-539 GI50 15848.93 nM 10.1021/jm801340z
Homo sapiens SF-539 IC50 823093.66 nM 10.6019/CHEMBL1201861
Homo sapiens SF-539 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens SF-539 TGI 79400.0 nM 10.1021/jm801340z
Homo sapiens SF-539 TGI 79432.82 nM 10.1021/jm801340z
Homo sapiens SH-4 IC50 128960.48 nM 10.6019/CHEMBL1201861
Homo sapiens SHP77 IC50 124538.39 nM 10.6019/CHEMBL1201861
Homo sapiens SH-SY5Y IC50 41.0 nM 10.1016/j.ejmech.2019.01.003
Homo sapiens SH-SY5Y IC50 16100.0 nM 10.1021/jm801340z
Homo sapiens SH-SY5Y IC50 17000.0 nM 10.1016/j.ejmech.2012.08.033
Homo sapiens SH-SY5Y IC50 17500.0 nM 10.1021/jm800109e
Homo sapiens SH-SY5Y IC50 21000.0 nM 10.1016/j.ejmech.2018.08.100
Homo sapiens SIG-M5 IC50 31683.34 nM 10.6019/CHEMBL1201861
Homo sapiens Signal recognition particle receptor subunit alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens SiHa IC50 2690.0 nM 10.1039/d2md00192f
Homo sapiens SIMA IC50 3053925.22 nM 10.6019/CHEMBL1201861
Homo sapiens SJSA-1 IC50 50104.81 nM 10.6019/CHEMBL1201861
Homo sapiens SK-LMS-1 IC50 1502931.78 nM 10.6019/CHEMBL1201861
Homo sapiens SKM-1 IC50 917722.45 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-1 IC50 1799649.14 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-2 GI50 15800.0 nM 10.1021/jm801340z
Homo sapiens SK-MEL-2 GI50 15848.93 nM 10.1021/jm801340z
Homo sapiens SK-MEL-2 GI50 17498.47 nM None
Homo sapiens SK-MEL-2 IC50 3199666.93 nM 10.6019/CHEMBL1201861
Homo sapiens SK-MEL-2 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens SK-MEL-2 TGI 39800.0 nM 10.1021/jm801340z
Homo sapiens SK-MEL-2 TGI 39810.72 nM 10.1021/jm801340z
Homo sapiens SK-MEL-28 GI50 nan None 10.1021/jm801340z
Homo sapiens SK-MEL-28 LC50 nan None 10.1021/jm801340z
Homo sapiens SK-MEL-28 TGI nan None 10.1021/jm801340z
Homo sapiens SK-MEL-5 GI50 10000.0 nM 10.1021/jm801340z
Homo sapiens SK-MEL-5 GI50 10715.19 nM None
Homo sapiens SK-MEL-5 LC50 79400.0 nM 10.1021/jm801340z
Homo sapiens SK-MEL-5 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens SK-MEL-5 TGI 31600.0 nM 10.1021/jm801340z
Homo sapiens SK-MEL-5 TGI 31622.78 nM 10.1021/jm801340z
Homo sapiens SK-MM-2 IC50 817603.91 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-DZ IC50 102847.78 nM 10.6019/CHEMBL1201861
Homo sapiens SK-NEP-1 IC50 283583.33 nM 10.6019/CHEMBL1201861
Homo sapiens SK-N-FI IC50 31753.5 nM 10.6019/CHEMBL1201861
Homo sapiens SK-OV-3 GI50 6309.57 nM 10.1021/jm801340z
Homo sapiens SK-OV-3 GI50 35700.0 nM 10.1021/jm100732t
Homo sapiens SK-OV-3 GI50 79400.0 nM 10.1021/jm801340z
Homo sapiens SK-OV-3 GI50 86297.85 nM None
Homo sapiens SK-OV-3 IC50 29000.0 nM 10.1016/j.ejmech.2018.08.100
Homo sapiens SK-OV-3 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens SK-OV-3 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens SK-PN-DW IC50 86238.96 nM 10.6019/CHEMBL1201861
Homo sapiens SK-UT-1 IC50 10349.96 nM 10.6019/CHEMBL1201861
Homo sapiens SN12C GI50 nan None 10.1021/jm801340z
Homo sapiens SN12C LC50 nan None 10.1021/jm801340z
Homo sapiens SN12C TGI nan None 10.1021/jm801340z
Homo sapiens SNB-19 GI50 12589.25 nM 10.1021/jm801340z
Homo sapiens SNB-19 GI50 nan None 10.1021/jm801340z
Homo sapiens SNB-19 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens SNB-19 LC50 nan None 10.1021/jm801340z
Homo sapiens SNB-19 TGI 31622.78 nM 10.1021/jm801340z
Homo sapiens SNB-19 TGI nan None 10.1021/jm801340z
Homo sapiens SNB-75 GI50 11324.0 nM None
Homo sapiens SNB-75 GI50 12600.0 nM 10.1021/jm801340z
Homo sapiens SNB-75 GI50 50118.72 nM 10.1021/jm801340z
Homo sapiens SNB-75 IC50 207660.6 nM 10.6019/CHEMBL1201861
Homo sapiens SNB-75 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens SNB-75 TGI 31600.0 nM 10.1021/jm801340z
Homo sapiens SNB-75 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens SNU1 IC50 31105.92 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-16 IC50 117136.98 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-5 IC50 182814.32 nM 10.6019/CHEMBL1201861
Homo sapiens SNU-638 IC50 9770.0 nM 10.1021/jm100080z
Homo sapiens SNU-C1 IC50 521320.49 nM 10.6019/CHEMBL1201861
Homo sapiens SR GI50 5010.0 nM 10.1021/jm801340z
Homo sapiens SR GI50 5011.87 nM 10.1021/jm801340z
Homo sapiens SR GI50 5395.11 nM None
Homo sapiens SR IC50 118844.75 nM 10.6019/CHEMBL1201861
Homo sapiens SR LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens SR TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens ST486 IC50 10350.98 nM 10.6019/CHEMBL1201861
Homo sapiens STE20-related kinase adapter protein alpha Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens STE20/SPS1-related proline-alanine-rich protein kinase Delta TM -0.51 C None
Homo sapiens Stem cell growth factor receptor Kd 10000.0 nM 10.1016/j.ejmech.2011.02.057
Homo sapiens Stem cell growth factor receptor Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Stem cell growth factor receptor Kd nan None 10.1038/nbt1068
Homo sapiens Structural maintenance of chromosomes protein 1A Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Structural maintenance of chromosomes protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens SU-DHL-1 IC50 162830.54 nM 10.6019/CHEMBL1201861
Homo sapiens SUP-T1 IC50 4498219.81 nM 10.6019/CHEMBL1201861
Homo sapiens Survival motor neuron protein Potency 8912.5 nM None
Homo sapiens Survival motor neuron protein Potency 12589.3 nM None
Homo sapiens Survival motor neuron protein Potency 17782.8 nM None
Homo sapiens SW-620 GI50 79400.0 nM 10.1021/jm801340z
Homo sapiens SW-620 GI50 79432.82 nM 10.1021/jm801340z
Homo sapiens SW-620 GI50 82413.81 nM None
Homo sapiens SW-620 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens SW-620 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens SW684 IC50 125195.19 nM 10.6019/CHEMBL1201861
Homo sapiens SW872 IC50 470292.57 nM 10.6019/CHEMBL1201861
Homo sapiens SW 954 IC50 290923.4 nM 10.6019/CHEMBL1201861
Homo sapiens SW 962 IC50 140782.48 nM 10.6019/CHEMBL1201861
Homo sapiens T47D GI50 16330.52 nM None
Homo sapiens T47D GI50 16800.0 nM 10.1021/jm801340z
Homo sapiens T47D GI50 39810.72 nM 10.1021/jm801340z
Homo sapiens T47D LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens T47D TGI 79400.0 nM 10.1021/jm801340z
Homo sapiens T47D TGI 79432.82 nM 10.1021/jm801340z
Homo sapiens TALL-1 IC50 69736.44 nM 10.6019/CHEMBL1201861
Homo sapiens TE-1 IC50 74627.49 nM 10.6019/CHEMBL1201861
Homo sapiens TE-10 IC50 34942.19 nM 10.6019/CHEMBL1201861
Homo sapiens TE-12 IC50 124527.68 nM 10.6019/CHEMBL1201861
Homo sapiens TE-15 IC50 878570.36 nM 10.6019/CHEMBL1201861
Homo sapiens TE-441-T IC50 36114.81 nM 10.6019/CHEMBL1201861
Homo sapiens TE-5 IC50 94354.13 nM 10.6019/CHEMBL1201861
Homo sapiens TE-6 IC50 36324.56 nM 10.6019/CHEMBL1201861
Homo sapiens TE-8 IC50 28907.96 nM 10.6019/CHEMBL1201861
Homo sapiens TE-9 IC50 28796.91 nM 10.6019/CHEMBL1201861
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens TGBC1TKB IC50 501318.19 nM 10.6019/CHEMBL1201861
Homo sapiens TGF-beta receptor type I Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens TGF-beta receptor type I Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TGF-beta receptor type II Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens TGF-beta receptor type II Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TGW IC50 17812.38 nM 10.6019/CHEMBL1201861
Homo sapiens THP-1 IC50 3237831.19 nM 10.6019/CHEMBL1201861
Homo sapiens Thyroid hormone receptor-associated protein 3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Thyroid hormone receptor beta-1 Potency 50118.7 nM None
Homo sapiens TK-10 GI50 5011.87 nM 10.1021/jm801340z
Homo sapiens TK-10 GI50 63100.0 nM 10.1021/jm801340z
Homo sapiens TK-10 GI50 64120.96 nM None
Homo sapiens TK-10 IC50 126376.05 nM 10.6019/CHEMBL1201861
Homo sapiens TK-10 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens TK-10 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens TP53-regulating kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TRAF2- and NCK-interacting kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens TRAF2- and NCK-interacting kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens TRAF2- and NCK-interacting kinase Kd nan None 10.1038/nbt1068
Homo sapiens TRAF2- and NCK-interacting kinase Thermal melting change 0.4 degrees C 10.1073/pnas.0708800104
Homo sapiens Transcription initiation factor TFIID subunit 1 Delta TM 0.07 C None
Homo sapiens Transcription intermediary factor 1-alpha Delta TM 0.4728 C None
Homo sapiens TUR IC50 2055521.78 nM 10.6019/CHEMBL1201861
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Delta TM -0.82 C None
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine- and threonine-specific cdc2-inhibitory kinase Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine kinase non-receptor protein 2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL Delta TM 0.1033 C None
Homo sapiens Tyrosine-protein kinase ABL Delta TM 1.01 C None
Homo sapiens Tyrosine-protein kinase ABL IC50 10000.0 nM 10.1016/j.bmcl.2016.05.004
Homo sapiens Tyrosine-protein kinase ABL IC50 100000.0 nM 10.1016/j.bmc.2015.02.026
Homo sapiens Tyrosine-protein kinase ABL IC50 100000.0 nM 10.1016/j.ejmech.2014.03.054
Homo sapiens Tyrosine-protein kinase ABL Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase ABL Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ABL2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase ABL2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase ABL2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BLK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BMX Delta TM 0.17 C None
Homo sapiens Tyrosine-protein kinase BMX Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BMX Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BRK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BRK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase BRK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase BTK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase BTK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase BTK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase CSK Activity 88.0 % 10.1042/bj20070797
Homo sapiens Tyrosine-protein kinase CSK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase CSK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase CSK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FER Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FER Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FER Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FES Delta TM 0.55 C None
Homo sapiens Tyrosine-protein kinase FES Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FES Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FGR Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FGR Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FGR Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FRK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FRK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FRK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase FYN Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase FYN Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase FYN Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase HCK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase HCK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase HCK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ITK/TSK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase JAK1 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase JAK1 Thermal melting change 0.1 degrees C 10.1073/pnas.0708800104
Homo sapiens Tyrosine-protein kinase JAK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase JAK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase JAK2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase JAK3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase LCK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase LCK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase LCK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase Lyn Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase Lyn Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase Lyn Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase receptor FLT3 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase receptor RET Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor RET Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase receptor Tie-1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase receptor UFO Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase SRC Delta TM 0.63 C None
Homo sapiens Tyrosine-protein kinase SRC Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase SRC Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase SRC Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase Srms Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase SYK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase SYK Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase SYK Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase TEC Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TEC Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase TIE-2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TIE-2 Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase TXK Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TYK2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase TYK2 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase YES Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosine-protein kinase YES Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Tyrosine-protein kinase YES Kd nan None 10.1038/nbt1068
Homo sapiens Tyrosine-protein kinase ZAP-70 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 22024.8 nM None
Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Potency 24712.2 nM None
Homo sapiens Tyrosyl-tRNA synthetase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens U-251 GI50 12589.25 nM 10.1021/jm801340z
Homo sapiens U-251 GI50 50100.0 nM 10.1021/jm801340z
Homo sapiens U-251 GI50 53826.98 nM None
Homo sapiens U-251 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens U-251 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens U-266 IC50 17930.0 nM 10.1158/0008-5472.can-05-0233
Homo sapiens U-266 IC50 1993318.27 nM 10.6019/CHEMBL1201861
Homo sapiens U2OS Growth Rate 0.0 None 10.6019/CHEMBL4689842
Homo sapiens U2OS Growth Rate 1.0 None 10.6019/CHEMBL4689842
Homo sapiens U2OS Inhibition nan % 10.1021/jm200064p
Homo sapiens U5 small nuclear ribonucleoprotein 200 kDa helicase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens U-698-M IC50 1257210.93 nM 10.6019/CHEMBL1201861
Homo sapiens U-87 MG IC50 187904.9 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-257 GI50 nan None 10.1021/jm801340z
Homo sapiens UACC-257 IC50 66314.86 nM 10.6019/CHEMBL1201861
Homo sapiens UACC-257 LC50 nan None 10.1021/jm801340z
Homo sapiens UACC-257 TGI nan None 10.1021/jm801340z
Homo sapiens UACC-62 GI50 7900.0 nM 10.1021/jm801340z
Homo sapiens UACC-62 GI50 7943.28 nM 10.1021/jm801340z
Homo sapiens UACC-62 GI50 8072.35 nM None
Homo sapiens UACC-62 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens UACC-62 TGI 31600.0 nM 10.1021/jm801340z
Homo sapiens UACC-62 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens UACC-812 IC50 711871.91 nM 10.6019/CHEMBL1201861
Homo sapiens UMP-CMP kinase Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized aarF domain-containing protein kinase 1 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Uncharacterized aarF domain-containing protein kinase 4 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Uncharacterized protein FLJ45252 Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens UO-31 GI50 12600.0 nM 10.1021/jm801340z
Homo sapiens UO-31 GI50 13645.83 nM None
Homo sapiens UO-31 GI50 63095.73 nM 10.1021/jm801340z
Homo sapiens UO-31 LC50 100000.0 nM 10.1021/jm801340z
Homo sapiens UO-31 TGI 63095.73 nM 10.1021/jm801340z
Homo sapiens UO-31 TGI 100000.0 nM 10.1021/jm801340z
Homo sapiens VA-ES-BJ IC50 187061.23 nM 10.6019/CHEMBL1201861
Homo sapiens Vascular endothelial growth factor receptor 1 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 2 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 2 Kd nan None 10.1038/nbt1068
Homo sapiens Vascular endothelial growth factor receptor 3 Kd 10000.0 nM 10.1038/nbt1358
Homo sapiens Vascular endothelial growth factor receptor 3 Kd nan None 10.1038/nbt1068
Homo sapiens Very long-chain specific acyl-CoA dehydrogenase, mitochondrial Kd 30000.0 nM 10.1126/science.aan4368
Homo sapiens Voltage-gated L-type calcium channel alpha-1C subunit IC50 23400.0 nM 10.1002/jat.2784
Homo sapiens Voltage-gated N-type calcium channel alpha-1B subunit EC50 27580.0 nM 10.1021/ml3002083
Homo sapiens WI-38 IC50 24120.0 nM 10.1016/j.bmc.2020.115633
Homo sapiens WSU-NHL IC50 2563674.86 nM 10.6019/CHEMBL1201861
Homo sapiens YT IC50 536409.57 nM 10.6019/CHEMBL1201861
Human alphaherpesvirus 3 Human alphaherpesvirus 3 IC50 14000.0 nM 10.1021/acs.jmedchem.0c01467
Human betaherpesvirus 5 Human betaherpesvirus 5 Inhibition 50.0 % 10.1021/acs.jmedchem.0c01467
Human immunodeficiency virus 1 Human immunodeficiency virus 1 EC50 360.0 nM 10.1021/acs.jmedchem.0c01467
Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 0.36 nM 10.1021/acs.jmedchem.0c01467
Influenza A virus Influenza A virus EC50 3300.0 nM 10.1021/acs.jmedchem.0c01467
Influenza A virus Influenza A virus IC50 3350.0 nM 10.1021/acs.jmedchem.0c01467
Influenza A virus Influenza A virus IC50 5990.0 nM 10.1021/acs.jmedchem.0c01467
Influenza A virus Influenza A virus IC50 7010.0 nM 10.1021/acs.jmedchem.0c01467
Klebsiella pneumoniae Klebsiella pneumoniae MIC 20000.0 nM 10.6019/CHEMBL4513161
Leishmania amazonensis Leishmania amazonensis Inhibition -20.3 % 10.1016/j.ejmech.2016.09.064
Leishmania amazonensis Leishmania amazonensis Inhibition -8.8 % 10.1016/j.ejmech.2016.09.064
Leishmania amazonensis Leishmania amazonensis Inhibition -3.8 % 10.1016/j.ejmech.2016.09.064
Mus musculus Casein kinase I alpha Activity nan None 10.1021/jm800109e
Mus musculus Dual specificity protein kinase CLK1 IC50 1200.0 nM 10.1016/j.ejmech.2018.08.100
Mus musculus Dual specificity protein kinase CLK1 IC50 4300.0 nM 10.1016/j.ejmech.2012.08.033
Mus musculus Dual specificity protein kinase CLK2 IC50 710.0 nM 10.1016/j.ejmech.2018.08.100
Mus musculus Dual specificity protein kinase CLK3 IC50 10000.0 nM 10.1016/j.ejmech.2018.08.100
Mus musculus Dual specificity protein kinase CLK4 IC50 620.0 nM 10.1016/j.ejmech.2018.08.100
Mus musculus Dual-specificity tyrosine-phosphorylation regulated kinase 1A IC50 5000.0 nM 10.1016/j.bmcl.2006.04.042
Mus musculus Dual-specificity tyrosine-phosphorylation regulated kinase 1A Inhibition 63.0 % 10.1016/j.bmcl.2006.04.042
Mus musculus Liver Activity 67.0 % 10.1016/j.bmc.2011.08.051
Mus musculus Mus musculus AUC 18928.16 ng.hr.mL-1 10.1016/j.bmc.2011.08.051
Mus musculus Mus musculus CL 0.051 L/hr 10.1016/j.bmc.2011.08.051
Mus musculus Mus musculus Cmax 93700.0 nM 10.1016/j.bmc.2011.08.051
Mus musculus Mus musculus T1/2 1.4 hr 10.1016/j.bmc.2011.08.051
Mus musculus Mus musculus Vd 0.073 l 10.1016/j.bmc.2011.08.051
Mus musculus Serine/threonine-protein kinase MST2 Kd nan None 10.1038/nbt1068
Mus musculus Tyrosine-protein kinase LCK Activity 76.0 % 10.1042/bj20070797
Mus musculus ULK3 kinase Kd nan None 10.1038/nbt1068
Plasmodium falciparum Plasmodium falciparum IC50 3981.07 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 6309.57 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 10000.0 nM 10.1038/nchembio.215
Plasmodium falciparum Plasmodium falciparum IC50 25000.0 nM 10.1021/acs.jmedchem.2c00996
Plasmodium falciparum Plasmodium falciparum IC50 28000.0 nM 10.1016/j.bmc.2010.01.068
Plasmodium falciparum Plasmodium falciparum IC50 28000.0 nM 10.1021/jm0300983
Plasmodium falciparum Plasmodium falciparum IC50 33000.0 nM 10.1021/jm0300983
Plasmodium falciparum Plasmodium falciparum Potency 1041.8 nM None
Plasmodium falciparum Plasmodium falciparum Potency 4653.5 nM None
Plasmodium falciparum Protein kinase Pfmrk IC50 1000000.0 nM 10.1021/jm0300983
Pseudomonas aeruginosa Pseudomonas aeruginosa MIC 20000.0 nM 10.6019/CHEMBL4513161
Rattus norvegicus C6 Activity 100.0 % 10.1016/j.ejmech.2019.111602
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A IC50 11000.0 nM 10.1016/j.ejmech.2012.09.001
Rattus norvegicus Inositol monophosphatase 1 Potency 2818.4 nM None
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Potency 37.7 nM None
Rattus norvegicus Tubulin alpha-1 chain Kd 10000.0 nM 10.1038/nbt1358
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 4.845 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 11.33 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -5.01 % 10.21203/rs.3.rs-23951/v1
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 1.28 % 10.6019/CHEMBL4495565
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition 2.17 % 10.6019/CHEMBL4495565
Staphylococcus aureus Staphylococcus aureus MIC 20000.0 nM 10.6019/CHEMBL4513161
Sus scrofa Glycogen synthase kinase-3 IC50 10000.0 nM 10.1016/j.ejmech.2018.08.100
Sus scrofa Glycogen synthase kinase-3 IC50 10000.0 nM 10.1021/jm800109e
Sus scrofa Glycogen synthase kinase-3 IC50 60000.0 nM 10.1016/j.ejmech.2014.06.063
Sus scrofa Glycogen synthase kinase-3 IC50 100000.0 nM 10.1021/np070341r
Zika virus Zika virus IC50 24.0 nM 10.1021/acs.jmedchem.0c01467
None ADMET CL 107.15 uL.min-1.(10^6cells)-1 10.6019/CHEMBL3301361
None ADMET CL 123.03 mL.min-1.g-1 10.6019/CHEMBL3301361
None ADMET Fu 0.048 None 10.1021/acs.jmedchem.0c02011
None ADMET Fu 0.092 None 10.1021/acs.jmedchem.0c02011
None ADMET IC50 20480.0 nM 10.1016/j.bmcl.2012.08.117
None ADMET IC50 25000.0 nM 10.1016/j.bmc.2009.07.051
None ADMET IC50 25000.0 nM 10.1016/j.ejmech.2011.08.048
None ADMET IC50 25000.0 nM 10.1016/j.ejmech.2012.09.001
None ADMET IC50 25000.0 nM 10.1073/pnas.0708800104
None ADMET K(p,uu,brain) 0.205 None 10.1021/acs.jmedchem.0c02011
None ADMET PPB 92.8 % 10.6019/CHEMBL3301361
None ADMET Ratio 1.259 None 10.1021/acs.jmedchem.0c02011
None ADMET Ratio AUC 0.3 None 10.1021/acs.jmedchem.6b00618
None BC1 cell line IC50 19119.83 nM 10.6019/CHEMBL1201861
None COLO1 IC50 nan ug.mL-1 10.1016/s0960-894x(00)00014-7
None Erythrocyte HC10 20.0 uM 10.6019/CHEMBL4513161
None Fibroblast IC50 20000.0 nM 10.1016/j.bmc.2017.01.049
None Hepatotoxicity Hepatotoxicity nan None 10.1021/tx900326k
None Neutrophil Activity 0.033 % 10.1016/j.bmc.2013.01.009
None Neutrophil Activity 0.386 % 10.1016/j.bmc.2013.01.009
None Neutrophil Activity 6.98 % 10.1016/j.bmc.2013.01.009
None Neutrophil Activity 92.6 % 10.1016/j.bmc.2013.01.009
None Neutrophil Activity nan None 10.1016/j.bmc.2013.01.009
None NON-PROTEIN TARGET Activity 50.0 % 10.1158/0008-5472.can-05-0233
None NON-PROTEIN TARGET Activity 73.0 % 10.1021/jm801340z
None NON-PROTEIN TARGET Activity nan None 10.1016/j.bmcl.2011.05.019
None NON-PROTEIN TARGET Activity nan None 10.1158/0008-5472.can-05-0233
None NON-PROTEIN TARGET GI50 12800.0 nM 10.1021/jm801340z
None NON-PROTEIN TARGET GI50 19300.0 nM 10.1021/jm801340z
None NON-PROTEIN TARGET GI50 19900.0 nM 10.1021/jm801340z
None NON-PROTEIN TARGET GI50 19952.62 nM 10.1021/jm801340z
None NON-PROTEIN TARGET GI50 20000.0 nM 10.1016/j.bmcl.2009.10.011
None NON-PROTEIN TARGET GI50 20000.0 nM 10.1016/j.bmcl.2009.10.025
None NON-PROTEIN TARGET GI50 25100.0 nM 10.1021/jm801340z
None NON-PROTEIN TARGET GI50 25118.86 nM 10.1021/jm801340z
None NON-PROTEIN TARGET IC50 2000.0 nM 10.1016/j.ejmech.2016.02.072
None NON-PROTEIN TARGET IC50 3000.0 nM 10.1016/j.ejmech.2016.02.072
None NON-PROTEIN TARGET IC50 5000.0 nM 10.1016/j.ejmech.2015.06.046
None NON-PROTEIN TARGET IC50 5000.0 nM 10.1016/j.ejmech.2016.02.072
None NON-PROTEIN TARGET IC50 6000.0 nM 10.1016/j.bmc.2009.07.051
None NON-PROTEIN TARGET IC50 7600.0 nM 10.1016/j.ejmech.2015.04.062
None NON-PROTEIN TARGET IC50 8840.0 nM 10.1158/0008-5472.can-05-0233
None NON-PROTEIN TARGET IC50 9000.0 nM 10.1016/j.ejmech.2015.04.062
None NON-PROTEIN TARGET IC50 14420.0 nM 10.1016/j.ejmech.2016.01.011
None NON-PROTEIN TARGET IC50 17400.0 nM 10.1016/j.bmcl.2012.10.141
None NON-PROTEIN TARGET IC50 17800.0 nM 10.1021/jm100080z
None NON-PROTEIN TARGET IC50 19500.0 nM 10.1158/0008-5472.can-05-0233
None NON-PROTEIN TARGET IC50 20000.0 nM 10.1016/j.ejmech.2011.08.048
None NON-PROTEIN TARGET IC50 20800.0 nM 10.1016/j.ejmech.2015.12.023
None NON-PROTEIN TARGET IC50 22400.0 nM 10.1016/j.ejmech.2016.01.011
None NON-PROTEIN TARGET IC50 25000.0 nM 10.1073/pnas.0708800104
None NON-PROTEIN TARGET IC50 50000.0 nM 10.1073/pnas.0708800104
None NON-PROTEIN TARGET LC50 79400.0 nM 10.1021/jm801340z
None NON-PROTEIN TARGET LC50 99400.0 nM 10.1021/jm801340z
None NON-PROTEIN TARGET LC50 100000.0 nM 10.1021/jm801340z
None NON-PROTEIN TARGET Potency 3162.3 nM None
None NON-PROTEIN TARGET Potency 3981.1 nM None
None NON-PROTEIN TARGET Potency 5011.9 nM None
None NON-PROTEIN TARGET Potency 5623.4 nM None
None NON-PROTEIN TARGET Potency 6309.6 nM None
None NON-PROTEIN TARGET Potency 10000.0 nM None
None NON-PROTEIN TARGET TGI 12600.0 nM 10.1021/jm801340z
None NON-PROTEIN TARGET TGI 78300.0 nM 10.1021/jm801340z
None NON-PROTEIN TARGET TGI 100000.0 nM 10.1021/jm801340z
None No relevant target LogD7.4 3.63 None 10.6019/CHEMBL3301361
None No relevant target Solubility 74100.0 nM 10.6019/CHEMBL3301361
None Unchecked Activity 57.1 % 10.1016/j.bmcl.2015.04.030
None Unchecked Activity 91.0 % 10.1042/bj20070797
None Unchecked Activity 93.0 % 10.1042/bj20070797
None Unchecked CC50 22000.0 nM 10.1021/acs.jmedchem.0c01467
None Unchecked GI50 1485.0 nM 10.1021/acs.jmedchem.1c02184
None Unchecked GI50 3067.0 nM 10.1021/acs.jmedchem.1c02184
None Unchecked GI50 23600.0 nM 10.1016/j.ejmech.2016.09.093
None Unchecked IC50 0.16 nM 10.1021/acs.jmedchem.1c02064
None Unchecked IC50 0.65 nM 10.1021/acs.jmedchem.1c02064
None Unchecked IC50 100.0 nM 10.1021/acs.jmedchem.1c02064
None Unchecked IC50 160.0 nM 10.1021/np070341r
None Unchecked IC50 200.0 nM 10.1021/jm800109e
None Unchecked IC50 200.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 310.0 nM 10.1016/j.ejmech.2018.08.100
None Unchecked IC50 330.0 nM 10.1016/j.ejmech.2012.08.033
None Unchecked IC50 330.0 nM 10.1016/j.ejmech.2014.06.063
None Unchecked IC50 330.0 nM 10.1021/jm801340z
None Unchecked IC50 350.0 nM 10.1021/jm800109e
None Unchecked IC50 450.0 nM 10.1021/jm0704090
None Unchecked IC50 450.0 nM 10.1021/np070341r
None Unchecked IC50 650.0 nM 10.1021/acs.jmedchem.1c02190
None Unchecked IC50 650.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 700.0 nM 10.1073/pnas.0708800104
None Unchecked IC50 730.0 nM 10.1016/j.ejmech.2018.08.100
None Unchecked IC50 810.0 nM 10.1158/0008-5472.can-05-0233
None Unchecked IC50 2300.0 nM 10.1016/j.bmcl.2012.10.141
None Unchecked IC50 2300.0 nM 10.1021/jm800109e
None Unchecked IC50 14801.0 nM 10.1016/j.bmcl.2018.10.020
None Unchecked IC50 15000.0 nM 10.1016/j.ejmech.2011.09.041
None Unchecked IC50 15000.0 nM 10.1021/acs.jnatprod.5b01073
None Unchecked IC50 18000.0 nM 10.1021/acs.jnatprod.5b01073
None Unchecked IC50 20000.0 nM 10.1021/np070341r
None Unchecked IC50 21000.0 nM 10.1016/j.ejmech.2018.08.100
None Unchecked IC50 21700.0 nM 10.1016/j.bmcl.2018.10.020
None Unchecked IC50 32000.0 nM 10.1016/j.ejmech.2018.08.100
None Unchecked IC50 50000.0 nM 10.1016/j.bmc.2011.08.051
None Unchecked IC50 1000000.0 nM 10.1016/j.bmcl.2004.01.050
None Unchecked IC50 1000000.0 nM 10.1021/jm011002c
None Unchecked Inhibition 38.6 % 10.1016/j.bmcl.2015.04.030
None Unchecked Inhibition nan % 10.1038/nchembio873
None Unchecked Kd 30000.0 nM 10.1126/science.aan4368
None Unchecked LC50 100000.0 nM 10.1016/j.ejmech.2016.09.093
None Unchecked Potency 10000.0 nM None
None Unchecked Potency 22387.2 nM None
None Unchecked Potency 35481.3 nM None
None Unchecked Ratio IC50 1.55 None 10.1016/j.bmc.2020.115633
None Unchecked Ratio IC50 5.8 None 10.1016/j.bmc.2017.01.049
None Unchecked Ratio IC50 5.9 None 10.1016/j.bmc.2017.01.049
None Unchecked Ratio IC50 6.4 None 10.1016/j.bmc.2017.01.049
None Unchecked Ratio IC50 7.6 None 10.1016/j.bmc.2017.01.049
None Unchecked Ratio IC50 9.7 None 10.1016/j.bmc.2017.01.049
None Unchecked Ratio IC50 12.2 None 10.1016/j.bmc.2017.01.049
None Unchecked Ratio IC50 60.0 None 10.1016/j.bmc.2011.08.051
None Unchecked Ratio IC50 80.0 None 10.1016/j.bmc.2011.08.051
None Unchecked Ratio IC50 108.6 None 10.1016/j.bmc.2017.01.049
None Unchecked TGI 84800.0 nM 10.1016/j.ejmech.2016.09.093

Metabolism Information