lucidamine B
AlkaPlorer ID: AK140776
Synonym: '(-)-Lucidamine B', 'Lucidamine B'
IUPAC Name: 1-[(6S)-2,3-dihydroxy-7,8-dimethoxy-5-methyl-1,4-bis(2-methylbut-3-en-2-yl)-6H-benzo[c]phenanthridin-6-yl]propan-2-one
Structure
SMILES: C=CC(C)(C)C1=C(O)C(O)=C(C(C)(C)C=C)C2=C3C(=CC=C12)C1=CC=C(OC)C(OC)=C1[C@H](CC(C)=O)N3C
InChI: InChI=1S/C33H39NO5/c1-11-32(4,5)26-21-14-13-20-19-15-16-23(38-9)31(39-10)24(19)22(17-18(3)35)34(8)28(20)25(21)27(30(37)29(26)36)33(6,7)12-2/h11-16,22,36-37H,1-2,17H2,3-10H3/t22-/m0/s1
InChIKey: JBKDWQUWYFBOCS-QFIPXVFZSA-N
Reference
Trypanocidal and Antileishmanial Dihydrochelerythrine Derivatives from <i>Garcinia lucida</i>
PubChem CID: 23656475
LOTUS: LTS0135267
NPASS: NPC471489
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Garcinia lucida | Garcinia | Clusiaceae | Malpighiales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 529.6770000000002
TPSA？: 79.23
MolLogP？: 7.33240000000001
Number of H-Donors: 2
Number of H-Acceptors: 6
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Chlorocebus sabaeus | Vero | IC50 | 17500.0 | nM | 10.1021/np0702281 |
| Leishmania donovani | Leishmania donovani | Activity | nan | None | 10.1021/np0702281 |
| Leishmania donovani | Leishmania donovani | IC50 | 6800.0 | nM | 10.1021/np0702281 |
| Leishmania donovani | Leishmania donovani | Inhibition | 14.0 | % | 10.1021/np0702281 |
| Leishmania donovani | Leishmania donovani | Inhibition | 48.0 | % | 10.1021/np0702281 |
| Leishmania donovani | Leishmania donovani | Inhibition | 64.0 | % | 10.1021/np0702281 |
| Mus musculus | RAW | Activity | nan | None | 10.1021/np0702281 |
| Trypanosoma brucei brucei | Trypanosoma brucei brucei | IC50 | 4100.0 | nM | 10.1021/np0702281 |