Mimosamycin
AlkaPlorer ID: AK153765
Synonym: None
IUPAC Name: 7-methoxy-1,2,6-trimethylisoquinoline-3,5,8-trione
Structure
SMILES: COC1=C(C)C(=O)C2=CC(=O)N(C)C(C)=C2C1=O
InChI: InChI=1S/C13H13NO4/c1-6-11(16)8-5-9(15)14(3)7(2)10(8)12(17)13(6)18-4/h5H,1-4H3
InChIKey: ZYWCMKYDEGVQCK-UHFFFAOYSA-N
Reference
A New Isoquinoline Alkaloid from the Marine Sponge <i>Haliclona</i> Species
PubChem CID: 44566893
LOTUS: LTS0134569
NPASS: NPC475614
COCONUT: CNP0409728
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Haliclona sp. | Haliclona | Chalinidae | Haplosclerida | Demospongiae | Porifera | Metazoa | Eukaryota |
Properties Information
Molecule Weight: 247.25
TPSA？: 65.37
MolLogP？: 0.99312
Number of H-Donors: 0
Number of H-Acceptors: 5
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bacillus subtilis | Bacillus subtilis | IZ | 22.0 | mm | 10.1021/np960258w |
| Cladosporium cucumerinum | Cladosporium cucumerinum | IZ | 15.0 | mm | 10.1021/np960258w |
| Cladosporium cucumerinum | Cladosporium cucumerinum | IZ | 15.0 | mm | 10.1021/np970276t |
| Cladosporium cucumerinum | Cladosporium cucumerinum | IZ | 18.0 | mm | 10.1021/np960258w |
| Cladosporium cucumerinum | Cladosporium cucumerinum | IZ | 18.0 | mm | 10.1021/np970276t |
| Escherichia coli | Escherichia coli | Activity | nan | None | 10.1021/np960258w |
| Homo sapiens | Endothelial PAS domain-containing protein 1 | EC50 | 100000.0 | nM | 10.1021/np300211x |
| Homo sapiens | OVCAR-3 | IC50 | 10.0 | ug.mL-1 | 10.1021/np0102004 |
| Spodoptera littoralis | Spodoptera littoralis | Activity | 15.0 | % | 10.1021/np960258w |
| Staphylococcus aureus | Staphylococcus aureus | IZ | 17.0 | mm | 10.1021/np960258w |
| None | NON-PROTEIN TARGET | IC50 | 10.0 | ug.mL-1 | 10.1021/np0102004 |