N2,N4-bis(2-methylphenyl)quinazoline-2,4-diamine
AlkaPlorer ID: AK188168
Synonym: None
IUPAC Name: 2-N,4-N-bis(2-methylphenyl)quinazoline-2,4-diamine
Structure
SMILES: CC1=CC=CC=C1NC1=NC(NC2=CC=CC=C2C)=C2C=CC=CC2=N1
InChI: InChI=1S/C22H20N4/c1-15-9-3-6-12-18(15)23-21-17-11-5-8-14-20(17)25-22(26-21)24-19-13-7-4-10-16(19)2/h3-14H,1-2H3,(H2,23,24,25,26)
InChIKey: JXZCGLRIDSIQLD-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 340.43000000000006
TPSA？: 49.84
MolLogP？: 5.733840000000003
Number of H-Donors: 2
Number of H-Acceptors: 4
RingCount: 4
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Serine/threonine-protein kinase EEF2K | Inhibition | nan | % | 10.1016/j.ejmech.2017.12.046 |
| Homo sapiens | Serine/threonine-protein kinase PLK1 | Inhibition | nan | % | 10.1016/j.ejmech.2017.12.046 |
| Sus scrofa | Potassium-transporting ATPase | IC50 | 600.0 | nM | 10.1021/jm00014a027 |