| Giardia intestinalis |
Putative fructose-1,6-bisphosphate aldolase |
Potency |
15811.4 |
nM |
None |
| Homo sapiens |
3-phosphoinositide dependent protein kinase-1 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Actin-related protein 2 |
Activity |
20.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Activin receptor type-1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Activin receptor type-1B |
Activity |
5.45 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Activin receptor type-1B |
Residual Activity |
-4.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Activin receptor type-1B |
Residual Activity |
-3.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Adaptor-associated kinase |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
ALK tyrosine kinase receptor |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
ALK tyrosine kinase receptor |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
ALK tyrosine kinase receptor |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
AMP-activated protein kinase, alpha-1 subunit |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
AMP-activated protein kinase, alpha-2 subunit |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
AMP-activated protein kinase, AMPK |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
AMP-activated protein kinase, AMPK |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
BMP-2-inducible protein kinase |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Bone morphogenetic protein receptor type-1A |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
BR serine/threonine-protein kinase 1 |
Residual Activity |
58.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
BR serine/threonine-protein kinase 1 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
BR serine/threonine-protein kinase 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
BR serine/threonine-protein kinase 2 |
Residual Activity |
113.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
BR serine/threonine-protein kinase 2 |
Residual Activity |
120.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Caco-2 |
permeability |
76.0 |
% |
10.1021/jm701199p |
| Homo sapiens |
CaM kinase I alpha |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase I alpha |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I alpha |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I delta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase I delta |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I delta |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase I gamma |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase II alpha |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase II beta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase II beta |
Residual Activity |
68.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II beta |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II delta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase II delta |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II delta |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II gamma |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
CaM kinase II gamma |
Residual Activity |
69.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase II gamma |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase IV |
Residual Activity |
78.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM kinase IV |
Residual Activity |
139.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CaM-kinase kinase alpha |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
CaM-kinase kinase beta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
cAMP-dependent protein kinase alpha-catalytic subunit |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cAMP-dependent protein kinase alpha-catalytic subunit |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I alpha |
Activity |
10.5 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Casein kinase I delta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Casein kinase I delta |
Residual Activity |
2.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I delta |
Residual Activity |
25.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I epsilon |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Casein kinase I gamma 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Casein kinase I gamma 1 |
Residual Activity |
47.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I gamma 1 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I gamma 2 |
Residual Activity |
53.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I gamma 2 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase II |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase II |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase II alpha |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Casein kinase II alpha (prime) |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Casein kinase II alpha (prime) |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase II alpha (prime) |
Residual Activity |
120.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I isoform gamma-3 |
Residual Activity |
50.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Casein kinase I isoform gamma-3 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK3/cyclin E |
Residual Activity |
79.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK3/cyclin E |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK6/cyclin D3 |
Residual Activity |
68.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK6/cyclin D3 |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK9/cyclin T1 |
Residual Activity |
67.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
CDK9/cyclin T1 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cGMP-dependent protein kinase 1 beta |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cGMP-dependent protein kinase 1 beta |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cGMP-dependent protein kinase 1 beta |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
cGMP-dependent protein kinase 1 beta |
Residual Activity |
116.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
c-Jun N-terminal kinase 1 |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 1 |
Residual Activity |
117.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
c-Jun N-terminal kinase 2 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 2 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 3 |
Activity |
9.2 |
% |
10.1021/jm8011036 |
| Homo sapiens |
c-Jun N-terminal kinase 3 |
Residual Activity |
52.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
c-Jun N-terminal kinase 3 |
Residual Activity |
79.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 1/cyclin B1 |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 1/cyclin B1 |
Residual Activity |
115.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Cyclin-dependent kinase 2/cyclin A |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 2/cyclin A |
Residual Activity |
117.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 2/cyclin E |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 2/cyclin E |
Residual Activity |
113.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 5 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
63.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
74.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 5/CDK5 activator 1 |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 7/ cyclin H |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cyclin-dependent kinase 7/ cyclin H |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Cytochrome P450 3A4 |
IC50 |
10000.0 |
nM |
None |
| Homo sapiens |
Death-associated protein kinase 1 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 1 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Death-associated protein kinase 2 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 2 |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Death-associated protein kinase 3 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Death-associated protein kinase 3 |
Residual Activity |
113.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Discoidin domain-containing receptor 2 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Discoidin domain-containing receptor 2 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 1 |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 1 |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 6 |
Residual Activity |
48.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 6 |
Residual Activity |
75.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 7 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity mitogen-activated protein kinase kinase 7 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Dual specificity protein kinase CLK2 |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK2 |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Dual specificity protein kinase CLK3 |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK3 |
Residual Activity |
132.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificity protein kinase CLK4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Dual specificity protein kinase TTK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Dual specificity testis-specific protein kinase 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Dual specificty protein kinase CLK1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 1 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 2 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 2 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 3 |
Residual Activity |
78.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 3 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 4 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 4 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 5 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 5 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 5 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 6 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 7 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 7 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 7 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 8 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-A receptor 8 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-A receptor 8 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-B receptor 1 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 1 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-B receptor 2 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 2 |
Residual Activity |
115.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-B receptor 3 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 3 |
Residual Activity |
137.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ephrin type-B receptor 4 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ephrin type-B receptor 4 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Epidermal growth factor receptor erbB1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Epidermal growth factor receptor erbB1 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Epidermal growth factor receptor erbB1 |
Residual Activity |
119.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Eukaryotic translation initiation factor 2-alpha kinase 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Fibroblast growth factor receptor 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Fibroblast growth factor receptor 1 |
Residual Activity |
72.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 1 |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Fibroblast growth factor receptor 2 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 2 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Fibroblast growth factor receptor 3 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 3 |
Residual Activity |
118.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Fibroblast growth factor receptor 4 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Fibroblast growth factor receptor 4 |
Residual Activity |
121.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Focal adhesion kinase 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Focal adhesion kinase 1 |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Focal adhesion kinase 1 |
Residual Activity |
120.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Glycogen synthase kinase-3 alpha |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Glycogen synthase kinase-3 alpha |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Glycogen synthase kinase-3 alpha |
Residual Activity |
135.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Glycogen synthase kinase-3 beta |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Glycogen synthase kinase-3 beta |
Residual Activity |
113.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 5 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 6 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 6 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 7 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
G protein-coupled receptor kinase 7 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Hepatocyte growth factor receptor |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Hepatocyte growth factor receptor |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Hepatocyte growth factor receptor |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
HepG2 |
IC50 |
60.0 |
nM |
10.1016/j.bmcl.2003.09.028 |
| Homo sapiens |
Histone deacetylase 6 |
Inhibition |
-6.98 |
% |
10.6019/CHEMBL4808148 |
| Homo sapiens |
Histone deacetylase 6 |
Inhibition |
-5.98 |
% |
10.6019/CHEMBL4808148 |
| Homo sapiens |
Homeodomain-interacting protein kinase 1 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 1 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 2 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 2 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 3 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Homeodomain-interacting protein kinase 3 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase alpha subunit |
Residual Activity |
117.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase alpha subunit |
Residual Activity |
118.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase beta subunit |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Inhibitor of nuclear factor kappa B kinase beta subunit |
Residual Activity |
115.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Residual Activity |
131.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin-like growth factor I receptor |
Residual Activity |
133.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Insulin receptor |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor-related protein |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Insulin receptor-related protein |
Residual Activity |
79.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Insulin receptor-related protein |
Residual Activity |
132.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Interleukin-1 receptor-associated kinase 1 |
Residual Activity |
73.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Interleukin-1 receptor-associated kinase 1 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Interleukin-1 receptor-associated kinase 4 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Interleukin-1 receptor-associated kinase 4 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Leukocyte tyrosine kinase receptor |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
LIM domain kinase 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
LIM domain kinase 1 |
Residual Activity |
74.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
LIM domain kinase 1 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
LIM domain kinase 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Liver microsomes |
Stability |
22.0 |
% |
10.1021/jm701199p |
| Homo sapiens |
Lysyl-tRNA synthetase |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Macrophage colony stimulating factor receptor |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Macrophage colony stimulating factor receptor |
Residual Activity |
71.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Macrophage colony stimulating factor receptor |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Macrophage-stimulating protein receptor |
Residual Activity |
78.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Macrophage-stimulating protein receptor |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 2 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 2 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 3 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 3 |
Residual Activity |
125.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 5 |
Residual Activity |
73.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase-activated protein kinase 5 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase ERK1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
MAP kinase ERK1 |
Residual Activity |
83.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase ERK1 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase ERK2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
MAP kinase ERK2 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase ERK2 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 alpha |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
MAP kinase p38 alpha |
IC50 |
740.0 |
nM |
10.1021/jm0205705 |
| Homo sapiens |
MAP kinase p38 alpha |
IC50 |
51000.0 |
nM |
10.1016/j.bmcl.2004.04.065 |
| Homo sapiens |
MAP kinase p38 alpha |
Residual Activity |
15.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 alpha |
Residual Activity |
49.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 beta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
MAP kinase p38 beta |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 beta |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 delta |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 delta |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 gamma |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
MAP kinase p38 gamma |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase p38 gamma |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase signal-integrating kinase 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
MAP kinase signal-integrating kinase 2 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP kinase signal-integrating kinase 2 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP/microtubule affinity-regulating kinase 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
MAP/microtubule affinity-regulating kinase 2 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP/microtubule affinity-regulating kinase 2 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MAP/microtubule affinity-regulating kinase 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Maternal embryonic leucine zipper kinase |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Maternal embryonic leucine zipper kinase |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
MDA-MB-231 |
Activity |
30.0 |
% |
10.1016/j.bmc.2014.12.004 |
| Homo sapiens |
Misshapen-like kinase 1 |
Residual Activity |
27.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Misshapen-like kinase 1 |
Residual Activity |
72.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 11 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 5 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 5 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 5 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 7 |
Residual Activity |
71.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 7 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 9 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase 9 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 2 |
Residual Activity |
27.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 2 |
Residual Activity |
43.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Mitogen-activated protein kinase kinase kinase kinase 5 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Mixed lineage kinase 7 |
IC50 |
1400.0 |
nM |
10.1021/jm058209g |
| Homo sapiens |
Muscle, skeletal receptor tyrosine protein kinase |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Muscle, skeletal receptor tyrosine protein kinase |
Residual Activity |
79.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Muscle, skeletal receptor tyrosine protein kinase |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Myosin light chain kinase, smooth muscle |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Myosin light chain kinase, smooth muscle |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Myosin light chain kinase, smooth muscle |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Myotonin-protein kinase |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Myotonin-protein kinase |
Residual Activity |
127.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Myotonin-protein kinase |
Residual Activity |
140.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Nerve growth factor receptor Trk-A |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Nerve growth factor receptor Trk-A |
Residual Activity |
72.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Nerve growth factor receptor Trk-A |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Neurotrophic tyrosine kinase receptor type 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Neurotrophic tyrosine kinase receptor type 2 |
Residual Activity |
117.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Neurotrophic tyrosine kinase receptor type 2 |
Residual Activity |
127.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Non-receptor tyrosine-protein kinase TNK1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
NT-3 growth factor receptor |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
NUAK family SNF1-like kinase 1 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
NUAK family SNF1-like kinase 1 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
PAS domain-containing serine/threonine-protein kinase |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
PAS domain-containing serine/threonine-protein kinase |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Phosphorylase kinase gamma subunit 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Phosphorylase kinase gamma subunit 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Phosphorylase kinase gamma subunit 2 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Phosphorylase kinase gamma subunit 2 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Platelet-derived growth factor receptor alpha |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Platelet-derived growth factor receptor alpha |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Platelet-derived growth factor receptor alpha |
Residual Activity |
114.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Platelet-derived growth factor receptor beta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Platelet-derived growth factor receptor beta |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Platelet-derived growth factor receptor beta |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C alpha |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Protein kinase C alpha |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C alpha |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C beta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Protein kinase C beta |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C beta |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C beta |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C beta |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C delta |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C delta |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C epsilon |
Residual Activity |
74.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C epsilon |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C eta |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C eta |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C gamma |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C gamma |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C iota |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C iota |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C mu |
Residual Activity |
22.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C mu |
Residual Activity |
65.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C theta |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C theta |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C zeta |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase C zeta |
Residual Activity |
123.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase N2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Protein kinase N2 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein kinase N2 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein tyrosine kinase 2 beta |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Protein tyrosine kinase 2 beta |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Protein tyrosine kinase 2 beta |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase MER |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase MER |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase MER |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase ROS |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase ROS |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Proto-oncogene tyrosine-protein kinase ROS |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Pyruvate dehydrogenase kinase isoform 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Receptor protein-tyrosine kinase erbB-2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Receptor protein-tyrosine kinase erbB-4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Receptor protein-tyrosine kinase erbB-4 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Rho-associated protein kinase 1 |
Residual Activity |
117.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Rho-associated protein kinase 1 |
Residual Activity |
127.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Rho-associated protein kinase 2 |
Residual Activity |
76.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Rho-associated protein kinase 2 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase 1 |
Residual Activity |
58.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase 1 |
Residual Activity |
72.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 1 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 1 |
Residual Activity |
117.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 2 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 2 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 3 |
Residual Activity |
60.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 3 |
Residual Activity |
62.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 4 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 4 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 5 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 5 |
Residual Activity |
115.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 5 |
Residual Activity |
125.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 6 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Ribosomal protein S6 kinase alpha 6 |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Runt-related transcription factor 1/Core-binding factor subunit beta |
Potency |
39810.7 |
nM |
None |
| Homo sapiens |
Serine/threonine-protein kinase 10 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 10 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 10 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 11 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 11 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 11 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 16 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 17A |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 17A |
Residual Activity |
65.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 17A |
Residual Activity |
119.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 17B |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 24 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 24 |
Residual Activity |
65.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 24 |
Residual Activity |
66.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 25 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 32B |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 32C |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 33 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase 33 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 33 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase 38-like |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase AKT |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase AKT |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase AKT2 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT2 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase AKT3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase AKT3 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-A |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-A |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-A |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-B |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-B |
Residual Activity |
51.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-B |
Residual Activity |
75.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-C |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-C |
Residual Activity |
66.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Aurora-C |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase B-raf |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase Chk1 |
Residual Activity |
89.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Chk1 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Chk2 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Chk2 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase D2 |
Residual Activity |
66.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase D2 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase DCLK2 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase DCLK2 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase EEF2K |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase EEF2K |
Residual Activity |
121.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase GAK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase haspin |
Residual Activity |
49.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase haspin |
Residual Activity |
71.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MARK1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase MARK1 |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MARK1 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK-A |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK-A |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK-A |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK beta |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MRCK beta |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase MST1 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST1 |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase MST2 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase MST4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase mTOR |
Residual Activity |
121.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Nek11 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Nek11 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase NEK2 |
Residual Activity |
82.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK2 |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Nek3 |
Residual Activity |
111.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Nek3 |
Residual Activity |
118.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK6 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase NEK6 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK6 |
Residual Activity |
116.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK7 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase NEK7 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK7 |
Residual Activity |
118.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase NEK9 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine protein kinase NLK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine protein kinase NLK |
Residual Activity |
27.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine protein kinase NLK |
Residual Activity |
72.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 2 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 2 |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 3 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 3 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 4 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK 4 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK6 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PAK6 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK6 |
Residual Activity |
116.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK7 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PAK7 |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PAK7 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PCTAIRE-1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PIM1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PIM1 |
Residual Activity |
85.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM1 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PIM2 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM2 |
Residual Activity |
120.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM3 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PIM3 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PLK1 |
Residual Activity |
72.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK1 |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK2 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK2 |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PLK3 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK3 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PLK4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PRKX |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase PRKX |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase PRKX |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase RAF |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase RAF |
Residual Activity |
51.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase RAF |
Residual Activity |
81.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase receptor R3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase RIPK2 |
Activity |
26.6 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase RIPK2 |
Residual Activity |
16.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase RIPK2 |
Residual Activity |
29.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk1 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk1 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk2 |
Residual Activity |
69.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk2 |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk3 |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase Sgk3 |
Residual Activity |
117.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SIK1 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SIK1 |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SIK2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK1 |
Residual Activity |
106.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK1 |
Residual Activity |
108.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK2 |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK2 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK3 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase SRPK3 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO1 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO1 |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO2 |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO2 |
Residual Activity |
103.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO3 |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TAO3 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TBK1 |
Residual Activity |
66.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase TBK1 |
Residual Activity |
71.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase tousled-like 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase tousled-like 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase tousled-like 2 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase tousled-like 2 |
Residual Activity |
99.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase ULK2 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase ULK2 |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase ULK3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Serine/threonine-protein kinase ULK3 |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase ULK3 |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase VRK2 |
Residual Activity |
67.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase VRK2 |
Residual Activity |
95.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase WNK2 |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase WNK2 |
Residual Activity |
105.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase WNK3 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Serine/threonine-protein kinase WNK3 |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Stem cell growth factor receptor |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Stem cell growth factor receptor |
Residual Activity |
101.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Stem cell growth factor receptor |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Suppressor of fused homolog |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Testis-specific serine/threonine-protein kinase 1 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Testis-specific serine/threonine-protein kinase 1 |
Residual Activity |
92.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Testis-specific serine/threonine-protein kinase 2 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Testis-specific serine/threonine-protein kinase 2 |
Residual Activity |
96.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
TGF-beta receptor type I |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
TGF-beta receptor type I |
IC50 |
27.0 |
nM |
10.1021/jm8011036 |
| Homo sapiens |
TGF-beta receptor type I |
IC50 |
40.0 |
nM |
10.1021/jm058209g |
| Homo sapiens |
TGF-beta receptor type I |
IC50 |
40.0 |
nM |
10.1021/jm301144g |
| Homo sapiens |
TGF-beta receptor type I |
IC50 |
47.0 |
nM |
10.1021/jm0205705 |
| Homo sapiens |
TGF-beta receptor type I |
IC50 |
51.0 |
nM |
10.1016/j.ejmech.2009.07.008 |
| Homo sapiens |
TGF-beta receptor type I |
IC50 |
51.0 |
nM |
10.1021/jm0205705 |
| Homo sapiens |
TGF-beta receptor type I |
IC50 |
59.0 |
nM |
10.1021/jm058209g |
| Homo sapiens |
TGF-beta receptor type I |
IC50 |
59.0 |
nM |
10.1021/jm701199p |
| Homo sapiens |
TGF-beta receptor type I |
IC50 |
89.0 |
nM |
10.1021/jm0205705 |
| Homo sapiens |
TGF-beta receptor type I |
IC50 |
27000.0 |
nM |
10.1016/j.bmcl.2003.09.028 |
| Homo sapiens |
TGF-beta receptor type I |
Kd |
5.0 |
nM |
10.1016/j.bmcl.2003.09.028 |
| Homo sapiens |
TGF-beta receptor type I |
Residual Activity |
0.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
TGF-beta receptor type I |
Residual Activity |
6.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
TGF-beta receptor type II |
IC50 |
400.0 |
nM |
10.1021/jm058209g |
| Homo sapiens |
TRAF2- and NCK-interacting kinase |
Activity |
1.7 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine- and threonine-specific cdc2-inhibitory kinase |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine kinase non-receptor protein 2 |
Residual Activity |
50.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine kinase non-receptor protein 2 |
Residual Activity |
77.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ABL |
Activity |
21.6 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase ABL |
Residual Activity |
14.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ABL |
Residual Activity |
69.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ABL2 |
Activity |
1.4 |
% |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase ABL2 |
Kd |
1870.0 |
nM |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase ABL2 |
Residual Activity |
18.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ABL2 |
Residual Activity |
64.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BLK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase BLK |
Residual Activity |
59.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BLK |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BMX |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase BMX |
Residual Activity |
66.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BMX |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BRK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase BRK |
Residual Activity |
37.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BRK |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BTK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase BTK |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase BTK |
Residual Activity |
102.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase CSK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase CSK |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase CSK |
Residual Activity |
121.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FER |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase FER |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FER |
Residual Activity |
116.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FES |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase FES |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FES |
Residual Activity |
107.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FGR |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase FGR |
Residual Activity |
51.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FGR |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FRK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase FRK |
Residual Activity |
25.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FRK |
Residual Activity |
84.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FYN |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase FYN |
Residual Activity |
22.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase FYN |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Residual Activity |
69.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Residual Activity |
72.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase HCK |
Residual Activity |
100.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ITK/TSK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase ITK/TSK |
Residual Activity |
97.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ITK/TSK |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase JAK1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase JAK2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase JAK2 |
Residual Activity |
94.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase JAK2 |
Residual Activity |
109.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase JAK3 |
Residual Activity |
110.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase JAK3 |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Residual Activity |
66.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Residual Activity |
71.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase LCK |
Residual Activity |
123.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase Lyn |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase Lyn |
Residual Activity |
24.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase Lyn |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor FLT3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase receptor FLT3 |
Residual Activity |
23.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor FLT3 |
Residual Activity |
48.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor RET |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase receptor RET |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor RET |
Residual Activity |
104.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor TYRO3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase receptor TYRO3 |
Residual Activity |
75.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor TYRO3 |
Residual Activity |
93.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor UFO |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase receptor UFO |
Residual Activity |
65.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase receptor UFO |
Residual Activity |
80.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase SRC |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase SRC |
Residual Activity |
86.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase SRC |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase SYK |
Residual Activity |
87.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase SYK |
Residual Activity |
120.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TEC |
Residual Activity |
88.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TEC |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TIE-2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase TIE-2 |
Residual Activity |
90.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TIE-2 |
Residual Activity |
91.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TXK |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase TXK |
Residual Activity |
64.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TXK |
Residual Activity |
113.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase TYK2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase YES |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase YES |
Residual Activity |
53.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase YES |
Residual Activity |
98.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ZAP-70 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Tyrosine-protein kinase ZAP-70 |
Residual Activity |
112.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Tyrosine-protein kinase ZAP-70 |
Residual Activity |
119.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Uncharacterized aarF domain-containing protein kinase 4 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Vascular endothelial growth factor receptor 1 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Vascular endothelial growth factor receptor 1 |
Residual Activity |
7.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 1 |
Residual Activity |
36.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 2 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Vascular endothelial growth factor receptor 2 |
Residual Activity |
23.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 2 |
Residual Activity |
57.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 3 |
Activity |
nan |
None |
10.1021/jm8011036 |
| Homo sapiens |
Vascular endothelial growth factor receptor 3 |
Residual Activity |
10.0 |
% |
10.1042/bj20121418 |
| Homo sapiens |
Vascular endothelial growth factor receptor 3 |
Residual Activity |
37.0 |
% |
10.1042/bj20121418 |
| Mus musculus |
NIH3T3 |
IC50 |
81.0 |
nM |
10.1021/jm701199p |
| Mus musculus |
Nuclear receptor ROR-gamma |
Potency |
1995.3 |
nM |
None |
| Mus musculus |
Nuclear receptor ROR-gamma |
Potency |
3162.3 |
nM |
None |
| Schistosoma mansoni |
Schistosoma mansoni |
In vitro activity |
nan |
None |
10.6019/CHEMBL5096127 |
| Severe acute respiratory syndrome coronavirus 2 |
Replicase polyprotein 1ab |
Inhibition |
10.91 |
% |
10.6019/CHEMBL4495564 |
| Severe acute respiratory syndrome coronavirus 2 |
Replicase polyprotein 1ab |
Inhibition |
21.76 |
% |
10.6019/CHEMBL4495564 |
| Severe acute respiratory syndrome coronavirus 2 |
SARS-CoV-2 |
Inhibition |
0.16 |
% |
10.6019/CHEMBL4495565 |
| Severe acute respiratory syndrome coronavirus 2 |
SARS-CoV-2 |
Inhibition |
0.32 |
% |
10.6019/CHEMBL4495565 |
| Severe acute respiratory syndrome coronavirus 2 |
SARS-CoV-2 |
Inhibition |
34.6 |
% |
10.21203/rs.3.rs-23951/v1 |
| None |
ADMET |
Stability |
98.0 |
% |
10.1021/jm701199p |
| None |
NON-PROTEIN TARGET |
IC50 |
40.0 |
nM |
10.1021/jm701199p |
| None |
No relevant target |
LogD7.4 |
2.57 |
None |
10.6019/CHEMBL3301361 |
| None |
No relevant target |
Solubility |
26300.0 |
nM |
10.6019/CHEMBL3301361 |
| None |
Unchecked |
Activity |
2.4 |
% |
10.1021/jm8011036 |
| None |
Unchecked |
Activity |
nan |
None |
10.1021/jm8011036 |
| None |
Unchecked |
IC50 |
81.0 |
nM |
10.1021/jm058209g |
| None |
Unchecked |
MOTILITY REDUCTION/CYTOTOXICITY |
0.0 |
% |
10.6019/CHEMBL3988181 |
