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2-Amino-4-methylpyridine

AlkaPlorer ID: AK184276

Synonym: 2-Amino-γ-picoline, 4-Methyl-2-pyridinamine, W 45

IUPAC Name: 4-methylpyridin-2-amine

Structure

SMILES: CC1=CC=NC(N)=C1

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InChI: InChI=1S/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8)

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InChIKey: ORLGLBZRQYOWNA-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
None Acacia Fabaceae Fabales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 108.144

TPSA？: 38.91

MolLogP？: 0.97222

Number of H-Donors: 1

Number of H-Acceptors: 2

RingCount: 1

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Cytochrome P450 1A2 AC50 nan None None
Homo sapiens Cytochrome P450 2C19 AC50 nan None None
Homo sapiens Cytochrome P450 2C9 AC50 nan None None
Homo sapiens Cytochrome P450 2D6 AC50 nan None None
Homo sapiens Cytochrome P450 3A4 AC50 nan None None
Homo sapiens Lysine-specific demethylase 4D-like Potency 35481.3 nM None
Homo sapiens Menin/Histone-lysine N-methyltransferase MLL Potency 31622.8 nM None
Homo sapiens Nitric-oxide synthase, brain Activity 21.0 % 10.1016/j.ejmech.2008.12.007
Homo sapiens Nitric-oxide synthase, brain IC50 40.0 nM 10.1021/jm030519g
Homo sapiens Nitric-oxide synthase, brain IC50 75.0 nM 10.1016/s0960-894x(00)00389-9
Homo sapiens Nitric-oxide synthase, brain IC50 110.0 nM 10.1021/jm031035n
Homo sapiens Nitric-oxide synthase, brain IC50 160.0 nM 10.1038/nchembio.115
Homo sapiens Nitric-oxide synthase, endothelial Activity 50.0 % 10.1016/j.ejmech.2008.12.007
Homo sapiens Nitric-oxide synthase, endothelial IC50 72.0 nM 10.1016/s0960-894x(00)00389-9
Homo sapiens Nitric-oxide synthase, endothelial IC50 100.0 nM 10.1021/jm030519g
Homo sapiens Nitric-oxide synthase, endothelial IC50 300.0 nM 10.1021/jm031035n
Homo sapiens Nitric-oxide synthase, endothelial IC50 320.0 nM 10.1038/nchembio.115
Homo sapiens Nitric oxide synthase, inducible Activity 29.0 % 10.1016/j.ejmech.2008.12.007
Homo sapiens Nitric oxide synthase, inducible IC50 10.0 nM 10.1021/jm030519g
Homo sapiens Nitric oxide synthase, inducible IC50 120.0 nM 10.1021/jm031035n
Homo sapiens Nitric oxide synthase, inducible IC50 120.0 nM 10.1038/nchembio.115
Homo sapiens Nitric oxide synthase, inducible IC50 170.0 nM 10.1016/s0960-894x(00)00389-9
Homo sapiens Nitric oxide sythases; iNOS & nNOS Ratio IC50 2.7 None 10.1038/nchembio.115
Homo sapiens Nitric oxide sythases; iNOS & nNOS Selectivity 0.4 None 10.1016/s0960-894x(00)00389-9
Mus musculus Mus musculus ED50 25.0 mg.kg-1 10.1016/s0960-894x(00)00389-9
Rattus norvegicus Nitric-oxide synthase, brain IC50 40.0 nM 10.1021/jm030519g
Rattus norvegicus Rattus norvegicus HD40 0.11 mg kg-1 10.1016/s0960-894x(00)00389-9
Severe acute respiratory syndrome coronavirus 2 Replicase polyprotein 1ab Inhibition 2.8 % 10.6019/CHEMBL4495564
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 19952.62 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 IC50 20000.0 nM 10.6019/CHEMBL4651402
Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Inhibition -0.11 % 10.6019/CHEMBL4495565
None Unchecked Activity nan None 10.1038/nchembio.115
None Unchecked Ratio IC50 2.7 None 10.1038/nchembio.115

Metabolism Information