Pumiliotoxin B
AlkaPlorer ID: AK156922
Synonym: ''
IUPAC Name: (E,2R,3R,7R,8Z)-8-[(8S,8aS)-8-hydroxy-8-methyl-1,2,3,5,7,8a-hexahydroindolizin-6-ylidene]-4,7-dimethyloct-4-ene-2,3-diol
Structure
SMILES: C/C(=C\C[C@@H](C)/C=C1\CN2CCC[C@H]2[C@@](C)(O)C1)[C@@H](O)[C@@H](C)O
InChI: InChI=1S/C19H33NO3/c1-13(7-8-14(2)18(22)15(3)21)10-16-11-19(4,23)17-6-5-9-20(17)12-16/h8,10,13,15,17-18,21-23H,5-7,9,11-12H2,1-4H3/b14-8+,16-10-/t13-,15-,17+,18-,19+/m1/s1
InChIKey: WDSCDQQQRGGVPJ-AJTVHMNJSA-N
Reference
Toxicity of Panamanian Poison Frogs ( <i>Dendrobates</i> ): Some Biological and Chemical Aspects
PubChem CID: 11393144
LOTUS: LTS0195020
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Oophaga pumilio | Oophaga | Dendrobatidae | Anura | Amphibia | Chordata | Metazoa | Eukaryota |
Properties Information
Molecule Weight: 323.477
TPSA？: 63.93000000000001
MolLogP？: 2.2461000000000007
Number of H-Donors: 3
Number of H-Acceptors: 4
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Cavia porcellus | Cavia porcellus | Activity | 3.05 | nM (mg of protein)-1 | 10.1021/jm00397a036 |
| Cavia porcellus | Cavia porcellus | Activity | 280.0 | % | 10.1021/jm00397a036 |
| Cavia porcellus | Cavia porcellus | Activity | nan | None | 10.1021/jm00397a036 |
| Mus musculus | Mus musculus | Activity | 150.0 | % | 10.1021/jm00397a036 |