Ancistrotanzanine C
AlkaPlorer ID: AK169841
Synonym: None
IUPAC Name: (1R,3S)-7-(1-hydroxy-8-methoxy-3-methylnaphthalen-2-yl)-8-methoxy-1,2,3-trimethyl-3,4-dihydro-1H-isoquinolin-6-ol
Structure
SMILES: COC1=C2C(=CC(O)=C1C1=C(C)C=C3C=CC=C(OC)C3=C1O)C[C@H](C)N(C)[C@@H]2C
InChI: InChI=1S/C25H29NO4/c1-13-10-16-8-7-9-19(29-5)22(16)24(28)20(13)23-18(27)12-17-11-14(2)26(4)15(3)21(17)25(23)30-6/h7-10,12,14-15,27-28H,11H2,1-6H3/t14-,15+/m0/s1
InChIKey: UKOYLRKCEGOLOJ-LSDHHAIUSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Ancistrocladus heyneanus | Ancistrocladus | Ancistrocladaceae | Caryophyllales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
| Ancistrocladus tanzaniensis | Ancistrocladus | Ancistrocladaceae | Caryophyllales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 407.51000000000016
TPSA？: 62.16
MolLogP？: 5.181020000000004
Number of H-Donors: 2
Number of H-Acceptors: 5
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Leishmania donovani | Leishmania donovani | IC50 | nan | None | 10.1021/np0340549 |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 0.1 | ug.mL-1 | 10.1021/np0340549 |
| Plasmodium falciparum | Plasmodium falciparum | IC50 | 4.2 | ug.mL-1 | 10.1021/np0340549 |
| Rattus norvegicus | L6 | Activity | nan | None | 10.1021/np0340549 |
| Rattus norvegicus | L6 | MIC | 40.7 | ug.mL-1 | 10.1021/np0340549 |
| Trypanosoma brucei rhodesiense | Trypanosoma brucei rhodesiense | IC50 | 1.3 | ug.mL-1 | 10.1021/np0340549 |
| Trypanosoma cruzi | Trypanosoma cruzi | IC50 | 14.0 | ug.mL-1 | 10.1021/np0340549 |