Luotonin F
AlkaPlorer ID: AK174606
Synonym: ''
IUPAC Name: 2-(quinoline-3-carbonyl)-3H-quinazolin-4-one
Structure
SMILES: O=C(C1=CN=C2C=CC=CC2=C1)C1=NC2=CC=CC=C2C(O)=N1
InChI: InChI=1S/C18H11N3O2/c22-16(12-9-11-5-1-3-7-14(11)19-10-12)17-20-15-8-4-2-6-13(15)18(23)21-17/h1-10H,(H,20,21,23)
InChIKey: HSEIGGKZBVNIDH-UHFFFAOYSA-N
Reference
Two New Quinazoline-Quinoline Alkaloids from Peganum nigellastrum
PubChem CID: 135457794
CAS: 244616-85-1
LOTUS: LTS0266266
COCONUT: CNP0124299
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Peganum nigellastrum | Peganum | Nitrariaceae | Sapindales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 301.30500000000006
TPSA？: 75.97
MolLogP？: 3.1146000000000016
Number of H-Donors: 1
Number of H-Acceptors: 5
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | DNA topoisomerase II | IC50 | 25000.0 | nM | 10.1016/j.bmcl.2003.12.048 |
| Mus musculus | P388 | IC50 | 20.0 | ug.mL-1 | 10.1016/j.bmcl.2003.12.048 |