Chiniofon
AlkaPlorer ID: AK263826
Synonym: None
IUPAC Name: 8-hydroxy-7-iodoquinoline-5-sulfonic acid
Structure
SMILES: O=S(=O)(O)C1=CC(I)=C(O)C2=NC=CC=C12
InChI: InChI=1S/C9H6INO4S/c10-6-4-7(16(13,14)15)5-2-1-3-11-8(5)9(6)12/h1-4,12H,(H,13,14,15)
InChIKey: ZBJWWKFMHOAPNS-UHFFFAOYSA-N
Source
| Species | Genus | Family | Order | Class | Phylum | Kingdom | Domain |
|---|
Properties Information
Molecule Weight: 351.12100000000004
TPSA？: 87.49000000000001
MolLogP？: 1.7917
Number of H-Donors: 2
Number of H-Acceptors: 4
RingCount: 2
Activities Information
| Organism | Target Name | Standard Type | Standard Value | Standard Units | doi |
|---|---|---|---|---|---|
| Bacillus subtilis | 4'-phosphopantetheinyl transferase ffp | Potency | 2511.9 | nM | None |
| Homo sapiens | Glutaminase kidney isoform, mitochondrial | Potency | 28183.8 | nM | None |
| Homo sapiens | Histone acetyltransferase GCN5 | Potency | 5623.4 | nM | None |
| Homo sapiens | Histone deacetylase 6 | Inhibition | -3.43 | % | 10.6019/CHEMBL4808148 |
| Homo sapiens | Histone deacetylase 6 | Inhibition | -2.71 | % | 10.6019/CHEMBL4808148 |
| Homo sapiens | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 | Potency | 3548.1 | nM | None |
| Homo sapiens | Tyrosyl-DNA phosphodiesterase 1 | Potency | 21136.0 | nM | None |
| Homo sapiens | Vitamin D receptor | Potency | 39810.7 | nM | None |
| Mus musculus | Nuclear receptor ROR-gamma | Potency | 12589.3 | nM | None |
| Photinus pyralis | Luciferin 4-monooxygenase | Potency | 5725.5 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 7568.6 | nM | None |
| Plasmodium falciparum | Plasmodium falciparum | Potency | 15101.4 | nM | None |
| Rattus norvegicus | Catechol O-methyltransferase | IC50 | 7079.46 | nM | 10.1021/jm00226a025 |
| Severe acute respiratory syndrome coronavirus 2 | SARS-CoV-2 | Hit score | 0.2325 | None | 10.1101/2020.04.21.054387 |
| Trypanosoma brucei | 6-phospho-1-fructokinase | Potency | 31622.8 | nM | None |
| Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | Putative uncharacterized protein | Potency | 50118.7 | nM | None |
| None | Unchecked | Ac50 | 28.18 | uM | None |
| None | Unchecked | Ac50 | 31.62 | uM | None |
| None | Unchecked | AC50 | 28183.8 | nM | None |
| None | Unchecked | AC50 | 31622.8 | nM | None |
| None | Unchecked | Potency | 25118.9 | nM | None |