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Isocorypalmine; (S)-form 

AlkaPlorer ID: AK267750

Synonym: None

IUPAC Name: 3,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol

Structure

SMILES: COC1=CC2=C(C=C1O)C1CC3=C(CN1CC2)C(OC)=C(OC)C=C3

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InChI: InChI=1S/C20H23NO4/c1-23-18-5-4-12-8-16-14-10-17(22)19(24-2)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,9-10,16,22H,6-8,11H2,1-3H3

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InChIKey: KDFKJOFJHSVROC-UHFFFAOYSA-N

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Source

Species Genus Family Order Class Phylum Kingdom Domain
Fibraurea recisa Fibraurea Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Tinomiscium petiolare Tinomiscium Menispermaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Glaucium fimbrilligerum Glaucium Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None None Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Dicranostigma Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis yanhusuo Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Pachypodanthium Annonaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis ophiocarpa Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis ternata Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Bocconia frutescens Bocconia Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Imperata cylindrica Imperata Poaceae Poales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
Corydalis turtschaninovii Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Corydalis Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Dicranostigma Papaveraceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Pachypodanthium Annonaceae Magnoliales Magnoliopsida Streptophyta Viridiplantae Eukaryota
None Thalictrum Ranunculaceae Ranunculales Magnoliopsida Streptophyta Viridiplantae Eukaryota

Properties Information

Molecule Weight: 341.40700000000004

TPSA？: 51.16000000000001

MolLogP？: 3.073500000000002

Number of H-Donors: 1

Number of H-Acceptors: 5

RingCount: 4

Activities Information

Organism Target Name Standard Type Standard Value Standard Units doi
Homo sapiens Dopamine D1 receptor Ki 15.0 nM 10.1016/j.bmc.2016.03.037
Homo sapiens Dopamine D2 receptor Ki 102.0 nM 10.1016/j.bmc.2016.03.037
Homo sapiens Dopamine D3 receptor Ki 37.0 nM 10.1016/j.bmc.2016.03.037
Homo sapiens MDA-MB-231 IC50 178000.0 nM 10.1016/j.bmc.2016.03.037
Homo sapiens Sigma opioid receptor Ki 106.0 nM 10.1016/j.bmc.2016.03.037
None Unchecked Ki 1.0 nM 10.1016/j.bmc.2016.03.037
None Unchecked Ratio Ki 2.5 None 10.1016/j.bmc.2016.03.037
None Unchecked Ratio Ki 2.8 None 10.1016/j.bmc.2016.03.037
None Unchecked Ratio Ki 6.8 None 10.1016/j.bmc.2016.03.037
None Unchecked Ratio Ki 106.0 None 10.1016/j.bmc.2016.03.037

Metabolism Information