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Fascaplysin

AlkaPlorer ID: AK141084

Synonym: None

IUPAC Name: 3,13-diazapentacyclo[11.7.0.02,10.04,9.014,19]icosa-1,3,5,7,9,11,14,16,18-nonaen-20-one

Structure

SMILES: O=C1C2=CC=CC=C2N2C=CC3=C4C=CC=CC4=NC3=C12

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InChI: InChI=1S/C18H10N2O/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20/h1-10H

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InChIKey: WYQIPCUPNMRAKP-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Hyrtios erectus Hyrtios Thorectidae Dictyoceratida Demospongiae Porifera Metazoa Eukaryota

Properties Information

Molecule Weight: 270.29100000000005

TPSA？: 34.89

MolLogP？: 3.6747000000000014

Number of H-Donors: 0

Number of H-Acceptors: 3

RingCount: 5

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Electrophorus electricus Acetylcholinesterase IC50 1490.0 nM 10.1039/C2MD20076G
Electrophorus electricus Acetylcholinesterase Inhibition 86.0 % 10.1039/C2MD20076G
Electrophorus electricus Acetylcholinesterase Ki 2280.0 nM 10.1039/C2MD20076G
Equus caballus Cholinesterase IC50 90470.0 nM 10.1039/C2MD20076G
Equus caballus Cholinesterase Ki 48490.0 nM 10.1039/C2MD20076G
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens 3-phosphoinositide dependent protein kinase-1 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens A549 IC50 0.38 ug.mL-1 10.1016/j.ejmech.2021.113688
Homo sapiens Acetylcholinesterase IC50 1500.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens Activin receptor type-1B Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Activin receptor type-1B Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens ALK tyrosine kinase receptor Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase, AMPK Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 1 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens BR serine/threonine-protein kinase 2 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Butyrylcholinesterase IC50 90000.0 nM 10.1021/acs.jmedchem.0c01887
Homo sapiens CaM kinase I alpha Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I alpha Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens CaM kinase I delta Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II beta Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II delta Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens CaM kinase II gamma Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens CaM kinase IV Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens cAMP-dependent protein kinase alpha-catalytic subunit Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I delta Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 1 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I gamma 2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Casein kinase II alpha (prime) Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Casein kinase I isoform gamma-3 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens CDK2/Cyclin A2 IC50 500000.0 nM 10.1039/C2MD20076G
Homo sapiens CDK3/cyclin E Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens CDK3/cyclin E Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens CDK4/Cyclin D3 IC50 100000.0 nM 10.1039/C2MD20076G
Homo sapiens CDK6/cyclin D1 IC50 3400.0 nM 10.1039/C2MD20076G
Homo sapiens CDK6/cyclin D2 IC50 50000.0 nM 10.1039/C2MD20076G
Homo sapiens CDK6/cyclin D3 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens CDK6/cyclin D3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens CDK9/cyclin T1 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens cGMP-dependent protein kinase 1 beta Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 2 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens c-Jun N-terminal kinase 3 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 IC50 100000.0 nM 10.1039/C2MD20076G
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin A Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 2/cyclin E1 IC50 50000.0 nM 10.1039/C2MD20076G
Homo sapiens Cyclin-dependent kinase 4/cyclin D1 IC50 350.0 nM 10.1039/C2MD20076G
Homo sapiens Cyclin-dependent kinase 4/cyclin D2 IC50 100000.0 nM 10.1039/C2MD20076G
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 IC50 20000.0 nM 10.1039/C2MD20076G
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 5/CDK5 activator 1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Cyclin-dependent kinase 7/ cyclin H Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Death-associated protein kinase 3 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Discoidin domain-containing receptor 2 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 1 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Dual specificity mitogen-activated protein kinase kinase 7 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Dual specificity protein kinase CLK3 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Dual-specificity tyrosine-phosphorylation regulated kinase 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 3 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 4 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 5 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 7 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-A receptor 8 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 2 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 3 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Ephrin type-B receptor 4 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 0.0 % 10.1042/bj20121418
Homo sapiens Epidermal growth factor receptor erbB1 Residual Activity 9.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 1 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 3 Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Fibroblast growth factor receptor 4 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Focal adhesion kinase 1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 alpha Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Glycogen synthase kinase-3 beta Residual Activity 120.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 5 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 6 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens G protein-coupled receptor kinase 7 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Hepatocyte growth factor receptor Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Homeodomain-interacting protein kinase 3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase alpha subunit Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Inhibitor of nuclear factor kappa B kinase beta subunit Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 59.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Insulin-like growth factor I receptor Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Insulin receptor-related protein Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 1 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Interleukin-1 receptor-associated kinase 4 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens LIM domain kinase 1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens LNCaP IC50 540.0 nM 10.1016/j.bmcl.2014.05.104
Homo sapiens LNCaP Ratio IC50 0.63 None 10.1016/j.bmcl.2014.05.104
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Macrophage colony stimulating factor receptor Residual Activity 68.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Macrophage-stimulating protein receptor Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Malme-3M EC50 0.03 ug.mL-1 10.1016/j.bmcl.2014.05.104
Homo sapiens Malme-3M IC50 0.03 ug.mL-1 10.1016/j.ejmech.2021.113688
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 3 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens MAP kinase-activated protein kinase 5 Residual Activity 124.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens MAP kinase ERK2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 alpha Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 beta Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 delta Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens MAP kinase p38 gamma Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 42.0 % 10.1042/bj20121418
Homo sapiens MAP kinase signal-integrating kinase 2 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens MAP/microtubule affinity-regulating kinase 2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Maternal embryonic leucine zipper kinase Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens MCF7 EC50 0.14 ug.mL-1 10.1016/j.bmcl.2014.05.104
Homo sapiens MCF7 IC50 0.14 ug.mL-1 10.1016/j.ejmech.2021.113688
Homo sapiens Misshapen-like kinase 1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Misshapen-like kinase 1 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase 9 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 2 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Muscle, skeletal receptor tyrosine protein kinase Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Myosin light chain kinase, smooth muscle Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Myotonin-protein kinase Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 47.0 % 10.1042/bj20121418
Homo sapiens Nerve growth factor receptor Trk-A Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Neurotrophic tyrosine kinase receptor type 2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens NFF IC50 339.0 nM 10.1016/j.bmcl.2014.05.104
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens NUAK family SNF1-like kinase 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens OVCAR-3 IC50 0.16 ug.mL-1 10.1016/j.ejmech.2021.113688
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 119.0 % 10.1042/bj20121418
Homo sapiens PAS domain-containing serine/threonine-protein kinase Residual Activity 147.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Phosphorylase kinase gamma subunit 2 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor alpha Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Platelet-derived growth factor receptor beta Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C alpha Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C beta Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C delta Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C epsilon Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C eta Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C gamma Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C iota Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C mu Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C theta Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Protein kinase C zeta Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Protein kinase N2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Protein tyrosine kinase 2 beta Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase MER Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Receptor protein-tyrosine kinase erbB-4 Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 115.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 1 Residual Activity 126.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Rho-associated protein kinase 2 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 54.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase 1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 1 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 50.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 3 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 4 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 5 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Ribosomal protein S6 kinase alpha 6 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 10 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 11 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 17A Residual Activity 114.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 24 Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase 33 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase AKT3 Residual Activity 112.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-A Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-B Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 72.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Aurora-C Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Chk2 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase D2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase DCLK2 Residual Activity 105.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase EEF2K Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase haspin Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MARK1 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK-A Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MRCK beta Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST1 Residual Activity 108.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 100.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase MST2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 103.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase mTOR Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 44.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek11 Residual Activity 48.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Nek3 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK6 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase NEK7 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 70.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine protein kinase NLK Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 2 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 3 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK 4 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 84.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK6 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 82.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PAK7 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM1 Residual Activity 110.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 130.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM2 Residual Activity 144.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PIM3 Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK1 Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PLK3 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase PRKX Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RAF Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase RIPK2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk1 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk2 Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase Sgk3 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SIK1 Residual Activity 116.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK1 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 99.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase SRPK3 Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO1 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO2 Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TAO3 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 53.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase TBK1 Residual Activity 58.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase tousled-like 2 Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase ULK3 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase VRK2 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Serine/threonine-protein kinase WNK3 Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Stem cell growth factor receptor Residual Activity 106.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 1 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Testis-specific serine/threonine-protein kinase 2 Residual Activity 98.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens TGF-beta receptor type I Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 55.0 % 10.1042/bj20121418
Homo sapiens Tyrosine kinase non-receptor protein 2 Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ABL2 Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BLK Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 71.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BMX Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BRK Residual Activity 97.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase BTK Residual Activity 94.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase CSK Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FER Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FES Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FGR Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 92.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FRK Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 76.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase FYN Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 57.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 80.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 83.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase HCK Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ITK/TSK Residual Activity 96.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 95.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK2 Residual Activity 101.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 102.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase JAK3 Residual Activity 109.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 69.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 81.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase LCK Residual Activity 85.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 65.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase Lyn Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 52.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor FLT3 Residual Activity 87.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor RET Residual Activity 89.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 104.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor TYRO3 Residual Activity 107.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 62.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase receptor UFO Residual Activity 73.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 91.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SRC Residual Activity 111.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase SYK Residual Activity 93.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 74.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TEC Residual Activity 77.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TIE-2 Residual Activity 90.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase TXK Residual Activity 75.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 86.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase YES Residual Activity 113.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 128.0 % 10.1042/bj20121418
Homo sapiens Tyrosine-protein kinase ZAP-70 Residual Activity 132.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 67.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 1 Residual Activity 79.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 78.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 2 Residual Activity 88.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 25.0 % 10.1042/bj20121418
Homo sapiens Vascular endothelial growth factor receptor 3 Residual Activity 76.0 % 10.1042/bj20121418
None NON-PROTEIN TARGET EC50 0.16 ug.mL-1 10.1016/j.bmcl.2014.05.104
None Unchecked AC50 358.0 nM None
None Unchecked Ratio IC50 60.7 None 10.1039/C2MD20076G

Metabolism Information