2,3-Dihydro-1H-indol-5-ol
AlkaPlorer ID: AK230985
Synonym: 2,3-Dihydro-5-hydroxy-1H-indole, 5-Hydroxyindoline
IUPAC Name: 2,3-dihydro-1H-indol-5-ol
Structure
SMILES: OC1=CC=C2NCCC2=C1
InChI: InChI=1S/C8H9NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-2,5,9-10H,3-4H2
InChIKey: MPCXQPXCYDDJSR-UHFFFAOYSA-N
Reference
D4 dopamine receptor-selective compounds from the Chinese plant Phoebe chekiangensis
PubChem CID: 10034684
CAS: 172078-33-0
LOTUS: LTS0197137
SuperNatural Ⅲ: SN0231587
COCONUT: CNP0290349
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|---|---|---|---|---|---|---|
| Phoebe chekiangensis | Phoebe | Lauraceae | Laurales | Magnoliopsida | Streptophyta | Viridiplantae | Eukaryota |
Properties Information
Molecule Weight: 135.16600000000005
TPSA？: 32.26
MolLogP？: 1.3602
Number of H-Donors: 2
Number of H-Acceptors: 2
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Homo sapiens | Dopamine D2 receptor | IC50 | 1030.0 | nM | 10.1016/S0960-894X(97)00194-7 |
| Homo sapiens | Dopamine D2 receptor | Ki | 9400.0 | nM | 10.1016/S0960-894X(97)00194-7 |
| Homo sapiens | Dopamine D4 receptor | IC50 | 39200.0 | nM | 10.1016/S0960-894X(97)00194-7 |
| Homo sapiens | Dopamine D4 receptor | Ki | 500.0 | nM | 10.1016/S0960-894X(97)00194-7 |
| Homo sapiens | Dopamine receptors; D2 & D4 | Ratio | 19.0 | None | 10.1016/S0960-894X(97)00194-7 |